SIMILAR PATTERNS OF AMINO ACIDS FOR 2BXM_A_IMNA2002

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awb MYO-INOSITOL
MONOPHOSPHATASE

(Homo sapiens) 		PF00459
(Inositol_P) 		5 ILE A 227
LEU A 146
PHE A 140
ARG A 134
GLY A 138
 None
 1.30A 2bxmA-1awbA:
1.2		 2bxmA-1awbA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpy SERINE
CARBOXYPEPTIDASE

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		5 ILE A 159
ARG A 165
PHE A 155
GLY A 116
LYS A 117
 None
 1.29A 2bxmA-1cpyA:
0.0		 2bxmA-1cpyA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A  86
ILE A  63
LEU A  36
PHE A  37
ARG A  48
 None
None
None
UAG  A1498 ( 4.7A)
None
 1.37A 2bxmA-1e8cA:
0.0		 2bxmA-1e8cA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A 280
PHE A 430
TYR A 426
ARG A 267
GLY A 226
 None
 1.09A 2bxmA-1g8xA:
2.9		 2bxmA-1g8xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 LEU A 284
LEU A 433
PHE A 430
TYR A 426
GLY A 226
 None
 1.02A 2bxmA-1g8xA:
2.9		 2bxmA-1g8xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ILE A 291
PHE A 441
TYR A 437
ARG A 278
GLY A 237
 None
 1.18A 2bxmA-1jx2A:
3.5		 2bxmA-1jx2A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 LEU A 295
LEU A 444
PHE A 441
TYR A 437
GLY A 237
 None
 0.94A 2bxmA-1jx2A:
3.5		 2bxmA-1jx2A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)

(Nostoc sp. PCC
7119) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 ARG A  77
LEU A  76
LEU A  52
PHE A  21
GLY A  23
 FAD  A 304 (-4.2A)
None
None
None
None
 1.29A 2bxmA-1qgzA:
undetectable		 2bxmA-1qgzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgv TRNA PSEUDOURIDINE
SYNTHASE B

(Mycobacterium
tuberculosis) 		PF01509
(TruB_N)
PF09142
(TruB_C)
PF16198
(TruB_C_2) 		5 ARG A 291
LEU A 290
ILE A  59
LEU A  63
GLY A  52
 None
 1.26A 2bxmA-1sgvA:
undetectable		 2bxmA-1sgvA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ARG B 472
ILE B 552
LEU B 503
TYR B 545
GLY B 541
 None
 1.11A 2bxmA-1t3qB:
1.1		 2bxmA-1t3qB:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 LEU A 115
ARG A 145
HIS A 146
LEU A 154
PHE A 157
GLY A 189
 None
 0.70A 2bxmA-1tf0A:
38.4		 2bxmA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 LEU A 201
ILE A 231
PHE A 232
ARG A 239
GLY A 236
 None
None
FMT  A 609 ( 4.9A)
None
FMT  A 609 ( 4.7A)
 1.00A 2bxmA-1vp4A:
undetectable		 2bxmA-1vp4A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus) 		PF00063
(Myosin_head) 		5 ILE A 261
PHE A 412
TYR A 408
ARG A 248
GLY A 207
 None
 1.24A 2bxmA-1w8jA:
1.1		 2bxmA-1w8jA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1www PROTEIN (TRKA
RECEPTOR)

(Homo sapiens) 		PF07679
(I-set) 		5 LEU X 348
ILE X 301
LEU X 290
ARG X 347
GLY X 344
 None
 1.28A 2bxmA-1wwwX:
undetectable		 2bxmA-1wwwX:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE

(Escherichia
virus T4) 		PF11440
(AGT) 		5 LEU A1363
ILE A1346
ARG A1359
PHE A1348
TYR A1291
 None
 1.02A 2bxmA-1xv5A:
undetectable		 2bxmA-1xv5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		5 ILE A 195
PHE A 186
ARG A  60
GLY A 207
LYS A 206
 None
None
OXD  A 543 (-4.1A)
None
MN  A 999 ( 2.4A)
 1.29A 2bxmA-1ytmA:
undetectable		 2bxmA-1ytmA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5v TUBULIN GAMMA-1
CHAIN

(Homo sapiens) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 LEU A 192
ILE A 141
HIS A 139
ARG A 194
GLY A 148
 None
 1.03A 2bxmA-1z5vA:
undetectable		 2bxmA-1z5vA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2byk CHRAC-14
CHRAC-16

(Drosophila
melanogaster) 		PF00808
(CBFD_NFYB_HMF) 		5 ARG B  17
ILE B  37
LEU A  79
ARG A  55
GLY A  59
 None
 1.16A 2bxmA-2bykB:
undetectable		 2bxmA-2bykB:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A

(Starkeya
novella) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 ARG A 322
LEU A 316
ILE A  46
PHE A  52
GLY A 127
 None
 1.39A 2bxmA-2ca4A:
undetectable		 2bxmA-2ca4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyj HYPOTHETICAL PROTEIN
PH1505

(Pyrococcus
horikoshii) 		PF04430
(DUF498) 		5 ARG A  32
ILE A  24
LEU A 101
ARG A  33
GLY A  67
 None
 1.21A 2bxmA-2cyjA:
undetectable		 2bxmA-2cyjA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00266
(Aminotran_5) 		5 LEU A 165
ILE A 192
LEU A  66
PHE A  65
GLY A 188
 None
 1.30A 2bxmA-2dr1A:
undetectable		 2bxmA-2dr1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00266
(Aminotran_5) 		5 LEU A 216
ILE A 266
LEU A 270
PHE A  65
GLY A 188
 None
 1.15A 2bxmA-2dr1A:
undetectable		 2bxmA-2dr1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0b NEUREXIN-1-ALPHA

(Bos taurus) 		PF02210
(Laminin_G_2) 		5 LEU A 342
ILE A 344
LEU A 346
TYR A 330
GLY A 349
 None
 1.32A 2bxmA-2h0bA:
undetectable		 2bxmA-2h0bA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in2 PICORNAIN 3C

(Rhinovirus B) 		PF00548
(Peptidase_C3) 		5 LEU A 173
ILE A 156
PHE A  89
ARG A  87
GLY A  88
 None
 1.30A 2bxmA-2in2A:
undetectable		 2bxmA-2in2A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2

(Homo sapiens) 		no annotation 5 LEU B  61
ILE B  67
LEU B 120
ARG B  74
LYS B  73
 None
 1.30A 2bxmA-2jjzB:
2.1		 2bxmA-2jjzB:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kl1 YLBL PROTEIN

(Geobacillus
thermodenitrificans) 		PF13180
(PDZ_2) 		5 ARG A  21
LEU A  70
TYR A  45
ARG A  56
GLY A  33
 None
 1.31A 2bxmA-2kl1A:
undetectable		 2bxmA-2kl1A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lem APOLIPOPROTEIN A-I

(Mus musculus) 		PF01442
(Apolipoprotein) 		5 HIS A 165
LEU A 162
ARG A  26
GLY A  25
LYS A  22
 None
 1.39A 2bxmA-2lemA:
2.3		 2bxmA-2lemA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Aquifex
aeolicus) 		PF00793
(DAHP_synth_1) 		5 LEU A1243
ILE A1026
LEU A1076
PHE A1074
LYS A1021
 None
 1.31A 2bxmA-2nxgA:
undetectable		 2bxmA-2nxgA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9j HYPOTHETICAL PROTEIN
AQ2171

(Aquifex
aeolicus) 		PF08282
(Hydrolase_3) 		5 LEU A 159
ILE A 156
LEU A  48
ARG A   5
GLY A 104
 None
 1.29A 2bxmA-2p9jA:
undetectable		 2bxmA-2p9jA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 ARG A 394
LEU A 398
LEU A 335
GLY A 442
LYS A 441
 None
 1.22A 2bxmA-2pi5A:
2.4		 2bxmA-2pi5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjj MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Novosphingobium
aromaticivorans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ARG A 308
ILE A 117
ARG A 114
PHE A 357
GLY A 360
 None
 1.34A 2bxmA-2qjjA:
undetectable		 2bxmA-2qjjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdl CHYMASE 2

(Mesocricetus
auratus) 		PF00089
(Trypsin) 		5 ILE A 130
ARG A 134
LEU A 181
PHE A 228
ARG A 137
 None
 1.26A 2bxmA-2rdlA:
undetectable		 2bxmA-2rdlA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 ILE A 247
PHE A 432
TYR A 428
ARG A 234
GLY A 193
 None
 1.21A 2bxmA-2v26A:
2.6		 2bxmA-2v26A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE

(Oceanicola
granulosus) 		PF07555
(NAGidase) 		5 ARG A 177
LEU A 178
ILE A 188
ARG A 213
GLY A 209
 None
 1.09A 2bxmA-2xsbA:
2.7		 2bxmA-2xsbA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9e MYOSIN-2

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ILE X 280
PHE X 430
TYR X 426
ARG X 267
GLY X 226
 None
 1.09A 2bxmA-2y9eX:
3.5		 2bxmA-2y9eX:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9e MYOSIN-2

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 LEU X 284
LEU X 433
PHE X 430
TYR X 426
GLY X 226
 None
 0.96A 2bxmA-2y9eX:
3.5		 2bxmA-2y9eX:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Methanococcus
maripaludis) 		PF05889
(SepSecS) 		5 LEU A 280
ILE A 252
LEU A 258
TYR A 290
GLY A 248
 None
 1.19A 2bxmA-2z67A:
undetectable		 2bxmA-2z67A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq7 DIACYLGLYCEROL
KINASE DELTA

(Homo sapiens) 		PF07647
(SAM_2) 		5 LEU A  14
ILE A  58
LEU A  59
GLY A  53
LYS A  51
 None
 1.17A 2bxmA-3bq7A:
undetectable		 2bxmA-3bq7A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		5 LEU A  60
ILE A  66
LEU A 318
PHE A 246
GLY A 245
 None
 1.16A 2bxmA-3bs8A:
undetectable		 2bxmA-3bs8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt6 INFLUENZA B
HEMAGGLUTININ (HA)

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		5 ARG A  50
LEU A 286
PHE A  41
ARG B  65
GLY A 282
 None
 1.26A 2bxmA-3bt6A:
undetectable		 2bxmA-3bt6A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eiq PROGRAMMED CELL
DEATH PROTEIN 4

(Mus musculus) 		PF02847
(MA3) 		5 ILE C 396
LEU C 387
ARG C 403
GLY C 404
LYS C 402
 None
 1.37A 2bxmA-3eiqC:
undetectable		 2bxmA-3eiqC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fds DNA POLYMERASE
SLIDING CLAMP C

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU D  48
ILE D  50
LEU D  52
PHE D  51
TYR D 236
 None
 1.27A 2bxmA-3fdsD:
undetectable		 2bxmA-3fdsD:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyc PUTATIVE GLYCOSIDE
HYDROLASE

(Parabacteroides
distasonis) 		PF12876
(Cellulase-like) 		5 LEU A  69
ILE A 134
ARG A 132
ARG A  75
GLY A  76
 None
 1.34A 2bxmA-3gycA:
undetectable		 2bxmA-3gycA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Methanocaldococcus
jannaschii) 		PF00004
(AAA) 		5 LEU A 298
ILE A 326
ARG A 331
LEU A 322
GLY A 314
 None
 1.09A 2bxmA-3h4mA:
2.4		 2bxmA-3h4mA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		5 ILE A 289
PHE A 438
TYR A 434
ARG A 276
GLY A 235
 None
 1.20A 2bxmA-3i5gA:
3.1		 2bxmA-3i5gA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		5 LEU A 293
LEU A 441
PHE A 438
TYR A 434
GLY A 235
 None
 0.94A 2bxmA-3i5gA:
3.1		 2bxmA-3i5gA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 LEU A  60
ILE A  66
LEU A 318
PHE A 246
GLY A 245
 None
 1.08A 2bxmA-3k28A:
undetectable		 2bxmA-3k28A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE

(Mesorhizobium
loti) 		PF12697
(Abhydrolase_6) 		5 ARG A  16
LEU A  24
HIS A  39
LEU A 107
TYR A  79
 None
None
None
CL  A 279 (-4.4A)
None
 1.28A 2bxmA-3kxpA:
2.6		 2bxmA-3kxpA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Caldanaerobacter
subterraneus) 		PF07700
(HNOB) 		5 LEU A 172
ARG A 163
ARG A 171
GLY A 168
LYS A 166
 None
 1.10A 2bxmA-3lahA:
undetectable		 2bxmA-3lahA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 ARG A 332
LEU A 331
ILE A 317
LEU A  55
TYR A 113
 None
 1.24A 2bxmA-3mduA:
undetectable		 2bxmA-3mduA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp2 NON-STRUCTURAL
PROTEIN 3

(Alphacoronavirus
1) 		PF08715
(Viral_protease) 		5 LEU A  25
ILE A  34
LEU A  84
TYR A  68
GLY A  79
 None
 1.34A 2bxmA-3mp2A:
undetectable		 2bxmA-3mp2A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		5 LEU A 124
ILE A 156
ARG A  26
GLY A 162
LYS A 161
 None
None
SO4  A 236 (-3.5A)
None
None
 1.12A 2bxmA-3ooiA:
undetectable		 2bxmA-3ooiA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		5 LEU A 358
ILE A 360
LEU A 362
TYR A 346
GLY A 365
 None
 1.19A 2bxmA-3poyA:
undetectable		 2bxmA-3poyA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ARG A 784
LEU A 785
ILE A 788
LEU A 790
ARG A 713
 None
03Q  A   1 (-3.1A)
None
None
None
 1.25A 2bxmA-3pp0A:
undetectable		 2bxmA-3pp0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		5 LEU A 342
ILE A 344
LEU A 346
TYR A 330
GLY A 349
 None
 1.19A 2bxmA-3qcwA:
undetectable		 2bxmA-3qcwA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re3 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Francisella
tularensis) 		PF02542
(YgbB) 		5 ARG A 159
ILE A  51
LEU A  47
ARG A   4
GLY A   6
 None
None
None
NA  A 165 (-4.4A)
None
 1.38A 2bxmA-3re3A:
undetectable		 2bxmA-3re3A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 ARG A  96
LEU A 160
ILE A  75
ARG A 103
GLY A 106
 None
None
None
PE4  A 506 (-4.5A)
PE4  A 506 ( 4.1A)
 1.21A 2bxmA-3v4cA:
4.7		 2bxmA-3v4cA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE

(Thermococcus
litoralis) 		PF04587
(ADP_PFK_GK) 		5 ILE A  85
LEU A  47
PHE A 189
ARG A  87
LYS A  90
 None
 1.37A 2bxmA-4b8sA:
undetectable		 2bxmA-4b8sA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		5 ILE A 204
PHE A 355
TYR A 351
ARG A 191
GLY A 150
 None
 1.22A 2bxmA-4byfA:
2.9		 2bxmA-4byfA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		5 LEU A 208
LEU A 358
PHE A 355
TYR A 351
GLY A 150
 None
 1.01A 2bxmA-4byfA:
2.9		 2bxmA-4byfA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce7 UNSATURATED
3S-RHAMNOGLYCURONYL
HYDROLASE

(Nonlabens
ulvanivorans) 		PF07470
(Glyco_hydro_88) 		5 LEU A 191
ILE A 256
HIS A 287
LEU A 291
GLY A 226
 None
 0.92A 2bxmA-4ce7A:
undetectable		 2bxmA-4ce7A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		no annotation 5 ARG A  73
ILE A  30
LEU A  39
PHE A  51
GLY A  49
 None
 1.37A 2bxmA-4czxA:
undetectable		 2bxmA-4czxA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A

(Homo sapiens) 		PF01201
(Ribosomal_S8e) 		5 ILE i 545
LEU i 543
ARG i 605
GLY i 618
LYS i 619
 None
 1.16A 2bxmA-4d61i:
undetectable		 2bxmA-4d61i:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doh INTERLEUKIN-20
INTERLEUKIN-20
RECEPTOR SUBUNIT
ALPHA

(Homo sapiens) 		PF00726
(IL10)
no annotation 		5 LEU A 152
ILE A  64
LEU A  65
TYR R  76
GLY A 163
 None
 1.12A 2bxmA-4dohA:
undetectable		 2bxmA-4dohA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6l AUSA REDUCTASE
DOMAIN PROTEIN

(Staphylococcus
aureus) 		no annotation 5 ARG B2239
ILE B2061
LEU B2049
ARG B2243
GLY B2054
 None
 1.27A 2bxmA-4f6lB:
undetectable		 2bxmA-4f6lB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF12866
(DUF3823) 		5 LEU A 156
ILE A 154
LEU A 173
ARG A 202
GLY A 204
 None
 1.38A 2bxmA-4fxtA:
undetectable		 2bxmA-4fxtA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 5 LEU A 167
HIS A 608
LEU A 561
TYR A 547
GLY A 553
 None
 1.00A 2bxmA-4jzaA:
3.3		 2bxmA-4jzaA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k49 ESTERASE YDII

(Escherichia
coli) 		no annotation 5 ARG C  94
LEU C  53
ARG C  91
GLY C 123
LYS C 122
 None
None
HFQ  C 201 (-3.8A)
None
None
 1.25A 2bxmA-4k49C:
undetectable		 2bxmA-4k49C:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		5 ARG A  32
LEU A  31
LEU A 332
ARG A 324
GLY A 325
 None
 1.36A 2bxmA-4k5rA:
undetectable		 2bxmA-4k5rA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ARG A 106
LEU A 105
ILE A 334
HIS A 331
GLY A 111
 None
 0.86A 2bxmA-4lixA:
2.9		 2bxmA-4lixA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN

(Ketogulonicigenium
vulgare) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ARG A 290
LEU A 100
ILE A 156
PHE A 202
GLY A 108
 None
 1.27A 2bxmA-4lswA:
undetectable		 2bxmA-4lswA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		5 ILE A 285
PHE A 436
TYR A 432
ARG A 272
GLY A 231
 None
 1.28A 2bxmA-4p7hA:
undetectable		 2bxmA-4p7hA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII

(Loxosceles
intermedia) 		no annotation 5 LEU A  88
ILE A 130
LEU A 114
ARG A 127
GLY A 126
 None
 1.12A 2bxmA-4rw3A:
undetectable		 2bxmA-4rw3A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryk LMO0325 PROTEIN

(Listeria
monocytogenes) 		PF01381
(HTH_3) 		5 ILE A  54
LEU A  51
TYR A  23
ARG A   9
GLY A   5
 None
 1.19A 2bxmA-4rykA:
2.5		 2bxmA-4rykA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqb NADP-DEPENDENT
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF02826
(2-Hacid_dh_C) 		5 ARG A 155
LEU A 154
ILE A 173
ARG A 157
GLY A 165
 None
 1.32A 2bxmA-4zqbA:
undetectable		 2bxmA-4zqbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		5 LEU A 239
ILE A 254
HIS A 232
ARG A 240
GLY A 252
 None
 1.31A 2bxmA-5a2rA:
4.7		 2bxmA-5a2rA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e72 N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE

(Thermococcus
kodakarensis) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 ILE A 291
PHE A 297
ARG A 313
GLY A 299
LYS A 300
 None
 1.35A 2bxmA-5e72A:
undetectable		 2bxmA-5e72A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9c HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		5 LEU A 173
ILE A 218
PHE A 258
GLY A 215
LYS A 214
 None
 1.30A 2bxmA-5e9cA:
undetectable		 2bxmA-5e9cA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esz 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160

(Haemophilus
influenzae;
Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF02542
(YgbB) 		5 ARG C 315
ILE C 213
LEU C 209
ARG C 114
GLY C 116
 None
 1.33A 2bxmA-5eszC:
undetectable		 2bxmA-5eszC:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Mus musculus) 		PF00149
(Metallophos) 		5 ARG A 277
LEU A 432
PHE A 287
TYR A 288
GLY A 285
 None
 1.09A 2bxmA-5fcaA:
undetectable		 2bxmA-5fcaA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyd MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A  43
ILE A 135
ARG A  41
LEU A 244
PHE A 248
 None
 1.37A 2bxmA-5gydA:
undetectable		 2bxmA-5gydA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbl PROHEAD CORE PROTEIN
PROTEASE

(Escherichia
virus T4) 		PF03420
(Peptidase_S77) 		5 ARG A 115
LEU A  38
ILE A  17
ARG A 113
GLY A  42
 None
 1.22A 2bxmA-5jblA:
undetectable		 2bxmA-5jblA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj2 A-KINASE ANCHOR
PROTEIN 7 ISOFORM
GAMMA

(Homo sapiens) 		PF10469
(AKAP7_NLS) 		5 ILE A  93
LEU A 220
PHE A 252
GLY A 101
LYS A 100
 None
 1.35A 2bxmA-5jj2A:
undetectable		 2bxmA-5jj2A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT

(Escherichia
coli) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 LEU B 676
ILE B 622
LEU B 626
PHE B 623
GLY B 668
 None
 1.30A 2bxmA-5mrwB:
undetectable		 2bxmA-5mrwB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8d FIBER

(Murine
mastadenovirus
B) 		no annotation 5 ILE A 658
LEU A 687
TYR A 635
ARG A 700
GLY A 699
 None
 1.37A 2bxmA-5n8dA:
undetectable		 2bxmA-5n8dA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 5 ARG A 362
ILE A 276
LEU A 244
PHE A 241
GLY A 270
 None
 1.39A 2bxmA-5utiA:
undetectable		 2bxmA-5utiA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 5 LEU A 138
ILE A 187
ARG A 185
PHE A 148
GLY A  88
 None
 1.21A 2bxmA-5vanA:
undetectable		 2bxmA-5vanA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrb TRANSKETOLASE

(Neisseria
gonorrhoeae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ARG A 355
ILE A 362
LEU A 372
TYR A 401
GLY A 428
 None
 0.98A 2bxmA-5vrbA:
undetectable		 2bxmA-5vrbA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi9 -

(-) 		no annotation 5 LEU A 138
ILE A 187
ARG A 185
PHE A 148
GLY A  88
 None
 1.22A 2bxmA-5wi9A:
undetectable		 2bxmA-5wi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x47 3-DEHYDROQUINATE
DEHYDRATASE

(Acinetobacter
baumannii) 		PF01220
(DHquinase_II) 		5 ARG A  88
LEU A  91
ILE A  62
HIS A  63
GLY A  56
 None
 1.24A 2bxmA-5x47A:
undetectable		 2bxmA-5x47A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xl2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 LEU A 104
ILE A 176
LEU A 147
TYR A 255
GLY A  68
 None
 1.35A 2bxmA-5xl2A:
undetectable		 2bxmA-5xl2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xl6 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 LEU A 104
ILE A 176
LEU A 147
TYR A 255
GLY A  68
 None
 1.28A 2bxmA-5xl6A:
undetectable		 2bxmA-5xl6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		5 LEU w 140
ILE w 195
PHE w 167
TYR w 187
ARG w 139
 None
 1.28A 2bxmA-5xtdw:
undetectable		 2bxmA-5xtdw:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 LEU A 115
ILE A 142
ARG A 145
HIS A 146
LEU A 154
 None
 0.53A 2bxmA-5yxeA:
37.9		 2bxmA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 LEU A 115
ILE A 142
ARG A 145
LEU A 154
TYR A 161
 None
 1.34A 2bxmA-5yxeA:
37.9		 2bxmA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 5 ILE A 292
HIS A 226
LEU A 224
ARG A 257
GLY A 255
 None
 1.09A 2bxmA-5z5dA:
undetectable		 2bxmA-5z5dA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1d UNCONVENTIONAL
MYOSIN-IB

(Rattus
norvegicus) 		no annotation 5 LEU P 211
LEU P 364
PHE P 361
TYR P 357
GLY P 153
 None
 0.97A 2bxmA-6c1dP:
undetectable		 2bxmA-6c1dP:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans) 		no annotation 5 LEU A 239
ILE A  52
LEU A  21
ARG A  56
GLY A  54
 None
GOL  A 503 ( 4.4A)
None
None
None
 1.35A 2bxmA-6enoA:
undetectable		 2bxmA-6enoA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg9 -

(-) 		no annotation 5 LEU A 662
ILE A 469
LEU A 456
PHE A 455
GLY A 453
 None
 1.19A 2bxmA-6fg9A:
undetectable		 2bxmA-6fg9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-) 		no annotation 5 ILE A 285
PHE A 436
TYR A 432
ARG A 272
GLY A 231
 None
None
None
FMT  A2004 (-3.8A)
None
 1.20A 2bxmA-6fsaA:
3.1		 2bxmA-6fsaA:
undetectable