SIMILAR PATTERNS OF AMINO ACIDS FOR 2BXG_B_IBPB2002

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea)
PF01070
(FMN_dh)
5 ALA A 246
ALA A 247
LEU A  65
LEU A 228
ALA A 151
None
1.01A 2bxgB-1al8A:
undetectable
2bxgB-1al8A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
6 ALA A 165
ALA A 164
LEU A 103
LEU A 141
ALA A 144
LEU A 199
None
1.43A 2bxgB-1ciyA:
1.0
2bxgB-1ciyA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ctt CYTIDINE DEAMINASE

(Escherichia
coli)
PF00383
(dCMP_cyt_deam_1)
PF08211
(dCMP_cyt_deam_2)
5 ALA A  61
ALA A  88
LEU A 249
ALA A  31
LEU A  57
None
0.95A 2bxgB-1cttA:
undetectable
2bxgB-1cttA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqs PROTEIN
(3-DEHYDROQUINATE
SYNTHASE)


(Aspergillus
nidulans)
PF01761
(DHQ_synthase)
5 LEU A 367
LEU A 301
ALA A 302
LEU A 391
VAL A 390
None
1.05A 2bxgB-1dqsA:
0.0
2bxgB-1dqsA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE


(Moorella
thermoacetica)
PF00809
(Pterin_bind)
6 ALA A 228
ALA A 226
LEU A 223
ALA A 218
SER A 201
VAL A 200
None
1.46A 2bxgB-1f6yA:
undetectable
2bxgB-1f6yA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE


(Escherichia
coli)
PF00155
(Aminotran_1_2)
5 ARG A 382
ALA A 383
ALA A 386
LEU A 345
VAL A 352
None
0.74A 2bxgB-1fc4A:
undetectable
2bxgB-1fc4A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kij DNA GYRASE SUBUNIT B

(Thermus
thermophilus)
PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
5 ALA A 348
ALA A 345
LEU A 340
LEU A 327
ALA A 270
None
1.06A 2bxgB-1kijA:
0.0
2bxgB-1kijA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION


(Bacillus
subtilis)
PF01256
(Carb_kinase)
5 ALA A  46
ALA A  50
LEU A  55
LEU A  58
ALA A  30
None
1.01A 2bxgB-1kyhA:
undetectable
2bxgB-1kyhA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A


(Thermobifida
fusca)
PF00079
(Serpin)
5 LEU A 286
LEU A 279
ALA A 284
LEU A 271
VAL A 276
None
1.05A 2bxgB-1mtpA:
undetectable
2bxgB-1mtpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcj POKEWEED ANTIVIRAL
PROTEIN


(Phytolacca
americana)
PF00161
(RIP)
5 ALA A  27
LEU A  23
LEU A  71
ALA A 178
SER A 212
None
1.06A 2bxgB-1qcjA:
undetectable
2bxgB-1qcjA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B


(Homo sapiens)
PF00233
(PDEase_I)
5 ALA A 855
ALA A 858
LEU A 727
ALA A 819
VAL A 886
None
0.99A 2bxgB-1sojA:
undetectable
2bxgB-1sojA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1


(Mus musculus)
PF03036
(Perilipin)
6 ALA A 265
ALA A 269
LEU A 273
LEU A 405
ALA A 401
LEU A 262
None
1.39A 2bxgB-1sziA:
2.5
2bxgB-1sziA:
17.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
5 ALA A  21
LEU A 139
LEU A 155
ALA A 158
LYS A 159
None
1.02A 2bxgB-1tf0A:
47.3
2bxgB-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
9 ARG A 209
ALA A 210
ALA A 213
LEU A 331
LEU A 347
ALA A 350
SER A 480
LEU A 481
VAL A 482
DKA  A1001 ( 4.6A)
DKA  A1002 (-3.3A)
DKA  A1001 ( 4.0A)
None
DKA  A1002 ( 4.3A)
DKA  A1002 ( 3.8A)
DKA  A1002 (-3.4A)
None
DKA  A1002 (-4.2A)
0.40A 2bxgB-1tf0A:
47.3
2bxgB-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
5 LEU A 347
LYS A 351
SER A 480
LEU A 481
VAL A 482
DKA  A1002 ( 4.3A)
DKA  A1002 (-2.6A)
DKA  A1002 (-3.4A)
None
DKA  A1002 (-4.2A)
0.90A 2bxgB-1tf0A:
47.3
2bxgB-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450


(Sulfurisphaera
tokodaii)
PF00067
(p450)
5 ALA A 323
ALA A 327
LEU A 331
ALA A 222
SER A 309
HEM  A 410 (-3.4A)
None
None
None
None
0.93A 2bxgB-1ue8A:
undetectable
2bxgB-1ue8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE


(Thermus
thermophilus)
PF00294
(PfkB)
5 ALA A   7
LEU A 113
ALA A 117
SER A 139
LEU A 138
None
1.05A 2bxgB-1v19A:
undetectable
2bxgB-1v19A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vz0 CHROMOSOME-PARTITION
ING PROTEIN SPO0J


(Thermus
thermophilus)
PF02195
(ParBc)
5 ALA A 175
ALA A 178
ALA A 164
SER A 119
VAL A 121
None
0.82A 2bxgB-1vz0A:
undetectable
2bxgB-1vz0A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlj DORMANCY SURVIVAL
REGULATOR


(Mycobacterium
tuberculosis)
PF00196
(GerE)
5 ARG A 197
ALA A 201
ALA A 200
LEU A 188
LEU A 158
None
1.04A 2bxgB-1zljA:
undetectable
2bxgB-1zljA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI


(Saccharopolyspora
erythraea)
PF08659
(KR)
6 ALA A1542
LEU A1549
LEU A1544
ALA A1591
LEU A1778
VAL A1777
None
1.40A 2bxgB-2fr1A:
undetectable
2bxgB-2fr1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwr DNA-BINDING RESPONSE
REGULATOR MTRA


(Mycobacterium
tuberculosis)
PF00072
(Response_reg)
PF00486
(Trans_reg_C)
6 ALA A  41
ALA A  44
LEU A  48
LEU A   9
ALA A  33
LEU A  55
None
1.33A 2bxgB-2gwrA:
undetectable
2bxgB-2gwrA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3o TUSP1

(Nephila
antipodiana)
PF12042
(RP1-2)
5 ALA A  82
ALA A  85
LEU A 107
ALA A  45
SER A  14
None
1.03A 2bxgB-2k3oA:
3.2
2bxgB-2k3oA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN


(Haemophilus
influenzae)
PF01547
(SBP_bac_1)
5 ALA A 231
ALA A 230
LEU A 249
SER A 236
LEU A 233
None
1.03A 2bxgB-2o69A:
undetectable
2bxgB-2o69A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oix XANTHOMONAS OUTER
PROTEIN D


(Xanthomonas
euvesicatoria)
PF02902
(Peptidase_C48)
5 ALA A 425
LEU A 451
ALA A 446
SER A 411
LEU A 412
None
1.06A 2bxgB-2oixA:
undetectable
2bxgB-2oixA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa6 ENOLASE

(Methanocaldococcus
jannaschii)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 ALA A 349
LEU A 140
LEU A 380
ALA A 383
VAL A 365
None
0.94A 2bxgB-2pa6A:
2.1
2bxgB-2pa6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 ALA A 353
LEU A 132
LEU A 384
ALA A 387
VAL A 369
None
1.02A 2bxgB-2ptzA:
undetectable
2bxgB-2ptzA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis)
no annotation 5 ALA A 344
ALA A 312
LEU A 277
LEU A 399
ALA A 395
None
1.04A 2bxgB-2q9uA:
undetectable
2bxgB-2q9uA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans)
PF14498
(Glyco_hyd_65N_2)
5 ALA A 482
LEU A 486
LEU A 553
ALA A 556
LYS A 557
None
0.94A 2bxgB-2rdyA:
undetectable
2bxgB-2rdyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans)
PF14520
(HHH_5)
PF14716
(HHH_8)
5 ALA A 457
LEU A 442
ALA A 445
LEU A 472
VAL A 475
None
1.05A 2bxgB-2w9mA:
undetectable
2bxgB-2w9mA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG


(Mycobacterium
tuberculosis)
PF01474
(DAHP_synth_2)
5 ALA A 241
LEU A 107
ALA A 110
LEU A 196
VAL A 197
TRP  A1464 ( 3.9A)
TRP  A1464 ( 4.4A)
TRP  A1464 (-3.6A)
None
None
1.04A 2bxgB-2ypqA:
undetectable
2bxgB-2ypqA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z55 ARCHAERHODOPSIN-2

(Halobacterium
sp. AUS-2)
PF01036
(Bac_rhodopsin)
5 ALA A 212
LEU A 216
LEU A 193
ALA A 189
VAL A 196
None
0.91A 2bxgB-2z55A:
2.5
2bxgB-2z55A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ady DOTD

(Legionella
pneumophila)
PF16816
(DotD)
5 ALA A  99
ALA A 101
LEU A  41
LEU A 128
ALA A  83
None
1.07A 2bxgB-3adyA:
undetectable
2bxgB-3adyA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense)
PF00326
(Peptidase_S9)
6 ALA A 636
ALA A 639
LEU A 658
LEU A 586
ALA A 616
LEU A 533
None
1.01A 2bxgB-3azqA:
undetectable
2bxgB-3azqA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense)
PF00326
(Peptidase_S9)
5 ARG A 635
ALA A 636
ALA A 639
LEU A 586
ALA A 616
None
0.80A 2bxgB-3azqA:
undetectable
2bxgB-3azqA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bed PTS SYSTEM, IIA
COMPONENT


(Enterococcus
faecalis)
PF03610
(EIIA-man)
5 ALA A  97
ALA A 100
LEU A 111
LEU A   5
LEU A  18
None
0.93A 2bxgB-3bedA:
undetectable
2bxgB-3bedA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI


(Pseudomonas
putida)
PF10778
(DehI)
6 ALA A  65
ALA A  68
LEU A  72
LEU A 119
ALA A 228
SER A  56
None
1.43A 2bxgB-3bjxA:
undetectable
2bxgB-3bjxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B


(Homo sapiens)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
5 ALA A1023
ALA A1026
LEU A1042
ALA A1041
VAL A1078
None
0.98A 2bxgB-3eh1A:
undetectable
2bxgB-3eh1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo2 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN


(Homo sapiens)
PF00621
(RhoGEF)
5 LEU A 228
LEU A 260
ALA A 262
LEU A 350
VAL A 349
None
0.98A 2bxgB-3eo2A:
undetectable
2bxgB-3eo2A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eua PUTATIVE
FRUCTOSE-AMINOACID-6
-PHOSPHATE DEGLYCASE


(Bacillus
subtilis)
PF01380
(SIS)
5 ALA A  96
ALA A  93
LEU A 114
LEU A  79
ALA A 105
None
1.01A 2bxgB-3euaA:
undetectable
2bxgB-3euaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkr L-2-KETO-3-DEOXYARAB
ONATE DEHYDRATASE


(Azospirillum
brasilense)
PF00701
(DHDPS)
5 ARG A 309
ALA A 308
LEU A 304
LEU A 277
VAL A 315
None
1.03A 2bxgB-3fkrA:
undetectable
2bxgB-3fkrA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqp HEMOGLOBIN SUBUNIT
ALPHA


(Felis catus)
PF00042
(Globin)
5 ALA A  69
LEU A  76
SER A  84
LEU A 136
VAL A 135
None
None
None
HEM  A 143 (-4.9A)
None
1.05A 2bxgB-3gqpA:
2.0
2bxgB-3gqpA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE


(Colwellia
psychrerythraea)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
6 ALA A  60
ALA A  57
LEU A  54
LEU A 193
ALA A 189
SER A  65
None
1.34A 2bxgB-3ic9A:
3.4
2bxgB-3ic9A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m16 TRANSALDOLASE

(Oleispira
antarctica)
PF00923
(TAL_FSA)
5 ALA A 244
LEU A 266
LEU A  12
ALA A  11
VAL A  18
None
0.99A 2bxgB-3m16A:
undetectable
2bxgB-3m16A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4h PUTATIVE TAUTOMERASE

(Corynebacterium
glutamicum)
PF14552
(Tautomerase_2)
6 ALA A  34
ALA A  32
LEU A  81
ALA A  27
LEU A  38
VAL A  39
PR7  A   1 ( 3.5A)
None
None
None
PR7  A   1 ( 4.7A)
PR7  A   1 ( 3.6A)
1.21A 2bxgB-3n4hA:
undetectable
2bxgB-3n4hA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhz TWO COMPONENT SYSTEM
TRANSCRIPTIONAL
REGULATOR MTRA


(Mycobacterium
tuberculosis)
PF00072
(Response_reg)
6 ALA A  41
ALA A  44
LEU A  48
LEU A   9
ALA A  33
LEU A  55
None
1.28A 2bxgB-3nhzA:
undetectable
2bxgB-3nhzA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyq MALONYL-COA LIGASE

(Streptomyces
coelicolor)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 ALA A 138
LEU A 160
ALA A 159
LEU A 191
VAL A 192
None
0.98A 2bxgB-3nyqA:
undetectable
2bxgB-3nyqA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6c PYRIDOXINE
5'-PHOSPHATE
SYNTHASE


(Campylobacter
jejuni)
PF03740
(PdxJ)
5 ALA A  79
LEU A  80
LEU A 117
ALA A 120
VAL A 124
None
0.97A 2bxgB-3o6cA:
undetectable
2bxgB-3o6cA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3og4 INTERLEUKIN-29

(Homo sapiens)
PF15177
(IL28A)
5 ALA A  34
ALA A  37
LEU A  91
ALA A  90
LEU A  83
None
0.89A 2bxgB-3og4A:
undetectable
2bxgB-3og4A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII


(Streptomyces
venezuelae)
PF08659
(KR)
5 ALA A 244
ALA A 247
LEU A 258
LEU A 289
ALA A 296
None
0.97A 2bxgB-3qp9A:
undetectable
2bxgB-3qp9A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rij SC_2CX5

(Thermus
thermophilus)
PF04073
(tRNA_edit)
5 ALA A  34
ALA A  37
LEU A  27
LEU A 136
SER A  51
None
0.83A 2bxgB-3rijA:
undetectable
2bxgB-3rijA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1t ASPARTOKINASE

(Mycobacterium
tuberculosis)
PF01842
(ACT)
PF13840
(ACT_7)
6 ALA A 118
LEU A 119
LEU A 152
ALA A 148
LEU A 158
VAL A   9
None
1.29A 2bxgB-3s1tA:
undetectable
2bxgB-3s1tA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1t ASPARTOKINASE

(Mycobacterium
tuberculosis)
PF01842
(ACT)
PF13840
(ACT_7)
6 ALA A 155
ALA A 118
LEU A 119
LEU A 152
ALA A 148
VAL A   9
None
1.44A 2bxgB-3s1tA:
undetectable
2bxgB-3s1tA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Haemophilus
influenzae)
PF00275
(EPSP_synthase)
6 ALA A 244
ALA A 245
LEU A 315
LEU A 268
ALA A 271
VAL A 275
None
1.42A 2bxgB-3sweA:
undetectable
2bxgB-3sweA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uog ALCOHOL
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
6 ALA A 186
ALA A 188
LEU A 306
ALA A 302
LEU A 164
VAL A 159
None
1.37A 2bxgB-3uogA:
undetectable
2bxgB-3uogA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7i PUTATIVE POLYKETIDE
SYNTHASE


(Streptomyces
coelicolor)
PF00195
(Chal_sti_synt_N)
5 ALA A 370
LEU A 310
ALA A 359
LEU A 389
VAL A 243
None
0.95A 2bxgB-3v7iA:
undetectable
2bxgB-3v7iA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Aliivibrio
fischeri)
PF00275
(EPSP_synthase)
6 ALA A 243
ALA A 244
LEU A 314
LEU A 267
ALA A 270
VAL A 274
None
1.49A 2bxgB-3vcyA:
undetectable
2bxgB-3vcyA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7


(Saccharomyces
cerevisiae)
PF00899
(ThiF)
PF16420
(ATG7_N)
6 ALA A 460
LEU A 462
LEU A 335
ALA A 515
SER A 340
LEU A 329
None
1.45A 2bxgB-3vh1A:
undetectable
2bxgB-3vh1A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
ALPHA


(Mammuthus
primigenius)
PF00042
(Globin)
6 ALA A  69
LEU A  73
LEU A  76
SER A  84
LEU A 136
VAL A 135
None
1.46A 2bxgB-3vreA:
2.1
2bxgB-3vreA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE


(Pseudomonas
aeruginosa)
PF00348
(polyprenyl_synt)
5 ALA A  68
ALA A  69
ALA A  16
LEU A 124
VAL A 123
None
0.99A 2bxgB-3zouA:
2.4
2bxgB-3zouA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
6 ALA A 165
ALA A 164
LEU A 103
LEU A 141
ALA A 144
LEU A 199
None
1.46A 2bxgB-4arxA:
3.3
2bxgB-4arxA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE


(Methanosarcina
mazei)
PF01208
(URO-D)
5 ALA A 182
ALA A 185
LEU A 118
LEU A  81
ALA A  84
None
0.72A 2bxgB-4ay7A:
undetectable
2bxgB-4ay7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3


(Neurospora
crassa)
no annotation 5 ALA A 406
LEU A 423
LEU A 396
ALA A 395
VAL A 506
None
1.07A 2bxgB-4bwkA:
undetectable
2bxgB-4bwkA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae)
PF00275
(EPSP_synthase)
6 ALA A  45
ALA A  43
LEU A 228
LEU A 201
ALA A 204
LEU A 111
None
1.35A 2bxgB-4fqdA:
undetectable
2bxgB-4fqdA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL


(Arabidopsis
thaliana)
PF16953
(PRORP)
PF17177
(PPR_long)
5 ALA A 227
ALA A 230
LEU A 218
LEU A 252
ALA A 251
None
1.00A 2bxgB-4g25A:
undetectable
2bxgB-4g25A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go5 ASPARTOKINASE

(Mycobacterium
tuberculosis)
PF01842
(ACT)
PF13840
(ACT_7)
6 ALA X 155
ALA X 118
LEU X 119
LEU X 152
ALA X 148
VAL X   9
None
1.44A 2bxgB-4go5X:
undetectable
2bxgB-4go5X:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpp PROBABLE GLUTAMINE
SYNTHETASE


(Pseudomonas
aeruginosa)
PF00120
(Gln-synt_C)
PF16952
(Gln-synt_N_2)
5 ALA A 345
ALA A 348
LEU A 404
LEU A 277
ALA A 276
None
0.79A 2bxgB-4hppA:
undetectable
2bxgB-4hppA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE


(Agrobacterium
fabrum)
PF13561
(adh_short_C2)
5 ALA A 235
LEU A 232
LEU A  31
ALA A  34
VAL A  38
None
0.98A 2bxgB-4imrA:
undetectable
2bxgB-4imrA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN


(Thermococcus
onnurineus)
PF13646
(HEAT_2)
5 ALA A 116
LEU A  77
SER A 140
LEU A 139
VAL A 138
None
1.07A 2bxgB-4l7mA:
2.1
2bxgB-4l7mA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE


(Burkholderia
cenocepacia)
PF01041
(DegT_DnrJ_EryC1)
5 ARG A 171
LEU A 247
LEU A  46
ALA A  45
VAL A  55
None
0.98A 2bxgB-4lc3A:
undetectable
2bxgB-4lc3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuf MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
NUCLEAR RECEPTOR
SUBFAMILY 0 GROUP B
MEMBER 2 CHIMERIC
CONSTRUCT


(Escherichia
coli;
Mus musculus)
PF00104
(Hormone_recep)
PF13416
(SBP_bac_8)
5 LEU A1156
LEU A1103
ALA A1104
LEU A1066
VAL A1065
None
1.03A 2bxgB-4nufA:
2.0
2bxgB-4nufA:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
8 ALA A 210
ALA A 213
LEU A 331
LEU A 347
LYS A 351
SER A 480
LEU A 481
VAL A 482
None
NPS  A 602 (-3.3A)
None
NPS  A 602 ( 4.2A)
None
None
None
None
0.74A 2bxgB-4po0A:
48.9
2bxgB-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
7 ARG A 209
ALA A 210
ALA A 213
LEU A 331
SER A 480
LEU A 481
VAL A 482
NPS  A 602 (-3.6A)
None
NPS  A 602 (-3.3A)
None
None
None
None
0.87A 2bxgB-4po0A:
48.9
2bxgB-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE


(Bradyrhizobium
diazoefficiens)
PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg)
5 ALA A 690
ALA A 693
LEU A 583
LEU A 665
ALA A 612
None
0.89A 2bxgB-4q73A:
undetectable
2bxgB-4q73A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2


(Mycobacterium
tuberculosis)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD)
5 ALA A  76
ALA A  78
LEU A  95
ALA A  98
VAL A  35
None
1.00A 2bxgB-4uaqA:
undetectable
2bxgB-4uaqA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
6 ALA A 165
ALA A 164
LEU A 103
LEU A 141
ALA A 144
LEU A 199
None
1.47A 2bxgB-4w8jA:
3.0
2bxgB-4w8jA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5af3 VAPBC49

(Mycobacterium
tuberculosis)
PF04255
(DUF433)
5 ALA A  74
ALA A  76
LEU A  32
LEU A  25
ALA A  21
None
1.07A 2bxgB-5af3A:
undetectable
2bxgB-5af3A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbm M17 FAMILY
AMINOPEPTIDASE


(Plasmodium
falciparum)
PF00883
(Peptidase_M17)
5 ALA A 313
ALA A 314
LEU A 357
LEU A 407
ALA A 410
None
1.01A 2bxgB-5cbmA:
undetectable
2bxgB-5cbmA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwc DESIGNED HELICAL
REPEAT PROTEIN


(synthetic
construct)
no annotation 5 ALA A  95
ALA A  98
ALA A 145
LEU A 106
VAL A 105
None
1.00A 2bxgB-5cwcA:
3.7
2bxgB-5cwcA:
18.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
7 ALA A 209
ALA A 212
LEU A 330
LEU A 346
ALA A 349
SER A 479
LEU A 480
CZE  A 613 ( 4.4A)
CZE  A 613 ( 3.7A)
CZE  A 613 ( 4.2A)
CZE  A 613 ( 3.8A)
CZE  A 613 ( 4.7A)
None
None
0.60A 2bxgB-5dqfA:
49.6
2bxgB-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
7 ALA A 209
LEU A 330
LEU A 346
ALA A 349
LYS A 350
SER A 479
LEU A 480
CZE  A 613 ( 4.4A)
CZE  A 613 ( 4.2A)
CZE  A 613 ( 3.8A)
CZE  A 613 ( 4.7A)
CZE  A 613 (-4.1A)
None
None
0.88A 2bxgB-5dqfA:
49.6
2bxgB-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
5 ARG A 208
ALA A 209
ALA A 212
LEU A 330
LEU A 346
CZE  A 613 ( 3.5A)
CZE  A 613 ( 4.4A)
CZE  A 613 ( 3.7A)
CZE  A 613 ( 4.2A)
CZE  A 613 ( 3.8A)
0.83A 2bxgB-5dqfA:
49.6
2bxgB-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed7 TEGUMENT PROTEIN
UL21


(Human
alphaherpesvirus
1)
PF03252
(Herpes_UL21)
5 ALA A 401
ALA A 404
LEU A 459
LEU A 435
VAL A 520
None
1.02A 2bxgB-5ed7A:
2.4
2bxgB-5ed7A:
18.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
9 ALA A 210
ALA A 213
LEU A 331
LEU A 347
ALA A 350
LYS A 351
SER A 480
LEU A 481
VAL A 482
None
0.80A 2bxgB-5ghkA:
46.4
2bxgB-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hws 2-DEHYDROPANTOATE
2-REDUCTASE


(Thermococcus
kodakarensis)
PF02558
(ApbA)
PF08546
(ApbA_C)
5 LEU A 290
ALA A 293
LYS A 294
LEU A 194
VAL A 193
None
0.98A 2bxgB-5hwsA:
undetectable
2bxgB-5hwsA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp3 XANTHOMONAS OUTER
PROTEIN D


(Xanthomonas
euvesicatoria)
PF02902
(Peptidase_C48)
5 ALA A 425
LEU A 451
ALA A 446
SER A 411
LEU A 412
None
1.07A 2bxgB-5jp3A:
undetectable
2bxgB-5jp3A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY


(Myxococcus
xanthus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 175
LEU A 181
LEU A 207
ALA A 210
VAL A 215
None
1.04A 2bxgB-5k1sA:
undetectable
2bxgB-5k1sA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus)
PF07859
(Abhydrolase_3)
5 ALA A  85
ALA A 157
LEU A 161
ALA A 125
LEU A  88
None
0.86A 2bxgB-5l2pA:
undetectable
2bxgB-5l2pA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr6 XIAF PROTEIN

(Streptomyces
sp.)
PF08028
(Acyl-CoA_dh_2)
6 ALA A 236
ALA A 235
LEU A 317
LEU A 307
ALA A 310
VAL A  68
None
1.08A 2bxgB-5mr6A:
undetectable
2bxgB-5mr6A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN


(Segniliparus
rugosus)
PF00501
(AMP-binding)
PF00550
(PP-binding)
5 ALA A 216
ALA A 217
LEU A 198
LEU A 182
ALA A 185
None
1.01A 2bxgB-5mswA:
undetectable
2bxgB-5mswA:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 9 ARG A 208
ALA A 209
ALA A 212
LEU A 330
LEU A 346
ALA A 349
SER A 479
LEU A 480
VAL A 481
None
0.58A 2bxgB-5oriA:
49.1
2bxgB-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)


(Corynebacterium
freiburgense)
PF00171
(Aldedh)
PF01619
(Pro_dh)
5 ALA A 625
ALA A 628
LEU A 529
LEU A 600
ALA A 558
None
0.71A 2bxgB-5ux5A:
undetectable
2bxgB-5ux5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN


(Human
alphaherpesvirus
1)
PF03970
(Herpes_UL37_1)
5 ALA A 104
ALA A 107
LEU A  88
LEU A 152
ALA A 151
None
0.88A 2bxgB-5vylA:
undetectable
2bxgB-5vylA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1


(Streptococcus
pneumoniae)
PF00275
(EPSP_synthase)
5 ALA A 245
ALA A 247
LEU A 293
LEU A 385
VAL A 386
None
1.05A 2bxgB-5wi5A:
undetectable
2bxgB-5wi5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
no annotation 5 ARG A 319
LEU A 358
ALA A 329
LEU A 296
VAL A 297
None
1.04A 2bxgB-5wy4A:
undetectable
2bxgB-5wy4A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1


(Saccharomyces
cerevisiae)
no annotation 5 ALA G 318
LEU G 275
SER G 381
LEU G 379
VAL G 378
None
1.02A 2bxgB-5x6oG:
undetectable
2bxgB-5x6oG:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpz FERMITIN FAMILY
HOMOLOG 2


(Mus musculus)
PF00373
(FERM_M)
5 ALA A  86
ALA A  88
LEU A  90
LEU A  20
VAL A  35
None
1.02A 2bxgB-5xpzA:
3.6
2bxgB-5xpzA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE


(Bacteroides
thetaiotaomicron)
no annotation 5 ALA A 513
ALA A 464
SER A 446
LEU A 447
VAL A 448
None
0.81A 2bxgB-5xxoA:
2.3
2bxgB-5xxoA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194)
5 ALA C3987
ALA C3990
ALA C3780
SER C3906
LEU C3910
None
0.99A 2bxgB-5y3rC:
undetectable
2bxgB-5y3rC:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 7 ALA A 210
LEU A 331
LEU A 347
ALA A 350
SER A 480
LEU A 481
VAL A 482
None
0.67A 2bxgB-5yxeA:
46.8
2bxgB-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 8 ARG A 209
ALA A 210
ALA A 213
LEU A 331
LEU A 347
ALA A 350
LEU A 481
VAL A 482
None
0.54A 2bxgB-5yxeA:
46.8
2bxgB-5yxeA:
11.11