SIMILAR PATTERNS OF AMINO ACIDS FOR 2BXG_A_IBPA2002

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8s CHLOROPEROXIDASE F

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		4 ALA A 101
ALA A 115
LEU A 239
VAL A 240
 None
 0.73A 2bxgA-1a8sA:
undetectable		 2bxgA-1a8sA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)

(Malus domestica) 		PF00155
(Aminotran_1_2) 		4 ALA A  67
GLU A  64
SER A 314
LEU A 313
 None
 0.88A 2bxgA-1b8gA:
undetectable		 2bxgA-1b8gA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		4 ALA A 204
ALA A 321
GLU A 291
VAL A 214
 None
 0.89A 2bxgA-1cu1A:
1.6		 2bxgA-1cu1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89

(Zoogloea
ramigera) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ARG A 267
ALA A  42
GLU A  48
LEU A 258
 None
 0.88A 2bxgA-1dm3A:
0.0		 2bxgA-1dm3A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1z TNSA ENDONUCLEASE

(Escherichia
coli) 		PF08721
(Tn7_Tnp_TnsA_C)
PF08722
(Tn7_Tnp_TnsA_N) 		4 ARG A  54
GLU A  81
LEU A  77
VAL A  76
 None
 0.89A 2bxgA-1f1zA:
undetectable		 2bxgA-1f1zA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkx CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Mus musculus) 		PF08332
(CaMKII_AD) 		4 ALA A 379
ALA A 384
GLU A 383
LEU A 392
 None
 0.78A 2bxgA-1hkxA:
undetectable		 2bxgA-1hkxA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwa RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Galdieria
partita) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ARG A 421
ALA A 417
GLU A 234
VAL A 200
 None
 0.73A 2bxgA-1iwaA:
undetectable		 2bxgA-1iwaA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 ALA A 158
LYS A 157
LEU A  45
VAL A  44
 None
 0.90A 2bxgA-1kq3A:
undetectable		 2bxgA-1kq3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 ARG X 168
ALA X 164
GLU X 547
VAL X 563
 None
 0.82A 2bxgA-1mw9X:
undetectable		 2bxgA-1mw9X:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 ALA E 220
ALA E 241
LEU E 202
VAL E 203
 None
 0.75A 2bxgA-1nfiE:
undetectable		 2bxgA-1nfiE:
17.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 ARG A 209
ALA A 213
ALA A 350
GLU A 354
SER A 480
LEU A 481
VAL A 482
 DKA  A1001 ( 4.6A)
DKA  A1001 ( 4.0A)
DKA  A1002 ( 3.8A)
DKA  A1002 ( 4.4A)
DKA  A1002 (-3.4A)
None
DKA  A1002 (-4.2A)
 0.48A 2bxgA-1tf0A:
47.3		 2bxgA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttw SECRETION CHAPERONE

(Yersinia pestis) 		PF05932
(CesT) 		4 ARG A  80
SER A 111
LEU A 112
VAL A 108
 None
 0.91A 2bxgA-1ttwA:
undetectable		 2bxgA-1ttwA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ALA B 231
ALA B 318
LEU B 218
VAL B 217
 None
 0.91A 2bxgA-1umbB:
undetectable		 2bxgA-1umbB:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermus
thermophilus) 		PF00294
(PfkB) 		4 ALA A   7
ALA A 117
SER A 139
LEU A 138
 None
 0.72A 2bxgA-1v19A:
undetectable		 2bxgA-1v19A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Actinobacillus
succinogenes) 		PF01293
(PEPCK_ATP) 		4 ALA A 192
GLU A 197
LEU A 108
VAL A 109
 None
 0.75A 2bxgA-1yggA:
undetectable		 2bxgA-1yggA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		4 ARG A 151
ALA A 150
ALA A   7
GLU A   5
 None
 0.65A 2bxgA-1yirA:
undetectable		 2bxgA-1yirA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		4 ARG A 382
ALA A 386
LEU A 354
VAL A 355
 None
 0.89A 2bxgA-2b9eA:
undetectable		 2bxgA-2b9eA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4n HYPOTHETICAL PROTEIN
MJ1651

(Methanocaldococcus
jannaschii) 		PF01887
(SAM_adeno_trans) 		4 ARG A 131
ALA A 149
GLU A 150
VAL A  80
 None
 0.91A 2bxgA-2f4nA:
undetectable		 2bxgA-2f4nA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fc3 50S RIBOSOMAL
PROTEIN L7AE

(Aeropyrum
pernix) 		PF01248
(Ribosomal_L7Ae) 		4 ARG A  85
ALA A  89
GLU A  17
VAL A  52
 None
 0.70A 2bxgA-2fc3A:
undetectable		 2bxgA-2fc3A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs9 HYPOTHETICAL PROTEIN
TT1324

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		4 ARG A 203
GLU A 164
LEU A 134
VAL A 133
 None
 0.79A 2bxgA-2gs9A:
undetectable		 2bxgA-2gs9A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		4 ARG A 360
ALA A 354
GLU A 416
LEU A  26
 None
 0.90A 2bxgA-2gv8A:
undetectable		 2bxgA-2gv8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 ARG A 291
ALA A  43
GLU A  40
SER A 397
 None
 0.88A 2bxgA-2m56A:
undetectable		 2bxgA-2m56A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xro HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGV

(Pseudomonas
putida) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		4 ALA A  20
ALA A  56
LEU A  74
VAL A  63
 None
 0.89A 2bxgA-2xroA:
undetectable		 2bxgA-2xroA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		4 ALA C 115
ALA C  76
SER C 102
VAL C  37
 None
None
SF4  C1413 (-4.7A)
None
 0.80A 2bxgA-2ynmC:
undetectable		 2bxgA-2ynmC:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 ARG A 203
ALA A 205
GLU A  25
VAL A 188
 None
 0.91A 2bxgA-2yyzA:
undetectable		 2bxgA-2yyzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0j PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1438

(Thermus
thermophilus) 		PF04029
(2-ph_phosp) 		4 ALA A  82
GLU A  81
LEU A  61
VAL A  60
 None
 0.91A 2bxgA-2z0jA:
undetectable		 2bxgA-2z0jA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a58 GTP-BINDING PROTEIN
RHO1

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		4 ARG B 127
GLU B 163
SER B  96
LEU B  93
 None
 0.92A 2bxgA-3a58B:
undetectable		 2bxgA-3a58B:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 ARG A 314
ALA A 318
GLU A 254
VAL A 293
 LGU  A1002 (-4.3A)
None
LGU  A1002 (-4.5A)
None
 0.83A 2bxgA-3aflA:
2.3		 2bxgA-3aflA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3daf 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE

(Methanocaldococcus
jannaschii) 		PF03201
(HMD) 		4 ALA A  25
ALA A  48
LEU A 121
VAL A 122
 None
 0.88A 2bxgA-3dafA:
3.7		 2bxgA-3dafA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7t ENVELOPE PROTEIN

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		4 ALA A 117
ALA A 250
LYS A 248
LEU A 114
 None
 0.90A 2bxgA-3g7tA:
undetectable		 2bxgA-3g7tA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwr 2-DEHYDROPANTOATE
2-REDUCTASE

(Cupriavidus
pinatubonensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 ARG A 221
ALA A 220
GLU A 214
VAL A 231
 None
None
None
MRD  A 302 ( 4.8A)
 0.78A 2bxgA-3hwrA:
undetectable		 2bxgA-3hwrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1

(Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S) 		4 ALA 1 425
GLU 1 427
SER 1 336
VAL 1 338
 None
 0.89A 2bxgA-3i9v1:
undetectable		 2bxgA-3i9v1:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		4 ALA A 443
ALA A 129
LYS A 128
VAL A 436
 None
 0.81A 2bxgA-3j1cA:
undetectable		 2bxgA-3j1cA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Thermococcus
kodakarensis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ALA A 109
ALA A  27
LEU A 301
VAL A 300
 None
 0.90A 2bxgA-3kdnA:
undetectable		 2bxgA-3kdnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrh UNCHARACTERIZED
PROTEIN BF1032

(Bacteroides
fragilis) 		PF16702
(DUF5063) 		4 ARG A  35
GLU A  89
SER A 113
LEU A  83
 None
 0.92A 2bxgA-3nrhA:
undetectable		 2bxgA-3nrhA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyq MALONYL-COA LIGASE

(Streptomyces
coelicolor) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ALA A 138
ALA A 159
LEU A 191
VAL A 192
 None
 0.79A 2bxgA-3nyqA:
undetectable		 2bxgA-3nyqA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Roseovarius sp.
TM1035) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 257
ALA A 308
GLU A 335
LEU A 262
 None
None
None
RIB  A 433 (-4.7A)
 0.69A 2bxgA-3rcyA:
undetectable		 2bxgA-3rcyA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rob UNCHARACTERIZED
CONSERVED PROTEIN

(Planctopirus
limnophila) 		PF14534
(DUF4440) 		4 ARG A  32
LYS A  55
GLU A  56
LEU A  38
 None
 0.73A 2bxgA-3robA:
undetectable		 2bxgA-3robA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfw DIHYDROPYRIMIDINASE

(Brevibacillus
agri) 		PF01979
(Amidohydro_1) 		4 ARG A 451
ALA A 449
ALA A 435
GLU A  26
 None
 0.79A 2bxgA-3sfwA:
undetectable		 2bxgA-3sfwA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4w MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sulfitobacter
sp. NAS-14.1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 257
ALA A 308
GLU A 335
LEU A 262
 None
 0.71A 2bxgA-3t4wA:
undetectable		 2bxgA-3t4wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		4 ALA A  74
ALA A  21
LEU A 129
VAL A 128
 None
 0.91A 2bxgA-3ts7A:
2.0		 2bxgA-3ts7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 ALA A  52
ALA A 309
SER A 332
VAL A 329
 None
 0.66A 2bxgA-3u0kA:
undetectable		 2bxgA-3u0kA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vab DIAMINOPIMELATE
DECARBOXYLASE 1

(Brucella
melitensis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ALA A  14
GLU A  21
LEU A 394
VAL A 393
 None
 0.85A 2bxgA-3vabA:
undetectable		 2bxgA-3vabA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		4 ALA A  69
ALA A  16
LEU A 124
VAL A 123
 None
 0.89A 2bxgA-3zouA:
undetectable		 2bxgA-3zouA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 ALA A 486
SER A 497
LEU A 496
VAL A 516
 None
 0.70A 2bxgA-4ay2A:
3.6		 2bxgA-4ay2A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0s DEAMIDASE-DEPUPYLASE
DOP

(Acidothermus
cellulolyticus) 		PF03136
(Pup_ligase) 		4 ALA A 117
GLU A 119
LEU A 415
VAL A 416
 None
 0.91A 2bxgA-4b0sA:
undetectable		 2bxgA-4b0sA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 ARG A 854
GLU A 950
SER A 846
LEU A 845
 None
 0.86A 2bxgA-4bedA:
3.2		 2bxgA-4bedA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493

(Thermus
thermophilus) 		PF02475
(Met_10) 		4 ARG A 258
GLU A 177
LEU A 252
VAL A 225
 None
 0.86A 2bxgA-4dmgA:
undetectable		 2bxgA-4dmgA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4u MANDALATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 256
ALA A 307
GLU A 334
LEU A 261
 None
 0.78A 2bxgA-4e4uA:
undetectable		 2bxgA-4e4uA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Labrenzia
alexandrii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 262
ALA A 313
GLU A 340
LEU A 267
 None
 0.76A 2bxgA-4e5tA:
undetectable		 2bxgA-4e5tA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eah FORMIN-LIKE PROTEIN
3

(Mus musculus) 		PF02181
(FH2) 		4 ALA A 752
ALA A 836
LYS A 835
GLU A 834
 None
 0.80A 2bxgA-4eahA:
3.7		 2bxgA-4eahA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g09 HISTIDINOL
DEHYDROGENASE

(Brucella suis) 		PF00815
(Histidinol_dh) 		4 ARG A 342
ALA A 317
GLU A 315
VAL A 333
 None
 0.86A 2bxgA-4g09A:
undetectable		 2bxgA-4g09A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE

(Streptomyces
atroolivaceus) 		no annotation 4 ARG A 243
ALA A 247
GLU A 286
LEU A 235
 None
 0.92A 2bxgA-4hzpA:
undetectable		 2bxgA-4hzpA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 ARG A 268
ALA A 274
LYS A 273
GLU A 272
 None
 0.88A 2bxgA-4im7A:
undetectable		 2bxgA-4im7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqn PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF16728
(DUF5066) 		4 ALA C  54
SER C 162
LEU C 163
VAL C 164
 MLY  C  53 ( 3.6A)
None
None
None
 0.68A 2bxgA-4iqnC:
undetectable		 2bxgA-4iqnC:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 258
ALA A 308
GLU A 335
LEU A 263
 None
 0.71A 2bxgA-4j3zA:
undetectable		 2bxgA-4j3zA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 ALA A 172
ALA A 206
SER A 162
LEU A 163
 None
 0.76A 2bxgA-4jclA:
undetectable		 2bxgA-4jclA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k91 D-ALA-D-ALA-CARBOXYP
EPTIDASE

(Pseudomonas
aeruginosa) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 ALA A 237
ALA A  13
LEU A 214
VAL A 229
 None
 0.91A 2bxgA-4k91A:
undetectable		 2bxgA-4k91A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ljs PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		4 ARG A  62
ALA A  85
GLU A  25
LEU A 120
 None
 0.80A 2bxgA-4ljsA:
undetectable		 2bxgA-4ljsA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdv ANNEXIN

(Schistosoma
mansoni) 		PF00191
(Annexin) 		4 ALA A 188
SER A 165
LEU A 166
VAL A 167
 None
 0.54A 2bxgA-4mdvA:
undetectable		 2bxgA-4mdvA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1

(Homo sapiens) 		PF02205
(WH2)
PF05994
(FragX_IP)
PF07159
(DUF1394) 		4 ARG A 838
ALA D 100
GLU A 781
LEU D 511
 None
 0.75A 2bxgA-4n78A:
2.4		 2bxgA-4n78A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT

(Homo sapiens) 		PF12796
(Ank_2) 		4 ALA A 637
ALA A 659
LEU A 619
VAL A 620
 None
 0.87A 2bxgA-4ot9A:
2.4		 2bxgA-4ot9A:
21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		5 ALA A 213
GLU A 354
SER A 480
LEU A 481
VAL A 482
 NPS  A 602 (-3.3A)
NPS  A 602 ( 4.9A)
None
None
None
 0.60A 2bxgA-4po0A:
48.0		 2bxgA-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		4 ALA A 213
LYS A 351
SER A 480
LEU A 481
 NPS  A 602 (-3.3A)
None
None
None
 0.72A 2bxgA-4po0A:
48.0		 2bxgA-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		5 ARG A 209
ALA A 213
SER A 480
LEU A 481
VAL A 482
 NPS  A 602 (-3.6A)
NPS  A 602 (-3.3A)
None
None
None
 0.81A 2bxgA-4po0A:
48.0		 2bxgA-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 4 ARG A 151
ALA A  55
GLU A  57
VAL A 112
 None
 0.79A 2bxgA-4q38A:
undetectable		 2bxgA-4q38A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF04551
(GcpE) 		4 ARG A 184
ALA A 152
GLU A 156
LEU A 178
 None
 0.75A 2bxgA-4s38A:
undetectable		 2bxgA-4s38A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ALA A 323
ALA A 290
GLU A 289
VAL A 360
 None
 0.79A 2bxgA-4wz9A:
undetectable		 2bxgA-4wz9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcg THERMOSOME SUBUNIT
BETA

(Sulfolobus
solfataricus) 		PF00118
(Cpn60_TCP1) 		4 ALA B 445
ALA B 140
LYS B 139
VAL B 438
 None
 0.71A 2bxgA-4xcgB:
undetectable		 2bxgA-4xcgB:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
suis) 		PF01841
(Transglut_core) 		4 ALA A 427
SER A 419
LEU A 420
VAL A 421
 None
 0.83A 2bxgA-4xz7A:
undetectable		 2bxgA-4xz7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		4 ALA A 341
ALA A 329
LEU A 353
VAL A 352
 None
 0.88A 2bxgA-4yyfA:
undetectable		 2bxgA-4yyfA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ARG A 343
ALA A 651
GLU A 576
LEU A 646
 None
 0.92A 2bxgA-5a0zA:
undetectable		 2bxgA-5a0zA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afu DYNACTIN

(Sus scrofa) 		PF00022
(Actin) 		4 ALA A 149
SER A 331
LEU A 300
VAL A 299
 None
 0.84A 2bxgA-5afuA:
undetectable		 2bxgA-5afuA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz3 NA(+)/H(+)
ANTIPORTER

(Thermus
thermophilus) 		PF00999
(Na_H_Exchanger) 		4 ALA A  16
ALA A 274
LEU A  49
VAL A  50
 None
 0.83A 2bxgA-5bz3A:
undetectable		 2bxgA-5bz3A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwv NUCLEOPORIN NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 ALA A1641
SER A1608
LEU A1543
VAL A1610
 None
 0.91A 2bxgA-5cwvA:
undetectable		 2bxgA-5cwvA:
20.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 ALA A 212
ALA A 349
GLU A 353
SER A 479
LEU A 480
 CZE  A 613 ( 3.7A)
CZE  A 613 ( 4.7A)
CZE  A 613 (-2.9A)
None
None
 0.76A 2bxgA-5dqfA:
48.9		 2bxgA-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 ALA A 349
LYS A 350
GLU A 353
SER A 479
LEU A 480
 CZE  A 613 ( 4.7A)
CZE  A 613 (-4.1A)
CZE  A 613 (-2.9A)
None
None
 0.87A 2bxgA-5dqfA:
48.9		 2bxgA-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5et1 ESPIN

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 ALA A 243
ALA A 264
LEU A 225
VAL A 226
 None
 0.72A 2bxgA-5et1A:
undetectable		 2bxgA-5et1A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		4 ARG A 557
ALA A 558
ALA A 412
LEU A 548
 None
 0.85A 2bxgA-5fnoA:
undetectable		 2bxgA-5fnoA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5u BETA-HEXOSAMINIDASE

(Pseudomonas
aeruginosa) 		PF00933
(Glyco_hydro_3) 		4 ALA A 208
ALA A 169
SER A 190
LEU A 192
 None
 0.77A 2bxgA-5g5uA:
undetectable		 2bxgA-5g5uA:
19.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		6 ALA A 213
ALA A 350
LYS A 351
GLU A 354
SER A 480
VAL A 482
 None
 0.81A 2bxgA-5ghkA:
45.7		 2bxgA-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		6 ALA A 350
LYS A 351
GLU A 354
SER A 480
LEU A 481
VAL A 482
 None
 0.82A 2bxgA-5ghkA:
45.7		 2bxgA-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d PUTRESCINE
AMINOTRANSFERASE,IMM
UNOGLOBULIN
G-BINDING PROTEIN A

(Escherichia
coli;
Staphylococcus
aureus) 		PF00202
(Aminotran_3)
PF02216
(B) 		4 ARG A 446
ALA A 445
LEU A 380
VAL A 381
 None
 0.72A 2bxgA-5h7dA:
undetectable		 2bxgA-5h7dA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA

(Homo sapiens) 		PF08332
(CaMKII_AD) 		4 ALA A 379
ALA A 384
GLU A 383
LEU A 392
 None
 0.91A 2bxgA-5ig3A:
undetectable		 2bxgA-5ig3A:
11.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 5 ALA A 212
ALA A 349
GLU A 353
LEU A 480
VAL A 481
 None
 0.49A 2bxgA-5oriA:
48.5		 2bxgA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 5 ALA A 212
ALA A 349
SER A 479
LEU A 480
VAL A 481
 None
 0.51A 2bxgA-5oriA:
48.5		 2bxgA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 5 ARG A 208
ALA A 212
ALA A 349
GLU A 353
LEU A 480
 None
 0.42A 2bxgA-5oriA:
48.5		 2bxgA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owo CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		no annotation 4 ALA A  55
GLU A  53
LEU A  37
VAL A  38
 None
 0.92A 2bxgA-5owoA:
2.2		 2bxgA-5owoA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR

(Escherichia
coli;
Homo sapiens) 		no annotation 4 ALA A 340
ALA A 372
GLU A 373
VAL A 183
 None
 0.83A 2bxgA-5v6yA:
3.3		 2bxgA-5v6yA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 4 ALA A 463
ALA A 438
LEU A 405
VAL A 404
 None
 0.80A 2bxgA-5wabA:
undetectable		 2bxgA-5wabA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 4 ARG A 265
ALA A 264
ALA A  18
GLU A  15
 None
 0.88A 2bxgA-5wabA:
undetectable		 2bxgA-5wabA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrp PYRUVATE KINASE

(Mycobacterium
tuberculosis) 		no annotation 4 ARG A 438
ALA A 369
GLU A 412
VAL A 429
 None
 0.70A 2bxgA-5wrpA:
undetectable		 2bxgA-5wrpA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 4 ALA A 229
SER A  35
LEU A  36
VAL A  37
 None
FAD  A 701 (-3.3A)
FAD  A 701 (-3.7A)
FAD  A 701 ( 4.9A)
 0.65A 2bxgA-5xmjA:
undetectable		 2bxgA-5xmjA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 ALA A 350
GLU A 354
SER A 480
LEU A 481
VAL A 482
 None
 0.44A 2bxgA-5yxeA:
47.0		 2bxgA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 ARG A 209
ALA A 213
ALA A 350
GLU A 354
LEU A 481
VAL A 482
 None
 0.56A 2bxgA-5yxeA:
47.0		 2bxgA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azi D-ALANYL-D-ALANINE
ENDOPEPTIDASE

(Enterobacter
cloacae) 		PF00768
(Peptidase_S11) 		4 ALA A 269
ALA A  40
LEU A 243
VAL A 258
 None
 0.85A 2bxgA-6aziA:
undetectable		 2bxgA-6aziA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bar ROD SHAPE
DETERMINING PROTEIN
RODA

(Thermus
thermophilus) 		no annotation 4 ALA A 119
LYS A 120
GLU A 123
LEU A  68
 None
 0.76A 2bxgA-6barA:
undetectable		 2bxgA-6barA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae) 		no annotation 4 ALA A 106
GLU A 102
LEU A  30
VAL A  29
 None
 0.77A 2bxgA-6brdA:
undetectable		 2bxgA-6brdA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 4 ALA X 442
ALA X 570
LEU X 534
VAL X 535
 None
 0.75A 2bxgA-6elqX:
undetectable		 2bxgA-6elqX:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 4 ALA C 716
GLU C 722
LEU C 686
VAL C 687
 None
 0.85A 2bxgA-6en4C:
2.8		 2bxgA-6en4C:
9.03