SIMILAR PATTERNS OF AMINO ACIDS FOR 2BXG_A_IBPA2001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ASN A 249
VAL A 232
GLY A 229
ALA A 247
ARG A 220
 None
 1.17A 2bxgA-1lxtA:
undetectable		 2bxgA-1lxtA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 LEU A 241
VAL A 248
GLY A 249
ALA A 338
LEU A 339
 None
 1.16A 2bxgA-1q5nA:
2.2		 2bxgA-1q5nA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgo ANAEROBIC COBALAMIN
BIOSYNTHETIC COBALT
CHELATASE

(Salmonella
enterica) 		PF06180
(CbiK) 		5 ASN A 225
VAL A 195
GLY A 194
LEU A 197
SER A 219
 None
 1.24A 2bxgA-1qgoA:
undetectable		 2bxgA-1qgoA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		5 LEU A 158
VAL A 166
GLY A 167
ALA A 374
LEU A 186
 None
 1.22A 2bxgA-1sjpA:
2.6		 2bxgA-1sjpA:
24.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 LEU A 387
ASN A 391
ARG A 410
LYS A 414
GLY A 434
ALA A 449
LEU A 453
 None
 0.88A 2bxgA-1tf0A:
47.3		 2bxgA-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LEU A 387
ASN A 391
GLY A 431
LEU A 453
ARG A 485
 None
 1.27A 2bxgA-1tf0A:
47.3		 2bxgA-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		9 LEU A 387
ASN A 391
TYR A 411
LYS A 414
GLY A 434
ALA A 449
LEU A 453
ARG A 485
SER A 489
 None
 0.67A 2bxgA-1tf0A:
47.3		 2bxgA-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		9 LEU A 387
TYR A 411
LYS A 414
VAL A 433
GLY A 434
ALA A 449
LEU A 453
ARG A 485
SER A 489
 None
 0.73A 2bxgA-1tf0A:
47.3		 2bxgA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		5 VAL C 528
GLY C 529
ALA C 539
LEU C 540
ARG C 588
 None
 1.25A 2bxgA-1u6gC:
2.4		 2bxgA-1u6gC:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		5 VAL A 667
GLY A 666
ALA A 275
LEU A 278
ARG A 283
 None
 1.17A 2bxgA-1ulvA:
undetectable		 2bxgA-1ulvA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgg CONSERVED
HYPOTHETICAL PROTEIN
TT1634 (TTHA1091)

(Thermus
thermophilus) 		PF04008
(Adenosine_kin) 		5 LEU A  83
VAL A 132
GLY A 131
ALA A 110
LEU A 116
 None
 1.27A 2bxgA-1vggA:
undetectable		 2bxgA-1vggA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vho ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		5 LEU A 185
VAL A 177
GLY A 176
ALA A 322
LEU A 325
 LEU  A 185 ( 0.6A)
VAL  A 177 ( 0.6A)
GLY  A 176 ( 0.0A)
ALA  A 322 ( 0.0A)
LEU  A 325 ( 0.6A)
 1.26A 2bxgA-1vhoA:
undetectable		 2bxgA-1vhoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE

(Pseudomonas
putida;
Spinacia
oleracea) 		PF01070
(FMN_dh) 		5 LEU A  86
VAL A 322
GLY A 321
ALA A  93
LEU A  94
 None
 1.13A 2bxgA-2a7nA:
undetectable		 2bxgA-2a7nA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axo HYPOTHETICAL PROTEIN
ATU2684

(Agrobacterium
fabrum) 		PF06764
(DUF1223) 		5 TYR A 104
VAL A  74
GLY A  75
ALA A 235
LEU A 237
 None
 1.16A 2bxgA-2axoA:
undetectable		 2bxgA-2axoA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		5 ARG A  83
VAL A  66
ALA A  64
LEU A 108
SER A  84
 None
 1.16A 2bxgA-2exrA:
undetectable		 2bxgA-2exrA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzm GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		5 VAL A 113
GLY A 114
ALA A 104
LEU A 105
SER A 133
 None
 1.16A 2bxgA-2gzmA:
undetectable		 2bxgA-2gzmA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 LEU A 925
VAL A 897
GLY A 898
ALA A 934
LEU A 938
 None
 1.04A 2bxgA-2hpiA:
2.4		 2bxgA-2hpiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lf3 EFFECTOR PROTEIN
HOPAB3

(Pseudomonas
syringae group
genomosp. 3) 		PF16847
(AvrPtoB_bdg) 		5 LEU A 333
VAL A 354
GLY A 355
ALA A 315
LEU A 319
 None
 1.11A 2bxgA-2lf3A:
undetectable		 2bxgA-2lf3A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ome C-TERMINAL-BINDING
PROTEIN 2

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 VAL A  36
GLY A  78
ALA A  55
LEU A  51
ARG A 342
 None
 1.23A 2bxgA-2omeA:
undetectable		 2bxgA-2omeA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 VAL A 505
GLY A 504
ALA A 500
LEU A 494
ARG A 497
 None
 1.13A 2bxgA-2qo3A:
undetectable		 2bxgA-2qo3A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz6 BETA-LACTAMASE

(Pseudomonas
fluorescens) 		PF00144
(Beta-lactamase) 		5 LEU A 283
ASN A 314
VAL A 336
ALA A 353
LEU A 357
 None
 1.18A 2bxgA-2qz6A:
undetectable		 2bxgA-2qz6A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		5 VAL A 387
ALA A 393
LEU A 396
ARG A 301
SER A 263
 None
 1.26A 2bxgA-2vroA:
undetectable		 2bxgA-2vroA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wf7 BETA-PHOSPHOGLUCOMUT
ASE

(Lactococcus
lactis) 		PF13419
(HAD_2) 		5 VAL A 158
GLY A 159
ALA A   4
LEU A   6
SER A 181
 None
 1.14A 2bxgA-2wf7A:
2.1		 2bxgA-2wf7A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		5 VAL A 335
GLY A 334
ALA A 385
LEU A 394
SER A 409
 None
 1.08A 2bxgA-2xsgA:
2.3		 2bxgA-2xsgA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0f PUTATIVE
PHOSPHOGLUCOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 169
TYR A  10
VAL A  24
GLY A  23
ALA A 161
 None
 1.10A 2bxgA-2z0fA:
undetectable		 2bxgA-2z0fA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bge PREDICTED ATPASE

(Haemophilus
influenzae) 		PF12002
(MgsA_C) 		5 LEU A 295
VAL A 302
GLY A 303
ALA A 309
LEU A 339
 None
 1.27A 2bxgA-3bgeA:
2.4		 2bxgA-3bgeA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3y O-METHYLTRANSFERASE

(Mesembryanthemum
crystallinum) 		PF01596
(Methyltransf_3) 		5 VAL A  77
GLY A  78
ALA A 131
LEU A 135
ARG A 166
 None
SAH  A 464 (-3.7A)
SAH  A 464 (-3.5A)
None
None
 1.11A 2bxgA-3c3yA:
undetectable		 2bxgA-3c3yA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8t FUMARATE LYASE

(Chelativorans
sp. BNC1) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 LEU A 135
VAL A 254
ALA A 345
LEU A 349
ARG A 139
 None
 1.28A 2bxgA-3c8tA:
2.7		 2bxgA-3c8tA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Bacillus
halodurans) 		PF13460
(NAD_binding_10) 		5 ASN A   9
VAL A   5
ALA A  13
LEU A  17
ARG A  43
 NAP  A 500 (-3.6A)
None
None
None
None
 1.05A 2bxgA-3e8xA:
undetectable		 2bxgA-3e8xA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gab DNA MISMATCH REPAIR
PROTEIN MUTL

(Bacillus
subtilis) 		PF08676
(MutL_C) 		5 VAL A 515
GLY A 516
ALA A 567
LEU A 563
SER A 555
 None
 1.27A 2bxgA-3gabA:
2.1		 2bxgA-3gabA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpr RHODOCETIN SUBUNIT
DELTA

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		5 LEU D4058
VAL D4050
GLY D4051
LEU D4119
SER D4117
 None
 1.26A 2bxgA-3gprD:
undetectable		 2bxgA-3gprD:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		5 LEU A 363
VAL A 392
GLY A 391
ALA A 387
LEU A 397
 None
 1.27A 2bxgA-3i5gA:
3.2		 2bxgA-3i5gA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS

(Vibrio
parahaemolyticus) 		PF02661
(Fic) 		5 LEU A 137
GLY A 176
ALA A 182
LEU A 116
SER A  96
 None
 1.15A 2bxgA-3letA:
undetectable		 2bxgA-3letA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS

(Vibrio
parahaemolyticus) 		PF02661
(Fic) 		5 LEU A 137
GLY A 177
ALA A 182
LEU A 116
SER A  96
 None
 1.22A 2bxgA-3letA:
undetectable		 2bxgA-3letA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lml LIN1278 PROTEIN

(Listeria
innocua) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		5 LEU A 102
VAL A 150
GLY A 151
ALA A 153
LEU A 156
 None
 1.26A 2bxgA-3lmlA:
undetectable		 2bxgA-3lmlA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1t PUTATIVE
PHOSPHOHYDROLASE

(Shewanella
amazonensis) 		PF08668
(HDOD) 		5 LEU A  84
VAL A  66
GLY A  67
ALA A  72
LEU A  76
 None
 1.15A 2bxgA-3m1tA:
undetectable		 2bxgA-3m1tA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3md0 ARGININE/ORNITHINE
TRANSPORT SYSTEM
ATPASE

(Mycobacterium
tuberculosis) 		PF03308
(ArgK) 		5 LEU A 221
VAL A 194
GLY A 193
ALA A 198
LEU A 177
 None
 1.20A 2bxgA-3md0A:
undetectable		 2bxgA-3md0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 LEU A 397
TYR A 417
VAL A 261
GLY A  14
ALA A 254
 None
 1.23A 2bxgA-3nvsA:
undetectable		 2bxgA-3nvsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE

(Pseudomonas
aeruginosa) 		PF01048
(PNP_UDP_1) 		5 VAL A 197
GLY A 198
ALA A 173
LEU A 189
ARG A 188
 HPA  A 260 (-4.3A)
HPA  A 260 (-3.3A)
None
None
None
 1.19A 2bxgA-3ozbA:
undetectable		 2bxgA-3ozbA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6g LIGHT CHAIN OF FAB
OF RHESUS MAB 2.5B

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU L  73
VAL L  78
GLY L  77
ALA L  19
LEU L 104
 None
 1.13A 2bxgA-3q6gL:
undetectable		 2bxgA-3q6gL:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 182
ARG A 166
VAL A 188
GLY A 186
LEU A 196
 None
 1.26A 2bxgA-3rr1A:
undetectable		 2bxgA-3rr1A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrk V-TYPE ATPASE 116
KDA SUBUNIT

(Meiothermus
ruber) 		no annotation 5 ARG A 260
TYR A 261
VAL A  55
ALA A  84
LEU A  81
 None
 1.20A 2bxgA-3rrkA:
2.5		 2bxgA-3rrkA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3

(Coxiella
burnetii) 		PF00009
(GTP_EFTU)
PF16658
(RF3_C) 		5 VAL A 261
GLY A 260
ALA A 255
LEU A  26
SER A  17
 None
None
GDP  A 527 (-4.2A)
None
GDP  A 527 ( 4.4A)
 1.17A 2bxgA-3tr5A:
undetectable		 2bxgA-3tr5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 VAL A 147
GLY A 148
ALA A 234
ARG A 484
SER A 481
 None
 1.19A 2bxgA-3v4cA:
3.6		 2bxgA-3v4cA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
ALPHA

(Mammuthus
primigenius) 		PF00042
(Globin) 		5 VAL A  25
GLY A  59
ALA A  28
LEU A 105
SER A 133
 None
None
None
None
HEM  A 201 ( 4.2A)
 1.27A 2bxgA-3vreA:
2.7		 2bxgA-3vreA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzi ACETYLGLUTAMATE
KINASE

(Saccharomyces
cerevisiae) 		PF00696
(AA_kinase)
PF04768
(NAT) 		5 LEU A 179
VAL A 188
GLY A 187
ALA A 190
LEU A 231
 None
 1.21A 2bxgA-3zziA:
undetectable		 2bxgA-3zziA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aiz V2-17 PROTEIN

(Homo sapiens) 		PF07686
(V-set) 		5 LEU A  72
VAL A  77
GLY A  76
ALA A  18
LEU A 105
 None
 1.12A 2bxgA-4aizA:
undetectable		 2bxgA-4aizA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		5 LEU A 348
VAL A  96
GLY A 325
ALA A  93
LEU A  78
 None
 1.24A 2bxgA-4au2A:
undetectable		 2bxgA-4au2A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 VAL A 183
GLY A 184
ALA A  92
LEU A  96
SER A 127
 None
 1.08A 2bxgA-4bkmA:
undetectable		 2bxgA-4bkmA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkb DEOXYURIDINE
TRIPHOSPHATASE

(Trypanosoma
brucei) 		PF08761
(dUTPase_2) 		5 LEU A 238
ASN A 235
ARG A 215
TYR A 225
VAL A 232
 None
DUN  A 303 (-3.9A)
DUN  A 303 (-2.8A)
None
None
 1.15A 2bxgA-4dkbA:
2.4		 2bxgA-4dkbA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewg BETA-KETOACYL
SYNTHASE

(Paraburkholderia
phymatum) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A 239
GLY A   8
LEU A 185
ARG A 100
SER A  95
 None
 1.21A 2bxgA-4ewgA:
undetectable		 2bxgA-4ewgA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j07 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Mycobacterium
leprae) 		PF00885
(DMRL_synthase) 		5 VAL A  77
GLY A 113
ALA A  75
LEU A  20
SER A  46
 None
 1.23A 2bxgA-4j07A:
2.1		 2bxgA-4j07A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4y TRANSCRIPTIONAL
REGULATOR LSRR

(Escherichia
coli) 		PF04198
(Sugar-bind) 		5 LEU A 132
VAL A 280
GLY A 281
ALA A 106
LEU A 110
 None
 0.76A 2bxgA-4l4yA:
undetectable		 2bxgA-4l4yA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5i TRANSCRIPTIONAL
REGULATOR LSRR

(Escherichia
coli) 		PF04198
(Sugar-bind) 		5 LEU A 132
VAL A 280
GLY A 281
ALA A 106
LEU A 110
 None
 0.88A 2bxgA-4l5iA:
undetectable		 2bxgA-4l5iA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Homo sapiens) 		PF01008
(IF-2B) 		5 VAL A 184
GLY A 183
ALA A 148
LEU A 151
SER A 241
 None
 1.24A 2bxgA-4ldqA:
2.7		 2bxgA-4ldqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obs ALPHA-L-IDURONIDASE

(Homo sapiens) 		PF01229
(Glyco_hydro_39) 		5 LEU A 353
VAL A  88
GLY A  51
LEU A  74
SER A  67
 None
 1.15A 2bxgA-4obsA:
undetectable		 2bxgA-4obsA:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		10 LEU A 387
ASN A 391
ARG A 410
TYR A 411
LYS A 414
VAL A 433
GLY A 434
LEU A 453
ARG A 485
SER A 489
 NPS  A 601 ( 4.7A)
NPS  A 601 (-4.3A)
NPS  A 601 (-4.5A)
NPS  A 601 (-4.3A)
NPS  A 601 (-2.7A)
None
None
NPS  A 601 (-4.7A)
None
NPS  A 601 (-3.1A)
 0.59A 2bxgA-4po0A:
48.0		 2bxgA-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqq HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
LIGHT CHAIN

(Homo sapiens) 		no annotation 5 ARG L  42
VAL L  58
GLY L  57
ALA L  55
LEU L  47
 None
 1.21A 2bxgA-4rqqL:
undetectable		 2bxgA-4rqqL:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE

(Homo sapiens) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 VAL A 353
GLY A 354
LEU A 344
ARG A 343
SER A 417
 None
None
None
BES  A 501 (-2.5A)
BES  A 501 (-4.4A)
 1.24A 2bxgA-4ruhA:
undetectable		 2bxgA-4ruhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		5 VAL A 104
GLY A 101
ALA A 121
LEU A  92
SER A  68
 None
 1.13A 2bxgA-4rweA:
undetectable		 2bxgA-4rweA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s13 FERULIC ACID
DECARBOXYLASE 1

(Saccharomyces
cerevisiae) 		PF01977
(UbiD) 		5 LEU A 347
VAL A 395
GLY A 396
ALA A 338
LEU A 341
 None
 1.14A 2bxgA-4s13A:
undetectable		 2bxgA-4s13A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 264
ARG A 277
VAL A 300
GLY A 301
ALA A 472
 None
 1.28A 2bxgA-4udrA:
undetectable		 2bxgA-4udrA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wau CENTROMERE PROTEIN M

(Homo sapiens) 		PF11111
(CENP-M) 		5 VAL A  69
GLY A  22
LEU A 133
ARG A 139
SER A  34
 None
 1.19A 2bxgA-4wauA:
undetectable		 2bxgA-4wauA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydi ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		5 LEU G 342
ASN G 339
VAL G 333
LEU G 390
SER G 393
 None
 1.26A 2bxgA-4ydiG:
undetectable		 2bxgA-4ydiG:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		5 ARG A 301
VAL A 155
GLY A 154
ALA A 167
LEU A 511
 NSQ  A1681 (-3.1A)
CA  A1679 ( 4.7A)
CA  A1679 (-4.6A)
None
None
 1.16A 2bxgA-5aeeA:
undetectable		 2bxgA-5aeeA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		5 ARG A 301
VAL A 155
GLY A 154
LEU A 511
SER A 297
 NSQ  A1681 (-3.1A)
CA  A1679 ( 4.7A)
CA  A1679 (-4.6A)
None
None
 1.22A 2bxgA-5aeeA:
undetectable		 2bxgA-5aeeA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomyces
pombe) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		5 LEU I  36
VAL I 406
GLY I 405
ALA I 403
SER I 425
 None
 1.16A 2bxgA-5b04I:
undetectable		 2bxgA-5b04I:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt1 HAT1-INTERACTING
FACTOR 1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 260
VAL A 293
ALA A 289
LEU A 290
ARG A 304
 None
 1.28A 2bxgA-5bt1A:
3.9		 2bxgA-5bt1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv0 VPS16

(Chaetomium
thermophilum) 		PF04840
(Vps16_C) 		5 VAL B 564
ALA B 548
LEU B 549
ARG B 584
SER B 583
 None
 1.28A 2bxgA-5bv0B:
undetectable		 2bxgA-5bv0B:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cml OSMC FAMILY PROTEIN

(Rhodothermus
marinus) 		PF12146
(Hydrolase_4) 		5 LEU A  54
VAL A 252
GLY A 253
ALA A  30
LEU A 104
 None
 1.26A 2bxgA-5cmlA:
undetectable		 2bxgA-5cmlA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgt BENZOYLFORMATE
DECARBOXYLASE

(Pseudomonas
putida) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 TYR A  41
VAL A  51
GLY A  52
ALA A  78
LEU A  69
 None
 1.19A 2bxgA-5dgtA:
undetectable		 2bxgA-5dgtA:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		9 LEU A 386
ASN A 390
ARG A 409
TYR A 410
LYS A 413
VAL A 432
GLY A 433
ARG A 484
SER A 488
 None
 0.68A 2bxgA-5dqfA:
48.9		 2bxgA-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		8 LEU A 386
ASN A 390
LYS A 413
VAL A 432
GLY A 433
LEU A 452
ARG A 484
SER A 488
 None
 0.64A 2bxgA-5dqfA:
48.9		 2bxgA-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		7 LEU A 386
ASN A 390
VAL A 432
GLY A 430
LEU A 452
ARG A 484
SER A 488
 None
 1.47A 2bxgA-5dqfA:
48.9		 2bxgA-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du2 ESPG2
GLYCOSYLTRANSFERASE

(Actinomadura
verrucosospora) 		PF00201
(UDPGT) 		5 ARG A  33
VAL A 210
GLY A 382
ALA A 208
LEU A 189
 None
 1.20A 2bxgA-5du2A:
undetectable		 2bxgA-5du2A:
20.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		11 LEU A 387
ASN A 391
ARG A 410
TYR A 411
LYS A 414
VAL A 433
GLY A 434
ALA A 449
LEU A 453
ARG A 485
SER A 489
 None
 0.63A 2bxgA-5ghkA:
45.7		 2bxgA-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwo PROBABLE PROTEIN
PHOSPHATASE 2C 50

(Oryza sativa) 		PF00481
(PP2C) 		5 LEU A 234
ARG A 227
VAL A 208
ALA A 206
LEU A 301
 None
 1.19A 2bxgA-5gwoA:
2.0		 2bxgA-5gwoA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqn PROTEIN FIMG

(Escherichia
coli) 		no annotation 5 LEU A  27
GLY A  79
ALA A 135
LEU A  86
SER A  42
 None
 1.17A 2bxgA-5iqnA:
undetectable		 2bxgA-5iqnA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j60 THIOREDOXIN
REDUCTASE

(Gloeobacter
violaceus) 		PF07992
(Pyr_redox_2) 		5 TYR A 237
VAL A 171
ALA A 168
LEU A 164
SER A 133
 None
 1.25A 2bxgA-5j60A:
undetectable		 2bxgA-5j60A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425) 		PF00881
(Nitroreductase) 		5 LEU A 400
VAL A 459
ALA A 395
LEU A 334
SER A 327
 None
 1.10A 2bxgA-5lq4A:
undetectable		 2bxgA-5lq4A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m9n TUDOR
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00567
(TUDOR) 		5 VAL A 573
GLY A 574
ALA A 549
LEU A 584
ARG A 588
 None
EDO  A 702 ( 3.8A)
None
None
None
 1.01A 2bxgA-5m9nA:
undetectable		 2bxgA-5m9nA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		5 ARG A 240
GLY A 336
ALA A 144
LEU A 294
SER A 286
 None
 1.19A 2bxgA-5o1mA:
undetectable		 2bxgA-5o1mA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1t PROTEIN NRD1

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		5 LEU A 341
VAL A 346
GLY A 345
ALA A 377
LEU A 355
 None
 1.06A 2bxgA-5o1tA:
undetectable		 2bxgA-5o1tA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oev GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 22
(GPA-GSS22-APO)

(Globodera
pallida) 		no annotation 5 VAL A  54
GLY A 481
ALA A  52
LEU A  35
ARG A 166
 None
 1.04A 2bxgA-5oevA:
undetectable		 2bxgA-5oevA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 5 ARG A 283
VAL A 138
GLY A 137
LEU A 494
SER A 279
 NSQ  A 709 (-3.3A)
None
None
MPD  A 705 ( 4.5A)
MPD  A 705 ( 3.9A)
 1.13A 2bxgA-5ohsA:
undetectable		 2bxgA-5ohsA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 8 ARG A 409
TYR A 410
LYS A 413
VAL A 432
GLY A 433
LEU A 452
ARG A 484
SER A 488
 None
 0.69A 2bxgA-5oriA:
48.5		 2bxgA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 8 ASN A 390
ARG A 409
TYR A 410
LYS A 413
GLY A 433
LEU A 452
ARG A 484
SER A 488
 None
 0.62A 2bxgA-5oriA:
48.5		 2bxgA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 7 LEU A 386
ASN A 390
TYR A 410
LYS A 413
GLY A 433
LEU A 452
SER A 488
 None
 0.84A 2bxgA-5oriA:
48.5		 2bxgA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 7 LEU A 386
TYR A 410
LYS A 413
VAL A 432
GLY A 433
LEU A 452
SER A 488
 None
 0.87A 2bxgA-5oriA:
48.5		 2bxgA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9z PHOSPHOGLYCEROL
TRANSFERASE

(Streptococcus
pyogenes) 		no annotation 5 LEU A 683
ASN A 649
TYR A 627
VAL A 617
GLY A 618
 None
 1.27A 2bxgA-5u9zA:
undetectable		 2bxgA-5u9zA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usd PEPTIDASE S66

(Bacillus
anthracis) 		PF02016
(Peptidase_S66) 		5 LEU A  99
ASN A 103
VAL A  76
ALA A  70
ARG A  72
 None
 1.14A 2bxgA-5usdA:
undetectable		 2bxgA-5usdA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8l PGT145 ANTIBODY,
LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 ARG N  39
VAL N  58
GLY N  57
ALA N  55
LEU N  47
 None
 1.28A 2bxgA-5v8lN:
undetectable		 2bxgA-5v8lN:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		5 LEU A 787
ASN A 791
TYR A 616
VAL A 795
GLY A 794
 None
 1.14A 2bxgA-5welA:
3.4		 2bxgA-5welA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yrp SENSORY BOX/RESPONSE
REGULATOR

(Mycolicibacterium
smegmatis) 		no annotation 5 LEU A 560
VAL A 565
GLY A 564
ALA A 582
LEU A 574
 None
 1.17A 2bxgA-5yrpA:
undetectable		 2bxgA-5yrpA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 10 ASN A 391
ARG A 410
TYR A 411
LYS A 414
VAL A 433
GLY A 434
ALA A 449
LEU A 453
ARG A 485
SER A 489
 None
 0.85A 2bxgA-5yxeA:
47.0		 2bxgA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 10 LEU A 387
ASN A 391
TYR A 411
LYS A 414
VAL A 433
GLY A 434
ALA A 449
LEU A 453
ARG A 485
SER A 489
 None
 0.83A 2bxgA-5yxeA:
47.0		 2bxgA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1d UNCONVENTIONAL
MYOSIN-IB

(Rattus
norvegicus) 		no annotation 5 TYR P  78
VAL P  17
GLY P  16
LEU P  22
ARG P 691
 None
 1.26A 2bxgA-6c1dP:
2.5		 2bxgA-6c1dP:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci7 YCAO

(Methanopyrus
kandleri) 		no annotation 5 VAL A 220
GLY A 237
ALA A 222
LEU A 207
ARG A 195
 None
 1.19A 2bxgA-6ci7A:
undetectable		 2bxgA-6ci7A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cuf -

(-) 		no annotation 5 ARG 7  39
VAL 7  58
GLY 7  57
ALA 7  55
LEU 7  47
 None
 1.06A 2bxgA-6cuf7:
undetectable		 2bxgA-6cuf7:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxd PEPTIDASE B

(Yersinia pestis) 		no annotation 5 LEU A 427
VAL A 419
GLY A 418
ALA A 229
LEU A 232
 None
 1.14A 2bxgA-6cxdA:
undetectable		 2bxgA-6cxdA:
7.98