SIMILAR PATTERNS OF AMINO ACIDS FOR 2BXF_B_DZPB2001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)


(Hordeum vulgare)
PF01373
(Glyco_hydro_14)
5 ILE A 294
ASN A 338
LEU A 411
VAL A 375
LEU A 365
None
1.15A 2bxfB-1b1yA:
undetectable
2bxfB-1b1yA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6v CHIMERIC GERMLINE
PRECURSOR OF
OXY-COPE CATALYTIC
ANTIBODY AZ-28
(LIGHT CHAIN)


(Homo sapiens;
Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 TYR L  86
LEU L 104
GLU L  79
LEU L  78
ARG L  61
None
None
CD  L 501 (-2.4A)
None
CD  L 504 ( 4.3A)
1.33A 2bxfB-1d6vL:
undetectable
2bxfB-1d6vL:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jm7 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN


(Homo sapiens)
PF00097
(zf-C3HC4)
5 ILE A  21
LEU A  87
VAL A  83
GLU A  23
LEU A  30
None
1.33A 2bxfB-1jm7A:
undetectable
2bxfB-1jm7A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE


(Arabidopsis
thaliana)
PF16363
(GDP_Man_Dehyd)
5 ILE A  70
LEU A  84
VAL A  55
GLU A  46
LEU A  49
None
1.03A 2bxfB-1n7gA:
undetectable
2bxfB-1n7gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE


(Aeropyrum
pernix)
PF01791
(DeoC)
5 LEU A  29
LEU A  67
VAL A  73
CYH A  53
GLU A  45
None
1.30A 2bxfB-1n7kA:
undetectable
2bxfB-1n7kA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN


(Salmonella
enterica)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N)
5 LEU A 512
ASN A 580
LEU A 442
GLU A 436
ARG A 440
None
1.32A 2bxfB-1pemA:
2.7
2bxfB-1pemA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qap QUINOLINIC ACID
PHOSPHORIBOSYLTRANSF
ERASE


(Salmonella
enterica)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 ILE A  78
LEU A 106
VAL A  85
GLU A  74
LEU A  87
None
1.34A 2bxfB-1qapA:
undetectable
2bxfB-1qapA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE


(Lachancea
kluyveri)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 LEU A 440
ILE A 443
LEU A 134
VAL A 153
LEU A 137
None
1.27A 2bxfB-1r3nA:
undetectable
2bxfB-1r3nA:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
9 ILE A 388
ASN A 391
PHE A 403
TYR A 411
LEU A 430
VAL A 433
GLU A 450
LEU A 453
ARG A 485
None
0.87A 2bxfB-1tf0A:
47.4
2bxfB-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
6 LEU A 387
ILE A 388
ASN A 391
PHE A 403
GLU A 450
ARG A 485
None
0.93A 2bxfB-1tf0A:
47.4
2bxfB-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vaj HYPOTHETICAL PROTEIN
PH0010


(Pyrococcus
horikoshii)
PF01871
(AMMECR1)
5 PHE A 191
LEU A  13
VAL A 110
GLU A  43
LEU A  75
None
1.32A 2bxfB-1vajA:
undetectable
2bxfB-1vajA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woz 177AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(ST1454)


(Sulfurisphaera
tokodaii)
PF01923
(Cob_adeno_trans)
5 ILE A  77
PHE A  27
LEU A  34
GLU A  60
LEU A  61
None
1.34A 2bxfB-1wozA:
2.2
2bxfB-1wozA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxi DNA POLYMERASE III
SUBUNIT GAMMA


(Escherichia
coli)
PF12169
(DNA_pol3_gamma3)
PF13177
(DNA_pol3_delta2)
5 LEU B 218
LEU B 203
VAL B 232
GLU B 194
LEU B 191
None
1.25A 2bxfB-1xxiB:
3.5
2bxfB-1xxiB:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ysx SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
5 ILE A 388
ASN A 391
CYH A 392
PHE A 403
TYR A 411
4EB  A1000 ( 4.6A)
4EB  A1000 (-3.5A)
4EB  A1000 (-3.2A)
4EB  A1000 ( 4.1A)
4EB  A1000 (-3.3A)
0.81A 2bxfB-1ysxA:
4.8
2bxfB-1ysxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ysx SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
5 LEU A 387
ASN A 391
CYH A 392
PHE A 403
TYR A 411
None
4EB  A1000 (-3.5A)
4EB  A1000 (-3.2A)
4EB  A1000 ( 4.1A)
4EB  A1000 (-3.3A)
0.93A 2bxfB-1ysxA:
4.8
2bxfB-1ysxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT


(Homo sapiens)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
5 ILE A 367
ASN A 399
PHE A 401
TYR A 450
GLU A 396
None
1.10A 2bxfB-1z68A:
2.0
2bxfB-1z68A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zch HYPOTHETICAL
OXIDOREDUCTASE YCND


(Bacillus
subtilis)
PF00881
(Nitroreductase)
5 ILE A  49
LEU A  63
CYH A  80
LEU A 148
ARG A  56
None
1.28A 2bxfB-1zchA:
undetectable
2bxfB-1zchA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cd0 PROTEIN (BENCE-JONES
PROTEIN WIL, A
VARIABLE DOMAIN FROM
LAMBDA-6 TYPE
IMMUNOGLOBULIN LIGHT
CHAIN)


(Homo sapiens)
PF07686
(V-set)
5 TYR A  86
LEU A 104
VAL A 106
LEU A  78
ARG A  61
None
1.21A 2bxfB-2cd0A:
undetectable
2bxfB-2cd0A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus)
PF00491
(Arginase)
5 LEU A  75
VAL A 142
GLU A 153
LEU A 151
ARG A  71
None
1.23A 2bxfB-2ef4A:
undetectable
2bxfB-2ef4A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC


(Treponema
pallidum)
PF02608
(Bmp)
5 ASN A 125
LEU A 130
VAL A 293
GLU A 289
LEU A 288
None
1.31A 2bxfB-2fqxA:
undetectable
2bxfB-2fqxA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT


(Streptococcus
mutans)
PF04223
(CitF)
5 PHE A 274
VAL A 322
GLU A 319
LEU A 316
ARG A 292
None
1.18A 2bxfB-2hj0A:
undetectable
2bxfB-2hj0A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i88 COLICIN-E1

(Escherichia
coli)
PF01024
(Colicin)
5 ILE A 451
PHE A 393
LEU A 504
VAL A 500
LEU A 483
None
1.32A 2bxfB-2i88A:
2.1
2bxfB-2i88A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3m PROLYL-TRNA
SYNTHETASE


(Enterococcus
faecalis)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit)
5 ILE A 406
TYR A  40
VAL A  20
GLU A 218
ARG A 151
None
None
None
None
ATP  A 701 (-2.5A)
1.29A 2bxfB-2j3mA:
undetectable
2bxfB-2j3mA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8x URACIL-DNA
GLYCOSYLASE


(Human
gammaherpesvirus
4)
PF03167
(UDG)
5 LEU A 200
ILE A 201
LEU A 148
VAL A  86
LEU A  88
None
1.06A 2bxfB-2j8xA:
undetectable
2bxfB-2j8xA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM


(Homo sapiens)
PF00149
(Metallophos)
5 LEU C 170
ILE C 174
LEU C 158
VAL C  45
LEU C 177
None
1.22A 2bxfB-2nymC:
undetectable
2bxfB-2nymC:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p67 LAO/AO TRANSPORT
SYSTEM KINASE


(Escherichia
coli)
PF03308
(ArgK)
5 ILE A 246
LEU A 196
VAL A 198
GLU A 248
LEU A 236
None
1.30A 2bxfB-2p67A:
undetectable
2bxfB-2p67A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsr TRANSCRIPTION-REPAIR
COUPLING FACTOR


(Streptococcus
pneumoniae)
PF03461
(TRCF)
5 ILE A1160
PHE A1099
LEU A1080
VAL A1083
GLU A1159
None
1.09A 2bxfB-2qsrA:
undetectable
2bxfB-2qsrA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0o FCH DOMAIN ONLY
PROTEIN 2


(Homo sapiens)
PF00611
(FCH)
5 ILE A 227
LEU A  97
GLU A  46
LEU A  94
ARG A  42
None
1.22A 2bxfB-2v0oA:
3.5
2bxfB-2v0oA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT


(Escherichia
coli)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
5 LEU A  24
LEU A 145
GLU A  98
LEU A  99
ARG A  21
None
1.25A 2bxfB-2wu5A:
2.0
2bxfB-2wu5A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjt ATP-DEPENDENT RNA
HELICASE SRMB


(Escherichia
coli)
PF00271
(Helicase_C)
5 LEU D 232
LEU D 239
GLU D 263
LEU D 264
ARG D 260
None
1.31A 2bxfB-2yjtD:
undetectable
2bxfB-2yjtD:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE


(Thermus
thermophilus)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
5 LEU A 298
LEU A 242
VAL A 250
GLU A 199
LEU A 198
None
1.22A 2bxfB-2yzmA:
undetectable
2bxfB-2yzmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb0 4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE


(Brucella
melitensis)
PF01613
(Flavin_Reduct)
5 LEU A  60
ILE A  59
CYH A 131
VAL A  33
LEU A  46
None
None
None
None
FMN  A 200 (-3.8A)
1.12A 2bxfB-3cb0A:
undetectable
2bxfB-3cb0A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfi TYPE II SECRETORY
PATHWAY, PSEUDOPILIN
EPSJ


(Vibrio
vulnificus)
PF11612
(T2SSJ)
5 ASN B  86
LEU B 120
VAL B 145
GLU B 175
LEU B 176
None
1.25A 2bxfB-3cfiB:
undetectable
2bxfB-3cfiB:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 18 KDA
SUBUNIT


(Saccharomyces
cerevisiae)
PF04099
(Sybindin)
6 LEU C  51
TYR C  75
LEU C  91
VAL C  89
CYH C  81
LEU C  44
None
1.19A 2bxfB-3cueC:
undetectable
2bxfB-3cueC:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxm URACIL-DNA
GLYCOSYLASE


(Leishmania
naiffi)
PF03167
(UDG)
5 LEU A 318
ILE A 319
LEU A 264
VAL A 201
LEU A 203
None
1.11A 2bxfB-3cxmA:
undetectable
2bxfB-3cxmA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etc AMP-BINDING PROTEIN

(Methanosarcina
acetivorans)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 ILE A 494
LEU A 514
VAL A 518
GLU A 468
LEU A 471
None
1.04A 2bxfB-3etcA:
undetectable
2bxfB-3etcA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxh INTEGRON GENE
CASSETTE PROTEIN
HFX_CASS2


(uncultured
bacterium)
no annotation 5 LEU A  35
TYR A  49
LEU A  20
CYH A 103
LEU A  96
None
1.32A 2bxfB-3fxhA:
2.2
2bxfB-3fxhA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl0 MALEYLACETATE
REDUCTASE


(Agrobacterium
fabrum)
PF00465
(Fe-ADH)
5 ILE A  27
CYH A  88
LEU A  92
VAL A  37
LEU A  50
None
0.96A 2bxfB-3hl0A:
undetectable
2bxfB-3hl0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho6 TOXIN A

(Clostridioides
difficile)
PF11713
(Peptidase_C80)
5 ILE A  42
TYR A 171
LEU A 175
VAL A 153
GLU A 134
None
1.26A 2bxfB-3ho6A:
undetectable
2bxfB-3ho6A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE


(Bacillus
anthracis)
PF00342
(PGI)
5 LEU A 162
ILE A 158
LEU A 115
VAL A 117
LEU A 129
None
1.25A 2bxfB-3ifsA:
undetectable
2bxfB-3ifsA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqt SIGNAL TRANSDUCTION
HISTIDINE-PROTEIN
KINASE BARA


(Escherichia
coli)
PF01627
(Hpt)
5 LEU A 878
ILE A 882
LEU A 837
VAL A 840
LEU A 863
None
1.08A 2bxfB-3iqtA:
2.9
2bxfB-3iqtA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kds CELL DIVISION
PROTEIN FTSH


(Thermotoga
maritima)
PF00004
(AAA)
PF01434
(Peptidase_M41)
5 ILE E 301
LEU E 210
VAL E 214
GLU E 175
LEU E 173
None
0.92A 2bxfB-3kdsE:
2.4
2bxfB-3kdsE:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljf IRON SUPEROXIDE
DISMUTASE


(Pseudoalteromonas
haloplanktis)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
5 ILE A  11
TYR A  76
LEU A  80
GLU A  15
LEU A  14
None
1.31A 2bxfB-3ljfA:
undetectable
2bxfB-3ljfA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159


(Methanocaldococcus
jannaschii)
PF01995
(DUF128)
5 LEU A 410
VAL A 408
GLU A 470
LEU A 469
ARG A 466
None
1.34A 2bxfB-3nekA:
undetectable
2bxfB-3nekA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7b RIBOSOME BIOGENESIS
NEP1 RNA
METHYLTRANSFERASE


(Archaeoglobus
fulgidus)
PF03587
(EMG1)
5 LEU A 127
ILE A 128
ASN A  95
VAL A  82
LEU A  73
None
1.26A 2bxfB-3o7bA:
undetectable
2bxfB-3o7bA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
5 LEU A 348
ILE A 347
PHE A 580
TYR A 639
GLU A 302
None
1.34A 2bxfB-3ob8A:
undetectable
2bxfB-3ob8A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om8 PROBABLE HYDROLASE

(Pseudomonas
aeruginosa)
PF00561
(Abhydrolase_1)
5 LEU A  15
LEU A 100
VAL A 104
LEU A  77
ARG A  60
None
EDO  A 266 (-3.7A)
None
None
None
1.18A 2bxfB-3om8A:
undetectable
2bxfB-3om8A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE


(Corynebacterium
glutamicum)
PF00348
(polyprenyl_synt)
5 LEU A 286
LEU A 207
VAL A 211
LEU A 197
ARG A 282
None
1.30A 2bxfB-3qqvA:
2.4
2bxfB-3qqvA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlp PROTEIN POLYBROMO-1

(Homo sapiens)
PF00439
(Bromodomain)
5 LEU A 494
VAL A 498
CYH A 511
GLU A 583
LEU A 586
None
1.20A 2bxfB-3tlpA:
3.3
2bxfB-3tlpA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr7 URACIL-DNA
GLYCOSYLASE


(Coxiella
burnetii)
PF03167
(UDG)
5 LEU A 176
ILE A 177
LEU A 124
VAL A  62
LEU A  64
None
1.10A 2bxfB-3tr7A:
undetectable
2bxfB-3tr7A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR


(Caldanaerobacter
subterraneus)
PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF)
5 LEU A 684
ILE A 688
LEU A 699
VAL A 697
LEU A 717
None
1.32A 2bxfB-3vthA:
undetectable
2bxfB-3vthA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdg URACIL-DNA
GLYCOSYLASE


(Staphylococcus
aureus)
PF03167
(UDG)
5 LEU A 167
ILE A 168
LEU A 115
VAL A  54
LEU A  56
None
1.05A 2bxfB-3wdgA:
undetectable
2bxfB-3wdgA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1o ROQUIN-1

(Homo sapiens)
no annotation 5 LEU A 307
LEU A 249
VAL A 245
LEU A 204
ARG A 280
None
1.34A 2bxfB-3x1oA:
undetectable
2bxfB-3x1oA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buh CLONE M0418 SCFV

(Homo sapiens)
PF07686
(V-set)
5 TYR A 228
LEU A 248
VAL A 250
LEU A 220
ARG A 203
None
1.33A 2bxfB-4buhA:
undetectable
2bxfB-4buhA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cad RAS AND A-FACTOR
CONVERTING ENZYME 1,
RCE1


(Methanococcus
maripaludis)
PF02517
(Abi)
5 LEU C 229
ILE C 230
ASN C 233
VAL C  96
LEU C  92
None
None
BOG  C 301 (-3.0A)
None
None
1.32A 2bxfB-4cadC:
2.8
2bxfB-4cadC:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ILE A 780
CYH A 772
LEU A 839
VAL A 836
LEU A 743
None
1.27A 2bxfB-4ckrA:
undetectable
2bxfB-4ckrA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2u PHO RADA INTEIN

(Pyrococcus
horikoshii)
PF14890
(Intein_splicing)
5 LEU A  76
ILE A  77
LEU A 170
VAL A  95
LEU A  87
None
1.02A 2bxfB-4e2uA:
undetectable
2bxfB-4e2uA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx0 TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens)
PF02080
(TrkA_C)
PF02254
(TrkA_N)
PF07885
(Ion_trans_2)
5 PHE A 136
VAL A 178
GLU A 124
LEU A 125
ARG A 192
None
1.29A 2bxfB-4gx0A:
3.1
2bxfB-4gx0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh1 APPA PROTEIN

(Rhodobacter
sphaeroides)
PF04940
(BLUF)
5 LEU A  91
ILE A  90
CYH A  19
GLU A  89
ARG A  22
None
1.22A 2bxfB-4hh1A:
undetectable
2bxfB-4hh1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqh DYSFERLIN

(Homo sapiens)
PF00168
(C2)
5 LEU A  94
PHE A 103
LEU A  67
VAL A 123
LEU A   3
None
1.34A 2bxfB-4iqhA:
undetectable
2bxfB-4iqhA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED


(Xanthomonas
oryzae)
PF01053
(Cys_Met_Meta_PP)
5 LEU B 118
PHE B 133
VAL B 105
LEU B 129
ARG B 123
None
1.33A 2bxfB-4iyoB:
undetectable
2bxfB-4iyoB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jip GTN REDUCTASE

(Agrobacterium
tumefaciens)
PF00724
(Oxidored_FMN)
5 ILE A 229
PHE A 289
LEU A 248
VAL A 252
LEU A 189
None
1.26A 2bxfB-4jipA:
undetectable
2bxfB-4jipA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq8 CYTOCHROME P450 19A1

(Homo sapiens)
PF00067
(p450)
5 ILE A 132
ASN A 135
LEU A 122
CYH A 299
ARG A 115
HEM  A 601 (-3.8A)
None
None
None
HEM  A 601 ( 2.6A)
1.31A 2bxfB-4kq8A:
undetectable
2bxfB-4kq8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4z SRC-LIKE-ADAPTER 2

(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
5 LEU A 110
ASN A 113
TYR A  96
LEU A 119
GLU A 106
None
1.33A 2bxfB-4m4zA:
undetectable
2bxfB-4m4zA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE


(Thermomonospora
curvata)
PF01580
(FtsK_SpoIIIE)
5 LEU A 944
ASN A 942
VAL A 940
GLU A 954
ARG A 947
None
1.31A 2bxfB-4n1aA:
undetectable
2bxfB-4n1aA:
21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
9 LEU A 387
ASN A 391
PHE A 403
TYR A 411
LEU A 430
VAL A 433
GLU A 450
LEU A 453
ARG A 485
NPS  A 601 ( 4.7A)
NPS  A 601 (-4.3A)
None
NPS  A 601 (-4.3A)
NPS  A 601 ( 4.0A)
None
None
NPS  A 601 (-4.7A)
None
0.68A 2bxfB-4po0A:
49.5
2bxfB-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qik ROQUIN-1

(Homo sapiens)
no annotation 5 LEU A 307
LEU A 249
VAL A 245
LEU A 204
ARG A 280
None
1.33A 2bxfB-4qikA:
2.5
2bxfB-4qikA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qus ACETYLTRANSFERASE
YPEA


(Escherichia
coli)
PF00583
(Acetyltransf_1)
5 ILE A 105
LEU A  44
VAL A  58
GLU A  92
LEU A  91
None
1.34A 2bxfB-4qusA:
undetectable
2bxfB-4qusA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5q CRISPR-ASSOCIATED
EXONUCLEASE, CAS4
FAMILY


(Pyrobaculum
calidifontis)
PF01930
(Cas_Cas4)
5 ILE A 133
TYR A  97
LEU A 101
VAL A 107
LEU A   3
None
1.18A 2bxfB-4r5qA:
undetectable
2bxfB-4r5qA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z31 ROQUIN-2

(Homo sapiens)
no annotation 5 LEU A 304
LEU A 246
VAL A 242
LEU A 201
ARG A 277
None
1.32A 2bxfB-4z31A:
2.7
2bxfB-4z31A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlc ROQUIN-2

(Homo sapiens)
no annotation 5 LEU A 304
LEU A 246
VAL A 242
LEU A 201
ARG A 277
None
1.29A 2bxfB-4zlcA:
2.2
2bxfB-4zlcA:
13.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
8 ASN A 390
PHE A 402
TYR A 410
LEU A 429
VAL A 432
GLU A 449
LEU A 452
ARG A 484
None
0.78A 2bxfB-5dqfA:
50.1
2bxfB-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
7 LEU A 386
ASN A 390
PHE A 402
TYR A 410
VAL A 432
GLU A 449
ARG A 484
None
0.73A 2bxfB-5dqfA:
50.1
2bxfB-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))


(Clostridioides
difficile)
PF08501
(Shikimate_dh_N)
5 LEU A 164
ILE A 163
LEU A 124
VAL A 122
GLU A 169
None
1.23A 2bxfB-5dzsA:
undetectable
2bxfB-5dzsA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5f ROQUIN-1

(Mus musculus)
no annotation 5 LEU A 307
LEU A 249
VAL A 245
LEU A 204
ARG A 280
None
1.29A 2bxfB-5f5fA:
undetectable
2bxfB-5f5fA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbu PHOSPHOENOLPYRUVATE
SYNTHASE


(Listeria
monocytogenes)
PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
5 LEU A 604
ILE A 605
ASN A 608
TYR A 833
LEU A 528
None
1.08A 2bxfB-5fbuA:
3.1
2bxfB-5fbuA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwj HISTONE DEMETHYLASE
JARID1C


(Homo sapiens)
PF02373
(JmjC)
PF02375
(JmjN)
PF02928
(zf-C5HC2)
5 ILE A 515
LEU A 576
VAL A 537
GLU A 546
LEU A 545
None
1.21A 2bxfB-5fwjA:
undetectable
2bxfB-5fwjA:
20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
8 ASN A 391
PHE A 403
TYR A 411
LEU A 430
VAL A 433
GLU A 450
LEU A 453
ARG A 485
None
0.76A 2bxfB-5ghkA:
46.6
2bxfB-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
6 LEU A 387
ASN A 391
TYR A 411
VAL A 433
GLU A 450
ARG A 485
None
0.95A 2bxfB-5ghkA:
46.6
2bxfB-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus)
no annotation 5 ILE C 321
ASN C 368
LEU C 426
GLU C 376
ARG C 375
None
SFG  C1002 (-4.1A)
None
None
None
1.29A 2bxfB-5hr4C:
undetectable
2bxfB-5hr4C:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk6 PHENYLALANINE-4-HYDR
OXYLASE


(Dictyostelium
discoideum)
PF00351
(Biopterin_H)
5 LEU A 412
ILE A 411
LEU A 296
GLU A 410
ARG A 401
None
1.13A 2bxfB-5jk6A:
undetectable
2bxfB-5jk6A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN


(Trichodesmium
erythraeum)
no annotation 5 LEU A  49
ASN A  32
PHE A 240
GLU A  40
LEU A  39
None
1.30A 2bxfB-5jvbA:
undetectable
2bxfB-5jvbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbc DSBA

(Chlamydia
trachomatis)
PF13462
(Thioredoxin_4)
5 LEU A 155
ASN A 158
TYR A  98
LEU A  66
GLU A  35
None
1.10A 2bxfB-5kbcA:
undetectable
2bxfB-5kbcA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1t PENTALENOLACTONE
SYNTHASE


(Streptomyces
arenae)
PF00067
(p450)
5 LEU A 247
ILE A 272
PHE A 365
GLU A 271
LEU A 329
None
1.30A 2bxfB-5l1tA:
undetectable
2bxfB-5l1tA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2x DNA-DIRECTED
PRIMASE/POLYMERASE
PROTEIN


(Homo sapiens)
no annotation 5 LEU A 134
ILE A 135
CYH A 139
TYR A 284
CYH A 150
None
0.83A 2bxfB-5l2xA:
undetectable
2bxfB-5l2xA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae)
PF13691
(Lactamase_B_4)
5 LEU A 718
ILE A 756
PHE A 692
VAL A 489
LEU A 507
None
1.15A 2bxfB-5mtzA:
undetectable
2bxfB-5mtzA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn7 URACIL-DNA
GLYCOSYLASE


(Human
gammaherpesvirus
8)
no annotation 5 LEU A 197
ILE A 198
LEU A 145
VAL A  83
LEU A  85
None
1.07A 2bxfB-5nn7A:
undetectable
2bxfB-5nn7A:
9.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 9 ILE A 387
ASN A 390
PHE A 402
TYR A 410
LEU A 429
VAL A 432
GLU A 449
LEU A 452
ARG A 484
None
0.88A 2bxfB-5oriA:
49.4
2bxfB-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 7 LEU A 386
ILE A 387
TYR A 410
VAL A 432
GLU A 449
LEU A 452
ARG A 484
None
1.14A 2bxfB-5oriA:
49.4
2bxfB-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uic TWO-COMPONENT
RESPONSE REGULATOR


(Francisella
tularensis)
PF00072
(Response_reg)
5 LEU A 105
LEU A  29
VAL A  27
GLU A  18
LEU A  17
None
1.30A 2bxfB-5uicA:
undetectable
2bxfB-5uicA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A


(Homo sapiens)
PF00628
(PHD)
PF01388
(ARID)
PF02373
(JmjC)
PF02375
(JmjN)
PF02928
(zf-C5HC2)
PF08429
(PLU-1)
5 ILE A 484
LEU A 545
VAL A 506
GLU A 515
LEU A 514
None
1.12A 2bxfB-5v9pA:
undetectable
2bxfB-5v9pA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8p HOMOSERINE
O-ACETYLTRANSFERASE


(Mycobacteroides
abscessus)
PF00561
(Abhydrolase_1)
5 LEU A 183
VAL A 320
CYH A 345
GLU A 369
LEU A 370
None
1.23A 2bxfB-5w8pA:
undetectable
2bxfB-5w8pA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT


(Komagataella
phaffii)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
5 LEU A1023
TYR A 898
VAL A 992
CYH A 996
ARG A1027
None
1.27A 2bxfB-5xogA:
2.4
2bxfB-5xogA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqw FAB FRAGMENT OF
CATALYTIC ANTIBODY
7B9, LIGHT CHAIN


(Mus musculus)
no annotation 5 TYR L  86
LEU L 104
GLU L  79
LEU L  78
ARG L  61
None
1.27A 2bxfB-5xqwL:
undetectable
2bxfB-5xqwL:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yax SCFV1 ANTIBODY

(Homo sapiens)
no annotation 5 TYR A1102
LEU A1124
VAL A1126
LEU A1094
ARG A1075
None
1.18A 2bxfB-5yaxA:
undetectable
2bxfB-5yaxA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE


(Bacillus
alcalophilus)
no annotation 5 ILE A 307
VAL A 241
GLU A 287
LEU A 290
ARG A 300
None
1.32A 2bxfB-5yo8A:
2.4
2bxfB-5yo8A:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 8 ASN A 391
PHE A 403
TYR A 411
LEU A 430
VAL A 433
GLU A 450
LEU A 453
ARG A 485
None
0.90A 2bxfB-5yxeA:
47.3
2bxfB-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 8 LEU A 387
ASN A 391
PHE A 403
TYR A 411
VAL A 433
GLU A 450
LEU A 453
ARG A 485
None
0.96A 2bxfB-5yxeA:
47.3
2bxfB-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN


(Homo sapiens)
no annotation 5 ILE A 484
LEU A 545
VAL A 506
GLU A 515
LEU A 514
None
1.26A 2bxfB-6bgzA:
undetectable
2bxfB-6bgzA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B


(Homo sapiens)
no annotation 5 ILE A 500
LEU A 561
VAL A 522
GLU A 531
LEU A 530
DMS  A 805 (-4.9A)
None
None
DMS  A 805 ( 4.6A)
None
1.30A 2bxfB-6ek6A:
undetectable
2bxfB-6ek6A:
7.86