SIMILAR PATTERNS OF AMINO ACIDS FOR 2BXF_A_DZPA2001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		5 ILE A 294
ASN A 338
LEU A 411
VAL A 375
LEU A 365
 None
 1.20A 2bxfA-1b1yA:
undetectable		 2bxfA-1b1yA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6b SAR1

(Cricetulus
griseus) 		PF00025
(Arf) 		5 LEU A 115
VAL A 100
GLU A 144
LEU A 147
ARG A 148
 None
None
None
None
SO4  A 405 (-3.2A)
 1.25A 2bxfA-1f6bA:
undetectable		 2bxfA-1f6bA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE

(Arabidopsis
thaliana) 		PF16363
(GDP_Man_Dehyd) 		5 ILE A  70
LEU A  84
VAL A  55
GLU A  46
LEU A  49
 None
 1.04A 2bxfA-1n7gA:
undetectable		 2bxfA-1n7gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844

(Thermotoga
maritima) 		PF02590
(SPOUT_MTase) 		5 ILE A   5
PHE A  81
LEU A  85
GLU A  23
LEU A  26
 None
 1.18A 2bxfA-1o6dA:
undetectable		 2bxfA-1o6dA:
14.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		10 ILE A 388
ASN A 391
PHE A 403
LEU A 407
TYR A 411
LEU A 430
VAL A 433
GLU A 450
LEU A 453
ARG A 485
 None
 0.85A 2bxfA-1tf0A:
47.1		 2bxfA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 ILE A 350
LEU A 375
LEU A 332
GLU A 354
LEU A 328
 None
 1.15A 2bxfA-1v8bA:
undetectable		 2bxfA-1v8bA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00218
(IGPS) 		5 PHE A 230
LEU A 211
LEU A 178
GLU A 164
LEU A 167
 None
 1.23A 2bxfA-1vc4A:
undetectable		 2bxfA-1vc4A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN

(Thermus
thermophilus) 		PF10432
(bact-PGI_C) 		5 LEU A 166
LEU A 216
GLU A 207
LEU A 206
ARG A 237
 None
 1.24A 2bxfA-1wiwA:
undetectable		 2bxfA-1wiwA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxi DNA POLYMERASE III
SUBUNIT GAMMA

(Escherichia
coli) 		PF12169
(DNA_pol3_gamma3)
PF13177
(DNA_pol3_delta2) 		5 LEU B 206
LEU B 203
VAL B 232
GLU B 194
LEU B 191
 None
 1.17A 2bxfA-1xxiB:
3.2		 2bxfA-1xxiB:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ysx SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 ILE A 388
ASN A 391
CYH A 392
PHE A 403
LEU A 407
TYR A 411
 4EB  A1000 ( 4.6A)
4EB  A1000 (-3.5A)
4EB  A1000 (-3.2A)
4EB  A1000 ( 4.1A)
4EB  A1000 (-4.5A)
4EB  A1000 (-3.3A)
 1.03A 2bxfA-1ysxA:
12.8		 2bxfA-1ysxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 ILE A 367
ASN A 399
PHE A 401
TYR A 450
GLU A 396
 None
 1.05A 2bxfA-1z68A:
undetectable		 2bxfA-1z68A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 LEU A 177
LEU A  75
GLU A  28
LEU A  31
ARG A 189
 None
 1.25A 2bxfA-2akpA:
undetectable		 2bxfA-2akpA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c91 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2

(Mus musculus) 		PF00248
(Aldo_ket_red) 		5 LEU A 288
LEU A 291
GLU A 299
LEU A 295
ARG A  34
 None
 1.14A 2bxfA-2c91A:
undetectable		 2bxfA-2c91A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cai GLUTATHIONE
S-TRANSFERASE 28 KDA

(Schistosoma
haematobium) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 178
TYR A 182
VAL A 166
GLU A 108
LEU A 105
 None
 1.13A 2bxfA-2caiA:
2.7		 2bxfA-2caiA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		5 ILE A 411
LEU A 384
LEU A 344
VAL A 414
GLU A 407
 None
 1.17A 2bxfA-2cdqA:
2.0		 2bxfA-2cdqA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 LEU A 230
TYR A 224
LEU A 228
VAL A  89
LEU A  85
 None
 1.14A 2bxfA-2dieA:
undetectable		 2bxfA-2dieA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fli RIBULOSE-PHOSPHATE
3-EPIMERASE

(Streptococcus
pyogenes) 		PF00834
(Ribul_P_3_epim) 		5 ILE A 137
PHE A 171
LEU A 129
LEU A 128
VAL A 114
 None
 1.20A 2bxfA-2fliA:
undetectable		 2bxfA-2fliA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsz TWITCHING MOTILITY
PROTEIN PILT

(Aquifex
aeolicus) 		PF00437
(T2SSE) 		5 ILE A 139
LEU A 122
LEU A 124
VAL A 128
CYH A 132
 None
 1.21A 2bxfA-2gszA:
undetectable		 2bxfA-2gszA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2haw MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Bacillus
subtilis) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 PHE A 250
LEU A 252
LEU A 234
VAL A 237
GLU A 198
 None
 1.20A 2bxfA-2hawA:
undetectable		 2bxfA-2hawA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hbw NLP/P60 PROTEIN

(Trichormus
variabilis) 		PF00877
(NLPC_P60) 		5 CYH A  60
LEU A  25
LEU A  68
VAL A  46
LEU A  76
 None
 1.08A 2bxfA-2hbwA:
undetectable		 2bxfA-2hbwA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		5 PHE A 274
VAL A 322
GLU A 319
LEU A 316
ARG A 292
 None
 1.13A 2bxfA-2hj0A:
undetectable		 2bxfA-2hj0A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i54 PHOSPHOMANNOMUTASE

(Leishmania
mexicana) 		PF03332
(PMM) 		5 PHE A  63
LEU A  40
LEU A   7
GLU A 240
LEU A 239
 None
 1.20A 2bxfA-2i54A:
undetectable		 2bxfA-2i54A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		5 ILE A 310
LEU A 342
TYR A 346
VAL A 482
GLU A 495
 None
 1.23A 2bxfA-2jgpA:
undetectable		 2bxfA-2jgpA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnn PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF01047
(MarR) 		5 ILE A  69
ASN A  56
LEU A  94
VAL A  96
GLU A  74
 None
 1.06A 2bxfA-2nnnA:
undetectable		 2bxfA-2nnnA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plj LYSINE/ORNITHINE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A 191
LEU A 230
VAL A 265
LEU A 261
ARG A 213
 None
 1.16A 2bxfA-2pljA:
undetectable		 2bxfA-2pljA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsr TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Streptococcus
pneumoniae) 		PF03461
(TRCF) 		5 ILE A1160
PHE A1099
LEU A1080
VAL A1083
GLU A1159
 None
 1.07A 2bxfA-2qsrA:
undetectable		 2bxfA-2qsrA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE

(Lactobacillus
plantarum) 		PF03807
(F420_oxidored) 		5 ILE A  70
PHE A 141
LEU A 145
LEU A 150
LEU A 115
 NAP  A 200 ( 4.3A)
None
None
None
None
 1.21A 2bxfA-2rafA:
undetectable		 2bxfA-2rafA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0o FCH DOMAIN ONLY
PROTEIN 2

(Homo sapiens) 		PF00611
(FCH) 		5 ILE A 227
LEU A  97
GLU A  46
LEU A  94
ARG A  42
 None
 1.22A 2bxfA-2v0oA:
3.0		 2bxfA-2v0oA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		5 PHE A 217
LEU A 215
LEU A 109
VAL A 141
LEU A 122
 None
 1.23A 2bxfA-2vmfA:
undetectable		 2bxfA-2vmfA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0e UDP-GLUCOSE
DEHYDROGENASE

(Burkholderia
cepacia) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 PHE A  81
LEU A   3
VAL A 115
GLU A 186
LEU A 187
 None
None
None
SO4  A1462 ( 4.8A)
None
 1.15A 2bxfA-2y0eA:
undetectable		 2bxfA-2y0eA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		5 ILE C  64
LEU C 112
LEU C  99
CYH C  42
LEU C  35
 None
None
None
SF4  C1413 (-2.3A)
None
 1.15A 2bxfA-2ynmC:
undetectable		 2bxfA-2ynmC:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		no annotation 5 ILE E 164
LEU E  50
LEU E  48
LEU E 139
ARG E  66
 None
 1.17A 2bxfA-3aoeE:
undetectable		 2bxfA-3aoeE:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfi TYPE II SECRETORY
PATHWAY, PSEUDOPILIN
EPSJ

(Vibrio
vulnificus) 		PF11612
(T2SSJ) 		5 ASN B  86
LEU B 120
VAL B 145
GLU B 175
LEU B 176
 None
 1.23A 2bxfA-3cfiB:
undetectable		 2bxfA-3cfiB:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 18 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF04099
(Sybindin) 		5 TYR C  75
LEU C  91
VAL C  89
CYH C  81
LEU C  44
 None
 1.19A 2bxfA-3cueC:
undetectable		 2bxfA-3cueC:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwv DNA GYRASE, B
SUBUNIT, TRUNCATED

(Myxococcus
xanthus) 		PF00204
(DNA_gyraseB) 		5 LEU A  65
LEU A  55
VAL A 189
GLU A 179
ARG A 176
 None
 0.90A 2bxfA-3cwvA:
undetectable		 2bxfA-3cwvA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9h CDNA FLJ77766,
HIGHLY SIMILAR TO
HOMO SAPIENS ANKYRIN
REPEAT AND SOCS
BOX-CONTAINING 9
(ASB9), TRANSCRIPT
VARIANT 2, MRNA

(Homo sapiens) 		PF12796
(Ank_2) 		5 LEU A 171
VAL A 206
GLU A 213
LEU A 214
ARG A 180
 None
 1.23A 2bxfA-3d9hA:
undetectable		 2bxfA-3d9hA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE

(Bacillus cereus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 PHE A 268
LEU A 273
LEU A 319
LEU A 313
ARG A 279
 None
 1.23A 2bxfA-3dhvA:
undetectable		 2bxfA-3dhvA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		5 ILE A  55
LEU A  63
LEU A  69
VAL A  82
LEU A  93
 None
 1.25A 2bxfA-3e3xA:
undetectable		 2bxfA-3e3xA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etc AMP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ILE A 494
LEU A 514
VAL A 518
GLU A 468
LEU A 471
 None
 1.04A 2bxfA-3etcA:
undetectable		 2bxfA-3etcA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl0 MALEYLACETATE
REDUCTASE

(Agrobacterium
fabrum) 		PF00465
(Fe-ADH) 		5 ILE A  27
CYH A  88
LEU A  92
VAL A  37
LEU A  50
 None
 0.95A 2bxfA-3hl0A:
undetectable		 2bxfA-3hl0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyj PROTEIN DUF199/WHIA

(Thermotoga
maritima) 		PF10298
(WhiA_N)
PF14527
(LAGLIDADG_WhiA) 		5 PHE A 114
LEU A 118
GLU A 141
LEU A 144
ARG A 168
 None
 1.16A 2bxfA-3hyjA:
undetectable		 2bxfA-3hyjA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixr BACTERIOFERRITIN
COMIGRATORY PROTEIN

(Xylella
fastidiosa) 		PF00578
(AhpC-TSA) 		6 CYH A 101
PHE A  38
LEU A  36
LEU A  69
VAL A  93
LEU A  16
 None
 1.38A 2bxfA-3ixrA:
undetectable		 2bxfA-3ixrA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixr BACTERIOFERRITIN
COMIGRATORY PROTEIN

(Xylella
fastidiosa) 		PF00578
(AhpC-TSA) 		5 ILE A  99
PHE A  38
LEU A  36
LEU A  69
LEU A  16
 None
 0.93A 2bxfA-3ixrA:
undetectable		 2bxfA-3ixrA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kds CELL DIVISION
PROTEIN FTSH

(Thermotoga
maritima) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		5 ILE E 301
LEU E 210
VAL E 214
GLU E 175
LEU E 173
 None
 0.89A 2bxfA-3kdsE:
undetectable		 2bxfA-3kdsE:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lb6 INTERLEUKIN-13
RECEPTOR SUBUNIT
ALPHA-2

(Homo sapiens) 		PF09240
(IL6Ra-bind) 		5 PHE D 246
LEU D 256
TYR D 293
LEU D 295
LEU D 283
 None
 1.23A 2bxfA-3lb6D:
undetectable		 2bxfA-3lb6D:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		5 LEU A 806
TYR A 810
VAL A 780
CYH A 784
LEU A 834
 None
 1.25A 2bxfA-3m62A:
undetectable		 2bxfA-3m62A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus) 		PF00079
(Serpin) 		5 LEU A 236
LEU A 357
VAL A 371
LEU A  19
ARG A  20
 None
 1.07A 2bxfA-3ndaA:
undetectable		 2bxfA-3ndaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niv GLUTATHIONE
S-TRANSFERASE

(Legionella
pneumophila) 		PF13417
(GST_N_3) 		5 ILE A 170
PHE A 140
LEU A 136
TYR A 132
VAL A 101
 None
 1.10A 2bxfA-3nivA:
2.5		 2bxfA-3nivA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7b RIBOSOME BIOGENESIS
NEP1 RNA
METHYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF03587
(EMG1) 		5 ILE A 138
LEU A 146
VAL A 144
GLU A 183
LEU A 184
 None
 1.14A 2bxfA-3o7bA:
undetectable		 2bxfA-3o7bA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS

(Aspergillus
oryzae) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 185
LEU A 197
GLU A 355
LEU A 356
ARG A 171
 None
 1.08A 2bxfA-3q9tA:
undetectable		 2bxfA-3q9tA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvm OLEI00960

(Oleispira
antarctica) 		PF00561
(Abhydrolase_1) 		5 CYH A  38
PHE A 189
LEU A 168
LEU A 171
LEU A 230
 None
 1.22A 2bxfA-3qvmA:
undetectable		 2bxfA-3qvmA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6i DNA-3-METHYLADENINE
GLYCOSYLASE 1

(Schizosaccharomyces
pombe) 		PF00730
(HhH-GPD) 		5 LEU A  54
LEU A 155
GLU A 136
LEU A 137
ARG A 140
 None
 1.21A 2bxfA-3s6iA:
undetectable		 2bxfA-3s6iA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0q AGR253WP

(Eremothecium
gossypii) 		PF00225
(Kinesin) 		5 ASN A 366
TYR A 370
LEU A 676
VAL A 447
LEU A 437
 None
 1.25A 2bxfA-3t0qA:
undetectable		 2bxfA-3t0qA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tox SHORT CHAIN
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ILE A 132
PHE A 142
LEU A 169
VAL A 184
LEU A 177
 None
 1.17A 2bxfA-3toxA:
undetectable		 2bxfA-3toxA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00342
(PGI) 		5 LEU A  65
LEU A 327
VAL A 330
LEU A 504
ARG A  72
 None
 1.23A 2bxfA-3ujhA:
undetectable		 2bxfA-3ujhA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um9 HALOACID
DEHALOGENASE, TYPE
II

(Polaromonas sp.
JS666) 		PF13419
(HAD_2) 		5 ILE A 194
LEU A 107
LEU A 104
VAL A 100
LEU A  15
 None
 1.23A 2bxfA-3um9A:
undetectable		 2bxfA-3um9A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aod ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 1

(Biomphalaria
glabrata) 		PF02931
(Neur_chan_LBD) 		5 ILE A  91
PHE A  33
LEU A  58
TYR A 116
LEU A 120
 None
 0.93A 2bxfA-4aodA:
undetectable		 2bxfA-4aodA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE

(Brevibacillus
brevis) 		PF03306
(AAL_decarboxy) 		5 PHE A 213
LEU A 135
LEU A 218
GLU A 121
LEU A 120
 None
 1.14A 2bxfA-4bt6A:
undetectable		 2bxfA-4bt6A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		5 CYH B 328
LEU B 424
LEU B 419
CYH B 396
LEU B 370
 ZN  B1428 (-2.2A)
None
None
ZN  B1428 (-2.2A)
None
 1.24A 2bxfA-4ci2B:
2.1		 2bxfA-4ci2B:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7a TRNA
THREONYLCARBAMOYLADE
NOSINE DEHYDRATASE

(Escherichia
coli) 		PF00899
(ThiF) 		5 ILE A  93
ASN A  97
CYH A 100
GLU A  47
ARG A  51
 None
 1.15A 2bxfA-4d7aA:
undetectable		 2bxfA-4d7aA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 ILE A 222
LEU A 121
VAL A 150
GLU A 220
ARG A 189
 None
 1.22A 2bxfA-4g56A:
undetectable		 2bxfA-4g56A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gjh TNF
RECEPTOR-ASSOCIATED
FACTOR 5

(Mus musculus) 		no annotation 5 LEU A 494
LEU A 434
VAL A 474
GLU A 480
LEU A 479
 None
 1.12A 2bxfA-4gjhA:
undetectable		 2bxfA-4gjhA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ict CYTOCHROME P450 121

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 LEU A 284
VAL A 307
GLU A  56
LEU A  55
ARG A 340
 HEM  A 405 (-3.5A)
None
None
None
None
 1.24A 2bxfA-4ictA:
undetectable		 2bxfA-4ictA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilg A1 CISTRON-SPLICING
FACTOR AAR2

(Saccharomyces
cerevisiae) 		PF05282
(AAR2) 		5 ILE A 247
CYH A 292
LEU A 317
LEU A 316
LEU A 284
 None
 1.16A 2bxfA-4ilgA:
undetectable		 2bxfA-4ilgA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		5 LEU A 364
LEU A 338
VAL A 369
LEU A 372
ARG A 283
 None
 1.21A 2bxfA-4knaA:
undetectable		 2bxfA-4knaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kuj PROTEIN KINASE,
PUTATIVE

(Entamoeba
histolytica) 		PF02816
(Alpha_kinase) 		5 ILE A  46
PHE A 234
LEU A 226
LEU A 205
LEU A  40
 None
 1.23A 2bxfA-4kujA:
undetectable		 2bxfA-4kujA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp4 GLUTATHIONE
S-TRANSFERASE

(Acinetobacter
baumannii) 		PF13417
(GST_N_3)
PF14834
(GST_C_4) 		5 ILE A 164
LEU A   9
LEU A  63
GLU A  81
LEU A  80
 None
 1.03A 2bxfA-4mp4A:
2.5		 2bxfA-4mp4A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ

(Pseudomonas
putida) 		PF16822
(ALGX) 		5 PHE A 332
LEU A 327
VAL A 340
LEU A 126
ARG A 116
 None
 1.16A 2bxfA-4o8vA:
undetectable		 2bxfA-4o8vA:
18.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		9 ASN A 391
PHE A 403
LEU A 407
TYR A 411
LEU A 430
VAL A 433
GLU A 450
LEU A 453
ARG A 485
 NPS  A 601 (-4.3A)
None
NPS  A 601 ( 4.9A)
NPS  A 601 (-4.3A)
NPS  A 601 ( 4.0A)
None
None
NPS  A 601 (-4.7A)
None
 0.59A 2bxfA-4po0A:
45.8		 2bxfA-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py5 RIBONUCLEASE

(Thermovibrio
ammonificans) 		PF01351
(RNase_HII) 		6 LEU A 138
TYR A 143
LEU A  89
VAL A  91
GLU A 158
LEU A 157
 None
None
None
None
SO4  A 306 ( 4.8A)
None
 1.34A 2bxfA-4py5A:
undetectable		 2bxfA-4py5A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdv M7GPPPX
DIPHOSPHATASE

(Homo sapiens) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		5 ILE A 244
TYR A 312
LEU A 230
CYH A 222
LEU A 267
 None
PO4  A 403 (-4.5A)
None
None
None
 1.20A 2bxfA-4qdvA:
undetectable		 2bxfA-4qdvA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5q CRISPR-ASSOCIATED
EXONUCLEASE, CAS4
FAMILY

(Pyrobaculum
calidifontis) 		PF01930
(Cas_Cas4) 		5 ILE A 133
TYR A  97
LEU A 101
VAL A 107
LEU A   3
 None
 1.19A 2bxfA-4r5qA:
undetectable		 2bxfA-4r5qA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xac EVDO2

(Micromonospora
carbonacea) 		PF05721
(PhyH) 		5 ILE A  75
LEU A 150
LEU A  38
GLU A  79
LEU A  85
 None
 1.04A 2bxfA-4xacA:
undetectable		 2bxfA-4xacA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt0 PROTEIN LIGF

(Sphingobium sp.
SYK-6) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ILE A 194
LEU A   4
LEU A  56
GLU A  74
LEU A  73
 None
 1.09A 2bxfA-4xt0A:
undetectable		 2bxfA-4xt0A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		5 LEU A 543
LEU A 546
VAL A 321
LEU A 562
ARG A 323
 None
 1.22A 2bxfA-5cslA:
undetectable		 2bxfA-5cslA:
14.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		9 ASN A 390
PHE A 402
LEU A 406
TYR A 410
LEU A 429
VAL A 432
GLU A 449
LEU A 452
ARG A 484
 None
 0.69A 2bxfA-5dqfA:
46.5		 2bxfA-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEOSOME SUBUNIT
ALPHA TYPE 1,
PUTATIVE

(Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ILE F  70
CYH F  92
LEU F  84
VAL F 112
LEU F 132
 None
 1.20A 2bxfA-5fmgF:
undetectable		 2bxfA-5fmgF:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1

(Homo sapiens) 		no annotation 5 LEU A 121
LEU A  98
VAL A  65
CYH A  63
LEU A  24
 None
 1.00A 2bxfA-5forA:
undetectable		 2bxfA-5forA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1

(Thielavia
terrestris) 		PF05183
(RdRP) 		5 LEU A 603
LEU A 606
VAL A 542
LEU A 367
ARG A 333
 None
 1.08A 2bxfA-5fswA:
1.1		 2bxfA-5fswA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwj HISTONE DEMETHYLASE
JARID1C

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN)
PF02928
(zf-C5HC2) 		5 ILE A 515
LEU A 576
VAL A 537
GLU A 546
LEU A 545
 None
 1.21A 2bxfA-5fwjA:
undetectable		 2bxfA-5fwjA:
20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		9 ASN A 391
PHE A 403
LEU A 407
TYR A 411
LEU A 430
VAL A 433
GLU A 450
LEU A 453
ARG A 485
 None
 0.68A 2bxfA-5ghkA:
45.2		 2bxfA-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3a ORF70

(Human
gammaherpesvirus
8) 		PF00303
(Thymidylat_synt) 		5 PHE A 320
LEU A 256
LEU A 112
GLU A 313
LEU A 116
 None
 1.19A 2bxfA-5h3aA:
undetectable		 2bxfA-5h3aA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		5 LEU A 499
LEU A 469
VAL A 505
GLU A 479
LEU A 478
 None
 1.20A 2bxfA-5hzwA:
undetectable		 2bxfA-5hzwA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la7 HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		5 PHE A 386
LEU A  65
LEU A  72
GLU A 113
ARG A  70
 None
 1.16A 2bxfA-5la7A:
undetectable		 2bxfA-5la7A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdj HOXK
UPTAKE HYDROGENASE
SMALL SUBUNIT

(Cupriavidus
necator) 		no annotation 5 ILE S  90
LEU S  73
TYR S  71
LEU S  10
LEU S  60
 None
 1.21A 2bxfA-5mdjS:
undetectable		 2bxfA-5mdjS:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		5 LEU A 269
LEU A 252
CYH A 235
GLU A 324
LEU A 325
 None
 0.98A 2bxfA-5mqmA:
undetectable		 2bxfA-5mqmA:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 10 ILE A 387
ASN A 390
PHE A 402
LEU A 406
TYR A 410
LEU A 429
VAL A 432
GLU A 449
LEU A 452
ARG A 484
 None
 0.87A 2bxfA-5oriA:
45.7		 2bxfA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3p PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7

(Homo sapiens) 		PF00293
(NUDIX) 		5 PHE A  74
LEU A  56
LEU A  47
VAL A 126
LEU A  24
 None
 1.15A 2bxfA-5t3pA:
undetectable		 2bxfA-5t3pA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 PHE A 990
LEU A 812
LEU A 815
GLU A 838
LEU A 839
 None
 1.19A 2bxfA-5t8vA:
undetectable		 2bxfA-5t8vA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A

(Homo sapiens) 		PF00628
(PHD)
PF01388
(ARID)
PF02373
(JmjC)
PF02375
(JmjN)
PF02928
(zf-C5HC2)
PF08429
(PLU-1) 		5 ILE A 484
LEU A 545
VAL A 506
GLU A 515
LEU A 514
 None
 1.12A 2bxfA-5v9pA:
undetectable		 2bxfA-5v9pA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 LEU A 166
LEU A 133
VAL A 108
GLU A 117
LEU A 120
 None
 1.15A 2bxfA-5vxcA:
undetectable		 2bxfA-5vxcA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1a MYOSIN HEAVY CHAIN,
MUSCLE

(Drosophila
melanogaster) 		no annotation 5 ILE A 423
CYH A 427
LEU A 617
VAL A 383
LEU A 394
 None
 1.16A 2bxfA-5w1aA:
undetectable		 2bxfA-5w1aA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8p HOMOSERINE
O-ACETYLTRANSFERASE

(Mycobacteroides
abscessus) 		PF00561
(Abhydrolase_1) 		5 LEU A 183
VAL A 320
CYH A 345
GLU A 369
LEU A 370
 None
 1.22A 2bxfA-5w8pA:
undetectable		 2bxfA-5w8pA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrj PROTEIN-TYROSINE
SULFOTRANSFERASE 1

(Homo sapiens) 		PF13469
(Sulfotransfer_3) 		5 ILE A 145
PHE A  73
LEU A 170
TYR A 169
LEU A 173
 None
 1.21A 2bxfA-5wrjA:
undetectable		 2bxfA-5wrjA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrl AP-2 COMPLEX SUBUNIT
MU

(Rattus
norvegicus) 		no annotation 5 ILE A 266
LEU A 404
LEU A 173
CYH A 251
LEU A 206
 None
 1.25A 2bxfA-5wrlA:
undetectable		 2bxfA-5wrlA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x89 ENDA-LIKE
PROTEIN,TRNA-SPLICIN
G ENDONUCLEASE

(Methanopyrus
kandleri) 		no annotation 5 LEU A 275
TYR A 280
VAL A 337
GLU A 175
LEU A 176
 None
 1.24A 2bxfA-5x89A:
undetectable		 2bxfA-5x89A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE

(Aspergillus
kawachii) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 ILE A 598
PHE A 610
LEU A 485
LEU A 565
LEU A 567
 None
 1.21A 2bxfA-5xh9A:
undetectable		 2bxfA-5xh9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yax SCFV1 ANTIBODY

(Homo sapiens) 		no annotation 5 TYR A1102
LEU A1124
VAL A1126
LEU A1094
ARG A1075
 None
 1.23A 2bxfA-5yaxA:
undetectable		 2bxfA-5yaxA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 9 ASN A 391
PHE A 403
LEU A 407
TYR A 411
LEU A 430
VAL A 433
GLU A 450
LEU A 453
ARG A 485
 None
 0.84A 2bxfA-5yxeA:
47.2		 2bxfA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btg FUCULOSE PHOSPHATE
ALDOLASE

(Bacillus
thuringiensis) 		no annotation 5 ILE A 118
CYH A 179
LEU A 159
VAL A 172
ARG A 149
 None
 1.10A 2bxfA-6btgA:
undetectable		 2bxfA-6btgA:
10.47