SIMILAR PATTERNS OF AMINO ACIDS FOR 2BXE_B_1FLB2003

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbk PROTEIN
(7,8-DIHYDRO-6-HYDRO
XYMETHYLPTERIN-PYROP
HOSPHOKINASE)

(Haemophilus
influenzae) 		PF01288
(HPPK) 		5 LEU A  94
LEU A  19
LEU A  23
ILE A  26
ALA A   7
 None
 1.15A 2bxeB-1cbkA:
undetectable		 2bxeB-1cbkA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dvk PRP18

(Saccharomyces
cerevisiae) 		PF02840
(Prp18) 		5 LEU A 147
LEU A 121
ARG A 235
LEU A 236
ALA A 142
 None
 0.97A 2bxeB-1dvkA:
undetectable		 2bxeB-1dvkA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dvk PRP18

(Saccharomyces
cerevisiae) 		PF02840
(Prp18) 		5 LEU A 147
LEU A 121
LEU A 236
ILE A 233
ALA A 142
 None
 1.12A 2bxeB-1dvkA:
undetectable		 2bxeB-1dvkA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1faw HEMOGLOBIN (ALPHA
SUBUNIT)

(Anser anser) 		PF00042
(Globin) 		5 PHE A 128
LEU A 136
HIS A  87
ILE A  76
ALA A  65
 None
None
HEM  A 150 (-3.4A)
None
HEM  A 150 ( 4.0A)
 1.00A 2bxeB-1fawA:
2.4		 2bxeB-1fawA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A 385
PHE A 331
LEU A 400
HIS A 403
ILE A 464
 None
NAG  A 602 ( 4.5A)
None
None
None
 1.03A 2bxeB-1hfuA:
undetectable		 2bxeB-1hfuA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjf ENDO-1,4-BETA-XYLANA
SE Z

(Ruminiclostridium
thermocellum) 		PF00756
(Esterase) 		5 LEU A 269
LEU A  84
LEU A 120
ILE A 117
ALA A 276
 None
 1.11A 2bxeB-1jjfA:
undetectable		 2bxeB-1jjfA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kj9 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE 2

(Escherichia
coli) 		PF02222
(ATP-grasp) 		5 LEU A 308
PHE A 307
LEU A  34
ARG A  33
ALA A 301
 None
 1.06A 2bxeB-1kj9A:
undetectable		 2bxeB-1kj9A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr4 PROTEIN TM1056, CUTA

(Thermotoga
maritima) 		PF03091
(CutA1) 		5 LEU A  75
HIS A  79
LEU A  27
ILE A  33
ALA A  59
 None
 1.02A 2bxeB-1kr4A:
undetectable		 2bxeB-1kr4A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5j PERIPLASMIC DIVALENT
CATION TOLERANCE
PROTEIN

(Thermotoga
maritima) 		PF03091
(CutA1) 		5 LEU A  69
HIS A  73
LEU A  21
ILE A  27
ALA A  53
 None
 0.96A 2bxeB-1o5jA:
undetectable		 2bxeB-1o5jA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 LEU A 399
LEU A 369
ARG A 420
LEU A 421
ALA A 416
 None
 0.91A 2bxeB-1r20A:
undetectable		 2bxeB-1r20A:
17.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 TYR A 150
LEU A 219
ARG A 222
PHE A 223
HIS A 242
ARG A 257
ALA A 291
 DKA  A1003 (-4.4A)
None
CIT  A2001 ( 2.9A)
None
DKA  A1003 (-3.7A)
DKA  A1003 (-4.1A)
CIT  A2001 ( 3.9A)
 0.82A 2bxeB-1tf0A:
47.7		 2bxeB-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		9 TYR A 150
LEU A 219
PHE A 223
LEU A 238
HIS A 242
ARG A 257
LEU A 260
ILE A 264
ALA A 291
 DKA  A1003 (-4.4A)
None
None
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
DKA  A1003 (-4.1A)
None
None
CIT  A2001 ( 3.9A)
 0.34A 2bxeB-1tf0A:
47.7		 2bxeB-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhf PERIPLASMIC DIVALENT
CATION TOLERANCE
PROTEIN

(Thermotoga
maritima) 		PF03091
(CutA1) 		5 LEU A  69
HIS A  73
LEU A  21
ILE A  27
ALA A  53
 None
 0.95A 2bxeB-1vhfA:
undetectable		 2bxeB-1vhfA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		5 LEU A 244
PHE A 245
LEU A 110
LEU A 317
ALA A 323
 None
 1.06A 2bxeB-2amcA:
undetectable		 2bxeB-2amcA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Sulfolobus
solfataricus) 		PF00218
(IGPS) 		5 TYR A  69
LEU A  33
ARG A  36
LEU A 231
ALA A  77
 None
 1.12A 2bxeB-2c3zA:
undetectable		 2bxeB-2c3zA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 LEU A   3
PHE A 218
LEU A  70
LEU A 104
ILE A 222
 None
 0.99A 2bxeB-2dc0A:
undetectable		 2bxeB-2dc0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		5 LEU A 192
PHE A 189
LEU A 143
LEU A 129
ILE A 163
 None
 0.82A 2bxeB-2dh3A:
undetectable		 2bxeB-2dh3A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drw D-AMINO ACID AMIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase) 		5 LEU A 259
PHE A 255
LEU A 265
LEU A  72
ALA A  67
 None
 1.05A 2bxeB-2drwA:
undetectable		 2bxeB-2drwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eia EIAV CAPSID PROTEIN
P26

(Equine
infectious
anemia virus) 		PF00607
(Gag_p24) 		5 TYR A 129
LEU A  32
LEU A  57
LEU A  71
ALA A 136
 None
 1.08A 2bxeB-2eiaA:
undetectable		 2bxeB-2eiaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmy CARBON MONOXIDE
OXIDATION SYSTEM
TRANSCRIPTION
REGULATOR COOA-1

(Carboxydothermus
hydrogenoformans) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 LEU A 206
ARG A 200
LEU A 148
LEU A 214
ILE A 197
 None
 1.13A 2bxeB-2fmyA:
undetectable		 2bxeB-2fmyA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		5 LEU A 150
ARG A 117
LEU A 146
LEU A 100
ALA A 114
 None
 1.15A 2bxeB-2g37A:
undetectable		 2bxeB-2g37A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8x URACIL-DNA
GLYCOSYLASE

(Human
gammaherpesvirus
4) 		PF03167
(UDG) 		5 TYR A  93
PHE A 236
LEU A 137
LEU A 147
ILE A  87
 None
 1.06A 2bxeB-2j8xA:
undetectable		 2bxeB-2j8xA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jj7 HEMOLYSIN II
REGULATORY PROTEIN

(Bacillus cereus) 		PF00440
(TetR_N) 		5 LEU A 133
PHE A 142
LEU A  87
ILE A 177
ALA A  82
 None
 1.11A 2bxeB-2jj7A:
3.2		 2bxeB-2jj7A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjm GLYCOSYL
TRANSFERASE, GROUP 1
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 LEU A 335
LEU A 201
LEU A 276
ILE A 299
ALA A 328
 None
 0.98A 2bxeB-2jjmA:
undetectable		 2bxeB-2jjmA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbb TALIN-1

(Mus musculus) 		no annotation 5 LEU A1775
LEU A1716
LEU A1712
ILE A1709
ALA A1735
 None
 1.09A 2bxeB-2kbbA:
3.3		 2bxeB-2kbbA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6i HD DOMAIN PROTEIN

(Enterococcus
faecalis) 		PF01966
(HD) 		5 LEU A 204
HIS A  21
LEU A 208
ILE A 211
ALA A 182
 None
 1.05A 2bxeB-2o6iA:
undetectable		 2bxeB-2o6iA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqa LUFFACULIN 1

(Luffa
acutangula) 		PF00161
(RIP) 		5 LEU A 238
ARG A 162
LEU A  25
ILE A  18
ALA A 158
 None
 1.12A 2bxeB-2oqaA:
undetectable		 2bxeB-2oqaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 LEU A 512
PHE A 509
LEU A 497
ILE A 341
ALA A 336
 None
 1.14A 2bxeB-2pi5A:
3.8		 2bxeB-2pi5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		5 LEU A 202
ARG A 199
PHE A 201
LEU A 267
ALA A 296
 None
 1.10A 2bxeB-2pziA:
undetectable		 2bxeB-2pziA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qps ALPHA-AMYLASE TYPE A
ISOZYME

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		5 TYR A 185
LEU A 117
LEU A 161
HIS A 152
LEU A 165
 None
 1.13A 2bxeB-2qpsA:
undetectable		 2bxeB-2qpsA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r80 HEMOGLOBIN SUBUNIT
ALPHA-A

(Columba livia) 		PF00042
(Globin) 		5 PHE A 128
LEU A 136
HIS A  87
ILE A  76
ALA A  65
 None
None
HEM  A 150 (-3.3A)
None
HEM  A 150 ( 4.0A)
 0.99A 2bxeB-2r80A:
2.3		 2bxeB-2r80A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN

(Shigella
flexneri) 		PF00497
(SBP_bac_3) 		5 LEU A  10
PHE A 222
LEU A  63
ILE A  19
ALA A  53
 None
 1.13A 2bxeB-2vhaA:
undetectable		 2bxeB-2vhaA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvr RIBOSE-5-PHOSPHATE
ISOMERASE B

(Escherichia
coli) 		PF02502
(LacAB_rpiB) 		5 LEU A 105
PHE A 107
ARG A  26
LEU A  23
ILE A  19
 None
 0.96A 2bxeB-2vvrA:
undetectable		 2bxeB-2vvrA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 TYR A 453
PHE A 267
LEU A 375
LEU A 400
ILE A 297
 None
 1.12A 2bxeB-2wdwA:
undetectable		 2bxeB-2wdwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  83
LEU A  85
LEU A  66
ILE A  48
ALA A  97
 None
 1.09A 2bxeB-2z63A:
undetectable		 2bxeB-2z63A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A  83
LEU A  85
LEU A  66
ILE A  48
ALA A  97
 None
 1.07A 2bxeB-2z65A:
undetectable		 2bxeB-2z65A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at6 ALPHAA-GLOBIN

(Podocnemis
unifilis) 		PF00042
(Globin) 		5 PHE A 128
LEU A 136
HIS A  87
ILE A  76
ALA A  65
 None
None
HEM  A 142 (-3.3A)
None
HEM  A 142 (-3.5A)
 1.08A 2bxeB-3at6A:
undetectable		 2bxeB-3at6A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw8 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Thermus
thermophilus) 		PF02222
(ATP-grasp) 		5 TYR A  65
LEU A 245
PHE A 256
LEU A 237
ALA A  94
 None
 1.14A 2bxeB-3aw8A:
undetectable		 2bxeB-3aw8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b89 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		5 LEU A 176
LEU A 191
LEU A 194
ILE A 110
ALA A 200
 None
 1.04A 2bxeB-3b89A:
3.0		 2bxeB-3b89A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		5 LEU B 367
LEU B   4
HIS B   9
LEU B 326
ALA B 353
 None
 1.09A 2bxeB-3draB:
undetectable		 2bxeB-3draB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efv PUTATIVE
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Salmonella
enterica) 		PF00171
(Aldedh) 		5 ARG A 411
LEU A 404
LEU A 244
ILE A 242
ALA A 380
 None
 0.93A 2bxeB-3efvA:
undetectable		 2bxeB-3efvA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  83
LEU A  85
LEU A  66
ILE A  48
ALA A  97
 None
 1.12A 2bxeB-3fxiA:
undetectable		 2bxeB-3fxiA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1w MANNOSE-6-PHOSPHATE
ISOMERASE

(Salmonella
enterica) 		PF01238
(PMI_typeI) 		5 LEU A  81
PHE A  83
LEU A  58
LEU A   4
ILE A 342
 None
 1.08A 2bxeB-3h1wA:
2.1		 2bxeB-3h1wA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuu PUTATIVE
METALLOPEPTIDASE

(Chelativorans
sp. BNC1) 		PF07171
(MlrC_C)
PF07364
(DUF1485) 		5 LEU A 123
ARG A 124
LEU A 101
LEU A 103
ALA A 151
 None
 1.10A 2bxeB-3iuuA:
2.1		 2bxeB-3iuuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Thermococcus
kodakarensis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 TYR A  91
LEU A 304
LEU A 126
LEU A 123
ILE A 296
 None
 1.08A 2bxeB-3kdnA:
undetectable		 2bxeB-3kdnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2k EHPF

(Pantoea
agglomerans) 		PF00501
(AMP-binding) 		5 LEU A 198
LEU A 216
LEU A 213
ILE A 233
ALA A 138
 None
 1.09A 2bxeB-3l2kA:
undetectable		 2bxeB-3l2kA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9v FAD-DEPENDENT
OXIDOREDUCTASE

(Actinomadura
kijaniata) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  57
LEU A  29
LEU A  33
ILE A  36
ALA A  97
 None
 1.04A 2bxeB-3m9vA:
undetectable		 2bxeB-3m9vA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9p PERIPLASMIC MUREIN
PEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 LEU A 158
PHE A 164
LEU A 152
LEU A 148
ILE A 118
 None
 0.98A 2bxeB-3o9pA:
2.1		 2bxeB-3o9pA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8x ZETA-TOXIN

(Streptococcus
pyogenes) 		PF06414
(Zeta_toxin) 		5 PHE B  69
LEU B  20
LEU B 106
ILE B  64
ALA B 101
 None
 1.14A 2bxeB-3q8xB:
2.3		 2bxeB-3q8xB:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpw ABC TRANSPORTER

(Rhodopseudomonas
palustris) 		PF13416
(SBP_bac_8) 		5 LEU A 118
LEU A 285
LEU A 281
ILE A 105
ALA A 132
 None
 1.11A 2bxeB-3rpwA:
undetectable		 2bxeB-3rpwA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)

(Bacillus
halodurans) 		PF00496
(SBP_bac_5) 		5 LEU A 381
PHE A 350
LEU A 330
ILE A 359
ALA A 261
 None
 1.06A 2bxeB-3t66A:
undetectable		 2bxeB-3t66A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		5 LEU A 113
LEU A 108
LEU A 130
ILE A 143
ALA A 120
 None
 1.14A 2bxeB-3t6qA:
undetectable		 2bxeB-3t6qA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		5 LEU A 244
PHE A 245
LEU A 110
LEU A 317
ALA A 323
 None
 1.09A 2bxeB-3tehA:
undetectable		 2bxeB-3tehA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr7 URACIL-DNA
GLYCOSYLASE

(Coxiella
burnetii) 		PF03167
(UDG) 		5 TYR A  69
PHE A 205
LEU A 113
LEU A 123
ILE A  63
 None
 1.10A 2bxeB-3tr7A:
undetectable		 2bxeB-3tr7A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		6 TYR A 718
LEU A 758
LEU A 630
LEU A 627
ILE A 765
ALA A 747
 None
 1.38A 2bxeB-3u44A:
undetectable		 2bxeB-3u44A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umc HALOACID
DEHALOGENASE

(Pseudomonas
aeruginosa) 		PF13419
(HAD_2) 		5 LEU A  34
PHE A  23
LEU A  81
LEU A  83
ILE A  91
 None
 1.15A 2bxeB-3umcA:
undetectable		 2bxeB-3umcA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umc HALOACID
DEHALOGENASE

(Pseudomonas
aeruginosa) 		PF13419
(HAD_2) 		5 LEU A  34
PHE A  23
LEU A  87
ILE A  91
ALA A  76
 None
 1.04A 2bxeB-3umcA:
undetectable		 2bxeB-3umcA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4u HEMOGLOBIN SUBUNIT
ZETA

(Homo sapiens) 		PF00042
(Globin) 		5 PHE A 128
LEU A 136
HIS A  87
ILE A  76
ALA A  65
 None
None
HEM  A 201 ( 3.2A)
None
HEM  A 201 ( 3.7A)
 1.06A 2bxeB-3w4uA:
2.1		 2bxeB-3w4uA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtg HEMOGLOBIN SUBUNIT
ALPHA-A

(Dromaius
novaehollandiae) 		PF00042
(Globin) 		5 PHE A 128
LEU A 136
HIS A  87
ILE A  76
ALA A  65
 None
None
HEM  A 201 ( 3.2A)
None
HEM  A 201 ( 3.8A)
 0.97A 2bxeB-3wtgA:
2.1		 2bxeB-3wtgA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akk NITRATE REGULATORY
PROTEIN

(Klebsiella
oxytoca) 		PF03861
(ANTAR)
PF08376
(NIT) 		5 LEU A  86
PHE A  82
LEU A  97
ILE A 142
ALA A 102
 None
 1.01A 2bxeB-4akkA:
undetectable		 2bxeB-4akkA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 116
HIS A 120
LEU A 144
ILE A 134
ALA A 188
 None
CL  A1287 (-4.1A)
None
None
None
 1.10A 2bxeB-4b9dA:
undetectable		 2bxeB-4b9dA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 PHE A 389
HIS A 441
LEU A 434
ILE A 421
ALA A 416
 None
 0.93A 2bxeB-4bjuA:
undetectable		 2bxeB-4bjuA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT

(Homo sapiens) 		PF16203
(ERCC3_RAD25_C) 		5 LEU A 662
LEU A 547
HIS A 551
LEU A 693
ALA A 508
 None
 0.97A 2bxeB-4ernA:
undetectable		 2bxeB-4ernA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5n URACIL-DNA
GLYCOSYLASE

(Human
alphaherpesvirus
1) 		PF03167
(UDG) 		5 TYR A  90
PHE A 225
LEU A 135
LEU A 145
ILE A  84
 None
 1.06A 2bxeB-4l5nA:
undetectable		 2bxeB-4l5nA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhs UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14606
(Lipase_GDSL_3)
PF14607
(GxDLY) 		5 LEU A 157
PHE A  50
LEU A 109
LEU A 149
ILE A  77
 None
 1.00A 2bxeB-4lhsA:
undetectable		 2bxeB-4lhsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu1 MAF-LIKE PROTEIN
YCEF

(Escherichia
coli) 		PF02545
(Maf) 		5 LEU A   6
ARG A  14
PHE A  24
LEU A 177
ALA A  15
 None
 1.01A 2bxeB-4lu1A:
2.0		 2bxeB-4lu1A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans) 		5 LEU B 491
LEU B 124
HIS B 129
LEU B 411
ALA B 437
 None
 0.94A 2bxeB-4mbgB:
undetectable		 2bxeB-4mbgB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		5 LEU A 472
PHE A 447
LEU A 612
LEU A 608
ILE A 425
 None
 1.13A 2bxeB-4n3sA:
undetectable		 2bxeB-4n3sA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmn REPLICATIVE DNA
HELICASE

(Aquifex
aeolicus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 LEU A 217
LEU A 243
LEU A 286
ILE A 284
ALA A 314
 None
 1.09A 2bxeB-4nmnA:
undetectable		 2bxeB-4nmnA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oun MINI-RIBONUCLEASE 3

(Bacillus
subtilis) 		PF00636
(Ribonuclease_3) 		5 LEU A 129
PHE A  46
LEU A  85
ILE A  81
ALA A 146
 None
 0.93A 2bxeB-4ounA:
2.6		 2bxeB-4ounA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 LEU A 735
ARG A 785
LEU A 782
ILE A 778
ALA A 726
 None
 0.85A 2bxeB-4p72A:
undetectable		 2bxeB-4p72A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 LEU A1025
PHE A 750
LEU A 787
LEU A 779
ILE A 775
 None
 0.95A 2bxeB-4pj6A:
undetectable		 2bxeB-4pj6A:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 LEU A 219
PHE A 223
LEU A 238
HIS A 242
LEU A 260
ILE A 290
 None
 1.48A 2bxeB-4po0A:
48.1		 2bxeB-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 TYR A 150
ARG A 222
LEU A 238
HIS A 242
ARG A 257
LEU A 260
 None
 0.80A 2bxeB-4po0A:
48.1		 2bxeB-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		7 TYR A 150
LEU A 219
PHE A 223
LEU A 238
HIS A 242
ARG A 257
LEU A 260
 None
 0.52A 2bxeB-4po0A:
48.1		 2bxeB-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		5 LEU A 375
HIS A 188
ARG A 373
LEU A 445
ALA A 437
 None
 1.14A 2bxeB-4s3pA:
undetectable		 2bxeB-4s3pA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		5 LEU A 228
PHE A 226
LEU A 193
LEU A 157
ALA A 214
 None
 0.96A 2bxeB-4tx8A:
undetectable		 2bxeB-4tx8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0z ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD

(Homo sapiens) 		PF02661
(Fic) 		5 LEU A 426
HIS A 347
LEU A 381
ILE A 389
ALA A 419
 None
 1.11A 2bxeB-4u0zA:
undetectable		 2bxeB-4u0zA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 741
LEU A 748
HIS A 669
LEU A 798
ALA A 805
 None
 1.13A 2bxeB-4zdnA:
undetectable		 2bxeB-4zdnA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		5 LEU A 455
PHE A 452
LEU A 440
ILE A 484
ALA A 470
 None
 1.14A 2bxeB-5a5tA:
2.1		 2bxeB-5a5tA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT E

(Oryctolagus
cuniculus) 		PF01399
(PCI)
PF05470
(eIF-3c_N)
PF09440
(eIF3_N) 		5 LEU C 594
HIS E  12
LEU C 588
ILE C 573
ALA C 568
 None
 1.12A 2bxeB-5a5tC:
2.6		 2bxeB-5a5tC:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		9 TYR A 149
LEU A 218
PHE A 222
LEU A 237
HIS A 241
ARG A 256
LEU A 259
ILE A 263
ALA A 290
 PG4  A 602 (-4.9A)
None
None
PG4  A 602 (-4.7A)
PG4  A 602 (-4.0A)
PG4  A 602 (-4.1A)
PG4  A 602 ( 4.5A)
None
PG4  A 602 (-3.4A)
 0.43A 2bxeB-5dqfA:
48.1		 2bxeB-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5o NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		5 LEU A  59
PHE A 132
LEU A  52
ILE A 185
ALA A  41
 None
 1.10A 2bxeB-5f5oA:
undetectable		 2bxeB-5f5oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf DNA REPAIR HELICASE
RAD25, SSL2

(Saccharomyces
cerevisiae) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		5 LEU 1 708
LEU 1 594
HIS 1 598
LEU 1 739
ALA 1 555
 None
 0.97A 2bxeB-5fmf1:
undetectable		 2bxeB-5fmf1:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		7 TYR A 150
ARG A 222
LEU A 238
HIS A 242
ARG A 257
LEU A 260
ALA A 291
 None
 0.73A 2bxeB-5ghkA:
46.3		 2bxeB-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		8 TYR A 150
LEU A 219
PHE A 223
LEU A 238
HIS A 242
ARG A 257
LEU A 260
ALA A 291
 None
 0.42A 2bxeB-5ghkA:
46.3		 2bxeB-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASB

(Escherichia
coli) 		PF09485
(CRISPR_Cse2) 		5 LEU B 117
LEU B  87
LEU B 128
ILE B  72
ALA B 124
 None
 1.06A 2bxeB-5h9fB:
1.9		 2bxeB-5h9fB:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgg ALPHA CHAIN

(Acipenser
persicus) 		PF00042
(Globin) 		5 PHE A 129
LEU A 137
HIS A  88
ILE A  77
ALA A  66
 None
None
HEM  A 201 (-3.3A)
None
HEM  A 201 ( 3.7A)
 1.05A 2bxeB-5jggA:
2.2		 2bxeB-5jggA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnz ALPHA CHAIN

(Acipenser
stellatus) 		PF00042
(Globin) 		5 PHE A 129
LEU A 137
HIS A  88
ILE A  77
ALA A  66
 None
None
HEM  A 201 (-3.4A)
None
HEM  A 201 ( 3.8A)
 1.04A 2bxeB-5jnzA:
2.0		 2bxeB-5jnzA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kei 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 112
PHE A 108
LEU A 209
ARG A 225
ALA A 262
 None
 1.12A 2bxeB-5keiA:
undetectable		 2bxeB-5keiA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1t PENTALENOLACTONE
SYNTHASE

(Streptomyces
arenae) 		PF00067
(p450) 		5 LEU A 249
LEU A 371
LEU A 136
ILE A 394
ALA A 374
 None
 1.14A 2bxeB-5l1tA:
2.4		 2bxeB-5l1tA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m42 PROLINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		5 LEU A 150
ARG A 117
LEU A 146
LEU A 100
ALA A 114
 None
 1.13A 2bxeB-5m42A:
undetectable		 2bxeB-5m42A:
19.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 6 LEU A 218
ARG A 217
ARG A 256
LEU A 259
ILE A 263
ALA A 290
 None
 1.09A 2bxeB-5oriA:
47.9		 2bxeB-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 9 TYR A 149
LEU A 218
PHE A 222
LEU A 237
HIS A 241
ARG A 256
LEU A 259
ILE A 263
ALA A 290
 None
 0.59A 2bxeB-5oriA:
47.9		 2bxeB-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN

(Vibrio
vulnificus) 		no annotation 5 LEU A3598
LEU A3620
HIS A3624
LEU A3638
ILE A3642
 LEU  A3598 ( 0.6A)
LEU  A3620 ( 0.6A)
HIS  A3624 ( 1.0A)
LEU  A3638 ( 0.6A)
ILE  A3642 ( 0.7A)
 1.08A 2bxeB-5w6lA:
3.7		 2bxeB-5w6lA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsq NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		5 LEU A  43
PHE A 116
LEU A  36
ILE A 169
ALA A  25
 None
 1.02A 2bxeB-5xsqA:
2.4		 2bxeB-5xsqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 8 TYR A 150
LEU A 219
PHE A 223
LEU A 238
HIS A 242
ARG A 257
LEU A 260
ILE A 264
 None
 0.64A 2bxeB-5yxeA:
46.3		 2bxeB-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yzc GLYCOPROTEIN
F1,MEASLES VIRUS
FUSION PROTEIN
GLYCOPROTEIN F2

(Measles
morbillivirus) 		no annotation 5 LEU B 216
PHE B 217
LEU B 238
ILE A  56
ALA B 267
 None
 1.10A 2bxeB-5yzcB:
undetectable		 2bxeB-5yzcB:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5

(Aquareovirus C) 		no annotation 5 LEU 4  27
PHE 4  37
LEU 4 209
ILE 4   4
ALA 4 243
 None
 0.91A 2bxeB-5zvs4:
undetectable		 2bxeB-5zvs4:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 5 LEU A2253
LEU A2303
LEU A2395
ILE A2391
ALA A2281
 None
 1.12A 2bxeB-6ez8A:
undetectable		 2bxeB-6ez8A:
6.81