SIMILAR PATTERNS OF AMINO ACIDS FOR 2BXE_B_1FLB2001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0j TRYPSIN

(Salmo salar) 		PF00089
(Trypsin) 		5 LEU A 163
ILE A 162
VAL A 199
GLY A 211
LEU A 160
 None
 0.97A 2bxeB-1a0jA:
undetectable		 2bxeB-1a0jA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a70 FERREDOXIN

(Spinacia
oleracea) 		PF00111
(Fer2) 		5 ILE A  24
VAL A  74
GLY A  49
LEU A  56
SER A  83
 None
 1.25A 2bxeB-1a70A:
undetectable		 2bxeB-1a70A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ILE A  93
CYH A 123
VAL A 175
GLY A 176
LEU A   3
 None
 1.07A 2bxeB-1cqjA:
undetectable		 2bxeB-1cqjA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ILE A  93
VAL A 175
GLY A 176
CYH A 123
LEU A   3
 None
 1.16A 2bxeB-1cqjA:
undetectable		 2bxeB-1cqjA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 LEU A 242
ILE A 243
VAL A 175
GLY A 174
LEU A 238
 None
None
PLP  A 501 ( 4.1A)
None
None
 1.21A 2bxeB-1d6sA:
undetectable		 2bxeB-1d6sA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 ILE A 434
PHE A 332
VAL A 292
LEU A 303
SER A 352
 None
 1.24A 2bxeB-1dedA:
0.0		 2bxeB-1dedA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		5 LEU A  44
ILE A  47
PHE A  31
VAL A  33
LEU A  81
 None
 1.21A 2bxeB-1e6zA:
undetectable		 2bxeB-1e6zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE

(Candida
albicans) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 LEU A 415
CYH A 396
VAL A 448
GLY A 447
LEU A 450
 None
 1.26A 2bxeB-1iylA:
undetectable		 2bxeB-1iylA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 ILE A 720
VAL A 674
GLY A 675
CYH A 678
LEU A 696
 None
 1.12A 2bxeB-1qgrA:
0.3		 2bxeB-1qgrA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo3 LY49A

(Mus musculus) 		PF00059
(Lectin_C)
PF08391
(Ly49) 		5 LEU C 218
ILE C 177
VAL C 197
GLY C 198
LEU C 240
 None
 1.28A 2bxeB-1qo3C:
undetectable		 2bxeB-1qo3C:
11.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		10 LEU A 387
ILE A 388
ASN A 391
PHE A 403
TYR A 411
LYS A 414
VAL A 433
GLY A 434
LEU A 453
SER A 489
 None
 0.69A 2bxeB-1tf0A:
47.7		 2bxeB-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wck BCLA PROTEIN

(Bacillus
anthracis) 		PF01391
(Collagen) 		5 LEU A 167
ILE A 174
VAL A 105
LEU A 200
SER A 146
 None
 1.22A 2bxeB-1wckA:
undetectable		 2bxeB-1wckA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjv PROTECTION OF
TELOMERES 1

(Homo sapiens) 		PF02765
(POT1)
PF16686
(POT1PC) 		5 LEU A 239
ILE A 241
VAL A 222
LEU A 181
SER A 237
 None
 1.21A 2bxeB-1xjvA:
undetectable		 2bxeB-1xjvA:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ysx SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 ASN A 391
CYH A 392
PHE A 403
TYR A 411
VAL A 433
 4EB  A1000 (-3.5A)
4EB  A1000 (-3.2A)
4EB  A1000 ( 4.1A)
4EB  A1000 (-3.3A)
None
 0.96A 2bxeB-1ysxA:
6.2		 2bxeB-1ysxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ysx SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 ASN A 391
CYH A 392
TYR A 411
VAL A 433
GLY A 434
 4EB  A1000 (-3.5A)
4EB  A1000 (-3.2A)
4EB  A1000 (-3.3A)
None
4EB  A1000 ( 4.7A)
 0.94A 2bxeB-1ysxA:
6.2		 2bxeB-1ysxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ysx SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 LEU A 387
ILE A 388
ASN A 391
CYH A 392
PHE A 403
TYR A 411
 None
4EB  A1000 ( 4.6A)
4EB  A1000 (-3.5A)
4EB  A1000 (-3.2A)
4EB  A1000 ( 4.1A)
4EB  A1000 (-3.3A)
 0.99A 2bxeB-1ysxA:
6.2		 2bxeB-1ysxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ysx SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LEU A 387
ILE A 388
CYH A 392
PHE A 403
LYS A 414
 None
4EB  A1000 ( 4.6A)
4EB  A1000 (-3.2A)
4EB  A1000 ( 4.1A)
4EB  A1000 (-3.9A)
 1.08A 2bxeB-1ysxA:
6.2		 2bxeB-1ysxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		5 LEU A 474
PHE A 766
VAL A 540
GLY A 539
LEU A 415
 None
 1.27A 2bxeB-1z26A:
undetectable		 2bxeB-1z26A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE

(Bacillus
anthracis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A 181
ILE A 179
VAL A 241
GLY A 243
LEU A 235
 None
 1.23A 2bxeB-2btuA:
undetectable		 2bxeB-2btuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eek TRYPSIN-1

(Gadus morhua) 		PF00089
(Trypsin) 		5 LEU A 163
ILE A 162
VAL A 199
GLY A 211
LEU A 160
 None
 0.97A 2bxeB-2eekA:
undetectable		 2bxeB-2eekA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B

(Homo sapiens) 		PF14580
(LRR_9) 		5 LEU A  67
ILE A  41
VAL A  59
GLY A  60
LEU A  56
 None
 1.13A 2bxeB-2ellA:
undetectable		 2bxeB-2ellA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es4 LIPASE CHAPERONE

(Burkholderia
glumae) 		PF03280
(Lipase_chap) 		5 LEU D 116
ILE D 112
VAL D 128
GLY D 127
LEU D  79
 None
 1.27A 2bxeB-2es4D:
undetectable		 2bxeB-2es4D:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i15 HYPOTHETICAL PROTEIN
MG296 HOMOLOG

(Mycoplasma
pneumoniae) 		PF09644
(Mg296) 		5 LEU A  97
ILE A 101
VAL A 125
GLY A 120
SER A  65
 None
 1.26A 2bxeB-2i15A:
undetectable		 2bxeB-2i15A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		5 ILE A 720
VAL A 674
GLY A 675
CYH A 678
LEU A 696
 None
 1.15A 2bxeB-2qnaA:
undetectable		 2bxeB-2qnaA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 ILE B 620
VAL B 628
GLY B 627
LEU B 515
SER A 105
 None
 1.11A 2bxeB-2rhqB:
undetectable		 2bxeB-2rhqB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-RELATED
GTP-BINDING PROTEIN
RHOE

(Homo sapiens) 		PF00071
(Ras) 		5 LEU B  40
VAL B 133
GLY B 134
CYH B 177
LEU B  99
 None
 1.27A 2bxeB-2v55B:
undetectable		 2bxeB-2v55B:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)

(Archaeoglobus
fulgidus) 		PF02492
(cobW) 		5 LEU A 113
ILE A  35
PHE A 207
VAL A 160
LEU A  46
 None
 1.26A 2bxeB-2wsmA:
undetectable		 2bxeB-2wsmA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE

(Nonomuraea
recticatena) 		PF00067
(p450) 		5 LEU A 243
ILE A 160
PHE A 217
VAL A 166
GLY A 165
 None
 1.14A 2bxeB-2z36A:
undetectable		 2bxeB-2z36A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		5 LEU A 770
ILE A 767
VAL A 751
GLY A 750
LEU A 456
 None
 1.19A 2bxeB-2znsA:
undetectable		 2bxeB-2znsA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zs0 EXTRACELLULAR GIANT
HEMOGLOBIN MAJOR
GLOBIN SUBUNIT B1

(Oligobrachia
mashikoi) 		PF00042
(Globin) 		5 ILE D  35
PHE D  61
VAL D  68
LEU D 110
SER D  43
 None
None
HEM  D 200 (-4.0A)
HEM  D 200 (-3.8A)
None
 1.24A 2bxeB-2zs0D:
2.7		 2bxeB-2zs0D:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdr YCF58 PROTEIN

(Synechococcus
elongatus) 		PF09367
(CpeS) 		5 LEU A 128
ILE A   7
GLY A  68
CYH A  67
LEU A 104
 None
 1.16A 2bxeB-3bdrA:
undetectable		 2bxeB-3bdrA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckm YRAM (HI1655)

(Haemophilus
influenzae) 		PF04348
(LppC) 		5 LEU A 329
ILE A 328
GLY A 318
LEU A 355
SER A 349
 None
 1.04A 2bxeB-3ckmA:
undetectable		 2bxeB-3ckmA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 ILE A 414
PHE A 381
TYR A 420
VAL A 427
LEU A 341
 None
P6G  A 628 ( 4.0A)
None
None
None
 1.27A 2bxeB-3ctzA:
undetectable		 2bxeB-3ctzA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 LEU A 213
ILE A 310
CYH A 203
GLY A 200
LEU A 225
 None
 1.26A 2bxeB-3d3uA:
undetectable		 2bxeB-3d3uA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE

(Pseudomonas
putida) 		PF13489
(Methyltransf_23) 		5 LEU A 140
ILE A 119
VAL A  79
GLY A  78
LEU A 105
 None
 1.00A 2bxeB-3e8sA:
undetectable		 2bxeB-3e8sA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbs OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF07992
(Pyr_redox_2) 		5 ILE A 105
CYH A 263
GLY A 280
LEU A  21
SER A 290
 None
 1.22A 2bxeB-3fbsA:
undetectable		 2bxeB-3fbsA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 LEU A1391
ILE A1392
ASN A1395
LEU A1406
SER A1411
 None
 1.07A 2bxeB-3ig3A:
undetectable		 2bxeB-3ig3A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jqy POLYSIALIC ACID
O-ACETYLTRANSFERASE

(Escherichia
coli) 		no annotation 5 ILE B  88
PHE B  42
VAL B  77
LEU B  75
SER B  50
 None
 1.20A 2bxeB-3jqyB:
undetectable		 2bxeB-3jqyB:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktn CARBOHYDRATE KINASE,
PFKB FAMILY

(Enterococcus
faecalis) 		PF00294
(PfkB) 		5 LEU A 140
ILE A 136
CYH A 134
GLY A  35
SER A 109
 None
SO4  A 401 ( 4.4A)
None
None
None
 1.21A 2bxeB-3ktnA:
undetectable		 2bxeB-3ktnA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgg ADENOSINE DEAMINASE
CECR1

(Homo sapiens) 		PF00962
(A_deaminase)
PF08451
(A_deaminase_N) 		5 LEU A  87
ILE A 219
PHE A 257
GLY A 259
SER A 413
 None
 1.12A 2bxeB-3lggA:
undetectable		 2bxeB-3lggA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT

(Mycobacterium
marinum) 		PF00797
(Acetyltransf_2) 		5 LEU A 266
ILE A 270
GLY A 223
CYH A 274
LEU A 249
 None
 1.16A 2bxeB-3ltwA:
undetectable		 2bxeB-3ltwA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2s RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
SSU72

(Homo sapiens) 		PF04722
(Ssu72) 		5 LEU B 154
ILE B 155
CYH B 159
VAL B 137
SER B 183
 None
 1.18A 2bxeB-3o2sB:
undetectable		 2bxeB-3o2sB:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o59 DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
horikoshii) 		PF03833
(PolC_DP2) 		5 ILE X 125
VAL X 164
GLY X 165
LEU X 110
SER X 153
 None
 1.06A 2bxeB-3o59X:
2.4		 2bxeB-3o59X:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN

(Chloroflexus
aurantiacus) 		PF13560
(HTH_31) 		5 LEU A  36
ILE A  41
VAL A  10
GLY A   7
LEU A  60
 None
 1.20A 2bxeB-3pxpA:
undetectable		 2bxeB-3pxpA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdq 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Clostridium
aminobutyricum) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 LEU A 212
ILE A 309
CYH A 202
GLY A 199
LEU A 224
 None
 1.15A 2bxeB-3qdqA:
undetectable		 2bxeB-3qdqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		5 LEU A 754
ILE A 751
VAL A 735
GLY A 734
LEU A 439
 None
 1.16A 2bxeB-3qxmA:
undetectable		 2bxeB-3qxmA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		5 ILE A 516
VAL A 580
GLY A 584
LEU A 536
SER A 607
 None
 1.13A 2bxeB-3r75A:
undetectable		 2bxeB-3r75A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		5 LEU A 512
ILE A 516
VAL A 586
GLY A 602
LEU A 536
 None
 1.13A 2bxeB-3r75A:
undetectable		 2bxeB-3r75A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8e HYPOTHETICAL SUGAR
KINASE

(Cytophaga
hutchinsonii) 		PF00480
(ROK) 		5 LEU A 233
ILE A 236
VAL A 141
GLY A 140
LEU A 242
 None
 1.13A 2bxeB-3r8eA:
undetectable		 2bxeB-3r8eA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 182
ILE A 208
VAL A 188
GLY A 186
LEU A 196
 None
 1.23A 2bxeB-3rr1A:
undetectable		 2bxeB-3rr1A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryt PLEXIN-A1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 LEU A1413
ILE A1414
ASN A1417
LEU A1428
SER A1433
 None
 0.92A 2bxeB-3rytA:
3.5		 2bxeB-3rytA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		5 LEU A 244
ILE A 245
VAL A 185
GLY A 184
LEU A 240
 None
None
LLP  A  51 ( 4.2A)
None
None
 1.11A 2bxeB-3tbhA:
undetectable		 2bxeB-3tbhA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		5 ILE A  24
LYS A  73
VAL A 104
GLY A 105
LEU A  50
 None
 1.12A 2bxeB-3tqsA:
undetectable		 2bxeB-3tqsA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		5 LEU A  21
ILE A  24
LYS A  73
VAL A 104
GLY A 105
 None
 1.22A 2bxeB-3tqsA:
undetectable		 2bxeB-3tqsA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tyj BCLA PROTEIN

(Bacillus
anthracis) 		no annotation 5 LEU A 167
ILE A 174
VAL A 105
LEU A 200
SER A 146
 None
 1.21A 2bxeB-3tyjA:
undetectable		 2bxeB-3tyjA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ast ALDO-KETO REDUCTASE
AKR14A1

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		5 TYR A 170
VAL A 217
GLY A 218
CYH A  18
LEU A 189
 None
 1.08A 2bxeB-4astA:
undetectable		 2bxeB-4astA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3w ENOYL-COA
HYDRATASE/ISOMERASE

(Marinobacter
hydrocarbonoclasticus) 		PF00378
(ECH_1) 		5 LEU A  10
ILE A  23
GLY A 123
CYH A  66
LEU A  58
 None
 0.99A 2bxeB-4k3wA:
2.5		 2bxeB-4k3wA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksi LEUCINE
AMINOPEPTIDASE 1,
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A  88
VAL A 208
GLY A 167
LEU A 227
SER A 177
 None
 1.30A 2bxeB-4ksiA:
undetectable		 2bxeB-4ksiA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0q MEMBRANE-ASSOCIATED
PROTEIN VP24

(Zaire
ebolavirus) 		PF06389
(Filo_VP24) 		5 LEU A 152
ILE A 153
ASN A 156
GLY A 101
LEU A 119
 None
 1.05A 2bxeB-4m0qA:
undetectable		 2bxeB-4m0qA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN

(Mus musculus) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		5 LEU A 339
ILE A 364
PHE A 419
VAL A 409
LEU A 428
 None
 1.15A 2bxeB-4m4dA:
undetectable		 2bxeB-4m4dA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU B 453
PHE B 385
GLY B 386
CYH B 435
LEU B 428
 None
 1.21A 2bxeB-4m69B:
undetectable		 2bxeB-4m69B:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o89 RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Pyrococcus
horikoshii) 		PF01137
(RTC)
PF05189
(RTC_insert) 		5 LEU A 132
ILE A 149
VAL A 168
GLY A 147
LEU A 103
 None
 1.27A 2bxeB-4o89A:
undetectable		 2bxeB-4o89A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obs ALPHA-L-IDURONIDASE

(Homo sapiens) 		PF01229
(Glyco_hydro_39) 		5 LEU A 353
VAL A  88
GLY A  51
LEU A  74
SER A  67
 None
 1.15A 2bxeB-4obsA:
undetectable		 2bxeB-4obsA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 5 ILE A 389
VAL A 341
GLY A 340
LEU A 354
SER A 261
 None
 0.78A 2bxeB-4oj5A:
undetectable		 2bxeB-4oj5A:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		9 LEU A 387
ASN A 391
PHE A 403
TYR A 411
LYS A 414
VAL A 433
GLY A 434
LEU A 453
SER A 489
 NPS  A 601 ( 4.7A)
NPS  A 601 (-4.3A)
None
NPS  A 601 (-4.3A)
NPS  A 601 (-2.7A)
None
None
NPS  A 601 (-4.7A)
NPS  A 601 (-3.1A)
 0.65A 2bxeB-4po0A:
48.1		 2bxeB-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s13 FERULIC ACID
DECARBOXYLASE 1

(Saccharomyces
cerevisiae) 		PF01977
(UbiD) 		5 PHE A  53
VAL A 316
GLY A  68
CYH A  69
LEU A 144
 None
 1.22A 2bxeB-4s13A:
undetectable		 2bxeB-4s13A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxd 2-DEHYDRO-3-DEOXY-D-
GLUCONATE/2-DEHYDRO-
3-DEOXY-PHOSPHOGLUCO
NATE ALDOLASE

(Picrophilus
torridus) 		PF00701
(DHDPS) 		5 LEU A 121
ILE A 120
VAL A  75
GLY A  76
SER A 154
 None
 0.99A 2bxeB-4uxdA:
undetectable		 2bxeB-4uxdA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uyg BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		5 LEU A 357
ILE A 356
PHE A 422
TYR A 373
VAL A 445
 None
 1.26A 2bxeB-4uygA:
2.3		 2bxeB-4uygA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhc ALPHA-L-RHAMNOSIDASE

(Klebsiella
oxytoca) 		PF17389
(Bac_rhamnosid6H) 		5 LEU A 205
ASN A 209
CYH A 210
GLY A 218
SER A  81
 None
 0.88A 2bxeB-4xhcA:
2.4		 2bxeB-4xhcA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydi ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		5 LEU G 342
ASN G 339
VAL G 333
LEU G 390
SER G 393
 None
 1.17A 2bxeB-4ydiG:
undetectable		 2bxeB-4ydiG:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 LEU A 410
ILE A 406
VAL A 374
GLY A 363
LEU A 390
 None
 0.96A 2bxeB-5dotA:
undetectable		 2bxeB-5dotA:
17.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		8 LEU A 386
ASN A 390
PHE A 402
TYR A 410
LYS A 413
GLY A 433
LEU A 452
SER A 488
 None
 0.65A 2bxeB-5dqfA:
48.1		 2bxeB-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		8 LEU A 386
ASN A 390
PHE A 402
TYR A 410
LYS A 413
VAL A 432
GLY A 433
SER A 488
 None
 0.52A 2bxeB-5dqfA:
48.1		 2bxeB-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt5 BETA-GLUCOSIDASE

(Exiguobacterium
antarcticum) 		PF00232
(Glyco_hydro_1) 		5 LEU A 194
ILE A 251
GLY A 215
CYH A 286
LEU A 218
 None
 1.27A 2bxeB-5dt5A:
undetectable		 2bxeB-5dt5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5o I-SMAMI LAGLIDADG
ENDONUCLEASE

(Sordaria
macrospora) 		PF00961
(LAGLIDADG_1) 		5 LEU A 213
VAL A 176
GLY A 180
LEU A 172
SER A 216
 None
 1.28A 2bxeB-5e5oA:
undetectable		 2bxeB-5e5oA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		5 LEU A 352
ILE A 348
VAL A 297
GLY A 298
LEU A 292
 None
 1.29A 2bxeB-5e7pA:
undetectable		 2bxeB-5e7pA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 CYH A 101
TYR A 269
GLY A 251
LEU A  24
SER A 602
 None
 1.11A 2bxeB-5erbA:
undetectable		 2bxeB-5erbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eu6 HUMAN TCR HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PHE E 215
TYR E 189
VAL E  13
GLY E 217
LEU E 115
 None
 1.24A 2bxeB-5eu6E:
undetectable		 2bxeB-5eu6E:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		5 ILE I 178
CYH I 176
TYR I 142
GLY I  15
LEU I 110
 None
 0.98A 2bxeB-5fmgI:
undetectable		 2bxeB-5fmgI:
17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		9 LEU A 387
ASN A 391
PHE A 403
TYR A 411
LYS A 414
VAL A 433
GLY A 434
LEU A 453
SER A 489
 None
 0.54A 2bxeB-5ghkA:
46.3		 2bxeB-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy0 GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 ILE A 105
PHE A 336
VAL A 445
GLY A 446
LEU A 114
 None
 1.26A 2bxeB-5gy0A:
undetectable		 2bxeB-5gy0A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huj NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptococcus
pyogenes) 		PF02540
(NAD_synthase) 		5 ILE A  15
PHE A 193
VAL A  21
GLY A  20
LEU A 246
 None
 1.14A 2bxeB-5hujA:
undetectable		 2bxeB-5hujA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		5 ILE A 122
VAL A 161
GLY A 162
LEU A 107
SER A 150
 None
 1.06A 2bxeB-5ijlA:
undetectable		 2bxeB-5ijlA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 LEU A 206
ILE A 203
GLY A 124
CYH A 175
LEU A 101
 None
 1.01A 2bxeB-5iuwA:
undetectable		 2bxeB-5iuwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh0 SMALL GTP-BINDING
PROTEIN

(Thermosipho
melanesiensis) 		PF01926
(MMR_HSR1) 		5 LEU A  53
PHE A 118
GLY A  91
CYH A  90
LEU A  61
 None
 1.08A 2bxeB-5kh0A:
undetectable		 2bxeB-5kh0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2x DNA-DIRECTED
PRIMASE/POLYMERASE
PROTEIN

(Homo sapiens) 		no annotation 5 LEU A 134
ILE A 135
CYH A 139
TYR A 284
CYH A 150
 None
 0.80A 2bxeB-5l2xA:
undetectable		 2bxeB-5l2xA:
20.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 9 LEU A 386
ILE A 387
ASN A 390
PHE A 402
TYR A 410
LYS A 413
GLY A 433
LEU A 452
SER A 488
 None
 0.92A 2bxeB-5oriA:
47.9		 2bxeB-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 9 LEU A 386
ILE A 387
ASN A 390
TYR A 410
LYS A 413
VAL A 432
GLY A 433
LEU A 452
SER A 488
 None
 0.92A 2bxeB-5oriA:
47.9		 2bxeB-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2o J30 CCH

(Thermobacillus
composti) 		no annotation 5 LEU A  95
VAL A 100
GLY A  99
CYH A 114
LEU A 184
 None
None
None
ZN  A 606 (-2.3A)
None
 1.28A 2bxeB-5u2oA:
undetectable		 2bxeB-5u2oA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u81 ACID CERAMIDASE
ISOFORM B

(Heterocephalus
glaber) 		no annotation 5 LEU A 236
ILE A 240
PHE A 108
GLY A 106
LEU A 101
 None
 1.20A 2bxeB-5u81A:
undetectable		 2bxeB-5u81A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uw2 PROBABLE
PHOSPHOLIPID ABC
TRANSPORTER-BINDING
PROTEIN MLAD

(Escherichia
coli) 		PF02470
(MlaD) 		5 LEU A 128
ILE A  93
VAL A  58
GLY A  66
LEU A  99
 None
 1.11A 2bxeB-5uw2A:
undetectable		 2bxeB-5uw2A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uw8 PROBABLE
PHOSPHOLIPID ABC
TRANSPORTER-BINDING
PROTEIN MLAD

(Escherichia
coli) 		PF02470
(MlaD) 		5 LEU A 128
ILE A  93
VAL A  58
GLY A  66
LEU A  99
 None
 1.11A 2bxeB-5uw8A:
undetectable		 2bxeB-5uw8A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vey HISTONE H2B TYPE
1-J,HISTONE H2A TYPE
1-B/E

(Homo sapiens) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		5 LEU A 140
ILE A  70
VAL A 132
GLY A 133
LEU A 123
 None
 1.27A 2bxeB-5veyA:
undetectable		 2bxeB-5veyA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5via PSEUDOPEROXIDASE

(Leishmania
major) 		PF00141
(peroxidase) 		5 ILE A  85
TYR A 235
VAL A 208
GLY A 209
LEU A 230
 HEM  A 500 ( 3.9A)
None
None
HEM  A 500 (-3.1A)
None
 1.15A 2bxeB-5viaA:
undetectable		 2bxeB-5viaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		no annotation 5 LEU G 349
ILE G 272
PHE G 288
GLY G 451
LEU G 454
 None
 1.19A 2bxeB-5wduG:
undetectable		 2bxeB-5wduG:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		5 LEU A 787
ASN A 791
TYR A 616
VAL A 795
GLY A 794
 None
 1.24A 2bxeB-5welA:
3.2		 2bxeB-5welA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 9 LEU A 387
ASN A 391
PHE A 403
TYR A 411
LYS A 414
VAL A 433
GLY A 434
LEU A 453
SER A 489
 None
 0.78A 2bxeB-5yxeA:
46.3		 2bxeB-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0n ENVELOPE
GLYCOPROTEIN GP140

(Human
immunodeficiency
virus 1) 		no annotation 5 LEU G 349
ILE G 272
PHE G 288
GLY G 451
LEU G 454
 None
 1.25A 2bxeB-6b0nG:
undetectable		 2bxeB-6b0nG:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8q NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Enterococcus
faecalis) 		no annotation 5 ILE A   8
PHE A 186
VAL A  14
GLY A  13
LEU A 239
 None
 1.21A 2bxeB-6c8qA:
undetectable		 2bxeB-6c8qA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE

(Mycobacterium
tuberculosis) 		no annotation 5 LEU C 218
VAL C 137
GLY C 114
LEU C 237
SER C 243
 None
 1.28A 2bxeB-6eicC:
undetectable		 2bxeB-6eicC:
10.36