SIMILAR PATTERNS OF AMINO ACIDS FOR 2BXE_A_1FLA2002

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbr PROTEIN (HEMOGLOBIN
D)


(Gallus gallus)
PF00042
(Globin)
5 ALA A  69
LEU A  76
SER A  84
LEU A 136
VAL A 135
None
1.11A 2bxeA-1hbrA:
2.1
2bxeA-1hbrA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hds HEMOGLOBIN S (DEOXY)
(ALPHA CHAIN)


(Odocoileus
virginianus)
PF00042
(Globin)
5 ALA A  69
LEU A  76
SER A  84
LEU A 136
VAL A 135
None
1.08A 2bxeA-1hdsA:
undetectable
2bxeA-1hdsA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kij DNA GYRASE SUBUNIT B

(Thermus
thermophilus)
PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
5 ALA A 348
ALA A 345
LEU A 340
LEU A 327
ALA A 270
None
1.02A 2bxeA-1kijA:
undetectable
2bxeA-1kijA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1li7 CYSTEINYL-TRNA
SYNTHETASE


(Escherichia
coli)
PF01406
(tRNA-synt_1e)
PF09190
(DALR_2)
5 PHE A 350
ALA A 355
LEU A 359
LEU A 391
VAL A  49
None
1.09A 2bxeA-1li7A:
undetectable
2bxeA-1li7A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogq POLYGALACTURONASE
INHIBITING PROTEIN


(Phaseolus
vulgaris)
PF08263
(LRRNT_2)
5 PHE A 293
ALA A 297
ALA A 229
SER A 272
LEU A 273
None
NAG  A1317 ( 4.0A)
None
None
None
1.07A 2bxeA-1ogqA:
undetectable
2bxeA-1ogqA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0h HEMOGLOBIN ALPHA
CHAIN


(Equus asinus)
PF00042
(Globin)
5 ALA A  69
LEU A  76
SER A  84
LEU A 136
VAL A 135
None
1.14A 2bxeA-1s0hA:
undetectable
2bxeA-1s0hA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1


(Mus musculus)
PF03036
(Perilipin)
5 ALA A 265
ALA A 269
LEU A 273
LEU A 405
ALA A 401
None
1.12A 2bxeA-1sziA:
2.4
2bxeA-1sziA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1


(Mus musculus)
PF03036
(Perilipin)
5 ALA A 265
ALA A 269
LEU A 273
LEU A 405
LEU A 262
None
1.24A 2bxeA-1sziA:
2.4
2bxeA-1sziA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC


(Escherichia
coli)
PF03009
(GDPD)
5 ALA A  52
ALA A  54
LEU A  62
LEU A 158
VAL A 155
None
1.20A 2bxeA-1t8qA:
undetectable
2bxeA-1t8qA:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
10 PHE A 206
ALA A 210
ALA A 213
LEU A 331
LEU A 347
ALA A 350
GLU A 354
SER A 480
LEU A 481
VAL A 482
None
DKA  A1002 (-3.3A)
DKA  A1001 ( 4.0A)
None
DKA  A1002 ( 4.3A)
DKA  A1002 ( 3.8A)
DKA  A1002 ( 4.4A)
DKA  A1002 (-3.4A)
None
DKA  A1002 (-4.2A)
0.46A 2bxeA-1tf0A:
47.5
2bxeA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN


(Human
alphaherpesvirus
1)
PF00747
(Viral_DNA_bp)
5 ALA A 319
ALA A 323
LEU A 678
LEU A 252
ALA A 251
None
1.19A 2bxeA-1urjA:
0.0
2bxeA-1urjA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Thermus
thermophilus)
PF14681
(UPRTase)
5 ALA A 142
ALA A 139
LEU A 133
LEU A 156
LEU A 146
None
SO4  A 517 (-4.1A)
None
None
None
1.22A 2bxeA-1v9sA:
undetectable
2bxeA-1v9sA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus)
PF00291
(PALP)
5 ALA A  55
ALA A  59
LEU A  62
LEU A  68
ALA A 138
None
1.02A 2bxeA-1ve5A:
undetectable
2bxeA-1ve5A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlv ORNITHINE
CARBAMOYLTRANSFERASE


(Thermotoga
maritima)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 ALA A  95
LEU A  91
LEU A 118
SER A   9
VAL A 126
None
1.17A 2bxeA-1vlvA:
undetectable
2bxeA-1vlvA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1


(Homo sapiens)
PF00619
(CARD)
PF00931
(NB-ARC)
5 ALA A 164
ALA A 167
LEU A 173
LEU A 140
VAL A 150
None
1.16A 2bxeA-1z6tA:
undetectable
2bxeA-1z6tA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST


(Spinacia
oleracea)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
5 ALA A 278
LEU A 335
GLU A 320
LEU A 260
VAL A 261
None
1.18A 2bxeA-2akjA:
2.0
2bxeA-2akjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens)
PF08704
(GCD14)
5 PHE A 186
LEU A  96
LEU A 121
ALA A 124
VAL A 131
None
0.75A 2bxeA-2b25A:
undetectable
2bxeA-2b25A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151


(Pyrobaculum
aerophilum)
PF01850
(PIN)
5 ALA A  26
ALA A  30
LEU A  33
LEU A 115
VAL A   5
None
1.13A 2bxeA-2fe1A:
undetectable
2bxeA-2fe1A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI


(Saccharopolyspora
erythraea)
PF08659
(KR)
5 ALA A1542
LEU A1549
ALA A1591
LEU A1778
VAL A1777
None
1.06A 2bxeA-2fr1A:
undetectable
2bxeA-2fr1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4


(Homo sapiens)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
5 ALA A 576
LEU A 544
LEU A 542
ALA A 610
VAL A 619
None
1.15A 2bxeA-2g5tA:
undetectable
2bxeA-2g5tA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfn GLUTAMATE RACEMASE

(Escherichia
coli)
PF01177
(Asp_Glu_race)
5 LEU A 168
LEU A 183
ALA A 182
LEU A 218
VAL A 217
None
1.16A 2bxeA-2jfnA:
undetectable
2bxeA-2jfnA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxx UNCHARACTERIZED
PROTEIN MGC2408


(Homo sapiens)
PF08241
(Methyltransf_11)
5 PHE A 124
LEU A  52
LEU A 128
LEU A  63
VAL A  64
None
1.19A 2bxeA-2pxxA:
undetectable
2bxeA-2pxxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra1 SURFACE LAYER
PROTEIN


(Geobacillus
stearothermophilus)
PF13205
(Big_5)
5 ALA A 211
ALA A 223
LEU A 220
ALA A 259
GLU A 257
None
1.11A 2bxeA-2ra1A:
3.4
2bxeA-2ra1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3c SIGNAL RECOGNITION
54 KDA PROTEIN


(Methanocaldococcus
jannaschii)
PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB)
5 LEU C   5
LEU C  38
ALA C  37
LEU C  47
VAL C  48
None
1.17A 2bxeA-2v3cC:
3.9
2bxeA-2v3cC:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw9 SINGLE-STRANDED DNA
BINDING PROTEIN


(Helicobacter
pylori)
PF00436
(SSB)
5 ALA A1099
LEU A1055
ALA A1063
LEU A1074
VAL A1073
None
1.06A 2bxeA-2vw9A:
undetectable
2bxeA-2vw9A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4d ACYLPHOSPHATASE

(Pyrococcus
horikoshii)
PF00708
(Acylphosphatase)
5 ALA A  46
LEU A   8
LEU A  48
ALA A   6
VAL A  32
None
1.24A 2bxeA-2w4dA:
undetectable
2bxeA-2w4dA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xua 3-OXOADIPATE
ENOL-LACTONASE


(Paraburkholderia
xenovorans)
PF12146
(Hydrolase_4)
5 ALA A 192
ALA A 196
LEU A 198
LEU A 104
ALA A 108
None
1.07A 2bxeA-2xuaA:
undetectable
2bxeA-2xuaA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA


(Escherichia
coli)
PF13580
(SIS_2)
5 ALA A 115
LEU A 182
ALA A  30
LEU A 113
VAL A 112
None
1.17A 2bxeA-2yvaA:
undetectable
2bxeA-2yvaA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywg GTP-BINDING PROTEIN
LEPA


(Aquifex
aeolicus)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C)
5 PHE A 118
LEU A 439
GLU A 447
LEU A 153
VAL A 152
None
1.23A 2bxeA-2ywgA:
undetectable
2bxeA-2ywgA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxg DIHYDRODIPICOLINATE
SYNTHASE


(Methanocaldococcus
jannaschii)
PF00701
(DHDPS)
5 ALA A 253
LEU A 279
ALA A 240
SER A 202
VAL A 204
None
1.14A 2bxeA-2yxgA:
undetectable
2bxeA-2yxgA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ady DOTD

(Legionella
pneumophila)
PF16816
(DotD)
5 ALA A  99
ALA A 101
LEU A  41
LEU A 128
ALA A  83
None
1.03A 2bxeA-3adyA:
undetectable
2bxeA-3adyA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale)
PF00232
(Glyco_hydro_1)
5 LEU A 322
LEU A 236
ALA A 239
GLU A 243
VAL A 165
None
0.99A 2bxeA-3aivA:
undetectable
2bxeA-3aivA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense)
PF00326
(Peptidase_S9)
5 ALA A 639
LEU A 658
LEU A 586
ALA A 616
LEU A 533
None
0.93A 2bxeA-3azqA:
undetectable
2bxeA-3azqA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0h NITRITE REDUCTASE

(Nicotiana
tabacum)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
5 ALA A 278
LEU A 335
GLU A 320
LEU A 260
VAL A 261
None
1.10A 2bxeA-3b0hA:
undetectable
2bxeA-3b0hA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7j TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY


(Pseudomonas
syringae group
genomosp. 3)
PF00392
(GntR)
PF07729
(FCD)
5 ALA A 122
ALA A 124
LEU A 151
LEU A 196
ALA A 199
None
1.09A 2bxeA-3c7jA:
undetectable
2bxeA-3c7jA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN


(Pyrococcus
furiosus)
PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB)
5 LEU A   6
LEU A  39
ALA A  38
LEU A  48
VAL A  49
None
1.25A 2bxeA-3dm5A:
3.8
2bxeA-3dm5A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN


(Pyrococcus
furiosus)
PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB)
5 LEU A  10
LEU A  39
ALA A  38
LEU A  48
VAL A  49
None
1.18A 2bxeA-3dm5A:
3.8
2bxeA-3dm5A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fse TWO-DOMAIN PROTEIN
CONTAINING
DJ-1/THIJ/PFPI-LIKE
AND FERRITIN-LIKE
DOMAINS


(Trichormus
variabilis)
PF01965
(DJ-1_PfpI)
PF09537
(DUF2383)
5 PHE A  73
LEU A 173
LEU A  32
ALA A  35
VAL A  39
None
0.66A 2bxeA-3fseA:
2.9
2bxeA-3fseA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE


(Thermus
thermophilus)
PF00398
(RrnaAD)
5 PHE A  51
ALA A  43
LEU A  64
ALA A  67
VAL A  71
None
1.16A 2bxeA-3futA:
undetectable
2bxeA-3futA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gor PUTATIVE
METAL-DEPENDENT
HYDROLASE


(Geobacillus
stearothermophilus)
PF05163
(DinB)
5 ALA A  41
ALA A  45
LEU A  49
LEU A  78
ALA A  82
None
1.17A 2bxeA-3gorA:
2.3
2bxeA-3gorA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqp HEMOGLOBIN SUBUNIT
ALPHA


(Felis catus)
PF00042
(Globin)
5 ALA A  69
LEU A  76
SER A  84
LEU A 136
VAL A 135
None
None
None
HEM  A 143 (-4.9A)
None
0.99A 2bxeA-3gqpA:
undetectable
2bxeA-3gqpA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1


(Streptomyces
antibioticus)
PF16670
(PI-PLC-C1)
5 ALA A 315
LEU A 312
LEU A 267
ALA A 263
SER A 270
None
1.04A 2bxeA-3h4xA:
undetectable
2bxeA-3h4xA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h75 PERIPLASMIC
SUGAR-BINDING DOMAIN
PROTEIN


(Pseudomonas
protegens)
PF13407
(Peripla_BP_4)
5 ALA A 253
ALA A 256
LEU A 236
SER A 292
LEU A 291
None
1.16A 2bxeA-3h75A:
undetectable
2bxeA-3h75A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl6 PATHOGENICITY ISLAND
PROTEIN


(Staphylococcus
aureus)
PF16560
(SAPI)
5 LEU A  79
LEU A  53
ALA A  71
SER A  28
LEU A  24
None
1.17A 2bxeA-3hl6A:
undetectable
2bxeA-3hl6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C)
5 ALA A 924
LEU A 926
LEU A 908
LEU A 916
VAL A 913
None
1.20A 2bxeA-3hmjA:
undetectable
2bxeA-3hmjA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
5 LEU A 260
ALA A 420
GLU A 480
SER A 346
LEU A 345
None
1.15A 2bxeA-3ihvA:
undetectable
2bxeA-3ihvA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdn RIBULOSE
BISPHOSPHATE
CARBOXYLASE


(Thermococcus
kodakarensis)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 ALA A 109
LEU A 123
ALA A  27
LEU A 301
VAL A 300
None
1.17A 2bxeA-3kdnA:
undetectable
2bxeA-3kdnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knz PUTATIVE SUGAR
BINDING PROTEIN


(Salmonella
enterica)
PF01380
(SIS)
5 ALA A  25
ALA A  22
LEU A 153
LEU A  81
VAL A  31
None
1.25A 2bxeA-3knzA:
undetectable
2bxeA-3knzA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvt 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE SYNTHASE


(Listeria
monocytogenes)
PF00793
(DAHP_synth_1)
PF01817
(CM_2)
5 ALA A 209
LEU A 218
ALA A 244
SER A 235
LEU A 234
None
1.25A 2bxeA-3nvtA:
3.3
2bxeA-3nvtA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot4 PUTATIVE
ISOCHORISMATASE


(Bordetella
bronchiseptica)
PF00857
(Isochorismatase)
5 ALA A  16
ALA A 193
LEU A 166
LEU A  19
GLU A 199
None
1.24A 2bxeA-3ot4A:
undetectable
2bxeA-3ot4A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p39 NONSTRUCTURAL
PROTEIN 1


(Influenza A
virus)
PF00600
(Flu_NS1)
5 ALA A 172
LEU A 125
LEU A 142
ALA A 144
LEU A 110
None
1.19A 2bxeA-3p39A:
undetectable
2bxeA-3p39A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN


(Homo sapiens)
PF04389
(Peptidase_M28)
5 ALA X 373
LEU X  88
LEU X 197
ALA X 200
GLU X 204
None
1.17A 2bxeA-3pb9X:
undetectable
2bxeA-3pb9X:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pft FLAVIN REDUCTASE

(Mycolicibacterium
goodii)
PF01613
(Flavin_Reduct)
5 ALA A  26
ALA A  24
LEU A  76
LEU A  87
ALA A  83
None
1.18A 2bxeA-3pftA:
undetectable
2bxeA-3pftA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q10 PANTOATE--BETA-ALANI
NE LIGASE


(Yersinia pestis)
PF02569
(Pantoate_ligase)
5 ALA A 201
LEU A 193
LEU A 269
ALA A 272
LEU A 233
None
1.24A 2bxeA-3q10A:
undetectable
2bxeA-3q10A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7a PHOSPHOGLYCERATE
MUTASE, PUTATIVE


(Bacillus
anthracis)
PF00300
(His_Phos_1)
5 ALA A  68
ALA A  72
LEU A  76
LEU A  86
ALA A  60
None
1.00A 2bxeA-3r7aA:
undetectable
2bxeA-3r7aA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfb PUTATIVE
UNCHARACTERIZED
PROTEIN


(Streptococcus
pneumoniae)
PF13185
(GAF_2)
5 ALA A  34
LEU A 127
LEU A 125
LEU A 150
VAL A 147
None
1.17A 2bxeA-3rfbA:
undetectable
2bxeA-3rfbA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1


(Mus musculus)
PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40)
5 ALA A 164
ALA A 167
LEU A 173
LEU A 140
VAL A 150
None
1.17A 2bxeA-3sfzA:
undetectable
2bxeA-3sfzA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqz PUTATIVE
HYDROXYMETHYLGLUTARY
L-COA SYNTHASE


(Streptococcus
mutans)
PF00195
(Chal_sti_synt_N)
PF08540
(HMG_CoA_synt_C)
5 ALA A  55
ALA A  59
LEU A  63
LEU A 134
LEU A  76
None
1.23A 2bxeA-3sqzA:
undetectable
2bxeA-3sqzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens)
PF13516
(LRR_6)
5 ALA A 847
LEU A 883
LEU A 870
ALA A 856
VAL A 842
None
1.25A 2bxeA-3un9A:
2.8
2bxeA-3un9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN


(Burkholderia
thailandensis)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
5 ALA A 279
ALA A 321
LEU A 316
LEU A 273
VAL A 272
None
1.24A 2bxeA-3uw2A:
undetectable
2bxeA-3uw2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7i PUTATIVE POLYKETIDE
SYNTHASE


(Streptomyces
coelicolor)
PF00195
(Chal_sti_synt_N)
5 ALA A 370
LEU A 310
ALA A 359
LEU A 389
VAL A 243
None
0.87A 2bxeA-3v7iA:
undetectable
2bxeA-3v7iA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vly NITRITE REDUCTASE

(Nicotiana
tabacum)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
5 ALA A 278
LEU A 335
GLU A 320
LEU A 260
VAL A 261
None
1.06A 2bxeA-3vlyA:
undetectable
2bxeA-3vlyA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
ALPHA


(Mammuthus
primigenius)
PF00042
(Globin)
5 ALA A  69
LEU A  76
SER A  84
LEU A 136
VAL A 135
None
1.14A 2bxeA-3vreA:
2.0
2bxeA-3vreA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE


(Methanosarcina
mazei)
PF01208
(URO-D)
5 ALA A 182
ALA A 185
LEU A 118
LEU A  81
ALA A  84
None
0.65A 2bxeA-4ay7A:
undetectable
2bxeA-4ay7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2q ATP SYNTHASE SUBUNIT
DELTA, MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF02823
(ATP-synt_DE_N)
5 ALA H  87
LEU H  16
ALA H  90
LEU H  32
VAL H  57
None
1.07A 2bxeA-4b2qH:
undetectable
2bxeA-4b2qH:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE


(Burkholderia
pseudomallei)
PF00155
(Aminotran_1_2)
5 ALA A 113
LEU A 277
LEU A 260
ALA A 100
LEU A 109
None
0.99A 2bxeA-4effA:
undetectable
2bxeA-4effA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0l AMIDOHYDROLASE

(Brucella
abortus)
PF01979
(Amidohydro_1)
5 ALA A 149
ALA A 147
LEU A 199
LEU A 157
ALA A 205
None
1.06A 2bxeA-4f0lA:
undetectable
2bxeA-4f0lA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f8x ENDO-1,4-BETA-XYLANA
SE


(Penicillium
canescens)
PF00331
(Glyco_hydro_10)
5 PHE A 180
ALA A 183
ALA A 187
LEU A 191
LEU A 201
None
1.19A 2bxeA-4f8xA:
undetectable
2bxeA-4f8xA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae)
PF00275
(EPSP_synthase)
5 ALA A  45
ALA A  43
LEU A 228
LEU A 201
ALA A 204
None
0.92A 2bxeA-4fqdA:
undetectable
2bxeA-4fqdA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae)
PF00275
(EPSP_synthase)
5 ALA A  45
LEU A 228
LEU A 201
ALA A 204
LEU A 111
None
1.04A 2bxeA-4fqdA:
undetectable
2bxeA-4fqdA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3n DNA GYRASE SUBUNIT A

(Mycobacterium
tuberculosis)
PF03989
(DNA_gyraseA_C)
5 ALA A 732
LEU A 803
ALA A 776
LEU A 762
VAL A 763
None
1.13A 2bxeA-4g3nA:
undetectable
2bxeA-4g3nA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE


(Streptomyces
lydicus)
PF00501
(AMP-binding)
PF03621
(MbtH)
5 ALA A 341
ALA A 343
LEU A 352
ALA A 328
VAL A 370
None
1.20A 2bxeA-4gr4A:
undetectable
2bxeA-4gr4A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr5 NON-RIBOSOMAL
PEPTIDE SYNTHETASE


(Streptomyces
lydicus)
PF00501
(AMP-binding)
PF03621
(MbtH)
5 ALA A 341
ALA A 343
LEU A 352
ALA A 328
VAL A 370
None
1.13A 2bxeA-4gr5A:
undetectable
2bxeA-4gr5A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12


(Thermus
thermophilus)
PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N)
5 PHE L 323
ALA L 326
ALA L 330
LEU L 334
LEU L 449
None
1.19A 2bxeA-4heaL:
undetectable
2bxeA-4heaL:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpp PROBABLE GLUTAMINE
SYNTHETASE


(Pseudomonas
aeruginosa)
PF00120
(Gln-synt_C)
PF16952
(Gln-synt_N_2)
5 ALA A 345
ALA A 348
LEU A 404
LEU A 277
ALA A 276
None
0.80A 2bxeA-4hppA:
undetectable
2bxeA-4hppA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN


(Pseudomonas)
PF01804
(Penicil_amidase)
5 ALA B 402
ALA B 406
LEU B 410
LEU B 315
ALA B 335
None
1.10A 2bxeA-4hstB:
undetectable
2bxeA-4hstB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib2 PUTATIVE LIPOPROTEIN

([Ruminococcus]
gnavus)
PF03180
(Lipoprotein_9)
5 PHE A  86
LEU A 257
LEU A  52
ALA A  55
VAL A  68
None
0.90A 2bxeA-4ib2A:
undetectable
2bxeA-4ib2A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Alicyclobacillus
acidocaldarius)
PF13416
(SBP_bac_8)
5 ALA A 389
ALA A 385
LEU A 381
LEU A 302
ALA A 163
None
1.00A 2bxeA-4ovjA:
undetectable
2bxeA-4ovjA:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
8 PHE A 206
ALA A 210
ALA A 213
LEU A 331
LEU A 347
SER A 480
LEU A 481
VAL A 482
None
None
NPS  A 602 (-3.3A)
None
NPS  A 602 ( 4.2A)
None
None
None
0.59A 2bxeA-4po0A:
45.5
2bxeA-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
8 PHE A 206
ALA A 213
LEU A 331
LEU A 347
GLU A 354
SER A 480
LEU A 481
VAL A 482
None
NPS  A 602 (-3.3A)
None
NPS  A 602 ( 4.2A)
NPS  A 602 ( 4.9A)
None
None
None
0.62A 2bxeA-4po0A:
45.5
2bxeA-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B


(Saccharomyces
cerevisiae)
PF08662
(eIF2A)
5 PHE A 342
ALA A 381
LEU A 334
ALA A 331
VAL A 319
None
1.15A 2bxeA-4u1fA:
undetectable
2bxeA-4u1fA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3B

(Lachancea
kluyveri)
PF00318
(Ribosomal_S2)
5 PHE b 408
ALA b 447
LEU b 400
ALA b 397
VAL b 385
None
1.16A 2bxeA-4uerb:
undetectable
2bxeA-4uerb:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
9 PHE A 205
ALA A 209
ALA A 212
LEU A 330
LEU A 346
ALA A 349
GLU A 353
SER A 479
LEU A 480
None
CZE  A 613 ( 4.4A)
CZE  A 613 ( 3.7A)
CZE  A 613 ( 4.2A)
CZE  A 613 ( 3.8A)
CZE  A 613 ( 4.7A)
CZE  A 613 (-2.9A)
None
None
0.64A 2bxeA-5dqfA:
46.1
2bxeA-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48


(Mycolicibacterium
smegmatis)
PF00004
(AAA)
PF02359
(CDC48_N)
5 LEU A 639
LEU A 610
ALA A 591
LEU A 570
VAL A 567
None
1.10A 2bxeA-5e7pA:
2.4
2bxeA-5e7pA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed7 TEGUMENT PROTEIN
UL21


(Human
alphaherpesvirus
1)
PF03252
(Herpes_UL21)
5 ALA A 401
ALA A 404
LEU A 459
LEU A 435
VAL A 520
None
1.00A 2bxeA-5ed7A:
2.5
2bxeA-5ed7A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE


(Corynebacterium
glutamicum)
PF01113
(DapB_N)
PF05173
(DapB_C)
5 LEU A 102
LEU A 242
ALA A 104
LEU A 113
VAL A 112
None
1.24A 2bxeA-5eesA:
undetectable
2bxeA-5eesA:
18.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
10 PHE A 206
ALA A 210
ALA A 213
LEU A 331
LEU A 347
ALA A 350
GLU A 354
SER A 480
LEU A 481
VAL A 482
None
0.69A 2bxeA-5ghkA:
45.7
2bxeA-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus)
PF07859
(Abhydrolase_3)
5 ALA A  85
ALA A 157
LEU A 161
ALA A 125
LEU A  88
None
0.80A 2bxeA-5l2pA:
undetectable
2bxeA-5l2pA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n3u PHYCOCYANOBILIN
LYASE SUBUNIT ALPHA


(Nostoc sp. PCC
7120)
no annotation 5 ALA A  38
LEU A  26
LEU A  55
ALA A  58
SER A 111
None
1.09A 2bxeA-5n3uA:
undetectable
2bxeA-5n3uA:
9.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 9 PHE A 205
ALA A 209
ALA A 212
LEU A 330
LEU A 346
ALA A 349
GLU A 353
SER A 479
LEU A 480
None
0.45A 2bxeA-5oriA:
45.7
2bxeA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 9 PHE A 205
ALA A 209
ALA A 212
LEU A 330
LEU A 346
ALA A 349
SER A 479
LEU A 480
VAL A 481
None
0.49A 2bxeA-5oriA:
45.7
2bxeA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)


(Corynebacterium
freiburgense)
PF00171
(Aldedh)
PF01619
(Pro_dh)
5 ALA A 625
ALA A 628
LEU A 529
ALA A 558
GLU A 554
None
0.63A 2bxeA-5ux5A:
undetectable
2bxeA-5ux5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)


(Corynebacterium
freiburgense)
PF00171
(Aldedh)
PF01619
(Pro_dh)
5 ALA A 625
ALA A 628
LEU A 529
LEU A 600
ALA A 558
None
0.71A 2bxeA-5ux5A:
undetectable
2bxeA-5ux5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE


(Sinorhizobium
meliloti)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 ALA A 251
LEU A 243
LEU A 239
SER A 232
VAL A 234
None
1.15A 2bxeA-5v72A:
undetectable
2bxeA-5v72A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpz FERMITIN FAMILY
HOMOLOG 2


(Mus musculus)
PF00373
(FERM_M)
5 ALA A  86
ALA A  88
LEU A  90
LEU A  20
VAL A  35
None
0.95A 2bxeA-5xpzA:
3.1
2bxeA-5xpzA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE


(Pyrococcus
horikoshii)
no annotation 5 PHE A 106
ALA A  32
ALA A  34
LEU A  61
ALA A  13
None
1.15A 2bxeA-5yg7A:
2.5
2bxeA-5yg7A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 9 PHE A 206
ALA A 210
ALA A 213
LEU A 331
LEU A 347
ALA A 350
GLU A 354
LEU A 481
VAL A 482
None
0.48A 2bxeA-5yxeA:
46.6
2bxeA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 8 PHE A 206
LEU A 331
LEU A 347
ALA A 350
GLU A 354
SER A 480
LEU A 481
VAL A 482
None
0.56A 2bxeA-5yxeA:
46.6
2bxeA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT C'


(Saccharomyces
cerevisiae)
no annotation 5 PHE D  18
ALA D  21
ALA D  25
LEU D  29
LEU D 103
None
1.19A 2bxeA-6c6lD:
undetectable
2bxeA-6c6lD:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G


(Pyrococcus
furiosus)
no annotation 5 ALA C  98
ALA C  95
LEU A 123
LEU C  35
VAL B  32
None
1.24A 2bxeA-6cfwC:
3.8
2bxeA-6cfwC:
7.86