SIMILAR PATTERNS OF AMINO ACIDS FOR 2BXE_A_1FLA2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0j TRYPSIN

(Salmo salar)
PF00089
(Trypsin)
5 LEU A 163
ILE A 162
VAL A 199
GLY A 211
LEU A 160
None
0.98A 2bxeA-1a0jA:
undetectable
2bxeA-1a0jA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a70 FERREDOXIN

(Spinacia
oleracea)
PF00111
(Fer2)
5 ILE A  24
VAL A  74
GLY A  49
LEU A  56
SER A  83
None
1.30A 2bxeA-1a70A:
undetectable
2bxeA-1a70A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atg PERIPLASMIC
MOLYBDATE-BINDING
PROTEIN


(Azotobacter
vinelandii)
PF13531
(SBP_bac_11)
5 LEU A 161
ILE A 108
VAL A 125
GLY A 122
LEU A 100
None
1.27A 2bxeA-1atgA:
undetectable
2bxeA-1atgA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg8 PROTEIN (HEMOGLOBIN)

(Dasyatis akajei)
PF00042
(Globin)
5 LEU A  16
ILE A  17
ASN A  20
GLY A  25
LEU A 110
None
1.08A 2bxeA-1cg8A:
2.0
2bxeA-1cg8A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN


(Escherichia
coli)
PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
5 ILE A  93
VAL A 175
GLY A 176
CYH A 123
LEU A   3
None
1.09A 2bxeA-1cqjA:
undetectable
2bxeA-1cqjA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I


(Proteus
vulgaris)
PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt)
5 LEU A 519
ILE A 520
GLY A 531
LEU A 481
SER A 450
None
1.40A 2bxeA-1hn0A:
2.7
2bxeA-1hn0A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE


(Thermus
thermophilus)
PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind)
5 ARG A  20
VAL A 147
GLY A 149
LEU A 130
SER A 155
None
1.36A 2bxeA-1ipaA:
undetectable
2bxeA-1ipaA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis)
PF07992
(Pyr_redox_2)
5 ARG A  96
TYR A  97
VAL A  84
GLY A  85
LEU A  39
None
None
FAD  A2457 (-3.6A)
FAD  A2457 ( 4.7A)
None
1.25A 2bxeA-1lqtA:
undetectable
2bxeA-1lqtA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE


(Bacillus
subtilis)
PF00171
(Aldedh)
5 LEU A 191
VAL A 105
GLY A 108
CYH A 160
LEU A  86
None
1.27A 2bxeA-1t90A:
0.0
2bxeA-1t90A:
22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
5 ILE A 388
ASN A 391
ARG A 410
LYS A 414
GLY A 434
None
1.16A 2bxeA-1tf0A:
47.5
2bxeA-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
8 LEU A 387
ILE A 388
ASN A 391
TYR A 411
LYS A 414
GLY A 434
LEU A 453
SER A 489
None
0.78A 2bxeA-1tf0A:
47.5
2bxeA-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
8 LEU A 387
ILE A 388
TYR A 411
LYS A 414
VAL A 433
GLY A 434
LEU A 453
SER A 489
None
0.78A 2bxeA-1tf0A:
47.5
2bxeA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wck BCLA PROTEIN

(Bacillus
anthracis)
PF01391
(Collagen)
5 LEU A 167
ILE A 174
VAL A 105
LEU A 200
SER A 146
None
1.22A 2bxeA-1wckA:
undetectable
2bxeA-1wckA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjv PROTECTION OF
TELOMERES 1


(Homo sapiens)
PF02765
(POT1)
PF16686
(POT1PC)
5 LEU A 239
ILE A 241
VAL A 222
LEU A 181
SER A 237
None
1.31A 2bxeA-1xjvA:
undetectable
2bxeA-1xjvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8t HYPOTHETICAL PROTEIN
RV0983


(Mycobacterium
tuberculosis)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
5 ILE A 216
VAL A  91
GLY A  82
LEU A  45
SER A 185
None
1.38A 2bxeA-1y8tA:
undetectable
2bxeA-1y8tA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeh FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF00373
(FERM_M)
5 LEU A 223
ILE A 224
GLY A 172
CYH A 173
LEU A 211
None
1.34A 2bxeA-2aehA:
undetectable
2bxeA-2aehA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4v RNA EDITING COMPLEX
PROTEIN MP57


(Trypanosoma
brucei)
PF01909
(NTP_transf_2)
PF03828
(PAP_assoc)
5 LEU A 280
ILE A 281
ASN A 277
VAL A  87
GLY A  84
None
1.34A 2bxeA-2b4vA:
undetectable
2bxeA-2b4vA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cje DUTPASE

(Leishmania
major)
PF08761
(dUTPase_2)
5 LEU A 209
ASN A 206
ARG A 186
TYR A 196
VAL A 203
None
DUN  A1266 (-3.7A)
DUN  A1266 (-3.0A)
None
None
1.16A 2bxeA-2cjeA:
undetectable
2bxeA-2cjeA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eek TRYPSIN-1

(Gadus morhua)
PF00089
(Trypsin)
5 LEU A 163
ILE A 162
VAL A 199
GLY A 211
LEU A 160
None
0.99A 2bxeA-2eekA:
undetectable
2bxeA-2eekA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B


(Homo sapiens)
PF14580
(LRR_9)
5 LEU A  67
ILE A  41
VAL A  59
GLY A  60
LEU A  56
None
1.27A 2bxeA-2ellA:
undetectable
2bxeA-2ellA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4w UBIQUITIN-CONJUGATIN
G ENZYME E2, J2


(Homo sapiens)
PF00179
(UQ_con)
5 LEU A  93
ILE A  78
ARG A  86
TYR A  56
GLY A 117
None
1.31A 2bxeA-2f4wA:
undetectable
2bxeA-2f4wA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i15 HYPOTHETICAL PROTEIN
MG296 HOMOLOG


(Mycoplasma
pneumoniae)
PF09644
(Mg296)
5 LEU A  97
ILE A 101
VAL A 125
GLY A 120
SER A  65
None
1.16A 2bxeA-2i15A:
undetectable
2bxeA-2i15A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF00373
(FERM_M)
PF07714
(Pkinase_Tyr)
5 LEU A 223
ILE A 224
GLY A 172
CYH A 173
LEU A 211
None
1.34A 2bxeA-2j0jA:
undetectable
2bxeA-2j0jA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l5o PUTATIVE THIOREDOXIN

(Neisseria
meningitidis)
PF08534
(Redoxin)
5 LEU A  62
ILE A  30
VAL A  95
GLY A  96
LEU A  10
None
1.31A 2bxeA-2l5oA:
undetectable
2bxeA-2l5oA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 LEU A 128
ILE A 129
VAL A 139
LEU A  72
SER A 101
None
1.23A 2bxeA-2p6rA:
undetectable
2bxeA-2p6rA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA


(Saccharomyces
cerevisiae)
PF00698
(Acyl_transf_1)
PF16073
(SAT)
5 LEU B 443
ILE B 439
VAL B 308
GLY B 307
CYH B 310
None
1.26A 2bxeA-2pffB:
undetectable
2bxeA-2pffB:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE


(Arabidopsis
thaliana)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 LEU A  36
ILE A  32
VAL A 109
CYH A  89
LEU A 340
None
1.41A 2bxeA-2q49A:
undetectable
2bxeA-2q49A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8w AGR_C_1641P

(Agrobacterium
fabrum)
PF00701
(DHDPS)
5 LEU A 184
ILE A 190
VAL A 155
GLY A 157
LEU A 135
None
1.30A 2bxeA-2r8wA:
undetectable
2bxeA-2r8wA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN


(Staphylococcus
haemolyticus)
PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5)
5 ILE B 620
VAL B 628
GLY B 627
LEU B 515
SER A 105
None
1.16A 2bxeA-2rhqB:
undetectable
2bxeA-2rhqB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdv MYC-INDUCED NUCLEAR
ANTIGEN


(Homo sapiens)
PF08007
(Cupin_4)
5 LEU A  33
ILE A 150
ARG A  68
VAL A 254
LEU A  80
None
1.16A 2bxeA-2xdvA:
undetectable
2bxeA-2xdvA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt0 HALOALKANE
DEHALOGENASE


(Plesiocystis
pacifica)
PF00561
(Abhydrolase_1)
5 ILE A 213
ARG A 103
GLY A 222
LEU A 128
SER A 104
None
None
SO4  A1298 (-3.0A)
None
None
1.36A 2bxeA-2xt0A:
undetectable
2bxeA-2xt0A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1


(Homo sapiens)
PF10613
(Lig_chan-Glu_bd)
5 LEU A 770
ILE A 767
VAL A 751
GLY A 750
LEU A 456
None
1.20A 2bxeA-2znsA:
undetectable
2bxeA-2znsA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab0 BCLA PROTEIN

(Bacillus
anthracis)
no annotation 5 LEU A 167
ILE A 174
VAL A 105
LEU A 200
SER A 146
None
1.34A 2bxeA-3ab0A:
undetectable
2bxeA-3ab0A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Mus musculus)
PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD)
5 LEU A 598
ASN A 696
VAL A 658
GLY A 657
CYH A 662
None
None
None
None
ZN  A2002 (-2.1A)
1.33A 2bxeA-3av6A:
undetectable
2bxeA-3av6A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1


(Homo sapiens)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2)
5 LEU A 235
ILE A 263
VAL A 247
LEU A 211
SER A 224
None
1.36A 2bxeA-3ctzA:
undetectable
2bxeA-3ctzA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbs OXIDOREDUCTASE

(Agrobacterium
fabrum)
PF07992
(Pyr_redox_2)
5 ILE A 105
ARG A 289
GLY A 280
CYH A 263
LEU A  21
None
1.37A 2bxeA-3fbsA:
undetectable
2bxeA-3fbsA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2


(Schizosaccharomyces
pombe)
PF03159
(XRN_N)
5 ILE A 394
TYR A 617
VAL A 387
GLY A 388
LEU A 344
None
1.39A 2bxeA-3fqdA:
undetectable
2bxeA-3fqdA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A


(Aquifex
aeolicus)
PF01425
(Amidase)
5 LEU A  89
ILE A  88
VAL A 348
GLY A 345
LEU A 314
None
1.27A 2bxeA-3h0lA:
undetectable
2bxeA-3h0lA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus)
PF08337
(Plexin_cytopl)
5 LEU A1391
ILE A1392
ASN A1395
LEU A1406
SER A1411
None
1.18A 2bxeA-3ig3A:
undetectable
2bxeA-3ig3A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT


(Mycobacterium
marinum)
PF00797
(Acetyltransf_2)
5 LEU A 266
ILE A 270
GLY A 223
CYH A 274
LEU A 249
None
1.14A 2bxeA-3ltwA:
undetectable
2bxeA-3ltwA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE


(Clostridioides
difficile)
PF06050
(HGD-D)
5 ILE B  43
VAL B  51
GLY B  52
CYH B  33
LEU B  49
None
1.28A 2bxeA-3o3mB:
undetectable
2bxeA-3o3mB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o59 DNA POLYMERASE II
LARGE SUBUNIT


(Pyrococcus
horikoshii)
PF03833
(PolC_DP2)
5 ILE X 125
VAL X 164
GLY X 165
LEU X 110
SER X 153
None
1.05A 2bxeA-3o59X:
2.1
2bxeA-3o59X:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovg AMIDOHYDROLASE

(Mycoplasma
synoviae)
PF02126
(PTE)
5 LEU A 258
TYR A 223
VAL A 233
GLY A 232
LEU A 235
None
1.41A 2bxeA-3ovgA:
undetectable
2bxeA-3ovgA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3


(Pseudomonas
putida)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
5 LEU A  23
ILE A  20
VAL A 239
GLY A 240
LEU A 267
None
1.37A 2bxeA-3pwzA:
undetectable
2bxeA-3pwzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxi NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB


(Bacillus
subtilis)
PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small)
5 LEU A 725
ILE A 722
ARG A 556
VAL A 549
GLY A 548
None
1.11A 2bxeA-3pxiA:
undetectable
2bxeA-3pxiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhp TYPE 1 CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
J (CAPJ)


(Helicobacter
pylori)
PF00534
(Glycos_transf_1)
5 ILE A 289
VAL A 208
GLY A 209
LEU A 268
SER A 296
None
1.29A 2bxeA-3qhpA:
undetectable
2bxeA-3qhpA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2


(Homo sapiens)
PF10613
(Lig_chan-Glu_bd)
5 LEU A 754
ILE A 751
VAL A 735
GLY A 734
LEU A 439
None
1.15A 2bxeA-3qxmA:
undetectable
2bxeA-3qxmA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I


(Burkholderia
lata)
PF00117
(GATase)
PF00425
(Chorismate_bind)
5 ILE A 516
VAL A 580
GLY A 584
LEU A 536
SER A 607
None
1.18A 2bxeA-3r75A:
undetectable
2bxeA-3r75A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I


(Burkholderia
lata)
PF00117
(GATase)
PF00425
(Chorismate_bind)
5 LEU A 512
ILE A 516
VAL A 586
GLY A 602
LEU A 536
None
1.14A 2bxeA-3r75A:
undetectable
2bxeA-3r75A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8e HYPOTHETICAL SUGAR
KINASE


(Cytophaga
hutchinsonii)
PF00480
(ROK)
5 LEU A 233
ILE A 236
VAL A 141
GLY A 140
LEU A 242
None
1.21A 2bxeA-3r8eA:
undetectable
2bxeA-3r8eA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE


(Ralstonia
pickettii)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 LEU A 182
ILE A 208
ARG A 166
VAL A 188
LEU A 196
None
1.35A 2bxeA-3rr1A:
undetectable
2bxeA-3rr1A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryt PLEXIN-A1

(Mus musculus)
PF08337
(Plexin_cytopl)
5 LEU A1413
ILE A1414
ASN A1417
LEU A1428
SER A1433
None
0.98A 2bxeA-3rytA:
undetectable
2bxeA-3rytA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT


(uncultured
archaeon)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
5 LEU B  47
ILE B  75
VAL B 155
GLY B 154
LEU B 133
None
1.31A 2bxeA-3sqgB:
undetectable
2bxeA-3sqgB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE


(Leishmania
donovani)
PF00291
(PALP)
5 LEU A 244
ILE A 245
VAL A 185
GLY A 184
LEU A 240
None
None
LLP  A  51 ( 4.2A)
None
None
1.16A 2bxeA-3tbhA:
undetectable
2bxeA-3tbhA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A


(Coxiella
burnetii)
PF00398
(RrnaAD)
5 LEU A  21
ILE A  24
LYS A  73
VAL A 104
GLY A 105
None
1.21A 2bxeA-3tqsA:
undetectable
2bxeA-3tqsA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A


(Coxiella
burnetii)
PF00398
(RrnaAD)
5 LEU A  21
ILE A  24
VAL A 104
GLY A 105
LEU A  50
None
1.18A 2bxeA-3tqsA:
undetectable
2bxeA-3tqsA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tyj BCLA PROTEIN

(Bacillus
anthracis)
no annotation 5 LEU A 167
ILE A 174
VAL A 105
LEU A 200
SER A 146
None
1.21A 2bxeA-3tyjA:
undetectable
2bxeA-3tyjA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbj GALACTOSIDE
O-ACETYLTRANSFERASE


(Bacillus cereus)
PF00132
(Hexapep)
5 LEU A  23
ASN A  21
VAL A  18
GLY A  19
LEU A  10
None
1.26A 2bxeA-3vbjA:
undetectable
2bxeA-3vbjA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ast ALDO-KETO REDUCTASE
AKR14A1


(Escherichia
coli)
PF00248
(Aldo_ket_red)
5 TYR A 170
VAL A 217
GLY A 218
CYH A  18
LEU A 189
None
1.08A 2bxeA-4astA:
undetectable
2bxeA-4astA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT


(Rhodopseudomonas
palustris)
PF13458
(Peripla_BP_6)
5 LEU A  49
ILE A  53
ASN A 130
TYR A 178
GLY A 105
None
None
PHB  A 406 (-3.7A)
PHB  A 406 ( 4.3A)
None
1.35A 2bxeA-4evqA:
undetectable
2bxeA-4evqA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io6 AVGLUR1 LIGAND
BINDING DOMAIN


(Adineta vaga)
PF00497
(SBP_bac_3)
5 LEU A 226
ILE A 225
ASN A 100
GLY A 208
LEU A 234
None
None
CL  A 303 (-3.1A)
None
None
1.41A 2bxeA-4io6A:
undetectable
2bxeA-4io6A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgg ESTERASE TESA

(Pseudomonas
aeruginosa)
PF13472
(Lipase_GDSL_2)
5 LEU A 107
ILE A 109
VAL A 146
GLY A 147
LEU A 168
None
1.41A 2bxeA-4jggA:
undetectable
2bxeA-4jggA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0q MEMBRANE-ASSOCIATED
PROTEIN VP24


(Zaire
ebolavirus)
PF06389
(Filo_VP24)
5 LEU A 152
ILE A 153
ASN A 156
GLY A 101
LEU A 119
None
1.11A 2bxeA-4m0qA:
undetectable
2bxeA-4m0qA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF01425
(Amidase)
5 LEU A  69
ILE A  68
VAL A 331
GLY A 328
LEU A 297
None
1.33A 2bxeA-4n0iA:
undetectable
2bxeA-4n0iA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o89 RNA 3'-TERMINAL
PHOSPHATE CYCLASE


(Pyrococcus
horikoshii)
PF01137
(RTC)
PF05189
(RTC_insert)
5 LEU A 132
ILE A 149
VAL A 168
GLY A 147
LEU A 103
None
1.28A 2bxeA-4o89A:
undetectable
2bxeA-4o89A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obs ALPHA-L-IDURONIDASE

(Homo sapiens)
PF01229
(Glyco_hydro_39)
5 LEU A 353
VAL A  88
GLY A  51
LEU A  74
SER A  67
None
1.10A 2bxeA-4obsA:
undetectable
2bxeA-4obsA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN


([Ruminococcus]
gnavus)
no annotation 5 ILE E 164
ASN E 163
VAL E 156
GLY E 158
SER E 299
None
PLP  E 501 ( 4.4A)
None
PLP  E 501 ( 4.3A)
None
1.32A 2bxeA-4obuE:
undetectable
2bxeA-4obuE:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN


([Ruminococcus]
gnavus)
no annotation 5 LEU E 167
ILE E 164
ASN E 163
VAL E 156
GLY E 158
None
None
PLP  E 501 ( 4.4A)
None
PLP  E 501 ( 4.3A)
1.32A 2bxeA-4obuE:
undetectable
2bxeA-4obuE:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120)
no annotation 5 ILE A 389
VAL A 341
GLY A 340
LEU A 354
SER A 261
None
0.76A 2bxeA-4oj5A:
undetectable
2bxeA-4oj5A:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
8 LEU A 387
ASN A 391
ARG A 410
TYR A 411
VAL A 433
GLY A 434
LEU A 453
SER A 489
NPS  A 601 ( 4.7A)
NPS  A 601 (-4.3A)
NPS  A 601 (-4.5A)
NPS  A 601 (-4.3A)
None
None
NPS  A 601 (-4.7A)
NPS  A 601 (-3.1A)
0.60A 2bxeA-4po0A:
45.5
2bxeA-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
8 LEU A 387
ASN A 391
TYR A 411
LYS A 414
VAL A 433
GLY A 434
LEU A 453
SER A 489
NPS  A 601 ( 4.7A)
NPS  A 601 (-4.3A)
NPS  A 601 (-4.3A)
NPS  A 601 (-2.7A)
None
None
NPS  A 601 (-4.7A)
NPS  A 601 (-3.1A)
0.58A 2bxeA-4po0A:
45.5
2bxeA-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxd 2-DEHYDRO-3-DEOXY-D-
GLUCONATE/2-DEHYDRO-
3-DEOXY-PHOSPHOGLUCO
NATE ALDOLASE


(Picrophilus
torridus)
PF00701
(DHDPS)
5 LEU A 121
ILE A 120
VAL A  75
GLY A  76
SER A 154
None
0.95A 2bxeA-4uxdA:
undetectable
2bxeA-4uxdA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB


(Lactococcus
lactis)
PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C)
5 LEU A 110
ILE A 690
ASN A  15
VAL A 701
SER A 302
None
1.20A 2bxeA-4wd9A:
2.3
2bxeA-4wd9A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj7 MALCAVERNIN

(Homo sapiens)
no annotation 5 LEU A 155
ILE A 139
VAL A 216
GLY A 214
LEU A 115
None
1.41A 2bxeA-4wj7A:
undetectable
2bxeA-4wj7A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydi ENVELOPE
GLYCOPROTEIN GP160


(Human
immunodeficiency
virus 1)
PF00516
(GP120)
5 LEU G 342
ASN G 339
VAL G 333
LEU G 390
SER G 393
None
1.30A 2bxeA-4ydiG:
undetectable
2bxeA-4ydiG:
17.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
9 LEU A 386
ASN A 390
ARG A 409
TYR A 410
LYS A 413
VAL A 432
GLY A 433
LEU A 452
SER A 488
None
0.75A 2bxeA-5dqfA:
46.1
2bxeA-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt5 BETA-GLUCOSIDASE

(Exiguobacterium
antarcticum)
PF00232
(Glyco_hydro_1)
5 LEU A 194
ILE A 251
GLY A 215
CYH A 286
LEU A 218
None
1.33A 2bxeA-5dt5A:
undetectable
2bxeA-5dt5A:
21.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
9 LEU A 387
ASN A 391
ARG A 410
TYR A 411
LYS A 414
VAL A 433
GLY A 434
LEU A 453
SER A 489
None
0.52A 2bxeA-5ghkA:
45.7
2bxeA-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT


(Pyrococcus
abyssi)
PF03833
(PolC_DP2)
5 ILE A 122
VAL A 161
GLY A 162
LEU A 107
SER A 150
None
1.04A 2bxeA-5ijlA:
undetectable
2bxeA-5ijlA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1


(Saccharomyces
cerevisiae)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
5 LEU A 374
ILE A 370
VAL A 364
GLY A 365
LEU A 489
None
1.42A 2bxeA-5ip9A:
3.9
2bxeA-5ip9A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN


(Pseudomonas
syringae group
genomosp. 3)
no annotation 5 LEU A 206
ILE A 203
GLY A 124
CYH A 175
LEU A 101
None
1.08A 2bxeA-5iuwA:
undetectable
2bxeA-5iuwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE


(Paraburkholderia
xenovorans)
PF13561
(adh_short_C2)
5 LEU A  95
ILE A 145
ASN A  97
GLY A 175
LEU A 134
None
1.38A 2bxeA-5jc8A:
undetectable
2bxeA-5jc8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE


(Paraburkholderia
xenovorans)
PF13561
(adh_short_C2)
5 LEU A  95
ILE A 145
VAL A 178
GLY A 175
LEU A 134
None
1.27A 2bxeA-5jc8A:
undetectable
2bxeA-5jc8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jff PROBABLE ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FIC


(Escherichia
coli)
PF02661
(Fic)
5 LEU A 134
ILE A 131
ARG A  78
GLY A 142
LEU A  59
None
1.40A 2bxeA-5jffA:
undetectable
2bxeA-5jffA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzd ISOCHORISMATE
SYNTHASE ENTC


(Escherichia
coli)
PF00425
(Chorismate_bind)
5 ARG A 347
VAL A 149
GLY A 363
LEU A 304
SER A 195
ISC  A 401 (-3.5A)
None
ISC  A 401 (-3.3A)
ISC  A 401 ( 4.4A)
None
1.07A 2bxeA-5jzdA:
undetectable
2bxeA-5jzdA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5och -

(-)
no annotation 5 LEU B 274
ILE B 270
VAL B 219
GLY B 220
LEU B 148
None
1.38A 2bxeA-5ochB:
undetectable
2bxeA-5ochB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-)
no annotation 5 ARG A 283
VAL A 138
GLY A 137
LEU A 494
SER A 279
NSQ  A 709 (-3.3A)
None
None
MPD  A 705 ( 4.5A)
MPD  A 705 ( 3.9A)
1.14A 2bxeA-5ohsA:
undetectable
2bxeA-5ohsA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 8 ILE A 387
ARG A 409
TYR A 410
LYS A 413
VAL A 432
GLY A 433
LEU A 452
SER A 488
None
0.75A 2bxeA-5oriA:
45.7
2bxeA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 8 ILE A 387
ASN A 390
ARG A 409
TYR A 410
LYS A 413
GLY A 433
LEU A 452
SER A 488
None
0.74A 2bxeA-5oriA:
45.7
2bxeA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 8 LEU A 386
ILE A 387
ASN A 390
TYR A 410
LYS A 413
GLY A 433
LEU A 452
SER A 488
None
0.97A 2bxeA-5oriA:
45.7
2bxeA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 8 LEU A 386
ILE A 387
TYR A 410
LYS A 413
VAL A 432
GLY A 433
LEU A 452
SER A 488
None
0.99A 2bxeA-5oriA:
45.7
2bxeA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2o J30 CCH

(Thermobacillus
composti)
no annotation 5 LEU A  95
VAL A 100
GLY A  99
CYH A 114
LEU A 184
None
None
None
ZN  A 606 (-2.3A)
None
1.33A 2bxeA-5u2oA:
undetectable
2bxeA-5u2oA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE


(Homo sapiens)
PF00479
(G6PD_N)
PF02781
(G6PD_C)
5 ILE A 355
VAL A 499
GLY A 500
CYH A 232
LEU A 495
None
1.38A 2bxeA-5ukwA:
undetectable
2bxeA-5ukwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vey HISTONE H2B TYPE
1-J,HISTONE H2A TYPE
1-B/E


(Homo sapiens)
PF00125
(Histone)
PF16211
(Histone_H2A_C)
5 LEU A 140
ILE A  70
VAL A 132
GLY A 133
LEU A 123
None
1.33A 2bxeA-5veyA:
2.3
2bxeA-5veyA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vzt F-BOX ONLY PROTEIN
31


(Homo sapiens)
no annotation 5 LEU B 138
ILE B 194
VAL B 162
GLY B 171
LEU B 146
None
1.28A 2bxeA-5vztB:
undetectable
2bxeA-5vztB:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN


(Mus musculus;
Rattus
norvegicus)
PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd)
5 LEU A 787
ASN A 791
TYR A 616
VAL A 795
GLY A 794
None
1.19A 2bxeA-5welA:
undetectable
2bxeA-5welA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT


(Komagataella
phaffii)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
5 LEU A 375
ILE A 371
VAL A 365
GLY A 366
LEU A 490
None
1.41A 2bxeA-5xogA:
4.2
2bxeA-5xogA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 7 ASN A 391
ARG A 410
LYS A 414
VAL A 433
GLY A 434
LEU A 453
SER A 489
None
0.99A 2bxeA-5yxeA:
46.6
2bxeA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 8 LEU A 387
ASN A 391
TYR A 411
LYS A 414
VAL A 433
GLY A 434
LEU A 453
SER A 489
None
0.82A 2bxeA-5yxeA:
46.6
2bxeA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0d AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY


(Paraburkholderia
phymatum)
no annotation 5 LEU A  20
ILE A  98
ARG A  43
VAL A 120
GLY A  79
None
1.39A 2bxeA-6c0dA:
undetectable
2bxeA-6c0dA:
9.12