SIMILAR PATTERNS OF AMINO ACIDS FOR 2BXC_A_P1ZA2001_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dcn | DELTA 2 CRYSTALLIN (Anasplatyrhynchos) |
PF00206(Lyase_1)PF14698(ASL_C2) | 5 | LEU A 273LEU A 275ALA A 348ILE A 352ALA A 259 | None | 1.06A | 2bxcA-1dcnA:2.1 | 2bxcA-1dcnA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g8x | MYOSIN II HEAVYCHAIN FUSED TOALPHA-ACTININ 3 (Dictyosteliumdiscoideum) |
PF00063(Myosin_head)PF00435(Spectrin)PF02736(Myosin_N) | 5 | LEU A 307LEU A 285ILE A 280ILE A 348ALA A 349 | None | 1.08A | 2bxcA-1g8xA:undetectable | 2bxcA-1g8xA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hwu | PII PROTEIN (Herbaspirillumseropedicae) |
PF00543(P-II) | 5 | LEU A 28LEU A 20ALA A 81ILE A 8ALA A 6 | None | 0.90A | 2bxcA-1hwuA:undetectable | 2bxcA-1hwuA:12.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iv8 | MALTOOLIGOSYLTREHALOSE SYNTHASE (Sulfolobusacidocaldarius) |
PF00128(Alpha-amylase)PF09196(DUF1953) | 6 | LEU A 343LEU A 380ALA A 369ILE A 366ILE A 334ALA A 329 | NoneNoneNoneNoneNoneMLZ A 326 ( 3.6A) | 1.14A | 2bxcA-1iv8A:0.0 | 2bxcA-1iv8A:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jx2 | MYOSIN-2 HEAVYCHAIN,DYNAMIN-A (Dictyosteliumdiscoideum) |
PF00063(Myosin_head)PF02736(Myosin_N) | 5 | LEU A 318LEU A 296ILE A 291ILE A 359ALA A 360 | None | 1.08A | 2bxcA-1jx2A:undetectable | 2bxcA-1jx2A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kkc | MANGANESE SUPEROXIDEDISMUTASE (Aspergillusfumigatus) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 6 | SER A 139GLN A 161LEU A 95HIS A 88ILE A 36ALA A 179 | None MN A2001 ( 4.8A)None MN A2001 (-3.4A)None MN A2001 ( 4.8A) | 1.13A | 2bxcA-1kkcA:undetectable | 2bxcA-1kkcA:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p0n | ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE (Bacillussubtilis) |
PF01070(FMN_dh) | 5 | SER A 257ALA A 141ILE A 139ILE A 119ALA A 90 | None | 1.06A | 2bxcA-1p0nA:undetectable | 2bxcA-1p0nA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pgj | 6-PHOSPHOGLUCONATEDEHYDROGENASE (Trypanosomabrucei) |
PF00393(6PGD)PF03446(NAD_binding_2) | 5 | LEU A 374ALA A 336ILE A 337ILE A 198ALA A 194 | None | 1.05A | 2bxcA-1pgjA:undetectable | 2bxcA-1pgjA:22.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tf0 | SERUM ALBUMIN (Homo sapiens) |
PF00273(Serum_albumin) | 5 | TYR A 150SER A 192GLN A 196HIS A 242ALA A 258 | DKA A1003 (-4.4A)NoneNoneDKA A1003 (-3.7A)None | 0.91A | 2bxcA-1tf0A:47.4 | 2bxcA-1tf0A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tf0 | SERUM ALBUMIN (Homo sapiens) |
PF00273(Serum_albumin) | 12 | TYR A 150SER A 192GLN A 196LYS A 199LEU A 219LEU A 238HIS A 242ARG A 257ALA A 261ILE A 264ILE A 290ALA A 291 | DKA A1003 (-4.4A)NoneNoneCIT A2001 ( 2.7A)NoneDKA A1003 (-4.3A)DKA A1003 (-3.7A)DKA A1003 (-4.1A)NoneNoneDKA A1003 ( 4.5A)CIT A2001 ( 3.9A) | 0.45A | 2bxcA-1tf0A:47.4 | 2bxcA-1tf0A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uqw | PUTATIVE BINDINGPROTEIN YLIB (Escherichiacoli) |
PF00496(SBP_bac_5) | 5 | LEU A 42ALA A 388ILE A 243ILE A 295ALA A 296 | NoneNoneNoneNoneGOL A 551 (-3.4A) | 0.94A | 2bxcA-1uqwA:undetectable | 2bxcA-1uqwA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w36 | EXODEOXYRIBONUCLEASEV GAMMA CHAIN (Escherichiacoli) |
PF04257(Exonuc_V_gamma) | 5 | LEU C 224LEU C 314ILE C 213ILE C 216ALA C 218 | None | 1.05A | 2bxcA-1w36C:undetectable | 2bxcA-1w36C:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bco | SUCCINYLGLUTAMATEDESUCCINYLASE (Vibrioparahaemolyticus) |
PF04952(AstE_AspA) | 5 | SER A 254LEU A 152ALA A 246ILE A 245ALA A 240 | None | 1.08A | 2bxcA-2bcoA:undetectable | 2bxcA-2bcoA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cdq | ASPARTOKINASE (Arabidopsisthaliana) |
PF00696(AA_kinase) | 6 | SER A 64LEU A 244ALA A 299ILE A 304ILE A 249ALA A 237 | LYS A 601 (-3.9A)NoneNoneNoneNoneNone | 1.45A | 2bxcA-2cdqA:undetectable | 2bxcA-2cdqA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n6j | ZINC METALLOPROTEASEZMP1 (Clostridioidesdifficile) |
PF07737(ATLF) | 6 | SER A 157LEU A 204LEU A 173ALA A 136ILE A 137ALA A 188 | None | 1.18A | 2bxcA-2n6jA:undetectable | 2bxcA-2n6jA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qkc | SUPEROXIDE DISMUTASE[MN] (Homo sapiens) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 6 | SER A 121GLN A 143LEU A 81HIS A 74ILE A 22ALA A 164 | None MN A 199 ( 4.9A)None MN A 199 (-3.3A)None MN A 199 ( 4.9A) | 1.15A | 2bxcA-2qkcA:undetectable | 2bxcA-2qkcA:15.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qty | POLY(ADP-RIBOSE)GLYCOHYDROLASE ARH3 (Mus musculus) |
PF03747(ADP_ribosyl_GH) | 5 | LEU A 285LEU A 289ALA A 264ILE A 309ALA A 308 | None | 0.90A | 2bxcA-2qtyA:undetectable | 2bxcA-2qtyA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rcv | SUPEROXIDE DISMUTASE[MN] (Bacillussubtilis) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 5 | SER A 129GLN A 149LEU A 89HIS A 82ALA A 169 | NoneNoneNone MN A 203 (-3.4A) MN A 203 ( 4.9A) | 1.08A | 2bxcA-2rcvA:undetectable | 2bxcA-2rcvA:14.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rfo | NUCLEOPORIN NIC96 (Saccharomycescerevisiae) |
PF04097(Nic96) | 5 | LEU A 513LEU A 260ILE A 234ILE A 508ALA A 507 | None | 1.08A | 2bxcA-2rfoA:undetectable | 2bxcA-2rfoA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vcy | TRANS-2-ENOYL-COAREDUCTASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 261LEU A 175ALA A 205ILE A 201ALA A 199 | None | 1.08A | 2bxcA-2vcyA:undetectable | 2bxcA-2vcyA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xa7 | AP-2 COMPLEX SUBUNITBETA (Homo sapiens) |
PF01602(Adaptin_N) | 5 | LEU B 436LEU B 465ILE B 451ILE B 429ALA B 430 | None | 1.04A | 2bxcA-2xa7B:undetectable | 2bxcA-2xa7B:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yjg | LACTATE RACEMASEAPOPROTEIN (Thermoanaerobacteriumthermosaccharolyticum) |
PF09861(DUF2088) | 5 | LEU A 147ALA A 231ILE A 144ILE A 155ALA A 191 | None | 0.91A | 2bxcA-2yjgA:undetectable | 2bxcA-2yjgA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yy7 | L-THREONINEDEHYDROGENASE (Flavobacteriumfrigidimaris) |
PF01370(Epimerase) | 5 | LEU A 300ALA A 253ILE A 256ILE A 191ALA A 188 | None | 1.04A | 2bxcA-2yy7A:undetectable | 2bxcA-2yy7A:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cin | MYO-INOSITOL-1-PHOSPHATESYNTHASE-RELATEDPROTEIN (Thermotogamaritima) |
PF01658(Inos-1-P_synth)PF07994(NAD_binding_5) | 5 | SER A 262ARG A 364ALA A 367ILE A 366ILE A 362 | None | 1.05A | 2bxcA-3cinA:0.6 | 2bxcA-3cinA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cps | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE (Cryptosporidiumparvum) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | SER A 324LEU A 173LEU A 246ALA A 241ILE A 239 | None | 0.76A | 2bxcA-3cpsA:undetectable | 2bxcA-3cpsA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cq5 | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Corynebacteriumglutamicum) |
PF00155(Aminotran_1_2) | 5 | LEU A 75LEU A 237ALA A 265ILE A 268ALA A 68 | None | 0.95A | 2bxcA-3cq5A:undetectable | 2bxcA-3cq5A:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dc6 | SUPEROXIDE DISMUTASE[MN] 1 (Caenorhabditiselegans) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 6 | SER A 120GLN A 142LEU A 81HIS A 74ILE A 22ALA A 163 | None MN A 198 ( 4.8A)None MN A 198 (-3.3A)None MN A 198 ( 4.9A) | 1.17A | 2bxcA-3dc6A:undetectable | 2bxcA-3dc6A:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ed5 | YFNB (Bacillussubtilis) |
PF13419(HAD_2) | 5 | LEU A 7LEU A 223ALA A 105ILE A 109ILE A 15 | None | 1.02A | 2bxcA-3ed5A:3.5 | 2bxcA-3ed5A:17.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f9i | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Rickettsiaprowazekii) |
PF13561(adh_short_C2) | 5 | LEU A 50LEU A 46ILE A 11ILE A 22ALA A 21 | None | 0.97A | 2bxcA-3f9iA:undetectable | 2bxcA-3f9iA:15.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fdq | MOTILITY GENEREPRESSOR MOGR (Listeriamonocytogenes) |
PF12181(MogR_DNAbind) | 5 | LEU A 101ALA A 82ILE A 45ILE A 86ALA A 87 | None | 1.06A | 2bxcA-3fdqA:undetectable | 2bxcA-3fdqA:14.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fxg | RHAMNONATEDEHYDRATASE (Fusariumgraminearum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLN A 343LEU A 301LEU A 307ALA A 314ILE A 294 | None | 1.01A | 2bxcA-3fxgA:undetectable | 2bxcA-3fxgA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1w | MANNOSE-6-PHOSPHATEISOMERASE (Salmonellaenterica) |
PF01238(PMI_typeI) | 5 | LEU A 352LEU A 384HIS A 326ILE A 342ALA A 341 | None | 1.07A | 2bxcA-3h1wA:undetectable | 2bxcA-3h1wA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h8f | CYTOSOLAMINOPEPTIDASE (Pseudomonasputida) |
PF00883(Peptidase_M17)PF02789(Peptidase_M17_N) | 5 | SER A 472ALA A 375ILE A 374ILE A 465ALA A 469 | None | 1.08A | 2bxcA-3h8fA:undetectable | 2bxcA-3h8fA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ite | SIDN SIDEROPHORESYNTHETASE (Epichloefestucae) |
PF00501(AMP-binding) | 5 | LEU A 144LEU A 66ALA A 89ILE A 90ILE A 86 | None | 1.07A | 2bxcA-3iteA:undetectable | 2bxcA-3iteA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3krt | CROTONYL COAREDUCTASE (Streptomycescoelicolor) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | SER A 393LEU A 398LEU A 181ILE A 58ALA A 404 | None | 1.07A | 2bxcA-3krtA:undetectable | 2bxcA-3krtA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kzu | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)SYNTHASE II (Brucellamelitensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | LEU A 386LEU A 322ILE A 308ILE A 336ALA A 333 | None | 1.04A | 2bxcA-3kzuA:undetectable | 2bxcA-3kzuA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3niw | HALOACIDDEHALOGENASE-LIKEHYDROLASE (Bacteroidesthetaiotaomicron) |
PF08282(Hydrolase_3) | 5 | LEU A 57LEU A 14ILE A 6ILE A 263ALA A 260 | None | 1.02A | 2bxcA-3niwA:undetectable | 2bxcA-3niwA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o0y | LIPOPROTEIN (Colwelliapsychrerythraea) |
PF05960(DUF885) | 5 | LEU A 207LEU A 145ALA A 179ILE A 182ALA A 257 | None | 1.03A | 2bxcA-3o0yA:undetectable | 2bxcA-3o0yA:21.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qvn | MANGANESE-CONTAININGSUPEROXIDE DISMUTASE (Candidaalbicans) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 6 | SER A 132GLN A 155LEU A 87HIS A 80ILE A 28ALA A 175 | NoneNoneNone MN A 207 (-3.4A)None MN A 207 ( 4.9A) | 1.22A | 2bxcA-3qvnA:undetectable | 2bxcA-3qvnA:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rj8 | CARBOHYDRATE OXIDASE (Microdochiumnivale) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | SER A 64LEU A 450HIS A 143ALA A 438ALA A 468 | NoneNoneFAD A 501 (-4.8A)NoneNone | 0.99A | 2bxcA-3rj8A:undetectable | 2bxcA-3rj8A:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uf6 | LMO1369 PROTEIN (Listeriamonocytogenes) |
PF01515(PTA_PTB) | 5 | LEU A 153HIS A 191ILE A 230ILE A 148ALA A 147 | None | 1.02A | 2bxcA-3uf6A:undetectable | 2bxcA-3uf6A:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wmx | NAD DEPENDENTEPIMERASE/DEHYDRATASE (Cupriavidusnecator) |
PF01370(Epimerase) | 5 | LEU A 301ALA A 254ILE A 257ILE A 192ALA A 189 | None | 1.04A | 2bxcA-3wmxA:undetectable | 2bxcA-3wmxA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ak5 | ANHYDRO-ALPHA-L-GALACTOSIDASE (Bacteroidesplebeius) |
PF04616(Glyco_hydro_43) | 5 | SER A 340LEU A 351ILE A 249ILE A 313ALA A 314 | None | 1.09A | 2bxcA-4ak5A:undetectable | 2bxcA-4ak5A:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bju | N-ACETYLGLUCOSAMINE-PHOSPHATE MUTASE (Aspergillusfumigatus) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I) | 6 | LYS A 442LEU A 417LEU A 320ARG A 322ALA A 327ILE A 332 | None | 1.32A | 2bxcA-4bjuA:undetectable | 2bxcA-4bjuA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4br6 | SUPEROXIDE DISMUTASE (Chaetomiumthermophilum) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 6 | SER A 124GLN A 146LEU A 81HIS A 74ILE A 22ALA A 165 | NoneNoneNoneMN3 A 301 (-3.5A)NoneNone | 1.17A | 2bxcA-4br6A:undetectable | 2bxcA-4br6A:15.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bvx | EUKARYOTICTRANSLATIONELONGATION FACTOR 1EPSILON-1 (Homo sapiens) |
PF00043(GST_C) | 5 | TYR B 59SER B 63LEU B 10LEU B 14ILE B 155 | None | 1.03A | 2bxcA-4bvxB:1.8 | 2bxcA-4bvxB:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c7u | SUPEROXIDE DISMUTASE[MN] 1,MITOCHONDRIAL (Arabidopsisthaliana) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 6 | SER A 124GLN A 146LEU A 81HIS A 74ILE A 22ALA A 168 | None MN A 302 ( 4.7A)None MN A 302 (-3.4A)None MN A 302 ( 4.9A) | 1.14A | 2bxcA-4c7uA:undetectable | 2bxcA-4c7uA:16.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d4z | DEOXYHYPUSINEHYDROXYLASE (Homo sapiens) |
PF13646(HEAT_2) | 5 | LEU A 107ALA A 70ILE A 71ILE A 98ALA A 97 | None | 0.84A | 2bxcA-4d4zA:undetectable | 2bxcA-4d4zA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dgk | PHYTOENEDEHYDROGENASE (Pantoeaananatis) |
PF01593(Amino_oxidase) | 5 | LEU A 230ALA A 62ILE A 63ILE A 477ALA A 15 | None | 1.07A | 2bxcA-4dgkA:1.7 | 2bxcA-4dgkA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dyk | AMIDOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 5 | LEU A 64LEU A 12ALA A 40ILE A 39ALA A 372 | None | 1.06A | 2bxcA-4dykA:undetectable | 2bxcA-4dykA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4emw | COENZYME A DISULFIDEREDUCTASE (Staphylococcusaureus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | SER A 39ALA A 306ILE A 309ILE A 20ALA A 17 | CAJ A 503 (-3.0A)NoneNoneNoneNone | 0.99A | 2bxcA-4emwA:undetectable | 2bxcA-4emwA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4h | GLUTAMINE DEPENDENTNAD+ SYNTHETASE (Burkholderiathailandensis) |
PF00795(CN_hydrolase)PF02540(NAD_synthase) | 5 | LEU A 81LEU A 39ALA A 255ILE A 256ALA A 30 | None | 1.07A | 2bxcA-4f4hA:undetectable | 2bxcA-4f4hA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f6e | SUPEROXIDE DISMUTASE[MN], MITOCHONDRIAL (Saccharomycescerevisiae) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 6 | SER A 131GLN A 154LEU A 88HIS A 81ILE A 22ALA A 173 | NoneNoneNone MN A 301 (-3.4A)None MN A 301 ( 4.9A) | 1.18A | 2bxcA-4f6eA:undetectable | 2bxcA-4f6eA:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gvr | METHENYLTETRAHYDROMETHANOPTERINCYCLOHYDROLASE (Archaeoglobusfulgidus) |
PF02289(MCH) | 5 | LEU A 115ALA A 166ILE A 137ILE A 153ALA A 154 | None | 0.93A | 2bxcA-4gvrA:undetectable | 2bxcA-4gvrA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j0k | TANNASE (Lactobacillusplantarum) |
no annotation | 5 | LEU A 400LEU A 397HIS A 207ILE A 432ALA A 431 | None | 1.04A | 2bxcA-4j0kA:undetectable | 2bxcA-4j0kA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4je3 | CENTRAL KINETOCHORESUBUNIT IML3 (Saccharomycescerevisiae) |
no annotation | 5 | GLN A 101LEU A 60LEU A 27ALA A 21ILE A 20 | None | 0.99A | 2bxcA-4je3A:undetectable | 2bxcA-4je3A:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jlw | GLUTATHIONE-INDEPENDENT FORMALDEHYDEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 165LEU A 168ILE A 359ILE A 357ALA A 351 | None | 1.01A | 2bxcA-4jlwA:undetectable | 2bxcA-4jlwA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jot | ENOYL-COA HYDRATASE,PUTATIVE (Deinococcusradiodurans) |
PF00378(ECH_1) | 5 | LEU A 158LEU A 122ALA A 176ILE A 177ALA A 182 | None | 1.00A | 2bxcA-4jotA:undetectable | 2bxcA-4jotA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgl | GLYCINEDEHYDROGENASE[DECARBOXYLATING] (Synechocystissp. PCC 6803) |
PF02347(GDC-P) | 5 | TYR A 671ALA A 64ILE A 61ILE A 807ALA A 705 | None | 0.96A | 2bxcA-4lglA:undetectable | 2bxcA-4lglA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ll6 | MYOSIN-4 (Saccharomycescerevisiae) |
PF01843(DIL) | 5 | LEU A1413ALA A1359ILE A1362ILE A1391ALA A1390 | NoneNoneACY A1502 ( 4.7A)NoneNone | 0.89A | 2bxcA-4ll6A:undetectable | 2bxcA-4ll6A:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ll8 | MYOSIN-4 (Saccharomycescerevisiae) |
PF01843(DIL) | 5 | LEU A1413ALA A1359ILE A1362ILE A1391ALA A1390 | None | 1.08A | 2bxcA-4ll8A:undetectable | 2bxcA-4ll8A:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | LEU A 70ARG A 22ALA A 98ILE A 100ILE A 95ALA A 64 | None | 1.44A | 2bxcA-4lvcA:undetectable | 2bxcA-4lvcA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | SER A 394LEU A 70ALA A 98ILE A 100ILE A 95ALA A 64 | None | 1.45A | 2bxcA-4lvcA:undetectable | 2bxcA-4lvcA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oxi | ENTEROBACTINSYNTHETASE COMPONENTF-RELATED PROTEIN (Vibrio cholerae) |
PF00501(AMP-binding) | 5 | GLN A 133LEU A 49ILE A 253ILE A 94ALA A 90 | None | 0.92A | 2bxcA-4oxiA:undetectable | 2bxcA-4oxiA:21.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4po0 | SERUM ALBUMIN (Oryctolaguscuniculus) |
PF00273(Serum_albumin) | 8 | TYR A 150SER A 192LEU A 219LEU A 238HIS A 242ARG A 257ALA A 261ILE A 290 | None | 0.67A | 2bxcA-4po0A:45.9 | 2bxcA-4po0A:74.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4po0 | SERUM ALBUMIN (Oryctolaguscuniculus) |
PF00273(Serum_albumin) | 5 | TYR A 150SER A 192LEU A 238HIS A 242ALA A 258 | None | 1.01A | 2bxcA-4po0A:45.9 | 2bxcA-4po0A:74.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qpc | 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE (Danio rerio) |
PF00551(Formyl_trans_N)PF02911(Formyl_trans_C) | 6 | LEU A 278LEU A 293ALA A 233ILE A 224ILE A 211ALA A 235 | None | 1.46A | 2bxcA-4qpcA:undetectable | 2bxcA-4qpcA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ric | FANCONI-ASSOCIATEDNUCLEASE 1 (Homo sapiens) |
PF08774(VRR_NUC) | 5 | GLN A 533LEU A 421LEU A 434ALA A 440ILE A 439 | None | 1.00A | 2bxcA-4ricA:undetectable | 2bxcA-4ricA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uzy | FLAGELLAR ASSOCIATEDPROTEIN (Chlamydomonasreinhardtii) |
PF12895(ANAPC3)PF13174(TPR_6) | 6 | SER A 423LEU A 349LEU A 317ALA A 330ILE A 357ALA A 356 | NoneFLC A1647 (-3.9A)NoneNoneNoneNone | 1.13A | 2bxcA-4uzyA:undetectable | 2bxcA-4uzyA:24.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9q | SUPEROXIDE DISMUTASE[MN] 2,MITOCHONDRIAL (Caenorhabditiselegans) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 6 | SER A 120GLN A 142LEU A 81HIS A 74ILE A 22ALA A 160 | NoneNoneNone MN A 201 (-3.4A)None MN A 201 ( 4.8A) | 1.15A | 2bxcA-4x9qA:undetectable | 2bxcA-4x9qA:15.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y1p | 3-ISOPROPYLMALATEDEHYDROGENASE (Sulfolobusacidocaldarius) |
PF00180(Iso_dh) | 5 | LEU A 315ALA A 304ILE A 305ILE A 332ALA A 331 | None | 1.09A | 2bxcA-4y1pA:undetectable | 2bxcA-4y1pA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yio | SUPEROXIDE DISMUTASE (Streptococcusthermophilus) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 5 | SER A 126GLN A 147LEU A 87HIS A 80ALA A 167 | NoneNoneNone FE A 301 (-3.3A) FE A 301 ( 4.9A) | 1.06A | 2bxcA-4yioA:undetectable | 2bxcA-4yioA:16.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a9g | MANGANESE SUPEROXIDEDISMUTASE (Sphingobacteriumspiritivorum) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 5 | SER A 123GLN A 144LEU A 83HIS A 76ALA A 168 | None MN A 301 ( 4.9A)None MN A 301 (-3.4A)None | 1.05A | 2bxcA-5a9gA:undetectable | 2bxcA-5a9gA:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aa5 | NIFE-HYDROGENASESMALL SUBUNIT, HOFK (Cupriavidusnecator) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 5 | LEU A 93LEU A 129ALA A 165ILE A 180ALA A 146 | None | 1.00A | 2bxcA-5aa5A:undetectable | 2bxcA-5aa5A:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c54 | DIHYDRODIPICOLINATESYNTHASE/N-ACETYLNEURAMINATE LYASE (Corynebacteriumglutamicum) |
PF00701(DHDPS) | 5 | SER A 264LEU A 35LEU A 31ALA A 63ILE A 67 | None | 0.95A | 2bxcA-5c54A:undetectable | 2bxcA-5c54A:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c5x | AQUAPORIN-5 (Homo sapiens) |
PF00230(MIP) | 5 | SER A 189HIS A 173ALA A 143ILE A 146ILE A 72 | None | 0.84A | 2bxcA-5c5xA:undetectable | 2bxcA-5c5xA:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5chc | DMSO REDUCTASEFAMILY TYPE IIENZYME,MOLYBDOPTERINSUBUNIT (Azospira oryzae) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 5 | SER A 575LEU A 622ALA A 154ILE A 157ILE A 133 | None | 0.88A | 2bxcA-5chcA:undetectable | 2bxcA-5chcA:19.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5dqf | SERUM ALBUMIN (Equus caballus) |
PF00273(Serum_albumin) | 5 | SER A 191LEU A 218ILE A 263ILE A 289ALA A 290 | NoneNoneNonePG4 A 602 ( 4.4A)PG4 A 602 (-3.4A) | 1.05A | 2bxcA-5dqfA:46.3 | 2bxcA-5dqfA:76.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5dqf | SERUM ALBUMIN (Equus caballus) |
PF00273(Serum_albumin) | 10 | TYR A 149LYS A 198LEU A 218LEU A 237HIS A 241ARG A 256ALA A 260ILE A 263ILE A 289ALA A 290 | PG4 A 602 (-4.9A)PG4 A 602 ( 4.3A)NonePG4 A 602 (-4.7A)PG4 A 602 (-4.0A)PG4 A 602 (-4.1A)PG4 A 602 ( 3.9A)NonePG4 A 602 ( 4.4A)PG4 A 602 (-3.4A) | 0.73A | 2bxcA-5dqfA:46.3 | 2bxcA-5dqfA:76.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5dqf | SERUM ALBUMIN (Equus caballus) |
PF00273(Serum_albumin) | 10 | TYR A 149SER A 191LEU A 218LEU A 237HIS A 241ARG A 256ALA A 260ILE A 263ILE A 289ALA A 290 | PG4 A 602 (-4.9A)NoneNonePG4 A 602 (-4.7A)PG4 A 602 (-4.0A)PG4 A 602 (-4.1A)PG4 A 602 ( 3.9A)NonePG4 A 602 ( 4.4A)PG4 A 602 (-3.4A) | 0.51A | 2bxcA-5dqfA:46.3 | 2bxcA-5dqfA:76.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fei | DISTAL TUBE PROTEIN (Bacillus virusphi29) |
PF16838(Caud_tail_N) | 5 | LEU A 174LEU A 239ILE A 252ILE A 408ALA A 407 | None | 0.98A | 2bxcA-5feiA:undetectable | 2bxcA-5feiA:21.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ghk | SERUM ALBUMIN (Canis lupus) |
PF00273(Serum_albumin) | 9 | TYR A 150SER A 192LYS A 199LEU A 219LEU A 238HIS A 242ARG A 257ALA A 261ALA A 291 | None | 0.72A | 2bxcA-5ghkA:45.1 | 2bxcA-5ghkA:79.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5huq | LACTATE RACEMIZATIONOPERON PROTEIN LARA (Lactobacillusplantarum) |
PF09861(DUF2088) | 5 | LEU A 147ALA A 231ILE A 144ILE A 155ALA A 191 | None | 0.96A | 2bxcA-5huqA:undetectable | 2bxcA-5huqA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hvo | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE(UDP-FORMING) (Aspergillusfumigatus) |
PF00982(Glyco_transf_20) | 5 | SER A 365LEU A 281ALA A 270ILE A 269ALA A 371 | None | 0.98A | 2bxcA-5hvoA:undetectable | 2bxcA-5hvoA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5id6 | CPF1 (LachnospiraceaebacteriumND2006) |
no annotation | 5 | TYR A 678LEU A 17LEU A 727ILE A 802ALA A 801 | None | 0.97A | 2bxcA-5id6A:undetectable | 2bxcA-5id6A:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8d | COAGULATION FACTORVIIICOAGULATION FACTORVIII,IG GAMMA-1CHAIN C REGION (Homo sapiens) |
PF00394(Cu-oxidase)PF00754(F5_F8_type_C)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | SER A 109LEU A 164LEU B2001HIS B1957ILE A 173 | None | 1.07A | 2bxcA-5k8dA:undetectable | 2bxcA-5k8dA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n56 | SUPEROXIDE DISMUTASE[MN/FE] 1 (Staphylococcusaureus) |
no annotation | 5 | SER A 126GLN A 146LEU A 88HIS A 81ALA A 166 | None MN A 201 ( 4.9A)None MN A 201 (-3.3A)None | 1.06A | 2bxcA-5n56A:undetectable | 2bxcA-5n56A:8.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n57 | SUPEROXIDE DISMUTASE (Staphylococcusaureus) |
no annotation | 5 | SER A 126GLN A 146LEU A 88HIS A 81ALA A 166 | NoneNoneNone MN A 201 (-3.5A) MN A 201 ( 4.9A) | 1.07A | 2bxcA-5n57A:undetectable | 2bxcA-5n57A:10.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5odr | METHYL-VIOLOGENREDUCINGHYDROGENASE, SUBUNITAMETHYL-VIOLOGENREDUCINGHYDROGENASE, SUBUNITG (Methanothermococcusthermolithotrophicus) |
PF00374(NiFeSe_Hases)PF01058(Oxidored_q6) | 6 | SER E 13LEU E 30LEU E 26ARG F 147ALA F 143ILE F 140 | None | 1.42A | 2bxcA-5odrE:undetectable | 2bxcA-5odrE:20.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ori | ALBUMIN (Capra hircus) |
no annotation | 6 | TYR A 149SER A 191GLN A 195HIS A 241ARG A 256ALA A 257 | None | 1.34A | 2bxcA-5oriA:45.6 | 2bxcA-5oriA:74.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ori | ALBUMIN (Capra hircus) |
no annotation | 11 | TYR A 149SER A 191GLN A 195LEU A 218LEU A 237HIS A 241ARG A 256ALA A 260ILE A 263ILE A 289ALA A 290 | None | 0.64A | 2bxcA-5oriA:45.6 | 2bxcA-5oriA:74.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tir | SUPEROXIDE DISMUTASE (Trichodermareesei) |
no annotation | 6 | SER A 129GLN A 149LEU A 85HIS A 78ILE A 26ALA A 168 | None MN A 301 ( 4.8A)None MN A 301 (-3.4A)NoneNone | 1.15A | 2bxcA-5tirA:undetectable | 2bxcA-5tirA:15.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v8f | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 5 (Saccharomycescerevisiae) |
PF13401(AAA_22)PF14630(ORC5_C) | 5 | SER E 412ALA E 334ILE E 337ILE E 389ALA E 392 | None | 1.07A | 2bxcA-5v8fE:undetectable | 2bxcA-5v8fE:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y81 | ACTIN-RELATEDPROTEIN 4 (Saccharomycescerevisiae) |
no annotation | 5 | LEU F 424LEU F 385ALA F 289ILE F 249ILE F 417 | None | 1.08A | 2bxcA-5y81F:undetectable | 2bxcA-5y81F:8.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yh1 | - (-) |
no annotation | 5 | LEU A 359ALA A 344ILE A 347ILE A 509ALA A 506 | None | 0.96A | 2bxcA-5yh1A:undetectable | 2bxcA-5yh1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ywz | SUNDOMAIN-CONTAININGPROTEIN 1 (Mus musculus) |
no annotation | 5 | LEU A 683ALA A 724ILE A 727ILE A 707ALA A 710 | None | 1.06A | 2bxcA-5ywzA:2.2 | 2bxcA-5ywzA:8.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yxe | SERUM ALBUMIN (Felis catus) |
no annotation | 10 | TYR A 150SER A 192LYS A 199LEU A 219LEU A 238HIS A 242ARG A 257ALA A 261ILE A 264ILE A 290 | None | 0.57A | 2bxcA-5yxeA:47.4 | 2bxcA-5yxeA:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ams | BETA SLIDING CLAMP (Pseudomonasaeruginosa) |
no annotation | 5 | GLN A 262LEU A 326ILE A 282ILE A 293ALA A 267 | None | 1.00A | 2bxcA-6amsA:undetectable | 2bxcA-6amsA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | SER A 360LEU A 70ALA A 98ILE A 100ILE A 95ALA A 64 | None | 1.41A | 2bxcA-6aphA:undetectable | 2bxcA-6aphA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbn | - (-) |
no annotation | 6 | SER A 358LEU A 68ALA A 96ILE A 98ILE A 93ALA A 62 | None | 1.44A | 2bxcA-6gbnA:undetectable | 2bxcA-6gbnA:undetectable |