SIMILAR PATTERNS OF AMINO ACIDS FOR 2BXC_A_P1ZA2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcn DELTA 2 CRYSTALLIN

(Anas
platyrhynchos)
PF00206
(Lyase_1)
PF14698
(ASL_C2)
5 LEU A 273
LEU A 275
ALA A 348
ILE A 352
ALA A 259
None
1.06A 2bxcA-1dcnA:
2.1
2bxcA-1dcnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3


(Dictyostelium
discoideum)
PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N)
5 LEU A 307
LEU A 285
ILE A 280
ILE A 348
ALA A 349
None
1.08A 2bxcA-1g8xA:
undetectable
2bxcA-1g8xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwu PII PROTEIN

(Herbaspirillum
seropedicae)
PF00543
(P-II)
5 LEU A  28
LEU A  20
ALA A  81
ILE A   8
ALA A   6
None
0.90A 2bxcA-1hwuA:
undetectable
2bxcA-1hwuA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE


(Sulfolobus
acidocaldarius)
PF00128
(Alpha-amylase)
PF09196
(DUF1953)
6 LEU A 343
LEU A 380
ALA A 369
ILE A 366
ILE A 334
ALA A 329
None
None
None
None
None
MLZ  A 326 ( 3.6A)
1.14A 2bxcA-1iv8A:
0.0
2bxcA-1iv8A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A


(Dictyostelium
discoideum)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
5 LEU A 318
LEU A 296
ILE A 291
ILE A 359
ALA A 360
None
1.08A 2bxcA-1jx2A:
undetectable
2bxcA-1jx2A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkc MANGANESE SUPEROXIDE
DISMUTASE


(Aspergillus
fumigatus)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
6 SER A 139
GLN A 161
LEU A  95
HIS A  88
ILE A  36
ALA A 179
None
MN  A2001 ( 4.8A)
None
MN  A2001 (-3.4A)
None
MN  A2001 ( 4.8A)
1.13A 2bxcA-1kkcA:
undetectable
2bxcA-1kkcA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0n ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Bacillus
subtilis)
PF01070
(FMN_dh)
5 SER A 257
ALA A 141
ILE A 139
ILE A 119
ALA A  90
None
1.06A 2bxcA-1p0nA:
undetectable
2bxcA-1p0nA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE


(Trypanosoma
brucei)
PF00393
(6PGD)
PF03446
(NAD_binding_2)
5 LEU A 374
ALA A 336
ILE A 337
ILE A 198
ALA A 194
None
1.05A 2bxcA-1pgjA:
undetectable
2bxcA-1pgjA:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
5 TYR A 150
SER A 192
GLN A 196
HIS A 242
ALA A 258
DKA  A1003 (-4.4A)
None
None
DKA  A1003 (-3.7A)
None
0.91A 2bxcA-1tf0A:
47.4
2bxcA-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
12 TYR A 150
SER A 192
GLN A 196
LYS A 199
LEU A 219
LEU A 238
HIS A 242
ARG A 257
ALA A 261
ILE A 264
ILE A 290
ALA A 291
DKA  A1003 (-4.4A)
None
None
CIT  A2001 ( 2.7A)
None
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
DKA  A1003 (-4.1A)
None
None
DKA  A1003 ( 4.5A)
CIT  A2001 ( 3.9A)
0.45A 2bxcA-1tf0A:
47.4
2bxcA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqw PUTATIVE BINDING
PROTEIN YLIB


(Escherichia
coli)
PF00496
(SBP_bac_5)
5 LEU A  42
ALA A 388
ILE A 243
ILE A 295
ALA A 296
None
None
None
None
GOL  A 551 (-3.4A)
0.94A 2bxcA-1uqwA:
undetectable
2bxcA-1uqwA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN


(Escherichia
coli)
PF04257
(Exonuc_V_gamma)
5 LEU C 224
LEU C 314
ILE C 213
ILE C 216
ALA C 218
None
1.05A 2bxcA-1w36C:
undetectable
2bxcA-1w36C:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bco SUCCINYLGLUTAMATE
DESUCCINYLASE


(Vibrio
parahaemolyticus)
PF04952
(AstE_AspA)
5 SER A 254
LEU A 152
ALA A 246
ILE A 245
ALA A 240
None
1.08A 2bxcA-2bcoA:
undetectable
2bxcA-2bcoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana)
PF00696
(AA_kinase)
6 SER A  64
LEU A 244
ALA A 299
ILE A 304
ILE A 249
ALA A 237
LYS  A 601 (-3.9A)
None
None
None
None
None
1.45A 2bxcA-2cdqA:
undetectable
2bxcA-2cdqA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n6j ZINC METALLOPROTEASE
ZMP1


(Clostridioides
difficile)
PF07737
(ATLF)
6 SER A 157
LEU A 204
LEU A 173
ALA A 136
ILE A 137
ALA A 188
None
1.18A 2bxcA-2n6jA:
undetectable
2bxcA-2n6jA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkc SUPEROXIDE DISMUTASE
[MN]


(Homo sapiens)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
6 SER A 121
GLN A 143
LEU A  81
HIS A  74
ILE A  22
ALA A 164
None
MN  A 199 ( 4.9A)
None
MN  A 199 (-3.3A)
None
MN  A 199 ( 4.9A)
1.15A 2bxcA-2qkcA:
undetectable
2bxcA-2qkcA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3


(Mus musculus)
PF03747
(ADP_ribosyl_GH)
5 LEU A 285
LEU A 289
ALA A 264
ILE A 309
ALA A 308
None
0.90A 2bxcA-2qtyA:
undetectable
2bxcA-2qtyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcv SUPEROXIDE DISMUTASE
[MN]


(Bacillus
subtilis)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
5 SER A 129
GLN A 149
LEU A  89
HIS A  82
ALA A 169
None
None
None
MN  A 203 (-3.4A)
MN  A 203 ( 4.9A)
1.08A 2bxcA-2rcvA:
undetectable
2bxcA-2rcvA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae)
PF04097
(Nic96)
5 LEU A 513
LEU A 260
ILE A 234
ILE A 508
ALA A 507
None
1.08A 2bxcA-2rfoA:
undetectable
2bxcA-2rfoA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcy TRANS-2-ENOYL-COA
REDUCTASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 LEU A 261
LEU A 175
ALA A 205
ILE A 201
ALA A 199
None
1.08A 2bxcA-2vcyA:
undetectable
2bxcA-2vcyA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 AP-2 COMPLEX SUBUNIT
BETA


(Homo sapiens)
PF01602
(Adaptin_N)
5 LEU B 436
LEU B 465
ILE B 451
ILE B 429
ALA B 430
None
1.04A 2bxcA-2xa7B:
undetectable
2bxcA-2xa7B:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjg LACTATE RACEMASE
APOPROTEIN


(Thermoanaerobacterium
thermosaccharolyticum)
PF09861
(DUF2088)
5 LEU A 147
ALA A 231
ILE A 144
ILE A 155
ALA A 191
None
0.91A 2bxcA-2yjgA:
undetectable
2bxcA-2yjgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy7 L-THREONINE
DEHYDROGENASE


(Flavobacterium
frigidimaris)
PF01370
(Epimerase)
5 LEU A 300
ALA A 253
ILE A 256
ILE A 191
ALA A 188
None
1.04A 2bxcA-2yy7A:
undetectable
2bxcA-2yy7A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN


(Thermotoga
maritima)
PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5)
5 SER A 262
ARG A 364
ALA A 367
ILE A 366
ILE A 362
None
1.05A 2bxcA-3cinA:
0.6
2bxcA-3cinA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE


(Cryptosporidium
parvum)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 SER A 324
LEU A 173
LEU A 246
ALA A 241
ILE A 239
None
0.76A 2bxcA-3cpsA:
undetectable
2bxcA-3cpsA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Corynebacterium
glutamicum)
PF00155
(Aminotran_1_2)
5 LEU A  75
LEU A 237
ALA A 265
ILE A 268
ALA A  68
None
0.95A 2bxcA-3cq5A:
undetectable
2bxcA-3cq5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc6 SUPEROXIDE DISMUTASE
[MN] 1


(Caenorhabditis
elegans)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
6 SER A 120
GLN A 142
LEU A  81
HIS A  74
ILE A  22
ALA A 163
None
MN  A 198 ( 4.8A)
None
MN  A 198 (-3.3A)
None
MN  A 198 ( 4.9A)
1.17A 2bxcA-3dc6A:
undetectable
2bxcA-3dc6A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed5 YFNB

(Bacillus
subtilis)
PF13419
(HAD_2)
5 LEU A   7
LEU A 223
ALA A 105
ILE A 109
ILE A  15
None
1.02A 2bxcA-3ed5A:
3.5
2bxcA-3ed5A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9i 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Rickettsia
prowazekii)
PF13561
(adh_short_C2)
5 LEU A  50
LEU A  46
ILE A  11
ILE A  22
ALA A  21
None
0.97A 2bxcA-3f9iA:
undetectable
2bxcA-3f9iA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdq MOTILITY GENE
REPRESSOR MOGR


(Listeria
monocytogenes)
PF12181
(MogR_DNAbind)
5 LEU A 101
ALA A  82
ILE A  45
ILE A  86
ALA A  87
None
1.06A 2bxcA-3fdqA:
undetectable
2bxcA-3fdqA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxg RHAMNONATE
DEHYDRATASE


(Fusarium
graminearum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLN A 343
LEU A 301
LEU A 307
ALA A 314
ILE A 294
None
1.01A 2bxcA-3fxgA:
undetectable
2bxcA-3fxgA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1w MANNOSE-6-PHOSPHATE
ISOMERASE


(Salmonella
enterica)
PF01238
(PMI_typeI)
5 LEU A 352
LEU A 384
HIS A 326
ILE A 342
ALA A 341
None
1.07A 2bxcA-3h1wA:
undetectable
2bxcA-3h1wA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE


(Pseudomonas
putida)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
5 SER A 472
ALA A 375
ILE A 374
ILE A 465
ALA A 469
None
1.08A 2bxcA-3h8fA:
undetectable
2bxcA-3h8fA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ite SIDN SIDEROPHORE
SYNTHETASE


(Epichloe
festucae)
PF00501
(AMP-binding)
5 LEU A 144
LEU A  66
ALA A  89
ILE A  90
ILE A  86
None
1.07A 2bxcA-3iteA:
undetectable
2bxcA-3iteA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE


(Streptomyces
coelicolor)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 SER A 393
LEU A 398
LEU A 181
ILE A  58
ALA A 404
None
1.07A 2bxcA-3krtA:
undetectable
2bxcA-3krtA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II


(Brucella
melitensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 LEU A 386
LEU A 322
ILE A 308
ILE A 336
ALA A 333
None
1.04A 2bxcA-3kzuA:
undetectable
2bxcA-3kzuA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niw HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Bacteroides
thetaiotaomicron)
PF08282
(Hydrolase_3)
5 LEU A  57
LEU A  14
ILE A   6
ILE A 263
ALA A 260
None
1.02A 2bxcA-3niwA:
undetectable
2bxcA-3niwA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0y LIPOPROTEIN

(Colwellia
psychrerythraea)
PF05960
(DUF885)
5 LEU A 207
LEU A 145
ALA A 179
ILE A 182
ALA A 257
None
1.03A 2bxcA-3o0yA:
undetectable
2bxcA-3o0yA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvn MANGANESE-CONTAINING
SUPEROXIDE DISMUTASE


(Candida
albicans)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
6 SER A 132
GLN A 155
LEU A  87
HIS A  80
ILE A  28
ALA A 175
None
None
None
MN  A 207 (-3.4A)
None
MN  A 207 ( 4.9A)
1.22A 2bxcA-3qvnA:
undetectable
2bxcA-3qvnA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj8 CARBOHYDRATE OXIDASE

(Microdochium
nivale)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 SER A  64
LEU A 450
HIS A 143
ALA A 438
ALA A 468
None
None
FAD  A 501 (-4.8A)
None
None
0.99A 2bxcA-3rj8A:
undetectable
2bxcA-3rj8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf6 LMO1369 PROTEIN

(Listeria
monocytogenes)
PF01515
(PTA_PTB)
5 LEU A 153
HIS A 191
ILE A 230
ILE A 148
ALA A 147
None
1.02A 2bxcA-3uf6A:
undetectable
2bxcA-3uf6A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E


(Cupriavidus
necator)
PF01370
(Epimerase)
5 LEU A 301
ALA A 254
ILE A 257
ILE A 192
ALA A 189
None
1.04A 2bxcA-3wmxA:
undetectable
2bxcA-3wmxA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE


(Bacteroides
plebeius)
PF04616
(Glyco_hydro_43)
5 SER A 340
LEU A 351
ILE A 249
ILE A 313
ALA A 314
None
1.09A 2bxcA-4ak5A:
undetectable
2bxcA-4ak5A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE


(Aspergillus
fumigatus)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
6 LYS A 442
LEU A 417
LEU A 320
ARG A 322
ALA A 327
ILE A 332
None
1.32A 2bxcA-4bjuA:
undetectable
2bxcA-4bjuA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4br6 SUPEROXIDE DISMUTASE

(Chaetomium
thermophilum)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
6 SER A 124
GLN A 146
LEU A  81
HIS A  74
ILE A  22
ALA A 165
None
None
None
MN3  A 301 (-3.5A)
None
None
1.17A 2bxcA-4br6A:
undetectable
2bxcA-4br6A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1


(Homo sapiens)
PF00043
(GST_C)
5 TYR B  59
SER B  63
LEU B  10
LEU B  14
ILE B 155
None
1.03A 2bxcA-4bvxB:
1.8
2bxcA-4bvxB:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7u SUPEROXIDE DISMUTASE
[MN] 1,
MITOCHONDRIAL


(Arabidopsis
thaliana)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
6 SER A 124
GLN A 146
LEU A  81
HIS A  74
ILE A  22
ALA A 168
None
MN  A 302 ( 4.7A)
None
MN  A 302 (-3.4A)
None
MN  A 302 ( 4.9A)
1.14A 2bxcA-4c7uA:
undetectable
2bxcA-4c7uA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4z DEOXYHYPUSINE
HYDROXYLASE


(Homo sapiens)
PF13646
(HEAT_2)
5 LEU A 107
ALA A  70
ILE A  71
ILE A  98
ALA A  97
None
0.84A 2bxcA-4d4zA:
undetectable
2bxcA-4d4zA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgk PHYTOENE
DEHYDROGENASE


(Pantoea
ananatis)
PF01593
(Amino_oxidase)
5 LEU A 230
ALA A  62
ILE A  63
ILE A 477
ALA A  15
None
1.07A 2bxcA-4dgkA:
1.7
2bxcA-4dgkA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa)
PF01979
(Amidohydro_1)
5 LEU A  64
LEU A  12
ALA A  40
ILE A  39
ALA A 372
None
1.06A 2bxcA-4dykA:
undetectable
2bxcA-4dykA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emw COENZYME A DISULFIDE
REDUCTASE


(Staphylococcus
aureus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 SER A  39
ALA A 306
ILE A 309
ILE A  20
ALA A  17
CAJ  A 503 (-3.0A)
None
None
None
None
0.99A 2bxcA-4emwA:
undetectable
2bxcA-4emwA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE


(Burkholderia
thailandensis)
PF00795
(CN_hydrolase)
PF02540
(NAD_synthase)
5 LEU A  81
LEU A  39
ALA A 255
ILE A 256
ALA A  30
None
1.07A 2bxcA-4f4hA:
undetectable
2bxcA-4f4hA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
6 SER A 131
GLN A 154
LEU A  88
HIS A  81
ILE A  22
ALA A 173
None
None
None
MN  A 301 (-3.4A)
None
MN  A 301 ( 4.9A)
1.18A 2bxcA-4f6eA:
undetectable
2bxcA-4f6eA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE


(Archaeoglobus
fulgidus)
PF02289
(MCH)
5 LEU A 115
ALA A 166
ILE A 137
ILE A 153
ALA A 154
None
0.93A 2bxcA-4gvrA:
undetectable
2bxcA-4gvrA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum)
no annotation 5 LEU A 400
LEU A 397
HIS A 207
ILE A 432
ALA A 431
None
1.04A 2bxcA-4j0kA:
undetectable
2bxcA-4j0kA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je3 CENTRAL KINETOCHORE
SUBUNIT IML3


(Saccharomyces
cerevisiae)
no annotation 5 GLN A 101
LEU A  60
LEU A  27
ALA A  21
ILE A  20
None
0.99A 2bxcA-4je3A:
undetectable
2bxcA-4je3A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 LEU A 165
LEU A 168
ILE A 359
ILE A 357
ALA A 351
None
1.01A 2bxcA-4jlwA:
undetectable
2bxcA-4jlwA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jot ENOYL-COA HYDRATASE,
PUTATIVE


(Deinococcus
radiodurans)
PF00378
(ECH_1)
5 LEU A 158
LEU A 122
ALA A 176
ILE A 177
ALA A 182
None
1.00A 2bxcA-4jotA:
undetectable
2bxcA-4jotA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]


(Synechocystis
sp. PCC 6803)
PF02347
(GDC-P)
5 TYR A 671
ALA A  64
ILE A  61
ILE A 807
ALA A 705
None
0.96A 2bxcA-4lglA:
undetectable
2bxcA-4lglA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll6 MYOSIN-4

(Saccharomyces
cerevisiae)
PF01843
(DIL)
5 LEU A1413
ALA A1359
ILE A1362
ILE A1391
ALA A1390
None
None
ACY  A1502 ( 4.7A)
None
None
0.89A 2bxcA-4ll6A:
undetectable
2bxcA-4ll6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4

(Saccharomyces
cerevisiae)
PF01843
(DIL)
5 LEU A1413
ALA A1359
ILE A1362
ILE A1391
ALA A1390
None
1.08A 2bxcA-4ll8A:
undetectable
2bxcA-4ll8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)


(Bradyrhizobium
elkanii)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
6 LEU A  70
ARG A  22
ALA A  98
ILE A 100
ILE A  95
ALA A  64
None
1.44A 2bxcA-4lvcA:
undetectable
2bxcA-4lvcA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)


(Bradyrhizobium
elkanii)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
6 SER A 394
LEU A  70
ALA A  98
ILE A 100
ILE A  95
ALA A  64
None
1.45A 2bxcA-4lvcA:
undetectable
2bxcA-4lvcA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN


(Vibrio cholerae)
PF00501
(AMP-binding)
5 GLN A 133
LEU A  49
ILE A 253
ILE A  94
ALA A  90
None
0.92A 2bxcA-4oxiA:
undetectable
2bxcA-4oxiA:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
8 TYR A 150
SER A 192
LEU A 219
LEU A 238
HIS A 242
ARG A 257
ALA A 261
ILE A 290
None
0.67A 2bxcA-4po0A:
45.9
2bxcA-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
5 TYR A 150
SER A 192
LEU A 238
HIS A 242
ALA A 258
None
1.01A 2bxcA-4po0A:
45.9
2bxcA-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpc 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE


(Danio rerio)
PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C)
6 LEU A 278
LEU A 293
ALA A 233
ILE A 224
ILE A 211
ALA A 235
None
1.46A 2bxcA-4qpcA:
undetectable
2bxcA-4qpcA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ric FANCONI-ASSOCIATED
NUCLEASE 1


(Homo sapiens)
PF08774
(VRR_NUC)
5 GLN A 533
LEU A 421
LEU A 434
ALA A 440
ILE A 439
None
1.00A 2bxcA-4ricA:
undetectable
2bxcA-4ricA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzy FLAGELLAR ASSOCIATED
PROTEIN


(Chlamydomonas
reinhardtii)
PF12895
(ANAPC3)
PF13174
(TPR_6)
6 SER A 423
LEU A 349
LEU A 317
ALA A 330
ILE A 357
ALA A 356
None
FLC  A1647 (-3.9A)
None
None
None
None
1.13A 2bxcA-4uzyA:
undetectable
2bxcA-4uzyA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9q SUPEROXIDE DISMUTASE
[MN] 2,
MITOCHONDRIAL


(Caenorhabditis
elegans)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
6 SER A 120
GLN A 142
LEU A  81
HIS A  74
ILE A  22
ALA A 160
None
None
None
MN  A 201 (-3.4A)
None
MN  A 201 ( 4.8A)
1.15A 2bxcA-4x9qA:
undetectable
2bxcA-4x9qA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE


(Sulfolobus
acidocaldarius)
PF00180
(Iso_dh)
5 LEU A 315
ALA A 304
ILE A 305
ILE A 332
ALA A 331
None
1.09A 2bxcA-4y1pA:
undetectable
2bxcA-4y1pA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yio SUPEROXIDE DISMUTASE

(Streptococcus
thermophilus)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
5 SER A 126
GLN A 147
LEU A  87
HIS A  80
ALA A 167
None
None
None
FE  A 301 (-3.3A)
FE  A 301 ( 4.9A)
1.06A 2bxcA-4yioA:
undetectable
2bxcA-4yioA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9g MANGANESE SUPEROXIDE
DISMUTASE


(Sphingobacterium
spiritivorum)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
5 SER A 123
GLN A 144
LEU A  83
HIS A  76
ALA A 168
None
MN  A 301 ( 4.9A)
None
MN  A 301 (-3.4A)
None
1.05A 2bxcA-5a9gA:
undetectable
2bxcA-5a9gA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK


(Cupriavidus
necator)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
5 LEU A  93
LEU A 129
ALA A 165
ILE A 180
ALA A 146
None
1.00A 2bxcA-5aa5A:
undetectable
2bxcA-5aa5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c54 DIHYDRODIPICOLINATE
SYNTHASE/N-ACETYLNEU
RAMINATE LYASE


(Corynebacterium
glutamicum)
PF00701
(DHDPS)
5 SER A 264
LEU A  35
LEU A  31
ALA A  63
ILE A  67
None
0.95A 2bxcA-5c54A:
undetectable
2bxcA-5c54A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5x AQUAPORIN-5

(Homo sapiens)
PF00230
(MIP)
5 SER A 189
HIS A 173
ALA A 143
ILE A 146
ILE A  72
None
0.84A 2bxcA-5c5xA:
undetectable
2bxcA-5c5xA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT


(Azospira oryzae)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 SER A 575
LEU A 622
ALA A 154
ILE A 157
ILE A 133
None
0.88A 2bxcA-5chcA:
undetectable
2bxcA-5chcA:
19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
5 SER A 191
LEU A 218
ILE A 263
ILE A 289
ALA A 290
None
None
None
PG4  A 602 ( 4.4A)
PG4  A 602 (-3.4A)
1.05A 2bxcA-5dqfA:
46.3
2bxcA-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
10 TYR A 149
LYS A 198
LEU A 218
LEU A 237
HIS A 241
ARG A 256
ALA A 260
ILE A 263
ILE A 289
ALA A 290
PG4  A 602 (-4.9A)
PG4  A 602 ( 4.3A)
None
PG4  A 602 (-4.7A)
PG4  A 602 (-4.0A)
PG4  A 602 (-4.1A)
PG4  A 602 ( 3.9A)
None
PG4  A 602 ( 4.4A)
PG4  A 602 (-3.4A)
0.73A 2bxcA-5dqfA:
46.3
2bxcA-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
10 TYR A 149
SER A 191
LEU A 218
LEU A 237
HIS A 241
ARG A 256
ALA A 260
ILE A 263
ILE A 289
ALA A 290
PG4  A 602 (-4.9A)
None
None
PG4  A 602 (-4.7A)
PG4  A 602 (-4.0A)
PG4  A 602 (-4.1A)
PG4  A 602 ( 3.9A)
None
PG4  A 602 ( 4.4A)
PG4  A 602 (-3.4A)
0.51A 2bxcA-5dqfA:
46.3
2bxcA-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fei DISTAL TUBE PROTEIN

(Bacillus virus
phi29)
PF16838
(Caud_tail_N)
5 LEU A 174
LEU A 239
ILE A 252
ILE A 408
ALA A 407
None
0.98A 2bxcA-5feiA:
undetectable
2bxcA-5feiA:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
9 TYR A 150
SER A 192
LYS A 199
LEU A 219
LEU A 238
HIS A 242
ARG A 257
ALA A 261
ALA A 291
None
0.72A 2bxcA-5ghkA:
45.1
2bxcA-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA


(Lactobacillus
plantarum)
PF09861
(DUF2088)
5 LEU A 147
ALA A 231
ILE A 144
ILE A 155
ALA A 191
None
0.96A 2bxcA-5huqA:
undetectable
2bxcA-5huqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)


(Aspergillus
fumigatus)
PF00982
(Glyco_transf_20)
5 SER A 365
LEU A 281
ALA A 270
ILE A 269
ALA A 371
None
0.98A 2bxcA-5hvoA:
undetectable
2bxcA-5hvoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id6 CPF1

(Lachnospiraceae
bacterium
ND2006)
no annotation 5 TYR A 678
LEU A  17
LEU A 727
ILE A 802
ALA A 801
None
0.97A 2bxcA-5id6A:
undetectable
2bxcA-5id6A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION


(Homo sapiens)
PF00394
(Cu-oxidase)
PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
5 SER A 109
LEU A 164
LEU B2001
HIS B1957
ILE A 173
None
1.07A 2bxcA-5k8dA:
undetectable
2bxcA-5k8dA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n56 SUPEROXIDE DISMUTASE
[MN/FE] 1


(Staphylococcus
aureus)
no annotation 5 SER A 126
GLN A 146
LEU A  88
HIS A  81
ALA A 166
None
MN  A 201 ( 4.9A)
None
MN  A 201 (-3.3A)
None
1.06A 2bxcA-5n56A:
undetectable
2bxcA-5n56A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n57 SUPEROXIDE DISMUTASE

(Staphylococcus
aureus)
no annotation 5 SER A 126
GLN A 146
LEU A  88
HIS A  81
ALA A 166
None
None
None
MN  A 201 (-3.5A)
MN  A 201 ( 4.9A)
1.07A 2bxcA-5n57A:
undetectable
2bxcA-5n57A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G


(Methanothermococcus
thermolithotrophicus)
PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
6 SER E  13
LEU E  30
LEU E  26
ARG F 147
ALA F 143
ILE F 140
None
1.42A 2bxcA-5odrE:
undetectable
2bxcA-5odrE:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 6 TYR A 149
SER A 191
GLN A 195
HIS A 241
ARG A 256
ALA A 257
None
1.34A 2bxcA-5oriA:
45.6
2bxcA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 11 TYR A 149
SER A 191
GLN A 195
LEU A 218
LEU A 237
HIS A 241
ARG A 256
ALA A 260
ILE A 263
ILE A 289
ALA A 290
None
0.64A 2bxcA-5oriA:
45.6
2bxcA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tir SUPEROXIDE DISMUTASE

(Trichoderma
reesei)
no annotation 6 SER A 129
GLN A 149
LEU A  85
HIS A  78
ILE A  26
ALA A 168
None
MN  A 301 ( 4.8A)
None
MN  A 301 (-3.4A)
None
None
1.15A 2bxcA-5tirA:
undetectable
2bxcA-5tirA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5


(Saccharomyces
cerevisiae)
PF13401
(AAA_22)
PF14630
(ORC5_C)
5 SER E 412
ALA E 334
ILE E 337
ILE E 389
ALA E 392
None
1.07A 2bxcA-5v8fE:
undetectable
2bxcA-5v8fE:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y81 ACTIN-RELATED
PROTEIN 4


(Saccharomyces
cerevisiae)
no annotation 5 LEU F 424
LEU F 385
ALA F 289
ILE F 249
ILE F 417
None
1.08A 2bxcA-5y81F:
undetectable
2bxcA-5y81F:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh1 -

(-)
no annotation 5 LEU A 359
ALA A 344
ILE A 347
ILE A 509
ALA A 506
None
0.96A 2bxcA-5yh1A:
undetectable
2bxcA-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywz SUN
DOMAIN-CONTAINING
PROTEIN 1


(Mus musculus)
no annotation 5 LEU A 683
ALA A 724
ILE A 727
ILE A 707
ALA A 710
None
1.06A 2bxcA-5ywzA:
2.2
2bxcA-5ywzA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 10 TYR A 150
SER A 192
LYS A 199
LEU A 219
LEU A 238
HIS A 242
ARG A 257
ALA A 261
ILE A 264
ILE A 290
None
0.57A 2bxcA-5yxeA:
47.4
2bxcA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa)
no annotation 5 GLN A 262
LEU A 326
ILE A 282
ILE A 293
ALA A 267
None
1.00A 2bxcA-6amsA:
undetectable
2bxcA-6amsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aph ADENOSYLHOMOCYSTEINA
SE


(Elizabethkingia
anophelis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
6 SER A 360
LEU A  70
ALA A  98
ILE A 100
ILE A  95
ALA A  64
None
1.41A 2bxcA-6aphA:
undetectable
2bxcA-6aphA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-)
no annotation 6 SER A 358
LEU A  68
ALA A  96
ILE A  98
ILE A  93
ALA A  62
None
1.44A 2bxcA-6gbnA:
undetectable
2bxcA-6gbnA:
undetectable