SIMILAR PATTERNS OF AMINO ACIDS FOR 2BU8_A_TF4A1379_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 LEU A 101
TYR A 106
ILE A 123
ILE A 121
 None
 0.83A 2bu8A-1b25A:
0.0		 2bu8A-1b25A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 LEU A 255
ILE A 232
ILE A 144
ARG A 141
 None
 0.85A 2bu8A-1c0aA:
1.3		 2bu8A-1c0aA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 LEU C 464
TYR C 468
ILE A  68
ILE C 397
 None
 0.75A 2bu8A-1d7wC:
undetectable		 2bu8A-1d7wC:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dc1 BSOBI RESTRICTION
ENDONUCLEASE

(Geobacillus
stearothermophilus) 		PF09194
(Endonuc-BsobI) 		4 LEU A 142
ILE A 320
ILE A 280
ILE A 278
 None
 0.64A 2bu8A-1dc1A:
undetectable		 2bu8A-1dc1A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1

(Enterovirus B) 		PF00073
(Rhv) 		4 LEU 1 219
TYR 1 146
ILE 1 119
ILE 1  95
 None
PLM  1   0 (-3.7A)
None
PLM  1   0 ( 4.6A)
 0.75A 2bu8A-1ev11:
undetectable		 2bu8A-1ev11:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3o HYPOTHETICAL ABC
TRANSPORTER
ATP-BINDING PROTEIN
MJ0796

(Methanocaldococcus
jannaschii) 		PF00005
(ABC_tran) 		4 LEU A 168
ILE A   2
ILE A  85
ILE A  64
 None
 0.77A 2bu8A-1f3oA:
undetectable		 2bu8A-1f3oA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		4 LEU A 147
ILE A 306
ILE A 157
ILE A 161
 None
 0.77A 2bu8A-1floA:
0.0		 2bu8A-1floA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvf SEC1

(Doryteuthis
pealeii) 		PF00995
(Sec1) 		4 TYR A 400
ILE A 430
ARG A 586
ILE A 437
 None
 0.82A 2bu8A-1fvfA:
0.1		 2bu8A-1fvfA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gec GLYCYL ENDOPEPTIDASE

(Carica papaya) 		PF00112
(Peptidase_C1) 		4 LEU E 121
TYR E 207
ILE E 175
ILE E 177
 None
 0.69A 2bu8A-1gecE:
undetectable		 2bu8A-1gecE:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE

(Rattus
norvegicus) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 LEU A 247
ILE A 201
ILE A 283
ILE A 281
 None
 0.77A 2bu8A-1gjvA:
17.1		 2bu8A-1gjvA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE

(Rattus
norvegicus) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 TYR A  99
HIS A 132
ARG A 167
ILE A 170
 None
 0.74A 2bu8A-1gjvA:
17.1		 2bu8A-1gjvA:
31.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 LEU B  89
ILE B 160
ILE B 119
ARG B 120
ILE B 134
 None
 1.12A 2bu8A-1gl9B:
undetectable		 2bu8A-1gl9B:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyb RIBONUCLEASE

(Nicotiana
glutinosa) 		PF00445
(Ribonuclease_T2) 		4 LEU A 170
ILE A 173
ILE A 144
ILE A 148
 None
 0.80A 2bu8A-1iybA:
undetectable		 2bu8A-1iybA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krq FERRITIN

(Campylobacter
jejuni) 		PF00210
(Ferritin) 		4 LEU A  83
ILE A 158
ILE A 141
ILE A 137
 None
 0.69A 2bu8A-1krqA:
3.7		 2bu8A-1krqA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyt SHIKIMATE
5-DEHYDROGENASE

(Escherichia
coli) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 LEU A 106
ILE A 116
ILE A 185
ILE A 122
 None
 0.79A 2bu8A-1nytA:
undetectable		 2bu8A-1nytA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pci PROCARICAIN

(Carica papaya) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 LEU A 121
TYR A 207
ILE A 175
ILE A 177
 None
 0.68A 2bu8A-1pciA:
undetectable		 2bu8A-1pciA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ppo PROTEASE OMEGA

(Carica papaya) 		PF00112
(Peptidase_C1) 		4 LEU A 121
TYR A 207
ILE A 175
ILE A 177
 None
 0.70A 2bu8A-1ppoA:
undetectable		 2bu8A-1ppoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A 551
ILE A 225
ARG A 208
ILE A 290
 None
 0.83A 2bu8A-1q8yA:
undetectable		 2bu8A-1q8yA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1reg T4 REGA

(Escherichia
virus T4) 		PF01818
(Translat_reg) 		4 LEU X   6
ILE X  38
ILE X  84
ILE X  47
 None
 0.79A 2bu8A-1regX:
undetectable		 2bu8A-1regX:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		4 LEU A 224
ILE A 159
ILE A 203
ARG A 231
 None
 0.79A 2bu8A-1rt8A:
undetectable		 2bu8A-1rt8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s04 HYPOTHETICAL PROTEIN
PF0455

(Pyrococcus
furiosus) 		PF04266
(ASCH) 		4 ILE A  40
ARG A  25
ILE A 103
ILE A 105
 None
 0.85A 2bu8A-1s04A:
undetectable		 2bu8A-1s04A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		4 LEU B1932
ILE B1935
ILE B2000
ILE B2002
 None
 0.81A 2bu8A-1sddB:
undetectable		 2bu8A-1sddB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdo BSTYI

(Geobacillus
stearothermophilus) 		PF09195
(Endonuc-BglII) 		4 LEU A  68
ILE A 160
ILE A  30
ILE A  31
 None
 0.80A 2bu8A-1sdoA:
undetectable		 2bu8A-1sdoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sma MALTOGENIC AMYLASE

(Thermus sp.
IM6501) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 LEU A 188
ILE A 455
ILE A 494
ARG A 497
 None
 0.85A 2bu8A-1smaA:
undetectable		 2bu8A-1smaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcs TRICHOSANTHIN

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		4 LEU A 154
ILE A  50
ILE A  71
ILE A  64
 None
None
NDP  A 280 (-4.5A)
None
 0.79A 2bu8A-1tcsA:
undetectable		 2bu8A-1tcsA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 LEU A 351
TYR A 349
ILE A 303
ILE A 299
 None
 0.70A 2bu8A-1tp7A:
undetectable		 2bu8A-1tp7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		4 LEU C 892
ILE C 932
ILE C 916
ILE C 917
 None
 0.74A 2bu8A-1u6gC:
2.0		 2bu8A-1u6gC:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc3 GLOBIN

(Lampetra
fluviatilis) 		PF00042
(Globin) 		4 LEU A 119
ILE A  37
ILE A  77
ILE A  78
 HEM  A 150 (-4.3A)
None
HEM  A 150 ( 4.2A)
None
 0.76A 2bu8A-1uc3A:
undetectable		 2bu8A-1uc3A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47) 		PF00544
(Pec_lyase_C) 		4 LEU A  41
ILE A 145
ILE A 136
ILE A 163
 None
 0.84A 2bu8A-1vblA:
undetectable		 2bu8A-1vblA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhc PUTATIVE KHG/KDPG
ALDOLASE

(Haemophilus
influenzae) 		PF01081
(Aldolase) 		4 LEU A  36
ILE A  21
ILE A 200
ILE A 192
 None
 0.82A 2bu8A-1vhcA:
undetectable		 2bu8A-1vhcA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpv UPF0230 PROTEIN
TM1468

(Thermotoga
maritima) 		PF02645
(DegV) 		5 LEU A 250
TYR A 254
ILE A 281
ILE A 217
ILE A 161
 None
 1.08A 2bu8A-1vpvA:
undetectable		 2bu8A-1vpvA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x94 PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE

(Vibrio cholerae) 		PF13580
(SIS_2) 		5 LEU A  66
TYR A  70
ILE A  37
ILE A 183
ILE A 182
 None
 0.87A 2bu8A-1x94A:
undetectable		 2bu8A-1x94A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 LEU A 351
TYR A 349
ILE A 303
ILE A 299
 None
 0.73A 2bu8A-1xr6A:
undetectable		 2bu8A-1xr6A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		4 LEU A  87
ILE A 219
ARG A  52
ILE A 223
 None
 0.84A 2bu8A-1xt8A:
undetectable		 2bu8A-1xt8A:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 LEU A  57
TYR A  84
HIS A 119
ILE A 165
 None
 0.73A 2bu8A-1y8pA:
47.7		 2bu8A-1y8pA:
64.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		4 LEU A 425
ILE A 351
ILE A 382
ILE A 365
 None
 0.75A 2bu8A-1z3zA:
undetectable		 2bu8A-1z3zA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z87 ALPHA-1-SYNTROPHIN

(Mus musculus) 		PF00595
(PDZ) 		4 LEU A 123
ILE A 129
ILE A  94
ILE A  96
 LEU  A 123 ( 0.6A)
ILE  A 129 ( 0.6A)
ILE  A  94 ( 0.6A)
ILE  A  96 ( 0.6A)
 0.84A 2bu8A-1z87A:
undetectable		 2bu8A-1z87A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2d N-ACETYLGALACTOSAMIN
E KINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 LEU A 249
ILE A 315
ILE A 300
ILE A 306
 None
 0.80A 2bu8A-2a2dA:
undetectable		 2bu8A-2a2dA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be9 ASPARTATE
CARBAMOYLTRANSFERASE
REGULATORY CHAIN

(Sulfolobus
acidocaldarius) 		PF01948
(PyrI)
PF02748
(PyrI_C) 		4 LEU B  36
ILE B  21
ILE B  70
ILE B  87
 None
 0.81A 2bu8A-2be9B:
undetectable		 2bu8A-2be9B:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnk EARLY PROTEIN GP16.7

(Bacillus virus
phi29) 		PF06720
(Phi-29_GP16_7) 		4 LEU A  75
ILE A 108
ILE A  90
ILE A  89
 None
 0.78A 2bu8A-2bnkA:
undetectable		 2bu8A-2bnkA:
11.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bu2 PYRUVATE
DEHYDROGENSAE KINASE
ISOENZYME 2

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		8 LEU A  53
TYR A  80
ILE A 111
HIS A 115
ARG A 154
ILE A 157
ARG A 158
ILE A 161
 None
 0.17A 2bu8A-2bu2A:
52.2		 2bu8A-2bu2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dk8 DNA-DIRECTED RNA
POLYMERASE III 39
KDA POLYPEPTIDE

(Mus musculus) 		PF05158
(RNA_pol_Rpc34) 		5 LEU A  60
ILE A  30
ILE A  19
ARG A  18
ILE A  35
 None
 1.03A 2bu8A-2dk8A:
undetectable		 2bu8A-2dk8A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dnw ACYL CARRIER PROTEIN

(Homo sapiens) 		PF00550
(PP-binding) 		4 LEU A  24
ILE A  81
ILE A  55
ILE A  56
 None
 0.82A 2bu8A-2dnwA:
undetectable		 2bu8A-2dnwA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 LEU A 231
TYR A  81
ILE A 425
ILE A 234
ILE A 247
 None
 1.26A 2bu8A-2e0wA:
undetectable		 2bu8A-2e0wA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eax PEPTIDOGLYCAN
RECOGNITION
PROTEIN-I-BETA

(Homo sapiens) 		PF01510
(Amidase_2) 		4 LEU A 345
ILE A 330
ILE A 238
ILE A 307
 None
 0.81A 2bu8A-2eaxA:
undetectable		 2bu8A-2eaxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f31 DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		4 ILE A 208
ARG A 160
ARG A 210
ILE A 209
 None
 0.84A 2bu8A-2f31A:
undetectable		 2bu8A-2f31A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fez PROBABLE REGULATORY
PROTEIN EMBR

(Mycobacterium
tuberculosis) 		PF00486
(Trans_reg_C)
PF00498
(FHA)
PF03704
(BTAD) 		4 LEU A 292
TYR A 301
ILE A 310
ILE A 371
 None
 0.80A 2bu8A-2fezA:
1.8		 2bu8A-2fezA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2c PUTATIVE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN

(Corynebacterium
diphtheriae) 		PF00994
(MoCF_biosynth) 		4 LEU A  99
ILE A 157
ILE A 150
ILE A 154
 None
 0.83A 2bu8A-2g2cA:
undetectable		 2bu8A-2g2cA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN

(Thermotoga
maritima) 		PF13177
(DNA_pol3_delta2) 		5 LEU A  45
TYR A  92
ILE A  28
ARG A  90
ILE A  19
 None
 1.17A 2bu8A-2gnoA:
undetectable		 2bu8A-2gnoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN

(Thermotoga
maritima) 		PF13177
(DNA_pol3_delta2) 		5 LEU A  45
TYR A  92
ILE A  28
ILE A  20
ILE A  19
 None
 1.46A 2bu8A-2gnoA:
undetectable		 2bu8A-2gnoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsl HYPOTHETICAL PROTEIN

(Fusobacterium
nucleatum) 		PF00636
(Ribonuclease_3) 		4 LEU A  68
ILE A 121
ILE A 105
ILE A 106
 None
 0.76A 2bu8A-2gslA:
undetectable		 2bu8A-2gslA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ARG A 785
ILE A 788
ARG A 789
ILE A 792
 None
 0.50A 2bu8A-2gv9A:
undetectable		 2bu8A-2gv9A:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3m TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ) 		4 LEU A  95
ILE A 104
ILE A  38
ILE A  56
 None
 0.82A 2bu8A-2h3mA:
undetectable		 2bu8A-2h3mA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irw CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1

(Homo sapiens) 		PF00106
(adh_short) 		4 LEU A  54
ILE A 117
ILE A 246
ILE A 245
 None
 0.83A 2bu8A-2irwA:
undetectable		 2bu8A-2irwA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwq MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 LEU A1202
ILE A1208
ILE A1164
ILE A1166
 None
 0.82A 2bu8A-2iwqA:
undetectable		 2bu8A-2iwqA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jaq DEOXYGUANOSINE
KINASE

(Mycoplasma
mycoides) 		PF01712
(dNK) 		4 LEU A 131
ILE A 194
ILE A   5
ILE A  20
 None
 0.82A 2bu8A-2jaqA:
undetectable		 2bu8A-2jaqA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjx URIDYLATE KINASE

(Bacillus
anthracis) 		PF00696
(AA_kinase) 		4 LEU A  86
ILE A  36
ILE A 129
ILE A 127
 None
 0.84A 2bu8A-2jjxA:
undetectable		 2bu8A-2jjxA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kiv ANKYRIN REPEAT AND
STERILE ALPHA MOTIF
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF00536
(SAM_1) 		4 LEU A  20
ILE A  55
ILE A  44
ILE A  46
 None
 0.78A 2bu8A-2kivA:
undetectable		 2bu8A-2kivA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kiv ANKYRIN REPEAT AND
STERILE ALPHA MOTIF
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF00536
(SAM_1) 		4 TYR A  16
ILE A  44
ILE A  55
ARG A  52
 None
 0.83A 2bu8A-2kivA:
undetectable		 2bu8A-2kivA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nys AGR_C_3712P

(Agrobacterium
fabrum) 		PF04386
(SspB) 		4 LEU A  24
ILE A  41
ARG A  17
ILE A  97
 None
 0.75A 2bu8A-2nysA:
undetectable		 2bu8A-2nysA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		4 LEU A 186
ILE A 161
ILE A 175
ILE A 173
 None
 0.72A 2bu8A-2obmA:
undetectable		 2bu8A-2obmA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odh R.BCNI

(Brevibacillus
centrosporus) 		PF15515
(MvaI_BcnI) 		4 LEU A 148
ILE A 153
ILE A 188
ILE A 185
 ACT  A 239 (-4.5A)
None
None
None
 0.81A 2bu8A-2odhA:
undetectable		 2bu8A-2odhA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP

(Homo sapiens) 		PF01853
(MOZ_SAS) 		4 TYR A 365
ILE A 370
ILE A 398
ILE A 392
 None
 0.81A 2bu8A-2ou2A:
undetectable		 2bu8A-2ou2A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz6 VIRULENCE FACTOR
REGULATOR

(Pseudomonas
aeruginosa) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		5 TYR A  65
ILE A 172
ILE A 180
ARG A 179
ILE A 177
 None
 1.28A 2bu8A-2oz6A:
undetectable		 2bu8A-2oz6A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pdz SYNTROPHIN

(Mus musculus) 		PF00595
(PDZ) 		4 LEU A  45
ILE A  51
ILE A  16
ILE A  18
 None
 0.81A 2bu8A-2pdzA:
undetectable		 2bu8A-2pdzA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppq HOMOSERINE KINASE

(Agrobacterium
fabrum) 		PF01636
(APH) 		4 ARG A 167
ILE A 170
ARG A 171
ILE A 174
 None
 0.82A 2bu8A-2ppqA:
undetectable		 2bu8A-2ppqA:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		5 LEU A  87
TYR A 114
ARG A 188
ILE A 191
ARG A 192
 None
TF4  A 438 (-3.8A)
TF4  A 438 (-4.2A)
TF4  A 438 (-3.4A)
TF4  A 438 ( 4.8A)
 0.82A 2bu8A-2q8hA:
46.0		 2bu8A-2q8hA:
68.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		5 LEU A  87
TYR A 114
ILE A 145
ARG A 188
ILE A 191
 None
TF4  A 438 (-3.8A)
None
TF4  A 438 (-4.2A)
TF4  A 438 (-3.4A)
 0.61A 2bu8A-2q8hA:
46.0		 2bu8A-2q8hA:
68.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 480
ILE A 166
ILE A 483
ILE A 408
 None
 0.84A 2bu8A-2qyvA:
undetectable		 2bu8A-2qyvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va1 URIDYLATE KINASE

(Ureaplasma
parvum) 		PF00696
(AA_kinase) 		4 LEU A  84
ILE A  35
ILE A  10
ILE A   8
 None
 0.75A 2bu8A-2va1A:
undetectable		 2bu8A-2va1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc7 ALPHA AMYLASE,
CATALYTIC REGION

(Nostoc
punctiforme) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 LEU A 346
ILE A 354
HIS A 388
ILE A 392
ILE A  70
 None
 1.08A 2bu8A-2wc7A:
undetectable		 2bu8A-2wc7A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5q SSO1986

(Sulfolobus
solfataricus) 		no annotation 4 LEU A 158
TYR A 162
ILE A  83
ILE A  55
 None
 0.79A 2bu8A-2x5qA:
undetectable		 2bu8A-2x5qA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		4 ILE B 480
ILE B 569
ARG B 568
ILE B 478
 None
 0.84A 2bu8A-2xfgB:
undetectable		 2bu8A-2xfgB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhm NUCLEOPROTEIN

(Human
orthopneumovirus) 		PF03246
(Pneumo_ncap) 		4 LEU A  52
HIS A  59
ILE A 160
ILE A 163
 None
 0.84A 2bu8A-2yhmA:
undetectable		 2bu8A-2yhmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6i TRANS-2-ENOYL-ACP
REDUCTASE II

(Streptococcus
pneumoniae) 		PF03060
(NMO) 		4 LEU A   9
ILE A 114
ILE A   5
ILE A 166
 None
 0.83A 2bu8A-2z6iA:
undetectable		 2bu8A-2z6iA:
19.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 LEU A  65
TYR A  92
HIS A 127
ARG A 166
 None
 0.71A 2bu8A-2zkjA:
47.0		 2bu8A-2zkjA:
65.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Pyrococcus
horikoshii) 		PF09488
(Osmo_MPGsynth) 		5 LEU A 262
TYR A 277
ILE A 299
ARG A 281
ILE A 261
 None
 1.23A 2bu8A-2zu8A:
undetectable		 2bu8A-2zu8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE

(Methanocaldococcus
jannaschii) 		PF03587
(EMG1) 		4 LEU A 130
ILE A 171
ILE A 138
ILE A 140
 None
 0.66A 2bu8A-3bbhA:
undetectable		 2bu8A-3bbhA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A A SUBUNIT

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 LEU A  35
ILE A 408
ARG A  28
ILE A  32
ILE A 423
 None
 1.22A 2bu8A-3c5wA:
undetectable		 2bu8A-3c5wA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		4 LEU A  34
TYR A  37
ILE A  85
ILE A  86
 None
 0.77A 2bu8A-3ddhA:
undetectable		 2bu8A-3ddhA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1

(Cavia porcellus) 		PF00106
(adh_short) 		4 LEU A  54
ILE A 117
ILE A 246
ILE A 245
 None
 0.77A 2bu8A-3dwfA:
undetectable		 2bu8A-3dwfA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwm 9.5 KDA CULTURE
FILTRATE ANTIGEN
CFP10A

(Mycobacterium
tuberculosis) 		PF02597
(ThiS) 		4 ILE A  86
ARG A  45
ILE A  42
ILE A   7
 None
 0.78A 2bu8A-3dwmA:
undetectable		 2bu8A-3dwmA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e20 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Schizosaccharomyces
pombe) 		no annotation 4 LEU C  79
TYR C  82
ILE C  36
ILE C  92
 None
 0.66A 2bu8A-3e20C:
undetectable		 2bu8A-3e20C:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed5 YFNB

(Bacillus
subtilis) 		PF13419
(HAD_2) 		5 LEU A 227
TYR A   4
ILE A 179
ILE A 226
ILE A 217
 None
 1.01A 2bu8A-3ed5A:
undetectable		 2bu8A-3ed5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG

(Sulfolobus
solfataricus) 		PF01890
(CbiG_C)
PF11760
(CbiG_N) 		4 LEU A 117
ILE A  33
ILE A  17
ILE A  19
 None
 0.80A 2bu8A-3eeqA:
undetectable		 2bu8A-3eeqA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqe PUTATIVE CYSTEIN
DIOXYGENASE

(Bacillus
subtilis) 		PF05995
(CDO_I) 		4 LEU A   3
ILE A  29
ILE A   7
ILE A  10
 None
 0.85A 2bu8A-3eqeA:
undetectable		 2bu8A-3eqeA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etu PROTEIN TRANSPORT
PROTEIN DSL1

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		4 LEU A 233
ILE A 213
ILE A 224
ILE A 217
 None
 0.84A 2bu8A-3etuA:
undetectable		 2bu8A-3etuA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE

(Comamonas
testosteroni) 		PF00155
(Aminotran_1_2) 		4 LEU A 398
TYR A 109
ILE A 147
ILE A 143
 None
 0.85A 2bu8A-3fddA:
undetectable		 2bu8A-3fddA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffs INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00478
(IMPDH) 		4 LEU A  45
ILE A 261
ILE A 274
ILE A 255
 None
 0.85A 2bu8A-3ffsA:
undetectable		 2bu8A-3ffsA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1

(Schizosaccharomyces
pombe) 		PF04857
(CAF1) 		4 ILE A 222
ARG A 254
ILE A 251
ILE A 247
 None
 0.83A 2bu8A-3g10A:
undetectable		 2bu8A-3g10A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		4 LEU A 277
TYR A 300
ILE A 121
ILE A 203
 None
 0.79A 2bu8A-3gbzA:
undetectable		 2bu8A-3gbzA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0d CTSR

(Geobacillus
stearothermophilus) 		PF05848
(CtsR) 		4 LEU A  12
ILE A  42
ILE A  70
ILE A  68
 None
 0.80A 2bu8A-3h0dA:
undetectable		 2bu8A-3h0dA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A 160
ILE A 263
ILE A 178
ILE A 179
 None
 0.75A 2bu8A-3igoA:
undetectable		 2bu8A-3igoA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j70 ENVELOPE
GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 LEU D 483
TYR D 486
ILE D 251
ILE D 215
 None
 0.83A 2bu8A-3j70D:
undetectable		 2bu8A-3j70D:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF14

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		4 LEU e  23
ILE e  60
ILE e  19
ILE e  70
 None
 0.83A 2bu8A-3jb9e:
2.3		 2bu8A-3jb9e:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN

(Homo sapiens) 		PF00516
(GP120) 		4 LEU A 483
TYR A 486
ILE A 251
ILE A 215
 None
 0.67A 2bu8A-3jwoA:
undetectable		 2bu8A-3jwoA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke5 HYPOTHETICAL
CYTOSOLIC PROTEIN

(Bacillus cereus) 		PF01923
(Cob_adeno_trans) 		4 LEU A  59
ILE A 121
ILE A  55
ILE A 166
 None
 0.81A 2bu8A-3ke5A:
2.3		 2bu8A-3ke5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kip 3-DEHYDROQUINASE,
TYPE II

(Candida
albicans) 		PF01220
(DHquinase_II) 		4 LEU A  92
ILE A  76
ILE A  63
ILE A  59
 None
 0.83A 2bu8A-3kipA:
undetectable		 2bu8A-3kipA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks4 POLYMERASE COFACTOR
VP35

(Reston
ebolavirus) 		PF02097
(Filo_VP35) 		4 LEU A 231
ILE A 309
ILE A 235
ILE A 238
 None
 0.82A 2bu8A-3ks4A:
undetectable		 2bu8A-3ks4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2a POLYMERASE COFACTOR
VP35

(Reston
ebolavirus) 		PF02097
(Filo_VP35) 		4 LEU A 231
ILE A 309
ILE A 235
ILE A 238
 None
 0.79A 2bu8A-3l2aA:
undetectable		 2bu8A-3l2aA:
20.62