SIMILAR PATTERNS OF AMINO ACIDS FOR 2BTE_D_LEUD1893_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE

(Rattus rattus) 		PF01242
(PTPS) 		4 ASP A  93
SER A 104
TYR A  52
HIS A  48
 None
None
None
ZN  A 401 ( 3.4A)
 1.38A 2bteD-1b66A:
undetectable		 2bteD-1b66A:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 TYR A  35
ASP A  17
SER A  20
HIS A  24
 None
None
None
OXY  A 405 ( 4.8A)
 1.18A 2bteD-1e5dA:
2.4		 2bteD-1e5dA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		4 TYR A  38
ASP A  35
TYR A 170
TYR A 146
 None
 1.33A 2bteD-1eg1A:
undetectable		 2bteD-1eg1A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6o CAG-ALPHA

(Helicobacter
pylori) 		PF00437
(T2SSE) 		4 SER A 190
TYR A 187
TYR A 151
HIS A 142
 None
 1.27A 2bteD-1g6oA:
undetectable		 2bteD-1g6oA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 TYR A  50
SER A  35
TYR A 305
HIS A 263
 ACR  A 598 (-4.5A)
None
None
None
 1.35A 2bteD-1kxhA:
undetectable		 2bteD-1kxhA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		4 ASP A 208
SER A   7
TYR A 257
HIS A 309
 None
 1.28A 2bteD-1m2pA:
undetectable		 2bteD-1m2pA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5t TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 TYR A 420
ASP A 397
SER A 378
HIS A 387
 None
 1.04A 2bteD-1o5tA:
9.5		 2bteD-1o5tA:
17.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		7 MET A  40
TYR A  43
ASP A  80
SER A 504
TYR A 507
TYR A 535
HIS A 545
 LMS  A1817 ( 3.7A)
NVA  A1816 ( 3.5A)
NVA  A1816 (-3.9A)
NVA  A1816 ( 4.8A)
None
None
NVA  A1816 (-3.5A)
 0.48A 2bteD-1obhA:
38.9		 2bteD-1obhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		4 ASP A 188
SER A 184
TYR A 183
HIS A 273
 None
 1.34A 2bteD-1ocmA:
undetectable		 2bteD-1ocmA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE

(Candida
tropicalis) 		PF01575
(MaoC_dehydratas) 		4 MET A 206
ASP A 182
TYR A 177
HIS A  46
 None
HDC  A1277 (-2.8A)
None
None
 1.34A 2bteD-1pn4A:
undetectable		 2bteD-1pn4A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		4 MET A  82
TYR A  90
TYR A  93
HIS A 329
 None
 1.17A 2bteD-1wzaA:
undetectable		 2bteD-1wzaA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x79 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1

(Homo sapiens) 		PF03127
(GAT) 		4 MET A 249
ASP A 247
TYR A 294
HIS A 235
 None
 1.15A 2bteD-1x79A:
3.9		 2bteD-1x79A:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2x INTEGRIN ALPHA-1

(Rattus
norvegicus) 		PF00092
(VWA) 		4 MET A 225
ASP A 154
SER A 156
HIS A 261
 None
MG  A 400 (-3.2A)
MG  A 400 (-2.6A)
None
 1.34A 2bteD-2b2xA:
undetectable		 2bteD-2b2xA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		4 TYR A 608
ASP A 600
TYR A 692
HIS A 649
 None
 1.28A 2bteD-2cn3A:
undetectable		 2bteD-2cn3A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exh BETA-D-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43) 		4 ASP A 479
SER A 477
TYR A 462
TYR A 529
 None
 1.36A 2bteD-2exhA:
undetectable		 2bteD-2exhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 TYR A 630
SER A 439
TYR A 269
HIS A 155
 None
GOL  A 778 ( 4.3A)
None
GOL  A 778 (-4.3A)
 1.33A 2bteD-2f3oA:
undetectable		 2bteD-2f3oA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE

(Caenorhabditis
elegans) 		PF01242
(PTPS) 		4 ASP A  88
SER A  99
TYR A  48
HIS A  44
 None
None
None
ZN  A2001 ( 3.3A)
 1.37A 2bteD-2g64A:
undetectable		 2bteD-2g64A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Gallus gallus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 MET A 367
ASP A 246
SER A 402
TYR A 365
 None
None
None
FAD  A1001 ( 4.2A)
 1.38A 2bteD-2h88A:
undetectable		 2bteD-2h88A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hbw NLP/P60 PROTEIN

(Trichormus
variabilis) 		PF00877
(NLPC_P60) 		4 TYR A 114
ASP A 125
SER A 127
HIS A 176
 ACT  A 236 (-4.2A)
UNL  A 237 (-3.8A)
UNL  A 237 (-2.6A)
ACT  A 236 (-3.7A)
 1.35A 2bteD-2hbwA:
undetectable		 2bteD-2hbwA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdw HYPOTHETICAL PROTEIN
PA2218

(Pseudomonas
aeruginosa) 		PF02129
(Peptidase_S15) 		4 ASP A 262
TYR A 263
TYR A 204
HIS A 318
 None
 0.94A 2bteD-2hdwA:
undetectable		 2bteD-2hdwA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htb PUTATIVE ENZYME
RELATED TO ALDOSE
1-EPIMERASE

(Salmonella
enterica) 		PF01263
(Aldose_epim) 		4 ASP A 208
TYR A 166
HIS A  95
HIS A 164
 None
 1.37A 2bteD-2htbA:
undetectable		 2bteD-2htbA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
T-CELL RECEPTOR BETA
CHAIN V

(Mycoplasma
arthritidis;
Mus musculus) 		PF09245
(MA-Mit)
PF07686
(V-set) 		4 SER J  93
TYR J 100
TYR G 188
HIS J  29
 None
 1.32A 2bteD-2icwJ:
undetectable		 2bteD-2icwJ:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
T-CELL RECEPTOR BETA
CHAIN V

(Mycoplasma
arthritidis;
Mus musculus) 		PF09245
(MA-Mit)
PF07686
(V-set) 		4 TYR J  33
TYR J 100
TYR G 188
HIS J  29
 None
 1.34A 2bteD-2icwJ:
undetectable		 2bteD-2icwJ:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 MET A 138
SER A 287
TYR A 290
TYR A  81
 None
 1.08A 2bteD-2j3hA:
2.3		 2bteD-2j3hA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzd REPLICASE
POLYPROTEIN 1AB

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11633
(SUD-M) 		4 ASP A 552
SER A 585
TYR A 583
HIS A 613
 None
 1.23A 2bteD-2jzdA:
undetectable		 2bteD-2jzdA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqh PUTATIVE ISOMERASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 197
TYR A 221
HIS A 297
HIS A 268
 None
 1.21A 2bteD-2oqhA:
undetectable		 2bteD-2oqhA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybr SINGLE CHAIN
ANTIBODY FRAGMENT
9004G
BETA-MAMMAL TOXIN
CN2

(Homo sapiens;
Centruroides
noxius) 		PF07686
(V-set)
PF00537
(Toxin_3) 		4 ASP B 182
SER B 163
TYR B 164
TYR C  42
 None
 1.36A 2bteD-2ybrB:
undetectable		 2bteD-2ybrB:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 TYR A 349
ASP A 208
SER A 194
HIS A 603
 None
None
None
ZN  A1637 ( 3.2A)
 1.38A 2bteD-2ycbA:
undetectable		 2bteD-2ycbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 MET A1012
ASP A 613
TYR A 651
TYR A 654
 None
 1.37A 2bteD-3bg9A:
undetectable		 2bteD-3bg9A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwg UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YYDK

(Bacillus
subtilis) 		PF00392
(GntR)
PF07702
(UTRA) 		4 TYR A 141
ASP A 214
SER A 216
TYR A 215
 None
 1.35A 2bteD-3bwgA:
undetectable		 2bteD-3bwgA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		4 TYR A  64
ASP A  59
SER A  39
HIS A  35
 None
 1.06A 2bteD-3ck2A:
undetectable		 2bteD-3ck2A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d23 3C-LIKE PROTEINASE

(Human
coronavirus
HKU1) 		no annotation 4 SER B 144
TYR B 161
HIS B 172
HIS B 163
 None
 1.34A 2bteD-3d23B:
undetectable		 2bteD-3d23B:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d62 3C-LIKE PROTEINASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF05409
(Peptidase_C30) 		4 SER A 144
TYR A 161
HIS A 172
HIS A 163
 959  A 350 ( 4.4A)
None
None
None
 1.33A 2bteD-3d62A:
undetectable		 2bteD-3d62A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e74 ALLANTOINASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 ASP A  57
SER A 314
TYR A 406
HIS A 316
 None
 1.29A 2bteD-3e74A:
undetectable		 2bteD-3e74A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn9 PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 SER A 590
TYR A 594
TYR A 504
HIS A 537
 None
 1.14A 2bteD-3fn9A:
undetectable		 2bteD-3fn9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00579
(tRNA-synt_1b) 		4 TYR A 382
ASP A 359
SER A 340
HIS A 349
 None
 1.02A 2bteD-3focA:
5.3		 2bteD-3focA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 ASP A 255
SER A 254
TYR A 297
HIS A 239
 None
None
None
MLA  A 302 ( 3.5A)
 1.22A 2bteD-3fssA:
undetectable		 2bteD-3fssA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvr ACETYL XYLAN
ESTERASE

(Bacillus
pumilus) 		PF05448
(AXE1) 		4 ASP A 249
SER A 208
TYR A  14
HIS A 283
 None
 1.38A 2bteD-3fvrA:
undetectable		 2bteD-3fvrA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9a MINIMIZER

(Camelus
dromedarius) 		PF07686
(V-set) 		4 MET B  34
TYR B 102
ASP B 101
SER B  96
 None
 1.33A 2bteD-3g9aB:
undetectable		 2bteD-3g9aB:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 TYR A 161
SER A 164
TYR A 109
HIS A 152
 None
 1.21A 2bteD-3gm8A:
undetectable		 2bteD-3gm8A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 TYR A  94
TYR A  36
HIS A  53
HIS A 108
 None
 1.25A 2bteD-3h3zA:
undetectable		 2bteD-3h3zA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm7 ALLANTOINASE

(Bacillus
halodurans) 		PF01979
(Amidohydro_1) 		4 ASP A  61
SER A 314
TYR A 408
HIS A 316
 None
 1.29A 2bteD-3hm7A:
undetectable		 2bteD-3hm7A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzr TRYPTOPHANYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00579
(tRNA-synt_1b) 		4 TYR A 335
ASP A 312
SER A 293
HIS A 302
 None
 1.05A 2bteD-3hzrA:
9.5		 2bteD-3hzrA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		4 TYR A 145
SER A 104
TYR A 121
HIS A 142
 None
AAE  A 501 (-2.5A)
None
None
 1.25A 2bteD-3i09A:
undetectable		 2bteD-3i09A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE

(Homo sapiens) 		PF01242
(PTPS) 		4 ASP A  94
SER A 105
TYR A  53
HIS A  49
 None
None
None
NI  A 146 (-3.1A)
 1.35A 2bteD-3i2bA:
undetectable		 2bteD-3i2bA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Pectobacterium
atrosepticum) 		PF00155
(Aminotran_1_2) 		4 SER A 235
TYR A 264
HIS A 103
HIS A 104
 None
EDO  A   2 (-4.8A)
EDO  A   2 ( 4.4A)
None
 1.05A 2bteD-3ly1A:
undetectable		 2bteD-3ly1A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4f ENDO-1,4-BETA-XYLANA
SE

(Acidomyces
acidophilus) 		PF00457
(Glyco_hydro_11) 		4 ASP A 127
SER A 126
TYR A 131
HIS A 171
 CXS  A 207 (-3.6A)
CXS  A 207 (-3.4A)
None
None
 1.35A 2bteD-3m4fA:
undetectable		 2bteD-3m4fA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7o LYMPHOCYTE ANTIGEN
86

(Mus musculus) 		PF02221
(E1_DerP2_DerF2) 		4 TYR A 145
ASP A  84
SER A  98
TYR A  97
 BEN  A 165 (-3.4A)
BEN  A 163 ( 3.2A)
BEN  A 163 ( 3.4A)
L9R  A 301 ( 3.5A)
 0.95A 2bteD-3m7oA:
undetectable		 2bteD-3m7oA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00342
(PGI) 		4 TYR A  40
ASP A  42
SER A  44
TYR A  43
 None
 1.20A 2bteD-3q88A:
undetectable		 2bteD-3q88A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s99 BASIC MEMBRANE
LIPOPROTEIN

(Brucella
abortus) 		PF02608
(Bmp) 		4 TYR A  91
TYR A 122
TYR A 253
HIS A  40
 None
 1.26A 2bteD-3s99A:
1.8		 2bteD-3s99A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tze TRYPTOPHANYL-TRNA
SYNTHETASE

(Encephalitozoon
cuniculi) 		PF00579
(tRNA-synt_1b) 		4 TYR A 339
ASP A 316
SER A 297
TYR A 296
 None
 1.07A 2bteD-3tzeA:
4.3		 2bteD-3tzeA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3i NUCLEOCAPSID PROTEIN

(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 SER A 309
TYR A 312
TYR A 110
HIS A 376
 None
 1.28A 2bteD-3u3iA:
undetectable		 2bteD-3u3iA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzm ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		4 ASP A 101
SER A 100
TYR A 105
HIS A 149
 None
 1.38A 2bteD-3vzmA:
undetectable		 2bteD-3vzmA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 4 MET A 161
ASP A 167
HIS A 143
HIS A 140
 None
 1.27A 2bteD-3w36A:
undetectable		 2bteD-3w36A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmy EXTRACELLULAR
EXO-ALPHA-L-ARABINOF
URANOSIDASE

(Streptomyces
coelicolor) 		PF03664
(Glyco_hydro_62) 		4 SER A 217
TYR A 224
TYR A 461
HIS A 427
 TRS  A 503 ( 4.5A)
TRS  A 503 (-3.8A)
TRS  A 503 (-4.9A)
CA  A 501 ( 3.6A)
 1.26A 2bteD-3wmyA:
undetectable		 2bteD-3wmyA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdn MONOAMINE OXIDASE N

(Aspergillus
niger) 		PF01593
(Amino_oxidase) 		4 MET A 233
ASP A 468
SER A 100
HIS A 172
 None
 1.30A 2bteD-3zdnA:
undetectable		 2bteD-3zdnA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhb R-IMINE REDUCTASE

(Streptomyces
kanamyceticus) 		PF03446
(NAD_binding_2) 		4 ASP A 130
SER A 157
TYR A 175
HIS A 180
 None
 1.37A 2bteD-3zhbA:
2.5		 2bteD-3zhbA:
18.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		8 MET A  43
TYR A  46
ASP A  84
SER A 324
TYR A 327
TYR A 361
HIS A 367
HIS A 371
 LSS  A1638 (-3.9A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 ( 3.9A)
LSS  A1638 (-4.8A)
None
LSS  A1638 (-3.8A)
LSS  A1638 (-3.7A)
 0.46A 2bteD-3ziuA:
37.4		 2bteD-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 TYR A 327
TYR A  46
HIS A 371
HIS A 367
 LSS  A1638 (-4.8A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 0.92A 2bteD-3ziuA:
37.4		 2bteD-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 TYR A 361
TYR A  46
HIS A 371
HIS A 367
 None
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 1.33A 2bteD-3ziuA:
37.4		 2bteD-3ziuA:
32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		4 TYR A 489
TYR A 283
TYR A 296
HIS A 535
 None
 1.28A 2bteD-4aeeA:
undetectable		 2bteD-4aeeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		4 ASP A 153
SER A 182
TYR A 185
HIS A 146
 None
None
None
ZN  A 999 ( 3.3A)
 1.25A 2bteD-4aigA:
undetectable		 2bteD-4aigA:
11.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		8 MET A  40
TYR A  43
ASP A  80
SER A 496
TYR A 499
TYR A 527
HIS A 533
HIS A 537
 LEU  A1001 ( 4.3A)
LEU  A1001 (-3.5A)
LEU  A1001 (-3.9A)
LEU  A1001 ( 3.7A)
None
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.63A 2bteD-4arcA:
34.1		 2bteD-4arcA:
45.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asl EPA1P

([Candida]
glabrata) 		PF10528
(GLEYA) 		4 ASP A  69
SER A  67
TYR A  68
TYR A  88
 NA  A 304 (-3.1A)
None
None
None
 1.13A 2bteD-4aslA:
undetectable		 2bteD-4aslA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b29 DIMETHYLSULFONIOPROP
IONATE LYASE

(Roseovarius
nubinhibens) 		PF16867
(DMSP_lyase) 		4 ASP A 191
SER A  80
TYR A  81
TYR A 124
 None
None
None
PO4  A1197 (-4.6A)
 1.31A 2bteD-4b29A:
undetectable		 2bteD-4b29A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4coy EPITHELIAL ADHESIN 6

([Candida]
glabrata) 		PF10528
(GLEYA) 		4 ASP A  69
SER A  67
TYR A  68
TYR A  88
 ACT  A1273 (-3.3A)
ACT  A1273 (-2.6A)
None
None
 1.15A 2bteD-4coyA:
undetectable		 2bteD-4coyA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e51 HISTIDINE--TRNA
LIGASE

(Burkholderia
thailandensis) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 SER A 368
TYR A 337
HIS A 340
HIS A 366
 None
 1.08A 2bteD-4e51A:
undetectable		 2bteD-4e51A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 4 SER A 382
TYR A 480
HIS A 412
HIS A 383
 None
 1.18A 2bteD-4ecoA:
undetectable		 2bteD-4ecoA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Ruegeria sp.
TM1040) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 381
SER A 189
TYR A  32
HIS A 386
 None
None
GOL  A 501 (-4.5A)
None
 1.38A 2bteD-4ip4A:
undetectable		 2bteD-4ip4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		4 ASP A 230
SER A 272
TYR A 317
HIS A 308
 None
 1.37A 2bteD-4n0rA:
2.5		 2bteD-4n0rA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo2 CHLOROPHENOL-4-MONOO
XYGENASE

(Streptomyces
globisporus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ASP A 122
SER A 120
TYR A 123
TYR A 465
 None
 1.29A 2bteD-4oo2A:
undetectable		 2bteD-4oo2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE

(Entamoeba
histolytica) 		PF00459
(Inositol_P) 		4 TYR A 212
SER A 219
TYR A 248
HIS A 258
 None
 1.34A 2bteD-4qxdA:
undetectable		 2bteD-4qxdA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmd ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF05409
(Peptidase_C30) 		4 SER A 147
TYR A 164
HIS A 175
HIS A 166
 PGE  A 402 ( 3.9A)
None
None
PGE  A 402 (-4.6A)
 1.32A 2bteD-4wmdA:
undetectable		 2bteD-4wmdA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz8 NUCLEOPROTEIN

(Thiafora
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 SER A 304
TYR A 307
TYR A 114
HIS A 371
 None
 1.32A 2bteD-4xz8A:
undetectable		 2bteD-4xz8A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzc NUCLEOPROTEIN

(Nairobi sheep
disease
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 SER A 310
TYR A 313
TYR A 110
HIS A 377
 None
 1.24A 2bteD-4xzcA:
2.8		 2bteD-4xzcA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xze NUCLEOPROTEIN

(Hazara
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 SER A 312
TYR A 315
TYR A 112
HIS A 379
 None
 1.19A 2bteD-4xzeA:
undetectable		 2bteD-4xzeA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ASP A  68
SER A  63
TYR A  96
HIS A 131
 None
 1.22A 2bteD-4zo6A:
undetectable		 2bteD-4zo6A:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		8 MET A  38
TYR A  41
ASP A  78
SER A 493
TYR A 496
TYR A 523
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.33A 2bteD-5ah5A:
39.7		 2bteD-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		4 TYR A 496
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 0.87A 2bteD-5ah5A:
39.7		 2bteD-5ah5A:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqs ELONGATION FACTOR
1-BETA

(Homo sapiens) 		no annotation 4 SER D  61
TYR D  62
TYR D  24
HIS D  58
 None
 1.33A 2bteD-5dqsD:
undetectable		 2bteD-5dqsD:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia annua) 		PF00724
(Oxidored_FMN) 		4 ASP A 188
SER A 234
HIS A 239
HIS A 183
 None
None
None
FMN  A7401 (-4.5A)
 1.33A 2bteD-5dxxA:
undetectable		 2bteD-5dxxA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i33 ADENYLOSUCCINATE
SYNTHETASE

(Cryptococcus
neoformans) 		PF00709
(Adenylsucc_synt) 		4 TYR A 237
ASP A 234
SER A 249
TYR A 329
 None
 1.28A 2bteD-5i33A:
undetectable		 2bteD-5i33A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqk BETA-LACTAMASE RM3

(uncultured
bacterium) 		PF00753
(Lactamase_B) 		4 ASP A  77
SER A 107
TYR A 284
HIS A 254
 None
None
None
ZN  A 402 (-3.2A)
 1.31A 2bteD-5iqkA:
undetectable		 2bteD-5iqkA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER

(Prochlorococcus
marinus) 		no annotation 4 TYR A 206
ASP A 205
SER A 128
TYR A 203
 GB  A 401 (-3.2A)
GB  A 401 (-2.7A)
GB  A 401 (-2.7A)
None
 1.26A 2bteD-5lq8A:
undetectable		 2bteD-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER

(Prochlorococcus
marinus) 		no annotation 4 TYR A 206
ASP A 205
TYR A 203
HIS A 158
 GB  A 401 (-3.2A)
GB  A 401 (-2.7A)
None
GB  A 401 (-4.0A)
 1.31A 2bteD-5lq8A:
undetectable		 2bteD-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		4 MET B  72
TYR B  80
TYR B  83
HIS B 304
 None
None
K  B 605 ( 3.2A)
None
 1.07A 2bteD-5m99B:
2.5		 2bteD-5m99B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C)
PF04616
(Glyco_hydro_43) 		4 ASP A 413
SER A 411
TYR A 442
TYR A 330
 None
 1.21A 2bteD-5msxA:
undetectable		 2bteD-5msxA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 ASP A 671
SER A 636
TYR A 634
TYR A 855
 None
 1.38A 2bteD-5n4lA:
undetectable		 2bteD-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odb D10 FAB FRAGMENT -
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 TYR A 107
ASP A  33
SER A  52
TYR A  53
 None
 1.25A 2bteD-5odbA:
undetectable		 2bteD-5odbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 4 ASP A 636
SER A 634
TYR A 188
HIS A 546
 None
 1.26A 2bteD-5opqA:
undetectable		 2bteD-5opqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 4 MET A  23
ASP A  19
TYR A  27
HIS A 589
 None
 1.23A 2bteD-5oynA:
undetectable		 2bteD-5oynA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum) 		no annotation 4 TYR A  38
ASP A  35
TYR A 170
TYR A 146
 TYR  A  38 ( 1.3A)
ASP  A  35 ( 0.6A)
TYR  A 170 ( 1.3A)
TYR  A 146 ( 1.3A)
 1.32A 2bteD-5w0aA:
undetectable		 2bteD-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x18 CASEIN KINASE I
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 MET A 258
ASP A 256
TYR A 331
HIS A 180
 None
 1.18A 2bteD-5x18A:
undetectable		 2bteD-5x18A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqj BETA-XYLOSIDASE

(Bacillus
pumilus) 		no annotation 4 ASP A 477
SER A 475
TYR A 460
TYR A 527
 None
 1.33A 2bteD-5zqjA:
undetectable		 2bteD-5zqjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0t FASCIN

(Homo sapiens) 		no annotation 4 TYR A  23
SER A 410
TYR A 411
TYR A 186
 None
 1.34A 2bteD-6b0tA:
undetectable		 2bteD-6b0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 4 TYR A 110
ASP A 312
SER A 308
TYR A  73
 None
 1.12A 2bteD-6c6lA:
2.1		 2bteD-6c6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE

(Homo sapiens) 		no annotation 4 TYR A 210
SER A 251
TYR A 255
TYR A  60
 None
PO4  A 601 ( 4.0A)
None
None
 1.07A 2bteD-6dd3A:
undetectable		 2bteD-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e0s -

(-) 		no annotation 4 ASP A  60
SER A  90
TYR A 267
HIS A 237
 None
None
None
ZN  A 302 (-4.3A)
 1.36A 2bteD-6e0sA:
undetectable		 2bteD-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoq DIPEPTIDYL PEPTIDASE
9

(Homo sapiens) 		no annotation 4 TYR A 762
ASP A 763
HIS A 815
HIS A 812
 None
 1.24A 2bteD-6eoqA:
undetectable		 2bteD-6eoqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f79 -

(-) 		no annotation 4 ASP A 260
TYR A 149
HIS A  69
HIS A  68
 0X9  A 407 (-4.3A)
None
ZN  A 401 ( 3.1A)
None
 1.21A 2bteD-6f79A:
1.4		 2bteD-6f79A:
undetectable