SIMILAR PATTERNS OF AMINO ACIDS FOR 2BTE_A_LEUA1894

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amu GRAMICIDIN
SYNTHETASE 1

(Brevibacillus
brevis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 TYR A 123
ASP A 120
SER A 231
TYR A 116
 None
 1.20A 2bteA-1amuA:
undetectable		 2bteA-1amuA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 TYR A  35
ASP A  17
SER A  20
HIS A  24
 None
None
None
OXY  A 405 ( 4.8A)
 1.10A 2bteA-1e5dA:
2.5		 2bteA-1e5dA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		4 TYR A  38
ASP A  35
TYR A 170
TYR A 146
 None
 1.36A 2bteA-1eg1A:
undetectable		 2bteA-1eg1A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		4 ASP A 153
SER A 182
TYR A 185
HIS A 146
 None
None
None
ZN  A 401 ( 3.2A)
 1.25A 2bteA-1htdA:
0.4		 2bteA-1htdA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		4 ASP A 155
SER A 183
TYR A 186
HIS A 144
 None
None
None
CD  A 981 (-3.5A)
 1.22A 2bteA-1kugA:
1.0		 2bteA-1kugA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 TYR A  50
SER A  35
TYR A 305
HIS A 263
 ACR  A 598 (-4.5A)
None
None
None
 1.36A 2bteA-1kxhA:
0.0		 2bteA-1kxhA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5t TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 TYR A 420
ASP A 397
SER A 378
HIS A 387
 None
 1.09A 2bteA-1o5tA:
0.0		 2bteA-1o5tA:
17.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		7 MET A  40
TYR A  43
ASP A  80
SER A 504
TYR A 507
TYR A 535
HIS A 545
 LMS  A1817 ( 3.7A)
NVA  A1816 ( 3.5A)
NVA  A1816 (-3.9A)
NVA  A1816 ( 4.8A)
None
None
NVA  A1816 (-3.5A)
 0.50A 2bteA-1obhA:
38.5		 2bteA-1obhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE

(Candida
tropicalis) 		PF01575
(MaoC_dehydratas) 		4 MET A 206
ASP A 182
TYR A 177
HIS A  46
 None
HDC  A1277 (-2.8A)
None
None
 1.36A 2bteA-1pn4A:
undetectable		 2bteA-1pn4A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvj PYROGENIC EXOTOXIN B

(Streptococcus
pyogenes) 		PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69) 		4 MET A 274
SER A 271
TYR A 216
TYR A 276
 None
 1.19A 2bteA-1pvjA:
undetectable		 2bteA-1pvjA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tfd TRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		4 SER A 248
TYR A  95
TYR A 188
HIS A 249
 None
FE  A 950 ( 4.3A)
CO3  A 900 ( 3.6A)
FE  A 950 ( 3.4A)
 1.29A 2bteA-1tfdA:
undetectable		 2bteA-1tfdA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 ASP A 325
SER A 327
TYR A 326
HIS A 362
 None
 1.20A 2bteA-1u08A:
undetectable		 2bteA-1u08A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfd LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 SER A 252
TYR A  92
TYR A 192
HIS A 253
 None
FE  A 400 (-4.1A)
CO3  A 401 (-3.8A)
FE  A 400 (-3.1A)
 1.35A 2bteA-1vfdA:
undetectable		 2bteA-1vfdA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		4 MET A  82
TYR A  90
TYR A  93
HIS A 329
 None
 1.15A 2bteA-1wzaA:
undetectable		 2bteA-1wzaA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x79 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1

(Homo sapiens) 		PF03127
(GAT) 		4 MET A 249
ASP A 247
TYR A 294
HIS A 235
 None
 1.25A 2bteA-1x79A:
5.3		 2bteA-1x79A:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		4 TYR A 158
SER A 103
TYR A 191
HIS A 146
 None
 1.12A 2bteA-2bi3A:
undetectable		 2bteA-2bi3A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		4 TYR A 608
ASP A 600
TYR A 692
HIS A 649
 None
 1.22A 2bteA-2cn3A:
undetectable		 2bteA-2cn3A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2evr COG0791: CELL
WALL-ASSOCIATED
HYDROLASES
(INVASION-ASSOCIATED
PROTEINS)

(Nostoc
punctiforme) 		PF00877
(NLPC_P60) 		4 TYR A 114
ASP A 125
SER A 127
HIS A 176
 None
 1.34A 2bteA-2evrA:
undetectable		 2bteA-2evrA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hbw NLP/P60 PROTEIN

(Trichormus
variabilis) 		PF00877
(NLPC_P60) 		4 TYR A 114
ASP A 125
SER A 127
HIS A 176
 ACT  A 236 (-4.2A)
UNL  A 237 (-3.8A)
UNL  A 237 (-2.6A)
ACT  A 236 (-3.7A)
 1.29A 2bteA-2hbwA:
undetectable		 2bteA-2hbwA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdw HYPOTHETICAL PROTEIN
PA2218

(Pseudomonas
aeruginosa) 		PF02129
(Peptidase_S15) 		4 ASP A 262
TYR A 263
TYR A 204
HIS A 318
 None
 1.08A 2bteA-2hdwA:
undetectable		 2bteA-2hdwA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
T-CELL RECEPTOR BETA
CHAIN V

(Mycoplasma
arthritidis;
Mus musculus) 		PF09245
(MA-Mit)
PF07686
(V-set) 		4 SER J  93
TYR J 100
TYR G 188
HIS J  29
 None
 1.35A 2bteA-2icwJ:
undetectable		 2bteA-2icwJ:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
T-CELL RECEPTOR BETA
CHAIN V

(Mycoplasma
arthritidis;
Mus musculus) 		PF09245
(MA-Mit)
PF07686
(V-set) 		4 TYR J  33
TYR J 100
TYR G 188
HIS J  29
 None
 1.32A 2bteA-2icwJ:
undetectable		 2bteA-2icwJ:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 MET A 138
SER A 287
TYR A 290
TYR A  81
 None
 1.15A 2bteA-2j3hA:
2.5		 2bteA-2j3hA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k1g LIPOPROTEIN SPR

(Escherichia
coli) 		PF00877
(NLPC_P60) 		4 TYR A  56
ASP A  67
SER A  69
HIS A 119
 None
 1.23A 2bteA-2k1gA:
undetectable		 2bteA-2k1gA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqh PUTATIVE ISOMERASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 197
TYR A 221
HIS A 297
HIS A 268
 None
 1.19A 2bteA-2oqhA:
undetectable		 2bteA-2oqhA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 TYR A 128
ASP A 106
SER A 108
TYR A 136
 None
 1.30A 2bteA-2z81A:
undetectable		 2bteA-2z81A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ady DOTD

(Legionella
pneumophila) 		PF16816
(DotD) 		4 ASP A 136
SER A 144
TYR A 148
HIS A 146
 None
 1.35A 2bteA-3adyA:
undetectable		 2bteA-3adyA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ck2 CONSERVED
UNCHARACTERIZED
PROTEIN (PREDICTED
PHOSPHOESTERASE
COG0622)

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		4 TYR A  64
ASP A  59
SER A  39
HIS A  35
 None
 1.06A 2bteA-3ck2A:
undetectable		 2bteA-3ck2A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d62 3C-LIKE PROTEINASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF05409
(Peptidase_C30) 		4 SER A 144
TYR A 161
HIS A 172
HIS A 163
 959  A 350 ( 4.4A)
None
None
None
 1.30A 2bteA-3d62A:
undetectable		 2bteA-3d62A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e74 ALLANTOINASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 ASP A  57
SER A 314
TYR A 406
HIS A 316
 None
 1.36A 2bteA-3e74A:
undetectable		 2bteA-3e74A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fez UNCHARACTERIZED
FERREDOXIN FOLD
PROTEIN RELATED TO
ANTIBIOTIC
BIOSYNTHESIS
MONOOXYGENASES

(Listeria
monocytogenes) 		no annotation 4 TYR A 157
ASP A 155
TYR A  72
TYR A  53
 None
 1.03A 2bteA-3fezA:
undetectable		 2bteA-3fezA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00579
(tRNA-synt_1b) 		4 TYR A 382
ASP A 359
SER A 340
HIS A 349
 None
 1.07A 2bteA-3focA:
4.0		 2bteA-3focA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 ASP A 255
SER A 254
TYR A 297
HIS A 239
 None
None
None
MLA  A 302 ( 3.5A)
 1.18A 2bteA-3fssA:
undetectable		 2bteA-3fssA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9a MINIMIZER

(Camelus
dromedarius) 		PF07686
(V-set) 		4 MET B  34
TYR B 102
ASP B 101
SER B  96
 None
 1.27A 2bteA-3g9aB:
undetectable		 2bteA-3g9aB:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Giardia
intestinalis) 		PF01116
(F_bP_aldolase) 		4 MET A   9
SER A 303
TYR A  18
TYR A 310
 None
 1.23A 2bteA-3gayA:
undetectable		 2bteA-3gayA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs9 PROTEIN GP18

(Listeria
monocytogenes) 		PF06605
(Prophage_tail) 		4 TYR A 266
ASP A 265
SER A 230
TYR A 228
 None
None
None
MLY  A 260 ( 3.9A)
 1.34A 2bteA-3gs9A:
undetectable		 2bteA-3gs9A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzr TRYPTOPHANYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00579
(tRNA-synt_1b) 		4 TYR A 335
ASP A 312
SER A 293
HIS A 302
 None
 1.08A 2bteA-3hzrA:
9.0		 2bteA-3hzrA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		4 TYR A 145
SER A 104
TYR A 121
HIS A 142
 None
AAE  A 501 (-2.5A)
None
None
 1.25A 2bteA-3i09A:
undetectable		 2bteA-3i09A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lb9 ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		4 ASP A 166
SER A 165
TYR A 170
HIS A  28
 None
 1.36A 2bteA-3lb9A:
undetectable		 2bteA-3lb9A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7o LYMPHOCYTE ANTIGEN
86

(Mus musculus) 		PF02221
(E1_DerP2_DerF2) 		4 TYR A 145
ASP A  84
SER A  98
TYR A  97
 BEN  A 165 (-3.4A)
BEN  A 163 ( 3.2A)
BEN  A 163 ( 3.4A)
L9R  A 301 ( 3.5A)
 0.95A 2bteA-3m7oA:
undetectable		 2bteA-3m7oA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng0 GLUTAMINE SYNTHETASE

(Synechocystis
sp. PCC 6803) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 MET A  68
ASP A  53
SER A  55
TYR A 103
 None
 1.33A 2bteA-3ng0A:
undetectable		 2bteA-3ng0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p94 GDSL-LIKE LIPASE

(Parabacteroides
distasonis) 		PF13472
(Lipase_GDSL_2) 		4 TYR A 181
ASP A 183
SER A 186
HIS A 185
 None
 1.28A 2bteA-3p94A:
undetectable		 2bteA-3p94A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5

(Thermotoga
petrophila) 		PF00150
(Cellulase) 		4 MET A  89
ASP A  77
TYR A 168
HIS A  48
 None
 1.16A 2bteA-3pz9A:
undetectable		 2bteA-3pz9A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00342
(PGI) 		4 TYR A  40
ASP A  42
SER A  44
TYR A  43
 None
 1.19A 2bteA-3q88A:
undetectable		 2bteA-3q88A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tze TRYPTOPHANYL-TRNA
SYNTHETASE

(Encephalitozoon
cuniculi) 		PF00579
(tRNA-synt_1b) 		4 TYR A 339
ASP A 316
SER A 297
TYR A 296
 None
 1.11A 2bteA-3tzeA:
8.9		 2bteA-3tzeA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzm ENDO-1,4-BETA-XYLANA
SE

(Bacillus
circulans) 		PF00457
(Glyco_hydro_11) 		4 ASP A 101
SER A 100
TYR A 105
HIS A 149
 None
 1.34A 2bteA-3vzmA:
undetectable		 2bteA-3vzmA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 4 MET A 161
ASP A 167
HIS A 143
HIS A 140
 None
 1.26A 2bteA-3w36A:
undetectable		 2bteA-3w36A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmy EXTRACELLULAR
EXO-ALPHA-L-ARABINOF
URANOSIDASE

(Streptomyces
coelicolor) 		PF03664
(Glyco_hydro_62) 		4 SER A 217
TYR A 224
TYR A 461
HIS A 427
 TRS  A 503 ( 4.5A)
TRS  A 503 (-3.8A)
TRS  A 503 (-4.9A)
CA  A 501 ( 3.6A)
 1.20A 2bteA-3wmyA:
undetectable		 2bteA-3wmyA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdn MONOAMINE OXIDASE N

(Aspergillus
niger) 		PF01593
(Amino_oxidase) 		4 MET A 233
ASP A 468
SER A 100
HIS A 172
 None
 1.33A 2bteA-3zdnA:
undetectable		 2bteA-3zdnA:
19.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		8 MET A  43
TYR A  46
ASP A  84
SER A 324
TYR A 327
TYR A 361
HIS A 367
HIS A 371
 LSS  A1638 (-3.9A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 ( 3.9A)
LSS  A1638 (-4.8A)
None
LSS  A1638 (-3.8A)
LSS  A1638 (-3.7A)
 0.41A 2bteA-3ziuA:
44.0		 2bteA-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 TYR A 327
TYR A  46
HIS A 371
HIS A 367
 LSS  A1638 (-4.8A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 0.89A 2bteA-3ziuA:
44.0		 2bteA-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 TYR A 361
TYR A  46
HIS A 371
HIS A 367
 None
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 1.21A 2bteA-3ziuA:
44.0		 2bteA-3ziuA:
32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		4 TYR A 489
TYR A 283
TYR A 296
HIS A 535
 None
 1.27A 2bteA-4aeeA:
undetectable		 2bteA-4aeeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		4 ASP A 153
SER A 182
TYR A 185
HIS A 142
 None
None
None
ZN  A 999 ( 3.2A)
 1.22A 2bteA-4aigA:
undetectable		 2bteA-4aigA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		4 ASP A 153
SER A 182
TYR A 185
HIS A 146
 None
None
None
ZN  A 999 ( 3.3A)
 1.28A 2bteA-4aigA:
undetectable		 2bteA-4aigA:
11.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		8 MET A  40
TYR A  43
ASP A  80
SER A 496
TYR A 499
TYR A 527
HIS A 533
HIS A 537
 LEU  A1001 ( 4.3A)
LEU  A1001 (-3.5A)
LEU  A1001 (-3.9A)
LEU  A1001 ( 3.7A)
None
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.67A 2bteA-4arcA:
34.7		 2bteA-4arcA:
45.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia porcellus) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 TYR A 571
SER A 319
TYR A 578
HIS A 616
 SO4  A1659 (-4.7A)
None
None
FAD  A 999 (-3.9A)
 1.37A 2bteA-4bc7A:
undetectable		 2bteA-4bc7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF02011
(Glyco_hydro_48) 		4 TYR A  59
ASP A 619
SER A 499
TYR A 506
 None
 1.24A 2bteA-4el8A:
undetectable		 2bteA-4el8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		4 TYR A 247
ASP A 218
SER A 214
TYR A 256
 None
 1.30A 2bteA-4j5tA:
3.2		 2bteA-4j5tA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kia LMO2213 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 TYR A 157
ASP A 155
TYR A  72
TYR A  53
 None
 1.12A 2bteA-4kiaA:
undetectable		 2bteA-4kiaA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		4 ASP A 230
SER A 272
TYR A 317
HIS A 308
 None
 1.31A 2bteA-4n0rA:
undetectable		 2bteA-4n0rA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A

(Ustilago maydis) 		PF03664
(Glyco_hydro_62) 		4 SER A  51
TYR A  58
TYR A 296
HIS A 261
 FUB  A 402 ( 4.4A)
FUB  A 402 ( 3.8A)
None
CA  A 401 (-3.6A)
 1.23A 2bteA-4n2rA:
undetectable		 2bteA-4n2rA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2z GH62
ARABINOFURANOSIDASE

(Podospora
anserina) 		PF03664
(Glyco_hydro_62) 		4 SER A  64
TYR A  71
TYR A 320
HIS A 285
 TRS  A 402 ( 4.4A)
TRS  A 402 (-4.6A)
CTR  A 405 ( 3.8A)
CA  A 401 ( 3.3A)
 1.21A 2bteA-4n2zA:
undetectable		 2bteA-4n2zA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvi GH62 HYDROLASE

(Mycothermus
thermophilus) 		PF03664
(Glyco_hydro_62) 		4 SER A  70
TYR A  77
TYR A 338
HIS A 303
 None
None
2WS  A 601 (-4.1A)
None
 1.18A 2bteA-4pviA:
undetectable		 2bteA-4pviA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxd 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE

(Entamoeba
histolytica) 		PF00459
(Inositol_P) 		4 TYR A 212
SER A 219
TYR A 248
HIS A 258
 None
 1.32A 2bteA-4qxdA:
undetectable		 2bteA-4qxdA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmd ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF05409
(Peptidase_C30) 		4 SER A 147
TYR A 164
HIS A 175
HIS A 166
 PGE  A 402 ( 3.9A)
None
None
PGE  A 402 (-4.6A)
 1.31A 2bteA-4wmdA:
undetectable		 2bteA-4wmdA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkq NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF00496
(SBP_bac_5) 		4 SER A 437
TYR A 438
TYR A 387
HIS A 242
 None
 1.33A 2bteA-4xkqA:
undetectable		 2bteA-4xkqA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwl EXOGLUCANASE S

(Clostridium
cellulovorans) 		PF02011
(Glyco_hydro_48) 		4 TYR A  54
ASP A 615
SER A 491
TYR A 498
 None
 1.27A 2bteA-4xwlA:
3.7		 2bteA-4xwlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzc NUCLEOPROTEIN

(Nairobi sheep
disease
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 SER A 310
TYR A 313
TYR A 110
HIS A 377
 None
 1.34A 2bteA-4xzcA:
2.4		 2bteA-4xzcA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xze NUCLEOPROTEIN

(Hazara
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 SER A 312
TYR A 315
TYR A 112
HIS A 379
 None
 1.29A 2bteA-4xzeA:
undetectable		 2bteA-4xzeA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ASP A  68
SER A  63
TYR A  96
HIS A 131
 None
 1.25A 2bteA-4zo6A:
undetectable		 2bteA-4zo6A:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		8 MET A  38
TYR A  41
ASP A  78
SER A 493
TYR A 496
TYR A 523
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.34A 2bteA-5ah5A:
46.5		 2bteA-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		4 TYR A 496
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 0.83A 2bteA-5ah5A:
46.5		 2bteA-5ah5A:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN

(Coprinopsis
cinerea) 		PF03664
(Glyco_hydro_62) 		4 SER A 124
TYR A 131
TYR A 380
HIS A 346
 GOL  A 502 ( 4.4A)
GOL  A 502 (-4.2A)
PB  A 500 ( 4.5A)
CA  A 501 (-3.3A)
 1.19A 2bteA-5b6tA:
undetectable		 2bteA-5b6tA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		4 TYR A 409
ASP A 401
SER A 353
HIS A 359
 None
 0.95A 2bteA-5bp8A:
4.0		 2bteA-5bp8A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd2 ENDO-1,4-D-GLUCANASE

(Aliivibrio
fischeri) 		PF01270
(Glyco_hydro_8) 		4 TYR A 203
ASP A 136
TYR A  79
TYR A 359
 None
GOL  A 402 (-2.9A)
None
None
 1.35A 2bteA-5cd2A:
undetectable		 2bteA-5cd2A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD

(Escherichia
coli) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 TYR A  50
ASP A  53
TYR A  23
HIS A 172
 None
 1.31A 2bteA-5fsrA:
undetectable		 2bteA-5fsrA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkv ESTERASE A

(Caulobacter
vibrioides) 		PF00144
(Beta-lactamase) 		4 MET A 311
TYR A 157
SER A  68
TYR A 319
 None
 1.29A 2bteA-5gkvA:
undetectable		 2bteA-5gkvA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy3 GLUCANASE

(Klebsiella
pneumoniae) 		PF01270
(Glyco_hydro_8) 		4 TYR A 175
ASP A 110
TYR A 316
HIS A  51
 None
 1.32A 2bteA-5gy3A:
2.6		 2bteA-5gy3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1t STAGE II SPORULATION
PROTEIN D

(Clostridioides
difficile) 		PF08486
(SpoIID) 		4 MET A 330
ASP A 224
SER A 323
HIS A 343
 None
 1.24A 2bteA-5i1tA:
undetectable		 2bteA-5i1tA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i33 ADENYLOSUCCINATE
SYNTHETASE

(Cryptococcus
neoformans) 		PF00709
(Adenylsucc_synt) 		4 TYR A 237
ASP A 234
SER A 249
TYR A 329
 None
 1.32A 2bteA-5i33A:
undetectable		 2bteA-5i33A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqk BETA-LACTAMASE RM3

(uncultured
bacterium) 		PF00753
(Lactamase_B) 		4 ASP A  77
SER A 107
TYR A 284
HIS A 254
 None
None
None
ZN  A 402 (-3.2A)
 1.23A 2bteA-5iqkA:
undetectable		 2bteA-5iqkA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 TYR A 299
TYR A 399
TYR A 374
HIS A 270
 None
None
None
FAD  A 901 (-4.8A)
 1.21A 2bteA-5l46A:
undetectable		 2bteA-5l46A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER

(Prochlorococcus
marinus) 		no annotation 4 TYR A 206
ASP A 205
SER A 128
TYR A 203
 GB  A 401 (-3.2A)
GB  A 401 (-2.7A)
GB  A 401 (-2.7A)
None
 1.26A 2bteA-5lq8A:
undetectable		 2bteA-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER

(Prochlorococcus
marinus) 		no annotation 4 TYR A 206
ASP A 205
TYR A 203
HIS A 158
 GB  A 401 (-3.2A)
GB  A 401 (-2.7A)
None
GB  A 401 (-4.0A)
 1.25A 2bteA-5lq8A:
undetectable		 2bteA-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		4 MET B  72
TYR B  80
TYR B  83
HIS B 304
 None
None
K  B 605 ( 3.2A)
None
 1.09A 2bteA-5m99B:
undetectable		 2bteA-5m99B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C)
PF04616
(Glyco_hydro_43) 		4 ASP A 413
SER A 411
TYR A 442
TYR A 330
 None
 1.20A 2bteA-5msxA:
undetectable		 2bteA-5msxA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odb D10 FAB FRAGMENT -
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 TYR A 107
ASP A  33
SER A  52
TYR A  53
 None
 1.30A 2bteA-5odbA:
undetectable		 2bteA-5odbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 4 ASP A 636
SER A 634
TYR A 188
HIS A 546
 None
 1.19A 2bteA-5opqA:
undetectable		 2bteA-5opqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 4 MET A  23
ASP A  19
TYR A  27
HIS A 589
 None
 1.25A 2bteA-5oynA:
undetectable		 2bteA-5oynA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8d BACILLUS CEREUS
PATB1

(Bacillus cereus) 		no annotation 4 ASP C 336
SER C 383
TYR C 196
HIS C 201
 SO4  C 403 (-3.9A)
None
None
SO4  C 403 (-3.8A)
 1.28A 2bteA-5v8dC:
undetectable		 2bteA-5v8dC:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum) 		no annotation 4 TYR A  38
ASP A  35
TYR A 170
TYR A 146
 TYR  A  38 ( 1.3A)
ASP  A  35 ( 0.6A)
TYR  A 170 ( 1.3A)
TYR  A 146 ( 1.3A)
 1.37A 2bteA-5w0aA:
undetectable		 2bteA-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x18 CASEIN KINASE I
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 MET A 258
ASP A 256
TYR A 331
HIS A 180
 None
 1.16A 2bteA-5x18A:
undetectable		 2bteA-5x18A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqj BETA-XYLOSIDASE

(Bacillus
pumilus) 		no annotation 4 ASP A 477
SER A 475
TYR A 460
TYR A 527
 None
 1.34A 2bteA-5zqjA:
undetectable		 2bteA-5zqjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 4 TYR A 110
ASP A 312
SER A 308
TYR A  73
 None
 1.09A 2bteA-6c6lA:
undetectable		 2bteA-6c6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e0s -

(-) 		no annotation 4 ASP A  60
SER A  90
TYR A 267
HIS A 237
 None
None
None
ZN  A 302 (-4.3A)
 1.30A 2bteA-6e0sA:
undetectable		 2bteA-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoq DIPEPTIDYL PEPTIDASE
9

(Homo sapiens) 		no annotation 4 TYR A 762
ASP A 763
HIS A 815
HIS A 812
 None
 1.35A 2bteA-6eoqA:
undetectable		 2bteA-6eoqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f79 -

(-) 		no annotation 4 ASP A 260
TYR A 149
HIS A  69
HIS A  68
 0X9  A 407 (-4.3A)
None
ZN  A 401 ( 3.1A)
None
 1.25A 2bteA-6f79A:
undetectable		 2bteA-6f79A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g21 PROBABLE FERULOYL
ESTERASE B-2

(Aspergillus
oryzae) 		no annotation 4 TYR A 327
ASP A 323
SER A 122
HIS A 118
 None
 1.34A 2bteA-6g21A:
undetectable		 2bteA-6g21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 4 TYR A 600
ASP A 405
SER A 407
TYR A 544
 None
 1.34A 2bteA-6gh2A:
undetectable		 2bteA-6gh2A:
undetectable