SIMILAR PATTERNS OF AMINO ACIDS FOR 2BR4_F_SAMF301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crk CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 LYS A 380
ASP A 107
CYH A 249
 None
 1.25A 2br4F-1crkA:
undetectable		 2br4F-1crkA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyn CHLOROPLASTIC
ASCORBATE PEROXIDASE

(Nicotiana
tabacum) 		PF00141
(peroxidase) 		3 LYS A  78
ASP A  35
CYH A 124
 None
NA  A 298 (-3.1A)
None
 1.49A 2br4F-1iynA:
undetectable		 2br4F-1iynA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2x CLASS B
CARBAPENEMASE BLAB-1

(Elizabethkingia
meningoseptica) 		PF00753
(Lactamase_B) 		3 LYS A 167
ASP A  84
CYH A 221
 MCO  A 811 ( 2.7A)
None
ZN  A 902 (-2.3A)
 1.11A 2br4F-1m2xA:
undetectable		 2br4F-1m2xA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP) 		3 LYS A 287
ASP A 274
CYH A 218
 None
 1.29A 2br4F-1o7fA:
undetectable		 2br4F-1o7fA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 LYS A 336
ASP A 356
CYH A 349
 None
 1.38A 2br4F-1qlbA:
undetectable		 2br4F-1qlbA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3

(Bos taurus) 		PF00022
(Actin) 		3 LYS A 225
ASP A  64
CYH A  34
 ADP  A1001 (-3.4A)
None
None
 1.48A 2br4F-1u2vA:
undetectable		 2br4F-1u2vA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w07 ACYL-COA OXIDASE

(Arabidopsis
thaliana) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 LYS A 228
ASP A 100
CYH A  69
 None
 0.86A 2br4F-1w07A:
undetectable		 2br4F-1w07A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjd T-CELL-SPECIFIC
SURFACE GLYCOPROTEIN
CD28
FAB FRAGMENT OF
5.11A1 ANTIBODY
HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		PF15910
(V-set_2)
PF07654
(C1-set)
PF07686
(V-set) 		3 LYS C  95
ASP H 104
CYH H  50
 None
 1.33A 2br4F-1yjdC:
undetectable		 2br4F-1yjdC:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  38
ASP A 130
CYH A 168
 HYM  A 400 (-3.2A)
None
None
 1.50A 2br4F-1zltA:
undetectable		 2br4F-1zltA:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		3 LYS A  65
ASP A 116
CYH A 139
 SAM  A 301 (-2.6A)
SAM  A 301 (-3.0A)
SAM  A 301 (-2.9A)
 0.33A 2br4F-2br4A:
34.9		 2br4F-2br4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chr CHLOROMUCONATE
CYCLOISOMERASE

(Cupriavidus
necator) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS A 163
ASP A 300
CYH A 271
 CL  A 500 ( 3.8A)
None
None
 1.34A 2br4F-2chrA:
undetectable		 2br4F-2chrA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 LYS A 371
ASP A 466
CYH A 502
 PDS  A 901 ( 4.5A)
None
TPO  A 500 ( 3.9A)
 1.46A 2br4F-2i0eA:
undetectable		 2br4F-2i0eA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS X 100
ASP X 241
CYH X 244
 None
 1.27A 2br4F-2p3gX:
undetectable		 2br4F-2p3gX:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG

(Escherichia
coli) 		PF13483
(Lactamase_B_3) 		3 LYS A  90
ASP A 226
CYH A  45
 None
MN  A1341 (-3.6A)
MN  A1341 ( 4.9A)
 0.91A 2br4F-2wymA:
undetectable		 2br4F-2wymA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N
LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Thermosynechococcus
elongatus;
Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro)
PF00148
(Oxidored_nitro) 		3 LYS B  72
ASP B  36
CYH A 107
 None
SF4  A 602 (-2.8A)
SF4  A 602 (-2.3A)
 1.32A 2br4F-2xdqB:
3.4		 2br4F-2xdqB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA

(Methanocaldococcus
jannaschii) 		PF00282
(Pyridoxal_deC) 		3 LYS A 137
ASP A 242
CYH A  38
 None
PLP  A 500 (-4.2A)
None
 1.15A 2br4F-3f9tA:
2.4		 2br4F-3f9tA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbx GLUTAMATE
DECARBOXYLASE 1

(Arabidopsis
thaliana) 		PF00282
(Pyridoxal_deC) 		3 LYS A 278
ASP A 244
CYH A 166
 LLP  A 277 ( 3.2A)
LLP  A 277 ( 2.8A)
LLP  A 277 ( 4.0A)
 1.21A 2br4F-3hbxA:
2.6		 2br4F-3hbxA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6n METALLO-BETA-LACTAMA
SE

(Chryseobacterium
indologenes) 		PF00753
(Lactamase_B) 		3 LYS A 130
ASP A  66
CYH A 178
 None
None
ZN  A 302 (-2.0A)
 1.14A 2br4F-3l6nA:
undetectable		 2br4F-3l6nA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1
RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
2

(Homo sapiens;
Homo sapiens) 		PF16099
(RMI1_C)
PF16100
(RMI2) 		3 LYS A 511
ASP A 587
CYH B  95
 None
 1.32A 2br4F-3nbhA:
undetectable		 2br4F-3nbhA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndn O-SUCCINYLHOMOSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF01053
(Cys_Met_Meta_PP) 		3 LYS A 220
ASP A 194
CYH A 125
 LLP  A 219 ( 2.9A)
LLP  A 219 ( 3.1A)
LLP  A 219 ( 4.1A)
 1.40A 2br4F-3ndnA:
3.5		 2br4F-3ndnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovg AMIDOHYDROLASE

(Mycoplasma
synoviae) 		PF02126
(PTE) 		3 LYS A  29
ASP A  22
CYH A 236
 ZN  A 362 ( 4.9A)
None
None
 1.27A 2br4F-3ovgA:
undetectable		 2br4F-3ovgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 LYS A 483
ASP A 228
CYH A 187
 None
 1.38A 2br4F-3p5pA:
undetectable		 2br4F-3p5pA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8y 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00132
(Hexapep)
PF08503
(DapH_N)
PF14602
(Hexapep_2) 		3 LYS A 164
ASP A 170
CYH A 146
 None
 1.30A 2br4F-3r8yA:
undetectable		 2br4F-3r8yA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		3 LYS A 415
ASP A  83
CYH A 427
 None
 1.15A 2br4F-3szbA:
3.6		 2br4F-3szbA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		3 LYS A 352
ASP A 556
CYH A 364
 ACP  A1001 ( 4.3A)
None
None
 1.12A 2br4F-3tlmA:
2.8		 2br4F-3tlmA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0i VOLTAGE-SENSOR
CONTAINING
PHOSPHATASE

(Ciona
intestinalis) 		PF00782
(DSPc)
PF10409
(PTEN_C2) 		3 LYS A 553
ASP A 331
CYH A 363
 None
None
SO4  A 601 ( 4.4A)
 1.25A 2br4F-3v0iA:
undetectable		 2br4F-3v0iA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		3 LYS A  45
ASP A 139
CYH A 174
 STU  A1550 (-3.6A)
None
TPO  A 172 ( 3.7A)
 1.43A 2br4F-4cfhA:
undetectable		 2br4F-4cfhA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
BMAL1B

(Mus musculus;
Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11)
PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11) 		3 LYS B 398
ASP A 317
CYH A 337
 None
 0.97A 2br4F-4f3lB:
undetectable		 2br4F-4f3lB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		3 LYS B1918
ASP B1734
CYH B1731
 None
 1.12A 2br4F-4f92B:
undetectable		 2br4F-4f92B:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		3 LYS A 274
ASP A 213
CYH A 171
 None
 1.26A 2br4F-4i2wA:
undetectable		 2br4F-4i2wA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-RELATED
PROTEIN 7
ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00022
(Actin)
PF00022
(Actin) 		3 LYS A 433
ASP B 318
CYH B 403
 None
PO4  B 506 (-3.1A)
None
 1.48A 2br4F-4i6mA:
undetectable		 2br4F-4i6mA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it1 PUTATIVE GLUCARATE
DEHYDRATASE

(Pseudomonas
fluorescens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS A 191
ASP A 343
CYH A 310
 None
 1.47A 2br4F-4it1A:
undetectable		 2br4F-4it1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll6 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		3 LYS A1272
ASP A1315
CYH A1320
 None
 1.39A 2br4F-4ll6A:
undetectable		 2br4F-4ll6A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh7 ORNITHINE
CARBAMOYLTRANSFERASE

(Brucella
melitensis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 LYS A  29
ASP A 142
CYH A 222
 None
 1.19A 2br4F-4oh7A:
3.8		 2br4F-4oh7A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A1037
ASP A 988
CYH A1098
 None
 1.14A 2br4F-4oliA:
undetectable		 2br4F-4oliA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		3 LYS A 123
ASP A 391
CYH A 385
 None
None
ZN  A 804 (-2.4A)
 1.47A 2br4F-4qeoA:
undetectable		 2br4F-4qeoA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		3 LYS A  47
ASP A 141
CYH A 176
 STU  A 601 ( 3.7A)
None
None
 1.27A 2br4F-4rewA:
undetectable		 2br4F-4rewA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9p UPF0264 PROTEIN
MJ1099

(Methanocaldococcus
jannaschii) 		PF04476
(4HFCP_synth) 		3 LYS A  85
ASP A  22
CYH A 234
 None
 1.31A 2br4F-4u9pA:
undetectable		 2br4F-4u9pA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubq BETA-LACTAMASE

(Acinetobacter
baumannii) 		no annotation 3 LYS A 112
ASP A  49
CYH A 159
 None
None
ZN  A 302 (-1.8A)
 1.04A 2br4F-4ubqA:
undetectable		 2br4F-4ubqA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyk NUCLEAR RNA EXPORT
FACTOR 1

(Homo sapiens) 		PF02136
(NTF2) 		3 LYS A 230
ASP A 352
CYH A 328
 None
 1.44A 2br4F-4wykA:
undetectable		 2br4F-4wykA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcs CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Plasmodium
falciparum) 		PF01467
(CTP_transf_like) 		3 LYS A 719
ASP A 623
CYH A 690
 None
CDC  A 801 (-3.5A)
CDC  A 801 ( 4.9A)
 1.48A 2br4F-4zcsA:
undetectable		 2br4F-4zcsA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Homo sapiens;
Mus musculus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		3 LYS A2164
ASP A2072
CYH A 316
 None
 1.07A 2br4F-4zwjA:
undetectable		 2br4F-4zwjA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		3 LYS A1474
ASP A 913
CYH A 843
 None
 1.31A 2br4F-5amqA:
undetectable		 2br4F-5amqA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		3 LYS A1309
ASP A 993
CYH A 981
 None
 1.36A 2br4F-5dotA:
4.8		 2br4F-5dotA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7o METHYLTHIOADENOSINE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		3 LYS A 197
ASP A 100
CYH A 168
 None
 1.34A 2br4F-5f7oA:
undetectable		 2br4F-5f7oA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7o METHYLTHIOADENOSINE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		3 LYS A 235
ASP A 100
CYH A 168
 None
 1.21A 2br4F-5f7oA:
undetectable		 2br4F-5f7oA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 LYS A 835
ASP A 711
CYH A 459
 None
 1.07A 2br4F-5i2gA:
undetectable		 2br4F-5i2gA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 LYS A 226
ASP A 605
CYH A 572
 FAD  A 702 (-3.5A)
None
None
 1.10A 2br4F-5i68A:
undetectable		 2br4F-5i68A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmd METALLO-BETA-LACTAMA
SE 1

(Acinetobacter
baumannii) 		PF00753
(Lactamase_B) 		3 LYS E 165
ASP E  84
CYH E 221
 None
None
ZN  E 401 (-2.3A)
 1.13A 2br4F-5mmdE:
undetectable		 2br4F-5mmdE:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9w THEBAINE
6-O-DEMETHYLASE

(Papaver
somniferum) 		no annotation 3 LYS A 259
ASP A 280
CYH A 348
 None
 1.44A 2br4F-5o9wA:
undetectable		 2br4F-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1a FERRITIN,MTRE
PROTEIN CHIMERA

(Helicobacter
pylori;
Neisseria
gonorrhoeae) 		no annotation 3 LYS A 181
ASP A 170
CYH A  31
 None
 1.50A 2br4F-5u1aA:
undetectable		 2br4F-5u1aA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2j HISTONE
ACETYLTRANSFERASE
KAT6B

(Homo sapiens) 		PF00628
(PHD) 		3 LYS A 263
ASP A 282
CYH A 245
 None
 1.17A 2br4F-5u2jA:
undetectable		 2br4F-5u2jA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s DNA REPLICATION
LICENSING FACTOR
MCM4

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 LYS 4 302
ASP 4 462
CYH 4 418
 None
 1.43A 2br4F-5u8s4:
undetectable		 2br4F-5u8s4:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbn DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Homo sapiens) 		no annotation 3 LYS B2209
ASP B2166
CYH B2164
 None
 1.49A 2br4F-5vbnB:
undetectable		 2br4F-5vbnB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0m TERMINAL
URIDYLYLTRANSFERASE
7

(Homo sapiens) 		PF00098
(zf-CCHC)
PF03828
(PAP_assoc) 		3 LYS A1274
ASP A1344
CYH A1346
 U  H   1 ( 4.3A)
None
None
 1.37A 2br4F-5w0mA:
undetectable		 2br4F-5w0mA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 3 LYS A 685
ASP A 703
CYH A 708
 None
 1.44A 2br4F-6eotA:
undetectable		 2br4F-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus;
Influenza B
virus) 		no annotation
no annotation 		3 LYS B 207
ASP C  15
CYH B 691
 None
 1.32A 2br4F-6f5oB:
undetectable		 2br4F-6f5oB:
undetectable