SIMILAR PATTERNS OF AMINO ACIDS FOR 2BR4_E_SAME301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azz COLLAGENASE

(Leptuca
pugilator) 		PF00089
(Trypsin) 		5 LEU A 155
GLU A  77
GLY A  69
ALA A 117
ALA A 116
 None
 1.13A 2br4E-1azzA:
undetectable		 2br4E-1azzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  24
GLY A  85
ARG A 355
ARG A  31
ALA A  84
 None
 1.18A 2br4E-1bucA:
undetectable		 2br4E-1bucA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct9 ASPARAGINE
SYNTHETASE B

(Escherichia
coli) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 LEU A 215
LEU A 432
LYS A 429
GLY A 347
ASP A 238
 None
None
IUM  A1101 ( 3.9A)
AMP  A1100 (-3.7A)
IUM  A1101 ( 3.0A)
 1.16A 2br4E-1ct9A:
undetectable		 2br4E-1ct9A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I

(Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 LEU A 208
LEU A 197
GLY A  77
ARG A 207
ALA A  58
 None
 1.11A 2br4E-1i1qA:
undetectable		 2br4E-1i1qA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		5 LEU A 511
LEU A 458
GLY A 538
ALA A 467
ALA A 471
 None
 0.93A 2br4E-1itkA:
undetectable		 2br4E-1itkA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1i META CLEAVAGE
COMPOUND HYDROLASE

(Janthinobacterium) 		PF12697
(Abhydrolase_6) 		5 GLY A  34
TYR A  66
ARG A  64
ALA A  33
ALA A  15
 None
 1.15A 2br4E-1j1iA:
2.3		 2br4E-1j1iA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB

(Thermotoga
maritima) 		PF06723
(MreB_Mbl) 		5 LEU A 128
GLY A 118
ASP A 116
ALA A 117
ALA A  76
 None
 1.18A 2br4E-1jcfA:
undetectable		 2br4E-1jcfA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oaa SEPIAPTERIN
REDUCTASE

(Mus musculus) 		PF00106
(adh_short) 		5 LEU A 127
GLY A  76
ASP A  70
ALA A  69
ALA A  67
 NAP  A 800 (-4.2A)
SO4  A 802 (-3.4A)
NAP  A 800 ( 2.8A)
SO4  A 802 ( 4.1A)
None
 1.18A 2br4E-1oaaA:
5.9		 2br4E-1oaaA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc3 PHOSPHATE-BINDING
PROTEIN 1

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		5 LEU A 309
LEU A  30
GLY A  80
ALA A  72
ALA A  73
 None
 1.02A 2br4E-1pc3A:
undetectable		 2br4E-1pc3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR

(Homo sapiens) 		PF02089
(Palm_thioest) 		5 LEU A 115
LEU A  83
TYR A 178
ASP A 185
ALA A 196
 None
 1.16A 2br4E-1pjaA:
3.2		 2br4E-1pjaA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		6 LEU A  29
LYS A  27
GLU A 422
GLY A 421
ALA A  20
ALA A  16
 None
None
None
None
None
FAD  A1656 (-3.4A)
 1.43A 2br4E-1qlbA:
undetectable		 2br4E-1qlbA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		5 LEU A 513
LEU A 462
GLY A 533
ALA A 471
ALA A 475
 None
 1.00A 2br4E-1u2lA:
undetectable		 2br4E-1u2lA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		5 LEU A 102
LEU A 108
GLY A  45
ASP A  63
ALA A 172
 None
 1.17A 2br4E-1upxA:
undetectable		 2br4E-1upxA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 LEU A 342
LEU A 340
GLY A 387
TYR A 329
ALA A  87
 None
 1.17A 2br4E-1xc6A:
undetectable		 2br4E-1xc6A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		5 GLY A  13
ARG A  38
ARG A  42
ASP A  66
ALA A  94
 NDP  A1281 (-2.9A)
NDP  A1281 (-3.8A)
NDP  A1281 (-2.7A)
NDP  A1281 (-3.6A)
NDP  A1281 (-3.7A)
 0.92A 2br4E-1xkqA:
5.4		 2br4E-1xkqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 276
GLU A  34
GLY A  11
ALA A 145
ALA A 307
 None
FAD  A 666 (-2.5A)
FAD  A 666 (-3.2A)
FAD  A 666 (-4.9A)
None
 1.01A 2br4E-1zk7A:
3.4		 2br4E-1zk7A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8e CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 LEU A 429
GLY A 617
ASP A 647
ASP A 424
ALA A 629
 None
 1.07A 2br4E-2b8eA:
2.6		 2br4E-2b8eA:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		12 LEU A  18
LEU A  64
LYS A  65
GLU A  87
GLY A  89
TYR A  91
ARG A 117
ARG A 121
ASP A 138
ASP A 160
ALA A 161
ALA A 163
 SAM  A 301 ( 4.4A)
SAM  A 301 (-4.2A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.7A)
MG  A 300 ( 3.6A)
SAM  A 301 (-3.6A)
SAM  A 301 ( 3.7A)
 0.30A 2br4E-2br4A:
35.2		 2br4E-2br4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  22
GLY A  83
TYR A  81
ALA A  86
ALA A  90
 None
 0.95A 2br4E-2cx9A:
undetectable		 2br4E-2cx9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfu PROBABLE
2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE

(Thermus
thermophilus) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		5 LEU A 236
GLU A 116
TYR A 113
ASP A 145
ALA A  87
 None
 1.09A 2br4E-2dfuA:
undetectable		 2br4E-2dfuA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h26 T-CELL SURFACE
GLYCOPROTEIN CD1B

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		5 LEU A 259
GLY A 254
ARG A 222
ASP A 253
ALA A 252
 None
 1.12A 2br4E-2h26A:
undetectable		 2br4E-2h26A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoq PUTATIVE
HAD-HYDROLASE PH1655

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		5 LEU A  65
LEU A  36
GLY A  81
ALA A  27
ALA A  23
 None
 1.11A 2br4E-2hoqA:
3.0		 2br4E-2hoqA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsz NOVEL PREDICTED
PHOSPHATASE

(Histophilus
somni) 		PF13419
(HAD_2) 		5 LEU A  15
GLY A 175
ASP A 210
ASP A  10
ALA A 184
 None
 1.16A 2br4E-2hszA:
3.0		 2br4E-2hszA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jww PARVALBUMIN ALPHA

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		5 LEU A  77
GLU A 101
GLY A  89
ASP A  90
ALA A  88
 None
 0.94A 2br4E-2jwwA:
undetectable		 2br4E-2jwwA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila) 		PF13378
(MR_MLE_C) 		5 LEU A  81
LEU A  85
GLY A  44
ALA A 128
ALA A 124
 None
 1.03A 2br4E-2pgeA:
undetectable		 2br4E-2pgeA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		5 LEU A 107
GLY A 104
ASP A  60
ALA A 111
ALA A  99
 None
FAD  A1535 (-3.3A)
None
FAD  A1535 ( 3.7A)
FAD  A1535 ( 4.3A)
 1.07A 2br4E-2qpmA:
undetectable		 2br4E-2qpmA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rek PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 LEU A  74
LEU A 132
GLY A 102
ARG A  70
ALA A  99
 None
 1.00A 2br4E-2rekA:
undetectable		 2br4E-2rekA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rli SCO2 PROTEIN
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF02630
(SCO1-SenC) 		5 LEU A 125
LEU A 144
LYS A 143
GLY A 242
ALA A 227
 None
 1.14A 2br4E-2rliA:
undetectable		 2br4E-2rliA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		5 LEU A 174
LEU A  90
GLY A  83
ALA A 113
ALA A 117
 None
None
SFD  A1418 ( 4.3A)
SFD  A1418 (-3.5A)
SFD  A1418 (-3.2A)
 0.87A 2br4E-2vfvA:
undetectable		 2br4E-2vfvA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 LEU I 429
GLY I 617
ASP I 647
ASP I 424
ALA I 629
 None
 1.07A 2br4E-2voyI:
2.6		 2br4E-2voyI:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE

(Pseudomonas
fluorescens) 		PF00378
(ECH_1) 		5 LEU C  45
LEU C  57
TYR C 105
ALA C 127
ALA C 123
 None
 1.17A 2br4E-2vsuC:
undetectable		 2br4E-2vsuC:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrm INTRACELLULAR
SUBTILISIN PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		5 LEU A 154
LEU A 118
GLY A 127
ALA A 130
ALA A 166
 None
 1.15A 2br4E-2xrmA:
undetectable		 2br4E-2xrmA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg8 DNA-3-METHYLADENINE
GLYCOSIDASE II,
PUTATIVE

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		5 LEU A  86
LEU A 111
GLY A  71
ARG A  67
ALA A  79
 None
 0.98A 2br4E-2yg8A:
undetectable		 2br4E-2yg8A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		5 GLY A 425
ARG A  73
ASP A 427
ALA A 428
ALA A 432
 None
 1.14A 2br4E-2ykyA:
2.6		 2br4E-2ykyA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 LEU A 389
GLY A  63
TYR A  93
ALA A 409
ALA A 650
 None
FAD  A 801 (-3.1A)
None
None
None
 0.85A 2br4E-2yr5A:
undetectable		 2br4E-2yr5A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350

(Thermus
thermophilus) 		PF00582
(Usp) 		5 LEU A 228
LEU A 238
GLY A 241
ALA A 167
ALA A 163
 LEU  A 228 ( 0.6A)
LEU  A 238 ( 0.6A)
GLY  A 241 ( 0.0A)
ALA  A 167 ( 0.0A)
ALA  A 163 ( 0.0A)
 1.09A 2br4E-3ab7A:
2.2		 2br4E-3ab7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfm BIOTIN PROTEIN
LIGASE-LIKE PROTEIN
OF UNKNOWN FUNCTION

(Ruegeria sp.
TM1040) 		PF14563
(DUF4444)
PF16917
(BPL_LplA_LipB_2) 		5 LEU A 159
LEU A  48
GLY A 125
ALA A  51
ALA A  26
 None
 1.14A 2br4E-3bfmA:
undetectable		 2br4E-3bfmA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjm PUTATIVE
BETA-LACTAMASE

(Enterococcus
faecalis) 		PF13354
(Beta-lactamase2) 		5 LYS A 198
GLU A 103
ASP A 267
ASP A 211
ALA A 212
 None
 0.99A 2br4E-3cjmA:
undetectable		 2br4E-3cjmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		5 LEU A 183
LEU A 122
GLY A 115
ASP A 140
ALA A 148
 None
 1.16A 2br4E-3cwcA:
undetectable		 2br4E-3cwcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE

(Brucella
abortus) 		PF00171
(Aldedh) 		5 LEU A 310
GLY A 277
ASP A 276
ALA A 274
ALA A 269
 None
 1.14A 2br4E-3ek1A:
3.4		 2br4E-3ek1A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs2 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Brucella
melitensis) 		PF00793
(DAHP_synth_1) 		5 LEU A 264
LEU A  50
GLY A  53
ALA A  22
ALA A 234
 None
 1.16A 2br4E-3fs2A:
undetectable		 2br4E-3fs2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3e UNCHARACTERIZED
PROTEIN TM1679

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		5 LEU A  69
LEU A  39
GLU A  18
GLY A  33
ALA A  93
 None
 1.16A 2br4E-3h3eA:
undetectable		 2br4E-3h3eA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7t GROUP 3 ALLERGEN
SMIPP-S YVT004A06

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		5 LYS A   1
GLY A 184
ASP A 185
ALA A 186
ALA A  39
 None
 0.87A 2br4E-3h7tA:
undetectable		 2br4E-3h7tA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ha2 NADPH-QUINONE
REDUCTASE

(Pediococcus
pentosaceus) 		PF02525
(Flavodoxin_2) 		5 LEU A  61
GLY A 105
ASP A 103
ALA A 107
ALA A 112
 None
 1.16A 2br4E-3ha2A:
undetectable		 2br4E-3ha2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase) 		5 LEU A 429
GLY A 617
ASP A 647
ASP A 424
ALA A 629
 None
 1.13A 2br4E-3j09A:
2.5		 2br4E-3j09A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 LEU E 213
LEU E  98
LYS E  99
ALA E  64
ALA E 148
 None
 1.14A 2br4E-3kfuE:
undetectable		 2br4E-3kfuE:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky9 PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF)
PF11971
(CAMSAP_CH) 		5 LEU A 334
LYS A 335
GLY A 170
ASP A 171
ALA A 168
 None
 1.14A 2br4E-3ky9A:
undetectable		 2br4E-3ky9A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		5 LEU A 335
LEU A 339
GLY A 321
ALA A 294
ALA A 273
 None
 0.96A 2br4E-3lscA:
undetectable		 2br4E-3lscA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m33 UNCHARACTERIZED
PROTEIN

(Deinococcus
radiodurans) 		no annotation 5 LEU A  43
LEU A  39
ASP A  91
ASP A  59
ALA A  60
 None
None
None
GOL  A 233 (-3.3A)
None
 1.17A 2br4E-3m33A:
8.8		 2br4E-3m33A:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3maj DNA PROCESSING CHAIN
A

(Rhodopseudomonas
palustris) 		PF02481
(DNA_processg_A) 		5 LEU A 198
LEU A 162
GLY A 165
ASP A 167
ALA A 169
 None
 1.15A 2br4E-3majA:
undetectable		 2br4E-3majA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		5 LEU A 321
LEU A  60
TYR A 208
ASP A 200
ALA A 197
 None
 1.08A 2br4E-3mzvA:
undetectable		 2br4E-3mzvA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmo UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00132
(Hexapep)
PF04613
(LpxD) 		5 LEU A  92
GLY A  10
TYR A   7
ALA A  13
ALA A  18
 None
 1.08A 2br4E-3pmoA:
undetectable		 2br4E-3pmoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 LEU A 160
LEU A 164
GLY A 134
ALA A  83
ALA A  85
 None
 1.10A 2br4E-3pwzA:
4.9		 2br4E-3pwzA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3v PHOSPHOGLYCERATE
KINASE

(Campylobacter
jejuni) 		PF00162
(PGK) 		5 LEU A  12
GLY A 172
TYR A  48
ASP A 180
ALA A 171
 None
 1.14A 2br4E-3q3vA:
undetectable		 2br4E-3q3vA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r20 CYTIDYLATE KINASE

(Mycolicibacterium
smegmatis) 		PF02224
(Cytidylate_kin) 		5 LEU A 218
GLY A  30
ARG A  27
ASP A  76
ALA A  26
 None
 1.13A 2br4E-3r20A:
undetectable		 2br4E-3r20A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssm METHYLTRANSFERASE

(Micromonospora
griseorubida) 		no annotation 5 LYS A 175
GLU A 202
GLY A 204
ASP A 252
ASP A 275
 SAH  A 601 (-3.1A)
SAH  A 601 (-3.4A)
SAH  A 601 (-3.5A)
SAH  A 601 (-3.6A)
MG  A 501 ( 2.8A)
 1.04A 2br4E-3ssmA:
12.1		 2br4E-3ssmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA

(Streptococcus
pneumoniae) 		PF02481
(DNA_processg_A) 		5 LEU A 180
LEU A 142
GLY A 145
ASP A 147
ALA A 149
 None
 1.13A 2br4E-3uqzA:
undetectable		 2br4E-3uqzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		5 LEU A 564
LEU A 511
GLY A 590
ALA A 520
ALA A 524
 None
 0.99A 2br4E-3ut2A:
undetectable		 2br4E-3ut2A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		5 LEU A 510
LEU A 457
GLY A 529
ALA A 466
ALA A 470
 None
 1.06A 2br4E-3wxoA:
undetectable		 2br4E-3wxoA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az7 BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		5 GLY A 227
TYR A 261
ASP A 299
ALA A 300
ALA A 304
 None
 0.99A 2br4E-4az7A:
undetectable		 2br4E-4az7A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azc BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		5 GLY A 672
TYR A 706
ASP A 744
ALA A 745
ALA A 749
 None
 0.96A 2br4E-4azcA:
undetectable		 2br4E-4azcA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvl PHB DEPOLYMERASE
PHAZ7

(Paucimonas
lemoignei) 		PF01674
(Lipase_2) 		5 LYS A   1
GLY A  34
TYR A  18
ASP A  84
ALA A  38
 None
 1.15A 2br4E-4bvlA:
2.8		 2br4E-4bvlA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		5 LEU A 230
LEU A 110
GLY A  69
TYR A  67
ALA A 181
 None
 1.03A 2br4E-4c1oA:
undetectable		 2br4E-4c1oA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 LEU A 521
LEU A 467
GLY A 548
ALA A 476
ALA A 480
 None
 0.91A 2br4E-4c51A:
undetectable		 2br4E-4c51A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 GLU A 174
GLY A 202
ASP A 203
ALA A 206
ALA A 209
 None
 1.03A 2br4E-4e4gA:
3.7		 2br4E-4e4gA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 LEU A 283
LEU A 205
GLY A 164
ASP A 163
ALA A 161
 None
 1.14A 2br4E-4efcA:
undetectable		 2br4E-4efcA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqg TRANSCRIPTION
ELONGATION REGULATOR
1

(Homo sapiens) 		PF01846
(FF) 		5 LEU A  54
LEU A  16
GLY A  43
ARG A   5
ALA A   8
 None
 1.15A 2br4E-4fqgA:
undetectable		 2br4E-4fqgA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 LYS H 445
GLY H 631
ASP H 632
ALA H 633
ALA H 481
 None
 0.89A 2br4E-4fxgH:
undetectable		 2br4E-4fxgH:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE

(Escherichia
coli) 		PF00378
(ECH_1) 		6 LEU A  31
LEU A 110
GLY A  62
ARG A  81
ALA A  25
ALA A  22
 None
None
None
GOL  A 301 (-3.5A)
None
None
 1.46A 2br4E-4fzwA:
undetectable		 2br4E-4fzwA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0p ACETATE KINASE

(Cryptococcus
neoformans) 		PF00871
(Acetate_kinase) 		5 LEU A  83
GLY A  20
ASP A 415
ALA A  10
ALA A 421
 None
 1.16A 2br4E-4h0pA:
undetectable		 2br4E-4h0pA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		5 GLU A 279
GLY A 275
TYR A 125
ARG A 124
ALA A 218
 None
 0.95A 2br4E-4hpvA:
undetectable		 2br4E-4hpvA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2u ENOYL-COA HYDRATASE

(Rhodobacter
sphaeroides) 		PF16113
(ECH_2) 		5 LEU A 162
GLY A 170
ASP A 173
ALA A 174
ALA A 180
 None
 1.05A 2br4E-4j2uA:
undetectable		 2br4E-4j2uA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxn OCTAPRENYL-DIPHOSPHA
TE SYNTHASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 LEU A 321
LEU A  60
TYR A 208
ASP A 200
ALA A 197
 None
 1.06A 2br4E-4jxnA:
undetectable		 2br4E-4jxnA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		5 LEU A 315
LEU A 337
GLY A 343
ALA A  77
ALA A  81
 None
 1.15A 2br4E-4kv7A:
4.7		 2br4E-4kv7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4i RYANODINE RECEPTOR 2

(Mus musculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		5 LEU A 436
LEU A 447
GLY A 519
ALA A 515
ALA A 512
 None
 1.14A 2br4E-4l4iA:
undetectable		 2br4E-4l4iA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4x AMPHI

(Streptomyces
nodosus) 		PF08659
(KR) 		5 GLY A 284
ARG A 310
ARG A 311
ALA A 366
ALA A 388
 NDP  A 601 (-3.3A)
NDP  A 601 (-3.1A)
NDP  A 601 (-3.9A)
NDP  A 601 (-4.1A)
NDP  A 601 ( 3.9A)
 1.09A 2br4E-4l4xA:
2.4		 2br4E-4l4xA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3

(Brucella
melitensis) 		PF13458
(Peripla_BP_6) 		5 LEU A 111
LEU A  98
GLY A  80
ASP A  73
ALA A  83
 None
 1.16A 2br4E-4n0qA:
2.7		 2br4E-4n0qA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 LEU A  98
LEU A 148
GLY A 138
ALA A 136
ALA A  29
 None
 1.18A 2br4E-4nbqA:
undetectable		 2br4E-4nbqA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnz PROBABLE ZINC
PROTEASE

(Pseudomonas
aeruginosa) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 GLY A 272
TYR A 300
ARG A 269
ASP A 276
ALA A 273
 None
 1.14A 2br4E-4nnzA:
undetectable		 2br4E-4nnzA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Bacillus
anthracis) 		PF00588
(SpoU_methylase) 		5 LEU A   7
LEU A 136
GLY A  17
ALA A  20
ALA A  24
 None
SAH  A 201 ( 4.3A)
None
None
None
 1.18A 2br4E-4pzkA:
undetectable		 2br4E-4pzkA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb9 ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycolicibacterium
smegmatis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 LEU A  63
LEU A 104
GLY A  60
ALA A  86
ALA A  25
 None
 1.17A 2br4E-4qb9A:
undetectable		 2br4E-4qb9A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmg STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase) 		5 LEU A  86
LYS A  89
GLU A 121
ALA A 129
ALA A 156
 None
 1.14A 2br4E-4qmgA:
undetectable		 2br4E-4qmgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		5 LEU A  70
LEU A 200
GLY A 231
ASP A 240
ALA A 229
 None
 1.07A 2br4E-4r5zA:
3.2		 2br4E-4r5zA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 LEU A 254
LEU A 263
GLY A 162
ALA A  93
ALA A  57
 None
 1.09A 2br4E-4uozA:
undetectable		 2br4E-4uozA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg0 UNCHARACTERIZED
PROTEIN

(Bordetella
bronchiseptica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 LEU A 296
LEU A 324
GLY A 332
ALA A 331
ALA A 233
 None
 1.14A 2br4E-4xg0A:
undetectable		 2br4E-4xg0A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK

(Cupriavidus
necator) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 LEU A 129
LEU A 168
GLY A 163
TYR A 167
ALA A 146
 None
 1.05A 2br4E-5aa5A:
undetectable		 2br4E-5aa5A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A  32
LEU A  28
GLY A 358
ALA A 362
ALA A 410
 None
 1.12A 2br4E-5bp1A:
undetectable		 2br4E-5bp1A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 LEU A 423
LEU A 427
GLY A 398
TYR A 400
ALA A 392
 None
 1.09A 2br4E-5c3mA:
5.4		 2br4E-5c3mA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 5 LEU B   6
LEU B 131
GLY B  16
ALA B  19
ALA B  23
 None
MTA  B 401 ( 4.2A)
None
None
None
 1.18A 2br4E-5co4B:
2.7		 2br4E-5co4B:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA1

(Lactobacillus
delbrueckii) 		PF00005
(ABC_tran) 		5 LEU A 183
LEU A 167
ARG A 187
ASP A 266
ALA A 207
 None
 1.09A 2br4E-5d3mA:
undetectable		 2br4E-5d3mA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		5 LEU H 167
GLY H 162
ASP H 166
ALA H 133
ALA H 136
 None
 1.15A 2br4E-5fg9H:
undetectable		 2br4E-5fg9H:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		5 LEU A 968
LEU A 983
GLY A 958
ALA A 928
ALA A 926
 None
 1.06A 2br4E-5irmA:
undetectable		 2br4E-5irmA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		5 LEU A 528
LEU A 475
GLY A 555
ALA A 484
ALA A 488
 None
 0.99A 2br4E-5kqiA:
undetectable		 2br4E-5kqiA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nil MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF00005
(ABC_tran)
PF02687
(FtsX)
PF12704
(MacB_PCD) 		5 GLY J  41
ARG J 217
ARG J 223
ASP J 218
ALA J  42
 None
 1.06A 2br4E-5nilJ:
undetectable		 2br4E-5nilJ:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7o NOSK

(Streptomyces
actuosus) 		PF12697
(Abhydrolase_6) 		5 LEU A  64
LEU A 104
GLY A 100
ALA A 109
ALA A 113
 None
 1.16A 2br4E-5v7oA:
2.8		 2br4E-5v7oA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1y MERCURIC REDUCTASE

(Lysinibacillus
sphaericus) 		no annotation 5 LEU B 354
GLU B 114
GLY B  91
ALA B 218
ALA B 385
 FAD  B 601 (-4.6A)
FAD  B 601 (-2.6A)
FAD  B 601 (-3.3A)
FAD  B 601 ( 4.6A)
None
 1.04A 2br4E-5x1yB:
3.0		 2br4E-5x1yB:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xep CHITINASE-3-LIKE
PROTEIN 1

(Mus musculus) 		no annotation 5 LEU A  95
LEU A  67
GLY A  98
ALA A 139
ALA A 178
 None
 1.05A 2br4E-5xepA:
undetectable		 2br4E-5xepA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9u DNA GYRASE, SUBUNIT
B:SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
abortus) 		no annotation 5 LEU A 194
GLY A  13
ARG A  38
ASP A  60
ALA A  88
 NAI  A 301 (-3.3A)
NAI  A 301 (-3.1A)
NAI  A 301 (-3.4A)
NAI  A 301 (-3.4A)
NAI  A 301 (-3.7A)
 0.85A 2br4E-6b9uA:
undetectable		 2br4E-6b9uA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cr0 (S)-6-HYDROXYNICOTIN
E OXIDASE

(Shinella sp.
HZN7) 		no annotation 5 GLY A 290
ARG A  43
ASP A 289
ALA A 288
ALA A 381
 None
FAD  A 507 (-4.0A)
None
None
None
 1.07A 2br4E-6cr0A:
undetectable		 2br4E-6cr0A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft


(;
) 		no annotation
no annotation 		5 GLY A 373
ASP B 287
ASP A 405
ALA A 406
ALA A 398
 NAD  B 500 (-3.0A)
NAD  A 502 (-4.1A)
NAD  B 500 (-4.4A)
NAD  B 500 (-3.1A)
NAD  A 502 (-3.1A)
 1.15A 2br4E-6dftA:
2.5		 2br4E-6dftA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dvp HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE

(Drosophila
melanogaster) 		PF00790
(VHS)
PF01363
(FYVE) 		3 SER A   5
ASP A  31
CYH A  73
 None
 1.12A 2br4E-1dvpA:
undetectable		 2br4E-1dvpA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek2 EPOXIDE HYDROLASE

(Mus musculus) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		3 SER A 503
ASP A 495
CYH A 521
 None
 1.18A 2br4E-1ek2A:
1.3		 2br4E-1ek2A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inp INOSITOL
POLYPHOSPHATE
1-PHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		3 SER A 318
ASP A 334
CYH A 338
 None
 1.13A 2br4E-1inpA:
undetectable		 2br4E-1inpA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx7 HYPOTHETICAL PROTEIN
YCHN

(Escherichia
coli) 		PF02635
(DrsE) 		3 SER A  17
ASP A  44
CYH A  81
 None
 1.07A 2br4E-1jx7A:
undetectable		 2br4E-1jx7A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		3 SER A 285
ASP A 349
CYH A 398
 None
None
CIR  A 500 (-1.7A)
 1.14A 2br4E-1lxyA:
undetectable		 2br4E-1lxyA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 SER A 111
ASP A 147
CYH A 155
 PLP  A 430 ( 3.9A)
None
None
 1.18A 2br4E-1mlzA:
2.0		 2br4E-1mlzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK

(Escherichia
coli) 		PF02615
(Ldh_2) 		3 SER A  39
ASP A 172
CYH A 136
 None
 0.93A 2br4E-1nxuA:
undetectable		 2br4E-1nxuA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT

(Methylophilus
methylotrophus) 		PF01012
(ETF) 		3 SER C 123
ASP C  40
CYH C  76
 None
 0.99A 2br4E-1o94C:
undetectable		 2br4E-1o94C:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 SER A 421
ASP A 337
CYH A 345
 None
 1.03A 2br4E-1qgrA:
undetectable		 2br4E-1qgrA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 SER A   8
ASP A 151
CYH A 147
 None
GLA  A 500 (-3.0A)
GLA  A 500 (-4.5A)
 1.14A 2br4E-1s4eA:
undetectable		 2br4E-1s4eA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkl COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		3 SER A 238
ASP A 156
CYH A 193
 None
 0.94A 2br4E-1tklA:
undetectable		 2br4E-1tklA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt4 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF04107
(GCS2) 		3 SER A 329
ASP A  68
CYH A  66
 None
 1.07A 2br4E-1tt4A:
undetectable		 2br4E-1tt4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg0 B-PHYCOERYTHRIN BETA
CHAIN

(Rhodomonas sp.
CS24) 		PF00502
(Phycobilisome) 		3 SER C  46
ASP C  39
CYH C 158
 None
PEB  C 258 (-3.1A)
PEB  C 258 (-1.8A)
 0.99A 2br4E-1xg0C:
undetectable		 2br4E-1xg0C:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY

(Vibrio cholerae) 		PF00480
(ROK) 		3 SER A 348
ASP A 305
CYH A 287
 GOL  A 414 (-3.3A)
None
None
 1.04A 2br4E-1z05A:
undetectable		 2br4E-1z05A:
20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		3 SER A  95
ASP A 116
CYH A 139
 SAM  A 301 (-3.0A)
SAM  A 301 (-3.0A)
SAM  A 301 (-2.9A)
 0.40A 2br4E-2br4A:
35.2		 2br4E-2br4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dao TRANSCRIPTION FACTOR
ETV6

(Homo sapiens) 		PF00178
(Ets) 		3 SER A  20
ASP A  13
CYH A   8
 None
 1.08A 2br4E-2daoA:
undetectable		 2br4E-2daoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dej PROBABLE
GALACTOKINASE

(Pyrococcus
horikoshii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 SER A   6
ASP A 149
CYH A 145
 None
GLA  A 401 (-3.1A)
GLA  A 401 (-4.6A)
 1.07A 2br4E-2dejA:
undetectable		 2br4E-2dejA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4o PEPTIDE N-GLYCANASE

(Mus musculus) 		PF01841
(Transglut_core) 		3 SER A 371
ASP A 332
CYH A 306
 None
 1.06A 2br4E-2f4oA:
undetectable		 2br4E-2f4oA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0r NICOTINAMIDASE

(Saccharomyces
cerevisiae) 		PF00857
(Isochorismatase) 		3 SER A  19
ASP A  51
CYH A 167
 None
ZN  A 301 (-2.6A)
None
 0.91A 2br4E-2h0rA:
undetectable		 2br4E-2h0rA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3g BIOSYNTHETIC PROTEIN

(Bacillus
anthracis) 		PF03309
(Pan_kinase) 		3 SER X  63
ASP X 129
CYH X 137
 None
 1.08A 2br4E-2h3gX:
undetectable		 2br4E-2h3gX:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		3 SER A 283
ASP A 249
CYH A 159
 None
 1.04A 2br4E-2i7xA:
1.7		 2br4E-2i7xA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA

(Desulfovibrio
vulgaris) 		PF02335
(Cytochrom_C552) 		3 SER A 333
ASP A 318
CYH A 352
 HEM  A1002 (-2.5A)
HEM  C1004 ( 4.2A)
HEM  A1005 (-2.0A)
 1.15A 2br4E-2j7aA:
undetectable		 2br4E-2j7aA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 SER A 155
ASP A 413
CYH A 217
 BG6  A1002 ( 3.4A)
BG6  A1002 (-2.6A)
None
 1.13A 2br4E-2nztA:
undetectable		 2br4E-2nztA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		3 SER A 187
ASP A 179
CYH A 361
 None
 0.91A 2br4E-2o7pA:
undetectable		 2br4E-2o7pA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		3 SER A 254
ASP A  11
CYH A  15
 None
 1.12A 2br4E-2ob1A:
9.1		 2br4E-2ob1A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogj DIHYDROOROTASE

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		3 SER A 331
ASP A 262
CYH A 232
 None
 1.13A 2br4E-2ogjA:
undetectable		 2br4E-2ogjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 SER A 800
ASP A 579
CYH A 560
 None
GOL  A3007 (-2.6A)
None
 1.15A 2br4E-2okxA:
undetectable		 2br4E-2okxA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		3 SER A  56
ASP A 146
CYH A 180
 SAH  A 301 (-3.0A)
SAH  A 301 (-4.2A)
None
 0.89A 2br4E-2oy0A:
7.4		 2br4E-2oy0A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4h VESTITONE REDUCTASE

(Medicago sativa) 		PF01370
(Epimerase) 		3 SER X  24
ASP X 233
CYH X 253
 None
 0.75A 2br4E-2p4hX:
4.1		 2br4E-2p4hX:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 SER A 122
ASP A 169
CYH A 435
 None
ZN  A 501 (-1.9A)
None
 1.16A 2br4E-2qyvA:
undetectable		 2br4E-2qyvA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjh PHYCOERYTHRIN BETA
SUBUNIT

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		3 SER B  46
ASP B  39
CYH B 158
 None
PEB  B1158 (-3.3A)
PEB  B1158 (-1.6A)
 1.07A 2br4E-2vjhB:
undetectable		 2br4E-2vjhB:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa2 NON-STRUCTURAL
PROTEIN 5

(Modoc virus) 		PF01728
(FtsJ) 		3 SER A  57
ASP A 147
CYH A 182
 SAM  A1248 ( 4.7A)
SAM  A1248 (-3.7A)
None
 0.93A 2br4E-2wa2A:
7.1		 2br4E-2wa2A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqp POLYSIALIC ACID
CAPSULE BIOSYNTHESIS
PROTEIN SIAC

(Neisseria
meningitidis) 		PF03102
(NeuB)
PF08666
(SAF) 		3 SER A 154
ASP A 214
CYH A 250
 WQP  A1350 (-2.5A)
None
None
 1.16A 2br4E-2wqpA:
undetectable		 2br4E-2wqpA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		3 SER B 212
ASP B 157
CYH B 160
 None
ANP  B 432 (-2.9A)
None
 0.93A 2br4E-2wtkB:
undetectable		 2br4E-2wtkB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anv D-SERINE DEHYDRATASE

(Gallus gallus) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		3 SER A 226
ASP A 247
CYH A 349
 None
None
ZN  A 451 (-2.3A)
 1.05A 2br4E-3anvA:
undetectable		 2br4E-3anvA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 SER A 576
ASP A 795
CYH A 739
 None
 0.93A 2br4E-3bg9A:
undetectable		 2br4E-3bg9A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		3 SER A 717
ASP A 679
CYH A 804
 GOL  A 825 ( 4.9A)
None
None
 1.14A 2br4E-3cf4A:
3.4		 2br4E-3cf4A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		3 SER A1333
ASP A1032
CYH A 116
 None
 1.10A 2br4E-3cmuA:
undetectable		 2br4E-3cmuA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cos ALCOHOL
DEHYDROGENASE 4

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 SER A 304
ASP A 273
CYH A 295
 None
 0.81A 2br4E-3cosA:
4.6		 2br4E-3cosA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hu5 ISOCHORISMATASE
FAMILY PROTEIN

(Desulfovibrio
vulgaris) 		PF00857
(Isochorismatase) 		3 SER A 162
ASP A  15
CYH A  82
 None
 1.13A 2br4E-3hu5A:
3.3		 2br4E-3hu5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2n WD REPEAT-CONTAINING
PROTEIN 92

(Homo sapiens) 		PF00400
(WD40) 		3 SER A 214
ASP A 328
CYH A 337
 None
 0.98A 2br4E-3i2nA:
undetectable		 2br4E-3i2nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		3 SER A1067
ASP A 868
CYH A1197
 None
 1.15A 2br4E-3ikmA:
undetectable		 2br4E-3ikmA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq3 LOMBRICINE KINASE

(Urechis caupo) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 SER A 164
ASP A 197
CYH A 133
 None
 1.17A 2br4E-3jq3A:
undetectable		 2br4E-3jq3A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lh5 TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		3 SER A 758
ASP A 655
CYH A 744
 None
 1.12A 2br4E-3lh5A:
undetectable		 2br4E-3lh5A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		3 SER A  56
ASP A 146
CYH A 180
 SFG  A 301 (-2.6A)
SFG  A 301 (-3.8A)
None
 0.92A 2br4E-3lkzA:
6.7		 2br4E-3lkzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE

(Idiomarina
loihiensis) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		3 SER A  36
ASP A 225
CYH A 192
 None
 1.15A 2br4E-3llxA:
undetectable		 2br4E-3llxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oy2 GLYCOSYLTRANSFERASE
B736L

(Paramecium
bursaria
Chlorella virus
NY2A) 		no annotation 3 SER A 290
ASP A 309
CYH A 143
 None
 1.13A 2br4E-3oy2A:
undetectable		 2br4E-3oy2A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phg SHIKIMATE
DEHYDROGENASE

(Helicobacter
pylori) 		PF08501
(Shikimate_dh_N) 		3 SER A 112
ASP A 105
CYH A  86
 None
 1.13A 2br4E-3phgA:
4.8		 2br4E-3phgA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00342
(PGI) 		3 SER A 173
ASP A 338
CYH A 334
 None
 1.02A 2br4E-3q88A:
undetectable		 2br4E-3q88A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE

(Bartonella
henselae) 		PF00701
(DHDPS) 		3 SER A 253
ASP A 192
CYH A 207
 None
 1.18A 2br4E-3si9A:
undetectable		 2br4E-3si9A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsr RIBONUCLEASE
INHIBITOR

(Mus musculus) 		PF13516
(LRR_6) 		3 SER E  57
ASP E 117
CYH E 147
 None
 1.15A 2br4E-3tsrE:
undetectable		 2br4E-3tsrE:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uj2 ENOLASE 1

(Anaerostipes
caccae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 SER A 278
ASP A 217
CYH A 263
 None
 1.00A 2br4E-3uj2A:
undetectable		 2br4E-3uj2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		3 SER B 258
ASP B 682
CYH B 685
 None
 1.08A 2br4E-3v0aB:
undetectable		 2br4E-3v0aB:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v57 PHYCOERYTHRIN BETA
SUBUNIT

(Porphyridium
purpureum) 		PF00502
(Phycobilisome) 		3 SER B  46
ASP B  39
CYH B 158
 None
PEB  B 204 (-3.3A)
PEB  B 204 ( 1.7A)
 1.15A 2br4E-3v57B:
undetectable		 2br4E-3v57B:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		3 SER A 551
ASP A 568
CYH A 598
 None
SAM  A 802 (-2.9A)
SAM  A 802 (-3.3A)
 0.90A 2br4E-3v8vA:
8.8		 2br4E-3v8vA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		3 SER A 551
ASP A 615
CYH A 696
 None
 0.99A 2br4E-3v8vA:
8.8		 2br4E-3v8vA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a14 KINESIN-LIKE PROTEIN
KIF7

(Homo sapiens) 		PF00225
(Kinesin) 		3 SER A 253
ASP A 329
CYH A  34
 None
 1.00A 2br4E-4a14A:
undetectable		 2br4E-4a14A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2l TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		3 SER A 552
ASP A 594
CYH A 609
 None
None
PGE  A1785 ( 4.2A)
 1.09A 2br4E-4a2lA:
undetectable		 2br4E-4a2lA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl0 CELL CYCLE ARREST
PROTEIN BUB3

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 SER A 212
ASP A 157
CYH A 108
 None
 0.90A 2br4E-4bl0A:
undetectable		 2br4E-4bl0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw9 THIOREDOXIN

(Entamoeba
histolytica) 		PF00085
(Thioredoxin) 		3 SER A  38
ASP A  57
CYH A  65
 None
 1.03A 2br4E-4cw9A:
undetectable		 2br4E-4cw9A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eme M18 ASPARTYL
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF02127
(Peptidase_M18) 		3 SER A 392
ASP A 378
CYH A  27
 None
 0.89A 2br4E-4emeA:
undetectable		 2br4E-4emeA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffl PYLC

(Methanosarcina
barkeri) 		PF02655
(ATP-grasp_3) 		3 SER A  20
ASP A  65
CYH A  89
 None
 1.02A 2br4E-4fflA:
undetectable		 2br4E-4fflA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		3 SER A 111
ASP A  80
CYH A  70
 None
 1.13A 2br4E-4i2wA:
undetectable		 2br4E-4i2wA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix3 MSSTT7D PROTEIN

(Micromonas
commoda) 		PF00069
(Pkinase) 		3 SER A 402
ASP A 396
CYH A 345
 None
 0.95A 2br4E-4ix3A:
undetectable		 2br4E-4ix3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkm BETA-GLUCURONIDASE

(Clostridium
perfringens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 SER A 415
ASP A 458
CYH A 496
 None
 1.15A 2br4E-4jkmA:
undetectable		 2br4E-4jkmA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE

(Schizosaccharomyces
pombe) 		PF01746
(tRNA_m1G_MT) 		3 SER A 114
ASP A 207
CYH A 215
 None
SAH  A 401 (-3.0A)
SAH  A 401 (-3.3A)
 1.03A 2br4E-4jwhA:
2.5		 2br4E-4jwhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii) 		PF00398
(RrnaAD) 		3 SER A 266
ASP A 260
CYH A 251
 None
 0.99A 2br4E-4jxjA:
9.5		 2br4E-4jxjA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF02277
(DBI_PRT) 		3 SER A 269
ASP A 242
CYH A 134
 None
 0.92A 2br4E-4kqkA:
undetectable		 2br4E-4kqkA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lad E3 UBIQUITIN-PROTEIN
LIGASE AMFR

(Homo sapiens) 		PF13639
(zf-RING_2) 		3 SER B 363
ASP B 340
CYH B 344
 None
OXL  B 703 (-4.9A)
None
 1.10A 2br4E-4ladB:
undetectable		 2br4E-4ladB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmx CRYPTOPHYTE
PHYCOERYTHRIN (BETA
CHAIN)

(Hemiselmis
andersenii) 		PF00502
(Phycobilisome) 		3 SER B  46
ASP B  39
CYH B 158
 None
PEB  B 202 (-3.3A)
PEB  B 202 (-1.8A)
 0.86A 2br4E-4lmxB:
undetectable		 2br4E-4lmxB:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6s C-PHYCOCYANIN BETA
SUBUNIT

(Thermosynechococcus
vulcanus) 		PF00502
(Phycobilisome) 		3 SER B  46
ASP B  39
CYH B 155
 None
CYC  B 202 (-3.0A)
CYC  B 202 (-1.8A)
 1.12A 2br4E-4n6sB:
undetectable		 2br4E-4n6sB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzj PUTATIVE
ALPHA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF05345
(He_PIG)
PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2) 		3 SER A  59
ASP A 400
CYH A 375
 None
 0.86A 2br4E-4nzjA:
undetectable		 2br4E-4nzjA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		3 SER B  57
ASP B 117
CYH B 147
 None
 1.12A 2br4E-4peqB:
undetectable		 2br4E-4peqB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r94 NON-STRUCTURAL
PROTEIN NS1

(Rodent
protoparvovirus
1) 		PF12433
(PV_NSP1) 		3 SER A  70
ASP A  91
CYH A 128
 None
 0.99A 2br4E-4r94A:
undetectable		 2br4E-4r94A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE

(Brucella
abortus) 		PF01370
(Epimerase) 		3 SER A 309
ASP A 224
CYH A 120
 None
 1.04A 2br4E-4twrA:
5.2		 2br4E-4twrA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 SER A  31
ASP A 105
CYH A 381
 None
 1.12A 2br4E-4uaqA:
2.2		 2br4E-4uaqA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		3 SER B 225
ASP B 647
CYH B 650
 None
 0.96A 2br4E-4zktB:
undetectable		 2br4E-4zktB:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		3 SER A1515
ASP A1372
CYH A1414
 None
 0.97A 2br4E-5a22A:
9.0		 2br4E-5a22A:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b13 PHYCOERYTHRIN BETA
SUBUNIT

(Palmaria
palmata) 		PF00502
(Phycobilisome) 		3 SER G  46
ASP G  39
CYH G 158
 None
CYC  G 202 (-3.2A)
CYC  G 202 (-1.7A)
 1.09A 2br4E-5b13G:
undetectable		 2br4E-5b13G:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola) 		PF01344
(Kelch_1)
PF09118
(DUF1929) 		3 SER A 127
ASP A 202
CYH A 162
 None
NAG  A 502 (-3.2A)
None
 0.95A 2br4E-5c92A:
undetectable		 2br4E-5c92A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4m HYDROXYNITRILE LYASE

(Davallia
tyermannii) 		no annotation 3 SER A 119
ASP A  85
CYH A  73
 HBA  A 201 ( 4.1A)
None
HBA  A 201 ( 4.4A)
 1.13A 2br4E-5e4mA:
undetectable		 2br4E-5e4mA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		3 SER A 262
ASP A 203
CYH A 236
 SAH  A 500 (-4.1A)
SAH  A 500 ( 4.8A)
None
 1.17A 2br4E-5e9wA:
9.0		 2br4E-5e9wA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		3 SER A 922
ASP A 911
CYH A1593
 None
 0.96A 2br4E-5h64A:
undetectable		 2br4E-5h64A:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k50 L-THREONINE
3-DEHYDROGENASE

(Trypanosoma
brucei) 		no annotation 3 SER A1019
ASP A1035
CYH A1056
 None
NAD  A1401 (-2.8A)
NAD  A1401 (-3.7A)
 0.83A 2br4E-5k50A:
4.9		 2br4E-5k50A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		3 SER A 733
ASP A 881
CYH A 701
 None
 0.99A 2br4E-5m5pA:
2.5		 2br4E-5m5pA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 SER A 414
ASP A 347
CYH A 386
 None
 1.00A 2br4E-5n28A:
undetectable		 2br4E-5n28A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7y ANTI-SIGMA-G FACTOR
GIN

(Bacillus
subtilis) 		no annotation 3 SER A  39
ASP A  32
CYH A  14
 None
None
ZN  A 101 (-2.3A)
 1.15A 2br4E-5n7yA:
undetectable		 2br4E-5n7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 3 SER A  96
ASP A 548
CYH A 521
 FAD  A 601 ( 4.1A)
FAD  A 601 (-4.5A)
None
 1.07A 2br4E-5nitA:
undetectable		 2br4E-5nitA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi) 		PF00883
(Peptidase_M17) 		3 SER A 160
ASP A 121
CYH A 116
 None
 0.96A 2br4E-5ntfA:
undetectable		 2br4E-5ntfA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS

(Erwinia
amylovora) 		no annotation 3 SER A 216
ASP A 325
CYH A 301
 PLP  A 601 ( 3.9A)
PLP  A 601 (-3.0A)
None
 1.18A 2br4E-5o5cA:
2.6		 2br4E-5o5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 SER A 394
ASP A 542
CYH A 540
 None
 0.99A 2br4E-5oljA:
undetectable		 2br4E-5oljA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3j INOSITOL
MONOPHOSPHATASE

(Medicago
truncatula) 		PF00459
(Inositol_P) 		3 SER A 323
ASP A 209
CYH A 207
 None
 1.16A 2br4E-5t3jA:
undetectable		 2br4E-5t3jA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B
TUNGSTEN-CONTAINING
FORMYLMETHANOFURAN
DEHYDROGENASE 2
SUBUNIT C

(Methanothermobacter
sp. CaT2;
Methanothermobacter
wolfeii) 		PF00384
(Molybdopterin)
PF01493
(GXGXG) 		3 SER C 115
ASP B 328
CYH B 309
 None
 1.15A 2br4E-5t5iC:
undetectable		 2br4E-5t5iC:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 3 SER A 132
ASP A 100
CYH A 104
 A3P  A 301 (-2.5A)
OAQ  A 302 (-2.5A)
None
 1.16A 2br4E-5tiwA:
undetectable		 2br4E-5tiwA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8z CAROTENOID OXYGENASE
1

(Neurospora
crassa) 		PF03055
(RPE65) 		3 SER A 167
ASP A 217
CYH A 266
 None
 1.16A 2br4E-5u8zA:
undetectable		 2br4E-5u8zA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(environmental
samples) 		PF00202
(Aminotran_3) 		3 SER A 111
ASP A 147
CYH A 155
 LLP  A 274 ( 4.1A)
None
None
 1.11A 2br4E-5uc7A:
2.4		 2br4E-5uc7A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 3 SER A 814
ASP A 970
CYH A 979
 None
 1.00A 2br4E-5vhaA:
3.5		 2br4E-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES

(Corynebacterium
glutamicum) 		PF01053
(Cys_Met_Meta_PP) 		3 SER A  14
ASP A 259
CYH A 262
 None
 0.92A 2br4E-5x5hA:
undetectable		 2br4E-5x5hA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		3 SER w 113
ASP w 223
CYH w  67
 None
 1.11A 2br4E-5xtdw:
undetectable		 2br4E-5xtdw:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cvq APRATAXIN

(Homo sapiens) 		no annotation 3 SER A 174
ASP A 193
CYH A 272
 AMP  A 401 (-2.2A)
AMP  A 401 (-2.2A)
BME  A 404 (-2.7A)
 1.03A 2br4E-6cvqA:
undetectable		 2br4E-6cvqA:
undetectable