SIMILAR PATTERNS OF AMINO ACIDS FOR 2BR4_D_SAMD301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1as4 ANTICHYMOTRYPSIN

(Homo sapiens) 		PF00079
(Serpin) 		3 LYS A 174
ASP A  47
ASP A 296
 None
 0.92A 2br4D-1as4A:
undetectable		 2br4D-1as4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp2 NITROGENASE IRON
PROTEIN

(Clostridium
pasteurianum) 		PF00142
(Fer4_NifH) 		3 LYS A  14
ASP A  58
ASP A  38
 None
 0.69A 2br4D-1cp2A:
undetectable		 2br4D-1cp2A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0k DNA HELICASE

(Escherichia
virus T7) 		PF03796
(DnaB_C) 		3 LYS A 450
ASP A 526
ASP A 497
 None
 1.00A 2br4D-1e0kA:
undetectable		 2br4D-1e0kA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3e ALCOHOL
DEHYDROGENASE, CLASS
II

(Mus musculus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 LYS A  98
ASP A 336
ASP A 328
 None
 0.94A 2br4D-1e3eA:
5.3		 2br4D-1e3eA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 LYS A 822
ASP A 805
ASP A 922
 None
 0.97A 2br4D-1jx2A:
undetectable		 2br4D-1jx2A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 LYS A 371
ASP A 232
ASP A 228
 None
 0.84A 2br4D-1kblA:
undetectable		 2br4D-1kblA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		3 LYS A 233
ASP A 446
ASP A 439
 None
 0.77A 2br4D-1lnsA:
undetectable		 2br4D-1lnsA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oaz THIOREDOXIN 1

(Escherichia
coli) 		PF00085
(Thioredoxin) 		3 LYS A  50
ASP A  15
ASP A  26
 None
 0.92A 2br4D-1oazA:
undetectable		 2br4D-1oazA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		3 LYS A 290
ASP A 347
ASP A 326
 None
NVA  A1818 (-3.1A)
None
 0.90A 2br4D-1obhA:
undetectable		 2br4D-1obhA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0u BSTDEAD

(Geobacillus
stearothermophilus) 		PF00270
(DEAD) 		3 LYS A 201
ASP A 139
ASP A 172
 None
 0.99A 2br4D-1q0uA:
2.8		 2br4D-1q0uA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjl DNAK SUPPRESSOR
PROTEIN

(Escherichia
coli) 		PF01258
(zf-dskA_traR) 		3 LYS A 101
ASP A 137
ASP A 133
 None
 0.91A 2br4D-1tjlA:
undetectable		 2br4D-1tjlA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2x TRNA (GM18)
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C) 		3 LYS A  90
ASP A 104
ASP A 137
 None
 0.94A 2br4D-1v2xA:
2.1		 2br4D-1v2xA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vff BETA-GLUCOSIDASE

(Pyrococcus
horikoshii) 		PF00232
(Glyco_hydro_1) 		3 LYS A 294
ASP A 221
ASP A 289
 None
 0.87A 2br4D-1vffA:
undetectable		 2br4D-1vffA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT
IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3)
PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		3 LYS B 401
ASP C 215
ASP B 441
 None
 0.97A 2br4D-1wa5B:
undetectable		 2br4D-1wa5B:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh8 OXIDOREDUCTASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 LYS A 101
ASP A 211
ASP A 186
 NAP  A 400 (-3.2A)
NA  A 329 (-2.8A)
NAP  A 400 ( 4.7A)
 0.98A 2br4D-1zh8A:
3.0		 2br4D-1zh8A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 LYS A1110
ASP A 716
ASP A1120
 None
 1.01A 2br4D-2b39A:
undetectable		 2br4D-2b39A:
9.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		3 LYS A  65
ASP A 138
ASP A 160
 SAM  A 301 (-2.6A)
SAM  A 301 (-3.7A)
MG  A 300 ( 3.6A)
 0.19A 2br4D-2br4A:
34.9		 2br4D-2br4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hev TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER 4
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 4

(Homo sapiens;
Homo sapiens) 		no annotation
PF00020
(TNFR_c6) 		3 LYS R  79
ASP F  90
ASP F 147
 None
 0.97A 2br4D-2hevR:
undetectable		 2br4D-2hevR:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7d 5'(3')-DEOXYRIBONUCL
EOTIDASE, CYTOSOLIC
TYPE

(Homo sapiens) 		PF06941
(NT5C) 		3 LYS A 134
ASP A 185
ASP A 144
 ALF  A 400 (-2.8A)
None
ALF  A 400 ( 4.2A)
 0.99A 2br4D-2i7dA:
undetectable		 2br4D-2i7dA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 LYS X 547
ASP X 349
ASP X 549
 None
 0.94A 2br4D-2iv2X:
2.7		 2br4D-2iv2X:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkm MORTALITY FACTOR
4-LIKE PROTEIN 1

(Homo sapiens) 		PF05712
(MRG) 		3 LYS B 188
ASP B 208
ASP B 196
 None
 0.81A 2br4D-2lkmB:
undetectable		 2br4D-2lkmB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1a IRON-REGULATED
SURFACE DETERMINANT
PROTEIN A

(Staphylococcus
aureus) 		PF05031
(NEAT) 		3 LYS A  35
ASP A  92
ASP A  40
 None
 0.89A 2br4D-2o1aA:
undetectable		 2br4D-2o1aA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8e PPM1B BETA ISOFORM
VARIANT 6

(Homo sapiens) 		PF00481
(PP2C) 		3 LYS A 243
ASP A 114
ASP A  60
 OCS  A 242 (-3.0A)
None
MG  A 306 (-2.5A)
 0.99A 2br4D-2p8eA:
undetectable		 2br4D-2p8eA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE

(Streptococcus
sp.) 		PF01266
(DAO)
PF16901
(DAO_C) 		3 LYS A 279
ASP A 337
ASP A 322
 None
 0.89A 2br4D-2rghA:
2.1		 2br4D-2rghA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rh7 GREEN FLUORESCENT
PROTEIN

(Renilla
reniformis) 		PF01353
(GFP) 		3 LYS A 202
ASP A 101
ASP A  59
 None
 0.98A 2br4D-2rh7A:
undetectable		 2br4D-2rh7A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vat ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE

(Acremonium
chrysogenum) 		PF00561
(Abhydrolase_1) 		3 LYS A 300
ASP A 135
ASP A 126
 None
 0.67A 2br4D-2vatA:
undetectable		 2br4D-2vatA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		3 LYS A  24
ASP A 239
ASP A 288
 None
SAH  A 376 ( 4.2A)
SAH  A 376 (-4.1A)
 0.97A 2br4D-2zwvA:
8.9		 2br4D-2zwvA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		3 LYS A 414
ASP A 398
ASP A 393
 None
 0.97A 2br4D-3afgA:
undetectable		 2br4D-3afgA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwv PUTATIVE
5'(3')-DEOXYRIBONUCL
EOTIDASE

(Staphylococcus
epidermidis) 		PF06941
(NT5C) 		3 LYS A 124
ASP A 169
ASP A 134
 None
None
MG  A 300 ( 4.6A)
 0.82A 2br4D-3bwvA:
undetectable		 2br4D-3bwvA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjm PUTATIVE
BETA-LACTAMASE

(Enterococcus
faecalis) 		PF13354
(Beta-lactamase2) 		3 LYS A 198
ASP A 267
ASP A 211
 None
 1.00A 2br4D-3cjmA:
undetectable		 2br4D-3cjmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8k PROTEIN PHOSPHATASE
2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		3 LYS A 311
ASP A 151
ASP A 168
 None
 0.74A 2br4D-3d8kA:
undetectable		 2br4D-3d8kA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk4 RUBISCO-LIKE PROTEIN

(Bacillus cereus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 LYS A 118
ASP A 354
ASP A 325
 None
 0.89A 2br4D-3fk4A:
undetectable		 2br4D-3fk4A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III

(Xanthomonas
oryzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 LYS A 307
ASP A  56
ASP A  15
 None
 0.99A 2br4D-3fk5A:
undetectable		 2br4D-3fk5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		3 LYS A 283
ASP A 311
ASP A 301
 None
 0.86A 2br4D-3iecA:
undetectable		 2br4D-3iecA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksy SON OF SEVENLESS
HOMOLOG 1

(Homo sapiens) 		PF00125
(Histone)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		3 LYS A 728
ASP A 293
ASP A 285
 None
 0.98A 2br4D-3ksyA:
undetectable		 2br4D-3ksyA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		3 LYS A 221
ASP A  56
ASP A  76
 None
 0.94A 2br4D-3kv6A:
undetectable		 2br4D-3kv6A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm8 THIAMINE
PYROPHOSPHOKINASE

(Bacillus
subtilis) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		3 LYS A 119
ASP A  51
ASP A  83
 None
MG  A 225 (-3.8A)
None
 0.97A 2br4D-3lm8A:
undetectable		 2br4D-3lm8A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		3 LYS A 233
ASP A 208
ASP A 338
 None
 0.87A 2br4D-3lq1A:
3.3		 2br4D-3lq1A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		3 LYS A 428
ASP A 174
ASP A 305
 None
 0.94A 2br4D-3odmA:
undetectable		 2br4D-3odmA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdd GLYCOSIDE HYDROLASE,
FAMILY 9

(Ruminiclostridium
thermocellum) 		no annotation 3 LYS A  87
ASP A 128
ASP A 165
 None
 0.94A 2br4D-3pddA:
undetectable		 2br4D-3pddA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		3 LYS A 190
ASP A  34
ASP A  38
 None
 0.99A 2br4D-3q9oA:
undetectable		 2br4D-3q9oA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Alicyclobacillus
acidocaldarius) 		PF13472
(Lipase_GDSL_2) 		3 LYS A  19
ASP A  92
ASP A  17
 CSO  A  18 ( 3.2A)
None
CSO  A  18 ( 3.9A)
 1.00A 2br4D-3rjtA:
2.7		 2br4D-3rjtA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssm METHYLTRANSFERASE

(Micromonospora
griseorubida) 		no annotation 3 LYS A 175
ASP A 252
ASP A 275
 SAH  A 601 (-3.1A)
SAH  A 601 (-3.6A)
MG  A 501 ( 2.8A)
 0.90A 2br4D-3ssmA:
12.4		 2br4D-3ssmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sub ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN

(Plasmodium
falciparum) 		PF01412
(ArfGap) 		3 LYS A 100
ASP A  31
ASP A  24
 None
 1.02A 2br4D-3subA:
undetectable		 2br4D-3subA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		3 LYS A 545
ASP A 599
ASP A 593
 None
 1.02A 2br4D-3texA:
undetectable		 2br4D-3texA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL

(Trypanosoma
brucei) 		PF01786
(AOX) 		3 LYS A 295
ASP A  56
ASP A  61
 None
 0.94A 2br4D-3vvaA:
undetectable		 2br4D-3vvaA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII

(Pseudoxanthomonas
mexicana) 		PF10459
(Peptidase_S46) 		3 LYS A 609
ASP A 336
ASP A 214
 None
 0.90A 2br4D-3wonA:
undetectable		 2br4D-3wonA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwp (S)-HYDROXYNITRILE
LYASE

(Baliospermum
montanum) 		PF00561
(Abhydrolase_1) 		3 LYS A  21
ASP A 150
ASP A 165
 CIT  A 301 ( 4.9A)
None
None
 0.72A 2br4D-3wwpA:
2.2		 2br4D-3wwpA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 LYS B1690
ASP B1670
ASP B1700
 None
 0.90A 2br4D-3zefB:
undetectable		 2br4D-3zefB:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		3 LYS A 613
ASP A 799
ASP A 712
 None
 0.98A 2br4D-3zgbA:
undetectable		 2br4D-3zgbA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak9 CPFTSY

(Physcomitrella
patens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		3 LYS A 207
ASP A 338
ASP A 367
 None
 0.87A 2br4D-4ak9A:
undetectable		 2br4D-4ak9A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens;
Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		3 LYS B 384
ASP A 554
ASP A 560
 None
 1.01A 2br4D-4cakB:
undetectable		 2br4D-4cakB:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d28 CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 LYS A 259
ASP A 143
ASP A 120
 None
 0.99A 2br4D-4d28A:
undetectable		 2br4D-4d28A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Escherichia
coli;
Candida
albicans) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		3 LYS A 645
ASP A-163
ASP A 515
 None
 0.89A 2br4D-4h1gA:
undetectable		 2br4D-4h1gA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr6 LECTIN
LECTIN

(Trichosanthes
anguina;
Trichosanthes
anguina) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		3 LYS B 179
ASP C 236
ASP C 146
 None
AMG  C 302 (-2.9A)
None
 0.99A 2br4D-4hr6B:
undetectable		 2br4D-4hr6B:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jd0 NUCLEOTIDYL
TRANSFERASE

(Thermotoga
maritima) 		PF00483
(NTP_transferase) 		3 LYS A 141
ASP A  30
ASP A 223
 None
 0.91A 2br4D-4jd0A:
undetectable		 2br4D-4jd0A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 LYS A 577
ASP A 436
ASP A 589
 None
 0.92A 2br4D-4jgvA:
undetectable		 2br4D-4jgvA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jja HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		3 LYS A 366
ASP A 129
ASP A 169
 None
 0.90A 2br4D-4jjaA:
3.0		 2br4D-4jjaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyl ENOYL-COA HYDRATASE

(Thermoplasma
volcanium) 		PF00378
(ECH_1) 		3 LYS A 194
ASP A 180
ASP A 190
 None
 0.87A 2br4D-4jylA:
undetectable		 2br4D-4jylA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8n PDZ DOMAIN PROTEIN

(Parabacteroides
distasonis) 		PF00595
(PDZ)
PF13590
(DUF4136) 		3 LYS A 324
ASP A 343
ASP A 127
 None
 0.87A 2br4D-4l8nA:
undetectable		 2br4D-4l8nA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 LYS A 487
ASP A  69
ASP A  23
 None
 0.83A 2br4D-4na3A:
undetectable		 2br4D-4na3A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		3 LYS B 345
ASP B 450
ASP B 389
 None
 0.95A 2br4D-4nfuB:
undetectable		 2br4D-4nfuB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqg GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
pneumoniae) 		PF00534
(Glycos_transf_1) 		3 LYS A  30
ASP A 313
ASP A 309
 None
 0.96A 2br4D-4pqgA:
3.2		 2br4D-4pqgA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q58 PLECTIN

(Homo sapiens) 		PF00307
(CH) 		3 LYS A  46
ASP A 189
ASP A 240
 None
 1.01A 2br4D-4q58A:
undetectable		 2br4D-4q58A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlz SJCHGC07024 PROTEIN

(Schistosoma
japonicum) 		PF00719
(Pyrophosphatase) 		3 LYS A 191
ASP A 105
ASP A 145
 None
None
CO  A 404 (-3.2A)
 0.83A 2br4D-4qlzA:
undetectable		 2br4D-4qlzA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmp ALLOPHYCOCYANIN

(Phormidium
rubidum) 		PF00502
(Phycobilisome) 		3 LYS A   6
ASP A 154
ASP A 100
 None
 0.98A 2br4D-4rmpA:
undetectable		 2br4D-4rmpA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF04551
(GcpE) 		3 LYS A  72
ASP A 197
ASP A 107
 None
 1.00A 2br4D-4s38A:
undetectable		 2br4D-4s38A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		3 LYS A 573
ASP A 507
ASP A 502
 None
 0.87A 2br4D-4txgA:
undetectable		 2br4D-4txgA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN A CHAIN
GLOBIN B CHAIN

(Glossoscolex
paulistus;
Glossoscolex
paulistus) 		PF00042
(Globin)
PF00042
(Globin) 		3 LYS B  12
ASP A  60
ASP B  79
 None
 1.00A 2br4D-4u8uB:
undetectable		 2br4D-4u8uB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylq COAGULATION FACTOR
VII

(Homo sapiens) 		PF00089
(Trypsin) 		3 LYS H  16
ASP H  60
ASP H 194
 None
0Z7  H 501 ( 4.2A)
None
 0.95A 2br4D-4ylqH:
undetectable		 2br4D-4ylqH:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A

(Thermotoga
maritima;
Thermotoga
maritima) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
PF10418
(DHODB_Fe-S_bind)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		3 LYS A 197
ASP B 346
ASP A 254
 None
 0.98A 2br4D-4yryA:
3.6		 2br4D-4yryA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		3 LYS A 234
ASP A 116
ASP A 206
 None
 0.91A 2br4D-5a2aA:
undetectable		 2br4D-5a2aA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens;
Homo sapiens) 		PF12859
(ANAPC1)
PF12862
(ANAPC5) 		3 LYS O 566
ASP A  90
ASP A  86
 None
 0.88A 2br4D-5a31O:
undetectable		 2br4D-5a31O:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT E

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF01399
(PCI)
PF05470
(eIF-3c_N)
PF01399
(PCI)
PF09440
(eIF3_N) 		3 LYS E 359
ASP C 814
ASP E 306
 None
 0.97A 2br4D-5a5tE:
undetectable		 2br4D-5a5tE:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9n B-1,4-ENDOGLUCANASE

(Prevotella
bryantii) 		PF00150
(Cellulase) 		3 LYS A 214
ASP A 253
ASP A 241
 XYS  A 408 ( 2.9A)
None
XYS  A 408 ( 3.4A)
 1.01A 2br4D-5d9nA:
undetectable		 2br4D-5d9nA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 3 LYS A 284
ASP A 365
ASP A 243
 None
 0.97A 2br4D-5f75A:
undetectable		 2br4D-5f75A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcr COMPLEMENT FACTOR D

(Mus musculus) 		PF00089
(Trypsin) 		3 LYS A  16
ASP A  60
ASP A 194
 None
 0.91A 2br4D-5fcrA:
undetectable		 2br4D-5fcrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		3 LYS A 616
ASP A 802
ASP A 715
 None
 0.96A 2br4D-5fdnA:
undetectable		 2br4D-5fdnA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fly FERRICHROME-BINDING
PERIPLASMIC PROTEIN

(Staphylococcus
pseudintermedius) 		PF01497
(Peripla_BP_2) 		3 LYS A  68
ASP A 253
ASP A  54
 None
 0.99A 2br4D-5flyA:
2.2		 2br4D-5flyA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 LYS C 620
ASP A 141
ASP C  23
 None
 1.01A 2br4D-5g5gC:
undetectable		 2br4D-5g5gC:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		3 LYS A 239
ASP A 113
ASP A 251
 None
 0.74A 2br4D-5g5zA:
undetectable		 2br4D-5g5zA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnc AVH146

(Phytophthora
sojae) 		no annotation 3 LYS A 399
ASP A 325
ASP A 360
 None
 0.99A 2br4D-5gncA:
undetectable		 2br4D-5gncA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvt PLASMA KALLIKREIN

(Mus musculus) 		no annotation 3 LYS A  16
ASP A  60
ASP A 194
 None
 0.93A 2br4D-5gvtA:
undetectable		 2br4D-5gvtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		3 LYS A 486
ASP A 548
ASP A 564
 None
 0.95A 2br4D-5hp5A:
undetectable		 2br4D-5hp5A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		3 LYS A1534
ASP A1646
ASP A1633
 None
 0.89A 2br4D-5i6gA:
undetectable		 2br4D-5i6gA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iww MULTIPLE ORGANELLAR
RNA EDITING FACTOR
9, CHLOROPLASTIC
PLS9-PPR

(Arabidopsis
thaliana;
unidentified) 		no annotation
PF12854
(PPR_1)
PF13041
(PPR_2) 		3 LYS D 181
ASP A 145
ASP A 164
 None
 0.96A 2br4D-5iwwD:
undetectable		 2br4D-5iwwD:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		3 LYS B1390
ASP B 973
ASP B 965
 NAG  B1509 ( 4.7A)
None
None
 0.81A 2br4D-5jpnB:
undetectable		 2br4D-5jpnB:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Legionella
pneumophila) 		PF00290
(Trp_syntA) 		3 LYS A 201
ASP A 266
ASP A 228
 None
 0.94A 2br4D-5k9xA:
undetectable		 2br4D-5k9xA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li8 PUTATIVE CYTOCHROME
P450 126

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 LYS A 213
ASP A 124
ASP A 220
 None
 0.90A 2br4D-5li8A:
undetectable		 2br4D-5li8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 3 LYS D 425
ASP D 335
ASP D 504
 None
 0.98A 2br4D-5llyD:
undetectable		 2br4D-5llyD:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5log PUTATIVE
O-METHYLTRANSFERASE

(Myxococcus
xanthus) 		PF01596
(Methyltransf_3) 		3 LYS A 196
ASP A 119
ASP A 149
 None
SAH  A1001 (-3.8A)
None
 0.95A 2br4D-5logA:
12.6		 2br4D-5logA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		3 LYS A 512
ASP A 733
ASP A 469
 None
 1.01A 2br4D-5n8oA:
undetectable		 2br4D-5n8oA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 3 LYS A 284
ASP A 365
ASP A 243
 None
 0.94A 2br4D-5oexA:
undetectable		 2br4D-5oexA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A
PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens;
Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 LYS A 193
ASP B 550
ASP B 572
 None
 0.95A 2br4D-5vniA:
undetectable		 2br4D-5vniA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcb PROBABLE SURFACE
PROTEIN

(Clostridium
perfringens) 		no annotation 3 LYS A 192
ASP A 315
ASP A 331
 None
 0.70A 2br4D-5xcbA:
undetectable		 2br4D-5xcbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS07G0580900 PROTEIN
OS02G0668100 PROTEIN

(Oryza sativa;
Oryza sativa) 		PF00348
(polyprenyl_synt)
PF00348
(polyprenyl_synt) 		3 LYS A 255
ASP C 119
ASP A 168
 None
 0.85A 2br4D-5xn6A:
undetectable		 2br4D-5xn6A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
8, MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 LYS c  54
ASP c  68
ASP c  74
 None
 0.79A 2br4D-5xtcc:
undetectable		 2br4D-5xtcc:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei) 		no annotation 3 LYS A 410
ASP A 339
ASP A 402
 None
 0.87A 2br4D-5xwqA:
undetectable		 2br4D-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 3 LYS A  51
ASP A 249
ASP A 242
 None
 1.00A 2br4D-6eksA:
undetectable		 2br4D-6eksA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL
ATP SYNTHASE GAMMA
SUBUNIT

(Trypanosoma
brucei;
Trypanosoma
brucei) 		no annotation
no annotation 		3 LYS G   8
ASP A 283
ASP A 346
 None
 0.81A 2br4D-6f5dG:
undetectable		 2br4D-6f5dG:
undetectable