SIMILAR PATTERNS OF AMINO ACIDS FOR 2BR4_C_SAMC301
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1buc | BUTYRYL-COADEHYDROGENASE (Megasphaeraelsdenii) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 6 | LEU A 24LEU A 45GLY A 85ARG A 355ARG A 31ALA A 84 | None | 1.30A | 2br4C-1bucA:undetectable | 2br4C-1bucA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f26 | NITRIC OXIDEREDUCTASE (Fusariumoxysporum) |
PF00067(p450) | 5 | LEU A 237LEU A 195SER A 179ALA A 187ALA A 184 | None | 1.00A | 2br4C-1f26A:undetectable | 2br4C-1f26A:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i1q | ANTHRANILATESYNTHASE COMPONENT I (Salmonellaenterica) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 5 | LEU A 208LEU A 197GLY A 77ARG A 207ALA A 58 | None | 1.10A | 2br4C-1i1qA:undetectable | 2br4C-1i1qA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ipf | TROPINONEREDUCTASE-II (Daturastramonium) |
PF13561(adh_short_C2) | 5 | GLY A 16ARG A 41ASP A 66SER A 68ALA A 95 | NDP A 261 (-3.4A)NDP A 261 (-3.6A)NDP A 261 (-4.1A)NDP A 261 ( 4.9A)NDP A 261 (-4.0A) | 0.98A | 2br4C-1ipfA:5.8 | 2br4C-1ipfA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itk | CATALASE-PEROXIDASE (Haloarculamarismortui) |
PF00141(peroxidase) | 5 | LEU A 511LEU A 458GLY A 538ALA A 467ALA A 471 | None | 0.92A | 2br4C-1itkA:undetectable | 2br4C-1itkA:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mxf | PTERIDINE REDUCTASE2 (Trypanosomacruzi) |
PF13561(adh_short_C2) | 5 | GLY A 18ARG A 43ASP A 70SER A 72ALA A 102 | NDP A1277 ( 3.7A)NDP A1277 (-3.7A)NDP A1277 (-3.9A)NDP A1277 (-3.5A)NDP A1277 (-3.7A) | 0.95A | 2br4C-1mxfA:4.8 | 2br4C-1mxfA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pc3 | PHOSPHATE-BINDINGPROTEIN 1 (Mycobacteriumtuberculosis) |
PF12849(PBP_like_2) | 5 | LEU A 309LEU A 30GLY A 80ALA A 72ALA A 73 | None | 0.99A | 2br4C-1pc3A:undetectable | 2br4C-1pc3A:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgz | PROTEIN(FERREDOXIN:NADP+REDUCTASE) (Nostoc sp. PCC7119) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | LEU A 189GLY A 158CYH A 98ALA A 160ALA A 82 | NoneNoneNoneFAD A 304 ( 4.0A)None | 1.14A | 2br4C-1qgzA:3.7 | 2br4C-1qgzA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t5j | HYPOTHETICAL PROTEINMJ1187 (Methanocaldococcusjannaschii) |
PF03747(ADP_ribosyl_GH) | 5 | LEU A 139GLY A 132SER A 150ALA A 167ALA A 163 | None | 1.12A | 2br4C-1t5jA:undetectable | 2br4C-1t5jA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ta9 | GLYCEROLDEHYDROGENASE (Schizosaccharomycespombe) |
PF00465(Fe-ADH) | 5 | LEU A 367CYH A 267ASP A 232ALA A 233ALA A 297 | NoneNone ZN A1502 (-2.1A)NoneNone | 1.14A | 2br4C-1ta9A:3.7 | 2br4C-1ta9A:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqy | ACTINORHODINPOLYKETIDE PUTATIVEBETA-KETOACYLSYNTHASE 2 (Streptomycescoelicolor) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY B 7ARG B 245ASP B 85ALA B 82ALA B 79 | None | 1.14A | 2br4C-1tqyB:undetectable | 2br4C-1tqyB:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqy | ACTINORHODINPOLYKETIDE PUTATIVEBETA-KETOACYLSYNTHASE 1ACTINORHODINPOLYKETIDE PUTATIVEBETA-KETOACYLSYNTHASE 2 (Streptomycescoelicolor;Streptomycescoelicolor) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | LEU B 304GLY B 393ARG B 391ASP A 141ASP B 262 | None | 1.07A | 2br4C-1tqyB:undetectable | 2br4C-1tqyB:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u2l | PEROXIDASE/CATALASEHPI (Escherichiacoli) |
PF00141(peroxidase) | 5 | LEU A 513LEU A 462GLY A 533ALA A 471ALA A 475 | None | 0.99A | 2br4C-1u2lA:undetectable | 2br4C-1u2lA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uzn | 3-OXOACYL-[ACYL-CARRIER PROTEIN]REDUCTASE (Mycobacteriumtuberculosis) |
PF13561(adh_short_C2) | 5 | GLY A 22ARG A 47ASP A 61ALA A 89ALA A 111 | NAP A1249 (-3.2A)NAP A1249 (-3.6A)NAP A1249 (-3.7A)NAP A1249 (-3.7A)NAP A1249 (-3.6A) | 1.03A | 2br4C-1uznA:5.3 | 2br4C-1uznA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vl8 | GLUCONATE5-DEHYDROGENASE (Thermotogamaritima) |
PF13561(adh_short_C2) | 5 | GLY A 16ARG A 41ASP A 67SER A 69ALA A 95 | NAP A 274 (-3.2A)NAP A 274 (-3.4A)NAP A 274 (-3.6A)NAP A 274 ( 4.7A)NAP A 274 (-3.2A) | 0.83A | 2br4C-1vl8A:4.4 | 2br4C-1vl8A:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xc6 | BETA-GALACTOSIDASE (Penicillium sp.) |
PF01301(Glyco_hydro_35)PF10435(BetaGal_dom2)PF13363(BetaGal_dom3)PF13364(BetaGal_dom4_5) | 5 | LEU A 342LEU A 340GLY A 387TYR A 329ALA A 87 | None | 1.12A | 2br4C-1xc6A:undetectable | 2br4C-1xc6A:14.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xg5 | ARPG836 (Homo sapiens) |
PF00106(adh_short) | 5 | GLY A 18ARG A 43ASP A 70SER A 72ALA A 98 | NAP A1301 (-3.5A)NAP A1301 (-3.8A)NAP A1301 (-3.8A)NAP A1301 ( 4.3A)NAP A1301 (-3.6A) | 0.94A | 2br4C-1xg5A:6.3 | 2br4C-1xg5A:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xhl | SHORT-CHAINDEHYDROGENASE/REDUCTASE FAMILY MEMBER(5L265), PUTATIVETROPINONEREDUCTASE-II (Caenorhabditiselegans) |
PF13561(adh_short_C2) | 5 | GLY A 13ARG A 38ARG A 42ASP A 66ALA A 94 | NDP A1278 (-3.1A)NDP A1278 (-3.6A)NDP A1278 (-2.8A)NDP A1278 (-3.4A)NDP A1278 (-3.9A) | 0.89A | 2br4C-1xhlA:5.3 | 2br4C-1xhlA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xkq | SHORT-CHAINREDUCTASE FAMILYMEMBER (5D234) (Caenorhabditiselegans) |
PF13561(adh_short_C2) | 5 | GLY A 13ARG A 38ARG A 42ASP A 66ALA A 94 | NDP A1281 (-2.9A)NDP A1281 (-3.8A)NDP A1281 (-2.7A)NDP A1281 (-3.6A)NDP A1281 (-3.7A) | 0.87A | 2br4C-1xkqA:5.4 | 2br4C-1xkqA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yb1 | 17-BETA-HYDROXYSTEROID DEHYDROGENASETYPE XI (Homo sapiens) |
PF00106(adh_short) | 5 | GLY A 38ASP A 88CYH A 89SER A 90ALA A 116 | CL A 402 ( 3.7A) CL A 405 ( 4.9A) CL A 405 (-4.6A)None CL A 402 ( 4.1A) | 0.91A | 2br4C-1yb1A:5.4 | 2br4C-1yb1A:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjy | R-SPECIFIC ALCOHOLDEHYDROGENASE (Lactobacillusbrevis) |
PF13561(adh_short_C2) | 5 | GLY A 13ARG A 38ASP A 62SER A 64ALA A 90 | NAI A1270 (-2.9A)NAI A1270 (-4.6A)NAI A1270 (-3.1A)NoneNAI A1270 (-3.2A) | 1.06A | 2br4C-1zjyA:6.0 | 2br4C-1zjyA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b4q | RHAMNOLIPIDSBIOSYNTHESIS3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Pseudomonasaeruginosa) |
PF13561(adh_short_C2) | 5 | GLY A 16ARG A 41ASP A 65SER A 67ALA A 93 | NAP A1901 (-3.2A)NAP A1901 (-3.6A)NAP A1901 (-3.8A)NAP A1901 (-4.0A)NAP A1901 (-3.8A) | 0.87A | 2br4C-2b4qA:4.9 | 2br4C-2b4qA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b5o | FERREDOXIN--NADPREDUCTASE (Synechococcussp. PCC 7002) |
PF00175(NAD_binding_1) | 5 | LEU A 288GLY A 261CYH A 200ALA A 263ALA A 184 | NoneNoneNoneFAD A 403 ( 4.3A)None | 1.09A | 2br4C-2b5oA:3.8 | 2br4C-2b5oA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bd0 | SEPIAPTERINREDUCTASE (Chlorobaculumtepidum) |
PF00106(adh_short) | 5 | GLY A 9ARG A 41ASP A 66SER A 68ALA A 94 | NAP A 800 (-3.2A)NAP A 800 (-3.4A)NAP A 800 (-3.6A)NAP A 800 ( 4.1A)NAP A 800 (-3.6A) | 0.91A | 2br4C-2bd0A:7.0 | 2br4C-2bd0A:24.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2br4 | CEPHALOSPORINHYDROXYLASE CMCI (Streptomycesclavuligerus) |
PF04989(CmcI) | 12 | LEU A 18LEU A 64GLY A 89TYR A 91ARG A 117ARG A 121ASP A 138CYH A 139SER A 140ASP A 160ALA A 161ALA A 163 | SAM A 301 ( 4.4A)SAM A 301 (-4.2A)SAM A 301 (-3.3A)SAM A 301 (-4.3A)SAM A 301 (-3.7A)SAM A 301 (-3.1A)SAM A 301 (-3.7A)SAM A 301 (-2.9A)None MG A 300 ( 3.6A)SAM A 301 (-3.6A)SAM A 301 ( 3.7A) | 0.51A | 2br4C-2br4A:35.7 | 2br4C-2br4A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cx9 | ACYL-COADEHYDROGENASE (Thermusthermophilus) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | LEU A 22GLY A 83TYR A 81ALA A 86ALA A 90 | None | 0.99A | 2br4C-2cx9A:undetectable | 2br4C-2cx9A:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dc5 | GLUTATHIONES-TRANSFERASE, MU 7 (Mus musculus) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | LEU A 28LEU A 87ARG A 39ASP A 16ALA A 21 | None | 1.11A | 2br4C-2dc5A:undetectable | 2br4C-2dc5A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e6m | WERNER SYNDROMEATP-DEPENDENTHELICASE HOMOLOG (Mus musculus) |
PF01612(DNA_pol_A_exo1) | 5 | LEU A 155GLY A 74CYH A 103ALA A 211ALA A 208 | None | 1.10A | 2br4C-2e6mA:undetectable | 2br4C-2e6mA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fbv | WERNER SYNDROMEHELICASE (Homo sapiens) |
PF01612(DNA_pol_A_exo1) | 5 | LEU A 161GLY A 80CYH A 109ALA A 217ALA A 214 | None | 1.14A | 2br4C-2fbvA:undetectable | 2br4C-2fbvA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fr1 | ERYTHROMYCINSYNTHASE, ERYAI (Saccharopolysporaerythraea) |
PF08659(KR) | 5 | GLY A1672ARG A1698ASP A1726ALA A1753ALA A1775 | NDP A 301 ( 4.0A)NDP A 301 (-3.9A)NDP A 301 (-3.4A)NDP A 301 ( 3.7A)NDP A 301 (-3.3A) | 0.84A | 2br4C-2fr1A:6.0 | 2br4C-2fr1A:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h1y | MALONYL COENZYMEA-ACYL CARRIERPROTEIN TRANSACYLASE (Helicobacterpylori) |
PF00698(Acyl_transf_1) | 5 | LEU A 176GLY A 168CYH A 199ALA A 167ALA A 156 | None | 1.02A | 2br4C-2h1yA:undetectable | 2br4C-2h1yA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h26 | T-CELL SURFACEGLYCOPROTEIN CD1B (Homo sapiens) |
PF07654(C1-set)PF16497(MHC_I_3) | 5 | LEU A 259GLY A 254ARG A 222ASP A 253ALA A 252 | None | 1.12A | 2br4C-2h26A:undetectable | 2br4C-2h26A:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iou | PERTACTINEXTRACELLULAR DOMAIN (Bordetellabronchiseptica) |
PF03212(Pertactin) | 6 | LEU G 231LEU G 256GLY G 245SER G 217ALA G 222ALA G 213 | None | 1.49A | 2br4C-2iouG:undetectable | 2br4C-2iouG:18.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iq1 | PROTEIN PHOSPHATASE2C KAPPA, PPM1K (Homo sapiens) |
PF00481(PP2C) | 5 | LEU A 258LEU A 269GLY A 265CYH A 138ALA A 190 | None | 1.14A | 2br4C-2iq1A:undetectable | 2br4C-2iq1A:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kqk | NIFU-LIKE PROTEIN (Escherichiacoli) |
PF01592(NifU_N) | 5 | LEU A 109GLY A 30SER A 123ALA A 116ALA A 119 | None | 1.07A | 2br4C-2kqkA:undetectable | 2br4C-2kqkA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfe | ALKALINE SERINEPROTEASE (Thermobifidafusca) |
PF00089(Trypsin) | 5 | LEU A 242LEU A 235GLY A 211SER A 134ALA A 130 | None | 1.12A | 2br4C-2pfeA:undetectable | 2br4C-2pfeA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pge | MENC (Desulfotaleapsychrophila) |
PF13378(MR_MLE_C) | 5 | LEU A 81LEU A 85GLY A 44ALA A 128ALA A 124 | None | 1.06A | 2br4C-2pgeA:undetectable | 2br4C-2pgeA:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qmo | DETHIOBIOTINSYNTHETASE (Helicobacterpylori) |
PF13500(AAA_26) | 5 | LEU A 99LEU A 138GLY A 117SER A 49ALA A 51 | None | 1.02A | 2br4C-2qmoA:undetectable | 2br4C-2qmoA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qpm | CYTOKININDEHYDROGENASE 1 (Zea mays) |
PF01565(FAD_binding_4)PF09265(Cytokin-bind) | 5 | LEU A 107GLY A 104ASP A 60ALA A 111ALA A 99 | NoneFAD A1535 (-3.3A)NoneFAD A1535 ( 3.7A)FAD A1535 ( 4.3A) | 1.05A | 2br4C-2qpmA:undetectable | 2br4C-2qpmA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r4j | AEROBICGLYCEROL-3-PHOSPHATEDEHYDROGENASE (Escherichiacoli) |
PF01266(DAO)PF16901(DAO_C) | 5 | GLY A 422ARG A 395ASP A 394ALA A 418ALA A 399 | None | 1.06A | 2br4C-2r4jA:2.7 | 2br4C-2r4jA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rek | PUTATIVE TETR-FAMILYTRANSCRIPTIONALREGULATOR (Streptomycescoelicolor) |
PF00440(TetR_N) | 5 | LEU A 74LEU A 132GLY A 102ARG A 70ALA A 99 | None | 1.07A | 2br4C-2rekA:undetectable | 2br4C-2rekA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vfv | XYLITOL OXIDASE (Streptomycescoelicolor) |
PF01565(FAD_binding_4)PF04030(ALO) | 5 | LEU A 174LEU A 90GLY A 83ALA A 113ALA A 117 | NoneNoneSFD A1418 ( 4.3A)SFD A1418 (-3.5A)SFD A1418 (-3.2A) | 0.92A | 2br4C-2vfvA:undetectable | 2br4C-2vfvA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsu | P-HYDROXYCINNAMOYLCOA HYDRATASE/LYASE (Pseudomonasfluorescens) |
PF00378(ECH_1) | 5 | LEU C 45LEU C 57TYR C 105ALA C 127ALA C 123 | None | 1.13A | 2br4C-2vsuC:undetectable | 2br4C-2vsuC:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2waw | MOBA RELATE PROTEIN (Mycobacteriumsp. DSM 3803) |
PF12804(NTP_transf_3) | 5 | LEU A 49GLY A 104ASP A 155SER A 82ALA A 13 | NoneNoneNoneCSO A 81 ( 4.5A)None | 1.12A | 2br4C-2wawA:undetectable | 2br4C-2wawA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ab7 | PUTATIVEUNCHARACTERIZEDPROTEIN TTHA0350 (Thermusthermophilus) |
PF00582(Usp) | 5 | LEU A 228LEU A 238GLY A 241ALA A 167ALA A 163 | LEU A 228 ( 0.6A)LEU A 238 ( 0.6A)GLY A 241 ( 0.0A)ALA A 167 ( 0.0A)ALA A 163 ( 0.0A) | 1.11A | 2br4C-3ab7A:2.2 | 2br4C-3ab7A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aiv | BETA-GLUCOSIDASE (Secale cereale) |
PF00232(Glyco_hydro_1) | 5 | LEU A 311SER A 339ASP A 356ALA A 357ALA A 359 | None | 1.06A | 2br4C-3aivA:undetectable | 2br4C-3aivA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cwc | PUTATIVE GLYCERATEKINASE 2 (Salmonellaenterica) |
PF02595(Gly_kinase) | 5 | LEU A 183LEU A 122GLY A 115ASP A 140ALA A 148 | None | 1.05A | 2br4C-3cwcA:undetectable | 2br4C-3cwcA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ek1 | ALDEHYDEDEHYDROGENASE (Brucellaabortus) |
PF00171(Aldedh) | 5 | LEU A 310GLY A 277ASP A 276ALA A 274ALA A 269 | None | 1.13A | 2br4C-3ek1A:3.1 | 2br4C-3ek1A:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f6m | 2-C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE (Yersinia pestis) |
PF02542(YgbB) | 5 | GLY A 18TYR A 29ASP A 38SER A 37ALA A 35 | None | 1.09A | 2br4C-3f6mA:undetectable | 2br4C-3f6mA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fs2 | 2-DEHYDRO-3-DEOXYPHOSPHOOCTONATEALDOLASE (Brucellamelitensis) |
PF00793(DAHP_synth_1) | 5 | LEU A 264LEU A 50GLY A 53ALA A 22ALA A 234 | None | 1.11A | 2br4C-3fs2A:undetectable | 2br4C-3fs2A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j3i | CAPSID PROTEIN (Penicilliumchrysogenumvirus) |
no annotation | 5 | LEU A 375GLY A 372CYH A 324SER A 323ALA A 319 | None | 1.09A | 2br4C-3j3iA:undetectable | 2br4C-3j3iA:12.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kb3 | PROTEIN PHOSPHATASE2C 16 (Arabidopsisthaliana) |
PF00481(PP2C) | 5 | LEU B 394LEU B 405GLY B 401CYH B 254ALA B 329 | None | 1.13A | 2br4C-3kb3B:undetectable | 2br4C-3kb3B:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kgk | ARSENICAL RESISTANCEOPERON TRANS-ACTINGREPRESSOR ARSD (Escherichiacoli) |
PF06953(ArsD) | 5 | LEU A 78GLY A 99ARG A 96ALA A 95ALA A 92 | None | 0.89A | 2br4C-3kgkA:undetectable | 2br4C-3kgkA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l77 | SHORT-CHAIN ALCOHOLDEHYDROGENASE (Thermococcussibiricus) |
PF00106(adh_short) | 5 | GLY A 8ARG A 33ASP A 59SER A 61ALA A 87 | NJP A 501 (-3.3A)NJP A 501 (-3.5A)NJP A 501 (-3.6A)PG4 A 245 ( 4.1A)NJP A 501 (-3.5A) | 0.85A | 2br4C-3l77A:6.0 | 2br4C-3l77A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lf2 | SHORT CHAINOXIDOREDUCTASEQ9HYA2 (Pseudomonasaeruginosa) |
PF13561(adh_short_C2) | 5 | GLY A 15ARG A 40ARG A 44ASP A 67ALA A 95 | NDP A 301 (-3.2A)NDP A 301 (-3.7A)NDP A 301 (-3.9A)NDP A 301 (-3.6A)NDP A 301 (-3.6A) | 0.88A | 2br4C-3lf2A:5.8 | 2br4C-3lf2A:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lsc | TRIAZINE HYDROLASE (Paenarthrobacteraurescens) |
PF01979(Amidohydro_1) | 5 | LEU A 335LEU A 339GLY A 321ALA A 294ALA A 273 | None | 0.99A | 2br4C-3lscA:undetectable | 2br4C-3lscA:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pmo | UDP-3-O-[3-HYDROXYMYRISTOYL] GLUCOSAMINEN-ACYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00132(Hexapep)PF04613(LpxD) | 5 | LEU A 92GLY A 10TYR A 7ALA A 13ALA A 18 | None | 1.10A | 2br4C-3pmoA:undetectable | 2br4C-3pmoA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3v | PHOSPHOGLYCERATEKINASE (Campylobacterjejuni) |
PF00162(PGK) | 5 | LEU A 12GLY A 172TYR A 48ASP A 180ALA A 171 | None | 1.12A | 2br4C-3q3vA:undetectable | 2br4C-3q3vA:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rxz | POLYSACCHARIDEDEACETYLASE (Mycolicibacteriumsmegmatis) |
PF01522(Polysacc_deac_1) | 6 | LEU A 65LEU A 68GLY A 98ARG A 96ALA A 95ALA A 134 | None | 1.46A | 2br4C-3rxzA:undetectable | 2br4C-3rxzA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uhj | PROBABLE GLYCEROLDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00465(Fe-ADH) | 5 | LEU A 329CYH A 230ASP A 193ALA A 194ALA A 260 | NoneNone ZN A 388 (-2.2A)NoneNone | 1.10A | 2br4C-3uhjA:undetectable | 2br4C-3uhjA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ut2 | CATALASE-PEROXIDASE2 (Magnaportheoryzae) |
PF00141(peroxidase) | 5 | LEU A 564LEU A 511GLY A 590ALA A 520ALA A 524 | None | 0.98A | 2br4C-3ut2A:undetectable | 2br4C-3ut2A:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v9r | UNCHARACTERIZEDPROTEIN YOL086W-AUNCHARACTERIZEDPROTEIN YDL160C-A (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF15630(CENP-S)PF09415(CENP-X) | 5 | LEU A 14LEU B 2SER B 45ASP B 35ALA B 41 | None | 1.09A | 2br4C-3v9rA:undetectable | 2br4C-3v9rA:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w5v | FERREDOXIN (Zea mays) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | LEU A 200GLY A 173CYH A 114ALA A 175ALA A 98 | NoneNoneNoneFAD A 401 ( 4.0A)None | 1.11A | 2br4C-3w5vA:3.3 | 2br4C-3w5vA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxo | CATALASE-PEROXIDASE (Synechococcuselongatus) |
PF00141(peroxidase) | 5 | LEU A 510LEU A 457GLY A 529ALA A 466ALA A 470 | None | 1.04A | 2br4C-3wxoA:undetectable | 2br4C-3wxoA:16.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x0u | UNCHARACTERIZEDPROTEIN (Vibrioparahaemolyticus) |
PF03945(Endotoxin_N) | 5 | TYR A 220CYH A 239ASP A 218ALA A 215ALA A 212 | None | 1.15A | 2br4C-3x0uA:undetectable | 2br4C-3x0uA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4akk | NITRATE REGULATORYPROTEIN (Klebsiellaoxytoca) |
PF03861(ANTAR)PF08376(NIT) | 5 | GLY A 328ARG A 199ARG A 375SER A 133ALA A 331 | None | 1.08A | 2br4C-4akkA:undetectable | 2br4C-4akkA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4azc | BETA-N-ACETYLHEXOSAMINIDASE (Streptococcuspneumoniae) |
PF00728(Glyco_hydro_20) | 5 | GLY A 672TYR A 706ASP A 744ALA A 745ALA A 749 | None | 1.02A | 2br4C-4azcA:undetectable | 2br4C-4azcA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1o | BETA-XYLOSIDASE (Parageobacillusthermoglucosidasius) |
PF03512(Glyco_hydro_52) | 5 | LEU A 230LEU A 110GLY A 69TYR A 67ALA A 181 | None | 1.04A | 2br4C-4c1oA:undetectable | 2br4C-4c1oA:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c51 | CATALASE-PEROXIDASE (Mycobacteriumtuberculosis) |
PF00141(peroxidase) | 5 | LEU A 521LEU A 467GLY A 548ALA A 476ALA A 480 | None | 0.88A | 2br4C-4c51A:undetectable | 2br4C-4c51A:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4da1 | PROTEIN PHOSPHATASE1K, MITOCHONDRIAL (Homo sapiens) |
PF00481(PP2C) | 5 | LEU A 258LEU A 269GLY A 265CYH A 138ALA A 190 | None | 1.14A | 2br4C-4da1A:undetectable | 2br4C-4da1A:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4duu | PLASMINOGEN (Homo sapiens) |
PF00024(PAN_1)PF00051(Kringle)PF00089(Trypsin) | 6 | LEU A 745GLY A 742TYR A 774CYH A 604ALA A 601ALA A 602 | None | 1.39A | 2br4C-4duuA:undetectable | 2br4C-4duuA:13.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fqg | TRANSCRIPTIONELONGATION REGULATOR1 (Homo sapiens) |
PF01846(FF) | 5 | LEU A 54LEU A 16GLY A 43ARG A 5ALA A 8 | None | 1.06A | 2br4C-4fqgA:undetectable | 2br4C-4fqgA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hdj | OUTER MEMBRANEPROTEIN ASSEMBLYFACTOR BAMB (Pseudomonasaeruginosa) |
PF13360(PQQ_2) | 5 | LEU A 188GLY A 237ARG A 357SER A 271ALA A 254 | None | 1.14A | 2br4C-4hdjA:undetectable | 2br4C-4hdjA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hst | GLUTARYL-7-AMINOCEPHALOSPORANIC ACIDACYLASE BETA CHAIN (Pseudomonas) |
PF01804(Penicil_amidase) | 5 | ASP B 509CYH B 510ASP B 288ALA B 287ALA B 283 | None | 1.02A | 2br4C-4hstB:undetectable | 2br4C-4hstB:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hyq | PHOSPHOLIPASE A1 (Streptomycesalbidoflavus) |
PF13472(Lipase_GDSL_2) | 5 | GLY A 86ASP A 10SER A 11ASP A 89ALA A 88 | NoneNone1PE A 301 ( 4.3A)None1PE A 301 (-4.2A) | 1.10A | 2br4C-4hyqA:2.1 | 2br4C-4hyqA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4imp | POLYKETIDE SYNTHASEEXTENDER MODULES 3-4 (Saccharopolysporaspinosa) |
PF08659(KR) | 5 | GLY A 288ARG A 314ASP A 342ALA A 365ALA A 387 | NDP A1501 (-3.6A)NDP A1501 (-3.6A)NDP A1501 (-3.2A)NDP A1501 (-3.6A)NDP A1501 (-3.4A) | 0.89A | 2br4C-4impA:undetectable | 2br4C-4impA:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j1s | POLYKETIDE SYNTHASEPKSJ (Bacillussubtilis) |
PF08659(KR) | 5 | GLY A 188ARG A 215ASP A 242SER A 244ALA A 270 | None | 0.71A | 2br4C-4j1sA:4.8 | 2br4C-4j1sA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j1s | POLYKETIDE SYNTHASEPKSJ (Bacillussubtilis) |
PF08659(KR) | 5 | LEU A 193GLY A 188ASP A 242SER A 244ALA A 270 | None | 1.01A | 2br4C-4j1sA:4.8 | 2br4C-4j1sA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j2u | ENOYL-COA HYDRATASE (Rhodobactersphaeroides) |
PF16113(ECH_2) | 5 | LEU A 162GLY A 170ASP A 173ALA A 174ALA A 180 | None | 1.12A | 2br4C-4j2uA:undetectable | 2br4C-4j2uA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l4x | AMPHI (Streptomycesnodosus) |
PF08659(KR) | 5 | GLY A 284ARG A 310ASP A 338ALA A 366ALA A 388 | NDP A 601 (-3.3A)NDP A 601 (-3.1A)NDP A 601 (-3.4A)NDP A 601 (-4.1A)NDP A 601 ( 3.9A) | 0.90A | 2br4C-4l4xA:2.3 | 2br4C-4l4xA:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r5z | PUTATIVEPHENYLALANINEAMINOTRANSFERASE (Mycobacteriumtuberculosis) |
PF00155(Aminotran_1_2) | 5 | LEU A 70LEU A 200GLY A 231ASP A 240ALA A 229 | None | 1.12A | 2br4C-4r5zA:3.2 | 2br4C-4r5zA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rf3 | NADPH DEPENDENTR-SPECIFIC ALCOHOLDEHYDROGENASE (Lactobacilluskefiri) |
PF13561(adh_short_C2) | 5 | GLY A 14ARG A 39ASP A 63SER A 65ALA A 91 | None | 0.98A | 2br4C-4rf3A:5.8 | 2br4C-4rf3A:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w91 | AMINOTRANSFERASE (Brucella suis) |
PF00266(Aminotran_5) | 5 | TYR A 111ASP A 208SER A 210ALA A 105ALA A 102 | NoneLLP A 234 ( 2.5A)LLP A 234 ( 3.3A)NoneLLP A 234 ( 3.8A) | 1.10A | 2br4C-4w91A:3.8 | 2br4C-4w91A:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z1o | PHOSPHORIBOSYLTRANSFERASE (Sulfolobussolfataricus) |
PF00156(Pribosyltran) | 5 | LEU A 90LEU A 47SER A 128ALA A 121ALA A 96 | NoneNoneNoneNonePRP A 201 ( 4.6A) | 0.96A | 2br4C-4z1oA:3.9 | 2br4C-4z1oA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c3m | PUTATIVE6-PHOSPHO-BETA-GLUCOSIDASE (Geobacillusstearothermophilus) |
PF02056(Glyco_hydro_4)PF11975(Glyco_hydro_4C) | 5 | LEU A 423LEU A 427GLY A 398TYR A 400ALA A 392 | None | 1.15A | 2br4C-5c3mA:undetectable | 2br4C-5c3mA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d2e | MLNE (Bacillusvelezensis) |
PF08659(KR) | 5 | GLY A 280ARG A 306ASP A 333SER A 335ALA A 361 | NAP A 601 (-3.5A)NAP A 601 (-3.7A)NAP A 601 (-3.6A)GOL A 602 (-3.6A)NAP A 601 (-3.5A) | 0.73A | 2br4C-5d2eA:2.6 | 2br4C-5d2eA:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d3m | ENERGY-COUPLINGFACTOR TRANSPORTERATP-BINDING PROTEINECFA1 (Lactobacillusdelbrueckii) |
PF00005(ABC_tran) | 5 | LEU A 183LEU A 167ARG A 187ASP A 266ALA A 207 | None | 1.12A | 2br4C-5d3mA:undetectable | 2br4C-5d3mA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5feu | NOROXOMARITIDINE/NORCRAUGSODINEREDUCTASE (Narcissuspseudonarcissus) |
PF13561(adh_short_C2) | 5 | GLY A 32ARG A 57ASP A 82SER A 84ALA A 111 | NAP A 301 (-3.3A)NAP A 301 (-3.5A)NAP A 301 (-3.7A)NAP A 301 ( 4.6A)NAP A 301 ( 3.8A) | 0.75A | 2br4C-5feuA:5.8 | 2br4C-5feuA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ff9 | NOROXOMARITIDINE/NORCRAUGSODINEREDUCTASE (Narcissuspseudonarcissus) |
PF13561(adh_short_C2) | 5 | GLY A 32ARG A 57ASP A 82SER A 84ALA A 111 | NAP A 301 (-3.3A)NAP A 301 (-3.9A)NAP A 301 (-3.6A)NAP A 301 ( 4.2A)NAP A 301 ( 3.8A) | 0.78A | 2br4C-5ff9A:2.0 | 2br4C-5ff9A:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gwo | PROBABLE PROTEINPHOSPHATASE 2C 50 (Oryza sativa) |
PF00481(PP2C) | 5 | LEU A 268LEU A 279GLY A 275CYH A 129ALA A 203 | None | 1.08A | 2br4C-5gwoA:undetectable | 2br4C-5gwoA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5irm | UNCHARACTERIZEDPROTEIN (Oryctolaguscuniculus) |
PF05729(NACHT)PF13516(LRR_6) | 5 | LEU A 968LEU A 983GLY A 958ALA A 928ALA A 926 | None | 1.10A | 2br4C-5irmA:undetectable | 2br4C-5irmA:13.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kqi | CATALASE-PEROXIDASE (Burkholderiapseudomallei) |
PF00141(peroxidase) | 5 | LEU A 528LEU A 475GLY A 555ALA A 484ALA A 488 | None | 0.97A | 2br4C-5kqiA:undetectable | 2br4C-5kqiA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mpd | 26S PROTEASOMEREGULATORY SUBUNITRPN2 (Saccharomycescerevisiae) |
PF01851(PC_rep)PF13646(HEAT_2) | 5 | LEU N 591GLY N 620ASP N 647ALA N 622ALA N 656 | None | 1.10A | 2br4C-5mpdN:undetectable | 2br4C-5mpdN:12.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t2u | OXIDOREDUCTASE,SHORT CHAINDEHYDROGENASE/REDUCTASE FAMILY PROTEIN (Mycolicibacteriumsmegmatis) |
PF13561(adh_short_C2) | 5 | GLY A 12ARG A 37ARG A 41ASP A 59ALA A 83 | NAP A 301 (-3.3A)NAP A 301 (-3.5A)NAP A 301 (-3.0A)NAP A 301 (-3.8A)NAP A 301 ( 3.7A) | 0.72A | 2br4C-5t2uA:5.4 | 2br4C-5t2uA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u7x | NOD FACTOR BINDINGLECTIN-NUCLEOTIDEPHOSPHOHYDROLASE (Vignaunguiculata) |
PF01150(GDA1_CD39) | 5 | GLY F 210TYR F 206ARG F 208SER F 241ALA F 162 | NoneNoneNoneNonePO4 F 502 (-3.7A) | 1.06A | 2br4C-5u7xF:undetectable | 2br4C-5u7xF:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5upy | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Listeriamonocytogenes) |
PF00478(IMPDH) | 5 | GLY A 301ARG A 311ASP A 326CYH A 327ASP A 341 | NoneNoneNoneNoneIMP A 500 (-2.6A) | 1.05A | 2br4C-5upyA:undetectable | 2br4C-5upyA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uuw | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH) | 5 | GLY A 301ARG A 311ASP A 326CYH A 327ASP A 341 | NoneNoneNoneNoneIMP A 501 (-2.4A) | 1.05A | 2br4C-5uuwA:undetectable | 2br4C-5uuwA:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xww | AMPHB (Streptomycesnodosus) |
no annotation | 5 | GLY A 225ARG A 251ARG A 252ALA A 306ALA A 329 | NAP A 501 (-3.6A)NAP A 501 (-3.6A)NAP A 501 (-4.0A)NAP A 501 (-3.5A)NAP A 501 ( 3.7A) | 1.05A | 2br4C-5xwwA:6.0 | 2br4C-5xwwA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xww | AMPHB (Streptomycesnodosus) |
no annotation | 5 | GLY A 225ARG A 251ASP A 279ALA A 306ALA A 329 | NAP A 501 (-3.6A)NAP A 501 (-3.6A)NAP A 501 (-3.4A)NAP A 501 (-3.5A)NAP A 501 ( 3.7A) | 0.80A | 2br4C-5xwwA:6.0 | 2br4C-5xwwA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b9u | DNA GYRASE, SUBUNITB:SHORT-CHAINDEHYDROGENASE/REDUCTASESDR:GLUCOSE/RIBITOLDEHYDROGENASE (Brucellaabortus) |
no annotation | 6 | LEU A 194GLY A 13ARG A 38ASP A 60SER A 62ALA A 88 | NAI A 301 (-3.3A)NAI A 301 (-3.1A)NAI A 301 (-3.4A)NAI A 301 (-3.4A)NAI A 301 ( 4.4A)NAI A 301 (-3.7A) | 1.12A | 2br4C-6b9uA:5.1 | 2br4C-6b9uA:23.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2br4 | CEPHALOSPORINHYDROXYLASE CMCI (Streptomycesclavuligerus) |
PF04989(CmcI) | 4 | LYS A 65GLU A 87SER A 95ASP A 116 | SAM A 301 (-2.6A)SAM A 301 (-3.0A)SAM A 301 (-3.0A)SAM A 301 (-3.0A) | 0.19A | 2br4C-2br4A:35.7 | 2br4C-2br4A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e53 | FATTY-ACID-COALIGASE FADD28 (Mycobacteriumtuberculosis) |
PF00501(AMP-binding) | 4 | LYS A 454GLU A 348SER A 375ASP A 351 | None | 1.39A | 2br4C-3e53A:0.0 | 2br4C-3e53A:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ssm | METHYLTRANSFERASE (Micromonosporagriseorubida) |
no annotation | 4 | LYS A 175GLU A 202SER A 217ASP A 234 | SAH A 601 (-3.1A)SAH A 601 (-3.4A)SAH A 601 (-3.2A)SAH A 601 (-2.8A) | 0.76A | 2br4C-3ssmA:12.5 | 2br4C-3ssmA:23.08 |