SIMILAR PATTERNS OF AMINO ACIDS FOR 2BR4_A_SAMA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09251
(PhageP22-tail) 		3 LYS A 241
ASP A 395
ASP A 444
 None
 1.02A 2br4A-1clwA:
undetectable		 2br4A-1clwA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqs PROTEIN
(3-DEHYDROQUINATE
SYNTHASE)

(Aspergillus
nidulans) 		PF01761
(DHQ_synthase) 		3 LYS A 341
ASP A 156
ASP A 119
 None
None
NAD  A 400 (-3.1A)
 1.11A 2br4A-1dqsA:
3.2		 2br4A-1dqsA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR

(Homo sapiens) 		PF00439
(Bromodomain) 		3 LYS A1454
ASP A1549
ASP A1571
 None
 0.97A 2br4A-1eqfA:
undetectable		 2br4A-1eqfA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 LYS A1023
ASP A 919
ASP A 924
 None
 1.08A 2br4A-1f4hA:
2.1		 2br4A-1f4hA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTS, IRON-SULFUR
PROTEIN OF CARBON
MONOXIDE
DEHYDROGENASE
CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava;
Hydrogenophaga
pseudoflava) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 LYS A   3
ASP B 128
ASP B  50
 None
 1.03A 2br4A-1ffvA:
undetectable		 2br4A-1ffvA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		3 LYS A 341
ASP A 174
ASP A 443
 None
 0.96A 2br4A-1ileA:
undetectable		 2br4A-1ileA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 LYS A 337
ASP A 322
ASP A 302
 None
 0.98A 2br4A-1m53A:
undetectable		 2br4A-1m53A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 LYS A  13
ASP A 344
ASP A 306
 None
 1.05A 2br4A-1mroA:
undetectable		 2br4A-1mroA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oc2 DTDP-GLUCOSE
4,6-DEHYDRATASE

(Streptococcus
suis) 		PF16363
(GDP_Man_Dehyd) 		3 LYS A 333
ASP A 279
ASP A 276
 None
 0.79A 2br4A-1oc2A:
4.8		 2br4A-1oc2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		3 LYS A  11
ASP A 199
ASP A 300
 None
 0.81A 2br4A-1ofuA:
3.2		 2br4A-1ofuA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		3 LYS A 283
ASP A 252
ASP A 349
 None
 1.17A 2br4A-1olpA:
undetectable		 2br4A-1olpA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 LYS A 344
ASP A  25
ASP A  69
 None
 1.08A 2br4A-1ykwA:
undetectable		 2br4A-1ykwA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))

(Streptococcus
pyogenes) 		PF00390
(malic)
PF03949
(Malic_M) 		3 LYS A 206
ASP A 162
ASP A 138
 None
None
MG  A 801 (-2.6A)
 0.79A 2br4A-2a9fA:
4.1		 2br4A-2a9fA:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		3 LYS A  65
ASP A 116
ASP A 138
 SAM  A 301 (-2.6A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.7A)
 0.04A 2br4A-2br4A:
38.4		 2br4A-2br4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		3 LYS A 293
ASP A 411
ASP A 485
 None
 1.11A 2br4A-2c3oA:
2.5		 2br4A-2c3oA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyg BETA-1, 3-GLUCANANSE

(Musa acuminata) 		PF00332
(Glyco_hydro_17) 		3 LYS A 317
ASP A  62
ASP A  86
 None
 1.17A 2br4A-2cygA:
undetectable		 2br4A-2cygA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef0 ORNITHINE
CARBAMOYLTRANSFERASE

(Thermus
thermophilus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 LYS A  34
ASP A 141
ASP A 220
 None
 0.96A 2br4A-2ef0A:
3.5		 2br4A-2ef0A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcw ALPHA-2-MACROGLOBULI
N
RECEPTOR-ASSOCIATED
PROTEIN
LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens;
Homo sapiens) 		PF06401
(Alpha-2-MRAP_C)
PF00057
(Ldl_recept_a) 		3 LYS A 289
ASP B 118
ASP B  97
 None
CA  B3001 (-3.3A)
None
 1.06A 2br4A-2fcwA:
undetectable		 2br4A-2fcwA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		3 LYS A 921
ASP A  56
ASP A 243
 None
 0.98A 2br4A-2fgeA:
undetectable		 2br4A-2fgeA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 LYS X 545
ASP X 537
ASP X 535
 None
 1.12A 2br4A-2iv2X:
2.5		 2br4A-2iv2X:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 LYS A 352
ASP A 412
ASP A 386
 None
 0.84A 2br4A-2ji9A:
3.6		 2br4A-2ji9A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lg1 A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		PF00169
(PH) 		3 LYS A  56
ASP A 179
ASP A 177
 None
 0.95A 2br4A-2lg1A:
undetectable		 2br4A-2lg1A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qki COMPLEMENT C3

(Homo sapiens) 		PF01759
(NTR)
PF07677
(A2M_recep) 		3 LYS C1335
ASP C1477
ASP C1535
 None
 0.98A 2br4A-2qkiC:
undetectable		 2br4A-2qkiC:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn8 RETICULON-4-INTERACT
ING PROTEIN 1

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		3 LYS A 381
ASP A 239
ASP A 254
 None
 1.08A 2br4A-2vn8A:
6.4		 2br4A-2vn8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		3 LYS A 468
ASP A 447
ASP A 444
 None
 1.03A 2br4A-2xu0A:
undetectable		 2br4A-2xu0A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT ALPHA
NITRILE HYDRATASE
SUBUNIT BETA

(Rhodococcus
erythropolis;
Rhodococcus
erythropolis) 		PF02979
(NHase_alpha)
PF02211
(NHase_beta) 		3 LYS A 115
ASP B  53
ASP B 165
 CSO  A 114 ( 3.7A)
None
None
 1.01A 2br4A-2zpbA:
undetectable		 2br4A-2zpbA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		3 LYS A  11
ASP A 312
ASP A 300
 None
 0.86A 2br4A-3abbA:
undetectable		 2br4A-3abbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alf CHITINASE, CLASS V

(Nicotiana
tabacum) 		PF00704
(Glyco_hydro_18) 		3 LYS A 311
ASP A 184
ASP A 263
 None
EDO  A 359 (-4.5A)
None
 0.93A 2br4A-3alfA:
undetectable		 2br4A-3alfA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		3 LYS A 309
ASP A 185
ASP A 261
 None
 0.88A 2br4A-3aquA:
undetectable		 2br4A-3aquA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Rattus
norvegicus) 		PF06325
(PrmA) 		3 LYS A 310
ASP A 300
ASP A 345
 None
 1.06A 2br4A-3b3jA:
5.2		 2br4A-3b3jA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkx SAM-DEPENDENT
METHYLTRANSFERASE

(Lactobacillus
paracasei) 		PF13649
(Methyltransf_25) 		3 LYS A   1
ASP A 220
ASP A 225
 None
 1.09A 2br4A-3bkxA:
6.7		 2br4A-3bkxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdj DEGV FAMILY PROTEIN

([Eubacterium]
eligens) 		PF02645
(DegV) 		3 LYS A  12
ASP A  40
ASP A  46
 None
 0.84A 2br4A-3fdjA:
2.3		 2br4A-3fdjA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fho ATP-DEPENDENT RNA
HELICASE DBP5

(Schizosaccharomyces
pombe) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 LYS A 389
ASP A 264
ASP A 261
 None
 1.04A 2br4A-3fhoA:
3.4		 2br4A-3fhoA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iac GLUCURONATE
ISOMERASE

(Salmonella
enterica) 		PF02614
(UxaC) 		3 LYS A 192
ASP A 317
ASP A  58
 None
 1.15A 2br4A-3iacA:
undetectable		 2br4A-3iacA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib6 UNCHARACTERIZED
PROTEIN

(Listeria
monocytogenes) 		PF13419
(HAD_2) 		3 LYS A  96
ASP A  22
ASP A  27
 None
 0.92A 2br4A-3ib6A:
undetectable		 2br4A-3ib6A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imh GALACTOSE-1-EPIMERAS
E

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		3 LYS A  14
ASP A 129
ASP A 131
 None
 1.01A 2br4A-3imhA:
undetectable		 2br4A-3imhA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		no annotation 3 LYS K 469
ASP K 391
ASP K 385
 None
 0.85A 2br4A-3jblK:
undetectable		 2br4A-3jblK:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moz MYO-INOSITOL
HEXAPHOSPHATE
PHOSPHOHYDROLASE

(Selenomonas
ruminantium) 		PF14566
(PTPlike_phytase) 		3 LYS A 312
ASP A 153
ASP A  59
 5IP  A 401 (-3.0A)
5IP  A 401 ( 4.9A)
None
 1.13A 2br4A-3mozA:
undetectable		 2br4A-3mozA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		3 LYS A  84
ASP A 266
ASP A 203
 None
 1.13A 2br4A-3mwgA:
undetectable		 2br4A-3mwgA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 3 LYS B 134
ASP B 238
ASP B 248
 None
 1.16A 2br4A-3n3bB:
undetectable		 2br4A-3n3bB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE

(Enterovirus A) 		PF00680
(RdRP_1) 		3 LYS A 172
ASP A 233
ASP A 359
 BUP  A 464 ( 4.9A)
None
None
 1.17A 2br4A-3n6nA:
undetectable		 2br4A-3n6nA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocd SOXA

(Starkeya
novella) 		no annotation 3 LYS A 274
ASP A 208
ASP A 203
 HEC  A 401 (-3.4A)
None
None
 1.11A 2br4A-3ocdA:
undetectable		 2br4A-3ocdA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB

(Campylobacter
jejuni) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		3 LYS A  65
ASP A 295
ASP A 289
 ADP  A 336 (-2.7A)
None
None
 1.02A 2br4A-3pfiA:
undetectable		 2br4A-3pfiA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A 105
ASP A 204
ASP A 241
 EDO  A 417 (-3.5A)
None
None
 1.10A 2br4A-3qfvA:
undetectable		 2br4A-3qfvA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qil CLATHRIN HEAVY CHAIN
1

(Bos taurus) 		PF00637
(Clathrin) 		3 LYS A1522
ASP A1546
ASP A1575
 None
 0.93A 2br4A-3qilA:
undetectable		 2br4A-3qilA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		3 LYS A1159
ASP A1058
ASP A 800
 None
 1.15A 2br4A-3s5kA:
undetectable		 2br4A-3s5kA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssm METHYLTRANSFERASE

(Micromonospora
griseorubida) 		no annotation 3 LYS A 175
ASP A 234
ASP A 252
 SAH  A 601 (-3.1A)
SAH  A 601 (-2.8A)
SAH  A 601 (-3.6A)
 0.70A 2br4A-3ssmA:
12.4		 2br4A-3ssmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stb SINGLE DOMAIN
ANTIBODY VHH
RNA-EDITING COMPLEX
PROTEIN MP42

(Lama glama;
Trypanosoma
brucei) 		PF07686
(V-set)
no annotation 		3 LYS A   4
ASP C 327
ASP C 331
 None
 1.13A 2br4A-3stbA:
undetectable		 2br4A-3stbA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7c CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		3 LYS A 119
ASP A  76
ASP A  38
 None
NAD  A 279 (-3.2A)
NAD  A 279 (-2.8A)
 1.06A 2br4A-3t7cA:
5.3		 2br4A-3t7cA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		3 LYS A 241
ASP A 464
ASP A 478
 None
 0.96A 2br4A-3tsyA:
2.2		 2br4A-3tsyA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A
ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B

(Bacillus
subtilis;
Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C)
PF12705
(PDDEXK_1) 		3 LYS B 161
ASP B 626
ASP A  58
 None
 1.14A 2br4A-3u44B:
2.4		 2br4A-3u44B:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uow GMP SYNTHETASE

(Plasmodium
falciparum) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		3 LYS A   6
ASP A 236
ASP A 413
 None
 1.15A 2br4A-3uowA:
2.5		 2br4A-3uowA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		3 LYS A 206
ASP A 313
ASP A 369
 None
 0.90A 2br4A-3wpeA:
undetectable		 2br4A-3wpeA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt0 CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		3 LYS A  17
ASP A 210
ASP A 237
 ATP  A 400 (-3.0A)
None
None
 0.77A 2br4A-3wt0A:
undetectable		 2br4A-3wt0A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 LYS B2307
ASP B2377
ASP B2608
 None
 1.10A 2br4A-4bedB:
undetectable		 2br4A-4bedB:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bum VOLTAGE-DEPENDENT
ANION CHANNEL 2

(Danio rerio) 		PF01459
(Porin_3) 		3 LYS X  42
ASP X 100
ASP X 128
 None
 1.17A 2br4A-4bumX:
undetectable		 2br4A-4bumX:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bum VOLTAGE-DEPENDENT
ANION CHANNEL 2

(Danio rerio) 		PF01459
(Porin_3) 		3 LYS X 256
ASP X  16
ASP X   9
 None
 1.02A 2br4A-4bumX:
undetectable		 2br4A-4bumX:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		3 LYS V1338
ASP V1114
ASP V1033
 None
 1.05A 2br4A-4bxsV:
undetectable		 2br4A-4bxsV:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2t DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		3 LYS A 562
ASP A 550
ASP A 527
 None
 0.70A 2br4A-4c2tA:
undetectable		 2br4A-4c2tA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		3 LYS A 593
ASP A 321
ASP A 359
 None
 1.07A 2br4A-4dxbA:
undetectable		 2br4A-4dxbA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4f THREONINE SYNTHASE

(Brucella
melitensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		3 LYS A 112
ASP A 309
ASP A 282
 PLP  A 501 (-1.7A)
None
None
 1.13A 2br4A-4f4fA:
2.3		 2br4A-4f4fA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l08 HYDROLASE,
ISOCHORISMATASE
FAMILY

(Pseudomonas
putida) 		no annotation 3 LYS B   4
ASP B 192
ASP B 198
 None
 1.10A 2br4A-4l08B:
2.2		 2br4A-4l08B:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb5 CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18)
PF16403
(DUF5011) 		3 LYS A 171
ASP A 376
ASP A 385
 None
 0.99A 2br4A-4mb5A:
undetectable		 2br4A-4mb5A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8c THERMOSTABLE NPPASE

(Geobacillus
stearothermophilus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 LYS A  56
ASP A  12
ASP A 148
 None
 1.05A 2br4A-4o8cA:
3.6		 2br4A-4o8cA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN

(Legionella
pneumophila) 		PF13855
(LRR_8) 		3 LYS A  92
ASP A 189
ASP A 237
 None
 1.00A 2br4A-4q62A:
undetectable		 2br4A-4q62A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnh MOTILITY REGULATOR

(Pseudomonas
aeruginosa) 		PF00563
(EAL)
PF00990
(GGDEF) 		3 LYS A1244
ASP A1310
ASP A1333
 None
MG  A1501 ( 2.6A)
None
 0.95A 2br4A-4rnhA:
undetectable		 2br4A-4rnhA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uri CHITINASE-RELATED
AGGLUTININ

(Robinia
pseudoacacia) 		PF00704
(Glyco_hydro_18) 		3 LYS A 302
ASP A 186
ASP A 191
 None
 1.16A 2br4A-4uriA:
undetectable		 2br4A-4uriA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3d HB3VAR03 CIDRA
DOMAIN
ENDOTHELIAL PROTEIN
C RECEPTOR

(Plasmodium
falciparum;
Homo sapiens) 		PF03011
(PFEMP)
PF16497
(MHC_I_3) 		3 LYS A 661
ASP A 576
ASP B  21
 None
 1.14A 2br4A-4v3dA:
undetectable		 2br4A-4v3dA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y2w ALANINE RACEMASE 1

(Caldanaerobacter
subterraneus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 LYS A 241
ASP A 175
ASP A 178
 None
 1.11A 2br4A-4y2wA:
undetectable		 2br4A-4y2wA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aey PLASMID SEGREGATION
PROTEIN PARM

(Escherichia
coli) 		PF06406
(StbA) 		3 LYS A  13
ASP A 177
ASP A 194
 ANP  A 500 (-2.3A)
None
None
 1.09A 2br4A-5aeyA:
undetectable		 2br4A-5aeyA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		3 LYS A   1
ASP A 777
ASP A 782
 None
 1.07A 2br4A-5azaA:
undetectable		 2br4A-5azaA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		3 LYS A 180
ASP A 169
ASP A  97
 None
 1.16A 2br4A-5e8lA:
undetectable		 2br4A-5e8lA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftx SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 3 LYS A 868
ASP A 757
ASP A 728
 None
 0.96A 2br4A-5ftxA:
undetectable		 2br4A-5ftxA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3

(Rattus
norvegicus) 		PF12796
(Ank_2)
PF16511
(FERM_f0) 		3 LYS A  36
ASP A 210
ASP A 239
 EDO  A1377 (-2.3A)
None
None
 1.02A 2br4A-5g4xA:
undetectable		 2br4A-5g4xA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grs STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		no annotation
no annotation 		3 LYS I 992
ASP A 597
ASP A 616
 None
 1.14A 2br4A-5grsI:
undetectable		 2br4A-5grsI:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		3 LYS A 259
ASP A 956
ASP A 958
 None
 1.10A 2br4A-5ijlA:
undetectable		 2br4A-5ijlA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jdp VOLTAGE-DEPENDENT
ANION-SELECTIVE
CHANNEL PROTEIN 1

(Homo sapiens) 		PF01459
(Porin_3) 		3 LYS A 109
ASP A 128
ASP A   9
 None
 1.17A 2br4A-5jdpA:
undetectable		 2br4A-5jdpA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 LYS A 781
ASP A 704
ASP A 756
 None
MG  A 802 (-2.5A)
None
 1.09A 2br4A-5jp0A:
undetectable		 2br4A-5jp0A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis) 		PF00291
(PALP) 		3 LYS B  41
ASP B 242
ASP B 245
 None
 1.16A 2br4A-5kzmB:
undetectable		 2br4A-5kzmB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN6

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		3 LYS Q  90
ASP Q  34
ASP Q  32
 None
 1.13A 2br4A-5mpdQ:
undetectable		 2br4A-5mpdQ:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		3 LYS A  46
ASP A 495
ASP A 506
 None
 0.98A 2br4A-5mq6A:
undetectable		 2br4A-5mq6A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		3 LYS A 590
ASP A 717
ASP A 772
 None
 0.74A 2br4A-5n6uA:
undetectable		 2br4A-5n6uA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nms 25.3 KDA HEAT SHOCK
PROTEIN,
CHLOROPLASTIC
25.3 KDA HEAT SHOCK
PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00011
(HSP20)
PF00011
(HSP20) 		3 LYS B  83
ASP A 100
ASP B 131
 None
 1.14A 2br4A-5nmsB:
undetectable		 2br4A-5nmsB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oee LARGE SUBUNIT
TERMINASE

(Phage D6E) 		no annotation 3 LYS A  73
ASP A 394
ASP A 385
 None
 1.06A 2br4A-5oeeA:
2.8		 2br4A-5oeeA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0h 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		3 LYS f 230
ASP f 188
ASP f 179
 None
 1.10A 2br4A-5t0hf:
undetectable		 2br4A-5t0hf:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		3 LYS A 444
ASP A 131
ASP A 219
 None
 1.08A 2br4A-5uamA:
undetectable		 2br4A-5uamA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wru PROBABLE INORGANIC
PYROPHOSPHATASE

(Plasmodium
falciparum) 		no annotation 3 LYS A 282
ASP A 235
ASP A 200
 None
 1.12A 2br4A-5wruA:
undetectable		 2br4A-5wruA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		3 LYS O 968
ASP O1232
ASP O1184
 None
 0.93A 2br4A-5x0yO:
3.3		 2br4A-5x0yO:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4j UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 3 LYS A  -1
ASP A 170
ASP A 273
 None
 1.00A 2br4A-5x4jA:
undetectable		 2br4A-5x4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		3 LYS A 648
ASP A 394
ASP A 362
 None
 1.00A 2br4A-5x7hA:
undetectable		 2br4A-5x7hA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8g 2-SUCCINYLBENZOATE--
COA LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LYS A 160
ASP A 367
ASP A 381
 None
 1.03A 2br4A-5x8gA:
undetectable		 2br4A-5x8gA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S17-B,
PUTATIVE
GUANINE
NUCLEOTIDE-BINDING
PROTEIN BETA
SUBUNIT, PUTATIVE

(Trichomonas
vaginalis;
Trichomonas
vaginalis) 		PF00833
(Ribosomal_S17e)
no annotation 		3 LYS g 230
ASP R  30
ASP g 124
 None
 1.05A 2br4A-5xyig:
undetectable		 2br4A-5xyig:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 3 LYS A 207
ASP A 314
ASP A 370
 None
 0.93A 2br4A-5y3jA:
undetectable		 2br4A-5y3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens;
Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		3 LYS A  94
ASP A 109
ASP B 319
 None
 1.03A 2br4A-5y3rA:
undetectable		 2br4A-5y3rA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A 500
ASP A  63
ASP A 113
 None
 1.10A 2br4A-5y58A:
2.2		 2br4A-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR

(Homo sapiens) 		no annotation 3 LYS A2100
ASP A2560
ASP A2331
 None
 1.12A 2br4A-5yz0A:
undetectable		 2br4A-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 3 LYS A 427
ASP A 895
ASP A 921
 None
 0.82A 2br4A-6bf6A:
undetectable		 2br4A-6bf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbr


(;
) 		no annotation
no annotation 		3 LYS B  38
ASP A 683
ASP A 624
 None
 0.93A 2br4A-6dbrB:
undetectable		 2br4A-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC

(Spinacia
oleracea;
Spinacia
oleracea) 		no annotation
no annotation 		3 LYS g  59
ASP C 348
ASP C 171
 None
 0.94A 2br4A-6fkhg:
undetectable		 2br4A-6fkhg:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fks -

(-) 		no annotation 3 LYS A  77
ASP A 268
ASP A 270
 None
 1.11A 2br4A-6fksA:
undetectable		 2br4A-6fksA:
undetectable