SIMILAR PATTERNS OF AMINO ACIDS FOR 2BR4_A_SAMA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 LEU A 562
GLY A 536
CYH A 472
ALA A 538
ALA A 459
 None
None
None
FAD  A 750 (-3.7A)
None
 1.09A 2br4A-1amoA:
4.3		 2br4A-1amoA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  24
GLY A  85
ARG A 355
ARG A  31
ALA A  84
 None
 1.11A 2br4A-1bucA:
undetectable		 2br4A-1bucA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bx0 PROTEIN
(FERREDOXIN:NADP+
OXIDOREDUCTASE)

(Spinacia
oleracea) 		PF00175
(NAD_binding_1) 		5 LEU A 200
GLY A 173
CYH A 114
ALA A 175
ALA A  98
 None
None
None
FAD  A 315 ( 4.0A)
None
 1.08A 2br4A-1bx0A:
3.7		 2br4A-1bx0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dz3 STAGE 0 SPORULATION
PROTEIN A

(Geobacillus
stearothermophilus) 		PF00072
(Response_reg) 		5 LEU A 105
CYH A  40
ASP A  55
ALA A   8
ALA A  34
 None
 1.05A 2br4A-1dz3A:
2.5		 2br4A-1dz3A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I

(Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 LEU A 208
LEU A 197
GLY A  77
ARG A 207
ALA A  58
 None
 1.09A 2br4A-1i1qA:
undetectable		 2br4A-1i1qA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		5 LEU A 511
LEU A 458
GLY A 538
ALA A 467
ALA A 471
 None
 0.94A 2br4A-1itkA:
undetectable		 2br4A-1itkA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		5 LEU A  65
GLU A 211
GLY A   7
ALA A  39
ALA A  37
 None
 0.96A 2br4A-1ixpA:
undetectable		 2br4A-1ixpA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00465
(Fe-ADH) 		5 LEU A 308
CYH A 208
ASP A 173
ALA A 174
ALA A 238
 None
None
ZN  A 371 (-2.1A)
None
None
 1.11A 2br4A-1jpuA:
2.7		 2br4A-1jpuA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		5 LEU A 303
CYH A 204
ASP A 169
ALA A 170
ALA A 234
 None
None
ZN  A 401 (-2.4A)
None
None
 1.15A 2br4A-1kq3A:
2.5		 2br4A-1kq3A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 LEU B 459
GLU B 404
GLY B 482
SER B 414
ALA B 776
 None
 1.13A 2br4A-1n60B:
undetectable		 2br4A-1n60B:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc3 PHOSPHATE-BINDING
PROTEIN 1

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		5 LEU A 309
LEU A  30
GLY A  80
ALA A  72
ALA A  73
 None
 1.00A 2br4A-1pc3A:
undetectable		 2br4A-1pc3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)

(Nostoc sp. PCC
7119) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 LEU A 189
GLY A 158
CYH A  98
ALA A 160
ALA A  82
 None
None
None
FAD  A 304 ( 4.0A)
None
 1.06A 2br4A-1qgzA:
3.5		 2br4A-1qgzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r88 MPT51/MPB51 ANTIGEN

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		5 LEU A  87
LEU A  64
GLY A  81
SER A  75
ALA A 284
 None
 1.14A 2br4A-1r88A:
undetectable		 2br4A-1r88A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rwr FILAMENTOUS
HEMAGGLUTININ

(Bordetella
pertussis) 		PF05860
(Haemagg_act) 		5 LEU A 273
LEU A 275
GLY A 264
SER A 282
ALA A 224
 None
 1.08A 2br4A-1rwrA:
undetectable		 2br4A-1rwrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		5 GLY A  87
TYR A  89
SER A  93
ASP A 163
ALA A 164
 SAH  A 301 (-3.4A)
SAH  A 301 (-4.7A)
SAH  A 301 (-2.7A)
CA  A 305 (-2.5A)
SAH  A 301 ( 3.7A)
 0.79A 2br4A-1susA:
13.5		 2br4A-1susA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta9 GLYCEROL
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00465
(Fe-ADH) 		5 LEU A 367
CYH A 267
ASP A 232
ALA A 233
ALA A 297
 None
None
ZN  A1502 (-2.1A)
None
None
 1.05A 2br4A-1ta9A:
3.8		 2br4A-1ta9A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY B   7
ARG B 245
ASP B  85
ALA B  82
ALA B  79
 None
 1.04A 2br4A-1tqyB:
undetectable		 2br4A-1tqyB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		5 LEU A 513
LEU A 462
GLY A 533
ALA A 471
ALA A 475
 None
 1.01A 2br4A-1u2lA:
undetectable		 2br4A-1u2lA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 LEU A 453
LEU A 445
GLU A 423
GLY A 422
ALA A 425
 None
 1.07A 2br4A-1uaaA:
2.4		 2br4A-1uaaA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 276
GLU A  34
GLY A  11
ALA A 145
ALA A 307
 None
FAD  A 666 (-2.5A)
FAD  A 666 (-3.2A)
FAD  A 666 (-4.9A)
None
 0.98A 2br4A-1zk7A:
3.3		 2br4A-1zk7A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5o FERREDOXIN--NADP
REDUCTASE

(Synechococcus
sp. PCC 7002) 		PF00175
(NAD_binding_1) 		5 LEU A 288
GLY A 261
CYH A 200
ALA A 263
ALA A 184
 None
None
None
FAD  A 403 ( 4.3A)
None
 1.00A 2br4A-2b5oA:
3.8		 2br4A-2b5oA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		12 LEU A  18
LEU A  64
GLU A  87
GLY A  89
TYR A  91
SER A  95
ARG A 117
ARG A 121
CYH A 139
ASP A 160
ALA A 161
ALA A 163
 SAM  A 301 ( 4.4A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.9A)
MG  A 300 ( 3.6A)
SAM  A 301 (-3.6A)
SAM  A 301 ( 3.7A)
 0.03A 2br4A-2br4A:
38.4		 2br4A-2br4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  22
GLY A  83
TYR A  81
ALA A  86
ALA A  90
 None
 0.93A 2br4A-2cx9A:
undetectable		 2br4A-2cx9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG

(Mus musculus) 		PF01612
(DNA_pol_A_exo1) 		5 LEU A 155
GLY A  74
CYH A 103
ALA A 211
ALA A 208
 None
 1.09A 2br4A-2e6mA:
undetectable		 2br4A-2e6mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbv WERNER SYNDROME
HELICASE

(Homo sapiens) 		PF01612
(DNA_pol_A_exo1) 		5 LEU A 161
GLY A  80
CYH A 109
ALA A 217
ALA A 214
 None
 1.11A 2br4A-2fbvA:
undetectable		 2br4A-2fbvA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE

(Helicobacter
pylori) 		PF00698
(Acyl_transf_1) 		5 LEU A 176
GLY A 168
CYH A 199
ALA A 167
ALA A 156
 None
 1.03A 2br4A-2h1yA:
undetectable		 2br4A-2h1yA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h26 T-CELL SURFACE
GLYCOPROTEIN CD1B

(Homo sapiens) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		5 LEU A 259
GLY A 254
ARG A 222
ASP A 253
ALA A 252
 None
 1.05A 2br4A-2h26A:
undetectable		 2br4A-2h26A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoq PUTATIVE
HAD-HYDROLASE PH1655

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		5 LEU A  65
LEU A  36
GLY A  81
ALA A  27
ALA A  23
 None
 1.15A 2br4A-2hoqA:
undetectable		 2br4A-2hoqA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran) 		5 LEU A  24
LEU A  45
SER A  40
ALA A  33
ALA A 201
 None
 1.03A 2br4A-2it1A:
undetectable		 2br4A-2it1A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A  48
ARG A 294
ASP A 132
ALA A 129
ALA A 126
 None
 1.01A 2br4A-2iwzA:
undetectable		 2br4A-2iwzA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jww PARVALBUMIN ALPHA

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		5 LEU A  77
GLU A 101
GLY A  89
ASP A  90
ALA A  88
 None
 1.00A 2br4A-2jwwA:
undetectable		 2br4A-2jwwA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		5 LEU A 107
GLY A 104
ASP A  60
ALA A 111
ALA A  99
 None
FAD  A1535 (-3.3A)
None
FAD  A1535 ( 3.7A)
FAD  A1535 ( 4.3A)
 1.06A 2br4A-2qpmA:
undetectable		 2br4A-2qpmA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rek PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 LEU A  74
LEU A 132
GLY A 102
ARG A  70
ALA A  99
 None
 0.99A 2br4A-2rekA:
undetectable		 2br4A-2rekA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		5 LEU A 174
LEU A  90
GLY A  83
ALA A 113
ALA A 117
 None
None
SFD  A1418 ( 4.3A)
SFD  A1418 (-3.5A)
SFD  A1418 (-3.2A)
 0.85A 2br4A-2vfvA:
undetectable		 2br4A-2vfvA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrm INTRACELLULAR
SUBTILISIN PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		5 LEU A 154
LEU A 118
GLY A 127
ALA A 130
ALA A 166
 None
 1.14A 2br4A-2xrmA:
undetectable		 2br4A-2xrmA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 LEU A 389
GLY A  63
TYR A  93
ALA A 409
ALA A 650
 None
FAD  A 801 (-3.1A)
None
None
None
 0.86A 2br4A-2yr5A:
2.3		 2br4A-2yr5A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A   8
ARG A 257
ASP A  93
ALA A  90
ALA A  87
 None
 1.05A 2br4A-3e60A:
undetectable		 2br4A-3e60A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		5 LEU A 270
LEU A 176
SER A 178
CYH A 418
ALA A 202
 None
 0.98A 2br4A-3eafA:
3.6		 2br4A-3eafA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae;
Homo sapiens) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 LEU A 542
GLY A 516
CYH A 452
ALA A 518
ALA A 439
 None
None
None
FAD  A 750 ( 4.2A)
None
 1.10A 2br4A-3fjoA:
4.4		 2br4A-3fjoA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs2 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Brucella
melitensis) 		PF00793
(DAHP_synth_1) 		5 LEU A 264
LEU A  50
GLY A  53
ALA A  22
ALA A 234
 None
 1.09A 2br4A-3fs2A:
undetectable		 2br4A-3fs2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 LEU A 141
GLU A  31
GLY A   8
ALA A 132
ALA A 334
 FAD  A 444 ( 4.0A)
FAD  A 444 (-2.7A)
FAD  A 444 (-3.3A)
None
None
 0.96A 2br4A-3g5sA:
undetectable		 2br4A-3g5sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana) 		PF13847
(Methyltransf_31) 		5 LEU A 732
GLY A 725
SER A 730
ALA A 754
ALA A 752
 None
 1.08A 2br4A-3htxA:
8.2		 2br4A-3htxA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		5 LEU A 343
GLY A  82
CYH A  79
ASP A  83
ALA A  43
 None
FMT  A 403 ( 4.3A)
None
None
None
 1.11A 2br4A-3ju1A:
undetectable		 2br4A-3ju1A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k33 DEATH ON CURING
PROTEIN

(Escherichia
virus P1) 		PF02661
(Fic) 		5 LEU A   9
GLY A  65
SER A  27
ALA A  63
ALA A 104
 None
 1.12A 2br4A-3k33A:
undetectable		 2br4A-3k33A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgk ARSENICAL RESISTANCE
OPERON TRANS-ACTING
REPRESSOR ARSD

(Escherichia
coli) 		PF06953
(ArsD) 		5 LEU A  78
GLY A  99
ARG A  96
ALA A  95
ALA A  92
 None
 0.93A 2br4A-3kgkA:
undetectable		 2br4A-3kgkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lre KINESIN-LIKE PROTEIN
KIF18A

(Homo sapiens) 		PF00225
(Kinesin) 		5 LEU A 259
LEU A 312
GLY A 289
SER A 310
ALA A 352
 None
 1.14A 2br4A-3lreA:
undetectable		 2br4A-3lreA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		5 LEU A 335
LEU A 339
GLY A 321
ALA A 294
ALA A 273
 None
 0.96A 2br4A-3lscA:
undetectable		 2br4A-3lscA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhp FERREDOXIN--NADP
REDUCTASE, LEAF
ISOZYME,
CHLOROPLASTIC

(Pisum sativum) 		PF00175
(NAD_binding_1) 		5 LEU A 194
GLY A 167
CYH A 108
ALA A 169
ALA A  92
 None
None
None
FAD  A 999 ( 4.0A)
None
 1.07A 2br4A-3mhpA:
2.7		 2br4A-3mhpA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus) 		PF00079
(Serpin) 		5 LEU A 164
LEU A 106
GLY A  47
SER A 109
ALA A 300
 None
 1.05A 2br4A-3ndaA:
undetectable		 2br4A-3ndaA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfb BETA-PEPTIDYL
AMINOPEPTIDASE

(Sphingosinicella
xenopeptidilytica) 		PF03576
(Peptidase_S58) 		5 LEU A 340
GLY A 185
SER A 343
ALA A 335
ALA A 331
 None
 1.12A 2br4A-3nfbA:
undetectable		 2br4A-3nfbA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmo UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00132
(Hexapep)
PF04613
(LpxD) 		5 LEU A  92
GLY A  10
TYR A   7
ALA A  13
ALA A  18
 None
 1.11A 2br4A-3pmoA:
undetectable		 2br4A-3pmoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		5 LEU A 565
GLY A 539
CYH A 475
ALA A 541
ALA A 462
 None
None
None
FAD  A 752 ( 3.7A)
None
 1.11A 2br4A-3qfsA:
3.3		 2br4A-3qfsA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmn HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Vibrio cholerae) 		PF01648
(ACPS) 		5 LEU A  31
GLY A  46
SER A  42
ALA A  50
ALA A  10
 None
None
CL  A 128 ( 4.6A)
None
MPD  A2570 (-3.6A)
 1.01A 2br4A-3qmnA:
undetectable		 2br4A-3qmnA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		5 LEU A 329
CYH A 230
ASP A 193
ALA A 194
ALA A 260
 None
None
ZN  A 388 (-2.2A)
None
None
 1.02A 2br4A-3uhjA:
undetectable		 2br4A-3uhjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		5 LEU A 564
LEU A 511
GLY A 590
ALA A 520
ALA A 524
 None
 1.01A 2br4A-3ut2A:
undetectable		 2br4A-3ut2A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vo2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00175
(NAD_binding_1) 		5 LEU A 200
GLY A 173
CYH A 114
ALA A 175
ALA A  98
 None
None
None
FAD  A 401 ( 4.0A)
None
 1.09A 2br4A-3vo2A:
3.6		 2br4A-3vo2A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5v FERREDOXIN

(Zea mays) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 LEU A 200
GLY A 173
CYH A 114
ALA A 175
ALA A  98
 None
None
None
FAD  A 401 ( 4.0A)
None
 1.04A 2br4A-3w5vA:
3.4		 2br4A-3w5vA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		5 LEU A 510
LEU A 457
GLY A 529
ALA A 466
ALA A 470
 None
 1.06A 2br4A-3wxoA:
undetectable		 2br4A-3wxoA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az7 BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		5 GLY A 227
TYR A 261
ASP A 299
ALA A 300
ALA A 304
 None
 1.00A 2br4A-4az7A:
undetectable		 2br4A-4az7A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azc BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		5 GLY A 672
TYR A 706
ASP A 744
ALA A 745
ALA A 749
 None
 0.98A 2br4A-4azcA:
undetectable		 2br4A-4azcA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		5 LEU A 230
LEU A 110
GLY A  69
TYR A  67
ALA A 181
 None
 1.00A 2br4A-4c1oA:
undetectable		 2br4A-4c1oA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 LEU A 521
LEU A 467
GLY A 548
ALA A 476
ALA A 480
 None
 0.92A 2br4A-4c51A:
undetectable		 2br4A-4c51A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		6 GLU A 174
GLY A 202
SER A  19
ASP A 203
ALA A 206
ALA A 209
 None
 1.22A 2br4A-4e4gA:
3.7		 2br4A-4e4gA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex6 ALNB

(Streptomyces
sp. CM020) 		PF13419
(HAD_2) 		5 LEU A  20
LEU A  95
GLU A 101
GLY A 102
ALA A 217
 None
 1.11A 2br4A-4ex6A:
undetectable		 2br4A-4ex6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqg TRANSCRIPTION
ELONGATION REGULATOR
1

(Homo sapiens) 		PF01846
(FF) 		5 LEU A  54
LEU A  16
GLY A  43
ARG A   5
ALA A   8
 None
 1.06A 2br4A-4fqgA:
undetectable		 2br4A-4fqgA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE

(Escherichia
coli) 		PF00378
(ECH_1) 		6 LEU A  31
LEU A 110
GLY A  62
ARG A  81
ALA A  25
ALA A  22
 None
None
None
GOL  A 301 (-3.5A)
None
None
 1.46A 2br4A-4fzwA:
undetectable		 2br4A-4fzwA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		5 GLU A 279
GLY A 275
TYR A 125
ARG A 124
ALA A 218
 None
 0.95A 2br4A-4hpvA:
undetectable		 2br4A-4hpvA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2u ENOYL-COA HYDRATASE

(Rhodobacter
sphaeroides) 		PF16113
(ECH_2) 		5 LEU A 162
GLY A 170
ASP A 173
ALA A 174
ALA A 180
 None
 1.04A 2br4A-4j2uA:
undetectable		 2br4A-4j2uA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4i RYANODINE RECEPTOR 2

(Mus musculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		5 LEU A 436
LEU A 447
GLY A 519
ALA A 515
ALA A 512
 None
 1.15A 2br4A-4l4iA:
undetectable		 2br4A-4l4iA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 LEU A  20
CYH A 172
ASP A  44
ALA A  45
ALA A 143
 None
None
UNX  A 311 ( 3.8A)
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.4A)
 1.13A 2br4A-4lg1A:
7.9		 2br4A-4lg1A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 TYR A 210
CYH A 172
ASP A  44
ALA A  45
ALA A 143
 None
None
UNX  A 311 ( 3.8A)
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.4A)
 1.10A 2br4A-4lg1A:
7.9		 2br4A-4lg1A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE

(Serratia
plymuthica) 		PF00465
(Fe-ADH) 		5 LEU A 305
CYH A 206
ASP A 171
ALA A 172
ALA A 236
 None
None
ZN  A1000 (-2.1A)
None
None
 1.10A 2br4A-4mcaA:
2.8		 2br4A-4mcaA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oog RIBONUCLEASE 3
RIBONUCLEASE 3

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
PF00035
(dsrm)
PF00636
(Ribonuclease_3) 		5 LEU A  47
CYH C 404
ASP C 434
ALA C 431
ALA C 428
 None
 1.14A 2br4A-4oogA:
undetectable		 2br4A-4oogA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN

(Anaplasma
phagocytophilum) 		PF01596
(Methyltransf_3) 		5 LEU A  35
GLY A  64
SER A  70
ASP A 136
ALA A 137
 None
SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
MN  A 303 ( 2.7A)
SAM  A 301 ( 3.9A)
 0.83A 2br4A-4pclA:
13.9		 2br4A-4pclA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 LEU A 254
LEU A 263
GLY A 162
ALA A  93
ALA A  57
 None
 1.05A 2br4A-4uozA:
undetectable		 2br4A-4uozA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymg PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE

(Podospora
anserina) 		PF01596
(Methyltransf_3) 		5 GLY A  73
TYR A  75
SER A  79
ASP A 144
ALA A 145
 SAM  A1001 (-3.3A)
SAM  A1001 (-4.8A)
SAM  A1001 (-2.7A)
SAM  A1001 (-3.6A)
SAM  A1001 ( 3.5A)
 0.78A 2br4A-4ymgA:
14.3		 2br4A-4ymgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK

(Cupriavidus
necator) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 LEU A 129
LEU A 168
GLY A 163
TYR A 167
ALA A 146
 None
 1.05A 2br4A-5aa5A:
undetectable		 2br4A-5aa5A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 LEU A 423
LEU A 427
GLY A 398
TYR A 400
ALA A 392
 None
 1.11A 2br4A-5c3mA:
5.3		 2br4A-5c3mA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160

(Haemophilus
influenzae;
Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF02542
(YgbB) 		5 GLY E 118
CYH E 313
ASP E 211
ALA E 208
ALA E 205
 None
 1.10A 2br4A-5esvE:
undetectable		 2br4A-5esvE:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esz 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160

(Haemophilus
influenzae;
Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF02542
(YgbB) 		5 GLY C 118
CYH C 307
ASP C 211
ALA C 208
ALA C 205
 None
 1.09A 2br4A-5eszC:
undetectable		 2br4A-5eszC:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h35 MEMBRANE PROTEIN
TRIC

(Sulfolobus
solfataricus) 		PF03458
(UPF0126) 		5 LEU C 140
LEU C  37
GLY C 133
SER C  19
ALA C  44
 None
 0.99A 2br4A-5h35C:
undetectable		 2br4A-5h35C:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5j FERREDOXIN--NADP
REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1) 		5 LEU A 204
GLY A 177
CYH A 113
ALA A 179
ALA A  97
 None
None
None
FAD  A 401 ( 4.4A)
None
 1.07A 2br4A-5h5jA:
3.7		 2br4A-5h5jA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		5 LEU A 117
LEU A 207
GLY A 200
ASP A 203
ALA A 250
 TRP  A 506 ( 4.7A)
None
None
None
None
 1.09A 2br4A-5hucA:
undetectable		 2br4A-5hucA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		5 LEU A 968
LEU A 983
GLY A 958
ALA A 928
ALA A 926
 None
 1.05A 2br4A-5irmA:
undetectable		 2br4A-5irmA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 LEU A 210
GLY A  89
SER A  40
ALA A 162
ALA A 165
 BAM  A 407 (-4.3A)
BAM  A 407 (-3.4A)
None
BAM  A 407 (-3.2A)
None
 0.93A 2br4A-5jd4A:
3.1		 2br4A-5jd4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		5 LEU A 528
LEU A 475
GLY A 555
ALA A 484
ALA A 488
 None
 1.00A 2br4A-5kqiA:
undetectable		 2br4A-5kqiA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kva CAFFEOYL-COA
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF01596
(Methyltransf_3) 		5 GLY A 101
TYR A 103
SER A 107
ASP A 177
ALA A 178
 SAM  A 301 (-3.4A)
SAM  A 301 (-4.8A)
SAM  A 301 (-2.8A)
CA  A 302 ( 2.2A)
SAM  A 301 (-3.7A)
 0.73A 2br4A-5kvaA:
13.4		 2br4A-5kvaA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldt MOMP PORIN

(Campylobacter
jejuni) 		PF05538
(Campylo_MOMP) 		6 LEU A 255
LEU A 293
GLU A 232
GLY A 233
SER A 295
ASP A 216
 None
 1.35A 2br4A-5ldtA:
undetectable		 2br4A-5ldtA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		no annotation 5 LEU A  28
LEU A  49
SER A  44
ALA A  37
ALA A 209
 None
None
ATP  A 701 (-4.0A)
None
None
 1.02A 2br4A-5lj6A:
undetectable		 2br4A-5lj6A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		no annotation 5 LEU A  29
LEU A  50
SER A  45
ALA A  38
ALA A 210
 None
 1.01A 2br4A-5lj9A:
undetectable		 2br4A-5lj9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1t MUCR
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		5 LEU A 539
GLU A 502
GLY A 501
SER A 542
ALA A 491
 None
 0.91A 2br4A-5m1tA:
undetectable		 2br4A-5m1tA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
AAC) 		PF00171
(Aldedh) 		5 GLU A 175
GLY A 203
ASP A 204
ALA A 207
ALA A 210
 ADP  A 501 (-3.4A)
None
None
None
None
 1.05A 2br4A-5tjrA:
3.8		 2br4A-5tjrA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpw GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 LEU B  40
GLY B 129
SER B  43
ALA B 131
ALA B 110
 None
 1.13A 2br4A-5tpwB:
4.5		 2br4A-5tpwB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 LEU A 404
GLU A 423
GLY A 374
SER A 421
ARG A 376
 None
 1.09A 2br4A-5u03A:
undetectable		 2br4A-5u03A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7o NOSK

(Streptomyces
actuosus) 		PF12697
(Abhydrolase_6) 		5 LEU A  64
LEU A 104
GLY A 100
ALA A 109
ALA A 113
 None
 1.15A 2br4A-5v7oA:
2.7		 2br4A-5v7oA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ws4 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Acinetobacter
baumannii) 		no annotation 5 LEU A  31
LEU A  52
SER A  47
ALA A  40
ALA A 212
 None
None
AT4  A 801 (-4.1A)
None
None
 0.94A 2br4A-5ws4A:
undetectable		 2br4A-5ws4A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1y MERCURIC REDUCTASE

(Lysinibacillus
sphaericus) 		no annotation 5 LEU B 354
GLU B 114
GLY B  91
ALA B 218
ALA B 385
 FAD  B 601 (-4.6A)
FAD  B 601 (-2.6A)
FAD  B 601 (-3.3A)
FAD  B 601 ( 4.6A)
None
 1.02A 2br4A-5x1yB:
3.4		 2br4A-5x1yB:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xep CHITINASE-3-LIKE
PROTEIN 1

(Mus musculus) 		no annotation 5 LEU A  95
LEU A  67
GLY A  98
ALA A 139
ALA A 178
 None
 1.04A 2br4A-5xepA:
undetectable		 2br4A-5xepA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		5 LEU A 305
CYH A 206
ASP A 171
ALA A 172
ALA A 236
 None
None
ZN  A 401 (-2.3A)
None
None
 1.13A 2br4A-5xn8A:
2.5		 2br4A-5xn8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
ATP-BINDING PROTEIN

(Streptococcus
pneumoniae) 		no annotation 5 LEU A  29
LEU A  50
SER A  45
ALA A  38
ALA A 210
 None
None
MG  A 301 ( 4.5A)
None
None
 0.90A 2br4A-5xu1A:
undetectable		 2br4A-5xu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09251
(PhageP22-tail) 		3 LYS A 241
ASP A 395
ASP A 444
 None
 1.02A 2br4A-1clwA:
undetectable		 2br4A-1clwA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqs PROTEIN
(3-DEHYDROQUINATE
SYNTHASE)

(Aspergillus
nidulans) 		PF01761
(DHQ_synthase) 		3 LYS A 341
ASP A 156
ASP A 119
 None
None
NAD  A 400 (-3.1A)
 1.11A 2br4A-1dqsA:
3.2		 2br4A-1dqsA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR

(Homo sapiens) 		PF00439
(Bromodomain) 		3 LYS A1454
ASP A1549
ASP A1571
 None
 0.97A 2br4A-1eqfA:
undetectable		 2br4A-1eqfA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 LYS A1023
ASP A 919
ASP A 924
 None
 1.08A 2br4A-1f4hA:
2.1		 2br4A-1f4hA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTS, IRON-SULFUR
PROTEIN OF CARBON
MONOXIDE
DEHYDROGENASE
CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava;
Hydrogenophaga
pseudoflava) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 LYS A   3
ASP B 128
ASP B  50
 None
 1.03A 2br4A-1ffvA:
undetectable		 2br4A-1ffvA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		3 LYS A 341
ASP A 174
ASP A 443
 None
 0.96A 2br4A-1ileA:
undetectable		 2br4A-1ileA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 LYS A 337
ASP A 322
ASP A 302
 None
 0.98A 2br4A-1m53A:
undetectable		 2br4A-1m53A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 LYS A  13
ASP A 344
ASP A 306
 None
 1.05A 2br4A-1mroA:
undetectable		 2br4A-1mroA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oc2 DTDP-GLUCOSE
4,6-DEHYDRATASE

(Streptococcus
suis) 		PF16363
(GDP_Man_Dehyd) 		3 LYS A 333
ASP A 279
ASP A 276
 None
 0.79A 2br4A-1oc2A:
4.8		 2br4A-1oc2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		3 LYS A  11
ASP A 199
ASP A 300
 None
 0.81A 2br4A-1ofuA:
3.2		 2br4A-1ofuA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		3 LYS A 283
ASP A 252
ASP A 349
 None
 1.17A 2br4A-1olpA:
undetectable		 2br4A-1olpA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 LYS A 344
ASP A  25
ASP A  69
 None
 1.08A 2br4A-1ykwA:
undetectable		 2br4A-1ykwA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))

(Streptococcus
pyogenes) 		PF00390
(malic)
PF03949
(Malic_M) 		3 LYS A 206
ASP A 162
ASP A 138
 None
None
MG  A 801 (-2.6A)
 0.79A 2br4A-2a9fA:
4.1		 2br4A-2a9fA:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		3 LYS A  65
ASP A 116
ASP A 138
 SAM  A 301 (-2.6A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.7A)
 0.04A 2br4A-2br4A:
38.4		 2br4A-2br4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		3 LYS A 293
ASP A 411
ASP A 485
 None
 1.11A 2br4A-2c3oA:
2.5		 2br4A-2c3oA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyg BETA-1, 3-GLUCANANSE

(Musa acuminata) 		PF00332
(Glyco_hydro_17) 		3 LYS A 317
ASP A  62
ASP A  86
 None
 1.17A 2br4A-2cygA:
undetectable		 2br4A-2cygA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef0 ORNITHINE
CARBAMOYLTRANSFERASE

(Thermus
thermophilus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 LYS A  34
ASP A 141
ASP A 220
 None
 0.96A 2br4A-2ef0A:
3.5		 2br4A-2ef0A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcw ALPHA-2-MACROGLOBULI
N
RECEPTOR-ASSOCIATED
PROTEIN
LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens;
Homo sapiens) 		PF06401
(Alpha-2-MRAP_C)
PF00057
(Ldl_recept_a) 		3 LYS A 289
ASP B 118
ASP B  97
 None
CA  B3001 (-3.3A)
None
 1.06A 2br4A-2fcwA:
undetectable		 2br4A-2fcwA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		3 LYS A 921
ASP A  56
ASP A 243
 None
 0.98A 2br4A-2fgeA:
undetectable		 2br4A-2fgeA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 LYS X 545
ASP X 537
ASP X 535
 None
 1.12A 2br4A-2iv2X:
2.5		 2br4A-2iv2X:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 LYS A 352
ASP A 412
ASP A 386
 None
 0.84A 2br4A-2ji9A:
3.6		 2br4A-2ji9A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lg1 A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		PF00169
(PH) 		3 LYS A  56
ASP A 179
ASP A 177
 None
 0.95A 2br4A-2lg1A:
undetectable		 2br4A-2lg1A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qki COMPLEMENT C3

(Homo sapiens) 		PF01759
(NTR)
PF07677
(A2M_recep) 		3 LYS C1335
ASP C1477
ASP C1535
 None
 0.98A 2br4A-2qkiC:
undetectable		 2br4A-2qkiC:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn8 RETICULON-4-INTERACT
ING PROTEIN 1

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		3 LYS A 381
ASP A 239
ASP A 254
 None
 1.08A 2br4A-2vn8A:
6.4		 2br4A-2vn8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		3 LYS A 468
ASP A 447
ASP A 444
 None
 1.03A 2br4A-2xu0A:
undetectable		 2br4A-2xu0A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT ALPHA
NITRILE HYDRATASE
SUBUNIT BETA

(Rhodococcus
erythropolis;
Rhodococcus
erythropolis) 		PF02979
(NHase_alpha)
PF02211
(NHase_beta) 		3 LYS A 115
ASP B  53
ASP B 165
 CSO  A 114 ( 3.7A)
None
None
 1.01A 2br4A-2zpbA:
undetectable		 2br4A-2zpbA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		3 LYS A  11
ASP A 312
ASP A 300
 None
 0.86A 2br4A-3abbA:
undetectable		 2br4A-3abbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alf CHITINASE, CLASS V

(Nicotiana
tabacum) 		PF00704
(Glyco_hydro_18) 		3 LYS A 311
ASP A 184
ASP A 263
 None
EDO  A 359 (-4.5A)
None
 0.93A 2br4A-3alfA:
undetectable		 2br4A-3alfA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		3 LYS A 309
ASP A 185
ASP A 261
 None
 0.88A 2br4A-3aquA:
undetectable		 2br4A-3aquA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1

(Rattus
norvegicus) 		PF06325
(PrmA) 		3 LYS A 310
ASP A 300
ASP A 345
 None
 1.06A 2br4A-3b3jA:
5.2		 2br4A-3b3jA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkx SAM-DEPENDENT
METHYLTRANSFERASE

(Lactobacillus
paracasei) 		PF13649
(Methyltransf_25) 		3 LYS A   1
ASP A 220
ASP A 225
 None
 1.09A 2br4A-3bkxA:
6.7		 2br4A-3bkxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdj DEGV FAMILY PROTEIN

([Eubacterium]
eligens) 		PF02645
(DegV) 		3 LYS A  12
ASP A  40
ASP A  46
 None
 0.84A 2br4A-3fdjA:
2.3		 2br4A-3fdjA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fho ATP-DEPENDENT RNA
HELICASE DBP5

(Schizosaccharomyces
pombe) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 LYS A 389
ASP A 264
ASP A 261
 None
 1.04A 2br4A-3fhoA:
3.4		 2br4A-3fhoA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iac GLUCURONATE
ISOMERASE

(Salmonella
enterica) 		PF02614
(UxaC) 		3 LYS A 192
ASP A 317
ASP A  58
 None
 1.15A 2br4A-3iacA:
undetectable		 2br4A-3iacA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib6 UNCHARACTERIZED
PROTEIN

(Listeria
monocytogenes) 		PF13419
(HAD_2) 		3 LYS A  96
ASP A  22
ASP A  27
 None
 0.92A 2br4A-3ib6A:
undetectable		 2br4A-3ib6A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imh GALACTOSE-1-EPIMERAS
E

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		3 LYS A  14
ASP A 129
ASP A 131
 None
 1.01A 2br4A-3imhA:
undetectable		 2br4A-3imhA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		no annotation 3 LYS K 469
ASP K 391
ASP K 385
 None
 0.85A 2br4A-3jblK:
undetectable		 2br4A-3jblK:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moz MYO-INOSITOL
HEXAPHOSPHATE
PHOSPHOHYDROLASE

(Selenomonas
ruminantium) 		PF14566
(PTPlike_phytase) 		3 LYS A 312
ASP A 153
ASP A  59
 5IP  A 401 (-3.0A)
5IP  A 401 ( 4.9A)
None
 1.13A 2br4A-3mozA:
undetectable		 2br4A-3mozA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		3 LYS A  84
ASP A 266
ASP A 203
 None
 1.13A 2br4A-3mwgA:
undetectable		 2br4A-3mwgA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 3 LYS B 134
ASP B 238
ASP B 248
 None
 1.16A 2br4A-3n3bB:
undetectable		 2br4A-3n3bB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE

(Enterovirus A) 		PF00680
(RdRP_1) 		3 LYS A 172
ASP A 233
ASP A 359
 BUP  A 464 ( 4.9A)
None
None
 1.17A 2br4A-3n6nA:
undetectable		 2br4A-3n6nA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocd SOXA

(Starkeya
novella) 		no annotation 3 LYS A 274
ASP A 208
ASP A 203
 HEC  A 401 (-3.4A)
None
None
 1.11A 2br4A-3ocdA:
undetectable		 2br4A-3ocdA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB

(Campylobacter
jejuni) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		3 LYS A  65
ASP A 295
ASP A 289
 ADP  A 336 (-2.7A)
None
None
 1.02A 2br4A-3pfiA:
undetectable		 2br4A-3pfiA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A 105
ASP A 204
ASP A 241
 EDO  A 417 (-3.5A)
None
None
 1.10A 2br4A-3qfvA:
undetectable		 2br4A-3qfvA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qil CLATHRIN HEAVY CHAIN
1

(Bos taurus) 		PF00637
(Clathrin) 		3 LYS A1522
ASP A1546
ASP A1575
 None
 0.93A 2br4A-3qilA:
undetectable		 2br4A-3qilA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		3 LYS A1159
ASP A1058
ASP A 800
 None
 1.15A 2br4A-3s5kA:
undetectable		 2br4A-3s5kA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssm METHYLTRANSFERASE

(Micromonospora
griseorubida) 		no annotation 3 LYS A 175
ASP A 234
ASP A 252
 SAH  A 601 (-3.1A)
SAH  A 601 (-2.8A)
SAH  A 601 (-3.6A)
 0.70A 2br4A-3ssmA:
12.4		 2br4A-3ssmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stb SINGLE DOMAIN
ANTIBODY VHH
RNA-EDITING COMPLEX
PROTEIN MP42

(Lama glama;
Trypanosoma
brucei) 		PF07686
(V-set)
no annotation 		3 LYS A   4
ASP C 327
ASP C 331
 None
 1.13A 2br4A-3stbA:
undetectable		 2br4A-3stbA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7c CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		3 LYS A 119
ASP A  76
ASP A  38
 None
NAD  A 279 (-3.2A)
NAD  A 279 (-2.8A)
 1.06A 2br4A-3t7cA:
5.3		 2br4A-3t7cA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		3 LYS A 241
ASP A 464
ASP A 478
 None
 0.96A 2br4A-3tsyA:
2.2		 2br4A-3tsyA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A
ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B

(Bacillus
subtilis;
Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C)
PF12705
(PDDEXK_1) 		3 LYS B 161
ASP B 626
ASP A  58
 None
 1.14A 2br4A-3u44B:
2.4		 2br4A-3u44B:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uow GMP SYNTHETASE

(Plasmodium
falciparum) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		3 LYS A   6
ASP A 236
ASP A 413
 None
 1.15A 2br4A-3uowA:
2.5		 2br4A-3uowA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		3 LYS A 206
ASP A 313
ASP A 369
 None
 0.90A 2br4A-3wpeA:
undetectable		 2br4A-3wpeA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt0 CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		3 LYS A  17
ASP A 210
ASP A 237
 ATP  A 400 (-3.0A)
None
None
 0.77A 2br4A-3wt0A:
undetectable		 2br4A-3wt0A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 LYS B2307
ASP B2377
ASP B2608
 None
 1.10A 2br4A-4bedB:
undetectable		 2br4A-4bedB:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bum VOLTAGE-DEPENDENT
ANION CHANNEL 2

(Danio rerio) 		PF01459
(Porin_3) 		3 LYS X  42
ASP X 100
ASP X 128
 None
 1.17A 2br4A-4bumX:
undetectable		 2br4A-4bumX:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bum VOLTAGE-DEPENDENT
ANION CHANNEL 2

(Danio rerio) 		PF01459
(Porin_3) 		3 LYS X 256
ASP X  16
ASP X   9
 None
 1.02A 2br4A-4bumX:
undetectable		 2br4A-4bumX:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		3 LYS V1338
ASP V1114
ASP V1033
 None
 1.05A 2br4A-4bxsV:
undetectable		 2br4A-4bxsV:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2t DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		3 LYS A 562
ASP A 550
ASP A 527
 None
 0.70A 2br4A-4c2tA:
undetectable		 2br4A-4c2tA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		3 LYS A 593
ASP A 321
ASP A 359
 None
 1.07A 2br4A-4dxbA:
undetectable		 2br4A-4dxbA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4f THREONINE SYNTHASE

(Brucella
melitensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		3 LYS A 112
ASP A 309
ASP A 282
 PLP  A 501 (-1.7A)
None
None
 1.13A 2br4A-4f4fA:
2.3		 2br4A-4f4fA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l08 HYDROLASE,
ISOCHORISMATASE
FAMILY

(Pseudomonas
putida) 		no annotation 3 LYS B   4
ASP B 192
ASP B 198
 None
 1.10A 2br4A-4l08B:
2.2		 2br4A-4l08B:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb5 CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18)
PF16403
(DUF5011) 		3 LYS A 171
ASP A 376
ASP A 385
 None
 0.99A 2br4A-4mb5A:
undetectable		 2br4A-4mb5A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8c THERMOSTABLE NPPASE

(Geobacillus
stearothermophilus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 LYS A  56
ASP A  12
ASP A 148
 None
 1.05A 2br4A-4o8cA:
3.6		 2br4A-4o8cA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN

(Legionella
pneumophila) 		PF13855
(LRR_8) 		3 LYS A  92
ASP A 189
ASP A 237
 None
 1.00A 2br4A-4q62A:
undetectable		 2br4A-4q62A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnh MOTILITY REGULATOR

(Pseudomonas
aeruginosa) 		PF00563
(EAL)
PF00990
(GGDEF) 		3 LYS A1244
ASP A1310
ASP A1333
 None
MG  A1501 ( 2.6A)
None
 0.95A 2br4A-4rnhA:
undetectable		 2br4A-4rnhA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uri CHITINASE-RELATED
AGGLUTININ

(Robinia
pseudoacacia) 		PF00704
(Glyco_hydro_18) 		3 LYS A 302
ASP A 186
ASP A 191
 None
 1.16A 2br4A-4uriA:
undetectable		 2br4A-4uriA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3d HB3VAR03 CIDRA
DOMAIN
ENDOTHELIAL PROTEIN
C RECEPTOR

(Plasmodium
falciparum;
Homo sapiens) 		PF03011
(PFEMP)
PF16497
(MHC_I_3) 		3 LYS A 661
ASP A 576
ASP B  21
 None
 1.14A 2br4A-4v3dA:
undetectable		 2br4A-4v3dA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y2w ALANINE RACEMASE 1

(Caldanaerobacter
subterraneus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 LYS A 241
ASP A 175
ASP A 178
 None
 1.11A 2br4A-4y2wA:
undetectable		 2br4A-4y2wA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aey PLASMID SEGREGATION
PROTEIN PARM

(Escherichia
coli) 		PF06406
(StbA) 		3 LYS A  13
ASP A 177
ASP A 194
 ANP  A 500 (-2.3A)
None
None
 1.09A 2br4A-5aeyA:
undetectable		 2br4A-5aeyA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		3 LYS A   1
ASP A 777
ASP A 782
 None
 1.07A 2br4A-5azaA:
undetectable		 2br4A-5azaA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		3 LYS A 180
ASP A 169
ASP A  97
 None
 1.16A 2br4A-5e8lA:
undetectable		 2br4A-5e8lA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftx SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 3 LYS A 868
ASP A 757
ASP A 728
 None
 0.96A 2br4A-5ftxA:
undetectable		 2br4A-5ftxA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3

(Rattus
norvegicus) 		PF12796
(Ank_2)
PF16511
(FERM_f0) 		3 LYS A  36
ASP A 210
ASP A 239
 EDO  A1377 (-2.3A)
None
None
 1.02A 2br4A-5g4xA:
undetectable		 2br4A-5g4xA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grs STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		no annotation
no annotation 		3 LYS I 992
ASP A 597
ASP A 616
 None
 1.14A 2br4A-5grsI:
undetectable		 2br4A-5grsI:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		3 LYS A 259
ASP A 956
ASP A 958
 None
 1.10A 2br4A-5ijlA:
undetectable		 2br4A-5ijlA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jdp VOLTAGE-DEPENDENT
ANION-SELECTIVE
CHANNEL PROTEIN 1

(Homo sapiens) 		PF01459
(Porin_3) 		3 LYS A 109
ASP A 128
ASP A   9
 None
 1.17A 2br4A-5jdpA:
undetectable		 2br4A-5jdpA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 LYS A 781
ASP A 704
ASP A 756
 None
MG  A 802 (-2.5A)
None
 1.09A 2br4A-5jp0A:
undetectable		 2br4A-5jp0A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis) 		PF00291
(PALP) 		3 LYS B  41
ASP B 242
ASP B 245
 None
 1.16A 2br4A-5kzmB:
undetectable		 2br4A-5kzmB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN6

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		3 LYS Q  90
ASP Q  34
ASP Q  32
 None
 1.13A 2br4A-5mpdQ:
undetectable		 2br4A-5mpdQ:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		3 LYS A  46
ASP A 495
ASP A 506
 None
 0.98A 2br4A-5mq6A:
undetectable		 2br4A-5mq6A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		3 LYS A 590
ASP A 717
ASP A 772
 None
 0.74A 2br4A-5n6uA:
undetectable		 2br4A-5n6uA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nms 25.3 KDA HEAT SHOCK
PROTEIN,
CHLOROPLASTIC
25.3 KDA HEAT SHOCK
PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00011
(HSP20)
PF00011
(HSP20) 		3 LYS B  83
ASP A 100
ASP B 131
 None
 1.14A 2br4A-5nmsB:
undetectable		 2br4A-5nmsB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oee LARGE SUBUNIT
TERMINASE

(Phage D6E) 		no annotation 3 LYS A  73
ASP A 394
ASP A 385
 None
 1.06A 2br4A-5oeeA:
2.8		 2br4A-5oeeA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0h 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		3 LYS f 230
ASP f 188
ASP f 179
 None
 1.10A 2br4A-5t0hf:
undetectable		 2br4A-5t0hf:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		3 LYS A 444
ASP A 131
ASP A 219
 None
 1.08A 2br4A-5uamA:
undetectable		 2br4A-5uamA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wru PROBABLE INORGANIC
PYROPHOSPHATASE

(Plasmodium
falciparum) 		no annotation 3 LYS A 282
ASP A 235
ASP A 200
 None
 1.12A 2br4A-5wruA:
undetectable		 2br4A-5wruA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		3 LYS O 968
ASP O1232
ASP O1184
 None
 0.93A 2br4A-5x0yO:
3.3		 2br4A-5x0yO:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4j UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 3 LYS A  -1
ASP A 170
ASP A 273
 None
 1.00A 2br4A-5x4jA:
undetectable		 2br4A-5x4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		3 LYS A 648
ASP A 394
ASP A 362
 None
 1.00A 2br4A-5x7hA:
undetectable		 2br4A-5x7hA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8g 2-SUCCINYLBENZOATE--
COA LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LYS A 160
ASP A 367
ASP A 381
 None
 1.03A 2br4A-5x8gA:
undetectable		 2br4A-5x8gA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S17-B,
PUTATIVE
GUANINE
NUCLEOTIDE-BINDING
PROTEIN BETA
SUBUNIT, PUTATIVE

(Trichomonas
vaginalis;
Trichomonas
vaginalis) 		PF00833
(Ribosomal_S17e)
no annotation 		3 LYS g 230
ASP R  30
ASP g 124
 None
 1.05A 2br4A-5xyig:
undetectable		 2br4A-5xyig:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 3 LYS A 207
ASP A 314
ASP A 370
 None
 0.93A 2br4A-5y3jA:
undetectable		 2br4A-5y3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5

(Homo sapiens;
Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		3 LYS A  94
ASP A 109
ASP B 319
 None
 1.03A 2br4A-5y3rA:
undetectable		 2br4A-5y3rA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A 500
ASP A  63
ASP A 113
 None
 1.10A 2br4A-5y58A:
2.2		 2br4A-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR

(Homo sapiens) 		no annotation 3 LYS A2100
ASP A2560
ASP A2331
 None
 1.12A 2br4A-5yz0A:
undetectable		 2br4A-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 3 LYS A 427
ASP A 895
ASP A 921
 None
 0.82A 2br4A-6bf6A:
undetectable		 2br4A-6bf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbr


(;
) 		no annotation
no annotation 		3 LYS B  38
ASP A 683
ASP A 624
 None
 0.93A 2br4A-6dbrB:
undetectable		 2br4A-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC
ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC

(Spinacia
oleracea;
Spinacia
oleracea) 		no annotation
no annotation 		3 LYS g  59
ASP C 348
ASP C 171
 None
 0.94A 2br4A-6fkhg:
undetectable		 2br4A-6fkhg:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fks -

(-) 		no annotation 3 LYS A  77
ASP A 268
ASP A 270
 None
 1.11A 2br4A-6fksA:
undetectable		 2br4A-6fksA:
undetectable