SIMILAR PATTERNS OF AMINO ACIDS FOR 2BM9_D_SAMD301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg8 ENDOPOLYGALACTURONAS
E

(Fusarium
verticillioides) 		PF00295
(Glyco_hydro_28) 		3 ASP A 170
ASP A 106
ASN A 210
 None
 0.61A 2bm9D-1hg8A:
undetectable		 2bm9D-1hg8A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		3 ASP A 217
ASP A 159
ASN A 243
 None
 0.59A 2bm9D-1idjA:
undetectable		 2bm9D-1idjA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2w SORBITOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		3 ASP A  36
ASP A  59
ASN A  86
 None
 0.86A 2bm9D-1k2wA:
6.1		 2bm9D-1k2wA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5c ENDOPOLYGALACTURONAS
E

(Chondrostereum
purpureum) 		PF00295
(Glyco_hydro_28) 		3 ASP A 139
ASP A  78
ASN A 171
 None
 0.75A 2bm9D-1k5cA:
undetectable		 2bm9D-1k5cA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		3 ASP A 173
ASP A 113
ASN A 205
 None
 0.70A 2bm9D-1nhcA:
undetectable		 2bm9D-1nhcA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oc2 DTDP-GLUCOSE
4,6-DEHYDRATASE

(Streptococcus
suis) 		PF16363
(GDP_Man_Dehyd) 		3 ASP A 279
ASP A 276
ASN A 208
 None
 0.85A 2bm9D-1oc2A:
4.5		 2bm9D-1oc2A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		3 ASP A 184
ASP A 187
ASN A 228
 CA  A 601 (-2.3A)
None
None
 0.85A 2bm9D-1ot5A:
undetectable		 2bm9D-1ot5A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pbw PHOSPHATIDYLINOSITOL
3-KINASE

(Homo sapiens) 		PF00620
(RhoGAP) 		3 ASP A 184
ASP A 178
ASN A 157
 None
 0.80A 2bm9D-1pbwA:
undetectable		 2bm9D-1pbwA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcx PECTIN LYASE B

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		3 ASP A 217
ASP A 159
ASN A 243
 None
 0.70A 2bm9D-1qcxA:
undetectable		 2bm9D-1qcxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ted PKS18

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 ASP A 389
ASP A 308
ASN A 300
 ASP  A 389 ( 0.6A)
ASP  A 308 ( 0.5A)
ASN  A 300 ( 0.6A)
 0.74A 2bm9D-1tedA:
undetectable		 2bm9D-1tedA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		3 ASP A 590
ASP A 243
ASN A 293
 None
 0.63A 2bm9D-1uaaA:
undetectable		 2bm9D-1uaaA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhh SONIC HEDGEHOG

(Mus musculus) 		PF01085
(HH_signal) 		3 ASP A  96
ASP A 130
ASN A  92
 None
 0.67A 2bm9D-1vhhA:
undetectable		 2bm9D-1vhhA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcn TRANSCRIPTION
ELONGATION PROTEIN
NUSA

(Escherichia
coli) 		PF14520
(HHH_5) 		3 ASP A 458
ASP A 433
ASN A 428
 None
 0.61A 2bm9D-1wcnA:
undetectable		 2bm9D-1wcnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjl ANNEXIN A2

(Homo sapiens) 		PF00191
(Annexin) 		3 ASP A  38
ASP A  70
ASN A  62
 None
 0.73A 2bm9D-1xjlA:
undetectable		 2bm9D-1xjlA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzo HYPOTHETICAL PROTEIN
YPMQ

(Bacillus
subtilis) 		PF02630
(SCO1-SenC) 		3 ASP A 151
ASP A 166
ASN A 153
 None
CD  A1004 (-2.2A)
None
 0.74A 2bm9D-1xzoA:
undetectable		 2bm9D-1xzoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		3 ASP A 205
ASP A  87
ASN A 181
 SF4  A1000 ( 3.9A)
None
None
 0.86A 2bm9D-2b3xA:
undetectable		 2bm9D-2b3xA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
agalactiae) 		PF01368
(DHH)
PF02833
(DHHA2) 		3 ASP A 228
ASP A 258
ASN A 192
 None
 0.74A 2bm9D-2enxA:
undetectable		 2bm9D-2enxA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
carnosus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		3 ASP A 465
ASP A 456
ASN A 353
 None
SO4  A 900 ( 4.6A)
None
 0.78A 2bm9D-2hroA:
undetectable		 2bm9D-2hroA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyk BETA-1,3-GLUCANASE

(Nocardiopsis
sp. F96) 		PF00722
(Glyco_hydro_16) 		3 ASP A 237
ASP A  13
ASN A  57
 CA  A 477 ( 3.3A)
None
None
 0.84A 2bm9D-2hykA:
undetectable		 2bm9D-2hykA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq7 ENDOPOLYGALACTURONAS
E

(Colletotrichum
lupini) 		PF00295
(Glyco_hydro_28) 		3 ASP A 165
ASP A 104
ASN A 197
 None
 0.70A 2bm9D-2iq7A:
undetectable		 2bm9D-2iq7A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL

(Arabidopsis
thaliana) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ASP A 213
ASP A 235
ASN A 208
 None
 0.57A 2bm9D-2ix5A:
undetectable		 2bm9D-2ix5A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ASP A  99
ASP A  80
ASN A 104
 None
 0.63A 2bm9D-2j6iA:
5.2		 2bm9D-2j6iA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfg EH DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF12763
(EF-hand_4) 		3 ASP A 102
ASP A  54
ASN A  64
 None
 0.76A 2bm9D-2kfgA:
undetectable		 2bm9D-2kfgA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n1l BCL-6 COREPRESSOR

(Homo sapiens) 		PF16553
(PUFD) 		3 ASP A  38
ASP A  82
ASN A  21
 None
 0.79A 2bm9D-2n1lA:
undetectable		 2bm9D-2n1lA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 ASP A  18
ASP A  12
ASN A   5
 None
 0.73A 2bm9D-2nz9A:
undetectable		 2bm9D-2nz9A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE

(Rhodobacter
sphaeroides) 		PF00221
(Lyase_aromatic) 		3 ASP A 320
ASP A  20
ASN A 215
 None
 0.75A 2bm9D-2o78A:
undetectable		 2bm9D-2o78A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 ASP A 394
ASP A 389
ASN A 400
 None
 0.84A 2bm9D-2qn0A:
undetectable		 2bm9D-2qn0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4n MULTIFUNCTIONAL
PROTEIN SUR E

(Salmonella
enterica) 		PF01975
(SurE) 		3 ASP A 213
ASP A 218
ASN A  96
 None
None
PO4  A1257 (-3.2A)
 0.61A 2bm9D-2v4nA:
undetectable		 2bm9D-2v4nA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2u UPF0026 PROTEIN
MJ0257

(Methanocaldococcus
jannaschii) 		PF04055
(Radical_SAM)
PF08608
(Wyosine_form) 		3 ASP A 294
ASP A 291
ASN A  38
 None
 0.69A 2bm9D-2z2uA:
2.5		 2bm9D-2z2uA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ASP A 283
ASP A 246
ASN A 324
 CA  A 701 ( 2.2A)
None
None
 0.81A 2bm9D-3bc9A:
undetectable		 2bm9D-3bc9A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN
POLYPROTEIN
POLYPROTEIN

(Senecavirus A;
Senecavirus A;
Senecavirus A) 		no annotation
PF00073
(Rhv)
no annotation 		3 ASP B  21
ASP A 122
ASN D  16
 None
 0.80A 2bm9D-3cjiB:
undetectable		 2bm9D-3cjiB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dgt ENDO-1,3-BETA-GLUCAN
ASE

(Streptomyces
sioyaensis) 		PF00722
(Glyco_hydro_16) 		3 ASP A 269
ASP A  15
ASN A  65
 MG  A 800 (-3.1A)
None
None
 0.85A 2bm9D-3dgtA:
undetectable		 2bm9D-3dgtA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epc PROTEIN VP1
PROTEIN VP2

(Enterovirus C;
Enterovirus C) 		PF00073
(Rhv)
PF00073
(Rhv) 		3 ASP 1 285
ASP 2 135
ASN 2 183
 None
 0.80A 2bm9D-3epc1:
undetectable		 2bm9D-3epc1:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN

([Eubacterium]
rectale) 		PF13614
(AAA_31) 		3 ASP A 181
ASP A 219
ASN A 176
 None
 0.84A 2bm9D-3fkqA:
undetectable		 2bm9D-3fkqA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE

(Methanosarcina
mazei) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 ASP A 369
ASP A 393
ASN A 372
 None
 0.84A 2bm9D-3g79A:
4.9		 2bm9D-3g79A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbx GLUTAMATE
DECARBOXYLASE 1

(Arabidopsis
thaliana) 		PF00282
(Pyridoxal_deC) 		3 ASP A 220
ASP A 191
ASN A 225
 None
 0.60A 2bm9D-3hbxA:
2.9		 2bm9D-3hbxA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgo 12-OXOPHYTODIENOATE
REDUCTASE 3

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		3 ASP A 193
ASP A 243
ASN A 201
 None
 0.73A 2bm9D-3hgoA:
undetectable		 2bm9D-3hgoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 ASP A1981
ASP A2002
ASN A1994
 None
 0.78A 2bm9D-3jb9A:
undetectable		 2bm9D-3jb9A:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF01823
(MACPF) 		3 ASP A 259
ASP A 254
ASN A 249
 None
 0.69A 2bm9D-3kk7A:
undetectable		 2bm9D-3kk7A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwl UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 3 ASP A 141
ASP A 190
ASN A 174
 None
 0.65A 2bm9D-3kwlA:
undetectable		 2bm9D-3kwlA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldf PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.776

(Streptococcus
mutans) 		PF10672
(Methyltrans_SAM) 		3 ASP A 271
ASP A 242
ASN A 299
 SAH  A 401 (-3.2A)
SAH  A 401 (-2.8A)
None
 0.64A 2bm9D-3ldfA:
8.5		 2bm9D-3ldfA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		3 ASP A  81
ASP A 169
ASN A 221
 None
SAH  A 301 (-3.6A)
None
 0.71A 2bm9D-3lgaA:
10.8		 2bm9D-3lgaA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhi PUTATIVE
6-PHOSPHOGLUCONOLACT
ONASE

(Neisseria
gonorrhoeae) 		PF01182
(Glucosamine_iso) 		3 ASP A  56
ASP A  58
ASN A  91
 None
 0.77A 2bm9D-3lhiA:
undetectable		 2bm9D-3lhiA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1u PUTATIVE
GAMMA-D-GLUTAMYL-L-D
IAMINO ACID
ENDOPEPTIDASE

(Desulfovibrio
vulgaris) 		PF00877
(NLPC_P60)
PF12912
(N_NLPC_P60)
PF12913
(SH3_6)
PF12914
(SH3_7) 		3 ASP A 332
ASP A 339
ASN A 351
 GOL  A   1 (-3.1A)
GOL  A   3 (-2.8A)
ACT  A  13 ( 4.1A)
 0.81A 2bm9D-3m1uA:
undetectable		 2bm9D-3m1uA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgk INTRACELLULAR
PROTEASE/AMIDASE
RELATED ENZYME (THIJ
FAMILY)

(Clostridium
acetobutylicum) 		PF01965
(DJ-1_PfpI) 		3 ASP A 194
ASP A 161
ASN A 122
 None
 0.75A 2bm9D-3mgkA:
undetectable		 2bm9D-3mgkA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nib TEG14

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		3 ASP A 184
ASP A 159
ASN A   2
 None
 0.81A 2bm9D-3nibA:
undetectable		 2bm9D-3nibA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o38 SHORT CHAIN
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		3 ASP A  50
ASP A  77
ASN A 104
 None
 0.44A 2bm9D-3o38A:
6.1		 2bm9D-3o38A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pct CLASS C ACID
PHOSPHATASE

(Pasteurella
multocida) 		PF03767
(Acid_phosphat_B) 		3 ASP A 222
ASP A 180
ASN A 159
 None
 0.72A 2bm9D-3pctA:
3.1		 2bm9D-3pctA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3peh ENDOPLASMIN HOMOLOG

(Plasmodium
falciparum) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 ASP A 302
ASP A 298
ASN A 281
 None
 0.83A 2bm9D-3pehA:
undetectable		 2bm9D-3pehA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q08 CHLORITE DISMUTASE

(Dechloromonas
aromatica) 		PF06778
(Chlor_dismutase) 		3 ASP A 195
ASP A 193
ASN A 152
 None
 0.61A 2bm9D-3q08A:
undetectable		 2bm9D-3q08A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r50 IPOMOELIN

(Ipomoea batatas) 		PF01419
(Jacalin) 		3 ASP A  81
ASP A  83
ASN A  57
 None
 0.85A 2bm9D-3r50A:
undetectable		 2bm9D-3r50A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf5 MACROPHAGE MIGRATION
INHIBITORY FACTOR

(Ancylostoma
ceylanicum) 		PF01187
(MIF) 		3 ASP A  71
ASP A 100
ASN A  31
 None
 0.72A 2bm9D-3rf5A:
undetectable		 2bm9D-3rf5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sju KETO REDUCTASE

(Streptomyces
griseoruber) 		PF00106
(adh_short) 		3 ASP A 107
ASP A 101
ASN A  92
 None
 0.84A 2bm9D-3sjuA:
5.8		 2bm9D-3sjuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tat TYROSINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 ASP A 162
ASP A 137
ASN A 171
 None
 0.75A 2bm9D-3tatA:
3.3		 2bm9D-3tatA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkn NUCLEOPORIN NUP82

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A 176
ASP A 340
ASN A 171
 None
 0.77A 2bm9D-3tknA:
undetectable		 2bm9D-3tknA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		3 ASP A 821
ASP A 849
ASN A 845
 None
 0.85A 2bm9D-3un9A:
undetectable		 2bm9D-3un9A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8c GLUCOSE-REPRESSIBLE
ALCOHOL
DEHYDROGENASE
TRANSCRIPTIONAL
EFFECTOR

(Saccharomyces
cerevisiae) 		PF03372
(Exo_endo_phos)
PF13855
(LRR_8) 		3 ASP D 340
ASP D 386
ASN D 181
 None
 0.69A 2bm9D-4b8cD:
undetectable		 2bm9D-4b8cD:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce5 AT-OMEGATA

(Aspergillus
terreus) 		PF01063
(Aminotran_4) 		3 ASP A  57
ASP A  50
ASN A 181
 None
None
CL  A1327 (-3.1A)
 0.81A 2bm9D-4ce5A:
undetectable		 2bm9D-4ce5A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmf AMINOTRANSFERASE

([Nectria]
haematococca) 		PF01063
(Aminotran_4) 		3 ASP A  55
ASP A  48
ASN A 180
 None
 0.83A 2bm9D-4cmfA:
undetectable		 2bm9D-4cmfA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu9 BETA-GALACTOSIDASE

(Streptococcus
pneumoniae) 		no annotation 3 ASP A1838
ASP A1848
ASN A1863
 None
 0.65A 2bm9D-4cu9A:
undetectable		 2bm9D-4cu9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		3 ASP A 845
ASP A 864
ASN A 820
 None
 0.83A 2bm9D-4ecnA:
undetectable		 2bm9D-4ecnA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN

(Plasmodium
falciparum) 		PF00092
(VWA) 		3 ASP A 135
ASP A 170
ASN A  95
 None
None
EDO  A 306 (-4.8A)
 0.78A 2bm9D-4f1kA:
undetectable		 2bm9D-4f1kA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbo E7

(Thermobifida
fusca) 		PF03067
(LPMO_10) 		3 ASP A  76
ASP A 120
ASN A  79
 None
None
IOD  A 311 (-4.2A)
 0.85A 2bm9D-4gboA:
undetectable		 2bm9D-4gboA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irn PROLYL-ACP
DEHYDROGENASE

([Oscillatoria]
sp. PCC 6506) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ASP A 166
ASP A 191
ASN A 161
 None
 0.70A 2bm9D-4irnA:
undetectable		 2bm9D-4irnA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jja HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		3 ASP A 129
ASP A 159
ASN A 164
 None
 0.73A 2bm9D-4jjaA:
3.0		 2bm9D-4jjaA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4moz FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Slackia
heliotrinireducens) 		PF01791
(DeoC) 		3 ASP A  52
ASP A  43
ASN A 272
 None
 0.73A 2bm9D-4mozA:
undetectable		 2bm9D-4mozA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkj HEMAGGLUTININ HA2

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		3 ASP A  56
ASP A  51
ASN A 115
 None
 0.83A 2bm9D-4nkjA:
undetectable		 2bm9D-4nkjA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PGT135 HEAVY CHAIN
PROTEIN M TD

(Homo sapiens;
Mycoplasma
genitalium) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		3 ASP H  31
ASP H  27
ASN M 452
 None
 0.85A 2bm9D-4nzrH:
undetectable		 2bm9D-4nzrH:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		3 ASP A 587
ASP A 469
ASN A 568
 None
 0.60A 2bm9D-4p7hA:
undetectable		 2bm9D-4p7hA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q20 SENSOR PROTEIN DIVL

(Caulobacter
vibrioides) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		3 ASP A 662
ASP A 631
ASN A 623
 None
 0.77A 2bm9D-4q20A:
undetectable		 2bm9D-4q20A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q34 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12697
(Abhydrolase_6) 		3 ASP A 176
ASP A 183
ASN A 202
 None
 0.72A 2bm9D-4q34A:
undetectable		 2bm9D-4q34A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb9 ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycolicibacterium
smegmatis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 ASP A 352
ASP A 317
ASN A 373
 None
 0.78A 2bm9D-4qb9A:
undetectable		 2bm9D-4qb9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		3 ASP A 136
ASP A  51
ASN A  42
 None
 0.73A 2bm9D-4r0xA:
undetectable		 2bm9D-4r0xA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9i SERPIN-18

(Bombyx mori) 		PF00079
(Serpin) 		3 ASP A  33
ASP A 275
ASN A 382
 None
 0.78A 2bm9D-4r9iA:
undetectable		 2bm9D-4r9iA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uug AMINE TRANSAMINASE

(Aspergillus
fumigatus) 		PF01063
(Aminotran_4) 		3 ASP A  55
ASP A  48
ASN A 180
 None
 0.81A 2bm9D-4uugA:
undetectable		 2bm9D-4uugA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzf 1,3-BETA-GLUCANASE

(Mycobacterium
tuberculosis) 		PF00722
(Glyco_hydro_16) 		3 ASP A 289
ASP A  60
ASN A 111
 CA  A 401 (-3.2A)
None
None
 0.81A 2bm9D-4wzfA:
undetectable		 2bm9D-4wzfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
thermoresistibile) 		PF00722
(Glyco_hydro_16) 		3 ASP A 254
ASP A  27
ASN A  78
 CD  A 302 ( 2.3A)
None
None
 0.83A 2bm9D-4xdqA:
undetectable		 2bm9D-4xdqA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgq CELL DIVISION CYCLE
PROTEIN 123

(Schizosaccharomyces
pombe) 		PF07065
(D123) 		3 ASP A 233
ASP A 211
ASN A 201
 None
 0.80A 2bm9D-4zgqA:
undetectable		 2bm9D-4zgqA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN

(Coprinopsis
cinerea) 		PF03664
(Glyco_hydro_62) 		3 ASP A 268
ASP A 321
ASN A 272
 None
 0.74A 2bm9D-5b6tA:
undetectable		 2bm9D-5b6tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 ASP A  37
ASP A  77
ASN A  23
 None
 0.78A 2bm9D-5dfaA:
undetectable		 2bm9D-5dfaA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		3 ASP X 348
ASP X 154
ASN X 341
 None
 0.85A 2bm9D-5evyX:
undetectable		 2bm9D-5evyX:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1p PTMO8

(Streptomyces
platensis) 		PF13561
(adh_short_C2) 		3 ASP A  37
ASP A  64
ASN A  91
 None
 0.56A 2bm9D-5f1pA:
5.3		 2bm9D-5f1pA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuk MROUPO

(Marasmius
rotula) 		PF01328
(Peroxidase_2) 		3 ASP A  87
ASP A 136
ASN A 100
 None
 0.78A 2bm9D-5fukA:
undetectable		 2bm9D-5fukA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gan SPLICEOSOMAL PROTEIN
DIB1

(Saccharomyces
cerevisiae) 		PF02966
(DIM1) 		3 ASP D  94
ASP D 136
ASN D  99
 U  W  32 ( 4.4A)
None
None
 0.40A 2bm9D-5ganD:
undetectable		 2bm9D-5ganD:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipy FLAVIN-CONTAINING
MONOOXYGENASE

(Roseovarius
nubinhibens) 		PF00743
(FMO-like) 		3 ASP A  83
ASP A 385
ASN A 323
 None
 0.67A 2bm9D-5ipyA:
undetectable		 2bm9D-5ipyA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		3 ASP A 552
ASP A 753
ASN A 557
 None
 0.81A 2bm9D-5l46A:
2.4		 2bm9D-5l46A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL

(Bos taurus) 		PF00346
(Complex1_49kDa) 		3 ASP D 241
ASP D 295
ASN D 237
 None
 0.77A 2bm9D-5lc5D:
undetectable		 2bm9D-5lc5D:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7f MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1,ANNEXIN A2

(Homo sapiens) 		no annotation 3 ASP A 577
ASP A 609
ASN A 601
 None
 0.64A 2bm9D-5n7fA:
undetectable		 2bm9D-5n7fA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN

(Chaetomium
thermophilum) 		PF12569
(NARP1)
PF13432
(TPR_16) 		3 ASP A 437
ASP A 408
ASN A 444
 None
 0.68A 2bm9D-5nnpA:
undetectable		 2bm9D-5nnpA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v77 UNCHARACTERIZED
PROTEIN

(Neisseria
gonorrhoeae) 		no annotation 3 ASP A  50
ASP A  86
ASN A  53
 None
 0.63A 2bm9D-5v77A:
undetectable		 2bm9D-5v77A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x49 PROBABLE XAA-PRO
AMINOPEPTIDASE 3

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		3 ASP A 131
ASP A 217
ASN A 102
 None
 0.84A 2bm9D-5x49A:
undetectable		 2bm9D-5x49A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ypz COFB

(Escherichia
coli) 		no annotation 3 ASP A 175
ASP A 150
ASN A 144
 None
 0.55A 2bm9D-5ypzA:
undetectable		 2bm9D-5ypzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zxd -

(-) 		no annotation 3 ASP A 215
ASP A 209
ASN A 194
 None
 0.77A 2bm9D-5zxdA:
undetectable		 2bm9D-5zxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azt ASPARAGINYL
ENDOPEPTIDASE 1

(Helianthus
annuus) 		no annotation 3 ASP A 142
ASP A 196
ASN A 188
 None
 0.67A 2bm9D-6aztA:
undetectable		 2bm9D-6aztA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4m MONOTREME LACTATION
PROTEIN

(Ornithorhynchus
anatinus) 		no annotation 3 ASP A 290
ASP A 288
ASN A 295
 None
 0.63A 2bm9D-6b4mA:
undetectable		 2bm9D-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b8a DNA-BINDING
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		no annotation 3 ASP A 131
ASP A 150
ASN A 220
 None
 0.83A 2bm9D-6b8aA:
undetectable		 2bm9D-6b8aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnf PHOSPHOETHANOLAMINE
TRANSFERASE

(Moraxella sp.
HMSC061H09) 		no annotation 3 ASP A 418
ASP A 490
ASN A 416
 None
 0.85A 2bm9D-6bnfA:
undetectable		 2bm9D-6bnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvg PROTEIN-N(PI)-PHOSPH
OHISTIDINE-SUGAR
PHOSPHOTRANSFERASE
(ENZYME II OF THE
PHOSPHOTRANSFERASE
SYSTEM) (PTS SYSTEM
GLUCOSE-SPECIFIC
IIBC COMPONENT)

(Bacillus cereus) 		no annotation 3 ASP A 384
ASP A 217
ASN A 387
 None
 0.82A 2bm9D-6bvgA:
undetectable		 2bm9D-6bvgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z 24-STEROL
C-METHYLTRANSFERASE

(Haloferax
volcanii) 		no annotation 3 ASP A  69
ASP A  44
ASN A  77
 SAH  A 301 (-2.7A)
None
None
 0.76A 2bm9D-6f5zA:
9.0		 2bm9D-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens) 		no annotation 3 ASP B  96
ASP B  26
ASN B 101
 None
 0.70A 2bm9D-6faeB:
undetectable		 2bm9D-6faeB:
undetectable