SIMILAR PATTERNS OF AMINO ACIDS FOR 2BM9_D_SAMD301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Cyberlindnera
saturnus) 		PF00291
(PALP) 		5 LEU A  55
LEU A  11
SER A  43
ALA A  85
ALA A 127
 None
 1.11A 2bm9D-1f2dA:
2.3		 2bm9D-1f2dA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTS, IRON-SULFUR
PROTEIN OF CARBON
MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		5 LEU A 116
LEU A 155
GLU A  91
GLY A  92
ALA A 147
 None
 1.14A 2bm9D-1ffvA:
undetectable		 2bm9D-1ffvA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcb GAL6 HG (EMTS)
DERIVATIVE

(Saccharomyces
cerevisiae) 		PF03051
(Peptidase_C1_2) 		5 LEU A 288
GLY A 142
CYH A  73
ALA A 453
ALA A 370
 None
None
HG  A 904 ( 2.1A)
HG  A 904 (-4.8A)
None
 1.06A 2bm9D-1gcbA:
undetectable		 2bm9D-1gcbA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I

(Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 LEU A 208
LEU A 197
GLY A  77
ARG A 207
ALA A  58
 None
 1.15A 2bm9D-1i1qA:
undetectable		 2bm9D-1i1qA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		5 LEU A 511
LEU A 458
GLY A 538
ALA A 467
ALA A 471
 None
 0.97A 2bm9D-1itkA:
undetectable		 2bm9D-1itkA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 LEU A 305
LEU A 314
TYR A 351
ALA A 321
ALA A 324
 None
 1.14A 2bm9D-1k72A:
undetectable		 2bm9D-1k72A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc3 PHOSPHATE-BINDING
PROTEIN 1

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		5 LEU A 309
LEU A  30
GLY A  80
ALA A  72
ALA A  73
 None
 0.98A 2bm9D-1pc3A:
undetectable		 2bm9D-1pc3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)

(Nostoc sp. PCC
7119) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 LEU A 189
GLY A 158
CYH A  98
ALA A 160
ALA A  82
 None
None
None
FAD  A 304 ( 4.0A)
None
 1.19A 2bm9D-1qgzA:
3.2		 2bm9D-1qgzA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta9 GLYCEROL
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00465
(Fe-ADH) 		5 LEU A 367
GLU A 239
CYH A 267
ALA A 233
ALA A 297
 None
 1.05A 2bm9D-1ta9A:
3.6		 2bm9D-1ta9A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		5 LEU A 513
LEU A 462
GLY A 533
ALA A 471
ALA A 475
 None
 1.07A 2bm9D-1u2lA:
undetectable		 2bm9D-1u2lA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwu HYPOTHETICAL PROTEIN
FLJ21935

(Homo sapiens) 		no annotation 5 LEU A  54
LEU A  33
GLU A  69
GLY A  70
SER A  39
 None
 1.10A 2bm9D-1wwuA:
undetectable		 2bm9D-1wwuA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 LEU A 342
LEU A 340
GLY A 387
TYR A 329
ALA A  87
 None
 1.09A 2bm9D-1xc6A:
undetectable		 2bm9D-1xc6A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 125
GLU A  34
GLY A  11
ALA A 145
ALA A 307
 None
FAD  A 666 (-2.5A)
FAD  A 666 (-3.2A)
FAD  A 666 (-4.9A)
None
 1.11A 2bm9D-1zk7A:
3.2		 2bm9D-1zk7A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5o FERREDOXIN--NADP
REDUCTASE

(Synechococcus
sp. PCC 7002) 		PF00175
(NAD_binding_1) 		5 LEU A 288
GLY A 261
CYH A 200
ALA A 263
ALA A 184
 None
None
None
FAD  A 403 ( 4.3A)
None
 1.16A 2bm9D-2b5oA:
3.8		 2bm9D-2b5oA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		12 LEU A  18
LEU A  64
LYS A  65
GLU A  87
GLY A  89
TYR A  91
SER A  95
ARG A 117
ARG A 121
CYH A 139
ALA A 161
ALA A 163
 SAM  A 301 ( 4.4A)
SAM  A 301 (-4.2A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.6A)
SAM  A 301 ( 3.7A)
 0.53A 2bm9D-2br4A:
34.2		 2bm9D-2br4A:
99.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE

(Thermus
thermophilus) 		PF00483
(NTP_transferase) 		5 LEU A 215
LEU A  89
GLY A 227
ARG A 214
ALA A 226
 None
 1.01A 2bm9D-2cu2A:
undetectable		 2bm9D-2cu2A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  22
GLY A  83
TYR A  81
ALA A  86
ALA A  90
 None
 0.92A 2bm9D-2cx9A:
undetectable		 2bm9D-2cx9A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbv WERNER SYNDROME
HELICASE

(Homo sapiens) 		PF01612
(DNA_pol_A_exo1) 		5 LEU A 161
GLY A  80
CYH A 109
ALA A 217
ALA A 214
 None
 1.10A 2bm9D-2fbvA:
undetectable		 2bm9D-2fbvA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hig 6-PHOSPHO-1-FRUCTOKI
NASE

(Trypanosoma
brucei) 		PF00365
(PFK) 		5 GLY A 277
SER A 233
CYH A 293
ALA A 280
ALA A 284
 None
 1.20A 2bm9D-2higA:
undetectable		 2bm9D-2higA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN

(Haemophilus
influenzae) 		PF01547
(SBP_bac_1) 		5 LEU A  30
GLU A  57
SER A  35
ALA A  12
ALA A 261
 None
 1.18A 2bm9D-2o69A:
undetectable		 2bm9D-2o69A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcn S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE

(Geobacillus
kaustophilus) 		PF03737
(RraA-like) 		5 GLU A 101
TYR A  26
CYH A  83
ALA A  79
ALA A  82
 None
 1.18A 2bm9D-2pcnA:
undetectable		 2bm9D-2pcnA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila) 		PF13378
(MR_MLE_C) 		5 LEU A  81
LEU A  85
GLY A  44
ALA A 128
ALA A 124
 None
 0.97A 2bm9D-2pgeA:
undetectable		 2bm9D-2pgeA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		5 LEU A 730
LEU A 737
CYH A 644
ALA A 707
ALA A 636
 None
 1.18A 2bm9D-2rdyA:
undetectable		 2bm9D-2rdyA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rek PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 LEU A  74
LEU A 132
GLY A 102
ARG A  70
ALA A  99
 None
 1.05A 2bm9D-2rekA:
undetectable		 2bm9D-2rekA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rli SCO2 PROTEIN
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF02630
(SCO1-SenC) 		5 LEU A 125
LEU A 144
LYS A 143
GLY A 242
ALA A 227
 None
 1.15A 2bm9D-2rliA:
undetectable		 2bm9D-2rliA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 150
LEU A 180
GLY A  16
ALA A  65
ALA A  60
 LEU  A 150 ( 0.5A)
LEU  A 180 ( 0.6A)
GLY  A  16 ( 0.0A)
ALA  A  65 ( 0.0A)
ALA  A  60 ( 0.0A)
 1.19A 2bm9D-2vbfA:
3.1		 2bm9D-2vbfA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		5 LEU A 174
LEU A  90
GLY A  83
ALA A 113
ALA A 117
 None
None
SFD  A1418 ( 4.3A)
SFD  A1418 (-3.5A)
SFD  A1418 (-3.2A)
 1.13A 2bm9D-2vfvA:
undetectable		 2bm9D-2vfvA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		5 LEU A 308
LEU A 317
TYR A 354
ALA A 324
ALA A 327
 None
 1.13A 2bm9D-2xfgA:
undetectable		 2bm9D-2xfgA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 LEU A 389
GLU A  94
GLY A  63
ALA A 409
ALA A 650
 None
FAD  A 801 (-2.7A)
FAD  A 801 (-3.1A)
None
None
 1.18A 2bm9D-2yr5A:
3.0		 2bm9D-2yr5A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 LEU A 410
LEU A  67
GLU A  21
GLY A 391
ALA A 394
 None
 1.14A 2bm9D-2zxhA:
3.1		 2bm9D-2zxhA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350

(Thermus
thermophilus) 		PF00582
(Usp) 		5 LEU A 228
LEU A 238
GLY A 241
ALA A 167
ALA A 163
 LEU  A 228 ( 0.6A)
LEU  A 238 ( 0.6A)
GLY  A 241 ( 0.0A)
ALA  A 167 ( 0.0A)
ALA  A 163 ( 0.0A)
 1.17A 2bm9D-3ab7A:
2.5		 2bm9D-3ab7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b70 ENOYL REDUCTASE

(Aspergillus
terreus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 236
LEU A 185
GLY A 141
SER A 188
ALA A 135
 None
 1.13A 2bm9D-3b70A:
4.8		 2bm9D-3b70A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		5 LEU A 322
LEU A 326
GLU A 121
GLY A 149
ARG A 157
 None
None
HIU  A 502 (-2.9A)
None
None
 1.10A 2bm9D-3bptA:
undetectable		 2bm9D-3bptA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 130
GLY A 161
SER A 105
ALA A 164
ALA A   6
 None
 1.18A 2bm9D-3eyaA:
2.5		 2bm9D-3eyaA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		5 LEU A 316
GLU A 179
GLY A 180
SER A 176
ALA A 352
 FAD  A1001 ( 4.0A)
None
S3H  A1002 ( 4.3A)
None
None
 1.17A 2bm9D-3h8lA:
3.2		 2bm9D-3h8lA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl0 MALEYLACETATE
REDUCTASE

(Agrobacterium
fabrum) 		PF00465
(Fe-ADH) 		5 LEU A 298
LEU A 169
ARG A 297
ALA A 202
ALA A 215
 None
 1.17A 2bm9D-3hl0A:
2.5		 2bm9D-3hl0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES26
40S RIBOSOMAL
PROTEIN US11

(Plasmodium
falciparum;
Plasmodium
falciparum) 		PF01283
(Ribosomal_S26e)
PF00411
(Ribosomal_S11) 		5 LEU 3  67
GLY P 109
ARG 3  42
ALA P 112
ALA P 115
 None
 1.13A 2bm9D-3j7a3:
undetectable		 2bm9D-3j7a3:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k33 DEATH ON CURING
PROTEIN

(Escherichia
virus P1) 		PF02661
(Fic) 		5 LEU A   9
GLY A  65
SER A  27
ALA A  63
ALA A 104
 None
 0.98A 2bm9D-3k33A:
undetectable		 2bm9D-3k33A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k85 D-GLYCERO-D-MANNO-HE
PTOSE 1-PHOSPHATE
KINASE

(Bacteroides
thetaiotaomicron) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 151
GLU A  72
CYH A  61
ALA A  77
ALA A  56
 None
 1.16A 2bm9D-3k85A:
undetectable		 2bm9D-3k85A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		5 LEU A 335
LEU A 339
GLY A 321
ALA A 294
ALA A 273
 None
 1.02A 2bm9D-3lscA:
undetectable		 2bm9D-3lscA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		5 LEU A 277
LEU A  48
TYR A 204
ALA A 191
ALA A 196
 None
 1.12A 2bm9D-3m0gA:
undetectable		 2bm9D-3m0gA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus) 		PF00079
(Serpin) 		5 LEU A 164
LEU A 106
GLY A  47
SER A 109
ALA A 300
 None
 1.08A 2bm9D-3ndaA:
undetectable		 2bm9D-3ndaA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 LEU A 372
LEU A 492
CYH A 353
ALA A 366
ALA A 363
 None
 1.15A 2bm9D-3ne5A:
undetectable		 2bm9D-3ne5A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 LEU A 294
GLU A  34
GLY A   9
ALA A 285
ALA A 447
 None
FAD  A 479 (-3.0A)
FAD  A 479 (-3.3A)
None
None
 1.07A 2bm9D-3nksA:
2.1		 2bm9D-3nksA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF02854
(MIF4G) 		5 LEU A 243
LEU A 225
GLU A 223
GLY A 220
ALA A 214
 None
 1.12A 2bm9D-3rk6A:
undetectable		 2bm9D-3rk6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsc CALG2

(Micromonospora
echinospora) 		PF04101
(Glyco_tran_28_C) 		5 LEU A 185
LEU A 102
TYR A 392
ALA A 386
ALA A 383
 None
 1.19A 2bm9D-3rscA:
3.2		 2bm9D-3rscA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		5 LEU B 967
LEU B 934
GLY B 959
SER B 936
ALA B 961
 None
 1.13A 2bm9D-3s4wB:
undetectable		 2bm9D-3s4wB:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		5 LEU A 329
GLU A 200
CYH A 230
ALA A 194
ALA A 260
 None
 1.08A 2bm9D-3uhjA:
undetectable		 2bm9D-3uhjA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		5 LEU A 564
LEU A 511
GLY A 590
ALA A 520
ALA A 524
 None
 0.93A 2bm9D-3ut2A:
undetectable		 2bm9D-3ut2A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vly NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A 110
LEU A 125
GLY A 162
SER A 127
ALA A 164
 None
 1.05A 2bm9D-3vlyA:
undetectable		 2bm9D-3vlyA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09754
(PAC2) 		5 LEU A 153
GLY A 139
TYR A 141
ALA A 190
ALA A 189
 None
AU  A 304 ( 3.7A)
None
None
AU  A 303 (-4.1A)
 1.14A 2bm9D-3vr0A:
undetectable		 2bm9D-3vr0A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5v FERREDOXIN

(Zea mays) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 LEU A 200
GLY A 173
CYH A 114
ALA A 175
ALA A  98
 None
None
None
FAD  A 401 ( 4.0A)
None
 1.18A 2bm9D-3w5vA:
3.6		 2bm9D-3w5vA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		5 LEU A 510
LEU A 457
GLY A 529
ALA A 466
ALA A 470
 None
 1.06A 2bm9D-3wxoA:
undetectable		 2bm9D-3wxoA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 LEU A 521
LEU A 467
GLY A 548
ALA A 476
ALA A 480
 None
 0.92A 2bm9D-4c51A:
undetectable		 2bm9D-4c51A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		5 LEU A 328
LEU A 337
TYR A 374
ALA A 344
ALA A 347
 None
 1.14A 2bm9D-4doeA:
undetectable		 2bm9D-4doeA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyo ASPARTYL
AMINOPEPTIDASE

(Homo sapiens) 		PF02127
(Peptidase_M18) 		5 LEU A 224
LEU A 228
GLY A 138
ALA A 137
ALA A 243
 None
 1.19A 2bm9D-4dyoA:
undetectable		 2bm9D-4dyoA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT

(Homo sapiens) 		PF16203
(ERCC3_RAD25_C) 		5 LEU A 701
GLU A 697
GLY A 695
ARG A 553
ALA A 694
 None
 1.18A 2bm9D-4ernA:
4.0		 2bm9D-4ernA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqg TRANSCRIPTION
ELONGATION REGULATOR
1

(Homo sapiens) 		PF01846
(FF) 		5 LEU A  54
LEU A  16
GLY A  43
ARG A   5
ALA A   8
 None
 1.19A 2bm9D-4fqgA:
undetectable		 2bm9D-4fqgA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE

(Escherichia
coli) 		PF00378
(ECH_1) 		6 LEU A  31
LEU A 110
GLY A  62
ARG A  81
ALA A  25
ALA A  22
 None
None
None
GOL  A 301 (-3.5A)
None
None
 1.50A 2bm9D-4fzwA:
undetectable		 2bm9D-4fzwA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Mycolicibacterium
thermoresistibile) 		PF16113
(ECH_2) 		5 LEU A 282
LEU A 286
GLU A  91
GLY A 119
ARG A 127
 None
 1.18A 2bm9D-4hdtA:
undetectable		 2bm9D-4hdtA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inz SOLUBLE EPOXIDE
HYDROLASE

(Bacillus
megaterium) 		PF00561
(Abhydrolase_1) 		6 LEU A  55
LEU A  75
GLY A 101
TYR A 202
ALA A 100
ALA A 119
 None
None
PEG  A 302 ( 3.9A)
None
None
None
 1.42A 2bm9D-4inzA:
2.2		 2bm9D-4inzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 LEU A 277
LEU A  47
TYR A 204
ALA A 191
ALA A 196
 None
 1.18A 2bm9D-4llsA:
undetectable		 2bm9D-4llsA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 LEU A  98
LEU A 148
GLY A 138
ALA A 136
ALA A  29
 None
 1.11A 2bm9D-4nbqA:
undetectable		 2bm9D-4nbqA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofq PUTATIVE CELL
SURFACE PROTEIN

(Streptococcus
pyogenes) 		PF16364
(Antigen_C) 		5 LEU A1259
GLY A1269
SER A1266
ALA A1270
ALA A1272
 None
 1.14A 2bm9D-4ofqA:
undetectable		 2bm9D-4ofqA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 722
LEU A 757
GLY A 733
CYH A 783
ALA A 780
 None
 1.15A 2bm9D-4oliA:
undetectable		 2bm9D-4oliA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A 215
TYR A 132
CYH A 110
ALA A 259
ALA A  26
 None
 1.12A 2bm9D-4oqjA:
undetectable		 2bm9D-4oqjA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG

(Homo sapiens;
Homo sapiens) 		PF08514
(STAG)
no annotation 		5 LEU B 351
LEU A 473
SER A 471
ALA A 428
ALA A 427
 None
 1.18A 2bm9D-4pjuB:
undetectable		 2bm9D-4pjuB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Bacillus
anthracis) 		PF00588
(SpoU_methylase) 		5 LEU A   7
LEU A 136
GLY A  17
ALA A  20
ALA A  24
 None
SAH  A 201 ( 4.3A)
None
None
None
 1.15A 2bm9D-4pzkA:
2.8		 2bm9D-4pzkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1t GLUTAMATE 5-KINASE

(Burkholderia
thailandensis) 		PF00696
(AA_kinase)
PF01472
(PUA) 		5 LEU A 125
LEU A 107
GLY A 157
ALA A 161
ALA A 233
 None
 1.16A 2bm9D-4q1tA:
2.8		 2bm9D-4q1tA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb9 ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycolicibacterium
smegmatis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 LEU A  63
LEU A 104
GLY A  60
ALA A  86
ALA A  25
 None
 1.13A 2bm9D-4qb9A:
undetectable		 2bm9D-4qb9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s12 N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Yersinia
enterocolitica) 		PF01380
(SIS) 		5 LEU A 208
LEU A  65
GLY A 137
ALA A 163
ALA A 173
 None
 1.14A 2bm9D-4s12A:
2.6		 2bm9D-4s12A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wov NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 722
LEU A 757
GLY A 733
CYH A 783
ALA A 780
 None
 1.13A 2bm9D-4wovA:
undetectable		 2bm9D-4wovA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg0 UNCHARACTERIZED
PROTEIN

(Bordetella
bronchiseptica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 LEU A 296
LEU A 324
GLY A 332
ALA A 331
ALA A 233
 None
 1.16A 2bm9D-4xg0A:
undetectable		 2bm9D-4xg0A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 LEU A 371
GLU A 345
GLY A 344
SER A 349
ALA A 381
 None
 1.13A 2bm9D-4xgjA:
undetectable		 2bm9D-4xgjA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z38 MLNA

(Bacillus
velezensis) 		no annotation 5 LEU A 414
LEU A 401
GLY A 371
SER A 429
ALA A 355
 None
None
None
FMN  A 900 (-2.6A)
None
 1.14A 2bm9D-4z38A:
undetectable		 2bm9D-4z38A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg8 ENDOGLUCANASE

(Perinereis
brevicirris) 		PF00759
(Glyco_hydro_9) 		5 LEU A 297
LEU A 306
TYR A 339
ALA A 313
ALA A 316
 None
 1.14A 2bm9D-4zg8A:
undetectable		 2bm9D-4zg8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A 284
GLU A 339
GLY A 340
ALA A 341
ALA A 343
 None
 0.96A 2bm9D-4zk3A:
undetectable		 2bm9D-4zk3A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrs ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 LEU A  16
LEU A  21
GLY A  76
ALA A 152
ALA A 155
 SEB  A 151 ( 4.8A)
None
SEB  A 151 ( 3.5A)
SEB  A 151 ( 3.4A)
SEB  A 151 ( 4.0A)
 1.17A 2bm9D-4zrsA:
undetectable		 2bm9D-4zrsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3j PUTATIVE
QUINONE-OXIDOREDUCTA
SE HOMOLOG,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 LEU A 284
LEU A 136
ARG A 119
ALA A 129
ALA A  42
 None
 1.17A 2bm9D-5a3jA:
5.5		 2bm9D-5a3jA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		5 LEU D  18
GLY D 114
TYR D  59
SER D  63
ALA D  87
 None
 1.08A 2bm9D-5a6bD:
undetectable		 2bm9D-5a6bD:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 LEU B 218
LEU B  38
CYH B 398
ALA B 211
ALA B 395
 None
 1.17A 2bm9D-5a8rB:
undetectable		 2bm9D-5a8rB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3

(Pseudomonas
aeruginosa) 		PF01471
(PG_binding_1)
PF13406
(SLT_2) 		5 LEU A 236
GLY A 143
SER A 150
ALA A 140
ALA A 341
 None
 1.20A 2bm9D-5ao8A:
undetectable		 2bm9D-5ao8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A  32
LEU A  28
GLY A 358
ALA A 362
ALA A 410
 None
 1.07A 2bm9D-5bp1A:
undetectable		 2bm9D-5bp1A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwo PROBABLE PROTEIN
PHOSPHATASE 2C 50

(Oryza sativa) 		PF00481
(PP2C) 		5 LEU A 268
LEU A 279
GLY A 275
CYH A 129
ALA A 203
 None
 1.13A 2bm9D-5gwoA:
undetectable		 2bm9D-5gwoA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy0 GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 LEU A 319
LEU A 328
TYR A 364
ALA A 335
ALA A 338
 None
 1.14A 2bm9D-5gy0A:
undetectable		 2bm9D-5gy0A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h35 MEMBRANE PROTEIN
TRIC

(Sulfolobus
solfataricus) 		PF03458
(UPF0126) 		5 LEU C 117
GLY C 108
SER C 114
ALA C 126
ALA C 157
 None
 1.19A 2bm9D-5h35C:
undetectable		 2bm9D-5h35C:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		5 GLU A 264
GLY A 268
TYR A 280
SER A 283
ALA A 271
 None
 1.15A 2bm9D-5jboA:
undetectable		 2bm9D-5jboA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 LEU A 210
GLY A  89
SER A  40
ALA A 162
ALA A 165
 BAM  A 407 (-4.3A)
BAM  A 407 (-3.4A)
None
BAM  A 407 (-3.2A)
None
 1.08A 2bm9D-5jd4A:
2.5		 2bm9D-5jd4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		5 LEU A 569
LEU A 627
GLU A 632
GLY A 633
ALA A 606
 None
 1.13A 2bm9D-5jjhA:
undetectable		 2bm9D-5jjhA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga) 		no annotation 5 LEU B 392
GLU B 596
SER B 593
ALA B 626
ALA B 623
 None
 1.18A 2bm9D-5kisB:
undetectable		 2bm9D-5kisB:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		5 LEU A 528
LEU A 475
GLY A 555
ALA A 484
ALA A 488
 None
 0.99A 2bm9D-5kqiA:
undetectable		 2bm9D-5kqiA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		no annotation 5 LEU A  28
LEU A  49
SER A  44
ALA A  37
ALA A 209
 None
None
ATP  A 701 (-4.0A)
None
None
 1.08A 2bm9D-5lj6A:
undetectable		 2bm9D-5lj6A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1t MUCR
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		5 LEU A 539
GLU A 502
GLY A 501
SER A 542
ALA A 491
 None
 0.96A 2bm9D-5m1tA:
undetectable		 2bm9D-5m1tA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxn PORIN 1

(Providencia
stuartii) 		no annotation 5 LEU A 184
GLY A 191
TYR A 182
SER A 149
ALA A 241
 None
 1.10A 2bm9D-5nxnA:
undetectable		 2bm9D-5nxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vho 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
10

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU G 191
GLU G 182
GLY G 150
ALA G 146
ALA G 114
 None
 1.15A 2bm9D-5vhoG:
undetectable		 2bm9D-5vhoG:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 5 LEU A 221
LEU A 256
GLY A 140
ALA A 232
ALA A 235
 None
 1.17A 2bm9D-5x9wA:
undetectable		 2bm9D-5x9wA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xge UNCHARACTERIZED
PROTEIN PA0861

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 443
LEU A 476
GLY A 458
ARG A 391
ALA A 450
 None
 1.09A 2bm9D-5xgeA:
undetectable		 2bm9D-5xgeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 22

(Homo sapiens) 		no annotation 5 LEU A 434
LEU A 426
GLY A 346
SER A 428
ALA A 343
 None
 1.18A 2bm9D-5y31A:
undetectable		 2bm9D-5y31A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 LEU A 178
LEU A 173
TYR A  76
SER A 165
ALA A  71
 None
 1.19A 2bm9D-5za2A:
undetectable		 2bm9D-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1

(Homo sapiens) 		no annotation 5 LEU A 550
GLU A1095
GLY A1091
ALA A 558
ALA A 562
 None
 1.17A 2bm9D-6d4jA:
undetectable		 2bm9D-6d4jA:
undetectable