SIMILAR PATTERNS OF AMINO ACIDS FOR 2BM9_C_SAMC301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8l PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)

(Escherichia
coli) 		PF01330
(RuvA_N)
PF14520
(HHH_5) 		5 LEU A  71
LEU A 139
ASN A 100
ALA A 101
ALA A 109
 None
 1.16A 2bm9C-1d8lA:
undetectable		 2bm9C-1d8lA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		5 LEU A 511
LEU A 458
GLY A 538
ALA A 467
ALA A 471
 None
 0.87A 2bm9C-1itkA:
undetectable		 2bm9C-1itkA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		5 LEU A  65
GLU A 211
GLY A   7
ALA A  39
ALA A  37
 None
 1.06A 2bm9C-1ixpA:
undetectable		 2bm9C-1ixpA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		5 GLY B 302
ASN B 112
ASN B 304
ALA B 305
ALA B  46
 None
 1.03A 2bm9C-1jtdB:
undetectable		 2bm9C-1jtdB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 LEU A 305
LEU A 314
TYR A 351
ALA A 321
ALA A 324
 None
 1.05A 2bm9C-1k72A:
undetectable		 2bm9C-1k72A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 LEU A 527
LEU A 372
GLU A 368
GLY A 367
ARG A 308
 None
 1.16A 2bm9C-1nneA:
undetectable		 2bm9C-1nneA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o70 FASCICLIN I

(Drosophila
melanogaster) 		PF02469
(Fasciclin) 		5 LEU A 544
LEU A 496
GLY A 607
TYR A 505
ASN A 606
 None
 0.99A 2bm9C-1o70A:
undetectable		 2bm9C-1o70A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 LEU A 255
GLY A 227
ASN A 247
ALA A 244
ALA A 240
 None
 1.19A 2bm9C-1ofuA:
3.1		 2bm9C-1ofuA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		6 LEU A 142
LEU A 209
ASN A 147
ASN A 205
ALA A 202
ALA A 198
 None
 1.23A 2bm9C-1otkA:
undetectable		 2bm9C-1otkA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 LYS A  27
GLU A 422
GLY A 421
ALA A  20
ALA A  16
 None
None
None
None
FAD  A1656 (-3.4A)
 1.16A 2bm9C-1qlbA:
undetectable		 2bm9C-1qlbA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)

(Escherichia
coli) 		PF01464
(SLT)
PF14718
(SLT_L) 		5 LEU A 128
LEU A 142
LYS A 141
ASN A 107
ALA A 104
 None
 1.19A 2bm9C-1qsaA:
undetectable		 2bm9C-1qsaA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5j HYPOTHETICAL PROTEIN
MJ1187

(Methanocaldococcus
jannaschii) 		PF03747
(ADP_ribosyl_GH) 		5 LEU A 139
GLY A 132
ASN A 137
ALA A 167
ALA A 163
 None
 1.08A 2bm9C-1t5jA:
undetectable		 2bm9C-1t5jA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t92 GENERAL SECRETION
PATHWAY PROTEIN G

(Klebsiella
pneumoniae) 		PF08334
(T2SSG) 		5 LEU A  89
LEU A  43
GLY A  63
ALA A  66
ALA A  70
 None
 1.18A 2bm9C-1t92A:
undetectable		 2bm9C-1t92A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		5 LEU A 513
LEU A 462
GLY A 533
ALA A 471
ALA A 475
 None
 0.93A 2bm9C-1u2lA:
undetectable		 2bm9C-1u2lA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 LEU A 453
LEU A 445
GLU A 423
GLY A 422
ALA A 425
 None
 1.15A 2bm9C-1uaaA:
2.4		 2bm9C-1uaaA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 LEU A 342
LEU A 340
GLY A 387
TYR A 329
ALA A  87
 None
 1.03A 2bm9C-1xc6A:
undetectable		 2bm9C-1xc6A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLU A  34
GLY A  11
ASN A 272
ALA A  16
ALA A  19
 FAD  A 666 (-2.5A)
FAD  A 666 (-3.2A)
SO4  A2002 (-3.8A)
None
None
 1.13A 2bm9C-1zk7A:
3.2		 2bm9C-1zk7A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvu TOPOISOMERASE IV
SUBUNIT A

(Escherichia
coli) 		PF00521
(DNA_topoisoIV)
PF03989
(DNA_gyraseA_C) 		5 LEU A  38
LEU A  99
ASN A 167
ALA A  85
ALA A  81
 None
 1.11A 2bm9C-1zvuA:
undetectable		 2bm9C-1zvuA:
16.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		11 LEU A  18
LEU A  64
LYS A  65
GLU A  87
GLY A  89
TYR A  91
ASN A  92
ARG A 121
CYH A 139
ALA A 161
ALA A 163
 SAM  A 301 ( 4.4A)
SAM  A 301 (-4.2A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.3A)
None
SAM  A 301 (-3.1A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.6A)
SAM  A 301 ( 3.7A)
 0.50A 2bm9C-2br4A:
34.5		 2bm9C-2br4A:
99.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE

(Thermus
thermophilus) 		PF00483
(NTP_transferase) 		5 LEU A 215
LEU A  89
GLY A 227
ARG A 214
ALA A 226
 None
 1.05A 2bm9C-2cu2A:
undetectable		 2bm9C-2cu2A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  22
GLY A  83
TYR A  81
ALA A  86
ALA A  90
 None
 0.90A 2bm9C-2cx9A:
undetectable		 2bm9C-2cx9A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 400
LEU A 370
GLY A 415
ASN A 417
ALA A 439
 None
 1.16A 2bm9C-2e6kA:
undetectable		 2bm9C-2e6kA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG

(Mus musculus) 		PF01612
(DNA_pol_A_exo1) 		5 LEU A 155
GLY A  74
CYH A 103
ALA A 211
ALA A 208
 None
 1.01A 2bm9C-2e6mA:
undetectable		 2bm9C-2e6mA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A 325
GLY A 305
ASN A 328
ASN A 301
ALA A 302
 None
 1.08A 2bm9C-2ep5A:
undetectable		 2bm9C-2ep5A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbv WERNER SYNDROME
HELICASE

(Homo sapiens) 		PF01612
(DNA_pol_A_exo1) 		5 LEU A 161
GLY A  80
CYH A 109
ALA A 217
ALA A 214
 None
 1.06A 2bm9C-2fbvA:
undetectable		 2bm9C-2fbvA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6r TRIOSEPHOSPHATE
ISOMERASE

(Methanocaldococcus
jannaschii) 		PF00121
(TIM) 		5 LEU A  87
GLU A 138
GLY A 176
ASN A   6
ALA A 193
 None
 1.09A 2bm9C-2h6rA:
undetectable		 2bm9C-2h6rA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoq PUTATIVE
HAD-HYDROLASE PH1655

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		5 LEU A  65
LEU A  36
GLY A  81
ALA A  27
ALA A  23
 None
 1.01A 2bm9C-2hoqA:
3.4		 2bm9C-2hoqA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibp CITRATE SYNTHASE

(Pyrobaculum
aerophilum) 		PF00285
(Citrate_synt) 		5 LEU A 208
GLY A 182
TYR A  62
ASN A 186
ALA A 185
 None
 1.09A 2bm9C-2ibpA:
undetectable		 2bm9C-2ibpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K

(Homo sapiens) 		PF00481
(PP2C) 		5 LEU A 258
LEU A 269
GLY A 265
CYH A 138
ALA A 190
 None
 1.17A 2bm9C-2iq1A:
undetectable		 2bm9C-2iq1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oap TYPE II SECRETION
SYSTEM PROTEIN

(Archaeoglobus
fulgidus) 		PF00437
(T2SSE) 		6 LEU 1 426
GLU 1 412
ASN 1 370
ASN 1 414
ALA 1 394
ALA 1 263
 None
 1.38A 2bm9C-2oap1:
undetectable		 2bm9C-2oap1:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogx MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		5 LEU A 116
GLY A  79
ASN A 112
ALA A 109
ALA A 106
 None
ATP  A 281 (-3.2A)
None
None
W  A2015 (-4.2A)
 1.11A 2bm9C-2ogxA:
undetectable		 2bm9C-2ogxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila) 		PF13378
(MR_MLE_C) 		5 LEU A  81
LEU A  85
GLY A  44
ALA A 128
ALA A 124
 None
 0.92A 2bm9C-2pgeA:
undetectable		 2bm9C-2pgeA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rek PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 LEU A  74
LEU A 132
GLY A 102
ARG A  70
ALA A  99
 None
 1.03A 2bm9C-2rekA:
undetectable		 2bm9C-2rekA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		5 LEU A 174
LEU A  90
GLY A  83
ALA A 113
ALA A 117
 None
None
SFD  A1418 ( 4.3A)
SFD  A1418 (-3.5A)
SFD  A1418 (-3.2A)
 1.02A 2bm9C-2vfvA:
undetectable		 2bm9C-2vfvA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		5 LEU A 308
LEU A 317
TYR A 354
ALA A 324
ALA A 327
 None
 1.09A 2bm9C-2xfgA:
undetectable		 2bm9C-2xfgA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		5 LEU A 168
LEU A 206
GLY A 630
ALA A 210
ALA A 214
 None
 1.19A 2bm9C-2yevA:
undetectable		 2bm9C-2yevA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfq NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Peptoniphilus
asaccharolyticus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 LYS A  94
GLY A 324
ASN A 323
ALA A 322
ALA A 300
 None
 1.15A 2bm9C-2yfqA:
undetectable		 2bm9C-2yfqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 LEU A 389
GLY A  63
TYR A  93
ALA A 409
ALA A 650
 None
FAD  A 801 (-3.1A)
None
None
None
 0.97A 2bm9C-2yr5A:
undetectable		 2bm9C-2yr5A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		5 LEU A 226
LEU A 241
GLY A  75
ALA A  71
ALA A  68
 None
 1.17A 2bm9C-3a9xA:
2.2		 2bm9C-3a9xA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1a HEMOGLOBIN SUBUNIT
ALPHA-1/2

(Capra hircus) 		PF00042
(Globin) 		5 LEU A 109
GLY A  18
ASN A  20
ALA A  21
ALA A  64
 None
 1.18A 2bm9C-3d1aA:
undetectable		 2bm9C-3d1aA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e39 PUTATIVE
NITROREDUCTASE

(Desulfovibrio
alaskensis) 		PF00881
(Nitroreductase) 		5 GLY A  37
CYH A  49
ASN A 106
ALA A 103
ALA A 100
 None
 0.96A 2bm9C-3e39A:
undetectable		 2bm9C-3e39A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e73 LANC-LIKE PROTEIN 1

(Homo sapiens) 		PF05147
(LANC_like) 		5 GLY A 327
TYR A 319
ASN A 328
ALA A 329
ALA A 348
 None
 1.18A 2bm9C-3e73A:
undetectable		 2bm9C-3e73A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 LEU A 375
GLY A 354
ASN A 356
ALA A 353
ALA A 333
 None
 1.16A 2bm9C-3g5sA:
undetectable		 2bm9C-3g5sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtz PUTATIVE TRANSLATION
INITIATION INHIBITOR

(Salmonella
enterica) 		PF01042
(Ribonuc_L-PSP) 		5 LEU A  31
TYR A 104
ASN A 101
ALA A  35
ALA A  75
 None
 1.05A 2bm9C-3gtzA:
undetectable		 2bm9C-3gtzA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF02738
(Ald_Xan_dh_C2) 		5 LEU B  61
LEU B 108
GLY B 158
ALA B 100
ALA B  96
 None
 1.08A 2bm9C-3hrdB:
undetectable		 2bm9C-3hrdB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb3 PROTEIN PHOSPHATASE
2C 16

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 LEU B 394
LEU B 405
GLY B 401
CYH B 254
ALA B 329
 None
 1.14A 2bm9C-3kb3B:
undetectable		 2bm9C-3kb3B:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldh LACTATE
DEHYDROGENASE

(Squalus
acanthias) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  66
LEU A  41
GLY A  33
ALA A  35
ALA A 248
 None
 1.16A 2bm9C-3ldhA:
2.5		 2bm9C-3ldhA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		5 LEU A 277
LEU A  48
TYR A 204
ALA A 191
ALA A 196
 None
 1.08A 2bm9C-3m0gA:
undetectable		 2bm9C-3m0gA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rht (GATASE1)-LIKE
PROTEIN

(Planctopirus
limnophila) 		PF07090
(GATase1_like) 		5 GLU A  86
GLY A  93
TYR A  88
ASN A 152
ALA A  58
 None
 1.09A 2bm9C-3rhtA:
undetectable		 2bm9C-3rhtA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF02854
(MIF4G) 		5 LEU A 243
LEU A 225
GLU A 223
GLY A 220
ALA A 214
 None
 1.10A 2bm9C-3rk6A:
undetectable		 2bm9C-3rk6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2

(Escherichia
coli) 		PF00294
(PfkB) 		5 LEU A 183
GLY A 279
CYH A 295
ALA A 261
ALA A  47
 None
 1.04A 2bm9C-3uqeA:
2.8		 2bm9C-3uqeA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		5 LEU A 564
LEU A 511
GLY A 590
ALA A 520
ALA A 524
 None
 0.89A 2bm9C-3ut2A:
undetectable		 2bm9C-3ut2A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		5 LEU A 510
LEU A 457
GLY A 529
ALA A 466
ALA A 470
 None
 0.99A 2bm9C-3wxoA:
undetectable		 2bm9C-3wxoA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b18 IMPORTIN SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 LEU A 208
GLY A 194
ASN A 238
ALA A 235
ALA A 232
 None
 1.06A 2bm9C-4b18A:
undetectable		 2bm9C-4b18A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		5 LEU A 230
LEU A 110
GLY A  69
TYR A  67
ALA A 181
 None
 1.07A 2bm9C-4c1oA:
undetectable		 2bm9C-4c1oA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 LEU A 521
LEU A 467
GLY A 548
ALA A 476
ALA A 480
 None
 0.86A 2bm9C-4c51A:
undetectable		 2bm9C-4c51A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL

(Homo sapiens) 		PF00481
(PP2C) 		5 LEU A 258
LEU A 269
GLY A 265
CYH A 138
ALA A 190
 None
 1.19A 2bm9C-4da1A:
undetectable		 2bm9C-4da1A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		5 LEU A 328
LEU A 337
TYR A 374
ALA A 344
ALA A 347
 None
 1.05A 2bm9C-4doeA:
undetectable		 2bm9C-4doeA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyo ASPARTYL
AMINOPEPTIDASE

(Homo sapiens) 		PF02127
(Peptidase_M18) 		5 LEU A 224
LEU A 228
GLY A 138
ALA A 137
ALA A 243
 None
 1.17A 2bm9C-4dyoA:
undetectable		 2bm9C-4dyoA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT

(Homo sapiens) 		PF16203
(ERCC3_RAD25_C) 		5 LEU A 701
GLU A 697
GLY A 695
ARG A 553
ALA A 694
 None
 1.19A 2bm9C-4ernA:
3.6		 2bm9C-4ernA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		5 LEU A 116
GLY A  79
ASN A 112
ALA A 109
ALA A 106
 None
ATP  A 301 (-3.2A)
None
None
8M0  A 303 (-3.3A)
 1.13A 2bm9C-4f6tA:
undetectable		 2bm9C-4f6tA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 LEU A 278
GLY A  98
ASN A 100
ALA A  97
ALA A  87
 None
 1.04A 2bm9C-4jz6A:
3.6		 2bm9C-4jz6A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		5 LEU A 577
GLY A 572
ASN A 602
ALA A 598
ALA A 596
 None
 1.09A 2bm9C-4k17A:
undetectable		 2bm9C-4k17A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		5 LEU A 315
LEU A 337
GLY A 343
ALA A  77
ALA A  81
 None
 1.13A 2bm9C-4kv7A:
4.2		 2bm9C-4kv7A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l01 TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 702
LEU A 737
GLY A 713
CYH A 763
ALA A 760
 None
 1.19A 2bm9C-4l01A:
undetectable		 2bm9C-4l01A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 LEU A 277
LEU A  47
TYR A 204
ALA A 191
ALA A 196
 None
 1.15A 2bm9C-4llsA:
undetectable		 2bm9C-4llsA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		5 GLU A 349
GLY A 348
ASN A 347
ALA A 346
ALA A 102
 None
 1.17A 2bm9C-4mnrA:
undetectable		 2bm9C-4mnrA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mup AMIDOHYDROLASE

(Agrobacterium
fabrum) 		PF04909
(Amidohydro_2) 		5 GLY A  70
ASN A 240
ASN A  71
ALA A  72
ALA A  35
 None
 1.09A 2bm9C-4mupA:
undetectable		 2bm9C-4mupA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 LEU A  98
LEU A 148
GLY A 138
ALA A 136
ALA A  29
 None
 1.16A 2bm9C-4nbqA:
undetectable		 2bm9C-4nbqA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 722
LEU A 757
GLY A 733
CYH A 783
ASN A 734
ALA A 780
 None
 1.34A 2bm9C-4oliA:
undetectable		 2bm9C-4oliA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF00171
(Aldedh) 		5 LEU A 204
LEU A 172
ASN A 124
ALA A 180
ALA A 184
 None
 1.16A 2bm9C-4ou2A:
3.1		 2bm9C-4ou2A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B

(Drosophila
melanogaster) 		PF00079
(Serpin) 		5 LEU A 270
GLU A 326
GLY A 327
ASN A 324
ALA A 330
 None
 1.12A 2bm9C-4p0fA:
undetectable		 2bm9C-4p0fA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Bacillus
anthracis) 		PF00588
(SpoU_methylase) 		5 LEU A   7
LEU A 136
GLY A  17
ALA A  20
ALA A  24
 None
SAH  A 201 ( 4.3A)
None
None
None
 1.18A 2bm9C-4pzkA:
undetectable		 2bm9C-4pzkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxf LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A  62
LEU A  55
GLU A  53
ALA A  76
ALA A 100
 None
 1.06A 2bm9C-4qxfA:
undetectable		 2bm9C-4qxfA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 LEU A  55
LEU A  59
GLY A  28
ASN A  40
ALA A  16
 None
 1.15A 2bm9C-4r16A:
4.5		 2bm9C-4r16A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3w 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 LEU A 199
LEU A 167
ASN A 119
ALA A 175
ALA A 179
 None
 1.14A 2bm9C-4u3wA:
undetectable		 2bm9C-4u3wA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uad IMPORTIN SUBUNIT
ALPHA-7

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 LEU A 206
GLY A 192
ASN A 236
ALA A 233
ALA A 230
 None
 1.10A 2bm9C-4uadA:
undetectable		 2bm9C-4uadA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wov NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 722
LEU A 757
GLY A 733
CYH A 783
ASN A 734
ALA A 780
 None
None
None
None
SO4  A 903 (-4.1A)
None
 1.36A 2bm9C-4wovA:
undetectable		 2bm9C-4wovA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A  21
GLY A  30
ASN A 117
ALA A  33
ALA A  37
 None
 1.10A 2bm9C-4wyrA:
undetectable		 2bm9C-4wyrA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg0 UNCHARACTERIZED
PROTEIN

(Bordetella
bronchiseptica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 LEU A 296
LEU A 324
GLY A 332
ALA A 331
ALA A 233
 None
 1.17A 2bm9C-4xg0A:
undetectable		 2bm9C-4xg0A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT ALPHA

(Yersinia
enterocolitica) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 LEU C 186
LEU C 512
GLU C 508
GLY C 505
ALA C 500
 None
 1.16A 2bm9C-4z42C:
undetectable		 2bm9C-4z42C:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A  32
LEU A  28
GLY A 358
ALA A 362
ALA A 410
 None
 1.05A 2bm9C-5bp1A:
undetectable		 2bm9C-5bp1A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8w ENDOGLUCANASE

(Ganoderma
lucidum) 		PF00150
(Cellulase) 		5 LEU A 104
LEU A  51
GLY A 312
ASN A 313
ALA A  30
 None
 1.10A 2bm9C-5d8wA:
undetectable		 2bm9C-5d8wA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtk BETAINE-ALDEHYDE
DEHYDROGENASE

(Bacillus cereus) 		PF00171
(Aldedh) 		5 LEU A 320
GLY A 287
ASN A 286
ALA A 284
ALA A 279
 None
 0.98A 2bm9C-5gtkA:
3.4		 2bm9C-5gtkA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwo PROBABLE PROTEIN
PHOSPHATASE 2C 50

(Oryza sativa) 		PF00481
(PP2C) 		5 LEU A 268
LEU A 279
GLY A 275
CYH A 129
ALA A 203
 None
 1.11A 2bm9C-5gwoA:
undetectable		 2bm9C-5gwoA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy0 GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 LEU A 319
LEU A 328
TYR A 364
ALA A 335
ALA A 338
 None
 1.05A 2bm9C-5gy0A:
undetectable		 2bm9C-5gy0A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		5 LEU A 968
LEU A 983
GLY A 958
ALA A 928
ALA A 926
 None
 1.13A 2bm9C-5irmA:
undetectable		 2bm9C-5irmA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		5 LEU A 569
LEU A 627
GLU A 632
GLY A 633
ALA A 606
 None
 1.09A 2bm9C-5jjhA:
undetectable		 2bm9C-5jjhA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		5 LEU A 528
LEU A 475
GLY A 555
ALA A 484
ALA A 488
 None
 0.92A 2bm9C-5kqiA:
undetectable		 2bm9C-5kqiA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyo CYP101J2

(Sphingobium
yanoikuyae) 		PF00067
(p450) 		5 LEU A 259
LEU A 160
GLY A 251
CYH A 359
ALA A 362
 None
None
HEM  A 501 (-3.3A)
HEM  A 501 (-2.4A)
None
 1.19A 2bm9C-5kyoA:
undetectable		 2bm9C-5kyoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 371
GLY A 381
ASN A 378
ALA A 211
ALA A 208
 None
 1.17A 2bm9C-5lnqA:
undetectable		 2bm9C-5lnqA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens) 		no annotation 5 LEU C 360
ASN C 337
CYH C 277
ASN C 382
ALA C 240
 None
None
None
SCY  C  88 ( 3.5A)
None
 1.09A 2bm9C-5mg5C:
undetectable		 2bm9C-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2

(Homo sapiens) 		no annotation 5 LEU A 349
GLU A 334
GLY A 308
ASN A 335
ALA A 307
 None
EDO  A 604 (-2.8A)
EDO  A 604 (-3.7A)
EDO  A 604 ( 4.3A)
EDO  A 605 ( 3.4A)
 1.15A 2bm9C-5ndfA:
undetectable		 2bm9C-5ndfA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ok8 LPP20 LIPOPROTEIN

(Helicobacter
pylori) 		no annotation 5 LEU A 137
GLY A  67
ASN A  92
ALA A  89
ALA A  85
 None
 1.11A 2bm9C-5ok8A:
undetectable		 2bm9C-5ok8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7o NOSK

(Streptomyces
actuosus) 		PF12697
(Abhydrolase_6) 		5 LEU A  64
LEU A 104
GLY A 100
ALA A 109
ALA A 113
 None
 1.15A 2bm9C-5v7oA:
2.6		 2bm9C-5v7oA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 5 LEU A 221
LEU A 256
GLY A 140
ALA A 232
ALA A 235
 None
 1.18A 2bm9C-5x9wA:
undetectable		 2bm9C-5x9wA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 5 LEU A 648
LEU A 634
GLY A 664
ASN A 312
ALA A 311
 None
 1.12A 2bm9C-5z06A:
undetectable		 2bm9C-5z06A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bn2 ACETYL-COA
ACETYLTRANSFERASE

(Elizabethkingia
anophelis) 		no annotation 5 LEU A  21
GLY A  30
ASN A 117
ALA A  33
ALA A  37
 None
 1.20A 2bm9C-6bn2A:
undetectable		 2bm9C-6bn2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP42

(Homo sapiens) 		no annotation 5 LEU E 192
GLY E  47
ASN E 162
ALA E 159
ALA E 155
 None
 1.02A 2bm9C-6d6qE:
undetectable		 2bm9C-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC6

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		5 LEU P 269
LEU P 265
ASN P 295
ALA O 497
ALA O 504
 None
 1.16A 2bm9C-6eu2P:
undetectable		 2bm9C-6eu2P:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 SER A 220
ASP A 255
ARG A 322
ASP A 319
 None
 1.44A 2bm9C-1asoA:
0.0		 2bm9C-1asoA:
17.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		4 SER A  95
ASP A 116
ARG A 117
ASP A 138
 SAM  A 301 (-3.0A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
 0.47A 2bm9C-2br4A:
34.5		 2bm9C-2br4A:
99.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		no annotation 4 SER E 352
ASP E 153
ARG E  81
ASP E  83
 None
 1.45A 2bm9C-3aoeE:
1.7		 2bm9C-3aoeE:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgu PROTEIN GIANT-LENS

(Drosophila
melanogaster) 		PF11581
(Argos) 		4 SER A 346
ASP A 274
ARG A 277
ASP A 126
 None
 1.44A 2bm9C-3cguA:
0.0		 2bm9C-3cguA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg9 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
OXIDOREDUCTASE
PROTEIN

(Ralstonia
solanacearum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 SER A  91
ASP A  99
ARG A  72
ASP A  76
 None
 1.45A 2bm9C-3gg9A:
4.1		 2bm9C-3gg9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 SER A 251
ASP A 203
ARG A 208
ASP A 207
 NAD  A 503 ( 4.4A)
NAD  A 503 (-2.8A)
NAD  A 503 (-4.0A)
None
 0.90A 2bm9C-3jv7A:
5.2		 2bm9C-3jv7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj9 ALCOHOL
DEHYDROGENASE

(Scaptodrosophila
lebanonensis) 		PF00106
(adh_short) 		4 SER A  22
ASP A  37
ARG A  38
ASP A  63
 None
NAD  A 850 (-2.7A)
None
NAD  A 850 (-3.3A)
 1.45A 2bm9C-3rj9A:
5.5		 2bm9C-3rj9A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a8j ELONGATOR COMPLEX
PROTEIN 5

(Saccharomyces
cerevisiae) 		PF10483
(Elong_Iki1) 		4 SER B 185
ASP B 172
ARG B 205
ASP B 219
 None
 1.23A 2bm9C-4a8jB:
2.9		 2bm9C-4a8jB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA

(Drosophila
melanogaster;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 SER R 206
ASP R 251
ARG R 299
ASP R 273
 None
 1.48A 2bm9C-4bv4R:
0.0		 2bm9C-4bv4R:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		4 SER V 147
ASP V 113
ARG V 110
ASP V 107
 None
CA  V2430 (-2.7A)
None
None
 1.30A 2bm9C-4bxsV:
undetectable		 2bm9C-4bxsV:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE

(Beutenbergia
cavernae) 		PF03372
(Exo_endo_phos) 		4 SER A 361
ASP A 302
ARG A 326
ASP A  52
 None
 1.20A 2bm9C-4ruwA:
undetectable		 2bm9C-4ruwA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE

(Escherichia
coli) 		PF06007
(PhnJ) 		4 SER D 249
ASP D 270
ARG D  97
ASP D 100
 None
 1.38A 2bm9C-4xb6D:
undetectable		 2bm9C-4xb6D:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 SER A 146
ASP A  94
ARG A 289
ASP A 259
 None
None
None
ATP  A 801 ( 4.9A)
 1.48A 2bm9C-5e84A:
undetectable		 2bm9C-5e84A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai TAIL FIBER PROTEIN

(Salmonella
virus P22) 		no annotation 4 SER Y 261
ASP Y 150
ARG Y 149
ASP Y 148
 None
 1.43A 2bm9C-5gaiY:
undetectable		 2bm9C-5gaiY:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1

(Escherichia
coli) 		PF00884
(Sulfatase) 		4 SER A 464
ASP A 366
ARG A 365
ASP A 404
 None
 1.46A 2bm9C-5k4pA:
undetectable		 2bm9C-5k4pA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o25 TMPDE

(Thermotoga
maritima) 		no annotation 4 SER A  32
ASP A 170
ARG A 166
ASP A 164
 None
 1.06A 2bm9C-5o25A:
undetectable		 2bm9C-5o25A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy3 -

(-) 		no annotation 4 SER A 258
ASP A 380
ARG A 167
ASP A 168
 None
 1.42A 2bm9C-5yy3A:
undetectable		 2bm9C-5yy3A:
undetectable