SIMILAR PATTERNS OF AMINO ACIDS FOR 2BM9_B_SAMB301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdb CIS-BIPHENYL-2,3-DIH
YDRODIOL-2,3-DEHYDRO
GENASE

(Pseudomonas sp.) 		PF00106
(adh_short) 		5 GLY A  12
ASP A  36
ARG A  41
ASP A  59
ASN A  86
 NAD  A 300 (-3.3A)
NAD  A 300 (-2.7A)
NAD  A 300 (-4.0A)
NAD  A 300 (-3.2A)
NAD  A 300 (-3.4A)
 1.09A 2bm9B-1bdbA:
5.1		 2bm9B-1bdbA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7g TYROSINE
PHENOL-LYASE

(Pantoea
agglomerans) 		PF01212
(Beta_elim_lyase) 		5 LEU A 427
LEU A 366
SER A 378
ARG A  21
ASP A  22
 None
 1.16A 2bm9B-1c7gA:
3.6		 2bm9B-1c7gA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE
PENICILLIN G AMIDASE

(Providencia
rettgeri;
Providencia
rettgeri) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		5 GLU B 398
GLY B 259
ASP B 262
ASN A 181
ALA B 250
 None
 1.28A 2bm9B-1cp9B:
undetectable		 2bm9B-1cp9B:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		5 LEU A 308
LEU A 271
GLY A 286
ASP A  18
ASP A 290
 None
 1.31A 2bm9B-1ituA:
undetectable		 2bm9B-1ituA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 LEU A 131
GLU A  98
SER A 157
ASP A  70
ALA A  83
 None
CEG  A 780 ( 4.9A)
None
None
None
 1.29A 2bm9B-1j0nA:
undetectable		 2bm9B-1j0nA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermotoga
maritima) 		PF00218
(IGPS) 		5 LEU A  84
LEU A 207
GLY A 155
ASN A 157
ALA A 110
 None
 1.32A 2bm9B-1j5tA:
undetectable		 2bm9B-1j5tA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0q SURFACE LAYER
PROTEIN

(Methanosarcina
mazei) 		PF00801
(PKD)
PF10282
(Lactonase) 		5 GLU A 210
GLY A 255
ASP A 254
ASN A 208
ALA A 250
 None
 1.33A 2bm9B-1l0qA:
undetectable		 2bm9B-1l0qA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qot CHITIN BINDING
LECTIN, UEA-II

(Ulex europaeus) 		PF00139
(Lectin_legB) 		5 LEU A 230
GLU A 166
GLY A 165
SER A 189
ASP A  80
 None
 1.29A 2bm9B-1qotA:
undetectable		 2bm9B-1qotA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rwr FILAMENTOUS
HEMAGGLUTININ

(Bordetella
pertussis) 		PF05860
(Haemagg_act) 		5 LEU A 273
LEU A 275
GLY A 264
SER A 282
ALA A 224
 None
 1.29A 2bm9B-1rwrA:
undetectable		 2bm9B-1rwrA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		5 LEU A 102
GLY A  45
SER A 109
ASP A  63
ALA A 172
 None
 1.19A 2bm9B-1upxA:
2.5		 2bm9B-1upxA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 GLY A  22
ARG A  47
ASP A  61
ASN A  88
ALA A 111
 NAP  A1249 (-3.2A)
NAP  A1249 (-3.6A)
NAP  A1249 (-3.7A)
None
NAP  A1249 (-3.6A)
 1.05A 2bm9B-1uznA:
4.9		 2bm9B-1uznA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 GLY B 329
ARG B  35
ASP B 286
ASN B 330
ALA B 291
 None
 1.24A 2bm9B-1wa5B:
undetectable		 2bm9B-1wa5B:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhl SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY MEMBER
(5L265), PUTATIVE
TROPINONE
REDUCTASE-II

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		5 GLY A  13
ARG A  38
ARG A  42
ASP A  66
ASN A  93
 NDP  A1278 (-3.1A)
NDP  A1278 (-3.6A)
NDP  A1278 (-2.8A)
NDP  A1278 (-3.4A)
NDP  A1278 (-3.9A)
 1.02A 2bm9B-1xhlA:
5.2		 2bm9B-1xhlA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		5 GLY A  13
ARG A  38
ARG A  42
ASP A  66
ASN A  93
 NDP  A1281 (-2.9A)
NDP  A1281 (-3.8A)
NDP  A1281 (-2.7A)
NDP  A1281 (-3.6A)
NDP  A1281 (-4.2A)
 1.05A 2bm9B-1xkqA:
5.3		 2bm9B-1xkqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI

(Homo sapiens) 		PF00106
(adh_short) 		5 GLY A  38
ASP A  62
ASP A  88
CYH A  89
ASN A 115
 CL  A 402 ( 3.7A)
CL  A 402 (-3.6A)
CL  A 405 ( 4.9A)
CL  A 405 (-4.6A)
SO4  A 702 ( 4.7A)
 1.14A 2bm9B-1yb1A:
4.8		 2bm9B-1yb1A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af4 PHOSPHATE
ACETYLTRANSFERASE

(Methanosarcina
thermophila) 		PF01515
(PTA_PTB) 		5 LEU C  30
LEU C  62
GLY C  48
ASP C 103
ALA C 108
 None
 1.24A 2bm9B-2af4C:
2.9		 2bm9B-2af4C:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 LEU A  68
GLU A  35
GLY A   7
ASP A 117
ALA A 109
 None
 1.32A 2bm9B-2afbA:
2.5		 2bm9B-2afbA:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		11 LEU A  18
LEU A  64
GLU A  87
GLY A  89
SER A  95
ASP A 116
ARG A 117
ARG A 121
ASP A 138
CYH A 139
ALA A 163
 SAM  A 301 ( 4.4A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.7A)
SAM  A 301 (-2.9A)
SAM  A 301 ( 3.7A)
 0.77A 2bm9B-2br4A:
33.8		 2bm9B-2br4A:
99.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7u ADENYLOSUCCINATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00709
(Adenylsucc_synt) 		5 LEU A 174
GLY A  17
SER A  24
ASP A  13
ALA A  41
 None
 1.32A 2bm9B-2d7uA:
undetectable		 2bm9B-2d7uA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 400
LEU A 370
GLY A 415
ASN A 417
ALA A 439
 None
 1.28A 2bm9B-2e6kA:
2.9		 2bm9B-2e6kA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewo PUTATIVE AGMATINE
DEIMINASE

(Streptococcus
mutans) 		PF04371
(PAD_porph) 		5 GLU A  22
GLY A 169
ASP A 168
ARG A 267
CYH A 204
 None
 1.30A 2bm9B-2ewoA:
undetectable		 2bm9B-2ewoA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 680
LEU A 607
GLY A 549
ASP A 550
ALA A 598
 None
 1.21A 2bm9B-2f3oA:
undetectable		 2bm9B-2f3oA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhe GLUTATHIONE
S-TRANSFERASE

(Fasciola
hepatica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 125
LEU A 164
GLY A 104
SER A 109
ALA A  97
 None
 1.24A 2bm9B-2fheA:
undetectable		 2bm9B-2fheA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K

(Homo sapiens) 		PF00481
(PP2C) 		5 LEU A 258
LEU A 269
GLY A 265
CYH A 138
ALA A 190
 None
 1.15A 2bm9B-2iq1A:
undetectable		 2bm9B-2iq1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0y GCN5-RELATED
N-ACETYLTRANSFERASE

(Cupriavidus
pinatubonensis) 		PF00583
(Acetyltransf_1) 		5 LEU A  47
LEU A  43
GLY A  68
ASN A  91
ALA A  65
 None
 1.27A 2bm9B-2q0yA:
undetectable		 2bm9B-2q0yA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 575
GLU A 791
GLY A 787
SER A 794
ALA A 776
 None
 1.30A 2bm9B-2qf7A:
4.2		 2bm9B-2qf7A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y93 CIS-2,3-DIHYDROBIPHE
NYL-2,3-DIOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF00106
(adh_short) 		5 GLY A  12
ASP A  36
ARG A  41
ASP A  59
ASN A  86
 None
 1.17A 2bm9B-2y93A:
5.2		 2bm9B-2y93A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 5 LEU A 195
LEU A 545
GLY A 163
ASP A 162
ALA A 229
 None
None
None
CA  A 634 (-2.9A)
None
 1.17A 2bm9B-2zuxA:
undetectable		 2bm9B-2zuxA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2

(Thermotoga
maritima;
synthetic
construct) 		PF00749
(tRNA-synt_1c)
PF02686
(Glu-tRNAGln) 		5 LEU C 440
LEU C 477
GLY C 429
ARG C 471
ASN C 428
 None
 1.30A 2bm9B-3al0C:
undetectable		 2bm9B-3al0C:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anp TRANSCRIPTIONAL
REPRESSOR, TETR
FAMILY

(Thermus
thermophilus) 		no annotation 5 LEU C 158
LEU C 161
GLU C 181
SER C 165
ARG C  87
 None
 1.31A 2bm9B-3anpC:
undetectable		 2bm9B-3anpC:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		5 LEU A 322
LEU A 326
GLU A 121
GLY A 149
ARG A 157
 None
None
HIU  A 502 (-2.9A)
None
None
 1.14A 2bm9B-3bptA:
undetectable		 2bm9B-3bptA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5y TRMH FAMILY RNA
METHYLTRANSFERASE

(Burkholderia
pseudomallei) 		PF00588
(SpoU_methylase) 		5 LEU A   6
LEU A 135
GLY A  16
ASN A  17
ALA A  23
 None
 1.19A 2bm9B-3e5yA:
3.1		 2bm9B-3e5yA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emi HIA (ADHESIN)

(Haemophilus
influenzae) 		PF15401
(TAA-Trp-ring) 		5 LEU A 331
GLY A 334
ASP A 353
ASN A 337
ALA A 346
 None
 1.08A 2bm9B-3emiA:
undetectable		 2bm9B-3emiA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE

(Thermus
thermophilus) 		PF00398
(RrnaAD) 		5 LEU A  91
LEU A  65
GLU A  52
GLY A  58
ALA A   5
 None
 1.32A 2bm9B-3futA:
8.8		 2bm9B-3futA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		5 LEU A1363
GLU A1220
GLY A1469
SER A1221
ASP A1467
 WW2  A 193 (-3.8A)
WW2  A 193 ( 4.2A)
None
WW2  A 193 (-1.4A)
None
 1.27A 2bm9B-3k9bA:
undetectable		 2bm9B-3k9bA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb3 PROTEIN PHOSPHATASE
2C 16

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 LEU B 394
LEU B 405
GLY B 401
CYH B 254
ALA B 329
 None
 1.14A 2bm9B-3kb3B:
undetectable		 2bm9B-3kb3B:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 LEU A 331
GLY A 318
CYH A 266
ASN A  54
ALA A 371
 None
 1.27A 2bm9B-3mduA:
undetectable		 2bm9B-3mduA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus) 		PF00079
(Serpin) 		5 LEU A 272
GLU A 326
GLY A 327
ASN A 324
ALA A 330
 None
 1.01A 2bm9B-3ndaA:
undetectable		 2bm9B-3ndaA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrw PHAGE
INTEGRASE/SITE-SPECI
FIC RECOMBINASE

(Haloarcula
marismortui) 		PF13102
(Phage_int_SAM_5) 		5 LEU A  36
LEU A  83
GLU A  88
ASN A  85
ALA A  24
 None
 1.23A 2bm9B-3nrwA:
undetectable		 2bm9B-3nrwA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 LEU B 289
GLU B 334
GLY B 314
ASP B 300
ALA B 281
 None
 1.31A 2bm9B-3pcoB:
undetectable		 2bm9B-3pcoB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgh RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 LEU A 204
ASP A 319
ARG A 200
CYH A 295
ALA A 299
 None
 1.30A 2bm9B-3qghA:
undetectable		 2bm9B-3qghA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj8 CARBOHYDRATE OXIDASE

(Microdochium
nivale) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A 183
LEU A 453
GLY A 191
ASN A 193
ALA A  65
 None
None
None
None
FAD  A 501 (-3.6A)
 1.05A 2bm9B-3rj8A:
undetectable		 2bm9B-3rj8A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF02854
(MIF4G) 		5 LEU A 243
LEU A 225
GLU A 223
GLY A 220
ALA A 214
 None
 1.04A 2bm9B-3rk6A:
undetectable		 2bm9B-3rk6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6k ACETYLGLUTAMATE
KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		5 LEU A  60
LEU A 123
GLY A  79
SER A 119
ALA A 198
 None
 1.27A 2bm9B-3s6kA:
3.7		 2bm9B-3s6kA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqz PUTATIVE
HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Streptococcus
mutans) 		PF00195
(Chal_sti_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A 134
LEU A  63
GLY A  57
ASP A  50
ASN A  60
 None
 1.20A 2bm9B-3sqzA:
undetectable		 2bm9B-3sqzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssm METHYLTRANSFERASE

(Micromonospora
griseorubida) 		no annotation 5 GLU A 202
GLY A 204
SER A 217
ASP A 234
ASP A 252
 SAH  A 601 (-3.4A)
SAH  A 601 (-3.5A)
SAH  A 601 (-3.2A)
SAH  A 601 (-2.8A)
SAH  A 601 (-3.6A)
 1.01A 2bm9B-3ssmA:
12.1		 2bm9B-3ssmA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA

(Pyrococcus
furiosus) 		PF09376
(NurA) 		5 LEU A 292
LEU A 129
GLU A 102
SER A 132
ALA A  71
 None
None
GOL  A 454 (-4.0A)
None
None
 1.30A 2bm9B-3talA:
undetectable		 2bm9B-3talA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue9 ADENYLOSUCCINATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF00709
(Adenylsucc_synt) 		5 LEU A  33
GLU A 231
GLY A 232
ASP A 239
ALA A 257
 None
 1.33A 2bm9B-3ue9A:
undetectable		 2bm9B-3ue9A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3

(Desulfovibrio
vulgaris) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF16658
(RF3_C) 		5 LEU A  32
LEU A 267
GLU A 265
GLY A 262
ASP A 144
 None
None
None
None
G4P  A 601 (-2.9A)
 1.20A 2bm9B-3vr1A:
undetectable		 2bm9B-3vr1A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6j PHOSPHOSERINE
PHOSPHATASE

(Thermococcus
onnurineus) 		PF12710
(HAD) 		5 LEU A  80
LEU A  13
GLY A 150
ASP A 176
ALA A 162
 None
 1.13A 2bm9B-4b6jA:
2.6		 2bm9B-4b6jA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ber PHOSPHOCHOLINE
TRANSFERASE ANKX

(Legionella
pneumophila) 		PF02661
(Fic)
PF12796
(Ank_2) 		5 LEU A 194
LEU A 228
GLU A 226
CYH A  84
ASN A 235
 None
None
PO4  A2000 (-3.4A)
None
None
 1.31A 2bm9B-4berA:
undetectable		 2bm9B-4berA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE

(Trypanosoma
brucei) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A  48
LEU A  51
GLY A 146
SER A  55
ARG A 115
 None
 1.32A 2bm9B-4bi9A:
undetectable		 2bm9B-4bi9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		5 LEU A 191
LEU A 146
GLY A 182
ASP A 185
ASN A 118
 None
 1.29A 2bm9B-4cczA:
undetectable		 2bm9B-4cczA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL

(Homo sapiens) 		PF00481
(PP2C) 		5 LEU A 258
LEU A 269
GLY A 265
CYH A 138
ALA A 190
 None
 1.23A 2bm9B-4da1A:
undetectable		 2bm9B-4da1A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0l AMIDOHYDROLASE

(Brucella
abortus) 		PF01979
(Amidohydro_1) 		5 LEU A 336
GLY A 323
CYH A 271
ASN A  59
ALA A 375
 None
 1.28A 2bm9B-4f0lA:
undetectable		 2bm9B-4f0lA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 LEU A  34
LEU A   4
GLY A  54
ASN A  24
ALA A 103
 None
 1.29A 2bm9B-4fzwA:
undetectable		 2bm9B-4fzwA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Mycolicibacterium
thermoresistibile) 		PF16113
(ECH_2) 		5 LEU A 282
LEU A 286
GLU A  91
GLY A 119
ARG A 127
 None
 1.23A 2bm9B-4hdtA:
undetectable		 2bm9B-4hdtA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594

(Pyrococcus
horikoshii) 		PF00326
(Peptidase_S9)
PF07676
(PD40) 		5 LEU B 538
LEU B 476
GLY B 469
ASP B 546
CYH B 549
 None
None
None
None
HEZ  B 709 ( 3.8A)
 1.23A 2bm9B-4hxeB:
undetectable		 2bm9B-4hxeB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg2 PHAGE-RELATED
PROTEIN

(Bacillus cereus) 		PF10991
(DUF2815) 		5 LEU A  81
GLU A  87
GLY A  84
ASP A  85
ALA A  92
 None
 1.03A 2bm9B-4jg2A:
undetectable		 2bm9B-4jg2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		5 LEU A  64
GLY A  70
ARG A  75
ASN A  67
ALA A 439
 None
 1.18A 2bm9B-4k70A:
undetectable		 2bm9B-4k70A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Oncorhynchus
mykiss) 		PF00079
(Serpin) 		5 LEU A 269
GLU A 325
GLY A 326
ASN A 323
ALA A 329
 None
 1.06A 2bm9B-4kdsA:
undetectable		 2bm9B-4kdsA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 LEU A 327
LEU A 337
GLY A 127
SER A 314
ASP A 122
 None
 1.02A 2bm9B-4kg7A:
undetectable		 2bm9B-4kg7A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLY A 344
SER A 359
ASP A 347
ARG A 350
ALA A 328
 None
 1.10A 2bm9B-4mkvA:
undetectable		 2bm9B-4mkvA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0g PROTEIN PHOSPHATASE
2C 37

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 LEU A 289
LEU A 300
GLY A 296
CYH A 153
ALA A 224
 None
 1.24A 2bm9B-4n0gA:
undetectable		 2bm9B-4n0gA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8g TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		5 LEU A 289
LEU A 233
ARG A 281
ASP A 277
ALA A  45
 None
 1.18A 2bm9B-4n8gA:
undetectable		 2bm9B-4n8gA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 652
LEU A 666
GLY A 766
ASP A 764
ASP A 750
 None
 1.03A 2bm9B-4otdA:
undetectable		 2bm9B-4otdA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER

(Marinomonas
primoryensis) 		no annotation 5 GLU A 364
GLY A 363
ASP A 392
ASN A 362
ALA A 390
 None
None
None
None
CA  A 505 (-4.7A)
 1.08A 2bm9B-4p99A:
undetectable		 2bm9B-4p99A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		5 GLU B 398
GLY B 259
ASP B 262
ASN A 183
ALA B 250
 None
 1.18A 2bm9B-4pelB:
undetectable		 2bm9B-4pelB:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puf E3 UBIQUITIN-PROTEIN
LIGASE SLRP

(Salmonella
enterica) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		5 LEU A 340
LEU A 319
GLY A 333
ASP A 352
ASN A 335
 None
 1.31A 2bm9B-4pufA:
undetectable		 2bm9B-4pufA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puf E3 UBIQUITIN-PROTEIN
LIGASE SLRP

(Salmonella
enterica) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		5 LEU A 588
LEU A 624
GLY A 613
ASP A 606
ASN A 616
 None
 1.12A 2bm9B-4pufA:
undetectable		 2bm9B-4pufA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 GLY A 588
ASP A 589
ASP A 545
ASN A 613
ALA A 666
 None
None
ZN  A1901 (-3.4A)
None
None
 1.04A 2bm9B-4r04A:
undetectable		 2bm9B-4r04A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Staphylococcus
aureus) 		PF01380
(SIS) 		5 GLU A 532
GLY A 528
ASP A 553
ASN A 529
ALA A 517
 None
 1.23A 2bm9B-4s1wA:
2.3		 2bm9B-4s1wA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE

(Escherichia
coli) 		PF06007
(PhnJ) 		5 GLU D 112
SER D 249
ASP D 270
ARG D  97
ASP D 100
 None
 1.33A 2bm9B-4xb6D:
undetectable		 2bm9B-4xb6D:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9k VHH2(F5) ANTIBODY

(Vicugna pacos) 		PF07686
(V-set) 		5 GLY B  47
SER B  61
ARG B  45
ASP B 105
ALA B  93
 None
 1.31A 2bm9B-4z9kB:
undetectable		 2bm9B-4z9kB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum) 		PF02055
(Glyco_hydro_30) 		5 LEU A 233
GLY A 271
ASP A 268
CYH A  27
ALA A  25
 CL  A 615 ( 4.1A)
None
None
None
None
 1.29A 2bm9B-5cxpA:
undetectable		 2bm9B-5cxpA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 LEU A 169
LEU A 283
GLY A 157
ASP A 159
ALA A   8
 None
 1.28A 2bm9B-5eowA:
2.9		 2bm9B-5eowA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 LEU h 189
GLY h 217
ARG h 325
ASP h 322
ASN h 216
 None
 1.22A 2bm9B-5gw5h:
undetectable		 2bm9B-5gw5h:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwo PROBABLE PROTEIN
PHOSPHATASE 2C 50

(Oryza sativa) 		PF00481
(PP2C) 		5 LEU A 268
LEU A 279
GLY A 275
CYH A 129
ALA A 203
 None
 1.12A 2bm9B-5gwoA:
undetectable		 2bm9B-5gwoA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		PF00106
(adh_short) 		5 GLY A  13
ASP A  37
ARG A 200
ASP A  63
ASN A  90
 NAD  A 301 (-3.4A)
NAD  A 301 (-2.9A)
NAD  A 301 (-3.2A)
NAD  A 301 (-3.7A)
NAD  A 301 (-3.3A)
 1.12A 2bm9B-5ig2A:
6.0		 2bm9B-5ig2A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itw DIHYDROANTICAPSIN
7-DEHYDROGENASE

(Bacillus
subtilis) 		PF13561
(adh_short_C2) 		5 LEU A 191
GLY A  14
ASP A  38
ASP A  62
ASN A  89
 SO4  A 302 ( 4.8A)
None
None
None
SO4  A 302 (-3.3A)
 0.95A 2bm9B-5itwA:
5.8		 2bm9B-5itwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		5 LEU A 569
LEU A 627
GLU A 632
GLY A 633
ALA A 606
 None
 1.10A 2bm9B-5jjhA:
undetectable		 2bm9B-5jjhA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo9 RIBITOL
2-DEHYDROGENASE

(Bradyrhizobium
japonicum) 		PF00106
(adh_short) 		5 LEU A 190
GLY A  14
ASP A  38
ASP A  61
ASN A  88
 PO4  A 301 (-4.4A)
PO4  A 301 (-4.5A)
None
None
PO4  A 301 (-3.4A)
 1.05A 2bm9B-5jo9A:
6.2		 2bm9B-5jo9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koj NITROGENASE PROTEIN
ALPHA CHAIN

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro) 		5 GLY A 398
SER A 206
ASP A 402
ARG A 405
ASN A  65
 None
 1.22A 2bm9B-5kojA:
undetectable		 2bm9B-5kojA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1t MUCR
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		5 LEU A 539
GLU A 502
GLY A 501
SER A 542
ALA A 491
 None
 0.99A 2bm9B-5m1tA:
undetectable		 2bm9B-5m1tA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mln ALCOHOL
DEHYDROGENASE 3

([Candida]
magnoliae) 		no annotation 5 GLY A  11
SER A  20
ARG A  36
ASP A  63
ASN A  89
 NAP  A 301 (-3.2A)
None
NAP  A 301 (-3.5A)
NAP  A 301 (-4.0A)
NAP  A 301 (-3.2A)
 1.32A 2bm9B-5mlnA:
5.0		 2bm9B-5mlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mua RICIN B-RELATED
LECTIN

(Polyporus
squamosus) 		PF14200
(RicinB_lectin_2) 		5 LEU A 182
GLU A 225
GLY A 223
ASN A 226
ALA A 229
 None
 1.23A 2bm9B-5muaA:
undetectable		 2bm9B-5muaA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 GLY A  12
ARG A  37
ARG A  41
ASP A  59
ASN A  82
 NAP  A 301 (-3.3A)
NAP  A 301 (-3.5A)
NAP  A 301 (-3.0A)
NAP  A 301 (-3.8A)
NAP  A 301 (-3.4A)
 0.90A 2bm9B-5t2uA:
5.2		 2bm9B-5t2uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 GLY A  12
SER A  21
ARG A  37
ASP A  59
ASN A  82
 NAP  A 301 (-3.3A)
None
NAP  A 301 (-3.5A)
NAP  A 301 (-3.8A)
NAP  A 301 (-3.4A)
 1.34A 2bm9B-5t2uA:
5.2		 2bm9B-5t2uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens) 		no annotation 5 LEU B 121
LEU B  42
GLU B  40
GLY B  36
ALA B 173
 None
 1.18A 2bm9B-5thzB:
7.8		 2bm9B-5thzB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		5 LEU A  62
GLY A 193
SER A 227
ASN A  57
ALA A 184
 None
None
None
7SG  A 402 (-4.0A)
None
 0.97A 2bm9B-5u24A:
2.3		 2bm9B-5u24A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm1 XYLULOKINASE

(Brucella ovis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 157
LEU A 161
GLY A   4
ASP A 422
ALA A  26
 None
 1.29A 2bm9B-5vm1A:
undetectable		 2bm9B-5vm1A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		5 GLY A  12
ASP A  36
ARG A  37
ASP A  60
ASN A  87
 NAD  A 301 (-3.3A)
NAD  A 301 (-2.8A)
NAD  A 301 (-4.3A)
NAD  A 301 (-3.7A)
NAD  A 301 (-3.3A)
 0.88A 2bm9B-5vn2A:
5.6		 2bm9B-5vn2A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6acd -

(-) 		no annotation 5 LEU A 986
LEU A 944
GLY A 839
ASP A 719
ASN A 838
 None
 1.14A 2bm9B-6acdA:
undetectable		 2bm9B-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9u DNA GYRASE, SUBUNIT
B:SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
abortus) 		no annotation 5 LEU A 194
GLY A  13
ASP A  37
ARG A  38
ASP A  60
 NAI  A 301 (-3.3A)
NAI  A 301 (-3.1A)
NAI  A 301 (-2.8A)
NAI  A 301 (-3.4A)
NAI  A 301 (-3.4A)
 1.25A 2bm9B-6b9uA:
5.3		 2bm9B-6b9uA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9u DNA GYRASE, SUBUNIT
B:SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
abortus) 		no annotation 5 LEU A 194
GLY A  13
ASP A  37
ASP A  60
ASN A  87
 NAI  A 301 (-3.3A)
NAI  A 301 (-3.1A)
NAI  A 301 (-2.8A)
NAI  A 301 (-3.4A)
NAI  A 301 (-3.3A)
 1.24A 2bm9B-6b9uA:
5.3		 2bm9B-6b9uA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 5 GLY A 150
SER A 101
ASP A 151
ARG A 157
ASP A 156
 None
 1.28A 2bm9B-6bs7A:
undetectable		 2bm9B-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 5 LEU A 108
SER A  92
ARG A  70
ASP A  80
ALA A  74
 None
 1.20A 2bm9B-6c01A:
undetectable		 2bm9B-6c01A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1

(Homo sapiens) 		no annotation 5 LEU A 550
GLU A1095
GLY A1091
ASN A 555
ALA A 562
 None
 1.32A 2bm9B-6d4jA:
undetectable		 2bm9B-6d4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8y THREONYLCARBAMOYL-AM
P SYNTHASE

(Pyrococcus
abyssi) 		no annotation 5 LEU A 296
LEU A 285
GLU A 314
GLY A 315
ARG A 330
 None
 1.29A 2bm9B-6f8yA:
undetectable		 2bm9B-6f8yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 5 LEU A 436
LEU A 395
GLY A 366
CYH A 273
ALA A 471
 None
 1.34A 2bm9B-6fyvA:
undetectable		 2bm9B-6fyvA:
undetectable