SIMILAR PATTERNS OF AMINO ACIDS FOR 2BM9_A_SAMA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)

(Trypanosoma
cruzi) 		PF00155
(Aminotran_1_2) 		5 LEU A 262
GLU A  79
GLY A 300
SER A  77
ALA A  54
 None
 1.10A 2bm9A-1bw0A:
3.7		 2bm9A-1bw0A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		5 GLU A 248
GLY A 250
SER A 335
ARG A  74
ALA A 216
 None
 1.14A 2bm9A-1fpsA:
undetectable		 2bm9A-1fpsA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h21 SPLIT-SORET
CYTOCHROME C

(Desulfovibrio
desulfuricans) 		PF09719
(C_GCAxxG_C_C) 		5 LEU A 137
GLY A 132
ASP A  35
ALA A 130
ALA A 129
 None
 1.14A 2bm9A-1h21A:
undetectable		 2bm9A-1h21A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 LEU A 157
LEU A 166
GLY A  71
ALA A  87
ALA A 123
 None
 1.13A 2bm9A-1i7oA:
undetectable		 2bm9A-1i7oA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		5 LEU A 273
GLY A 268
ASP A 500
ALA A 264
ALA A 260
 None
 1.12A 2bm9A-1iduA:
undetectable		 2bm9A-1iduA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 LEU A 695
ARG A 615
ASP A 612
ALA A 754
ALA A 762
 None
 1.06A 2bm9A-1ileA:
undetectable		 2bm9A-1ileA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		5 LEU A 511
LEU A 458
GLY A 538
ALA A 467
ALA A 471
 None
 0.96A 2bm9A-1itkA:
undetectable		 2bm9A-1itkA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		5 LEU A  65
GLU A 211
GLY A   7
ALA A  39
ALA A  37
 None
 1.14A 2bm9A-1ixpA:
undetectable		 2bm9A-1ixpA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 LEU A 131
GLU A  98
SER A 157
ASP A  70
ALA A  83
 None
CEG  A 780 ( 4.9A)
None
None
None
 1.13A 2bm9A-1j0nA:
undetectable		 2bm9A-1j0nA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II

(Thermus
thermophilus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A  83
LEU A  93
GLY A 149
ALA A 145
ALA A 142
 None
 1.16A 2bm9A-1j3nA:
undetectable		 2bm9A-1j3nA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr1 HEVAMINE A

(Hevea
brasiliensis) 		PF00704
(Glyco_hydro_18) 		5 LEU A 137
LEU A  87
GLY A  79
ALA A 125
ALA A 156
 None
None
None
NAG  A 904 (-3.6A)
NAG  A 904 ( 4.2A)
 1.04A 2bm9A-1kr1A:
undetectable		 2bm9A-1kr1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		5 LEU A  68
LEU A 214
GLY A  82
TYR A 227
ARG A 240
 None
 1.06A 2bm9A-1lc7A:
4.2		 2bm9A-1lc7A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc3 PHOSPHATE-BINDING
PROTEIN 1

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		5 LEU A 309
LEU A  30
GLY A  80
ALA A  72
ALA A  73
 None
 0.92A 2bm9A-1pc3A:
undetectable		 2bm9A-1pc3A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR

(Homo sapiens) 		PF02089
(Palm_thioest) 		5 LEU A 115
LEU A  83
TYR A 178
ASP A 185
ALA A 196
 None
 1.07A 2bm9A-1pjaA:
3.9		 2bm9A-1pjaA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rwr FILAMENTOUS
HEMAGGLUTININ

(Bordetella
pertussis) 		PF05860
(Haemagg_act) 		5 LEU A 273
LEU A 275
GLY A 264
SER A 282
ALA A 224
 None
 1.05A 2bm9A-1rwrA:
undetectable		 2bm9A-1rwrA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		5 LEU A  79
LEU A 479
GLY A  25
SER A 481
ALA A  48
 None
 1.15A 2bm9A-1sezA:
2.2		 2bm9A-1sezA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqi 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE

(Rattus
norvegicus) 		PF00903
(Glyoxalase) 		5 LEU A  50
SER A  54
ASP A  91
ALA A  29
ALA A  32
 None
 1.07A 2bm9A-1sqiA:
undetectable		 2bm9A-1sqiA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1)
PF13177
(DNA_pol3_delta2) 		5 GLU E 343
GLY E 344
ARG E 331
CYH E 351
ALA A 615
 None
 1.14A 2bm9A-1sxjE:
undetectable		 2bm9A-1sxjE:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		5 LEU A 102
GLY A  45
SER A 109
ASP A  63
ALA A 172
 None
 1.01A 2bm9A-1upxA:
2.7		 2bm9A-1upxA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		5 LEU A 102
LEU A 108
GLY A  45
ASP A  63
ALA A 172
 None
 1.13A 2bm9A-1upxA:
2.7		 2bm9A-1upxA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwu HYPOTHETICAL PROTEIN
FLJ21935

(Homo sapiens) 		no annotation 5 LEU A  54
LEU A  33
GLU A  69
GLY A  70
SER A  39
 None
 1.05A 2bm9A-1wwuA:
undetectable		 2bm9A-1wwuA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 LEU A 342
LEU A 340
GLY A 387
TYR A 329
ALA A  87
 None
 1.04A 2bm9A-1xc6A:
undetectable		 2bm9A-1xc6A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhl SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY MEMBER
(5L265), PUTATIVE
TROPINONE
REDUCTASE-II

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		5 GLY A  13
ARG A  38
ARG A  42
ASP A  66
ALA A  94
 NDP  A1278 (-3.1A)
NDP  A1278 (-3.6A)
NDP  A1278 (-2.8A)
NDP  A1278 (-3.4A)
NDP  A1278 (-3.9A)
 0.88A 2bm9A-1xhlA:
2.5		 2bm9A-1xhlA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 125
GLU A  34
GLY A  11
ALA A 145
ALA A 307
 None
FAD  A 666 (-2.5A)
FAD  A 666 (-3.2A)
FAD  A 666 (-4.9A)
None
 1.06A 2bm9A-1zk7A:
4.1		 2bm9A-1zk7A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE

(Pseudomonas
putida;
Spinacia
oleracea) 		PF01070
(FMN_dh) 		5 LEU A 326
LEU A 306
ASP A 123
CYH A 122
ALA A  95
 None
 1.12A 2bm9A-2a7nA:
undetectable		 2bm9A-2a7nA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af4 PHOSPHATE
ACETYLTRANSFERASE

(Methanosarcina
thermophila) 		PF01515
(PTA_PTB) 		5 LEU C  30
LEU C  62
GLY C  48
ASP C 103
ALA C 108
 None
 1.17A 2bm9A-2af4C:
3.4		 2bm9A-2af4C:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		10 GLU A  87
GLY A  89
TYR A  91
SER A  95
ARG A 117
ARG A 121
ASP A 138
CYH A 139
ALA A 161
ALA A 163
 SAM  A 301 (-3.0A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.7A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.6A)
SAM  A 301 ( 3.7A)
 0.78A 2bm9A-2br4A:
34.4		 2bm9A-2br4A:
99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		11 LEU A  18
LEU A  64
GLU A  87
GLY A  89
TYR A  91
SER A  95
ARG A 121
ASP A 138
CYH A 139
ALA A 161
ALA A 163
 SAM  A 301 ( 4.4A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.7A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.6A)
SAM  A 301 ( 3.7A)
 0.65A 2bm9A-2br4A:
34.4		 2bm9A-2br4A:
99.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cmh SPERMIDINE SYNTHASE

(Helicobacter
pylori) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 LEU A  62
GLY A 209
SER A 206
ALA A 171
ALA A 184
 None
 1.12A 2bm9A-2cmhA:
7.9		 2bm9A-2cmhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g17 N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Salmonella
enterica) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A  52
GLY A  11
ARG A 237
ALA A  13
ALA A 313
 None
SO4  A 405 (-3.1A)
None
SO4  A 405 (-3.7A)
None
 1.15A 2bm9A-2g17A:
4.0		 2bm9A-2g17A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K

(Homo sapiens) 		PF00481
(PP2C) 		5 LEU A 258
LEU A 269
GLY A 265
CYH A 138
ALA A 190
 None
 1.17A 2bm9A-2iq1A:
undetectable		 2bm9A-2iq1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		5 LEU A 730
LEU A 737
CYH A 644
ALA A 707
ALA A 636
 None
 0.96A 2bm9A-2rdyA:
undetectable		 2bm9A-2rdyA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rek PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 LEU A  74
LEU A 132
GLY A 102
ARG A  70
ALA A  99
 None
 1.11A 2bm9A-2rekA:
undetectable		 2bm9A-2rekA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		5 LEU A 174
LEU A  90
GLY A  83
ALA A 113
ALA A 117
 None
None
SFD  A1418 ( 4.3A)
SFD  A1418 (-3.5A)
SFD  A1418 (-3.2A)
 1.11A 2bm9A-2vfvA:
undetectable		 2bm9A-2vfvA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		5 LEU A 308
LEU A 317
TYR A 354
ALA A 324
ALA A 327
 None
 1.12A 2bm9A-2xfgA:
undetectable		 2bm9A-2xfgA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		5 LEU A 381
LEU A 394
GLU A 407
ALA A 352
ALA A 663
 None
 1.10A 2bm9A-2xsgA:
undetectable		 2bm9A-2xsgA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 LEU A 389
GLU A  94
GLY A  63
ALA A 409
ALA A 650
 None
FAD  A 801 (-2.7A)
FAD  A 801 (-3.1A)
None
None
 1.16A 2bm9A-2yr5A:
3.3		 2bm9A-2yr5A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 LEU A 389
GLY A  63
TYR A  93
ALA A 409
ALA A 650
 None
FAD  A 801 (-3.1A)
None
None
None
 0.90A 2bm9A-2yr5A:
3.3		 2bm9A-2yr5A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350

(Thermus
thermophilus) 		PF00582
(Usp) 		5 LEU A 228
LEU A 238
GLY A 241
ALA A 167
ALA A 163
 LEU  A 228 ( 0.6A)
LEU  A 238 ( 0.6A)
GLY  A 241 ( 0.0A)
ALA  A 167 ( 0.0A)
ALA  A 163 ( 0.0A)
 1.09A 2bm9A-3ab7A:
2.8		 2bm9A-3ab7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 LEU A 562
LEU A 445
ASP A 547
ALA A 437
ALA A 406
 None
 1.15A 2bm9A-3b9eA:
2.2		 2bm9A-3b9eA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		5 LEU A 322
LEU A 326
GLU A 121
GLY A 149
ARG A 157
 None
None
HIU  A 502 (-2.9A)
None
None
 1.12A 2bm9A-3bptA:
undetectable		 2bm9A-3bptA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		5 LEU A 183
LEU A 122
GLY A 115
ASP A 140
ALA A 148
 None
 1.03A 2bm9A-3cwcA:
2.0		 2bm9A-3cwcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnh UNCHARACTERIZED
PROTEIN ATU2129

(Agrobacterium
fabrum) 		PF13883
(Pyrid_oxidase_2) 		5 LEU A 107
LEU A 147
GLU A  62
GLY A  65
ASP A 220
 None
 1.06A 2bm9A-3dnhA:
undetectable		 2bm9A-3dnhA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		5 LEU A  10
GLY A  19
SER A 121
ALA A 167
ALA A 304
 None
 1.09A 2bm9A-3e1tA:
undetectable		 2bm9A-3e1tA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k33 DEATH ON CURING
PROTEIN

(Escherichia
virus P1) 		PF02661
(Fic) 		5 LEU A   9
GLY A  65
SER A  27
ALA A  63
ALA A 104
 None
 0.95A 2bm9A-3k33A:
undetectable		 2bm9A-3k33A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb3 PROTEIN PHOSPHATASE
2C 16

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 LEU B 394
LEU B 405
GLY B 401
CYH B 254
ALA B 329
 None
 1.17A 2bm9A-3kb3B:
undetectable		 2bm9A-3kb3B:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf2 SHORT CHAIN
OXIDOREDUCTASE
Q9HYA2

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		5 GLY A  15
ARG A  40
ARG A  44
ASP A  67
ALA A  95
 NDP  A 301 (-3.2A)
NDP  A 301 (-3.7A)
NDP  A 301 (-3.9A)
NDP  A 301 (-3.6A)
NDP  A 301 (-3.6A)
 0.95A 2bm9A-3lf2A:
7.2		 2bm9A-3lf2A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		5 LEU A 335
LEU A 339
GLY A 321
ALA A 294
ALA A 273
 None
 1.04A 2bm9A-3lscA:
undetectable		 2bm9A-3lscA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		5 LEU A 659
LEU A 607
ARG A 591
ALA A 485
ALA A 484
 None
 1.17A 2bm9A-3lvvA:
undetectable		 2bm9A-3lvvA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		5 LEU A 277
LEU A  48
TYR A 204
ALA A 191
ALA A 196
 None
 1.07A 2bm9A-3m0gA:
undetectable		 2bm9A-3m0gA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus) 		PF00079
(Serpin) 		5 LEU A 164
LEU A 106
GLY A  47
SER A 109
ALA A 300
 None
 1.13A 2bm9A-3ndaA:
undetectable		 2bm9A-3ndaA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 LEU A 294
GLU A  34
GLY A   9
ALA A 285
ALA A 447
 None
FAD  A 479 (-3.0A)
FAD  A 479 (-3.3A)
None
None
 0.98A 2bm9A-3nksA:
2.4		 2bm9A-3nksA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmn HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Vibrio cholerae) 		PF01648
(ACPS) 		5 LEU A  31
GLY A  46
SER A  42
ALA A  50
ALA A  10
 None
None
CL  A 128 ( 4.6A)
None
MPD  A2570 (-3.6A)
 0.94A 2bm9A-3qmnA:
undetectable		 2bm9A-3qmnA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF02854
(MIF4G) 		5 LEU A 243
LEU A 225
GLU A 223
GLY A 220
ALA A 214
 None
 1.08A 2bm9A-3rk6A:
undetectable		 2bm9A-3rk6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue1 PENICILLIN-BINDING
PROTEIN 1A

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 LEU A 253
GLU A 247
GLY A 246
SER A 251
ALA A  40
 None
 1.11A 2bm9A-3ue1A:
undetectable		 2bm9A-3ue1A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		5 LEU A 564
LEU A 511
GLY A 590
ALA A 520
ALA A 524
 None
 0.95A 2bm9A-3ut2A:
undetectable		 2bm9A-3ut2A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9w MONOOXYGENASE

(Stenotrophomonas
maltophilia) 		PF13738
(Pyr_redox_3) 		5 LEU A 309
LEU A 320
GLY A 335
SER A  17
ALA A 329
 None
 1.10A 2bm9A-4a9wA:
2.5		 2bm9A-4a9wA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		5 LEU A 230
LEU A 110
GLY A  69
TYR A  67
ALA A 181
 None
 1.03A 2bm9A-4c1oA:
undetectable		 2bm9A-4c1oA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 LEU A 521
LEU A 467
GLY A 548
ALA A 476
ALA A 480
 None
 0.93A 2bm9A-4c51A:
undetectable		 2bm9A-4c51A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 LEU A   3
LEU A 366
GLY A 423
ALA A 361
ALA A 359
 None
 1.11A 2bm9A-4cakA:
undetectable		 2bm9A-4cakA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		5 LEU A 328
LEU A 337
TYR A 374
ALA A 344
ALA A 347
 None
 1.09A 2bm9A-4doeA:
undetectable		 2bm9A-4doeA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egj D-ALANINE--D-ALANINE
LIGASE

(Paraburkholderia
xenovorans) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 LEU A 265
LEU A 234
TYR A 193
ALA A 246
ALA A 249
 None
 1.06A 2bm9A-4egjA:
2.4		 2bm9A-4egjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		5 GLU A 279
GLY A 275
TYR A 125
ARG A 124
ALA A 218
 None
 1.02A 2bm9A-4hpvA:
undetectable		 2bm9A-4hpvA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN

(Pseudomonas;
Pseudomonas) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		5 LEU A 142
LEU B 427
GLU A  86
GLY A  84
ASP B 113
 None
 1.13A 2bm9A-4hstA:
undetectable		 2bm9A-4hstA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN

(Pseudomonas;
Pseudomonas) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		5 LEU A 142
LEU B 427
GLY A  84
ASP B 113
ALA A  80
 None
 1.01A 2bm9A-4hstA:
undetectable		 2bm9A-4hstA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 LEU A 277
LEU A  47
TYR A 204
ALA A 191
ALA A 196
 None
 1.15A 2bm9A-4llsA:
undetectable		 2bm9A-4llsA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A 215
TYR A 132
CYH A 110
ALA A 259
ALA A 114
 None
 1.02A 2bm9A-4oqjA:
undetectable		 2bm9A-4oqjA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		5 LEU A  70
LEU A 200
GLY A 231
ASP A 240
ALA A 229
 None
 1.15A 2bm9A-4r5zA:
3.5		 2bm9A-4r5zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		5 LEU A  30
LEU A  59
GLY A  80
ALA A  84
ALA A  87
 None
 1.11A 2bm9A-4rncA:
2.8		 2bm9A-4rncA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Neisseria
meningitidis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 285
LEU A  13
GLU A  50
ASP A 109
ALA A  56
 None
 1.06A 2bm9A-4rybA:
undetectable		 2bm9A-4rybA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upk PHOSPHONATE
MONOESTER HYDROLASE

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		6 LEU A 481
GLU A 442
SER A 477
ASP A 407
ALA A 444
ALA A 427
 None
 1.37A 2bm9A-4upkA:
undetectable		 2bm9A-4upkA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 LEU A 371
GLU A 345
GLY A 344
SER A 349
ALA A 381
 None
 1.07A 2bm9A-4xgjA:
2.5		 2bm9A-4xgjA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		5 LEU A 192
GLU A  34
GLY A  11
ALA A 207
ALA A 331
 None
FAD  A 401 (-2.7A)
FAD  A 401 (-3.3A)
None
None
 1.17A 2bm9A-4yshA:
2.9		 2bm9A-4yshA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3k SEPIAPTERIN
REDUCTASE

(Homo sapiens) 		PF00106
(adh_short) 		5 GLY A  11
ARG A  39
ARG A  14
ASP A  66
ALA A  98
 NAP  A 801 (-3.2A)
SO4  A 803 ( 2.7A)
NAP  A 801 (-3.8A)
NAP  A 801 (-3.8A)
NAP  A 801 (-3.8A)
 1.10A 2bm9A-4z3kA:
6.9		 2bm9A-4z3kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg8 ENDOGLUCANASE

(Perinereis
brevicirris) 		PF00759
(Glyco_hydro_9) 		5 LEU A 297
LEU A 306
TYR A 339
ALA A 313
ALA A 316
 None
 1.09A 2bm9A-4zg8A:
undetectable		 2bm9A-4zg8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A 284
GLU A 339
GLY A 340
ALA A 341
ALA A 343
 None
 1.12A 2bm9A-4zk3A:
undetectable		 2bm9A-4zk3A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK

(Cupriavidus
necator) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 LEU A 129
LEU A 168
GLY A 163
TYR A 167
ALA A 146
 None
 1.15A 2bm9A-5aa5A:
undetectable		 2bm9A-5aa5A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5z PTLCIB4 H88A MUTANT

(Phaeodactylum
tricornutum) 		no annotation 5 GLY A  73
TYR A  99
CYH A 126
ALA A  72
ALA A 129
 None
None
ZN  A 500 (-2.3A)
None
None
 1.16A 2bm9A-5b5zA:
3.8		 2bm9A-5b5zA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		6 LEU A 423
LEU A 427
GLY A 398
TYR A 400
ALA A 395
ALA A 392
 None
 1.33A 2bm9A-5c3mA:
5.5		 2bm9A-5c3mA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfn STIMULATOR OF
INTERFERON GENES

(Nematostella
vectensis) 		PF15009
(TMEM173) 		5 LEU A 339
LEU A 211
GLU A 300
TYR A 349
ALA A 302
 None
 1.17A 2bm9A-5cfnA:
undetectable		 2bm9A-5cfnA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA1

(Lactobacillus
delbrueckii) 		PF00005
(ABC_tran) 		5 LEU A 183
LEU A 167
ARG A 187
ASP A 266
ALA A 207
 None
 1.05A 2bm9A-5d3mA:
undetectable		 2bm9A-5d3mA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Homo sapiens) 		PF00903
(Glyoxalase)
PF13669
(Glyoxalase_4) 		5 LEU A  50
SER A  54
ASP A  91
ALA A  29
ALA A  32
 LEU  A  50 ( 0.6A)
SER  A  54 ( 0.0A)
ASP  A  91 ( 0.6A)
ALA  A  29 ( 0.0A)
ALA  A  32 ( 0.0A)
 1.09A 2bm9A-5ec3A:
undetectable		 2bm9A-5ec3A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwo PROBABLE PROTEIN
PHOSPHATASE 2C 50

(Oryza sativa) 		PF00481
(PP2C) 		5 LEU A 268
LEU A 279
GLY A 275
CYH A 129
ALA A 203
 None
 1.15A 2bm9A-5gwoA:
undetectable		 2bm9A-5gwoA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy0 GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 LEU A 319
LEU A 328
TYR A 364
ALA A 335
ALA A 338
 None
 1.08A 2bm9A-5gy0A:
undetectable		 2bm9A-5gy0A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h35 MEMBRANE PROTEIN
TRIC

(Sulfolobus
solfataricus) 		PF03458
(UPF0126) 		5 LEU C 117
GLY C 108
SER C 114
ALA C 126
ALA C 157
 None
 1.15A 2bm9A-5h35C:
undetectable		 2bm9A-5h35C:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hnz PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL,PLUS-E
ND DIRECTED
KINESIN-1/KINESIN-14
,PROTEIN CLARET
SEGREGATIONAL,PROTEI
N CLARET
SEGREGATIONAL

(Drosophila
melanogaster;
Rattus
norvegicus) 		PF00225
(Kinesin) 		5 LEU K 248
LEU K 274
GLY K 335
ASP K  65
ALA K 338
 None
 1.14A 2bm9A-5hnzK:
undetectable		 2bm9A-5hnzK:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 LEU A 210
GLY A  89
SER A  40
ALA A 162
ALA A 165
 BAM  A 407 (-4.3A)
BAM  A 407 (-3.4A)
None
BAM  A 407 (-3.2A)
None
 1.08A 2bm9A-5jd4A:
2.1		 2bm9A-5jd4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		5 LEU A 569
LEU A 627
GLU A 632
GLY A 633
ALA A 606
 None
 1.07A 2bm9A-5jjhA:
undetectable		 2bm9A-5jjhA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 LEU A 294
LEU A 286
GLU A 676
SER A 268
ASP A 666
 None
 1.06A 2bm9A-5k8dA:
undetectable		 2bm9A-5k8dA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9z PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		5 LEU A 171
GLY A 127
ASP A  80
ALA A 131
ALA A 134
 None
None
GOL  A 301 (-3.2A)
None
GOL  A 301 (-3.9A)
 1.07A 2bm9A-5k9zA:
6.9		 2bm9A-5k9zA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		5 LEU A 528
LEU A 475
GLY A 555
ALA A 484
ALA A 488
 None
 0.98A 2bm9A-5kqiA:
undetectable		 2bm9A-5kqiA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1t MUCR
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		5 LEU A 539
GLU A 502
GLY A 501
SER A 542
ALA A 491
 None
 0.89A 2bm9A-5m1tA:
undetectable		 2bm9A-5m1tA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd4 TUBULIN ALPHA CHAIN

(Bos taurus) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 LEU A 428
LEU A 195
GLU A 168
SER A 198
ASP A 205
 None
 1.05A 2bm9A-5nd4A:
3.7		 2bm9A-5nd4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 GLY A  12
ARG A  37
ARG A  41
ASP A  59
ALA A  83
 NAP  A 301 (-3.3A)
NAP  A 301 (-3.5A)
NAP  A 301 (-3.0A)
NAP  A 301 (-3.8A)
NAP  A 301 ( 3.7A)
 0.90A 2bm9A-5t2uA:
6.3		 2bm9A-5t2uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttb SIDEROPHORE
YERSINIABACTIN

(Yersinia pestis) 		PF00550
(PP-binding) 		5 LEU A  55
LEU A  71
TYR A  75
ALA A  82
ALA A  81
 None
 1.09A 2bm9A-5ttbA:
undetectable		 2bm9A-5ttbA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S5-B,
PUTATIVE

(Trichomonas
vaginalis) 		PF00177
(Ribosomal_S7) 		5 GLY F 146
ARG F 180
ASP F 164
CYH F 161
ALA F 150
 None
 1.03A 2bm9A-5xyiF:
undetectable		 2bm9A-5xyiF:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yyl -

(-) 		no annotation 5 LEU A 317
GLY A 255
TYR A 266
ASP A  68
ALA A 308
 None
 1.08A 2bm9A-5yylA:
undetectable		 2bm9A-5yylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-) 		no annotation 5 LEU A 104
LEU A 108
GLY A 288
ASP A 308
ALA A 292
 None
 1.12A 2bm9A-6d95A:
3.0		 2bm9A-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC2
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation
no annotation 		5 LEU F 132
LEU G  59
GLU A 526
GLY F  95
ALA F  98
 None
 1.17A 2bm9A-6f42F:
undetectable		 2bm9A-6f42F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 5 LEU A  93
SER A 130
CYH A 306
ALA A 122
ALA A 119
 None
 1.12A 2bm9A-6fikA:
undetectable		 2bm9A-6fikA:
undetectable