SIMILAR PATTERNS OF AMINO ACIDS FOR 2BJF_A_DXCA330_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ati GLYCYL-TRNA
SYNTHETASE


(Thermus
thermophilus)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
5 ARG A 260
PHE A 230
ALA A 362
ILE A 229
LEU A  45
None
1.12A 2bjfA-1atiA:
0.0
2bjfA-1atiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE


(Pseudomonas
fluorescens)
PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5)
5 MET A   8
ASN A  92
ILE A 102
ILE A 104
LEU A  95
None
1.33A 2bjfA-1cjxA:
0.0
2bjfA-1cjxA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cul TYPE II ADENYLYL
CYCLASE


(Rattus
norvegicus)
PF00211
(Guanylate_cyc)
5 MET B 972
ALA B 946
ILE B 919
ILE B 918
LEU B 926
None
1.32A 2bjfA-1culB:
0.0
2bjfA-1culB:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE


(Triticum
aestivum)
PF00709
(Adenylsucc_synt)
5 CYH A 154
PHE A 217
ALA A 121
ILE A 115
ILE A 101
None
1.04A 2bjfA-1dj3A:
undetectable
2bjfA-1dj3A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens)
PF00704
(Glyco_hydro_18)
5 PHE A 154
ASN A 166
ILE A 141
ILE A 183
LEU A 165
None
1.21A 2bjfA-1e6zA:
0.0
2bjfA-1e6zA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE


(Escherichia
coli)
PF01182
(Glucosamine_iso)
5 CYH A 239
MET A 237
ALA A 215
THR A 251
LEU A 247
None
1.32A 2bjfA-1fs5A:
undetectable
2bjfA-1fs5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE


(Saccharomyces
cerevisiae)
PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5)
5 ASN A 258
ILE A 223
ILE A 185
THR A 279
LEU A 305
None
1.33A 2bjfA-1la2A:
0.0
2bjfA-1la2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr3 DNA-BINDING PROTEIN
TFX


(Methanothermobacter
thermautotrophicus)
PF14601
(TFX_C)
5 ALA A  24
ILE A  79
ILE A  11
THR A  84
LEU A  88
None
1.14A 2bjfA-1nr3A:
undetectable
2bjfA-1nr3A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ql0 NUCLEASE

(Serratia
marcescens)
PF01223
(Endonuclease_NS)
5 MET A 241
PHE A 188
ALA A 186
ILE A 218
THR A 144
None
1.21A 2bjfA-1ql0A:
1.4
2bjfA-1ql0A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaz ARCHAERHODOPSIN-1

(Halorubrum
chaoviator)
PF01036
(Bac_rhodopsin)
5 ALA A 132
ILE A 196
ILE A 197
THR A 199
LEU A  82
None
1.31A 2bjfA-1uazA:
undetectable
2bjfA-1uazA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1


(Saccharomyces
cerevisiae)
PF02463
(SMC_N)
5 TYR A  98
PHE A  23
ASN A 139
ILE A1186
ILE A  46
None
1.26A 2bjfA-1w1wA:
undetectable
2bjfA-1w1wA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE


(Plasmodium
falciparum)
PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C)
5 PHE A 203
ALA A 179
ASN A  78
ILE A 108
LEU A  87
None
1.12A 2bjfA-1yj8A:
undetectable
2bjfA-1yj8A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbs HYPOTHETICAL PROTEIN
PG1100


(Porphyromonas
gingivalis)
PF01869
(BcrAD_BadFG)
5 CYH A  70
PHE A  26
ILE A  53
ILE A  16
LEU A  82
None
1.28A 2bjfA-1zbsA:
undetectable
2bjfA-1zbsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1


(Medicago
truncatula)
PF00201
(UDPGT)
5 PHE A  45
ALA A  30
ILE A  13
ILE A 110
LEU A  40
None
1.33A 2bjfA-2acvA:
undetectable
2bjfA-2acvA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE


(Desulfovibrio
africanus)
PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II)
5 PHE A 470
ALA A 566
ASN A 560
ILE A 441
ILE A 438
None
1.18A 2bjfA-2c3oA:
undetectable
2bjfA-2c3oA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct8 METHIONYL-TRNA
SYNTHETASE


(Aquifex
aeolicus)
PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g)
5 ALA A 462
ASN A 457
ILE A 405
ILE A 402
THR A 455
None
1.24A 2bjfA-2ct8A:
undetectable
2bjfA-2ct8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fct SYRINGOMYCIN
BIOSYNTHESIS ENZYME
2


(Pseudomonas
syringae)
PF05721
(PhyH)
5 PHE A  24
ALA A 147
ILE A 228
ILE A  21
LEU A 158
None
1.19A 2bjfA-2fctA:
undetectable
2bjfA-2fctA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gup ROK FAMILY PROTEIN

(Streptococcus
pneumoniae)
PF00480
(ROK)
5 CYH A 103
ALA A  56
ASN A 274
ILE A  30
LEU A 275
None
None
SUC  A 290 (-2.8A)
None
None
1.21A 2bjfA-2gupA:
undetectable
2bjfA-2gupA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igt SAM DEPENDENT
METHYLTRANSFERASE


(Agrobacterium
fabrum)
PF10672
(Methyltrans_SAM)
5 CYH A 237
MET A 233
PHE A 140
ALA A 191
ILE A 167
None
None
SAM  A1001 (-4.4A)
SAM  A1001 (-3.6A)
ACY  A1009 (-4.5A)
1.31A 2bjfA-2igtA:
undetectable
2bjfA-2igtA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ii1 ACETAMIDASE

(Bacillus
halodurans)
PF03069
(FmdA_AmdA)
5 MET A  13
ASN A 154
ILE A  78
ILE A  81
LEU A 155
None
CA  A 400 (-2.8A)
None
None
None
1.11A 2bjfA-2ii1A:
undetectable
2bjfA-2ii1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv0 ISOCITRATE
DEHYDROGENASE


(Archaeoglobus
fulgidus)
PF00180
(Iso_dh)
5 MET A 205
TYR A 360
ALA A 122
ILE A 114
ILE A  88
None
1.06A 2bjfA-2iv0A:
undetectable
2bjfA-2iv0A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l10 TALIN-1

(Mus musculus)
PF08913
(VBS)
5 PHE A1281
ALA A1215
ILE A1308
ILE A1346
LEU A1316
None
1.08A 2bjfA-2l10A:
undetectable
2bjfA-2l10A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oc6 YDHG PROTEIN

(Bacillus
subtilis)
PF08818
(DUF1801)
5 TYR A   7
PHE A  45
ALA A  63
ILE A  27
THR A  20
GOL  A 128 (-3.6A)
None
None
None
None
1.06A 2bjfA-2oc6A:
undetectable
2bjfA-2oc6A:
17.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oqc PENICILLIN V ACYLASE

(Bacillus
subtilis)
PF02275
(CBAH)
5 CYH A   1
ARG A  17
MET A  19
ALA A  68
LEU A 142
None
0.34A 2bjfA-2oqcA:
43.3
2bjfA-2oqcA:
39.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q07 UNCHARACTERIZED
PROTEIN AF0587


(Archaeoglobus
fulgidus)
PF01472
(PUA)
5 PHE A 499
ALA A 452
ASN A 458
ILE A 520
THR A 461
None
1.15A 2bjfA-2q07A:
undetectable
2bjfA-2q07A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc5 STREPTOGRAMIN B
LACTONASE


(Staphylococcus
cohnii)
no annotation 5 PHE A 145
ASN A  75
ILE A  63
ILE A 112
THR A  73
PHE  A 145 ( 1.3A)
ASN  A  75 ( 0.6A)
ILE  A  63 ( 0.4A)
ILE  A 112 ( 0.7A)
THR  A  73 ( 0.8A)
1.30A 2bjfA-2qc5A:
undetectable
2bjfA-2qc5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis)
PF00480
(ROK)
5 ALA A 110
ASN A 113
ILE A  47
ILE A  43
THR A  72
None
1.17A 2bjfA-2qm1A:
undetectable
2bjfA-2qm1A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis)
PF00480
(ROK)
5 ALA A 312
ASN A 113
ILE A  15
ILE A  43
THR A  72
None
1.31A 2bjfA-2qm1A:
undetectable
2bjfA-2qm1A:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2quy PENICILLIN ACYLASE

(Lysinibacillus
sphaericus)
PF02275
(CBAH)
5 CYH A   1
ARG A  17
MET A  19
ILE A  62
ILE A 134
None
0.92A 2bjfA-2quyA:
42.9
2bjfA-2quyA:
36.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rg2 CHOLOYLGLYCINE
HYDROLASE


(Clostridium
perfringens)
PF02275
(CBAH)
7 MET A  20
PHE A  26
ALA A  68
ASN A  82
ILE A 137
THR A 140
LEU A 142
EDO  A 333 (-3.8A)
EDO  A 334 (-4.2A)
EDO  A 333 ( 3.7A)
GOL  A 336 (-3.7A)
None
None
EDO  A 333 ( 4.5A)
1.03A 2bjfA-2rg2A:
53.1
2bjfA-2rg2A:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rg2 CHOLOYLGLYCINE
HYDROLASE


(Clostridium
perfringens)
PF02275
(CBAH)
7 MET A  20
TYR A  24
ASN A  82
ILE A 133
ILE A 137
THR A 140
LEU A 142
EDO  A 333 (-3.8A)
None
GOL  A 336 (-3.7A)
None
None
None
EDO  A 333 ( 4.5A)
1.13A 2bjfA-2rg2A:
53.1
2bjfA-2rg2A:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rg2 CHOLOYLGLYCINE
HYDROLASE


(Clostridium
perfringens)
PF02275
(CBAH)
8 MET A  20
TYR A  24
PHE A  26
ALA A  68
ASN A  82
ILE A 133
THR A 140
LEU A 142
EDO  A 333 (-3.8A)
None
EDO  A 334 (-4.2A)
EDO  A 333 ( 3.7A)
GOL  A 336 (-3.7A)
None
None
EDO  A 333 ( 4.5A)
0.67A 2bjfA-2rg2A:
53.1
2bjfA-2rg2A:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rg2 CHOLOYLGLYCINE
HYDROLASE


(Clostridium
perfringens)
PF02275
(CBAH)
7 TYR A  24
PHE A  61
ASN A  82
ILE A 133
ILE A 137
THR A 140
LEU A 142
None
None
GOL  A 336 (-3.7A)
None
None
None
EDO  A 333 ( 4.5A)
1.32A 2bjfA-2rg2A:
53.1
2bjfA-2rg2A:
99.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpq ACETYL-COA
CARBOXYLASE


(Staphylococcus
aureus)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 PHE A 410
ALA A 402
ILE A 419
ILE A 339
LEU A 426
None
1.25A 2bjfA-2vpqA:
undetectable
2bjfA-2vpqA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE


(Methanocaldococcus
jannaschii)
PF00814
(Peptidase_M22)
PF01163
(RIO1)
5 ARG A 332
ALA A 240
ILE A 197
THR A 235
LEU A 124
None
1.32A 2bjfA-2vwbA:
undetectable
2bjfA-2vwbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2


(Neurospora
crassa)
PF02171
(Piwi)
5 MET A 869
PHE A 743
ILE A 779
THR A 658
LEU A 652
None
1.29A 2bjfA-2yhaA:
undetectable
2bjfA-2yhaA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqq METHYLGLUTACONYL-COA
HYDRATASE


(Homo sapiens)
PF00378
(ECH_1)
5 ARG A 146
PHE A 137
ALA A 141
ILE A  94
ILE A 129
None
1.27A 2bjfA-2zqqA:
undetectable
2bjfA-2zqqA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE


(Homo sapiens)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 PHE A 219
PHE A 174
ALA A 216
ILE A 144
LEU A 165
None
MYA  A   1 (-4.8A)
None
MYA  A   1 (-4.9A)
None
1.16A 2bjfA-3b96A:
undetectable
2bjfA-3b96A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b96 VERY LONG-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE


(Homo sapiens)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 PHE A 219
PHE A 174
ILE A 144
ILE A 296
LEU A 165
None
MYA  A   1 (-4.8A)
MYA  A   1 (-4.9A)
None
None
1.10A 2bjfA-3b96A:
undetectable
2bjfA-3b96A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE


(Homo sapiens)
PF00233
(PDEase_I)
5 MET A 578
PHE A 619
PHE A 564
ILE A 774
ILE A 778
None
1.32A 2bjfA-3bjcA:
undetectable
2bjfA-3bjcA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1


(Saccharomyces
cerevisiae)
PF00180
(Iso_dh)
5 ARG A 274
PHE A 230
ALA A 108
ILE A 214
THR A 235
FLC  A1001 (-3.4A)
None
None
None
None
1.13A 2bjfA-3blwA:
undetectable
2bjfA-3blwA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuc PROTEIN OF UNKNOWN
FUNCTION WITH A FIC
DOMAIN


(Bacteroides
thetaiotaomicron)
PF02661
(Fic)
5 ALA A 182
ASN A 207
ILE A   6
ILE A 266
LEU A 210
None
1.29A 2bjfA-3cucA:
undetectable
2bjfA-3cucA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ele AMINO TRANSFERASE

([Eubacterium]
rectale)
PF00155
(Aminotran_1_2)
5 PHE A 133
ILE A 214
ILE A 177
THR A 128
LEU A 147
PLP  A 500 (-4.0A)
None
None
None
None
1.19A 2bjfA-3eleA:
undetectable
2bjfA-3eleA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euw MYO-INOSITOL
DEHYDROGENASE


(Corynebacterium
glutamicum)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 ALA A  18
ASN A  24
ILE A  67
ILE A  88
LEU A 288
None
1.26A 2bjfA-3euwA:
undetectable
2bjfA-3euwA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae)
PF11715
(Nup160)
5 TYR A 313
PHE A 315
PHE A 373
THR A 289
LEU A 291
None
1.29A 2bjfA-3h7nA:
undetectable
2bjfA-3h7nA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE


(Lactobacillus
acidophilus)
PF04909
(Amidohydro_2)
5 ALA A 248
ILE A 276
ILE A 275
THR A 242
LEU A 283
None
1.32A 2bjfA-3ij6A:
undetectable
2bjfA-3ij6A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw0 CYSTEINE PEPTIDASE

(Bacillus cereus)
PF05708
(Peptidase_C92)
5 PHE A  27
ALA A 183
ASN A   7
ILE A  96
ILE A 194
None
1.25A 2bjfA-3kw0A:
undetectable
2bjfA-3kw0A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus)
PF00209
(SNF)
5 TYR A  47
PHE A  51
ALA A 283
ASN A  27
THR A 254
None
None
None
NA  A 752 ( 2.8A)
NA  A 752 ( 3.3A)
1.26A 2bjfA-3mpnA:
undetectable
2bjfA-3mpnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2n ANTHRAX TOXIN
RECEPTOR 1


(Homo sapiens)
no annotation 5 PHE F  82
ALA F  70
ILE F 146
ILE F 145
LEU F  78
None
1.19A 2bjfA-3n2nF:
undetectable
2bjfA-3n2nF:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956


(Vibrio
parahaemolyticus)
no annotation 5 ARG A 489
PHE A 105
ALA A 504
ILE A 125
ILE A 220
None
1.26A 2bjfA-3nlcA:
undetectable
2bjfA-3nlcA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opz HEAVY CHAIN OF THE
FAB FRAGMENT OF
IMMUNOGLOBULIN G


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 TYR H 181
ALA H 207
ILE H  93
THR H 116
LEU H  11
None
1.25A 2bjfA-3opzH:
undetectable
2bjfA-3opzH:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owa ACYL-COA
DEHYDROGENASE


(Bacillus
anthracis)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 PHE A 193
ALA A 190
ILE A 118
ILE A 261
LEU A 139
None
1.31A 2bjfA-3owaA:
undetectable
2bjfA-3owaA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE


(Francisella
tularensis)
PF00586
(AIRS)
PF02769
(AIRS_C)
5 MET A 320
PHE A 182
ALA A 312
ILE A 261
ILE A 252
None
1.25A 2bjfA-3qtyA:
undetectable
2bjfA-3qtyA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqz PUTATIVE
HYDROXYMETHYLGLUTARY
L-COA SYNTHASE


(Streptococcus
mutans)
PF00195
(Chal_sti_synt_N)
PF08540
(HMG_CoA_synt_C)
5 PHE A  10
ALA A  56
ILE A 158
ILE A 277
LEU A  76
GOL  A 392 (-4.9A)
None
None
None
None
1.19A 2bjfA-3sqzA:
undetectable
2bjfA-3sqzA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy6 FIMBRIAL PROTEIN
BF1861


(Bacteroides
fragilis)
PF13149
(Mfa_like_1)
5 PHE A 184
ALA A 289
ILE A 247
ILE A 182
THR A 164
None
1.30A 2bjfA-3sy6A:
undetectable
2bjfA-3sy6A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usw FLAGELLAR MOTOR
SWITCH PROTEIN


(Helicobacter
pylori)
PF01706
(FliG_C)
PF14841
(FliG_M)
5 ARG A 293
PHE A 286
ALA A 294
ILE A 259
ILE A 262
None
1.29A 2bjfA-3uswA:
undetectable
2bjfA-3uswA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp5 CDBFV

(Neocallimastix
patriciarum)
PF00457
(Glyco_hydro_11)
5 MET A  78
PHE A  66
ALA A 197
ILE A 153
THR A 103
None
1.34A 2bjfA-3wp5A:
undetectable
2bjfA-3wp5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE


(Thermococcus
litoralis)
PF04587
(ADP_PFK_GK)
5 ARG A 348
PHE A  20
ALA A 457
ILE A 394
ILE A 391
None
1.29A 2bjfA-4b8sA:
undetectable
2bjfA-4b8sA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4


(Dictyostelium
discoideum)
PF07714
(Pkinase_Tyr)
5 PHE A1219
ALA A1199
ASN A1194
ILE A1140
ILE A1136
None
1.17A 2bjfA-4f0gA:
undetectable
2bjfA-4f0gA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo7 METHIONINE
AMINOPEPTIDASE


(Pseudomonas
aeruginosa)
PF00557
(Peptidase_M24)
5 PHE A 112
ASN A  83
ILE A  32
ILE A  28
THR A  38
None
1.30A 2bjfA-4fo7A:
undetectable
2bjfA-4fo7A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikn AP-3 COMPLEX SUBUNIT
MU-1


(Rattus
norvegicus)
PF00928
(Adap_comp_sub)
5 MET A 314
PHE A 282
ASN A 372
THR A 418
LEU A 373
MET  A 314 ( 0.0A)
PHE  A 282 ( 1.3A)
ASN  A 372 ( 0.6A)
THR  A 418 ( 0.8A)
LEU  A 373 ( 0.5A)
1.19A 2bjfA-4iknA:
undetectable
2bjfA-4iknA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium)
PF05199
(GMC_oxred_C)
5 CYH A 560
PHE A  28
ALA A 608
ILE A 203
ILE A 204
None
1.26A 2bjfA-4mifA:
undetectable
2bjfA-4mifA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE


(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
5 TYR A 177
PHE A 303
ALA A 299
ILE A 243
ILE A 245
None
1.15A 2bjfA-4pj6A:
undetectable
2bjfA-4pj6A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CWC27 HOMOLOG


(Homo sapiens)
PF00160
(Pro_isomerase)
5 MET A 101
TYR A  49
ALA A  36
ILE A 174
LEU A  28
None
1.20A 2bjfA-4r3eA:
undetectable
2bjfA-4r3eA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sli INTRAMOLECULAR
TRANS-SIALIDASE


(Macrobdella
decora)
PF02973
(Sialidase)
PF13088
(BNR_2)
5 PHE A 248
ALA A 245
ILE A  94
ILE A 252
THR A 234
None
1.28A 2bjfA-4sliA:
undetectable
2bjfA-4sliA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wa8 FLAP ENDONUCLEASE 1

(Methanopyrus
kandleri)
PF00752
(XPG_N)
PF00867
(XPG_I)
5 ALA A  29
ILE A 185
ILE A  73
THR A  65
LEU A  61
None
1.25A 2bjfA-4wa8A:
undetectable
2bjfA-4wa8A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqe HOMOSPERMIDINE
SYNTHASE


(Blastochloris
viridis)
PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C)
5 PHE A  36
ALA A  81
ILE A  10
ILE A  30
LEU A  79
None
1.19A 2bjfA-4xqeA:
undetectable
2bjfA-4xqeA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8


(Homo sapiens)
PF00069
(Pkinase)
5 PHE A 271
ALA A 196
ASN A 111
ILE A 181
ILE A 190
None
1.28A 2bjfA-4y85A:
undetectable
2bjfA-4y85A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8


(Homo sapiens)
PF00069
(Pkinase)
5 PHE A 271
ALA A 196
ASN A 111
ILE A 190
LEU A 110
None
1.25A 2bjfA-4y85A:
undetectable
2bjfA-4y85A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yt9 PEPTIDYLARGININE
DEIMINASE


(Porphyromonas
gingivalis)
PF04371
(PAD_porph)
5 TYR A 189
ASN A 247
ILE A 380
ILE A 437
LEU A 370
None
GOL  A 506 ( 4.9A)
None
None
None
1.22A 2bjfA-4yt9A:
undetectable
2bjfA-4yt9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z38 MLNA

(Bacillus
velezensis)
no annotation 6 MET A 752
PHE A 566
ALA A 342
ILE A 550
ILE A 510
LEU A 344
None
1.39A 2bjfA-4z38A:
undetectable
2bjfA-4z38A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
5 TYR A 147
PHE A 112
ALA A 153
ILE A 130
ILE A 133
None
1.30A 2bjfA-5a7mA:
undetectable
2bjfA-5a7mA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN


(Campylobacter
jejuni)
PF01497
(Peripla_BP_2)
5 PHE A 245
ALA A 199
ASN A 221
ILE A 209
ILE A 215
None
1.07A 2bjfA-5advA:
undetectable
2bjfA-5advA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Cryptococcus
neoformans)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 TYR A 281
ALA A 293
ILE A 124
ILE A 221
LEU A 345
None
1.34A 2bjfA-5cefA:
undetectable
2bjfA-5cefA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT


(Azospira oryzae)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 PHE A 410
ALA A 223
ILE A 198
ILE A 418
LEU A 215
None
EDO  A1007 ( 3.7A)
None
None
None
1.33A 2bjfA-5chcA:
undetectable
2bjfA-5chcA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE


(Ignisphaera
aggregans)
PF01450
(IlvC)
PF07991
(IlvN)
5 MET A 472
TYR A 372
PHE A 373
ILE A 198
LEU A 381
None
1.29A 2bjfA-5e4rA:
undetectable
2bjfA-5e4rA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE


(Salmonella
enterica)
PF02664
(LuxS)
5 MET A  14
ALA A  16
ASN A  44
ILE A 142
ILE A  53
None
None
None
None
PAV  A 202 ( 4.2A)
1.29A 2bjfA-5e68A:
undetectable
2bjfA-5e68A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis)
PF14592
(Chondroitinas_B)
5 PHE A 207
ASN A 315
ILE A 216
ILE A 217
LEU A 278
None
1.18A 2bjfA-5gkqA:
undetectable
2bjfA-5gkqA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00118
(Cpn60_TCP1)
5 PHE a 139
PHE a 436
ALA a 428
ILE a 448
LEU a 455
None
1.02A 2bjfA-5gw5a:
undetectable
2bjfA-5gw5a:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN


(Lachnoclostridium
phytofermentans)
PF17167
(Glyco_hydro_36)
5 PHE A1107
ALA A1100
ASN A1073
ILE A1090
ILE A1067
None
1.12A 2bjfA-5h42A:
undetectable
2bjfA-5h42A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5j FERREDOXIN--NADP
REDUCTASE


(Zea mays)
PF00175
(NAD_binding_1)
5 MET A 158
PHE A 181
PHE A 205
ILE A 255
ILE A 262
None
1.32A 2bjfA-5h5jA:
undetectable
2bjfA-5h5jA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA
ATP SYNTHASE GAMMA
CHAIN


(Caldalkalibacillus
thermarum;
Caldalkalibacillus
thermarum)
PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
PF00231
(ATP-synt)
5 ARG G   5
PHE A 343
ALA A 323
ILE A 168
ILE A 335
None
1.17A 2bjfA-5ik2G:
undetectable
2bjfA-5ik2G:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER


(Shigella
flexneri)
PF02395
(Peptidase_S6)
5 PHE A 216
ALA A 122
ILE A 127
THR A 244
LEU A 249
None
1.32A 2bjfA-5j44A:
undetectable
2bjfA-5j44A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE


(Bacillus cereus)
PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11)
5 PHE A  91
PHE A  62
ALA A  55
ILE A   4
ILE A 150
None
1.07A 2bjfA-5je8A:
undetectable
2bjfA-5je8A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgg ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1


(Homo sapiens)
PF12859
(ANAPC1)
5 CYH A 152
MET A 161
ALA A 171
ILE A 403
LEU A 173
None
1.28A 2bjfA-5lggA:
undetectable
2bjfA-5lggA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1


(Homo sapiens)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
6 PHE A3868
PHE A3864
ALA A3872
ILE A3811
ILE A3890
LEU A3818
None
1.44A 2bjfA-5nugA:
undetectable
2bjfA-5nugA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE


(Methanocaldococcus
jannaschii)
no annotation 5 MET A 105
PHE A  20
ILE A 211
THR A 128
LEU A 131
None
1.32A 2bjfA-5od2A:
undetectable
2bjfA-5od2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S10,
PUTATIVE


(Trypanosoma
cruzi)
no annotation 5 PHE n  18
PHE n  17
ASN n  96
ILE n  23
ILE n  62
None
1.24A 2bjfA-5optn:
undetectable
2bjfA-5optn:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tte E3 UBIQUITIN-PROTEIN
LIGASE ARIH1


(Homo sapiens)
PF01485
(IBR)
5 ARG B 247
TYR B 258
ILE B 130
ILE B 133
LEU B 201
None
1.26A 2bjfA-5tteB:
undetectable
2bjfA-5tteB:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9z PHOSPHOGLYCEROL
TRANSFERASE


(Streptococcus
pyogenes)
no annotation 5 MET A 561
PHE A 535
ASN A 595
ILE A 645
LEU A 596
None
1.16A 2bjfA-5u9zA:
undetectable
2bjfA-5u9zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5


(Saccharomyces
cerevisiae)
PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB)
5 MET 5 497
PHE 5 550
PHE 5 554
ALA 5 521
ILE 5 384
None
1.26A 2bjfA-5udb5:
undetectable
2bjfA-5udb5:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upr TRIOSEPHOSPHATE
ISOMERASE


(Toxoplasma
gondii)
PF00121
(TIM)
5 PHE A 121
ALA A 327
ILE A 331
ILE A 245
LEU A 316
None
1.02A 2bjfA-5uprA:
undetectable
2bjfA-5uprA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbg CYTOCHROME P450 2B6

(Homo sapiens)
no annotation 5 PHE A 449
PHE A 450
ILE A 353
ILE A 356
THR A 303
None
None
None
None
HEM  A 501 ( 4.6A)
1.24A 2bjfA-5wbgA:
undetectable
2bjfA-5wbgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)


(Lachnospiraceae
bacterium
NK4A179)
no annotation 5 TYR A1263
PHE A1259
PHE A1365
ALA A1112
ILE A1327
None
1.11A 2bjfA-5wlhA:
undetectable
2bjfA-5wlhA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xip PROLYL-TRNA
SYNTHETASE, PUTATIVE


(Eimeria tenella)
no annotation 5 MET A 636
PHE A 587
ILE A 543
ILE A 545
THR A 611
None
1.24A 2bjfA-5xipA:
undetectable
2bjfA-5xipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn PLATINUM SENSITIVITY
PROTEIN 3


(Saccharomyces
cerevisiae)
no annotation 5 TYR A 215
PHE A 161
ILE A 133
ILE A  73
THR A 177
None
1.29A 2bjfA-5xynA:
undetectable
2bjfA-5xynA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1


(Saccharomyces
cerevisiae)
no annotation 5 PHE A 171
ASN A 112
ILE A  58
ILE A 257
LEU A 115
None
1.24A 2bjfA-5y58A:
undetectable
2bjfA-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bka NITRONATE
MONOOXYGENASE


(Cyberlindnera
mrakii)
no annotation 5 PHE A 176
ALA A 238
ILE A 220
ILE A 224
LEU A 250
None
FMN  A 401 ( 4.0A)
None
None
None
1.08A 2bjfA-6bkaA:
undetectable
2bjfA-6bkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE


(Pseudomonas
nitroreducens)
no annotation 5 PHE A 461
ASN A 327
ILE A 426
ILE A 425
LEU A 324
None
1.33A 2bjfA-6em0A:
undetectable
2bjfA-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus)
no annotation 5 TYR A1317
PHE A1280
ALA A1588
ILE A1299
LEU A1265
None
1.04A 2bjfA-6fb3A:
undetectable
2bjfA-6fb3A:
undetectable