SIMILAR PATTERNS OF AMINO ACIDS FOR 2BFP_D_H4BD1290_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1djp GLUTAMINASE-ASPARAGI
NASE

(Pseudomonas sp.
7A) 		PF00710
(Asparaginase) 		4 SER A1184
ASP A1307
LEU A1316
LEU A1112
 None
 1.01A 2bfpD-1djpA:
1.9		 2bfpD-1djpA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 PHE A 620
LEU A 587
LEU A 670
LEU A 615
 None
 1.04A 2bfpD-1g0dA:
0.0		 2bfpD-1g0dA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4e CASPASE-8

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 PHE B2274
LEU B2425
LEU B2400
LEU B2474
 None
 0.97A 2bfpD-1i4eB:
4.5		 2bfpD-1i4eB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihm CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 SER A1244
PHE A1421
LEU A1481
LEU A1233
 None
 0.99A 2bfpD-1ihmA:
undetectable		 2bfpD-1ihmA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		6 ARG A  22
SER A 103
ASP A 169
LEU A 176
TYR A 182
LEU A 217
 NDP  A1277 ( 3.9A)
MTX  A1278 ( 2.7A)
NDP  A1277 (-3.9A)
MTX  A1278 (-4.5A)
MTX  A1278 ( 4.7A)
None
 0.50A 2bfpD-1mxfA:
39.5		 2bfpD-1mxfA:
48.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158

(Thermotoga
maritima) 		PF00117
(GATase) 		4 PHE A 125
LEU A 170
LEU A 217
LEU A 221
 None
 0.95A 2bfpD-1o1yA:
0.9		 2bfpD-1o1yA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 ARG A 691
SER A 896
LEU A 383
LEU A 662
 None
 0.94A 2bfpD-1p2zA:
0.0		 2bfpD-1p2zA:
14.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p33 PTERIDINE REDUCTASE
1

(Leishmania
tarentolae) 		PF13561
(adh_short_C2) 		8 ARG A  17
SER A 111
PHE A 113
ASP A 181
LEU A 188
TYR A 194
LEU A 226
LEU A 229
 NDP  A 300 ( 3.7A)
MTX  A 351 ( 2.8A)
MTX  A 351 (-3.5A)
NDP  A 300 ( 3.7A)
MTX  A 351 (-4.5A)
MTX  A 351 ( 4.4A)
MTX  A 351 ( 4.4A)
MTX  A 351 (-4.9A)
 0.46A 2bfpD-1p33A:
43.8		 2bfpD-1p33A:
80.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pu1 HYPOTHETICAL PROTEIN
MTH677

(Methanothermobacter
thermautotrophicus) 		PF11419
(DUF3194) 		4 LEU A   6
TYR A  46
LEU A  86
LEU A  82
 None
 0.96A 2bfpD-1pu1A:
0.0		 2bfpD-1pu1A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS

(Escherichia
coli) 		PF01614
(IclR) 		4 ASP A 122
LEU A 130
LEU A  64
LEU A  44
 None
 0.94A 2bfpD-1tf1A:
undetectable		 2bfpD-1tf1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		4 ARG A 546
PHE A 622
LEU A 593
LEU A 630
 None
 0.97A 2bfpD-1w27A:
undetectable		 2bfpD-1w27A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avt DNA POLYMERASE III
BETA SUBUNIT

(Streptococcus
pyogenes) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 SER A 282
LEU A 292
LEU A 271
LEU A 338
 None
 1.01A 2bfpD-2avtA:
undetectable		 2bfpD-2avtA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7i PUTATIVE LIPOATE
PROTEIN LIGASE

(Thermoplasma
acidophilum) 		PF03099
(BPL_LplA_LipB) 		4 SER A  17
LEU A  86
LEU A  36
LEU A   5
 None
 0.93A 2bfpD-2c7iA:
undetectable		 2bfpD-2c7iA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwf RING FINGER PROTEIN
41
UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Homo sapiens) 		PF00581
(Rhodanese)
PF08941
(USP8_interact) 		4 PHE B 310
ASP A 241
LEU B 259
LEU B 306
 None
 0.94A 2bfpD-2gwfB:
undetectable		 2bfpD-2gwfB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk3 DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Staphylococcus
aureus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 PHE A 180
ASP A 283
LEU A  15
LEU A 291
 None
 1.02A 2bfpD-2hk3A:
undetectable		 2bfpD-2hk3A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 PHE A  22
TYR A  21
LEU A 106
LEU A 105
 None
 1.00A 2bfpD-2i14A:
undetectable		 2bfpD-2i14A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilr FANCONI ANEMIA GROUP
E PROTEIN

(Homo sapiens) 		PF11510
(FA_FANCE) 		4 SER A 389
PHE A 390
LEU A 355
LEU A 333
 None
 0.90A 2bfpD-2ilrA:
undetectable		 2bfpD-2ilrA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 ARG A 656
SER A 861
LEU A 353
LEU A 627
 MPD  A1706 (-3.6A)
None
None
None
 0.98A 2bfpD-2obeA:
undetectable		 2bfpD-2obeA:
14.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhx PTERIDINE REDUCTASE
1

(Leishmania
major) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		8 ARG A  17
SER A 111
PHE A 113
ASP A 181
LEU A 188
TYR A 194
LEU A 226
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
None
 0.26A 2bfpD-2qhxA:
45.6		 2bfpD-2qhxA:
87.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus) 		PF14589
(NrfD_2) 		4 SER C 169
LEU C  37
LEU C 157
LEU C 179
 None
 0.80A 2bfpD-2vpwC:
undetectable		 2bfpD-2vpwC:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1

(Schizosaccharomyces
pombe) 		PF10471
(ANAPC_CDC26)
PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 SER A 399
PHE A 396
LEU B   3
LEU A 358
 None
 0.91A 2bfpD-2xpiA:
undetectable		 2bfpD-2xpiA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG

(Homo sapiens) 		PF05712
(MRG) 		4 PHE A 487
LEU A 210
TYR A 213
LEU A 463
 None
 1.01A 2bfpD-2y0nA:
undetectable		 2bfpD-2y0nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 PHE A 165
LEU A 195
LEU A 231
LEU A 233
 None
 1.02A 2bfpD-2z65A:
undetectable		 2bfpD-2z65A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1f CYTOCHROME B-245
HEAVY CHAIN

(Homo sapiens) 		PF08030
(NAD_binding_6) 		4 SER A 168
PHE A 136
LEU A 158
LEU A 152
 None
 0.98A 2bfpD-3a1fA:
3.1		 2bfpD-3a1fA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		4 PHE A 112
LEU A 123
LEU A  93
LEU A 108
 None
 1.02A 2bfpD-3a3iA:
undetectable		 2bfpD-3a3iA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7k HALORHODOPSIN

(Natronomonas
pharaonis) 		PF01036
(Bac_rhodopsin) 		4 ARG A 176
TYR A 248
LEU A 164
LEU A 168
 None
 0.96A 2bfpD-3a7kA:
undetectable		 2bfpD-3a7kA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alf CHITINASE, CLASS V

(Nicotiana
tabacum) 		PF00704
(Glyco_hydro_18) 		4 SER A  93
PHE A  94
LEU A 126
LEU A 130
 None
 0.99A 2bfpD-3alfA:
undetectable		 2bfpD-3alfA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9j XANTHINE OXIDASE

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 SER B 368
PHE B 365
LEU B 348
LEU B 334
 None
 1.01A 2bfpD-3b9jB:
undetectable		 2bfpD-3b9jB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Mus musculus) 		PF05889
(SepSecS) 		4 PHE A 450
LEU A 352
LEU A 458
LEU A 391
 None
 0.86A 2bfpD-3bc8A:
undetectable		 2bfpD-3bc8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7j TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF00392
(GntR)
PF07729
(FCD) 		4 PHE A  56
LEU A  14
LEU A  47
LEU A  67
 None
 0.83A 2bfpD-3c7jA:
undetectable		 2bfpD-3c7jA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 SER A 156
PHE A 158
LEU A 198
LEU A 232
 None
 0.90A 2bfpD-3d1jA:
undetectable		 2bfpD-3d1jA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkx REPLICATION PROTEIN
REPB

(Streptococcus
agalactiae) 		PF01719
(Rep_2) 		4 PHE A  11
LEU A  13
LEU A  78
LEU A  29
 None
 1.00A 2bfpD-3dkxA:
undetectable		 2bfpD-3dkxA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		4 SER A 136
LEU A   4
LEU A  35
LEU A  11
 None
 0.78A 2bfpD-3ek2A:
25.5		 2bfpD-3ek2A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1) 		no annotation 4 SER A 749
PHE A 747
LEU A 791
LEU A 782
 None
 0.80A 2bfpD-3f95A:
undetectable		 2bfpD-3f95A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE

(Pseudomonas
putida) 		PF00180
(Iso_dh) 		4 ASP X 250
LEU X  90
TYR X 141
LEU X 280
 NAI  X 401 ( 4.5A)
None
None
None
 0.97A 2bfpD-3fmxX:
undetectable		 2bfpD-3fmxX:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxe TRYPTOPHANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		4 PHE A 104
LEU A  65
TYR A  68
LEU A  46
 None
 0.78A 2bfpD-3jxeA:
undetectable		 2bfpD-3jxeA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE

(Streptococcus
mutans) 		PF01048
(PNP_UDP_1) 		4 PHE A 258
LEU A  28
LEU A  70
LEU A 266
 None
 1.01A 2bfpD-3la8A:
undetectable		 2bfpD-3la8A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 SER A 827
LEU A 750
LEU A 822
LEU A 777
 ADP  A2101 ( 4.4A)
None
None
None
 0.83A 2bfpD-3lj0A:
undetectable		 2bfpD-3lj0A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		4 SER A 164
LEU A 405
LEU A 469
LEU A 471
 None
 0.89A 2bfpD-3mcaA:
undetectable		 2bfpD-3mcaA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mv9 ALPHA CHAIN OF THE
TK3 TCR

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 ASP D 155
LEU D 178
LEU D 152
LEU D 140
 None
 1.04A 2bfpD-3mv9D:
undetectable		 2bfpD-3mv9D:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n93 MALTOSE BINDING
PROTEIN-CRFR2 ALPHA

(Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 ASP A  45
TYR A  95
LEU A  10
LEU A   6
 None
 1.00A 2bfpD-3n93A:
undetectable		 2bfpD-3n93A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 SER B 368
PHE B 365
LEU B 348
LEU B 334
 None
 1.00A 2bfpD-3ns1B:
undetectable		 2bfpD-3ns1B:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh9 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(NAD(P)(+))

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		4 SER A 176
LEU A  75
LEU A 469
LEU A 125
 None
 0.91A 2bfpD-3rh9A:
4.6		 2bfpD-3rh9A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Bacteroides
thetaiotaomicron) 		PF13306
(LRR_5) 		4 PHE A 109
LEU A  71
LEU A  35
LEU A  56
 None
 0.74A 2bfpD-3sb4A:
undetectable		 2bfpD-3sb4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkn NUCLEOPORIN NUP82

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 294
TYR A 295
LEU A 350
LEU A 327
 None
 1.00A 2bfpD-3tknA:
undetectable		 2bfpD-3tknA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ARG A3767
SER A3912
LEU A4133
LEU A4204
 None
 0.93A 2bfpD-3vkgA:
undetectable		 2bfpD-3vkgA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus;
Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 PHE A  85
LEU A  89
LEU A 290
LEU A 284
 None
 1.02A 2bfpD-3waiA:
undetectable		 2bfpD-3waiA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eah FORMIN-LIKE PROTEIN
3

(Mus musculus) 		PF02181
(FH2) 		4 PHE A 914
LEU A 790
LEU A 763
LEU A 830
 None
 1.02A 2bfpD-4eahA:
undetectable		 2bfpD-4eahA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1) 		4 PHE B 189
LEU B 169
LEU B  77
LEU B  79
 None
 1.00A 2bfpD-4gmjB:
undetectable		 2bfpD-4gmjB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huj UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored) 		4 SER A  48
PHE A  20
LEU A 163
LEU A 134
 None
 1.04A 2bfpD-4hujA:
undetectable		 2bfpD-4hujA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ARG A 392
PHE A 424
ASP A 471
TYR A 417
 ACT  A 804 ( 2.9A)
None
None
None
 0.99A 2bfpD-4i1pA:
undetectable		 2bfpD-4i1pA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbu VIRULENCE-ASSOCIATED
V ANTIGEN

(Yersinia pestis) 		PF04792
(LcrV) 		4 PHE A 118
LEU A  35
LEU A  79
LEU A 126
 None
 0.87A 2bfpD-4jbuA:
undetectable		 2bfpD-4jbuA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfv BETA-CATENIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF08216
(CTNNBL) 		4 PHE A 386
LEU A 441
LEU A 415
LEU A 426
 None
 0.99A 2bfpD-4mfvA:
undetectable		 2bfpD-4mfvA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nur PSDSA

(Pseudomonas sp.
S9) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 PHE A 589
LEU A 627
LEU A 655
LEU A 585
 None
 0.92A 2bfpD-4nurA:
undetectable		 2bfpD-4nurA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2

(Streptococcus
pyogenes) 		no annotation 4 PHE A 400
ASP A 231
TYR A 117
LEU A 300
 None
 0.87A 2bfpD-4nuzA:
undetectable		 2bfpD-4nuzA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 PHE A 606
LEU A 653
LEU A 718
LEU A 697
 None
 0.99A 2bfpD-4p6wA:
undetectable		 2bfpD-4p6wA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 PHE A1320
LEU A1284
LEU A1273
LEU A1301
 None
 0.93A 2bfpD-4pj3A:
undetectable		 2bfpD-4pj3A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN

(Legionella
pneumophila) 		PF13855
(LRR_8) 		4 PHE A  44
LEU A  67
LEU A  56
LEU A  23
 None
 0.87A 2bfpD-4q62A:
undetectable		 2bfpD-4q62A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi3 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF16010
(CDH-cyt) 		4 PHE A  35
LEU A 153
LEU A 187
LEU A  39
 None
 0.99A 2bfpD-4qi3A:
undetectable		 2bfpD-4qi3A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxa SMALL G PROTEIN
SIGNALING MODULATOR
1

(Mus musculus) 		no annotation 4 PHE B 353
LEU B 278
LEU B 340
LEU B 326
 None
 0.75A 2bfpD-4qxaB:
undetectable		 2bfpD-4qxaB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1

(Escherichia
coli;
Rattus
norvegicus) 		PF03359
(GKAP)
PF13416
(SBP_bac_8) 		4 PHE A  85
LEU A  89
LEU A 290
LEU A 284
 None
 1.01A 2bfpD-4r0yA:
undetectable		 2bfpD-4r0yA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1i AMINOBENZOYL-GLUTAMA
TE TRANSPORTER

(Neisseria
gonorrhoeae) 		PF03806
(ABG_transport) 		4 PHE A 370
LEU A  38
LEU A  79
LEU A  83
 None
 0.96A 2bfpD-4r1iA:
undetectable		 2bfpD-4r1iA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Homo sapiens) 		PF01704
(UDPGP) 		4 PHE A 446
LEU A 432
TYR A 442
LEU A 455
 None
 1.03A 2bfpD-4r7pA:
undetectable		 2bfpD-4r7pA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdj CAPSID

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 SER A 437
PHE A 439
LEU A 390
LEU A 401
 None
 0.98A 2bfpD-4rdjA:
undetectable		 2bfpD-4rdjA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 PHE A 502
LEU A 217
LEU A 263
LEU A 238
 None
None
SGV  A 601 (-4.5A)
None
 0.91A 2bfpD-4tnbA:
undetectable		 2bfpD-4tnbA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbd BSHC

(Bacillus
subtilis) 		PF10079
(BshC) 		4 ARG A 205
PHE A 213
LEU A  96
LEU A 197
 None
 0.92A 2bfpD-4wbdA:
undetectable		 2bfpD-4wbdA:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wcd PTERIDINE REDUCTASE

(Trypanosoma
brucei) 		PF13561
(adh_short_C2) 		6 ARG A  14
SER A  95
PHE A  97
ASP A 161
TYR A 174
LEU A 209
 NAP  A 301 (-3.7A)
NAP  A 301 ( 3.1A)
3KH  A 302 (-3.5A)
NAP  A 301 ( 3.8A)
3KH  A 302 ( 4.7A)
None
 0.44A 2bfpD-4wcdA:
40.5		 2bfpD-4wcdA:
48.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 SER C 162
PHE A 398
LEU A  67
LEU A  72
 None
MGN  A 402 (-4.2A)
None
None
 0.92A 2bfpD-5a8rC:
undetectable		 2bfpD-5a8rC:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5byk SULFOTRANSFERASE

(Schistosoma
mansoni) 		no annotation 4 LEU A 149
TYR A 154
LEU A 240
LEU A 236
 None
 0.98A 2bfpD-5bykA:
undetectable		 2bfpD-5bykA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		4 ARG A 104
PHE A 328
LEU A 342
LEU A 389
 None
 1.03A 2bfpD-5ddsA:
undetectable		 2bfpD-5ddsA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Vibrio cholerae) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		4 PHE A 234
LEU A 201
LEU A 251
LEU A 255
 None
 0.93A 2bfpD-5dt9A:
4.8		 2bfpD-5dt9A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7g IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		no annotation 4 SER A 308
PHE A 312
LEU A 287
LEU A 315
 EDO  A 515 (-4.4A)
None
None
None
 1.02A 2bfpD-5e7gA:
undetectable		 2bfpD-5e7gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7h IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		PF01833
(TIG) 		4 SER A 308
PHE A 312
LEU A 287
LEU A 315
 None
 1.02A 2bfpD-5e7hA:
undetectable		 2bfpD-5e7hA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2v GTP
PYROPHOSPHOKINASE
YJBM

(Bacillus
subtilis) 		no annotation 4 ASP V  98
LEU V  20
LEU V  93
LEU V 121
 None
 0.84A 2bfpD-5f2vV:
undetectable		 2bfpD-5f2vV:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmb TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Pseudomonas
aeruginosa) 		PF00588
(SpoU_methylase) 		4 SER A  74
LEU A 101
LEU A   2
LEU A  30
 None
 0.90A 2bfpD-5gmbA:
undetectable		 2bfpD-5gmbA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 SER A 214
LEU A 163
LEU A 176
LEU A 173
 None
 0.92A 2bfpD-5gr8A:
undetectable		 2bfpD-5gr8A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 LEU A  56
TYR A 120
LEU A  24
LEU A 239
 None
 0.82A 2bfpD-5hc4A:
4.4		 2bfpD-5hc4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 PHE A  85
LEU A  89
LEU A1290
LEU A1284
 None
 1.02A 2bfpD-5k94A:
undetectable		 2bfpD-5k94A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l25 BORON TRANSPORTER 1

(Arabidopsis
thaliana) 		PF00955
(HCO3_cotransp) 		4 SER A 125
TYR A 103
LEU A 339
LEU A 136
 None
 0.88A 2bfpD-5l25A:
undetectable		 2bfpD-5l25A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn HEXON PROTEIN,HEXON
CAPSID

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 ARG A 675
SER A 880
LEU A 371
LEU A 646
 None
 0.90A 2bfpD-5ldnA:
undetectable		 2bfpD-5ldnA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx0 FIBROMODULIN

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 329
LEU A 285
LEU A 300
LEU A 298
 None
 1.03A 2bfpD-5mx0A:
undetectable		 2bfpD-5mx0A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myf DUTPASE FROM DI S.
AUREUS PHAGE

(Staphylococcus
aureus) 		no annotation 4 PHE D  92
LEU D   5
LEU D  72
LEU D  76
 None
 0.88A 2bfpD-5myfD:
undetectable		 2bfpD-5myfD:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		4 PHE A 173
LEU A 492
LEU A 201
LEU A 181
 None
 0.98A 2bfpD-5n6mA:
undetectable		 2bfpD-5n6mA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 4 SER A 135
PHE A 218
LEU A 169
LEU A 232
 None
 0.83A 2bfpD-5nn8A:
undetectable		 2bfpD-5nn8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 SER T 818
LEU T 727
LEU T 765
LEU T 744
 None
 0.94A 2bfpD-5ojsT:
undetectable		 2bfpD-5ojsT:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5omm CAPSID PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		4 SER A 240
PHE A 442
LEU A 505
LEU A 229
 None
 0.99A 2bfpD-5ommA:
undetectable		 2bfpD-5ommA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy4 CHAPERONE YAJL

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		4 SER A  98
PHE A  95
LEU A   6
LEU A  87
 None
 0.94A 2bfpD-5sy4A:
undetectable		 2bfpD-5sy4A:
22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE

(Brucella suis) 		PF00106
(adh_short) 		5 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.48A 2bfpD-5tgdA:
30.2		 2bfpD-5tgdA:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		4 SER A 279
LEU A 190
LEU A 209
LEU A 204
 None
 0.97A 2bfpD-5u1sA:
undetectable		 2bfpD-5u1sA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR

(Escherichia
coli;
Homo sapiens) 		no annotation 4 PHE A  87
LEU A  91
LEU A 292
LEU A 286
 None
 1.03A 2bfpD-5v6yA:
undetectable		 2bfpD-5v6yA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA

(Acinetobacter
baumannii;
Escherichia
coli) 		no annotation 4 PHE A  85
LEU A  89
LEU A 290
LEU A 284
 None
 1.04A 2bfpD-5vawA:
undetectable		 2bfpD-5vawA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc2 SERINE
HYDROXYMETHYLTRANSFE
RASE

(Helicobacter
pylori) 		PF00464
(SHMT) 		4 PHE A 318
TYR A 323
LEU A 297
LEU A 304
 None
 0.75A 2bfpD-5vc2A:
undetectable		 2bfpD-5vc2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3h URACIL-DNA
GLYCOSYLASE

(Nitratifractor
salsuginis) 		no annotation 4 SER A 219
LEU A 167
LEU A  31
LEU A  35
 None
 0.95A 2bfpD-5x3hA:
undetectable		 2bfpD-5x3hA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1
SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 4 SER G 467
ASP C 494
LEU C 413
LEU C 260
 None
 0.89A 2bfpD-5x6oG:
undetectable		 2bfpD-5x6oG:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 4 SER D1012
LEU D 986
LEU D1044
LEU D1048
 None
 0.91A 2bfpD-5xbkD:
undetectable		 2bfpD-5xbkD:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfg RAN GUANINE
NUCLEOTIDE RELEASE
FACTOR

(Homo sapiens) 		no annotation 4 SER A  26
ASP A  33
LEU A   9
LEU A  51
 None
 0.96A 2bfpD-5yfgA:
undetectable		 2bfpD-5yfgA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9r HYDROXYETHYLPHOSPHON
ATE DIOXYGENASE

(Streptomyces
albus) 		no annotation 4 PHE A 330
LEU A 358
LEU A 367
LEU A 414
 None
 1.02A 2bfpD-6b9rA:
undetectable		 2bfpD-6b9rA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cud SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 3

(Homo sapiens) 		no annotation 4 PHE A  31
LEU A  47
LEU A  87
LEU A  66
 None
 0.94A 2bfpD-6cudA:
undetectable		 2bfpD-6cudA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ewx PEAK1-RELATED
KINASE-ACTIVATING
PSEUDOKINASE 1

(Rattus
norvegicus) 		no annotation 4 PHE A1179
LEU A1110
LEU A1120
LEU A1125
 None
 1.02A 2bfpD-6ewxA:
undetectable		 2bfpD-6ewxA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 4 SER A 586
LEU A 555
LEU A 549
LEU A 540
 None
 0.97A 2bfpD-6fnwA:
undetectable		 2bfpD-6fnwA:
15.56