SIMILAR PATTERNS OF AMINO ACIDS FOR 2BFP_C_H4BC1290_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a88 CHLOROPEROXIDASE L

(Streptomyces
lividans) 		PF00561
(Abhydrolase_1) 		4 SER A  46
PHE A  44
LEU A 265
LEU A 258
 None
 1.00A 2bfpC-1a88A:
5.2		 2bfpC-1a88A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		4 PHE A 407
LEU A 358
LEU A 353
LEU A 379
 None
 0.93A 2bfpC-1gl6A:
undetectable		 2bfpC-1gl6A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4e CASPASE-8

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 PHE B2274
LEU B2425
LEU B2400
LEU B2474
 None
 0.97A 2bfpC-1i4eB:
4.5		 2bfpC-1i4eB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		4 SER A  96
PHE A 128
LEU A 184
LEU A 146
 G  D 915 ( 4.2A)
None
None
None
 0.95A 2bfpC-1j2bA:
undetectable		 2bfpC-1j2bA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 SER B 316
PHE B 422
LEU B 309
LEU B 499
LEU B 512
 None
 1.41A 2bfpC-1m2vB:
2.7		 2bfpC-1m2vB:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 SER C 159
PHE A 396
LEU A  64
LEU A  69
 None
MGN  A 400 (-4.2A)
None
None
 0.91A 2bfpC-1mroC:
undetectable		 2bfpC-1mroC:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		6 ARG A  22
SER A 103
ASP A 169
LEU A 176
TYR A 182
LEU A 217
 NDP  A1277 ( 3.9A)
MTX  A1278 ( 2.7A)
NDP  A1277 (-3.9A)
MTX  A1278 (-4.5A)
MTX  A1278 ( 4.7A)
None
 0.46A 2bfpC-1mxfA:
39.6		 2bfpC-1mxfA:
48.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		6 ARG A  22
SER A 103
ASP A 169
TYR A 182
LEU A 214
LEU A 217
 NDP  A1277 ( 3.9A)
MTX  A1278 ( 2.7A)
NDP  A1277 (-3.9A)
MTX  A1278 ( 4.7A)
MTX  A1278 (-4.4A)
None
 0.75A 2bfpC-1mxfA:
39.6		 2bfpC-1mxfA:
48.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158

(Thermotoga
maritima) 		PF00117
(GATase) 		4 PHE A 125
LEU A 170
LEU A 217
LEU A 221
 None
 0.94A 2bfpC-1o1yA:
undetectable		 2bfpC-1o1yA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 PHE Q 299
TYR Q 300
LEU Q 379
LEU Q 381
 None
 0.96A 2bfpC-1oh2Q:
undetectable		 2bfpC-1oh2Q:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 ARG A 691
SER A 896
LEU A 383
LEU A 662
 None
 0.92A 2bfpC-1p2zA:
undetectable		 2bfpC-1p2zA:
14.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p33 PTERIDINE REDUCTASE
1

(Leishmania
tarentolae) 		PF13561
(adh_short_C2) 		8 ARG A  17
SER A 111
PHE A 113
ASP A 181
LEU A 188
TYR A 194
LEU A 226
LEU A 229
 NDP  A 300 ( 3.7A)
MTX  A 351 ( 2.8A)
MTX  A 351 (-3.5A)
NDP  A 300 ( 3.7A)
MTX  A 351 (-4.5A)
MTX  A 351 ( 4.4A)
MTX  A 351 ( 4.4A)
MTX  A 351 (-4.9A)
 0.44A 2bfpC-1p33A:
44.0		 2bfpC-1p33A:
80.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p33 PTERIDINE REDUCTASE
1

(Leishmania
tarentolae) 		PF13561
(adh_short_C2) 		4 SER A 111
PHE A 113
TYR A 194
LEU A 226
 MTX  A 351 ( 2.8A)
MTX  A 351 (-3.5A)
MTX  A 351 ( 4.4A)
MTX  A 351 ( 4.4A)
 0.99A 2bfpC-1p33A:
44.0		 2bfpC-1p33A:
80.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 SER A 316
PHE A 422
LEU A 309
LEU A 499
LEU A 512
 None
 1.39A 2bfpC-1pd1A:
2.5		 2bfpC-1pd1A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pu1 HYPOTHETICAL PROTEIN
MTH677

(Methanothermobacter
thermautotrophicus) 		PF11419
(DUF3194) 		4 LEU A   6
TYR A  46
LEU A  86
LEU A  82
 None
 0.97A 2bfpC-1pu1A:
undetectable		 2bfpC-1pu1A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)

(Burkholderia
glumae) 		PF00561
(Abhydrolase_1) 		4 SER D 117
PHE D 119
LEU D 161
LEU D 127
 None
 0.91A 2bfpC-1qgeD:
2.3		 2bfpC-1qgeD:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcd L FERRITIN

(Rana
catesbeiana) 		PF00210
(Ferritin) 		5 PHE A 128
LEU A  65
TYR A  68
LEU A 110
LEU A 134
 None
 1.44A 2bfpC-1rcdA:
undetectable		 2bfpC-1rcdA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5t DIHYDRODIPICOLINATE
SYNTHASE

(Escherichia
coli) 		PF00701
(DHDPS) 		4 SER A  34
LEU A 259
TYR A  30
LEU A 239
 None
 0.96A 2bfpC-1s5tA:
undetectable		 2bfpC-1s5tA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjj ACTININ

(Gallus gallus) 		PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen) 		4 SER A  74
LEU A  66
LEU A  98
LEU A 108
 None
 0.99A 2bfpC-1sjjA:
undetectable		 2bfpC-1sjjA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS

(Escherichia
coli) 		PF01614
(IclR) 		4 ASP A 122
LEU A 130
LEU A  64
LEU A  44
 None
 0.92A 2bfpC-1tf1A:
undetectable		 2bfpC-1tf1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		4 SER C 557
PHE C 559
LEU C 546
LEU C 568
 None
 0.87A 2bfpC-1u6gC:
undetectable		 2bfpC-1u6gC:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 PHE A 175
LEU A 203
TYR A 202
LEU A 219
LEU A 218
 None
 1.36A 2bfpC-1uedA:
undetectable		 2bfpC-1uedA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		4 ASP A  41
TYR A 175
LEU A  71
LEU A 186
 YSA  A3001 (-3.9A)
YSA  A3001 (-4.3A)
None
None
 0.97A 2bfpC-1vbmA:
5.4		 2bfpC-1vbmA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		4 LEU A 321
TYR A 320
LEU A 296
LEU A 359
 None
None
GER  A 952 ( 4.9A)
GER  A 952 ( 4.8A)
 0.94A 2bfpC-1vg0A:
4.0		 2bfpC-1vg0A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		4 ARG A 546
PHE A 622
LEU A 593
LEU A 630
 None
 0.95A 2bfpC-1w27A:
undetectable		 2bfpC-1w27A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8a SLIT PROTEIN

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 PHE A 688
LEU A 674
LEU A 669
LEU A 666
 None
 0.95A 2bfpC-1w8aA:
undetectable		 2bfpC-1w8aA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Pseudomonas
aeruginosa) 		PF05690
(ThiG) 		5 ARG A1016
PHE A1011
LEU A1191
LEU A1077
LEU A1105
 None
 1.49A 2bfpC-1wv2A:
undetectable		 2bfpC-1wv2A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuw GLUTAMATE RACEMASE 1

(Bacillus
subtilis) 		PF01177
(Asp_Glu_race) 		4 SER A 208
LEU A 148
LEU A 143
LEU A 173
 None
 0.93A 2bfpC-1zuwA:
3.2		 2bfpC-1zuwA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00342
(PGI) 		4 PHE A 247
LEU A 257
LEU A 366
LEU A   2
 None
 0.96A 2bfpC-1zzgA:
4.0		 2bfpC-1zzgA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6v EMP46P

(Saccharomyces
cerevisiae) 		PF03388
(Lectin_leg-like) 		5 SER A 196
PHE A 192
LEU A 132
LEU A 175
LEU A 165
 None
 1.39A 2bfpC-2a6vA:
undetectable		 2bfpC-2a6vA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bco SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio
parahaemolyticus) 		PF04952
(AstE_AspA) 		4 PHE A 116
ASP A 153
LEU A 112
LEU A 136
 None
 0.98A 2bfpC-2bcoA:
undetectable		 2bfpC-2bcoA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		4 SER A  22
LEU A  17
LEU A 312
LEU A 324
 None
 0.88A 2bfpC-2bwgA:
undetectable		 2bfpC-2bwgA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzu FIBER PROTEIN 2

(Human
mastadenovirus
F) 		PF00541
(Adeno_knob) 		4 PHE A 381
LEU A 256
LEU A 288
LEU A 286
 None
 0.98A 2bfpC-2bzuA:
undetectable		 2bfpC-2bzuA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE

(Vitis vinifera) 		PF00201
(UDPGT) 		4 SER A 439
PHE A 222
LEU A 425
LEU A 356
 None
 0.93A 2bfpC-2c1zA:
7.4		 2bfpC-2c1zA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7i PUTATIVE LIPOATE
PROTEIN LIGASE

(Thermoplasma
acidophilum) 		PF03099
(BPL_LplA_LipB) 		4 SER A  17
LEU A  86
LEU A  36
LEU A   5
 None
 0.92A 2bfpC-2c7iA:
undetectable		 2bfpC-2c7iA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cv6 SEED STORAGE PROTEIN

(Vigna radiata) 		PF00190
(Cupin_1) 		4 SER A 146
PHE A 144
LEU A  35
LEU A 116
 None
 0.95A 2bfpC-2cv6A:
undetectable		 2bfpC-2cv6A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII

(Thermococcus
kodakarensis) 		PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 LEU A 532
TYR A 534
LEU A 128
LEU A  11
 None
 0.94A 2bfpC-2cw7A:
undetectable		 2bfpC-2cw7A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1) 		4 PHE A 189
LEU A 169
LEU A  77
LEU A  79
 None
 0.99A 2bfpC-2d5rA:
undetectable		 2bfpC-2d5rA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9x OXYSTEROL BINDING
PROTEIN-RELATED
PROTEIN 11

(Homo sapiens) 		PF00169
(PH) 		5 SER A  65
PHE A  72
LEU A  14
LEU A  38
LEU A  57
 None
 1.49A 2bfpC-2d9xA:
undetectable		 2bfpC-2d9xA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Sulfurisphaera
tokodaii) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 PHE A 162
LEU A  19
LEU A  61
LEU A  72
 None
 0.97A 2bfpC-2e0iA:
2.3		 2bfpC-2e0iA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		4 PHE A 172
LEU A 492
LEU A 178
LEU A 160
 None
 0.94A 2bfpC-2f9qA:
undetectable		 2bfpC-2f9qA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9b CALBINDIN

(Rattus
norvegicus) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		4 SER A 156
LEU A 178
LEU A 241
LEU A 252
 None
 0.95A 2bfpC-2g9bA:
undetectable		 2bfpC-2g9bA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwf RING FINGER PROTEIN
41
UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Homo sapiens) 		PF00581
(Rhodanese)
PF08941
(USP8_interact) 		4 PHE B 310
ASP A 241
LEU B 259
LEU B 306
 None
 0.92A 2bfpC-2gwfB:
undetectable		 2bfpC-2gwfB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i00 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 PHE A 311
LEU A 336
LEU A 391
LEU A 365
 None
 0.92A 2bfpC-2i00A:
undetectable		 2bfpC-2i00A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 PHE A  22
TYR A  21
LEU A 106
LEU A 105
 None
 0.97A 2bfpC-2i14A:
undetectable		 2bfpC-2i14A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3d HYPOTHETICAL PROTEIN
ATU1826

(Agrobacterium
fabrum) 		PF02129
(Peptidase_S15) 		4 SER A  71
PHE A  63
LEU A  31
LEU A  82
 None
 0.94A 2bfpC-2i3dA:
3.9		 2bfpC-2i3dA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilr FANCONI ANEMIA GROUP
E PROTEIN

(Homo sapiens) 		PF11510
(FA_FANCE) 		4 SER A 389
PHE A 390
LEU A 355
LEU A 333
 None
 0.93A 2bfpC-2ilrA:
undetectable		 2bfpC-2ilrA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		4 ASP A 165
LEU A 139
LEU A 160
LEU A 170
 None
 0.96A 2bfpC-2imrA:
2.9		 2bfpC-2imrA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2la3 UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF06042
(NTP_transf_6) 		5 SER A  42
PHE A  46
LEU A  12
LEU A 146
LEU A 150
 None
 1.34A 2bfpC-2la3A:
undetectable		 2bfpC-2la3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		4 PHE A 487
LEU A 170
LEU A 449
LEU A 313
 None
 0.98A 2bfpC-2nnjA:
undetectable		 2bfpC-2nnjA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ASP A 720
LEU A 718
LEU A 479
LEU A 484
 None
 0.99A 2bfpC-2nztA:
undetectable		 2bfpC-2nztA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 ARG A 656
SER A 861
LEU A 353
LEU A 627
 MPD  A1706 (-3.6A)
None
None
None
 0.96A 2bfpC-2obeA:
undetectable		 2bfpC-2obeA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p65 HYPOTHETICAL PROTEIN
PF08_0063

(Plasmodium
falciparum) 		PF00004
(AAA) 		4 PHE A  99
ASP A 139
LEU A 144
LEU A 107
 None
 0.93A 2bfpC-2p65A:
undetectable		 2bfpC-2p65A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10

(Homo sapiens) 		PF00270
(DEAD) 		5 SER A 210
PHE A 211
LEU A 201
LEU A 243
LEU A 216
 None
 1.45A 2bfpC-2pl3A:
2.1		 2bfpC-2pl3A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 4 SER A 528
LEU A 554
LEU A 487
LEU A 491
 None
 0.96A 2bfpC-2po4A:
undetectable		 2bfpC-2po4A:
15.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhx PTERIDINE REDUCTASE
1

(Leishmania
major) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		8 ARG A  17
SER A 111
PHE A 113
ASP A 181
LEU A 188
TYR A 194
LEU A 226
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
None
 0.23A 2bfpC-2qhxA:
45.6		 2bfpC-2qhxA:
87.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uy3 ENDOCHITINASE

(Saccharomyces
cerevisiae) 		PF00704
(Glyco_hydro_18) 		4 PHE A  71
LEU A 105
LEU A  67
LEU A  83
 None
 0.84A 2bfpC-2uy3A:
3.5		 2bfpC-2uy3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus) 		PF14589
(NrfD_2) 		4 SER C 169
LEU C  37
LEU C 157
LEU C 179
 None
 0.79A 2bfpC-2vpwC:
undetectable		 2bfpC-2vpwC:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqw INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 SER A  49
PHE A  53
LEU A 105
LEU A 116
LEU A 119
 None
 1.45A 2bfpC-2wqwA:
undetectable		 2bfpC-2wqwA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY

(Staphylococcus
aureus) 		PF00561
(Abhydrolase_1) 		4 PHE A  19
TYR A  30
LEU A 211
LEU A 209
 None
 0.99A 2bfpC-2xmzA:
4.2		 2bfpC-2xmzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1

(Schizosaccharomyces
pombe) 		PF10471
(ANAPC_CDC26)
PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 SER A 399
PHE A 396
LEU B   3
LEU A 358
 None
 0.93A 2bfpC-2xpiA:
undetectable		 2bfpC-2xpiA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4f PEROXIDASE YCDB

(Escherichia
coli) 		PF04261
(Dyp_perox) 		4 PHE A  63
LEU A 144
LEU A 169
LEU A  55
 None
 0.93A 2bfpC-2y4fA:
undetectable		 2bfpC-2y4fA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5q INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 SER A  49
PHE A  53
LEU A 105
LEU A 116
LEU A 119
 None
 1.40A 2bfpC-2y5qA:
undetectable		 2bfpC-2y5qA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 PHE A 165
LEU A 195
LEU A 231
LEU A 233
 None
 1.00A 2bfpC-2z65A:
undetectable		 2bfpC-2z65A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 PHE A 162
LEU A 139
LEU A 154
LEU A 179
 None
 0.99A 2bfpC-2z7xA:
undetectable		 2bfpC-2z7xA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z80 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 PHE A 162
LEU A 139
LEU A 154
LEU A 179
 None
 1.00A 2bfpC-2z80A:
undetectable		 2bfpC-2z80A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PHE A 162
LEU A 139
LEU A 154
LEU A 179
 None
 1.00A 2bfpC-2z81A:
undetectable		 2bfpC-2z81A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
sporotrichioides) 		PF02458
(Transferase) 		4 PHE A 400
LEU A 150
LEU A  55
LEU A 180
 None
 1.00A 2bfpC-2zbaA:
undetectable		 2bfpC-2zbaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zl5 58 KD CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 PHE A 421
LEU A 437
LEU A 233
LEU A 459
 None
 1.00A 2bfpC-2zl5A:
undetectable		 2bfpC-2zl5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1f CYTOCHROME B-245
HEAVY CHAIN

(Homo sapiens) 		PF08030
(NAD_binding_6) 		4 SER A 168
PHE A 136
LEU A 158
LEU A 152
 None
 0.99A 2bfpC-3a1fA:
3.2		 2bfpC-3a1fA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		4 PHE A 112
LEU A 123
LEU A  93
LEU A 108
 None
 1.00A 2bfpC-3a3iA:
undetectable		 2bfpC-3a3iA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7k HALORHODOPSIN

(Natronomonas
pharaonis) 		PF01036
(Bac_rhodopsin) 		4 ARG A 176
TYR A 248
LEU A 164
LEU A 168
 None
 0.95A 2bfpC-3a7kA:
undetectable		 2bfpC-3a7kA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alf CHITINASE, CLASS V

(Nicotiana
tabacum) 		PF00704
(Glyco_hydro_18) 		4 SER A  93
PHE A  94
LEU A 126
LEU A 130
 None
 0.97A 2bfpC-3alfA:
undetectable		 2bfpC-3alfA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Mus musculus) 		PF05889
(SepSecS) 		4 PHE A 450
LEU A 352
LEU A 458
LEU A 391
 None
 0.84A 2bfpC-3bc8A:
undetectable		 2bfpC-3bc8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byd BETA-LACTAMASE OXY-1

(Klebsiella
oxytoca) 		PF13354
(Beta-lactamase2) 		4 SER A 109
ASP A 104
LEU A  98
LEU A 122
 None
 0.96A 2bfpC-3bydA:
undetectable		 2bfpC-3bydA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7j TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF00392
(GntR)
PF07729
(FCD) 		4 PHE A  56
LEU A  14
LEU A  47
LEU A  67
 None
 0.86A 2bfpC-3c7jA:
undetectable		 2bfpC-3c7jA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPI
PSEUDOPILIN GSPK

(Escherichia
coli) 		PF02501
(T2SSI)
PF03934
(T2SSK) 		4 SER K  49
PHE I 112
TYR I  52
LEU I  81
 None
 0.76A 2bfpC-3ci0K:
undetectable		 2bfpC-3ci0K:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ARG A2324
LEU A2075
LEU A2056
LEU A2051
 None
 0.93A 2bfpC-3cmtA:
undetectable		 2bfpC-3cmtA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ARG A3324
LEU A3075
LEU A3056
LEU A3051
 None
 0.98A 2bfpC-3cmtA:
undetectable		 2bfpC-3cmtA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 SER A 156
PHE A 158
LEU A 198
LEU A 232
 None
 0.91A 2bfpC-3d1jA:
undetectable		 2bfpC-3d1jA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkq PKHD-TYPE
HYDROXYLASE
SBAL_3634

(Shewanella
baltica) 		PF13640
(2OG-FeII_Oxy_3) 		4 ARG A 110
LEU A 218
LEU A 224
LEU A  77
 None
 0.80A 2bfpC-3dkqA:
undetectable		 2bfpC-3dkqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkx REPLICATION PROTEIN
REPB

(Streptococcus
agalactiae) 		PF01719
(Rep_2) 		4 PHE A  11
LEU A  13
LEU A  78
LEU A  29
 None
 1.00A 2bfpC-3dkxA:
undetectable		 2bfpC-3dkxA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		4 SER X  50
LEU X  82
LEU X 107
LEU X 112
 None
 0.96A 2bfpC-3du1X:
undetectable		 2bfpC-3du1X:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		4 SER A 136
LEU A   4
LEU A  35
LEU A  11
 None
 0.74A 2bfpC-3ek2A:
25.5		 2bfpC-3ek2A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1) 		no annotation 4 SER A 749
PHE A 747
LEU A 791
LEU A 782
 None
 0.81A 2bfpC-3f95A:
undetectable		 2bfpC-3f95A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE

(Pseudomonas
putida) 		PF00180
(Iso_dh) 		4 ASP X 250
LEU X  90
TYR X 141
LEU X 280
 NAI  X 401 ( 4.5A)
None
None
None
 1.00A 2bfpC-3fmxX:
2.7		 2bfpC-3fmxX:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd9 LAMINARIPENTAOSE-PRO
DUCING
BETA-1,3-GULUASE
(LPHASE)

(Streptomyces
matensis) 		PF16483
(Glyco_hydro_64) 		4 ARG A 318
PHE A 284
LEU A 260
LEU A 310
 None
 0.90A 2bfpC-3gd9A:
undetectable		 2bfpC-3gd9A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III

(Burkholderia
pseudomallei) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 171
LEU A 328
TYR A 124
LEU A 320
 None
 0.99A 2bfpC-3gweA:
undetectable		 2bfpC-3gweA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxe TRYPTOPHANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		4 PHE A 104
LEU A  65
TYR A  68
LEU A  46
 None
 0.77A 2bfpC-3jxeA:
undetectable		 2bfpC-3jxeA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Coxiella
burnetii) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 PHE A 174
LEU A  20
LEU A 165
LEU A 154
 None
 0.96A 2bfpC-3k96A:
undetectable		 2bfpC-3k96A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ka7 OXIDOREDUCTASE

(Methanosarcina
mazei) 		PF01593
(Amino_oxidase) 		5 SER A  51
PHE A  39
LEU A  57
LEU A  14
LEU A 202
 None
 1.48A 2bfpC-3ka7A:
undetectable		 2bfpC-3ka7A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 SER A 827
LEU A 750
LEU A 822
LEU A 777
 ADP  A2101 ( 4.4A)
None
None
None
 0.84A 2bfpC-3lj0A:
undetectable		 2bfpC-3lj0A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llc PUTATIVE HYDROLASE

(Agrobacterium
vitis) 		PF12697
(Abhydrolase_6) 		4 SER A  79
PHE A  71
LEU A  42
LEU A  92
 None
 0.95A 2bfpC-3llcA:
3.6		 2bfpC-3llcA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly5 ATP-DEPENDENT RNA
HELICASE DDX18

(Homo sapiens) 		PF00270
(DEAD) 		4 PHE A 322
LEU A 312
LEU A 354
LEU A 327
 None
 0.88A 2bfpC-3ly5A:
2.4		 2bfpC-3ly5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		4 SER A 164
LEU A 405
LEU A 469
LEU A 471
 None
 0.92A 2bfpC-3mcaA:
undetectable		 2bfpC-3mcaA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		4 SER A 441
LEU A 471
LEU A 407
LEU A 405
 None
 0.99A 2bfpC-3mcaA:
undetectable		 2bfpC-3mcaA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnm ADP-RIBOSYLATION
FACTOR-BINDING
PROTEIN GGA2

(Saccharomyces
cerevisiae) 		PF02883
(Alpha_adaptinC2) 		4 SER A 521
LEU A 582
LEU A 516
LEU A 526
 None
None
None
MLY  A 525 ( 4.0A)
 1.00A 2bfpC-3mnmA:
undetectable		 2bfpC-3mnmA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0g ISOPRENE SYNTHASE

(Populus tremula
x Populus alba) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ARG A 249
SER A 282
LEU A 272
LEU A 119
 None
 0.90A 2bfpC-3n0gA:
undetectable		 2bfpC-3n0gA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n93 MALTOSE BINDING
PROTEIN-CRFR2 ALPHA

(Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 ASP A  45
TYR A  95
LEU A  10
LEU A   6
 None
 0.98A 2bfpC-3n93A:
undetectable		 2bfpC-3n93A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 SER B 368
PHE B 365
LEU B 348
LEU B 334
 None
 1.00A 2bfpC-3ns1B:
undetectable		 2bfpC-3ns1B:
20.48