SIMILAR PATTERNS OF AMINO ACIDS FOR 2BFP_B_H4BB1290

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a88 CHLOROPEROXIDASE L

(Streptomyces
lividans)
PF00561
(Abhydrolase_1)
4 SER A  46
PHE A  44
LEU A 265
LEU A 258
None
0.92A 2bfpB-1a88A:
5.2
2bfpB-1a88A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihm CAPSID PROTEIN

(Norwalk virus)
PF00915
(Calici_coat)
PF08435
(Calici_coat_C)
4 SER A1244
PHE A1421
LEU A1481
LEU A1233
None
0.98A 2bfpB-1ihmA:
undetectable
2bfpB-1ihmA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE


(Pyrococcus
horikoshii)
PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2)
4 SER A  96
PHE A 128
LEU A 184
LEU A 146
G  D 915 ( 4.2A)
None
None
None
0.94A 2bfpB-1j2bA:
undetectable
2bfpB-1j2bA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j85 YIBK

(Haemophilus
influenzae)
PF00588
(SpoU_methylase)
4 PHE A  54
LEU A  44
LEU A  31
LEU A  29
None
0.94A 2bfpB-1j85A:
2.5
2bfpB-1j85A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24


(Saccharomyces
cerevisiae)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
5 SER B 316
PHE B 422
LEU B 309
LEU B 499
LEU B 512
None
1.33A 2bfpB-1m2vB:
2.3
2bfpB-1m2vB:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw5 HYPOTHETICAL PROTEIN
HI1480


(Haemophilus
influenzae)
no annotation 5 SER A 130
PHE A 131
LEU A  73
LEU A  92
LEU A  96
None
1.37A 2bfpB-1mw5A:
undetectable
2bfpB-1mw5A:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mxf PTERIDINE REDUCTASE
2


(Trypanosoma
cruzi)
PF13561
(adh_short_C2)
5 ARG A  22
SER A 103
ASP A 169
LEU A 176
TYR A 182
NDP  A1277 ( 3.9A)
MTX  A1278 ( 2.7A)
NDP  A1277 (-3.9A)
MTX  A1278 (-4.5A)
MTX  A1278 ( 4.7A)
0.38A 2bfpB-1mxfA:
40.2
2bfpB-1mxfA:
48.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mxf PTERIDINE REDUCTASE
2


(Trypanosoma
cruzi)
PF13561
(adh_short_C2)
5 ARG A  22
SER A 103
ASP A 169
TYR A 182
LEU A 214
NDP  A1277 ( 3.9A)
MTX  A1278 ( 2.7A)
NDP  A1277 (-3.9A)
MTX  A1278 ( 4.7A)
MTX  A1278 (-4.4A)
0.68A 2bfpB-1mxfA:
40.2
2bfpB-1mxfA:
48.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mxf PTERIDINE REDUCTASE
2


(Trypanosoma
cruzi)
PF13561
(adh_short_C2)
5 ARG A  22
SER A 103
ASP A 169
TYR A 182
LEU A 217
NDP  A1277 ( 3.9A)
MTX  A1278 ( 2.7A)
NDP  A1277 (-3.9A)
MTX  A1278 ( 4.7A)
None
0.68A 2bfpB-1mxfA:
40.2
2bfpB-1mxfA:
48.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mxf PTERIDINE REDUCTASE
2


(Trypanosoma
cruzi)
PF13561
(adh_short_C2)
4 SER A 103
LEU A 176
TYR A 182
LEU A 214
MTX  A1278 ( 2.7A)
MTX  A1278 (-4.5A)
MTX  A1278 ( 4.7A)
MTX  A1278 (-4.4A)
0.93A 2bfpB-1mxfA:
40.2
2bfpB-1mxfA:
48.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158


(Thermotoga
maritima)
PF00117
(GATase)
4 PHE A 125
LEU A 170
LEU A 217
LEU A 221
None
0.97A 2bfpB-1o1yA:
3.7
2bfpB-1o1yA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogq POLYGALACTURONASE
INHIBITING PROTEIN


(Phaseolus
vulgaris)
PF08263
(LRRNT_2)
4 PHE A 217
LEU A 251
LEU A 260
LEU A 264
None
0.95A 2bfpB-1ogqA:
undetectable
2bfpB-1ogqA:
23.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p33 PTERIDINE REDUCTASE
1


(Leishmania
tarentolae)
PF13561
(adh_short_C2)
7 ARG A  17
SER A 111
PHE A 113
ASP A 181
LEU A 188
TYR A 194
LEU A 226
NDP  A 300 ( 3.7A)
MTX  A 351 ( 2.8A)
MTX  A 351 (-3.5A)
NDP  A 300 ( 3.7A)
MTX  A 351 (-4.5A)
MTX  A 351 ( 4.4A)
MTX  A 351 ( 4.4A)
0.37A 2bfpB-1p33A:
44.4
2bfpB-1p33A:
80.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p33 PTERIDINE REDUCTASE
1


(Leishmania
tarentolae)
PF13561
(adh_short_C2)
6 ARG A  17
SER A 111
PHE A 113
ASP A 181
TYR A 194
LEU A 229
NDP  A 300 ( 3.7A)
MTX  A 351 ( 2.8A)
MTX  A 351 (-3.5A)
NDP  A 300 ( 3.7A)
MTX  A 351 ( 4.4A)
MTX  A 351 (-4.9A)
0.60A 2bfpB-1p33A:
44.4
2bfpB-1p33A:
80.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p33 PTERIDINE REDUCTASE
1


(Leishmania
tarentolae)
PF13561
(adh_short_C2)
5 SER A 111
PHE A 113
LEU A 188
TYR A 194
LEU A 226
MTX  A 351 ( 2.8A)
MTX  A 351 (-3.5A)
MTX  A 351 (-4.5A)
MTX  A 351 ( 4.4A)
MTX  A 351 ( 4.4A)
0.77A 2bfpB-1p33A:
44.4
2bfpB-1p33A:
80.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24


(Saccharomyces
cerevisiae)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
5 SER A 316
PHE A 422
LEU A 309
LEU A 499
LEU A 512
None
1.28A 2bfpB-1pd1A:
2.2
2bfpB-1pd1A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pf5 HYPOTHETICAL PROTEIN
YJGH


(Escherichia
coli)
PF01042
(Ribonuc_L-PSP)
5 SER A 100
PHE A  99
ASP A  72
LEU A  64
LEU A  60
None
1.41A 2bfpB-1pf5A:
undetectable
2bfpB-1pf5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvh LEUKEMIA INHIBITORY
FACTOR


(Homo sapiens)
PF01291
(LIF_OSM)
4 PHE B  67
LEU B  90
TYR B  89
LEU B 166
None
1.00A 2bfpB-1pvhB:
undetectable
2bfpB-1pvhB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1


(Homo sapiens)
PF00575
(S1)
PF07541
(EIF_2_alpha)
4 PHE A 152
LEU A 111
LEU A 167
LEU A 165
None
0.97A 2bfpB-1q8kA:
undetectable
2bfpB-1q8kA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE


(Mycobacterium
tuberculosis)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
4 ASP A  80
LEU A   3
LEU A 114
LEU A 110
None
0.93A 2bfpB-1qpoA:
undetectable
2bfpB-1qpoA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5t DIHYDRODIPICOLINATE
SYNTHASE


(Escherichia
coli)
PF00701
(DHDPS)
4 SER A  34
LEU A 259
TYR A  30
LEU A 239
None
0.96A 2bfpB-1s5tA:
undetectable
2bfpB-1s5tA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfn CONSERVED
HYPOTHETICAL PROTEIN


(Deinococcus
radiodurans)
PF05899
(Cupin_3)
4 PHE A1172
LEU A1178
LEU A1236
LEU A1190
None
0.99A 2bfpB-1sfnA:
undetectable
2bfpB-1sfnA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT


(Saccharomyces
cerevisiae)
PF00004
(AAA)
PF08542
(Rep_fac_C)
4 SER D 323
LEU C 299
LEU C 248
LEU C 252
None
0.96A 2bfpB-1sxjD:
undetectable
2bfpB-1sxjD:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tfd TRANSFERRIN

(Oryctolagus
cuniculus)
PF00405
(Transferrin)
4 SER A 189
PHE A 186
LEU A  62
LEU A  66
None
1.00A 2bfpB-1tfdA:
undetectable
2bfpB-1tfdA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1


(Petroselinum
crispum)
PF00221
(Lyase_aromatic)
4 ARG A 546
PHE A 622
LEU A 593
LEU A 630
None
0.96A 2bfpB-1w27A:
undetectable
2bfpB-1w27A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6v EMP46P

(Saccharomyces
cerevisiae)
PF03388
(Lectin_leg-like)
5 SER A 196
PHE A 192
LEU A 132
LEU A 175
LEU A 165
None
1.49A 2bfpB-2a6vA:
undetectable
2bfpB-2a6vA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT


(Chlamydia
trachomatis)
PF00268
(Ribonuc_red_sm)
4 PHE A 233
LEU A 113
TYR A 112
LEU A 185
None
0.97A 2bfpB-2aniA:
undetectable
2bfpB-2aniA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2c SPERMIDINE SYNTHASE

(Caenorhabditis
elegans)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
4 PHE A 238
LEU A 235
LEU A 218
LEU A 208
None
0.98A 2bfpB-2b2cA:
4.8
2bfpB-2b2cA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE


(Vitis vinifera)
PF00201
(UDPGT)
4 SER A 439
PHE A 222
LEU A 425
LEU A 356
None
0.94A 2bfpB-2c1zA:
5.1
2bfpB-2c1zA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7i PUTATIVE LIPOATE
PROTEIN LIGASE


(Thermoplasma
acidophilum)
PF03099
(BPL_LplA_LipB)
4 SER A  17
LEU A  86
LEU A  36
LEU A   5
None
0.89A 2bfpB-2c7iA:
undetectable
2bfpB-2c7iA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cv6 SEED STORAGE PROTEIN

(Vigna radiata)
PF00190
(Cupin_1)
4 SER A 146
PHE A 144
LEU A  35
LEU A 116
None
0.97A 2bfpB-2cv6A:
undetectable
2bfpB-2cv6A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII


(Thermococcus
kodakarensis)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing)
4 PHE A 363
LEU A 278
LEU A 137
LEU A 140
None
0.99A 2bfpB-2cw7A:
undetectable
2bfpB-2cw7A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fck RIBOSOMAL-PROTEIN-SE
RINE
ACETYLTRANSFERASE,
PUTATIVE


(Vibrio cholerae)
PF13302
(Acetyltransf_3)
4 PHE A  89
LEU A 127
LEU A 132
LEU A  98
NO3  A 310 ( 3.7A)
NO3  A 310 ( 4.5A)
None
None
0.94A 2bfpB-2fckA:
undetectable
2bfpB-2fckA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE


(Pyrococcus
furiosus)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
4 PHE A  22
TYR A  21
LEU A 106
LEU A 105
None
0.97A 2bfpB-2i14A:
undetectable
2bfpB-2i14A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3d HYPOTHETICAL PROTEIN
ATU1826


(Agrobacterium
fabrum)
PF02129
(Peptidase_S15)
4 SER A  71
PHE A  63
LEU A  31
LEU A  82
None
0.91A 2bfpB-2i3dA:
6.6
2bfpB-2i3dA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2


(Saccharomyces
cerevisiae)
PF03095
(PTPA)
5 SER A  49
PHE A 152
LEU A 143
LEU A  59
LEU A  58
None
1.20A 2bfpB-2ixnA:
undetectable
2bfpB-2ixnA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2


(Saccharomyces
cerevisiae)
PF03095
(PTPA)
5 SER A 106
PHE A 104
LEU A  58
LEU A 142
LEU A 143
None
1.37A 2bfpB-2ixnA:
undetectable
2bfpB-2ixnA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2msk NITROGEN REGULATION
PROTEIN NR(I)


(Salmonella
enterica)
PF00072
(Response_reg)
4 PHE A 106
ASP A  10
LEU A  52
LEU A  23
None
0.95A 2bfpB-2mskA:
undetectable
2bfpB-2mskA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o01 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLAST


(Spinacia
oleracea)
PF02605
(PsaL)
4 PHE L 143
LEU L  95
LEU L  64
LEU L  63
None
None
None
CLA  L1502 (-4.2A)
1.01A 2bfpB-2o01L:
undetectable
2bfpB-2o01L:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E)
PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C)
4 ARG A 656
SER A 861
LEU A 353
LEU A 627
MPD  A1706 (-3.6A)
None
None
None
1.00A 2bfpB-2obeA:
undetectable
2bfpB-2obeA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE


(Thermus
thermophilus)
PF00701
(DHDPS)
4 SER A 263
PHE A 269
LEU A 229
LEU A 248
None
0.98A 2bfpB-2pcqA:
undetectable
2bfpB-2pcqA:
24.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhx PTERIDINE REDUCTASE
1


(Leishmania
major)
PF00106
(adh_short)
PF13561
(adh_short_C2)
8 ARG A  17
SER A 111
PHE A 113
ASP A 181
LEU A 188
TYR A 194
LEU A 226
LEU A 229
NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
None
0.34A 2bfpB-2qhxA:
46.4
2bfpB-2qhxA:
87.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhx PTERIDINE REDUCTASE
1


(Leishmania
major)
PF00106
(adh_short)
PF13561
(adh_short_C2)
5 SER A 111
PHE A 113
LEU A 188
TYR A 194
LEU A 226
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
FE1  A1301 (-4.5A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
0.80A 2bfpB-2qhxA:
46.4
2bfpB-2qhxA:
87.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uy3 ENDOCHITINASE

(Saccharomyces
cerevisiae)
PF00704
(Glyco_hydro_18)
4 PHE A  71
LEU A 105
LEU A  67
LEU A  83
None
0.94A 2bfpB-2uy3A:
3.5
2bfpB-2uy3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc6 DIHYDRODIPICOLINATE
SYNTHASE


(Sinorhizobium
meliloti)
PF00701
(DHDPS)
4 SER A  35
LEU A 256
LEU A 243
LEU A 239
None
0.99A 2bfpB-2vc6A:
2.9
2bfpB-2vc6A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III


(Cinnamomum
camphora)
PF00161
(RIP)
PF00652
(Ricin_B_lectin)
4 SER A 146
LEU A  67
TYR A  79
LEU A 136
None
0.97A 2bfpB-2vlcA:
undetectable
2bfpB-2vlcA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN


(Thermus
thermophilus)
PF14589
(NrfD_2)
4 SER C 169
LEU C  37
LEU C 157
LEU C 179
None
0.78A 2bfpB-2vpwC:
undetectable
2bfpB-2vpwC:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN


(Nostoc
punctiforme)
PF00350
(Dynamin_N)
4 ARG A 299
SER A 292
LEU A 205
LEU A 171
None
GDP  A1696 (-4.6A)
None
None
0.97A 2bfpB-2w6dA:
undetectable
2bfpB-2w6dA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqw INTERNALIN B

(Listeria
monocytogenes)
PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
5 SER A  49
PHE A  53
LEU A 105
LEU A 116
LEU A 119
None
1.41A 2bfpB-2wqwA:
undetectable
2bfpB-2wqwA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLASTIC


(Spinacia
oleracea)
PF02605
(PsaL)
4 PHE L 143
LEU L  95
LEU L  64
LEU L  63
None
BCR  L1169 ( 3.8A)
None
None
1.00A 2bfpB-2wscL:
undetectable
2bfpB-2wscL:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1


(Schizosaccharomyces
pombe)
PF10471
(ANAPC_CDC26)
PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12)
4 SER A 399
PHE A 396
LEU B   3
LEU A 358
None
0.91A 2bfpB-2xpiA:
undetectable
2bfpB-2xpiA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens)
PF03810
(IBN_N)
PF08389
(Xpo1)
4 SER B 517
LEU B 535
LEU B 590
LEU B 594
None
1.01A 2bfpB-2xwuB:
undetectable
2bfpB-2xwuB:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5q INTERNALIN B

(Listeria
monocytogenes)
PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
5 SER A  49
PHE A  53
LEU A 105
LEU A 116
LEU A 119
None
1.41A 2bfpB-2y5qA:
undetectable
2bfpB-2y5qA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B


(Eptatretus
burgeri;
Homo sapiens)
PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8)
4 PHE A 165
LEU A 195
LEU A 231
LEU A 233
None
0.92A 2bfpB-2z65A:
undetectable
2bfpB-2z65A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z80 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B


(Eptatretus
burgeri;
Homo sapiens)
PF11921
(DUF3439)
PF13855
(LRR_8)
4 PHE A 162
LEU A 139
LEU A 154
LEU A 179
None
0.94A 2bfpB-2z80A:
undetectable
2bfpB-2z80A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B


(Eptatretus
burgeri;
Mus musculus)
PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 PHE A 162
LEU A 139
LEU A 154
LEU A 179
None
0.94A 2bfpB-2z81A:
undetectable
2bfpB-2z81A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E


(Thermus
thermophilus)
PF00590
(TP_methylase)
4 SER A  81
LEU A  61
LEU A 158
LEU A 157
None
0.96A 2bfpB-2zvbA:
undetectable
2bfpB-2zvbA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3u MENAQUINONE
BIOSYNTHETIC ENZYME


(Thermus
thermophilus)
PF02621
(VitK2_biosynth)
4 SER A  73
LEU A  32
LEU A 189
LEU A 185
None
0.95A 2bfpB-3a3uA:
undetectable
2bfpB-3a3uA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7k HALORHODOPSIN

(Natronomonas
pharaonis)
PF01036
(Bac_rhodopsin)
4 ARG A 176
TYR A 248
LEU A 164
LEU A 168
None
0.97A 2bfpB-3a7kA:
undetectable
2bfpB-3a7kA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pyrobaculum
aerophilum)
PF07995
(GSDH)
4 PHE A  82
LEU A 136
LEU A  60
LEU A  95
None
0.96A 2bfpB-3a9gA:
undetectable
2bfpB-3a9gA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like)
4 SER A 117
ASP A 152
LEU A 169
LEU A 174
None
0.94A 2bfpB-3abzA:
undetectable
2bfpB-3abzA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agb RED CHLOROPHYLL
CATABOLITE
REDUCTASE,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF06405
(RCC_reductase)
4 PHE A 151
LEU A  69
LEU A 155
LEU A 165
None
0.92A 2bfpB-3agbA:
undetectable
2bfpB-3agbA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C


(Sulfurisphaera
tokodaii)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
4 SER C 188
LEU C 165
LEU C 225
LEU C 227
None
0.99A 2bfpB-3aizC:
undetectable
2bfpB-3aizC:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay0 UNCHARACTERIZED
PROTEIN MJ0883


(Methanocaldococcus
jannaschii)
PF02475
(Met_10)
4 ARG A 323
SER A 319
LEU A  19
LEU A  60
None
0.96A 2bfpB-3ay0A:
undetectable
2bfpB-3ay0A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens)
PF00560
(LRR_1)
PF13855
(LRR_8)
4 PHE A 166
LEU A 156
LEU A 151
LEU A 148
None
0.89A 2bfpB-3b2dA:
undetectable
2bfpB-3b2dA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byd BETA-LACTAMASE OXY-1

(Klebsiella
oxytoca)
PF13354
(Beta-lactamase2)
4 SER A 109
ASP A 104
LEU A  98
LEU A 122
None
1.01A 2bfpB-3bydA:
undetectable
2bfpB-3bydA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
4 SER A 156
PHE A 158
LEU A 198
LEU A 232
None
0.90A 2bfpB-3d1jA:
undetectable
2bfpB-3d1jA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM


(Homo sapiens)
no annotation 4 SER B 289
PHE B 346
LEU B 336
LEU B 329
None
0.95A 2bfpB-3dw8B:
undetectable
2bfpB-3dw8B:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)


(Burkholderia
pseudomallei)
PF13561
(adh_short_C2)
4 SER A 136
LEU A   4
LEU A  35
LEU A  11
None
0.71A 2bfpB-3ek2A:
25.6
2bfpB-3ek2A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1)
no annotation 4 SER A 749
PHE A 747
LEU A 791
LEU A 782
None
0.83A 2bfpB-3f95A:
undetectable
2bfpB-3f95A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1)
no annotation 4 SER A 749
PHE A 747
LEU A 791
LEU A 782
None
0.96A 2bfpB-3f95A:
undetectable
2bfpB-3f95A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III


(Burkholderia
pseudomallei)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 SER A 171
LEU A 328
TYR A 124
LEU A 320
None
0.89A 2bfpB-3gweA:
undetectable
2bfpB-3gweA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III


(Burkholderia
pseudomallei)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 SER A 171
LEU A 328
TYR A 124
LEU A 320
None
0.99A 2bfpB-3gweA:
undetectable
2bfpB-3gweA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128


(Homo sapiens)
PF02225
(PA)
4 SER A  75
LEU A  47
LEU A  84
LEU A 119
None
0.93A 2bfpB-3icuA:
undetectable
2bfpB-3icuA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens)
PF01582
(TIR)
PF13855
(LRR_8)
4 SER A 542
LEU A 504
LEU A 528
LEU A 525
None
0.97A 2bfpB-3j0aA:
undetectable
2bfpB-3j0aA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxe TRYPTOPHANYL-TRNA
SYNTHETASE


(Pyrococcus
horikoshii)
PF00579
(tRNA-synt_1b)
4 PHE A 104
LEU A  65
TYR A  68
LEU A  46
None
0.79A 2bfpB-3jxeA:
3.5
2bfpB-3jxeA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2


(Bacillus
anthracis)
PF00202
(Aminotran_3)
4 SER A 375
PHE A 361
LEU A 402
LEU A 394
None
0.97A 2bfpB-3k28A:
undetectable
2bfpB-3k28A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]


(Coxiella
burnetii)
PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C)
4 PHE A 174
LEU A  20
LEU A 165
LEU A 154
None
0.99A 2bfpB-3k96A:
6.6
2bfpB-3k96A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llc PUTATIVE HYDROLASE

(Agrobacterium
vitis)
PF12697
(Abhydrolase_6)
5 SER A  79
PHE A  71
LEU A  42
LEU A  92
LEU A  96
None
1.14A 2bfpB-3llcA:
undetectable
2bfpB-3llcA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly5 ATP-DEPENDENT RNA
HELICASE DDX18


(Homo sapiens)
PF00270
(DEAD)
4 PHE A 322
LEU A 312
LEU A 354
LEU A 327
None
0.64A 2bfpB-3ly5A:
2.8
2bfpB-3ly5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN


(Enterococcus
faecium)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI)
4 PHE A 175
LEU A 132
LEU A 362
LEU A 365
None
1.00A 2bfpB-3m4xA:
6.1
2bfpB-3m4xA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4p TERMINASE SUBUNIT
UL89 PROTEIN


(Human
betaherpesvirus
5)
PF02499
(DNA_pack_C)
4 ASP A 615
LEU A 605
LEU A 620
LEU A 652
None
0.97A 2bfpB-3n4pA:
undetectable
2bfpB-3n4pA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE GAMMA-SUBUNIT


(Komagataella
pastoris)
no annotation 4 ARG I 300
PHE I 289
LEU I 245
LEU I 269
None
1.00A 2bfpB-3opyI:
2.6
2bfpB-3opyI:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov5 UNCHARACTERIZED
PROTEIN


(Xanthomonas
citri)
PF10671
(TcpQ)
4 ASP A  86
LEU A  68
TYR A  81
LEU A  89
None
0.99A 2bfpB-3ov5A:
undetectable
2bfpB-3ov5A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1t PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Burkholderia
pseudomallei)
PF00155
(Aminotran_1_2)
4 PHE A 195
LEU A 240
TYR A 199
LEU A  70
None
0.81A 2bfpB-3p1tA:
undetectable
2bfpB-3p1tA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps0 CRISPR-ASSOCIATED
PROTEIN, CSA2


(Sulfolobus
solfataricus)
PF01905
(DevR)
4 SER A  60
TYR A  57
LEU A 318
LEU A 314
None
0.87A 2bfpB-3ps0A:
undetectable
2bfpB-3ps0A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8d DNA REPAIR PROTEIN
RECO


(Escherichia
coli)
PF02565
(RecO_C)
PF11967
(RecO_N)
4 ARG A 194
PHE A 134
LEU A  96
LEU A 142
None
0.97A 2bfpB-3q8dA:
undetectable
2bfpB-3q8dA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpx FAB C2507 HEAVY
CHAIN


(Homo sapiens;
Rattus
norvegicus)
PF07654
(C1-set)
PF07686
(V-set)
4 SER H  61
PHE H  68
LEU H  86
LEU H  20
None
0.99A 2bfpB-3qpxH:
undetectable
2bfpB-3qpxH:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus)
PF00560
(LRR_1)
PF13855
(LRR_8)
4 SER A 195
LEU A 156
LEU A 151
LEU A 148
None
0.88A 2bfpB-3rg1A:
undetectable
2bfpB-3rg1A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus)
PF13855
(LRR_8)
4 PHE A 344
LEU A 317
LEU A 310
LEU A 305
None
1.00A 2bfpB-3t6qA:
undetectable
2bfpB-3t6qA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkn NUCLEOPORIN NUP82

(Saccharomyces
cerevisiae)
no annotation 4 LEU A 294
TYR A 295
LEU A 350
LEU A 327
None
0.96A 2bfpB-3tknA:
undetectable
2bfpB-3tknA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqt D-ALANINE--D-ALANINE
LIGASE


(Coxiella
burnetii)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
4 SER A 135
LEU A  10
LEU A 125
LEU A 123
None
0.93A 2bfpB-3tqtA:
undetectable
2bfpB-3tqtA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B


(Homo sapiens)
PF02141
(DENN)
PF03455
(dDENN)
PF03456
(uDENN)
4 SER A 321
PHE A 319
LEU A 359
LEU A 284
None
0.83A 2bfpB-3tw8A:
undetectable
2bfpB-3tw8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2p RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4


(Homo sapiens)
PF00757
(Furin-like)
PF01030
(Recep_L_domain)
4 PHE A  51
LEU A  24
LEU A  72
LEU A  74
None
0.85A 2bfpB-3u2pA:
undetectable
2bfpB-3u2pA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4


(Homo sapiens)
PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV)
4 PHE A  51
LEU A  24
LEU A  72
LEU A  74
None
0.89A 2bfpB-3u7uA:
undetectable
2bfpB-3u7uA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B


(Homo sapiens;
Mus musculus;
Rattus
norvegicus)
PF02828
(L27)
PF09045
(L27_2)
PF09060
(L27_N)
4 PHE A 117
LEU A  42
LEU A 108
LEU A  89
None
0.97A 2bfpB-3uitA:
undetectable
2bfpB-3uitA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukn NOVEL PROTEIN
SIMILAR TO
VERTEBRATE POTASSIUM
VOLTAGE-GATED
CHANNEL, SUBFAMILY H
(EAG-RELATED) FAMILY


(Danio rerio)
PF00027
(cNMP_binding)
4 PHE A 730
LEU A 688
LEU A 738
LEU A 682
None
0.98A 2bfpB-3uknA:
undetectable
2bfpB-3uknA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v44 TOLL-LIKE RECEPTOR
5B AND VARIABLE
LYMPHOCYTE RECEPTOR
B.61 CHIMERIC
PROTEIN


(Danio rerio;
Eptatretus
burgeri)
PF11921
(DUF3439)
PF13855
(LRR_8)
5 SER A  66
PHE A  92
LEU A 101
LEU A 109
LEU A 111
None
1.46A 2bfpB-3v44A:
undetectable
2bfpB-3v44A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC


(Dictyostelium
discoideum)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
4 ARG A3767
SER A3912
LEU A4133
LEU A4204
None
0.95A 2bfpB-3vkgA:
undetectable
2bfpB-3vkgA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC


(Dictyostelium
discoideum)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
4 PHE A2538
TYR A2430
LEU A2577
LEU A2581
None
0.96A 2bfpB-3vkgA:
undetectable
2bfpB-3vkgA:
6.85