SIMILAR PATTERNS OF AMINO ACIDS FOR 2BFP_A_H4BA1290_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihm CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 SER A1244
PHE A1421
LEU A1481
LEU A1233
 None
 0.99A 2bfpA-1ihmA:
undetectable		 2bfpA-1ihmA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		5 ARG A  22
SER A 103
ASP A 169
LEU A 176
TYR A 182
 NDP  A1277 ( 3.9A)
MTX  A1278 ( 2.7A)
NDP  A1277 (-3.9A)
MTX  A1278 (-4.5A)
MTX  A1278 ( 4.7A)
 0.36A 2bfpA-1mxfA:
40.2		 2bfpA-1mxfA:
48.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		4 SER A 103
LEU A 176
TYR A 182
LEU A 214
 MTX  A1278 ( 2.7A)
MTX  A1278 (-4.5A)
MTX  A1278 ( 4.7A)
MTX  A1278 (-4.4A)
 0.95A 2bfpA-1mxfA:
40.2		 2bfpA-1mxfA:
48.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158

(Thermotoga
maritima) 		PF00117
(GATase) 		4 PHE A 125
LEU A 170
LEU A 217
LEU A 221
 None
 0.95A 2bfpA-1o1yA:
3.9		 2bfpA-1o1yA:
18.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p33 PTERIDINE REDUCTASE
1

(Leishmania
tarentolae) 		PF13561
(adh_short_C2) 		7 ARG A  17
SER A 111
PHE A 113
ASP A 181
LEU A 188
TYR A 194
LEU A 226
 NDP  A 300 ( 3.7A)
MTX  A 351 ( 2.8A)
MTX  A 351 (-3.5A)
NDP  A 300 ( 3.7A)
MTX  A 351 (-4.5A)
MTX  A 351 ( 4.4A)
MTX  A 351 ( 4.4A)
 0.38A 2bfpA-1p33A:
44.3		 2bfpA-1p33A:
80.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p33 PTERIDINE REDUCTASE
1

(Leishmania
tarentolae) 		PF13561
(adh_short_C2) 		6 ARG A  17
SER A 111
PHE A 113
ASP A 181
TYR A 194
LEU A 229
 NDP  A 300 ( 3.7A)
MTX  A 351 ( 2.8A)
MTX  A 351 (-3.5A)
NDP  A 300 ( 3.7A)
MTX  A 351 ( 4.4A)
MTX  A 351 (-4.9A)
 0.56A 2bfpA-1p33A:
44.3		 2bfpA-1p33A:
80.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p33 PTERIDINE REDUCTASE
1

(Leishmania
tarentolae) 		PF13561
(adh_short_C2) 		4 SER A 111
PHE A 113
TYR A 194
LEU A 226
 MTX  A 351 ( 2.8A)
MTX  A 351 (-3.5A)
MTX  A 351 ( 4.4A)
MTX  A 351 ( 4.4A)
 0.74A 2bfpA-1p33A:
44.3		 2bfpA-1p33A:
80.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1

(Homo sapiens) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		4 PHE A 152
LEU A 111
LEU A 167
LEU A 165
 None
 1.00A 2bfpA-1q8kA:
undetectable		 2bfpA-1q8kA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttw SECRETION CHAPERONE

(Yersinia pestis) 		PF05932
(CesT) 		4 PHE A  11
LEU A 109
LEU A  95
LEU A  48
 None
 1.04A 2bfpA-1ttwA:
undetectable		 2bfpA-1ttwA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		4 ARG A 546
PHE A 622
LEU A 593
LEU A 630
 None
 0.96A 2bfpA-1w27A:
0.0		 2bfpA-1w27A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fck RIBOSOMAL-PROTEIN-SE
RINE
ACETYLTRANSFERASE,
PUTATIVE

(Vibrio cholerae) 		PF13302
(Acetyltransf_3) 		4 PHE A  89
LEU A 127
LEU A 132
LEU A  98
 NO3  A 310 ( 3.7A)
NO3  A 310 ( 4.5A)
None
None
 0.93A 2bfpA-2fckA:
0.6		 2bfpA-2fckA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 PHE A  22
TYR A  21
LEU A 106
LEU A 105
 None
 0.95A 2bfpA-2i14A:
1.2		 2bfpA-2i14A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2msk NITROGEN REGULATION
PROTEIN NR(I)

(Salmonella
enterica) 		PF00072
(Response_reg) 		4 PHE A 106
ASP A  10
LEU A  52
LEU A  23
 None
 0.99A 2bfpA-2mskA:
3.6		 2bfpA-2mskA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 ARG A 656
SER A 861
LEU A 353
LEU A 627
 MPD  A1706 (-3.6A)
None
None
None
 0.97A 2bfpA-2obeA:
undetectable		 2bfpA-2obeA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE

(Thermus
thermophilus) 		PF00701
(DHDPS) 		4 SER A 263
PHE A 269
LEU A 229
LEU A 248
 None
 0.99A 2bfpA-2pcqA:
1.6		 2bfpA-2pcqA:
24.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhx PTERIDINE REDUCTASE
1

(Leishmania
major) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		8 ARG A  17
SER A 111
PHE A 113
ASP A 181
LEU A 188
TYR A 194
LEU A 226
LEU A 229
 NAP  A1300 ( 3.7A)
FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
NAP  A1300 ( 3.6A)
FE1  A1301 (-4.5A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
None
 0.27A 2bfpA-2qhxA:
46.4		 2bfpA-2qhxA:
87.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhx PTERIDINE REDUCTASE
1

(Leishmania
major) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		4 SER A 111
PHE A 113
TYR A 194
LEU A 226
 FE1  A1301 ( 2.8A)
FE1  A1301 (-3.4A)
FE1  A1301 ( 4.5A)
FE1  A1301 ( 4.9A)
 0.76A 2bfpA-2qhxA:
46.4		 2bfpA-2qhxA:
87.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc6 DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		4 SER A  35
LEU A 256
LEU A 243
LEU A 239
 None
 1.00A 2bfpA-2vc6A:
2.8		 2bfpA-2vc6A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus) 		PF14589
(NrfD_2) 		4 SER C 169
LEU C  37
LEU C 157
LEU C 179
 None
 0.75A 2bfpA-2vpwC:
undetectable		 2bfpA-2vpwC:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkk TOPOISOMERASE IV

(Acinetobacter
baumannii) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 SER A1138
LEU A1469
LEU A1189
LEU A1170
 None
 1.01A 2bfpA-2xkkA:
undetectable		 2bfpA-2xkkA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9
ANAPHASE-PROMOTING
COMPLEX SUBUNIT HCN1
HCN1/CDC26,20S
CYCLOSOME/APC
COMPLEX PROTEIN
HCN1, CHAPERONE-LIKE
PROTEIN HCN1, HIGH
COPY SUPPRESSOR OF
CUT9 PROTEIN 1

(Schizosaccharomyces
pombe) 		PF10471
(ANAPC_CDC26)
PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 SER A 399
PHE A 396
LEU B   3
LEU A 358
 None
 0.93A 2bfpA-2xpiA:
undetectable		 2bfpA-2xpiA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 PHE A 165
LEU A 195
LEU A 231
LEU A 233
 None
 0.94A 2bfpA-2z65A:
undetectable		 2bfpA-2z65A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 PHE A 532
LEU A 511
LEU A 525
LEU A 549
 None
 1.00A 2bfpA-2z66A:
undetectable		 2bfpA-2z66A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		4 SER A  81
LEU A  61
LEU A 158
LEU A 157
 None
 0.99A 2bfpA-2zvbA:
undetectable		 2bfpA-2zvbA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3u MENAQUINONE
BIOSYNTHETIC ENZYME

(Thermus
thermophilus) 		PF02621
(VitK2_biosynth) 		4 SER A  73
LEU A  32
LEU A 189
LEU A 185
 None
 0.98A 2bfpA-3a3uA:
undetectable		 2bfpA-3a3uA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7k HALORHODOPSIN

(Natronomonas
pharaonis) 		PF01036
(Bac_rhodopsin) 		4 ARG A 176
TYR A 248
LEU A 164
LEU A 168
 None
 0.96A 2bfpA-3a7kA:
undetectable		 2bfpA-3a7kA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		4 PHE A  82
LEU A 136
LEU A  60
LEU A  95
 None
 0.95A 2bfpA-3a9gA:
undetectable		 2bfpA-3a9gA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 SER C 188
LEU C 165
LEU C 225
LEU C 227
 None
 1.02A 2bfpA-3aizC:
undetectable		 2bfpA-3aizC:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9j XANTHINE OXIDASE

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 SER B 368
PHE B 365
LEU B 348
LEU B 334
 None
 1.03A 2bfpA-3b9jB:
undetectable		 2bfpA-3b9jB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7j TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF00392
(GntR)
PF07729
(FCD) 		4 PHE A  56
LEU A  14
LEU A  47
LEU A  67
 None
 1.04A 2bfpA-3c7jA:
undetectable		 2bfpA-3c7jA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 SER A 156
PHE A 158
LEU A 198
LEU A 232
 None
 0.87A 2bfpA-3d1jA:
undetectable		 2bfpA-3d1jA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM

(Homo sapiens) 		no annotation 4 SER B 289
PHE B 346
LEU B 336
LEU B 329
 None
 0.98A 2bfpA-3dw8B:
undetectable		 2bfpA-3dw8B:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek2 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
(NADH)

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		4 SER A 136
LEU A   4
LEU A  35
LEU A  11
 None
 0.69A 2bfpA-3ek2A:
25.7		 2bfpA-3ek2A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1) 		no annotation 4 SER A 749
PHE A 747
LEU A 791
LEU A 782
 None
 0.81A 2bfpA-3f95A:
undetectable		 2bfpA-3f95A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1) 		no annotation 4 SER A 749
PHE A 747
LEU A 791
LEU A 782
 None
 0.98A 2bfpA-3f95A:
undetectable		 2bfpA-3f95A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PHE A 532
LEU A 511
LEU A 525
LEU A 549
 None
 0.98A 2bfpA-3fxiA:
undetectable		 2bfpA-3fxiA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens) 		PF01582
(TIR)
PF13855
(LRR_8) 		4 SER A 542
LEU A 504
LEU A 528
LEU A 525
 None
 0.99A 2bfpA-3j0aA:
undetectable		 2bfpA-3j0aA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxe TRYPTOPHANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		4 PHE A 104
LEU A  65
TYR A  68
LEU A  46
 None
 0.77A 2bfpA-3jxeA:
undetectable		 2bfpA-3jxeA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 SER A 375
PHE A 361
LEU A 402
LEU A 394
 None
 0.97A 2bfpA-3k28A:
undetectable		 2bfpA-3k28A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3p D-ALANINE--D-ALANINE
LIGASE

(Streptococcus
mutans) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 SER A  26
PHE A 309
LEU A 333
LEU A 324
 None
 1.04A 2bfpA-3k3pA:
undetectable		 2bfpA-3k3pA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE

(Streptococcus
mutans) 		PF01048
(PNP_UDP_1) 		4 PHE A 258
LEU A  28
LEU A  70
LEU A 266
 None
 1.00A 2bfpA-3la8A:
undetectable		 2bfpA-3la8A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 SER A 827
LEU A 750
LEU A 822
LEU A 777
 ADP  A2101 ( 4.4A)
None
None
None
 0.99A 2bfpA-3lj0A:
undetectable		 2bfpA-3lj0A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly5 ATP-DEPENDENT RNA
HELICASE DDX18

(Homo sapiens) 		PF00270
(DEAD) 		4 PHE A 322
LEU A 312
LEU A 354
LEU A 327
 None
 0.69A 2bfpA-3ly5A:
undetectable		 2bfpA-3ly5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN

(Enterococcus
faecium) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		4 PHE A 175
LEU A 132
LEU A 362
LEU A 365
 None
 0.96A 2bfpA-3m4xA:
5.4		 2bfpA-3m4xA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		4 SER A 164
LEU A 405
LEU A 469
LEU A 471
 None
 0.98A 2bfpA-3mcaA:
undetectable		 2bfpA-3mcaA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne7 ACETYLTRANSFERASE

(Thermoplasma
acidophilum) 		PF00583
(Acetyltransf_1) 		4 PHE A 143
LEU A 108
TYR A 138
LEU A  80
 None
None
BME  A 162 ( 4.9A)
BME  A 163 (-4.9A)
 1.05A 2bfpA-3ne7A:
undetectable		 2bfpA-3ne7A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 SER B 368
PHE B 365
LEU B 348
LEU B 334
 None
 1.02A 2bfpA-3ns1B:
undetectable		 2bfpA-3ns1B:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 ARG A 452
ASP A 443
LEU A 137
LEU A 141
 None
 1.02A 2bfpA-3sghA:
undetectable		 2bfpA-3sghA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 PHE A 344
LEU A 317
LEU A 310
LEU A 305
 None
 1.05A 2bfpA-3t6qA:
undetectable		 2bfpA-3t6qA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkn NUCLEOPORIN NUP82

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 294
TYR A 295
LEU A 350
LEU A 327
 None
 0.95A 2bfpA-3tknA:
undetectable		 2bfpA-3tknA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF02141
(DENN)
PF03455
(dDENN)
PF03456
(uDENN) 		4 SER A 321
PHE A 319
LEU A 359
LEU A 284
 None
 0.86A 2bfpA-3tw8A:
undetectable		 2bfpA-3tw8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2p RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 PHE A  51
LEU A  24
LEU A  72
LEU A  74
 None
 0.85A 2bfpA-3u2pA:
undetectable		 2bfpA-3u2pA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 PHE A  51
LEU A  24
LEU A  72
LEU A  74
 None
 0.89A 2bfpA-3u7uA:
undetectable		 2bfpA-3u7uA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ARG A3767
SER A3912
LEU A4133
LEU A4204
 None
 0.93A 2bfpA-3vkgA:
undetectable		 2bfpA-3vkgA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 PHE A2538
TYR A2430
LEU A2577
LEU A2581
 None
 0.95A 2bfpA-3vkgA:
undetectable		 2bfpA-3vkgA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 590
LEU A 550
LEU A 575
LEU A 572
 None
 1.04A 2bfpA-3wpeA:
undetectable		 2bfpA-3wpeA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx5 CELLULASE

(uncultured
bacterium) 		PF01670
(Glyco_hydro_12) 		4 PHE A 254
TYR A  53
LEU A 121
LEU A 214
 None
 1.00A 2bfpA-3wx5A:
undetectable		 2bfpA-3wx5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00155
(Aminotran_1_2) 		4 SER A 172
LEU A 245
LEU A 233
LEU A 237
 None
 0.85A 2bfpA-3wy7A:
undetectable		 2bfpA-3wy7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aal CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 SER A 271
LEU A 196
LEU A 211
LEU A 215
 None
 0.99A 2bfpA-4aalA:
undetectable		 2bfpA-4aalA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1) 		4 PHE B 189
LEU B 169
LEU B  77
LEU B  79
 None
 0.98A 2bfpA-4gmjB:
undetectable		 2bfpA-4gmjB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		4 ARG A 104
SER A 445
PHE A 447
LEU A 409
 None
None
NAD  A 601 (-4.5A)
NAD  A 601 (-4.3A)
 0.94A 2bfpA-4go4A:
3.4		 2bfpA-4go4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huj UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored) 		4 SER A  48
PHE A  20
LEU A 163
LEU A 134
 None
 0.95A 2bfpA-4hujA:
undetectable		 2bfpA-4hujA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jer HEMOPHORE HASA

(Yersinia pestis) 		PF06438
(HasA) 		4 PHE A  92
LEU A 146
LEU A 121
LEU A 119
 None
 0.97A 2bfpA-4jerA:
undetectable		 2bfpA-4jerA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2

(Streptococcus
pyogenes) 		no annotation 4 PHE A 400
ASP A 231
TYR A 117
LEU A 300
 None
 0.87A 2bfpA-4nuzA:
3.1		 2bfpA-4nuzA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 PHE A 201
LEU A 392
LEU A 409
LEU A 295
 None
HEM  A 602 (-4.2A)
HEM  A 602 ( 4.7A)
None
 0.98A 2bfpA-4ph9A:
undetectable		 2bfpA-4ph9A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxa SMALL G PROTEIN
SIGNALING MODULATOR
1

(Mus musculus) 		no annotation 4 PHE B 353
LEU B 278
LEU B 340
LEU B 326
 None
 0.74A 2bfpA-4qxaB:
undetectable		 2bfpA-4qxaB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Homo sapiens) 		PF01704
(UDPGP) 		4 PHE A 446
LEU A 432
TYR A 442
LEU A 455
 None
 0.89A 2bfpA-4r7pA:
undetectable		 2bfpA-4r7pA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdj CAPSID

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 SER A 437
PHE A 439
LEU A 390
LEU A 401
 None
 1.02A 2bfpA-4rdjA:
undetectable		 2bfpA-4rdjA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg1 C9ORF114

(Homo sapiens) 		PF02598
(Methyltrn_RNA_3) 		4 ARG A 265
PHE A 115
LEU A 317
LEU A 308
 None
 1.02A 2bfpA-4rg1A:
undetectable		 2bfpA-4rg1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		4 PHE A 119
LEU A 108
LEU A 154
LEU A 163
 None
 0.89A 2bfpA-4rxlA:
undetectable		 2bfpA-4rxlA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbd BSHC

(Bacillus
subtilis) 		PF10079
(BshC) 		4 ARG A 205
PHE A 213
LEU A  96
LEU A 197
 None
 0.92A 2bfpA-4wbdA:
undetectable		 2bfpA-4wbdA:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wcd PTERIDINE REDUCTASE

(Trypanosoma
brucei) 		PF13561
(adh_short_C2) 		6 ARG A  14
SER A  95
PHE A  97
ASP A 161
TYR A 174
LEU A 209
 NAP  A 301 (-3.7A)
NAP  A 301 ( 3.1A)
3KH  A 302 (-3.5A)
NAP  A 301 ( 3.8A)
3KH  A 302 ( 4.7A)
None
 0.60A 2bfpA-4wcdA:
40.7		 2bfpA-4wcdA:
48.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqi D-ALANINE--D-ALANINE
LIGASE

(Yersinia pestis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 SER A  91
LEU A   8
LEU A  81
LEU A  79
 None
 0.91A 2bfpA-4zqiA:
undetectable		 2bfpA-4zqiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		4 ARG A 104
PHE A 328
LEU A 342
LEU A 389
 None
 1.01A 2bfpA-5ddsA:
undetectable		 2bfpA-5ddsA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Vibrio cholerae) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		4 PHE A 234
LEU A 201
LEU A 251
LEU A 255
 None
 0.93A 2bfpA-5dt9A:
undetectable		 2bfpA-5dt9A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2v GTP
PYROPHOSPHOKINASE
YJBM

(Bacillus
subtilis) 		no annotation 4 ASP V  98
LEU V  20
LEU V  93
LEU V 121
 None
 0.95A 2bfpA-5f2vV:
undetectable		 2bfpA-5f2vV:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8e METHYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF13847
(Methyltransf_31) 		4 SER A 111
LEU A  24
LEU A  94
LEU A  37
 None
 1.02A 2bfpA-5f8eA:
6.7		 2bfpA-5f8eA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmb TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Pseudomonas
aeruginosa) 		PF00588
(SpoU_methylase) 		4 SER A  74
LEU A 101
LEU A   2
LEU A  30
 None
 0.85A 2bfpA-5gmbA:
undetectable		 2bfpA-5gmbA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpl PUTATIVE NUCLEOSOME
ASSEMBLY PROTEIN
C36B7.08C

(Schizosaccharomyces
pombe) 		PF00956
(NAP) 		4 PHE A 165
LEU A  96
LEU A 185
LEU A 181
 None
 0.98A 2bfpA-5gplA:
undetectable		 2bfpA-5gplA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h80 CARBOXYLASE

(Deinococcus
radiodurans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASP A 226
LEU A 444
LEU A 404
LEU A 408
 None
 1.01A 2bfpA-5h80A:
undetectable		 2bfpA-5h80A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 LEU A  56
TYR A 120
LEU A  24
LEU A 239
 None
 0.83A 2bfpA-5hc4A:
4.2		 2bfpA-5hc4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		4 PHE A 363
LEU A 344
LEU A 339
LEU A 336
 None
 0.85A 2bfpA-5hdhA:
undetectable		 2bfpA-5hdhA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 PHE A 492
LEU A 462
LEU A 587
LEU A 583
 None
 1.01A 2bfpA-5i2gA:
undetectable		 2bfpA-5i2gA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ij6 LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		4 PHE A 323
TYR A 287
LEU A 281
LEU A 300
 None
 1.03A 2bfpA-5ij6A:
undetectable		 2bfpA-5ij6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyo CYP101J2

(Sphingobium
yanoikuyae) 		PF00067
(p450) 		4 ARG A 347
PHE A 290
LEU A 266
LEU A 342
 None
 0.97A 2bfpA-5kyoA:
undetectable		 2bfpA-5kyoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l25 BORON TRANSPORTER 1

(Arabidopsis
thaliana) 		PF00955
(HCO3_cotransp) 		4 SER A 125
TYR A 103
LEU A 339
LEU A 136
 None
 0.95A 2bfpA-5l25A:
undetectable		 2bfpA-5l25A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn HEXON PROTEIN,HEXON
CAPSID

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 ARG A 675
SER A 880
LEU A 371
LEU A 646
 None
 0.92A 2bfpA-5ldnA:
undetectable		 2bfpA-5ldnA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx0 FIBROMODULIN

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 329
LEU A 285
LEU A 300
LEU A 298
 None
 1.01A 2bfpA-5mx0A:
undetectable		 2bfpA-5mx0A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myf DUTPASE FROM DI S.
AUREUS PHAGE

(Staphylococcus
aureus) 		no annotation 4 PHE D  92
LEU D   5
LEU D  72
LEU D  76
 None
 0.73A 2bfpA-5myfD:
undetectable		 2bfpA-5myfD:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 4 SER C 186
LEU C 120
LEU C 115
LEU C 139
 None
 0.97A 2bfpA-5o4gC:
undetectable		 2bfpA-5o4gC:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5omm CAPSID PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		4 SER A 240
PHE A 442
LEU A 505
LEU A 229
 None
 0.99A 2bfpA-5ommA:
undetectable		 2bfpA-5ommA:
23.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE

(Brucella suis) 		PF00106
(adh_short) 		5 ARG A  31
SER A 105
PHE A 107
ASP A 155
TYR A 168
 NAP  A 301 (-3.9A)
NAP  A 301 (-3.0A)
None
NAP  A 301 ( 3.8A)
None
 0.50A 2bfpA-5tgdA:
30.5		 2bfpA-5tgdA:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9z PHOSPHOGLYCEROL
TRANSFERASE

(Streptococcus
pyogenes) 		no annotation 4 PHE A 708
ASP A 623
LEU A 683
LEU A 506
 None
 0.98A 2bfpA-5u9zA:
undetectable		 2bfpA-5u9zA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6h PDZ
DOMAIN-CONTAINING
PROTEIN GIPC2

(Mus musculus) 		no annotation 4 PHE A 299
LEU A 254
LEU A 290
LEU A 286
 None
 0.89A 2bfpA-5v6hA:
undetectable		 2bfpA-5v6hA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3h URACIL-DNA
GLYCOSYLASE

(Nitratifractor
salsuginis) 		no annotation 4 SER A 219
LEU A 167
LEU A  31
LEU A  35
 None
 0.91A 2bfpA-5x3hA:
undetectable		 2bfpA-5x3hA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 4 SER D1012
LEU D 986
LEU D1044
LEU D1048
 None
 0.91A 2bfpA-5xbkD:
undetectable		 2bfpA-5xbkD:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfg RAN GUANINE
NUCLEOTIDE RELEASE
FACTOR

(Homo sapiens) 		no annotation 4 SER A  26
ASP A  33
LEU A   9
LEU A  51
 None
 0.95A 2bfpA-5yfgA:
undetectable		 2bfpA-5yfgA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9r HYDROXYETHYLPHOSPHON
ATE DIOXYGENASE

(Streptomyces
albus) 		no annotation 4 PHE A 330
LEU A 358
LEU A 367
LEU A 414
 None
 0.87A 2bfpA-6b9rA:
undetectable		 2bfpA-6b9rA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Oryctolagus
cuniculus) 		no annotation 4 ARG A 700
SER A 345
LEU A 248
LEU A 324
 None
 1.01A 2bfpA-6bwmA:
undetectable		 2bfpA-6bwmA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cud SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 3

(Homo sapiens) 		no annotation 4 PHE A  31
LEU A  47
LEU A  87
LEU A  66
 None
 0.93A 2bfpA-6cudA:
undetectable		 2bfpA-6cudA:
13.40