SIMILAR PATTERNS OF AMINO ACIDS FOR 2B9E_A_SAMA1201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		5 GLY A  54
LEU A 217
ASP A 216
ASP A 169
SER A 192
 None
 1.19A 2b9eA-1e19A:
4.1		 2b9eA-1e19A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		5 PRO A  62
GLY A  63
LEU A  84
ASP A  99
PHE A 100
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.5A)
None
 0.81A 2b9eA-1eizA:
13.1		 2b9eA-1eizA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma) 		PF01593
(Amino_oxidase) 		5 GLY A  87
ASN A  85
LEU A 422
ASP A 423
PHE A 381
 FAD  A 527 (-3.9A)
None
None
None
None
 1.34A 2b9eA-1f8rA:
2.2		 2b9eA-1f8rA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum) 		PF00328
(His_Phos_2) 		5 GLY A 289
LEU A 187
ASP A 188
ASP A 335
SER A 314
 None
 1.35A 2b9eA-1ihpA:
undetectable		 2b9eA-1ihpA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjf ENDO-1,4-BETA-XYLANA
SE Z

(Ruminiclostridium
thermocellum) 		PF00756
(Esterase) 		5 CYH A 226
PRO A 267
GLY A 268
ASN A 271
ASP A 261
 None
 1.42A 2b9eA-1jjfA:
undetectable		 2b9eA-1jjfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		5 PRO A 100
GLY A 101
ASN A 102
SER A 192
PHE A 334
 None
 1.21A 2b9eA-1m1cA:
undetectable		 2b9eA-1m1cA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 GLY A 491
ASN A 492
LEU A 354
ASP A 405
SER A 498
 None
 1.46A 2b9eA-1qf7A:
undetectable		 2b9eA-1qf7A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus) 		PF00328
(His_Phos_2) 		5 GLY A 289
LEU A 187
ASP A 188
ASP A 335
SER A 314
 None
 1.31A 2b9eA-1skaA:
undetectable		 2b9eA-1skaA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t66 IMMUNOGLOBULIN HEAVY
CHAIN

(Mus musculus) 		no annotation 5 LYS H  19
LEU H   4
ASP H   5
SER H  80
PHE H  29
 None
 1.38A 2b9eA-1t66H:
undetectable		 2b9eA-1t66H:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N) 		5 GLY A  22
LEU A1220
ASP A1199
SER A  30
PHE A1195
 None
 1.45A 2b9eA-1w1wA:
undetectable		 2b9eA-1w1wA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9q 4M5.3
ANTI-FLUORESCEIN
SINGLE CHAIN
ANTIBODY FRAGMENT

(Homo sapiens) 		PF07686
(V-set) 		5 GLY A 159
LEU A 155
ASP A 156
SER A 231
PHE A 180
 None
 1.46A 2b9eA-1x9qA:
undetectable		 2b9eA-1x9qA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9q 4M5.3
ANTI-FLUORESCEIN
SINGLE CHAIN
ANTIBODY FRAGMENT

(Homo sapiens) 		PF07686
(V-set) 		5 LYS A 170
LEU A 155
ASP A 156
SER A 231
PHE A 180
 None
 1.37A 2b9eA-1x9qA:
undetectable		 2b9eA-1x9qA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi9 PUTATIVE
TRANSAMINASE

(Pyrococcus
furiosus) 		PF00155
(Aminotran_1_2) 		5 GLY A 180
ASN A 176
LEU A  35
ARG A 371
PHE A  43
 None
 1.45A 2b9eA-1xi9A:
3.2		 2b9eA-1xi9A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye9 CATALASE HPII

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 GLY E 491
ASN E 492
LEU E 354
ASP E 405
SER E 498
 None
 1.46A 2b9eA-1ye9E:
undetectable		 2b9eA-1ye9E:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo sapiens) 		PF00398
(RrnaAD) 		5 GLY A  68
ASN A  69
LEU A  86
ASP A  87
ASP A 113
 None
None
SAM  A4000 (-3.7A)
None
SAM  A4000 (-3.8A)
 1.03A 2b9eA-1zq9A:
12.2		 2b9eA-1zq9A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 PRO A 545
GLY A 551
LEU A 541
ASP A 542
PHE A 574
 None
 1.45A 2b9eA-2b5mA:
undetectable		 2b9eA-2b5mA:
13.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		12 CYH A 234
PRO A 237
GLY A 238
ASN A 239
LYS A 240
LEU A 259
ASP A 260
ARG A 263
ASP A 285
PHE A 286
SER A 307
PHE A 337
 SAM  A1201 (-3.8A)
SAM  A1201 (-3.7A)
SAM  A1201 (-3.9A)
SAM  A1201 (-4.4A)
SAM  A1201 (-3.1A)
SAM  A1201 (-4.5A)
None
SAM  A1201 (-3.9A)
SAM  A1201 (-3.6A)
None
SAM  A1201 (-3.6A)
SAM  A1201 (-4.2A)
 0.02A 2b9eA-2b9eA:
50.8		 2b9eA-2b9eA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eez ALANINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 GLY A 290
LEU A 232
ASP A 231
ARG A 154
PHE A 146
 None
 1.48A 2b9eA-2eezA:
6.6		 2b9eA-2eezA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fy2 CHOLINE
O-ACETYLTRANSFERASE

(Homo sapiens) 		PF00755
(Carn_acyltransf) 		5 CYH A 322
ASN A  95
ASP A 305
SER A 325
PHE A 327
 None
 1.16A 2b9eA-2fy2A:
2.1		 2b9eA-2fy2A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh9 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		5 GLY A 167
ASN A 260
LYS A 164
ASP A 181
PHE A 172
 None
 1.32A 2b9eA-2gh9A:
undetectable		 2b9eA-2gh9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Clostridium
acetobutylicum) 		PF02127
(Peptidase_M18) 		5 GLY A 366
ASN A 402
LEU A 438
ASP A 348
PHE A 347
 None
 1.34A 2b9eA-2gljA:
undetectable		 2b9eA-2gljA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lus THIOREDOXION

(Carcinoscorpius
rotundicauda) 		PF13905
(Thioredoxin_8) 		5 PRO A  96
GLY A  95
ASN A  99
LEU A  88
PHE A  66
 None
 1.44A 2b9eA-2lusA:
undetectable		 2b9eA-2lusA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13489
(Methyltransf_23) 		5 PRO A  41
GLY A  42
ASN A  43
ASP A  63
ASP A  83
 None
None
None
None
SAH  A 301 (-3.2A)
 0.76A 2b9eA-2p35A:
13.6		 2b9eA-2p35A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13489
(Methyltransf_23) 		5 PRO A  41
GLY A  42
ASN A  43
ASP A  63
PHE A 102
 None
 1.22A 2b9eA-2p35A:
13.6		 2b9eA-2p35A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7n PATHOGENICITY ISLAND
1 EFFECTOR PROTEIN

(Chromobacterium
violaceum) 		PF06511
(IpaD) 		5 GLY A 277
ASN A 310
LEU A 292
ASP A 316
PHE A 300
 None
 1.09A 2b9eA-2p7nA:
undetectable		 2b9eA-2p7nA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q04 ACETOIN UTILIZATION
PROTEIN

(Exiguobacterium
sibiricum) 		PF00583
(Acetyltransf_1) 		5 PRO A  23
GLY A  22
ASN A   7
LEU A  78
ARG A  61
 None
 1.38A 2b9eA-2q04A:
undetectable		 2b9eA-2q04A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5j MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
9) 		PF00500
(Late_protein_L1) 		5 CYH A 229
PRO A 232
GLY A 166
LEU A  68
ASP A 223
 None
 1.46A 2b9eA-2r5jA:
undetectable		 2b9eA-2r5jA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtx NPM-A PROTEIN

(Xenopus laevis) 		PF03066
(Nucleoplasmin) 		5 CYH A  51
PRO A 110
GLY A 109
ASN A  24
ASP A  54
 None
 1.17A 2b9eA-2vtxA:
undetectable		 2b9eA-2vtxA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3d SSO6206

(Sulfolobus
solfataricus) 		PF02680
(DUF211) 		5 GLY A  34
ASP A  30
ASP A  61
PHE A  60
SER A  57
 None
 1.27A 2b9eA-2x3dA:
undetectable		 2b9eA-2x3dA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 GLY A 222
ASN A 256
LEU A 448
ASP A 449
PHE A 502
 None
 1.36A 2b9eA-2yfnA:
undetectable		 2b9eA-2yfnA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		6 PRO A 270
GLY A 271
LYS A 273
ASP A 293
ARG A 296
ASP A 318
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
None
SFG  A5748 (-3.0A)
SFG  A5748 (-3.7A)
 0.70A 2b9eA-2yxlA:
31.1		 2b9eA-2yxlA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		5 CYH A  91
PRO A  94
GLY A  95
LYS A  97
ASP A 142
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-2.8A)
SFG  A 500 (-4.0A)
 0.31A 2b9eA-3a4tA:
28.7		 2b9eA-3a4tA:
28.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 PRO A 879
GLY A 878
ASN A 846
ASP A 940
ARG A 922
 None
 1.42A 2b9eA-3ak5A:
undetectable		 2b9eA-3ak5A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE

(Streptococcus
pneumoniae) 		PF04914
(DltD) 		5 GLY A 368
ASN A 328
LEU A 386
ASP A 389
PHE A 388
 None
 1.36A 2b9eA-3bmaA:
undetectable		 2b9eA-3bmaA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db9 UPF0317 PROTEIN
ATU3911

(Agrobacterium
fabrum) 		PF07286
(DUF1445) 		5 PRO A 254
GLY A 255
ASN A 148
ARG A  94
ASP A 107
 None
 1.40A 2b9eA-3db9A:
undetectable		 2b9eA-3db9A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebc TYPE-2 RESTRICTION
ENZYME HINCII

(Haemophilus
influenzae) 		PF09226
(Endonuc-HincII) 		5 ASN A 132
LEU A 215
ASP A 214
ARG A 213
SER A 186
 None
 1.28A 2b9eA-3ebcA:
undetectable		 2b9eA-3ebcA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		5 GLY A 253
LEU A 217
ASP A 128
ARG A 130
ASP A 229
 PO4  A   1 (-4.2A)
None
None
None
None
 1.14A 2b9eA-3f41A:
undetectable		 2b9eA-3f41A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1d 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 GLY A 111
ARG A 135
ASP A 213
PHE A 215
PHE A 217
 None
 1.34A 2b9eA-3k1dA:
undetectable		 2b9eA-3k1dA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow2 50S RIBOSOMAL
PROTEIN L24E

(Haloarcula
marismortui) 		PF01246
(Ribosomal_L24e) 		5 CYH T  32
PRO T  15
GLY T  16
ASP T  12
PHE T  31
 CD  T8701 (-2.2A)
None
None
None
None
 1.49A 2b9eA-3ow2T:
undetectable		 2b9eA-3ow2T:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyf CRISPR-ASSOCIATED
PROTEIN

(Sulfolobus
solfataricus) 		PF09651
(Cas_APE2256) 		5 GLY A 166
LEU A  37
ASP A  35
ASP A  41
PHE A  39
 None
 1.37A 2b9eA-3qyfA:
3.9		 2b9eA-3qyfA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Aquifex
aeolicus) 		PF00398
(RrnaAD) 		5 GLY B  42
ASN B  43
LEU B  61
ASP B  62
ASP B  83
 None
 1.33A 2b9eA-3r9xB:
14.7		 2b9eA-3r9xB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tma METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		5 GLY A 196
LEU A 217
ASP A 218
ARG A 221
ASP A 243
 None
 0.61A 2b9eA-3tmaA:
6.6		 2b9eA-3tmaA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT

(Homo sapiens) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		5 PRO A  24
GLY A  25
LEU A  72
ASP A  71
PHE A  81
 None
 1.41A 2b9eA-3v4yA:
undetectable		 2b9eA-3v4yA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 GLY A 390
LEU A 478
ASP A 479
ASP A 484
SER A 446
 None
 1.25A 2b9eA-4cgyA:
undetectable		 2b9eA-4cgyA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cz2 RAS-RELATED PROTEIN
RAB-32

(Homo sapiens) 		PF00071
(Ras) 		5 GLY A  84
LEU A 124
ASP A 123
ARG A  87
PHE A 167
 GCP  A1198 (-4.0A)
None
None
None
None
 1.35A 2b9eA-4cz2A:
undetectable		 2b9eA-4cz2A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezd UREA TRANSPORTER 1

(Bos taurus) 		PF03253
(UT) 		5 PRO A  70
GLY A  73
LEU A 116
ARG A  59
PHE A  66
 None
None
None
None
SEY  A 402 (-4.8A)
 1.31A 2b9eA-4ezdA:
undetectable		 2b9eA-4ezdA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		7 CYH A 181
PRO A 185
GLY A 185
LYS A 187
LEU A 205
ARG A 209
ASP A 237
 SAM  A 401 (-3.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.8A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
 0.80A 2b9eA-4fzvA:
23.2		 2b9eA-4fzvA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963

(Streptomyces
coelicolor) 		no annotation 5 ASN B 228
LEU B 185
ASP B 186
ARG B 189
ASP B 183
 None
 1.49A 2b9eA-4gt2B:
undetectable		 2b9eA-4gt2B:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isy CYSTEINE DESULFURASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		5 GLY A 157
ASN A 153
LEU A   4
ARG A 355
ASP A 366
 None
 1.16A 2b9eA-4isyA:
3.4		 2b9eA-4isyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae) 		PF00266
(Aminotran_5) 		5 GLY A 148
ASN A 144
LEU A   4
ARG A 344
ASP A 355
 None
 1.27A 2b9eA-4ixoA:
3.2		 2b9eA-4ixoA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		5 CYH A 277
PRO A 280
GLY A 281
LEU A 302
ASP A 335
 SAM  A 601 (-3.7A)
SAM  A 601 (-3.6A)
SAM  A 601 (-3.6A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
 0.91A 2b9eA-4n49A:
8.7		 2b9eA-4n49A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4r LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Salmonella
enterica;
Salmonella
enterica) 		PF04453
(OstA_C)
PF04390
(LptE) 		5 PRO A 781
LEU A 738
ASP A 716
PHE B  90
SER A 350
 None
 1.42A 2b9eA-4n4rA:
undetectable		 2b9eA-4n4rA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5x CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
SCAMC-1

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 GLY A  47
ASN A  50
ASP A  40
ASP A  76
PHE A  77
 None
None
None
CA  A 203 ( 4.9A)
None
 1.38A 2b9eA-4n5xA:
undetectable		 2b9eA-4n5xA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvi AMINOTRANSFERASE,
CLASS IV

(Brucella
abortus) 		PF01063
(Aminotran_4) 		5 PRO A  88
ASN A  78
LEU A 131
ASP A 124
SER A  54
 None
 1.46A 2b9eA-4tviA:
undetectable		 2b9eA-4tviA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 5 GLY A1700
ASN A1701
LEU A1720
ASP A1755
PHE A1782
 None
 0.97A 2b9eA-4uclA:
7.7		 2b9eA-4uclA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uys FLOCCULATION PROTEIN
FLO11

(Saccharomyces
cerevisiae) 		PF10182
(Flo11) 		5 PRO A 193
GLY A 194
ASN A  42
ASP A 191
PHE A 126
 None
 1.31A 2b9eA-4uysA:
undetectable		 2b9eA-4uysA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN

(Schizosaccharomyces
pombe) 		no annotation 5 PRO A 692
GLY A 693
ASP A 648
PHE A 717
PHE A 657
 None
 1.45A 2b9eA-4yhcA:
undetectable		 2b9eA-4yhcA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		5 GLY K 112
ASN K  21
LEU K 136
ARG K 373
PHE K 612
 None
 1.44A 2b9eA-5anbK:
2.5		 2b9eA-5anbK:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA

(Mycolicibacterium
thermoresistibile) 		no annotation 5 PRO C 197
GLY C 196
ASP C 202
PHE C 152
PHE C 157
 None
 1.47A 2b9eA-5cw2C:
undetectable		 2b9eA-5cw2C:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Homo sapiens) 		PF01652
(IF4E) 		5 PRO A  87
GLY A  88
ASN A  50
LYS A  49
LEU A  81
 None
 1.41A 2b9eA-5ei3A:
undetectable		 2b9eA-5ei3A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxe EUGENOL OXIDASE

(Rhodococcus
jostii) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 PRO A 511
GLY A 512
LEU A 503
ASP A 504
PHE A 219
 None
 1.40A 2b9eA-5fxeA:
undetectable		 2b9eA-5fxeA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5x SITE-2 PROTEASE
NANOBODY

(Archaeoglobus
fulgidus;
Lama glama) 		PF00571
(CBS)
PF07686
(V-set) 		5 PRO A 247
GLY A 293
LEU A 257
SER B  56
PHE B  54
 None
 1.47A 2b9eA-5g5xA:
undetectable		 2b9eA-5g5xA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0w CLASS B
CARBAPENEMASE GOB-18

(Elizabethkingia
meningoseptica) 		PF00753
(Lactamase_B) 		5 GLY A  42
ASN A  43
ASP A 235
ASP A 264
PHE A 245
 None
 1.44A 2b9eA-5k0wA:
undetectable		 2b9eA-5k0wA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		5 GLY A  87
ASN A  85
LEU A 422
ASP A 423
PHE A 381
 FAD  A 501 (-3.9A)
None
None
None
None
 1.31A 2b9eA-5ts5A:
2.6		 2b9eA-5ts5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL

(Aspergillus
fumigatus) 		no annotation 5 GLY A 249
LEU A 258
ASP A 257
PHE A 420
SER A 238
 None
 0.96A 2b9eA-5uqrA:
undetectable		 2b9eA-5uqrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 CYH A 242
PRO A 245
GLY A 246
LYS A 248
ASP A 293
 None
C  C  72 ( 4.7A)
None
C  C  72 ( 3.1A)
None
 0.26A 2b9eA-5wwtA:
15.4		 2b9eA-5wwtA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0k IOTA-CARRAGEENAN
SULFATASE

(Pseudoalteromonas) 		no annotation 5 PRO A  80
GLY A  79
ASN A  99
ASP A 112
SER A 453
 None
None
G4S  A 503 ( 3.4A)
None
None
 1.15A 2b9eA-6b0kA:
undetectable		 2b9eA-6b0kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bng 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Acinetobacter
baumannii) 		no annotation 5 PRO A 209
GLY A 210
ASN A 179
ASP A 252
ASP A 247
 None
 1.38A 2b9eA-6bngA:
undetectable		 2b9eA-6bngA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzc GLUCOSE-6-PHOSPHATE
ISOMERASE

(Elizabethkingia
anophelis) 		no annotation 5 PRO A 379
GLY A 380
ASN A 382
LEU A 348
ASP A 352
 None
 1.44A 2b9eA-6bzcA:
undetectable		 2b9eA-6bzcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza B
virus;
Influenza B
virus) 		no annotation
no annotation 		5 GLY A 425
ASN B 599
LEU B 588
ASP B 586
ASP B 592
 None
 1.30A 2b9eA-6f5oA:
undetectable		 2b9eA-6f5oA:
undetectable