SIMILAR PATTERNS OF AMINO ACIDS FOR 2B8J_B_ADNB331_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewr DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 SER A 274
PHE A 273
LEU A 292
GLY A 284
ARG A 285
 None
 1.06A 2b8jB-1ewrA:
0.0		 2b8jB-1ewrA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 SER A  45
PHE A  42
TYR A  38
GLY A  22
TYR A 158
 None
 1.43A 2b8jB-1kfiA:
1.3		 2b8jB-1kfiA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkf LEUKOCIDIN F SUBUNIT

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		5 ASP A  26
TYR A 278
LEU A  36
GLY A  57
THR A 292
 None
 1.39A 2b8jB-1lkfA:
undetectable		 2b8jB-1lkfA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 SER A 548
PHE A 547
GLY A 585
THR A 580
TYR A 582
 None
 1.33A 2b8jB-1s4fA:
0.0		 2b8jB-1s4fA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqh HYPOTHETICAL PROTEIN
CG14615-PA

(Drosophila
melanogaster) 		PF08445
(FR47) 		5 SER A  94
PHE A  95
LEU A 106
TRP A 107
GLY A 130
 None
 1.17A 2b8jB-1sqhA:
undetectable		 2b8jB-1sqhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txk GLUCANS BIOSYNTHESIS
PROTEIN G

(Escherichia
coli) 		PF04349
(MdoG) 		5 PHE A 310
LEU A 250
GLY A 246
THR A 338
TYR A 383
 None
 1.21A 2b8jB-1txkA:
undetectable		 2b8jB-1txkA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE

(Pseudomonas
putida;
Spinacia
oleracea) 		PF01070
(FMN_dh) 		5 PHE A 212
LEU A 220
TRP A 219
ARG A 135
THR A 157
 None
 1.50A 2b8jB-2a7nA:
0.0		 2b8jB-2a7nA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 SER A 548
PHE A 547
GLY A 585
THR A 580
TYR A 582
 None
 1.31A 2b8jB-2cjqA:
undetectable		 2b8jB-2cjqA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1m L-GLUTAMATE OXIDASE

(Streptomyces
sp. X-119-6) 		PF01593
(Amino_oxidase) 		5 SER B 443
PHE B 442
LEU C 584
GLY C 592
THR C 600
 None
 1.40A 2b8jB-2e1mB:
undetectable		 2b8jB-2e1mB:
23.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hf7 CLASS B ACID
PHOSPHATASE

(Escherichia
coli) 		PF03767
(Acid_phosphat_B) 		10 ASP A  46
SER A  53
PHE A  56
TYR A  70
LEU A  71
TRP A  77
GLY A 113
ARG A 114
THR A 192
TYR A 193
 AF3  A 800 ( 3.7A)
None
None
None
None
None
AF3  A 800 (-3.5A)
None
None
None
 0.23A 2b8jB-2hf7A:
34.4		 2b8jB-2hf7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsd MATRIX
METALLOPROTEINASE-20

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 PHE A 218
TYR A 248
GLY A 184
ARG A 186
THR A 212
 None
NGH  A 277 (-4.4A)
CA  A 273 (-4.5A)
None
None
 1.43A 2b8jB-2jsdA:
undetectable		 2b8jB-2jsdA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsd MATRIX
METALLOPROTEINASE-20

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 TYR A 248
LEU A 189
GLY A 184
ARG A 186
THR A 212
 NGH  A 277 (-4.4A)
NGH  A 277 (-4.1A)
CA  A 273 (-4.5A)
None
None
 1.25A 2b8jB-2jsdA:
undetectable		 2b8jB-2jsdA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8e UPF0339 PROTEIN YEGP

(Escherichia
coli) 		PF07411
(DUF1508) 		5 SER A  51
PHE A  31
LEU A  23
GLY A 127
THR A  53
 None
 1.45A 2b8jB-2k8eA:
undetectable		 2b8jB-2k8eA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF09110
(HAND)
PF09111
(SLIDE)
PF15612
(WHIM1) 		5 ASP A 997
SER A 993
GLY A1046
ARG A1045
THR B 426
 None
 1.32A 2b8jB-2y9yA:
undetectable		 2b8jB-2y9yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS

(Escherichia
coli) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 ASP A 296
SER A 293
GLY A 303
ARG A 128
THR A 290
 None
 1.48A 2b8jB-3k0sA:
undetectable		 2b8jB-3k0sA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljf IRON SUPEROXIDE
DISMUTASE

(Pseudoalteromonas
haloplanktis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 SER A  79
TYR A   9
LEU A  14
GLY A 177
TYR A  76
 None
 1.20A 2b8jB-3ljfA:
undetectable		 2b8jB-3ljfA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		5 SER A 322
TYR A 244
LEU A  70
GLY A  41
THR A 324
 None
 1.43A 2b8jB-3mwtA:
undetectable		 2b8jB-3mwtA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpx LIPASE

(Ustilago maydis) 		PF03583
(LIP) 		5 SER A  89
PHE A  88
TYR A 385
LEU A 381
TRP A 129
 None
 1.35A 2b8jB-3zpxA:
2.1		 2b8jB-3zpxA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cab CATALASE

(Deinococcus
radiodurans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 SER A 357
PHE A 356
LEU A 350
GLY A 346
TYR A 231
 None
 1.33A 2b8jB-4cabA:
undetectable		 2b8jB-4cabA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 ASP A  81
GLY A  21
ARG A 216
THR A  93
TYR A  78
 None
ATP  A 502 (-3.3A)
None
None
None
 1.46A 2b8jB-4gniA:
undetectable		 2b8jB-4gniA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh1 APPA PROTEIN

(Rhodobacter
sphaeroides) 		PF04940
(BLUF) 		5 SER A 142
PHE A 141
LEU A 227
GLY A 187
THR A 220
 None
 1.37A 2b8jB-4hh1A:
3.1		 2b8jB-4hh1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip3 ORF169B

(Shigella
flexneri) 		no annotation 5 SER A 193
PHE A 197
TYR A  76
LEU A  74
GLY A 149
 None
 1.35A 2b8jB-4ip3A:
undetectable		 2b8jB-4ip3A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0a E3 UBIQUITIN-PROTEIN
LIGASE RNF31

(Homo sapiens) 		PF09409
(PUB) 		5 ASP A 110
PHE A 105
TYR A  82
GLY A 114
ARG A 116
 None
 0.92A 2b8jB-4p0aA:
undetectable		 2b8jB-4p0aA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 ASP A 555
PHE A 551
GLY A 561
ARG A  58
THR A 550
 None
 1.30A 2b8jB-4tweA:
undetectable		 2b8jB-4tweA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfq SUPPRESSOR OF
STEM-LOOP PROTEIN 1

(Saccharomyces
cerevisiae) 		PF04056
(Ssl1) 		5 ASP A 284
PHE A 287
LEU A 308
THR A 280
TYR A 282
 None
 1.24A 2b8jB-4wfqA:
2.5		 2b8jB-4wfqA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2u NANOBODY

(Camelus
dromedarius) 		PF07686
(V-set) 		5 PHE B  64
LEU B  77
GLY B  43
ARG B  34
TYR B  56
 None
 1.37A 2b8jB-5c2uB:
undetectable		 2b8jB-5c2uB:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldt MOMP PORIN

(Campylobacter
jejuni) 		PF05538
(Campylo_MOMP) 		6 PHE A 303
TYR A 276
LEU A 310
GLY A 294
THR A 305
TYR A 304
 None
 1.39A 2b8jB-5ldtA:
undetectable		 2b8jB-5ldtA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lo7 FIMBRIAL PROTEIN
MYFA,FIMBRIAL
PROTEIN MYFA

(Yersinia
enterocolitica) 		no annotation 5 SER A 137
PHE A 113
LEU A  73
TRP A  85
GLY A  60
 None
 1.04A 2b8jB-5lo7A:
undetectable		 2b8jB-5lo7A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE

(Leishmania
major) 		no annotation 5 ASP A 108
PHE A 142
LEU A 143
ARG A 146
THR A  96
 None
 1.27A 2b8jB-5nzgA:
1.6		 2b8jB-5nzgA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5

(Homo sapiens) 		no annotation 5 SER A 211
PHE A 212
TYR A  57
LEU A  59
GLY A 177
 NAG  A 502 (-3.9A)
None
None
None
None
 1.19A 2b8jB-5o8fA:
undetectable		 2b8jB-5o8fA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3j DH511.1 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PHE H  91
LEU H  45
GLY H  88
ARG H  89
THR H  93
 None
 1.44A 2b8jB-5u3jH:
undetectable		 2b8jB-5u3jH:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 5 SER A 548
PHE A 547
GLY A 585
THR A 580
TYR A 582
 SO4  A 713 (-4.8A)
None
None
SO4  A 713 (-3.3A)
None
 1.33A 2b8jB-5y6rA:
undetectable		 2b8jB-5y6rA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1 -

(-) 		no annotation 5 SER E 211
PHE E 212
TYR E  57
LEU E  59
GLY E 177
 NAG  E 501 (-2.3A)
None
None
None
None
 1.27A 2b8jB-6dw1E:
undetectable		 2b8jB-6dw1E:
undetectable