SIMILAR PATTERNS OF AMINO ACIDS FOR 2B25_B_SAMB602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7v CALCIUM VECTOR
PROTEIN

(Branchiostoma
lanceolatum) 		PF13499
(EF-hand_7) 		3 GLY A 101
GLU A 109
ASP A 102
 None
 0.64A 2b25B-1c7vA:
undetectable		 2b25B-1c7vA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbn MJ FIBRILLARIN
HOMOLOGUE

(Methanocaldococcus
jannaschii) 		PF01269
(Fibrillarin) 		3 GLY A  82
GLU A 105
ASP A 150
 None
 0.70A 2b25B-1fbnA:
14.1		 2b25B-1fbnA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 GLY A 393
GLU A 391
ASP A 394
 None
 0.58A 2b25B-1hplA:
undetectable		 2b25B-1hplA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		3 GLY A 107
GLU A 131
ASP A 178
 SAM  A 301 (-2.7A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.4A)
 0.20A 2b25B-1i9gA:
27.3		 2b25B-1i9gA:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		3 GLY A 138
GLU A 136
ASP A 139
 None
 0.68A 2b25B-1ikpA:
undetectable		 2b25B-1ikpA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLY A  98
GLU A 121
ASP A 170
 None
 0.62A 2b25B-1inlA:
10.5		 2b25B-1inlA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3v CAPSID PROTEIN VP2

(Ungulate
protoparvovirus
1) 		PF00740
(Parvo_coat) 		3 GLY A 300
GLU A 299
ASP A 301
 None
 0.70A 2b25B-1k3vA:
undetectable		 2b25B-1k3vA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khh GUANIDINOACETATE
METHYLTRANSFERASE

(Rattus
norvegicus) 		no annotation 3 GLY A  67
GLU A  89
ASP A 134
 SAH  A 236 (-3.3A)
SAH  A 236 (-2.8A)
SAH  A 236 (-3.4A)
 0.39A 2b25B-1khhA:
12.3		 2b25B-1khhA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLY A  82
GLU A 104
ASP A 158
 None
 0.68A 2b25B-1mjfA:
10.5		 2b25B-1mjfA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN

(Archaeoglobus
fulgidus) 		PF01269
(Fibrillarin) 		3 GLY A  65
GLU A  88
ASP A 133
 SAM  A 301 ( 3.8A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.7A)
 0.32A 2b25B-1nt2A:
13.7		 2b25B-1nt2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		3 GLY A 108
GLU A 132
ASP A 176
 None
 0.39A 2b25B-1o54A:
25.6		 2b25B-1o54A:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzq EQUINATOXIN II

(Actinia equina) 		PF06369
(Anemone_cytotox) 		3 GLY A  11
GLU A  40
ASP A  10
 None
 0.67A 2b25B-1tzqA:
undetectable		 2b25B-1tzqA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 GLY A  19
GLU A 220
ASP A 256
 None
 0.70A 2b25B-1wl4A:
undetectable		 2b25B-1wl4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE

(Rattus
norvegicus) 		no annotation 3 GLY A  67
GLU A  89
ASP A 134
 SAH  A 236 (-3.4A)
SAH  A 236 (-2.9A)
NMG  A 237 ( 3.0A)
 0.36A 2b25B-1xcjA:
12.5		 2b25B-1xcjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhl SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY MEMBER
(5L265), PUTATIVE
TROPINONE
REDUCTASE-II

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		3 GLY A  72
GLU A  69
ASP A  75
 None
 0.68A 2b25B-1xhlA:
6.1		 2b25B-1xhlA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME

(Thermotoga
maritima) 		PF10396
(TrmE_N) 		3 GLY B  23
GLU B  74
ASP B  25
 None
 0.69A 2b25B-1xzqB:
undetectable		 2b25B-1xzqB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb2 HYPOTHETICAL PROTEIN
TA0852

(Thermoplasma
acidophilum) 		PF08704
(GCD14) 		3 GLY A  98
GLU A 122
ASP A 166
 None
 0.46A 2b25B-1yb2A:
15.9		 2b25B-1yb2A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avd CATECHOL-O-METHYLTRA
NSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		3 GLY A 110
GLU A 134
ASP A 185
 SAM  A 501 (-3.4A)
SAM  A 501 (-2.9A)
SAM  A 501 (-3.4A)
 0.19A 2b25B-2avdA:
15.0		 2b25B-2avdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLY A 209
GLU A 111
ASP A 189
 None
 0.42A 2b25B-2b1pA:
undetectable		 2b25B-2b1pA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		3 GLY A 111
GLU A 135
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-2.9A)
SAM  A 601 (-3.5A)
 0.12A 2b25B-2b25A:
37.0		 2b25B-2b25A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9l PROPHENOLOXIDASE
ACTIVATING FACTOR

(Holotrichia
diomphalia) 		PF00089
(Trypsin) 		3 GLY A  59
GLU A 104
ASP A  63
 None
 0.61A 2b25B-2b9lA:
undetectable		 2b25B-2b9lA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		3 GLY A 125
GLU A 181
ASP A 122
 None
None
MN  A 302 (-2.5A)
 0.65A 2b25B-2cevA:
undetectable		 2b25B-2cevA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90) 		3 GLY A 559
GLU A 556
ASP A 560
 None
 0.69A 2b25B-2cgeA:
undetectable		 2b25B-2cgeA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzm FAS-ASSOCIATED
FACTOR 1

(Homo sapiens) 		no annotation 3 GLY A  32
GLU A  33
ASP A  61
 None
 0.62A 2b25B-2dzmA:
undetectable		 2b25B-2dzmA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6s E3 UBIQUITIN-PROTEIN
LIGASE UHRF2

(Homo sapiens) 		PF00628
(PHD) 		3 GLY A  18
GLU A  12
ASP A  19
 None
 0.69A 2b25B-2e6sA:
undetectable		 2b25B-2e6sA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7u TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		3 GLY A 110
GLU A 161
ASP A 109
 None
 0.58A 2b25B-2g7uA:
undetectable		 2b25B-2g7uA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 GLY A  53
GLU A 254
ASP A 288
 None
 0.63A 2b25B-2ibuA:
undetectable		 2b25B-2ibuA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN

(Homo sapiens) 		PF01269
(Fibrillarin) 		3 GLY A 168
GLU A 192
ASP A 237
 MTA  A4001 (-3.3A)
MTA  A4001 (-2.7A)
MTA  A4001 (-4.3A)
 0.29A 2b25B-2ipxA:
14.6		 2b25B-2ipxA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mw1 LIPOCALIN-LIKE
PROTEIN

(Bacteroides
thetaiotaomicron) 		no annotation 3 GLY A  69
GLU A  54
ASP A  68
 None
 0.64A 2b25B-2mw1A:
undetectable		 2b25B-2mw1A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n4i SELECTION AND UPKEEP
OF INTRAEPITHELIAL
T-CELLS PROTEIN 1

(Mus musculus) 		PF07686
(V-set) 		3 GLY A 128
GLU A  61
ASP A 129
 None
 0.61A 2b25B-2n4iA:
undetectable		 2b25B-2n4iA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyp BETA-LACTAMASE II

(Bacillus cereus) 		PF00753
(Lactamase_B) 		3 GLY A 214
GLU A 212
ASP A 215
 None
 0.70A 2b25B-2nypA:
undetectable		 2b25B-2nypA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oo4 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2

(Homo sapiens) 		PF00066
(Notch)
PF06816
(NOD)
PF07684
(NODP) 		3 GLY A1453
GLU A1460
ASP A1454
 None
None
CA  A5001 (-3.4A)
 0.68A 2b25B-2oo4A:
undetectable		 2b25B-2oo4A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7n PATHOGENICITY ISLAND
1 EFFECTOR PROTEIN

(Chromobacterium
violaceum) 		PF06511
(IpaD) 		3 GLY A 198
GLU A 201
ASP A 194
 None
 0.55A 2b25B-2p7nA:
undetectable		 2b25B-2p7nA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLY A 124
GLU A 147
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-2.6A)
 0.63A 2b25B-2pt6A:
9.7		 2b25B-2pt6A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		3 GLY A 233
GLU A 258
ASP A 341
 UNL  A 414 (-4.0A)
None
None
 0.37A 2b25B-2py6A:
9.6		 2b25B-2py6A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 3 GLY A   2
GLU A  11
ASP A 336
 None
 0.44A 2b25B-2quaA:
undetectable		 2b25B-2quaA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		3 GLY A  86
GLU A 121
ASP A 198
 None
 0.34A 2b25B-2qy6A:
10.0		 2b25B-2qy6A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmo LMO2642 PROTEIN

(Listeria
monocytogenes) 		PF00149
(Metallophos) 		3 GLY A 106
GLU A 107
ASP A 136
 None
 0.68A 2b25B-2xmoA:
undetectable		 2b25B-2xmoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		3 GLY A 248
GLU A 379
ASP A 249
 None
 0.59A 2b25B-2yg1A:
undetectable		 2b25B-2yg1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		3 GLY A  99
GLU A 120
ASP A 165
 SAM  A 601 (-3.2A)
SAM  A 601 (-2.7A)
SAM  A 601 (-3.4A)
 0.38A 2b25B-2yvlA:
26.6		 2b25B-2yvlA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbc 83AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR ASNC

(Sulfurisphaera
tokodaii) 		PF01037
(AsnC_trans_reg) 		3 GLY A  14
GLU A  17
ASP A  11
 None
 0.68A 2b25B-2zbcA:
undetectable		 2b25B-2zbcA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLY A  84
GLU A 107
ASP A 161
 None
None
AG3  A1001 (-2.8A)
 0.59A 2b25B-2zsuA:
10.5		 2b25B-2zsuA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5q PUTATIVE SULFATASE
YIDJ

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 GLY A 116
GLU A 131
ASP A 175
 None
 0.70A 2b25B-3b5qA:
undetectable		 2b25B-3b5qA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwm CATECHOL
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		3 GLY A  66
GLU A  90
ASP A 141
 SAM  A 301 (-3.2A)
SAM  A 301 (-2.8A)
MG  A 300 (-2.4A)
 0.25A 2b25B-3bwmA:
15.3		 2b25B-3bwmA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLY A 198
GLU A 220
ASP A 276
 MTA  A 401 (-3.3A)
MTA  A 401 (-2.5A)
SPM  A 501 ( 3.2A)
 0.64A 2b25B-3c6mA:
11.6		 2b25B-3c6mA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3caw O-SUCCINYLBENZOATE
SYNTHASE

(Bdellovibrio
bacteriovorus) 		no annotation 3 GLY A 275
GLU A  97
ASP A 276
 None
 0.65A 2b25B-3cawA:
undetectable		 2b25B-3cawA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION

(Ruegeria
pomeroyi) 		no annotation 3 GLY A  37
GLU A  57
ASP A 128
 None
 0.25A 2b25B-3cvoA:
10.6		 2b25B-3cvoA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dho STREPTOGRAMIN A
ACETYLTRANSFERASE

(Enterococcus
faecium) 		PF00132
(Hexapep) 		3 GLY A  72
GLU A  44
ASP A 125
 None
 0.70A 2b25B-3dhoA:
undetectable		 2b25B-3dhoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dv9 BETA-PHOSPHOGLUCOMUT
ASE

(Bacteroides
vulgatus) 		PF13419
(HAD_2) 		3 GLY A  29
GLU A  62
ASP A  33
 MG  A 301 ( 4.6A)
MG  A 301 ( 3.1A)
None
 0.68A 2b25B-3dv9A:
2.3		 2b25B-3dv9A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdi UNCHARACTERIZED
PROTEIN

(Eubacterium
ventriosum) 		PF13189
(Cytidylate_kin2) 		3 GLY A 122
GLU A  11
ASP A 123
 None
 0.65A 2b25B-3fdiA:
undetectable		 2b25B-3fdiA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN

(Bacteroides
thetaiotaomicron) 		PF10282
(Lactonase) 		3 GLY A 284
GLU A 252
ASP A 285
 None
 0.70A 2b25B-3fgbA:
undetectable		 2b25B-3fgbA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum) 		no annotation 3 GLY A  94
GLU A 117
ASP A 163
 None
FMT  A 315 (-3.6A)
None
 0.35A 2b25B-3gjyA:
11.0		 2b25B-3gjyA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goa 3-KETOACYL-COA
THIOLASE

(Salmonella
enterica) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 GLY A  15
GLU A 208
ASP A 243
 None
 0.59A 2b25B-3goaA:
undetectable		 2b25B-3goaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE

(Ruegeria
pomeroyi) 		PF12692
(Methyltransf_17) 		3 GLY A  47
GLU A  70
ASP A 112
 SAM  A 200 (-3.3A)
SAM  A 200 (-2.7A)
SAM  A 200 (-3.7A)
 0.58A 2b25B-3ihtA:
9.8		 2b25B-3ihtA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipw HYDROLASE TATD
FAMILY PROTEIN

(Entamoeba
histolytica) 		PF01026
(TatD_DNase) 		3 GLY A 180
GLU A 184
ASP A 179
 None
 0.65A 2b25B-3ipwA:
undetectable		 2b25B-3ipwA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		3 GLY A 101
GLU A 125
ASP A 169
 SAH  A 301 (-3.1A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.6A)
 0.39A 2b25B-3lgaA:
25.2		 2b25B-3lgaA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lim FRAGACEATOXIN C

(Actinia
fragacea) 		PF06369
(Anemone_cytotox) 		3 GLY A  11
GLU A  40
ASP A  10
 None
 0.62A 2b25B-3limA:
undetectable		 2b25B-3limA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE

(Ehrlichia
chaffeensis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 GLY A 350
GLU A 352
ASP A 406
 None
 0.56A 2b25B-3lp8A:
2.8		 2b25B-3lp8A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m65 ATP-DEPENDENT
PROTEASE LA 1

(Bacillus
subtilis) 		PF02190
(LON_substr_bdg) 		3 GLY A  62
GLU A 103
ASP A  64
 None
 0.57A 2b25B-3m65A:
undetectable		 2b25B-3m65A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca PROTEIN DOM34

(Schizosaccharomyces
pombe) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		3 GLY B 353
GLU B 274
ASP B 357
 None
 0.65A 2b25B-3mcaB:
undetectable		 2b25B-3mcaB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on2 PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13305
(WHG) 		3 GLY A  29
GLU A 106
ASP A  31
 None
 0.59A 2b25B-3on2A:
undetectable		 2b25B-3on2A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orh GUANIDINOACETATE
N-METHYLTRANSFERASE

(Homo sapiens) 		no annotation 3 GLY A  68
GLU A  90
ASP A 135
 SAH  A4000 (-3.4A)
SAH  A4000 (-2.7A)
SAH  A4000 (-3.7A)
 0.39A 2b25B-3orhA:
12.0		 2b25B-3orhA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pge SUMO-MODIFIED
PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF02747
(PCNA_C)
PF11976
(Rad60-SLD) 		3 GLY A  69
GLU A 101
ASP A  68
 None
 0.67A 2b25B-3pgeA:
undetectable		 2b25B-3pgeA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		3 GLY A  66
GLU A 101
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 (-2.6A)
SAM  A 670 (-3.4A)
 0.32A 2b25B-3ps9A:
9.6		 2b25B-3ps9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		3 GLY A  66
GLU A 101
ASP A 178
 None
 0.37A 2b25B-3pvcA:
10.0		 2b25B-3pvcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		3 GLY A1313
GLU A1349
ASP A1317
 None
 0.65A 2b25B-3pvlA:
undetectable		 2b25B-3pvlA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLY A 101
GLU A 124
ASP A 173
 DSH  A 303 (-3.4A)
DSH  A 303 (-2.6A)
DSH  A 303 (-3.0A)
 0.61A 2b25B-3rw9A:
9.7		 2b25B-3rw9A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfw PUTATIVE
O-METHYLTRANSFERASE

(Klebsiella
pneumoniae) 		PF01596
(Methyltransf_3) 		3 GLY A  69
GLU A  93
ASP A 141
 None
 0.26A 2b25B-3tfwA:
15.3		 2b25B-3tfwA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 GLY A 567
GLU A 570
ASP A 566
 None
 0.64A 2b25B-3ulzA:
undetectable		 2b25B-3ulzA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpj TSE1-SPECIFIC
IMMUNITY PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 3 GLY E  84
GLU E 105
ASP E  83
 None
 0.69A 2b25B-3vpjE:
undetectable		 2b25B-3vpjE:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		3 GLY A 104
GLU A 133
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.8A)
 0.30A 2b25B-3vywA:
9.7		 2b25B-3vywA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arp PESTICIN

(Yersinia pestis) 		PF16754
(Pesticin) 		3 GLY A 104
GLU A  66
ASP A 103
 None
 0.41A 2b25B-4arpA:
undetectable		 2b25B-4arpA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Pyrococcus
furiosus) 		PF01269
(Fibrillarin) 		3 GLY E  81
GLU E 105
ASP E 150
 None
None
C  X   5 ( 3.2A)
 0.59A 2b25B-4by9E:
12.0		 2b25B-4by9E:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 GLY A  18
GLU A 221
ASP A 255
 None
 0.69A 2b25B-4c2kA:
undetectable		 2b25B-4c2kA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 GLY A  20
GLU A 222
ASP A 256
 None
 0.69A 2b25B-4dd5A:
undetectable		 2b25B-4dd5A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		3 GLY A  85
GLU A 109
ASP A 154
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.6A)
 0.26A 2b25B-4df3A:
14.1		 2b25B-4df3A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Campylobacter
jejuni) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		3 GLY A 375
GLU A 373
ASP A 377
 None
 0.65A 2b25B-4ehiA:
2.1		 2b25B-4ehiA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emy AMINOTRANSFERASE
CLASS I AND II

(Anaerococcus
prevotii) 		PF00155
(Aminotran_1_2) 		3 GLY A 231
GLU A 226
ASP A 232
 None
 0.57A 2b25B-4emyA:
2.3		 2b25B-4emyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcx ISOCITRATE
DEHYDROGENASE [NADP]

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		3 GLY A  48
GLU A  50
ASP A  17
 None
 0.61A 2b25B-4hcxA:
undetectable		 2b25B-4hcxA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 GLY A 966
GLU A 852
ASP A 967
 None
 0.70A 2b25B-4lglA:
2.5		 2b25B-4lglA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmh HEPARINASE III
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		3 GLY A 641
GLU A 661
ASP A 637
 None
 0.56A 2b25B-4mmhA:
undetectable		 2b25B-4mmhA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo2 UDP-GALACTOPYRANOSE
MUTASE

(Campylobacter
jejuni) 		no annotation 3 GLY B 149
GLU B 152
ASP B 270
 None
 0.63A 2b25B-4mo2B:
2.8		 2b25B-4mo2B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		3 GLY A 109
GLU A 133
ASP A 184
 2F6  A 301 (-3.6A)
2F6  A 301 (-2.7A)
None
 0.19A 2b25B-4p58A:
15.5		 2b25B-4p58A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN

(Anaplasma
phagocytophilum) 		PF01596
(Methyltransf_3) 		3 GLY A  64
GLU A  88
ASP A 136
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.6A)
MN  A 303 ( 2.7A)
 0.15A 2b25B-4pclA:
15.0		 2b25B-4pclA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLY A 124
GLU A 147
ASP A 196
 MTA  A 401 (-3.5A)
MTA  A 401 (-2.7A)
4ZY  A 501 ( 3.6A)
 0.67A 2b25B-4uoeA:
9.6		 2b25B-4uoeA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w78 HYDRATASE CHSH1

(Mycobacterium
tuberculosis) 		PF13452
(MaoC_dehydrat_N) 		3 GLY A 128
GLU A 126
ASP A 129
 None
 0.57A 2b25B-4w78A:
undetectable		 2b25B-4w78A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymg PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE

(Podospora
anserina) 		PF01596
(Methyltransf_3) 		3 GLY A  73
GLU A  98
ASP A 144
 SAM  A1001 (-3.3A)
SAM  A1001 (-2.7A)
SAM  A1001 (-3.6A)
 0.22A 2b25B-4ymgA:
14.3		 2b25B-4ymgA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		3 GLY A 169
GLU A  71
ASP A 149
 None
MG  A 403 (-3.4A)
None
 0.44A 2b25B-5awmA:
undetectable		 2b25B-5awmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 GLY A  17
GLU A 223
ASP A 260
 None
 0.67A 2b25B-5bz4A:
undetectable		 2b25B-5bz4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		3 GLY A 111
GLU A 135
ASP A 181
 SAH  A 301 (-3.2A)
SAH  A 301 (-2.2A)
SAH  A 301 (-2.4A)
 0.33A 2b25B-5ccxA:
24.2		 2b25B-5ccxA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		3 GLY B 118
GLU B 139
ASP B 203
 SAM  B 401 (-3.4A)
SAM  B 401 (-2.9A)
SAM  B 401 (-3.3A)
 0.35A 2b25B-5ergB:
20.6		 2b25B-5ergB:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01269
(Fibrillarin) 		3 GLY E  84
GLU E 108
ASP E 153
 SAH  E 301 (-3.8A)
SAH  E 301 (-3.0A)
SAH  E 301 (-3.7A)
 0.42A 2b25B-5ginE:
14.5		 2b25B-5ginE:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxd AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Dinoroseobacter
shibae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 GLY A 534
GLU A 366
ASP A 530
 None
 0.67A 2b25B-5gxdA:
undetectable		 2b25B-5gxdA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 3 GLY A 284
GLU A 392
ASP A 266
 None
None
CA  A 614 (-3.0A)
 0.68A 2b25B-5k8gA:
undetectable		 2b25B-5k8gA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE

(Arabidopsis
thaliana) 		PF03254
(XG_FTase) 		3 GLY A 312
GLU A 283
ASP A 315
 None
 0.60A 2b25B-5kx6A:
undetectable		 2b25B-5kx6A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		3 GLY A1157
GLU A1012
ASP A1158
 None
 0.68A 2b25B-5lsuA:
undetectable		 2b25B-5lsuA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		3 GLY A 945
GLU A1001
ASP A 944
 None
 0.63A 2b25B-5mqsA:
undetectable		 2b25B-5mqsA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5d METHYLTRANSFERASE

(Streptomyces
regensis) 		PF01596
(Methyltransf_3) 		3 GLY A  65
GLU A  89
ASP A 139
 SAM  A 306 (-3.2A)
SAM  A 306 (-2.4A)
SAM  A 306 (-2.3A)
 0.12A 2b25B-5n5dA:
15.6		 2b25B-5n5dA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		3 GLY A  39
GLU A  37
ASP A  40
 None
 0.69A 2b25B-5tzbA:
undetectable		 2b25B-5tzbA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfk UNCHARACTERIZED
PROTEIN

(Sulfolobus
solfataricus) 		no annotation 3 GLY A   9
GLU A   7
ASP A  12
 None
 0.63A 2b25B-5vfkA:
undetectable		 2b25B-5vfkA:
undetectable