SIMILAR PATTERNS OF AMINO ACIDS FOR 2B25_B_SAMB602_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a6d | THERMOSOME (ALPHASUBUNIT) (Thermoplasmaacidophilum) |
PF00118(Cpn60_TCP1) | 5 | THR A 150THR A 398SER A 145GLY A 402ILE A 472 | None | 1.07A | 2b25B-1a6dA:undetectable | 2b25B-1a6dA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aun | PR-5D (Nicotianatabacum) |
PF00314(Thaumatin) | 5 | THR A 64GLY A 104GLY A 143ASP A 98ILE A 99 | None | 1.16A | 2b25B-1aunA:undetectable | 2b25B-1aunA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cg4 | PROTEIN(ADENYLOSUCCINATESYNTHETASE) (Escherichiacoli) |
PF00709(Adenylsucc_synt) | 5 | GLY A 251SER A 252GLY A 69ASP A 231ILE A 230 | None | 1.10A | 2b25B-1cg4A:undetectable | 2b25B-1cg4A:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dgj | ALDEHYDEOXIDOREDUCTASE (Desulfovibriodesulfuricans) |
PF00111(Fer2)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2) | 5 | GLY A 866GLY A 625VAL A 804ASP A 805ILE A 808 | MCN A 914 (-3.6A)NoneMCN A 914 (-4.6A)NoneNone | 1.05A | 2b25B-1dgjA:undetectable | 2b25B-1dgjA:17.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dix | EXTRACELLULARRIBONUCLEASE LE (Solanumlycopersicum) |
PF00445(Ribonuclease_T2) | 5 | THR A 29GLY A 84ASP A 67ILE A 65MET A 72 | None | 1.09A | 2b25B-1dixA:undetectable | 2b25B-1dixA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g55 | DNA CYTOSINEMETHYLTRANSFERASEDNMT2 (Homo sapiens) |
PF00145(DNA_methylase) | 5 | GLY A 12GLY A 15MET A 16VAL A 35ILE A 57 | SAH A 392 (-3.4A)SAH A 392 (-3.1A)NoneSAH A 392 (-3.9A)SAH A 392 (-4.1A) | 0.71A | 2b25B-1g55A:7.7 | 2b25B-1g55A:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h81 | POLYAMINE OXIDASE (Zea mays) |
PF01593(Amino_oxidase) | 5 | THR A 432GLY A 429GLY A 442VAL A 10ILE A 33 | NoneFAD A 579 (-3.1A)NoneFAD A 579 (-4.6A)None | 1.17A | 2b25B-1h81A:undetectable | 2b25B-1h81A:22.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1i9g | HYPOTHETICAL PROTEINRV2118C (Mycobacteriumtuberculosis) |
PF08704(GCD14)PF14801(GCD14_N) | 6 | GLY A 109SER A 110ARG A 133HIS A 136ASP A 161MET A 179 | SAM A 301 (-3.4A)SAM A 301 (-4.4A)NoneSAM A 301 (-3.7A)SAM A 301 (-3.4A)SAM A 301 (-3.7A) | 0.58A | 2b25B-1i9gA:27.3 | 2b25B-1i9gA:31.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1i9g | HYPOTHETICAL PROTEINRV2118C (Mycobacteriumtuberculosis) |
PF08704(GCD14)PF14801(GCD14_N) | 6 | GLY A 109SER A 110GLY A 111ARG A 133HIS A 136MET A 179 | SAM A 301 (-3.4A)SAM A 301 (-4.4A)SAM A 301 (-4.2A)NoneSAM A 301 (-3.7A)SAM A 301 (-3.7A) | 1.04A | 2b25B-1i9gA:27.3 | 2b25B-1i9gA:31.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j2q | PROTEASOME BETASUBUNIT (Archaeoglobusfulgidus) |
PF00227(Proteasome) | 5 | THR H 1GLY H 128SER H 129VAL H 97ILE H 113 | CIB H1001 (-1.9A)NoneCIB H1001 ( 4.8A)NoneNone | 1.15A | 2b25B-1j2qH:undetectable | 2b25B-1j2qH:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l8t | AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE (Enterococcusfaecalis) |
PF01636(APH) | 5 | THR A 54GLY A 189SER A 212HIS A 188ILE A 258 | None | 1.16A | 2b25B-1l8tA:undetectable | 2b25B-1l8tA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1leo | NUCLEOSIDEDIPHOSPHATE KINASE (Dictyosteliumdiscoideum) |
PF00334(NDK) | 5 | THR A 11GLY A 123SER A 124VAL A 15ILE A 120 | None | 0.96A | 2b25B-1leoA:undetectable | 2b25B-1leoA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lwd | ISOCITRATEDEHYDROGENASE (Sus scrofa) |
PF00180(Iso_dh) | 5 | GLY A 263SER A 262GLY A 124VAL A 266ILE A 131 | None | 1.03A | 2b25B-1lwdA:undetectable | 2b25B-1lwdA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ndl | NUCLEOSIDEDIPHOSPHATE KINASE (Drosophilamelanogaster) |
PF00334(NDK) | 5 | THR A 8GLY A 120SER A 121VAL A 12ILE A 117 | None | 0.94A | 2b25B-1ndlA:undetectable | 2b25B-1ndlA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o2d | ALCOHOLDEHYDROGENASE,IRON-CONTAINING (Thermotogamaritima) |
PF00465(Fe-ADH) | 5 | THR A 145GLY A 141SER A 142GLY A 96ILE A 218 | NAP A1800 (-3.2A)NoneNAP A1800 (-3.3A)NAP A1800 (-3.3A)None | 1.15A | 2b25B-1o2dA:undetectable | 2b25B-1o2dA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pem | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2ALPHA CHAIN (Salmonellaenterica) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF08343(RNR_N) | 5 | GLY A 410GLY A 460ARG A 399HIS A 408ILE A 183 | None | 1.02A | 2b25B-1pemA:undetectable | 2b25B-1pemA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qwy | PEPTIDOGLYCANHYDROLASE (Staphylococcusaureus) |
PF01551(Peptidase_M23) | 5 | THR A 121SER A 237GLY A 242VAL A 232ILE A 247 | None | 1.02A | 2b25B-1qwyA:undetectable | 2b25B-1qwyA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s59 | NUCLEOSIDEDIPHOSPHATE KINASEII (Arabidopsisthaliana) |
PF00334(NDK) | 5 | THR A 86GLY A 198SER A 199VAL A 90ILE A 195 | None | 0.96A | 2b25B-1s59A:undetectable | 2b25B-1s59A:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5f | PYRUVATE OXIDASE (Aerococcusviridans) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | THR A 239SER A 280GLY A 279ASP A 91ILE A 97 | FAD A1601 (-2.8A)FAD A1601 (-2.6A)FAD A1601 (-3.5A)NoneNone | 1.10A | 2b25B-1v5fA:undetectable | 2b25B-1v5fA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wqa | PHOSPHO-SUGAR MUTASE (Pyrococcushorikoshii) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | GLY A 330GLY A 324VAL A 250ARG A 248ILE A 259 | GLY A 330 ( 0.0A)GLY A 324 ( 0.0A)VAL A 250 ( 0.6A)ARG A 248 (-0.6A)ILE A 259 ( 0.4A) | 0.95A | 2b25B-1wqaA:undetectable | 2b25B-1wqaA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wqa | PHOSPHO-SUGAR MUTASE (Pyrococcushorikoshii) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | THR A 283GLY A 330GLY A 324VAL A 250ILE A 259 | THR A 283 ( 0.8A)GLY A 330 ( 0.0A)GLY A 324 ( 0.0A)VAL A 250 ( 0.6A)ILE A 259 ( 0.4A) | 0.87A | 2b25B-1wqaA:undetectable | 2b25B-1wqaA:21.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2b25 | HYPOTHETICAL PROTEIN (Homo sapiens) |
PF08704(GCD14) | 6 | GLY A 113SER A 114GLY A 116ARG A 137HIS A 140ILE A 170 | SAM A 601 (-3.2A)SAM A 601 (-4.8A)SAM A 601 (-3.5A)NoneSAM A 601 (-4.0A)None | 1.22A | 2b25B-2b25A:37.0 | 2b25B-2b25A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2b25 | HYPOTHETICAL PROTEIN (Homo sapiens) |
PF08704(GCD14) | 5 | THR A 84SER A 114GLY A 115ARG A 137MET A 193 | SAM A 601 (-3.8A)SAM A 601 (-4.8A)SAM A 601 (-4.1A)NoneSAM A 601 ( 4.2A) | 1.16A | 2b25B-2b25A:37.0 | 2b25B-2b25A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2b25 | HYPOTHETICAL PROTEIN (Homo sapiens) |
PF08704(GCD14) | 12 | THR A 84THR A 87GLY A 113SER A 114GLY A 116MET A 117VAL A 136ARG A 137HIS A 140ASP A 173ILE A 174MET A 193 | SAM A 601 (-3.8A)SAM A 601 (-3.7A)SAM A 601 (-3.2A)SAM A 601 (-4.8A)SAM A 601 (-3.5A)NoneSAM A 601 (-4.0A)NoneSAM A 601 (-4.0A)SAM A 601 (-3.4A)SAM A 601 (-4.2A)SAM A 601 ( 4.2A) | 0.34A | 2b25B-2b25A:37.0 | 2b25B-2b25A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c4n | PROTEIN NAGD (Escherichiacoli) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 5 | THR A 119GLY A 91GLY A 93VAL A 114ILE A 141 | None | 1.18A | 2b25B-2c4nA:2.9 | 2b25B-2c4nA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cuc | SH3 DOMAINCONTAINING RINGFINGER 2 (Mus musculus) |
PF00018(SH3_1) | 5 | GLY A 7SER A 6GLY A 4VAL A 34ILE A 32 | None | 1.06A | 2b25B-2cucA:undetectable | 2b25B-2cucA:12.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dl4 | PROTEIN STAC (Homo sapiens) |
PF00018(SH3_1) | 5 | GLY A 7SER A 6GLY A 4ARG A 61ILE A 31 | None | 1.16A | 2b25B-2dl4A:undetectable | 2b25B-2dl4A:11.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0p | ENDOGLUCANASE (Ruminiclostridiumthermocellum) |
PF12891(Glyco_hydro_44) | 5 | THR A 390GLY A 45VAL A 279ASP A 278ILE A 227 | NoneCTT A 800 ( 3.7A)NoneNoneNone | 1.10A | 2b25B-2e0pA:undetectable | 2b25B-2e0pA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ew9 | COPPER-TRANSPORTINGATPASE 2 (Homo sapiens) |
PF00403(HMA) | 5 | GLY A 142GLY A 88MET A 89ASP A 133ILE A 134 | None | 1.15A | 2b25B-2ew9A:undetectable | 2b25B-2ew9A:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g8g | CAPSID (Adeno-associateddependoparvovirusA) |
PF00740(Parvo_coat) | 5 | SER A 630GLY A 634HIS A 628ILE A 478MET A 523 | D5M A 21 ( 4.3A)NoneD5M A 21 (-4.0A)NoneNone | 1.17A | 2b25B-2g8gA:undetectable | 2b25B-2g8gA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ory | LIPASE (Photobacteriumsp. M37) |
PF01764(Lipase_3) | 5 | GLY A 176SER A 174GLY A 208ARG A 90ILE A 87 | None | 1.17A | 2b25B-2oryA:undetectable | 2b25B-2oryA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rbc | SUGAR KINASE (Agrobacteriumfabrum) |
PF00294(PfkB) | 5 | GLY A 58MET A 57VAL A 139HIS A 9ILE A 164 | None | 1.06A | 2b25B-2rbcA:2.6 | 2b25B-2rbcA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxd | PROBABLECOBALT-PRECORRIN-6YC(15)-METHYLTRANSFERASE[DECARBOXYLATING] (Methanocaldococcusjannaschii) |
PF13847(Methyltransf_31) | 5 | THR A 19GLY A 45SER A 46GLY A 48MET A 49 | SO4 A1001 (-3.8A)SO4 A1001 ( 3.8A)SO4 A1001 (-4.5A)SO4 A1001 (-3.0A)None | 0.68A | 2b25B-2yxdA:17.8 | 2b25B-2yxdA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ai2 | NADPH-SORBOSEREDUCTASE (Gluconobacterfrateurii) |
PF13561(adh_short_C2) | 5 | SER A 6GLY A 4MET A 3HIS A 33ILE A 12 | None | 1.14A | 2b25B-3ai2A:6.3 | 2b25B-3ai2A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b1r | RIBOKINASE, PUTATIVE (Burkholderiathailandensis) |
PF00294(PfkB) | 5 | THR A 220GLY A 252GLY A 280MET A 279ILE A 5 | AMP A 502 (-3.4A)AMP A 502 (-3.6A)AMP A 502 (-3.3A)NoneNone | 1.03A | 2b25B-3b1rA:undetectable | 2b25B-3b1rA:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b5q | PUTATIVE SULFATASEYIDJ (Bacteroidesthetaiotaomicron) |
PF00884(Sulfatase)PF16347(DUF4976) | 5 | THR A 118GLY A 122VAL A 113HIS A 129ILE A 171 | None | 1.14A | 2b25B-3b5qA:undetectable | 2b25B-3b5qA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f4w | PUTATIVE HEXULOSE 6PHOSPHATE SYNTHASE (Salmonellaenterica) |
PF00215(OMPdecase) | 5 | THR A 137GLY A 187SER A 188GLY A 167ILE A 28 | MLI A 300 ( 4.6A)MLI A 300 (-3.3A)NoneMLI A 300 (-3.5A)None | 1.01A | 2b25B-3f4wA:undetectable | 2b25B-3f4wA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3giu | PYRROLIDONE-CARBOXYLATE PEPTIDASE (Staphylococcusaureus) |
PF01470(Peptidase_C15) | 5 | THR A 42GLY A 67ARG A 72HIS A 165ILE A 169 | ACY A 214 ( 3.5A)ACY A 214 (-3.6A)None ZN A 213 (-3.5A)None | 1.09A | 2b25B-3giuA:undetectable | 2b25B-3giuA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h7k | AGMATINE DEIMINASE (Arabidopsisthaliana) |
PF04371(PAD_porph) | 5 | THR A 221GLY A 223GLY A 217VAL A 176HIS A 224 | AGT A 366 ( 4.5A)None NA A 387 (-3.7A)NoneAGT A 366 ( 4.1A) | 1.16A | 2b25B-3h7kA:undetectable | 2b25B-3h7kA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hbj | FLAVONOID3-O-GLUCOSYLTRANSFERASE (Medicagotruncatula) |
PF00201(UDPGT) | 5 | THR A 384GLY A 393GLY A 391MET A 368VAL A 398 | None | 1.13A | 2b25B-3hbjA:3.9 | 2b25B-3hbjA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hid | ADENYLOSUCCINATESYNTHETASE (Yersinia pestis) |
PF00709(Adenylsucc_synt) | 5 | GLY A 252SER A 253GLY A 70ASP A 232ILE A 231 | None | 1.14A | 2b25B-3hidA:2.2 | 2b25B-3hidA:25.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3imf | SHORT CHAINDEHYDROGENASE (Bacillusanthracis) |
PF13561(adh_short_C2) | 5 | GLY A 11SER A 12GLY A 14MET A 15ILE A 83 | None | 0.83A | 2b25B-3imfA:5.9 | 2b25B-3imfA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khk | TYPE IRESTRICTION-MODIFICATION SYSTEMMETHYLATION SUBUNIT (Methanosarcinamazei) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 5 | THR A 228GLY A 253SER A 254GLY A 256ASP A 317 | None | 0.75A | 2b25B-3khkA:10.3 | 2b25B-3khkA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kl4 | SIGNAL RECOGNITION54 KDA PROTEIN (Sulfolobussolfataricus) |
PF00448(SRP54)PF02881(SRP54_N)PF02978(SRP_SPB) | 5 | THR A 263SER A 231HIS A 234ASP A 213ILE A 215 | None | 1.04A | 2b25B-3kl4A:undetectable | 2b25B-3kl4A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l3s | ENOYL-COAHYDRATASE/ISOMERASEFAMILY PROTEIN (Ruegeriapomeroyi) |
PF00378(ECH_1) | 5 | GLY A 114GLY A 59ARG A 137ASP A 178ILE A 189 | None | 1.07A | 2b25B-3l3sA:undetectable | 2b25B-3l3sA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lga | SAM-DEPENDENTMETHYLTRANSFERASE (Pyrococcusabyssi) |
PF08704(GCD14)PF14801(GCD14_N) | 5 | GLY A 103SER A 104ARG A 127ASP A 153ILE A 154 | SAH A 301 (-3.5A)SAH A 301 (-4.4A)NoneSAH A 301 (-3.1A)SAH A 301 (-4.3A) | 0.44A | 2b25B-3lgaA:25.2 | 2b25B-3lgaA:28.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8o | 6-PHOSPHOFRUCTOKINASE SUBUNIT BETA (Saccharomycescerevisiae) |
PF00365(PFK) | 5 | GLY B 345SER B 346GLY B 359VAL B 297ILE B 218 | NoneF6P B 980 ( 4.4A)NoneNoneNone | 1.12A | 2b25B-3o8oB:undetectable | 2b25B-3o8oB:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3opy | 6-PHOSPHOFRUCTO-1-KINASE ALPHA-SUBUNIT (Komagataellapastoris) |
PF00365(PFK) | 5 | GLY A 358SER A 359GLY A 372VAL A 310ILE A 215 | NoneSO4 A 991 (-3.4A)NoneNoneNone | 1.07A | 2b25B-3opyA:undetectable | 2b25B-3opyA:16.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8r | GERANYLTRANSTRANSFERASE (Vibrio cholerae) |
PF00348(polyprenyl_synt) | 5 | GLY A 37VAL A 71ARG A 46HIS A 75ILE A 122 | None | 1.17A | 2b25B-3p8rA:undetectable | 2b25B-3p8rA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qgu | LL-DIAMINOPIMELATEAMINOTRANSFERASE (Chlamydomonasreinhardtii) |
PF00155(Aminotran_1_2) | 5 | THR A 287GLY A 77GLY A 285VAL A 400ILE A 72 | SO4 A 450 ( 4.6A)NoneNoneNoneNone | 1.15A | 2b25B-3qguA:2.3 | 2b25B-3qguA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r9l | NUCLEOSIDEDIPHOSPHATE KINASE (Giardiaintestinalis) |
PF00334(NDK) | 5 | THR A 6GLY A 118SER A 119VAL A 10ILE A 115 | None | 0.94A | 2b25B-3r9lA:undetectable | 2b25B-3r9lA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rj8 | CARBOHYDRATE OXIDASE (Microdochiumnivale) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | GLY A 191SER A 192GLY A 195VAL A 157ASP A 158 | NoneFAD A 501 (-4.0A)NoneNoneNone | 1.19A | 2b25B-3rj8A:undetectable | 2b25B-3rj8A:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rpc | POSSIBLEMETAL-DEPENDENTHYDROLASE (Veillonellaparvula) |
PF12706(Lactamase_B_2) | 5 | THR A 68THR A 125GLY A 164GLY A 127VAL A 222 | None | 1.15A | 2b25B-3rpcA:undetectable | 2b25B-3rpcA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3syj | ADHESION ANDPENETRATION PROTEINAUTOTRANSPORTER (Haemophilusinfluenzae) |
PF02395(Peptidase_S6)PF03212(Pertactin) | 5 | GLY A 26GLY A 180ARG A 187HIS A 27ILE A 32 | None | 1.12A | 2b25B-3syjA:undetectable | 2b25B-3syjA:16.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4a | JMB19063 (compostmetagenome) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | THR A 244GLY A 287GLY A 238ASP A 316ILE A 315 | None | 1.15A | 2b25B-3u4aA:undetectable | 2b25B-3u4aA:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ufx | SUCCINYL-COASYNTHETASE BETASUBUNIT (Thermusaquaticus) |
PF00549(Ligase_CoA)PF08442(ATP-grasp_2) | 5 | THR B 370GLY B 251GLY B 304ASP B 279ILE B 280 | None | 1.19A | 2b25B-3ufxB:undetectable | 2b25B-3ufxB:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vc7 | PUTATIVEOXIDOREDUCTASE (Sinorhizobiummeliloti) |
PF13561(adh_short_C2) | 5 | THR A 186GLY A 18MET A 19ASP A 61ILE A 62 | None | 1.18A | 2b25B-3vc7A:6.8 | 2b25B-3vc7A:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vf1 | 11R-LIPOXYGENASE (Gersemiafruticosa) |
PF00305(Lipoxygenase)PF01477(PLAT) | 5 | THR A 566GLY A 245SER A 246ASP A 324ILE A 325 | None | 1.18A | 2b25B-3vf1A:undetectable | 2b25B-3vf1A:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w4k | D-AMINO-ACID OXIDASE (Homo sapiens) |
PF01266(DAO) | 5 | THR A 44GLY A 281GLY A 198ARG A 279ILE A 259 | FAD A 401 (-4.0A)FAD A 401 (-4.3A)NoneNoneNone | 1.18A | 2b25B-3w4kA:3.0 | 2b25B-3w4kA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w9i | MULTIDRUG RESISTANCEPROTEIN MEXB (Pseudomonasaeruginosa) |
PF00873(ACR_tran) | 5 | THR A 56SER A 53GLY A 86VAL A 749ILE A 751 | None | 1.17A | 2b25B-3w9iA:undetectable | 2b25B-3w9iA:14.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aty | TEREPHTHALATE1,2-CIS-DIHYDRODIOLDEHYDROGENASE (Paraburkholderiaxenovorans) |
PF04166(PdxA) | 5 | THR A 343GLY A 337VAL A 57ASP A 95ILE A 94 | None | 1.05A | 2b25B-4atyA:undetectable | 2b25B-4atyA:24.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c4v | OUTER MEMBRANEPROTEIN ASSEMBLYFACTOR BAMA (Escherichiacoli) |
PF01103(Bac_surface_Ag)PF07244(POTRA) | 5 | THR A 612GLY A 636GLY A 638VAL A 713ILE A 668 | None | 1.17A | 2b25B-4c4vA:undetectable | 2b25B-4c4vA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fgs | PROBABLEDEHYDROGENASEPROTEIN (Rhizobium etli) |
PF13561(adh_short_C2) | 5 | GLY A 137SER A 138GLY A 141VAL A 134ILE A 176 | None | 1.16A | 2b25B-4fgsA:6.8 | 2b25B-4fgsA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4flm | S-FORMYLGLUTATHIONEHYDROLASE (Saccharomycescerevisiae) |
PF00756(Esterase) | 5 | GLY A 57SER A 56GLY A 159ASP A 103ILE A 197 | SDP A 161 ( 3.5A)NoneNoneNoneNone | 0.92A | 2b25B-4flmA:undetectable | 2b25B-4flmA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4irt | UNCHARACTERIZEDPROTEIN (Bacteroidesovatus) |
PF15892(BNR_4) | 5 | GLY A 161SER A 162GLY A 164ASP A 185ILE A 186 | None | 1.12A | 2b25B-4irtA:undetectable | 2b25B-4irtA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jb6 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Pseudomonasaeruginosa) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | THR A 168THR A 162GLY A 405SER A 397GLY A 399 | NoneNoneNone K A 501 ( 4.6A)None | 0.92A | 2b25B-4jb6A:undetectable | 2b25B-4jb6A:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jo0 | CMLA (Streptomycesvenezuelae) |
PF12706(Lactamase_B_2) | 5 | THR A 405GLY A 460SER A 461GLY A 428ILE A 439 | None | 1.17A | 2b25B-4jo0A:undetectable | 2b25B-4jo0A:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jro | FABG PROTEIN (Listeriamonocytogenes) |
PF13561(adh_short_C2) | 5 | GLY A 13SER A 14GLY A 16VAL A 9ILE A 86 | None | 1.14A | 2b25B-4jroA:6.3 | 2b25B-4jroA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nf2 | ORNITHINECARBAMOYLTRANSFERASE (Bacillusanthracis) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | SER A 63GLY A 67MET A 68ASP A 54ILE A 52 | None | 1.18A | 2b25B-4nf2A:3.8 | 2b25B-4nf2A:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qa9 | EPOXIDE HYDROLASE (Streptomycescarzinostaticus) |
PF06441(EHN) | 5 | THR A 293GLY A 137GLY A 135VAL A 103ILE A 130 | None | 1.16A | 2b25B-4qa9A:undetectable | 2b25B-4qa9A:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r37 | PUTATIVEACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Bacteroidesfragilis) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | GLY A 113SER A 131GLY A 129VAL A 61ILE A 56 | None | 1.12A | 2b25B-4r37A:undetectable | 2b25B-4r37A:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ruh | CYTOSOLICNON-SPECIFICDIPEPTIDASE (Homo sapiens) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | GLY A 129SER A 130GLY A 135VAL A 31ILE A 41 | None | 1.15A | 2b25B-4ruhA:undetectable | 2b25B-4ruhA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uoh | NUCLEOSIDEDIPHOSPHATE KINASE (Litopenaeusvannamei) |
PF00334(NDK) | 5 | THR A 6GLY A 118SER A 119VAL A 10ILE A 115 | None | 0.98A | 2b25B-4uohA:undetectable | 2b25B-4uohA:16.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wct | FRUCTOSYLAMINE:OXYGENOXIDOREDUCTASE (Aspergillusfumigatus) |
PF01266(DAO) | 5 | THR A 347GLY A 368GLY A 371VAL A 365ILE A 384 | NoneNoneFAD A 500 (-3.7A)NoneNone | 1.07A | 2b25B-4wctA:undetectable | 2b25B-4wctA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yac | CALPHA-DEHYDROGENASE (Sphingobium sp.SYK-6) |
PF00106(adh_short) | 5 | GLY A 15GLY A 21ARG A 40HIS A 43ASP A 64 | NAI A 500 ( 4.2A)NoneNoneNAI A 500 (-3.5A)NAI A 500 (-3.6A) | 1.16A | 2b25B-4yacA:6.4 | 2b25B-4yacA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5amz | THAUMATIN-1 (Thaumatococcusdaniellii) |
PF00314(Thaumatin) | 5 | THR A 68GLY A 107GLY A 144ASP A 101ILE A 102 | None | 1.19A | 2b25B-5amzA:undetectable | 2b25B-5amzA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bxi | NUCLEOSIDEDIPHOSPHATE KINASE (Toxoplasmagondii) |
PF00334(NDK) | 5 | THR A 9GLY A 121SER A 122VAL A 13ILE A 118 | None | 0.96A | 2b25B-5bxiA:undetectable | 2b25B-5bxiA:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c1i | TRNA(ADENINE(58)-N(1))-METHYLTRANSFERASETRMI (Thermusthermophilus) |
PF08704(GCD14) | 5 | GLY A 103SER A 104GLY A 106ARG A 127HIS A 130 | None | 1.13A | 2b25B-5c1iA:27.0 | 2b25B-5c1iA:29.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c1i | TRNA(ADENINE(58)-N(1))-METHYLTRANSFERASETRMI (Thermusthermophilus) |
PF08704(GCD14) | 5 | THR A 77GLY A 103SER A 104GLY A 106HIS A 130 | None | 0.97A | 2b25B-5c1iA:27.0 | 2b25B-5c1iA:29.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c92 | KELCHDOMAIN-CONTAININGPROTEIN (Colletotrichumgraminicola) |
PF01344(Kelch_1)PF09118(DUF1929) | 5 | GLY A 279SER A 250GLY A 242MET A 222VAL A 294 | None | 1.07A | 2b25B-5c92A:undetectable | 2b25B-5c92A:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ccx | TRNA(ADENINE(58)-N(1))-METHYLTRANSFERASECATALYTIC SUBUNITTRMT61A (Homo sapiens) |
PF08704(GCD14) | 5 | THR A 84GLY A 113SER A 114GLY A 115ASP A 163 | SAH A 301 (-3.4A)SAH A 301 (-2.9A)SAH A 301 (-4.4A)SAH A 301 (-3.9A)SAH A 301 (-2.7A) | 0.93A | 2b25B-5ccxA:24.2 | 2b25B-5ccxA:25.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5esr | HALOALKANEDEHALOGENASE (Caulobactervibrioides) |
PF00561(Abhydrolase_1) | 5 | THR A 148GLY A 126GLY A 54VAL A 133ILE A 117 | None | 0.79A | 2b25B-5esrA:undetectable | 2b25B-5esrA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fji | BETA-GLUCOSIDASE (Aspergillusfumigatus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | GLY A 346GLY A 184ARG A 46ILE A 85MET A 339 | EDO A1876 (-3.6A)EDO A1880 ( 4.3A)EDO A1876 (-3.9A)NoneNone | 1.13A | 2b25B-5fjiA:undetectable | 2b25B-5fjiA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gju | ATP-DEPENDENT RNAHELICASE DEAD (Escherichiacoli) |
PF00270(DEAD) | 5 | GLY A 152SER A 151GLY A 180VAL A 79ASP A 156 | None | 0.97A | 2b25B-5gjuA:undetectable | 2b25B-5gjuA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hdf | HYDROLASE (Streptomycesflocculus) |
no annotation | 5 | THR B 207GLY B 183SER B 188GLY B 101VAL B 180 | None | 1.10A | 2b25B-5hdfB:undetectable | 2b25B-5hdfB:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ix8 | PUTATIVE SUGAR ABCTRANSPORT SYSTEM,SUBSTRATE-BINDINGPROTEIN (Bordetellaparapertussis) |
PF13407(Peripla_BP_4) | 5 | THR A 245THR A 230GLY A 251GLY A 226MET A 227 | None | 0.88A | 2b25B-5ix8A:2.1 | 2b25B-5ix8A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kob | PEPTIDE DEFORMYLASE (Paraburkholderiaxenovorans) |
PF01327(Pep_deformylase) | 5 | THR A 164GLY A 98GLY A 104VAL A 138ARG A 137 | NoneFMT A 202 ( 4.3A)NoneFMT A 202 ( 3.9A)None | 1.16A | 2b25B-5kobA:undetectable | 2b25B-5kobA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5le9 | DD_OFF7_09_3G124 (syntheticconstruct) |
PF00023(Ank)PF12796(Ank_2) | 5 | GLY A 180GLY A 213ARG A 184HIS A 181ILE A 189 | None | 1.08A | 2b25B-5le9A:undetectable | 2b25B-5le9A:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n94 | CG9323, ISOFORM A (Drosophilamelanogaster) |
no annotation | 5 | THR A 312GLY A 176SER A 177GLY A 332ILE A 162 | None | 1.16A | 2b25B-5n94A:undetectable | 2b25B-5n94A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vh6 | ELONGATION FACTOR G (Bacillussubtilis) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2) | 5 | THR A 26GLY A 259SER A 260ASP A 177ILE A 162 | None | 1.14A | 2b25B-5vh6A:undetectable | 2b25B-5vh6A:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtd | NADH DEHYDROGENASE[UBIQUINONE] 1 ALPHASUBCOMPLEX SUBUNIT9, MITOCHONDRIAL (Homo sapiens) |
PF01370(Epimerase) | 5 | THR J 235GLY J 229SER J 230GLY J 232ILE J 314 | None | 0.96A | 2b25B-5xtdJ:undetectable | 2b25B-5xtdJ:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xvd | HYDROGENASE-2 SMALLCHAIN (Citrobacter sp.MGH106) |
no annotation | 5 | GLY S 118SER S 119GLY S 125VAL S 79ILE S 17 | 8JU S 404 (-3.6A)8JU S 404 ( 4.9A)NoneNoneNone | 1.16A | 2b25B-5xvdS:undetectable | 2b25B-5xvdS:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y6t | ENDO-1,4-BETA-MANNANASE (Eisenia fetida) |
no annotation | 5 | GLY A 308GLY A 334MET A 36HIS A 278ILE A 41 | None | 1.09A | 2b25B-5y6tA:undetectable | 2b25B-5y6tA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y8p | PROBABLE3-HYDROXYISOBUTYRATEDEHYDROGENASE (Mycobacteriumtuberculosis) |
no annotation | 5 | GLY A 8GLY A 10MET A 12VAL A 61ILE A 89 | None | 1.13A | 2b25B-5y8pA:5.5 | 2b25B-5y8pA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z9s | GLYCOSYL HYDROLASEFAMILY 3 PROTEIN (Bifidobacteriumlongum) |
no annotation | 5 | THR A 144GLY A 100SER A 102HIS A 99ILE A 377 | None | 1.17A | 2b25B-5z9sA:undetectable | 2b25B-5z9sA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b9u | DNA GYRASE, SUBUNITB:SHORT-CHAINDEHYDROGENASE/REDUCTASESDR:GLUCOSE/RIBITOLDEHYDROGENASE (Brucellaabortus) |
no annotation | 5 | GLY A 15GLY A 21MET A 22ASP A 60ILE A 61 | NAI A 301 ( 4.3A)NoneNoneNAI A 301 (-3.4A)NAI A 301 (-3.9A) | 1.12A | 2b25B-6b9uA:5.7 | 2b25B-6b9uA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bk6 | HENDRA VIRUS MATRIXPROTEIN (Hendrahenipavirus) |
no annotation | 5 | THR A 179GLY A 269SER A 270GLY A 272ILE A 278 | None | 0.89A | 2b25B-6bk6A:undetectable | 2b25B-6bk6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bk6 | HENDRA VIRUS MATRIXPROTEIN (Hendrahenipavirus) |
no annotation | 5 | THR A 179GLY A 269SER A 270GLY A 273ILE A 278 | None | 0.92A | 2b25B-6bk6A:undetectable | 2b25B-6bk6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bk7 | ELONGATION FACTOR G (Enterococcusfaecalis) |
no annotation | 5 | THR A 26GLY A 259SER A 260ASP A 177ILE A 162 | None | 1.05A | 2b25B-6bk7A:undetectable | 2b25B-6bk7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fdf | TRNA(CYTOSINE(38)-C(5))-METHYLTRANSFERASE (Schizosaccharomycespombe) |
no annotation | 5 | GLY A 15GLY A 18MET A 19ASP A 58ILE A 59 | SAH A 401 (-3.4A)SAH A 401 (-3.6A)NoneSAH A 401 (-3.8A)SAH A 401 (-3.7A) | 0.85A | 2b25B-6fdfA:7.3 | 2b25B-6fdfA:undetectable |