SIMILAR PATTERNS OF AMINO ACIDS FOR 2B25_B_SAMB602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		5 THR A 150
THR A 398
SER A 145
GLY A 402
ILE A 472
 None
 1.07A 2b25B-1a6dA:
undetectable		 2b25B-1a6dA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aun PR-5D

(Nicotiana
tabacum) 		PF00314
(Thaumatin) 		5 THR A  64
GLY A 104
GLY A 143
ASP A  98
ILE A  99
 None
 1.16A 2b25B-1aunA:
undetectable		 2b25B-1aunA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		5 GLY A 251
SER A 252
GLY A  69
ASP A 231
ILE A 230
 None
 1.10A 2b25B-1cg4A:
undetectable		 2b25B-1cg4A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 GLY A 866
GLY A 625
VAL A 804
ASP A 805
ILE A 808
 MCN  A 914 (-3.6A)
None
MCN  A 914 (-4.6A)
None
None
 1.05A 2b25B-1dgjA:
undetectable		 2b25B-1dgjA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dix EXTRACELLULAR
RIBONUCLEASE LE

(Solanum
lycopersicum) 		PF00445
(Ribonuclease_T2) 		5 THR A  29
GLY A  84
ASP A  67
ILE A  65
MET A  72
 None
 1.09A 2b25B-1dixA:
undetectable		 2b25B-1dixA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2

(Homo sapiens) 		PF00145
(DNA_methylase) 		5 GLY A  12
GLY A  15
MET A  16
VAL A  35
ILE A  57
 SAH  A 392 (-3.4A)
SAH  A 392 (-3.1A)
None
SAH  A 392 (-3.9A)
SAH  A 392 (-4.1A)
 0.71A 2b25B-1g55A:
7.7		 2b25B-1g55A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		5 THR A 432
GLY A 429
GLY A 442
VAL A  10
ILE A  33
 None
FAD  A 579 (-3.1A)
None
FAD  A 579 (-4.6A)
None
 1.17A 2b25B-1h81A:
undetectable		 2b25B-1h81A:
22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		6 GLY A 109
SER A 110
ARG A 133
HIS A 136
ASP A 161
MET A 179
 SAM  A 301 (-3.4A)
SAM  A 301 (-4.4A)
None
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.7A)
 0.58A 2b25B-1i9gA:
27.3		 2b25B-1i9gA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		6 GLY A 109
SER A 110
GLY A 111
ARG A 133
HIS A 136
MET A 179
 SAM  A 301 (-3.4A)
SAM  A 301 (-4.4A)
SAM  A 301 (-4.2A)
None
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
 1.04A 2b25B-1i9gA:
27.3		 2b25B-1i9gA:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME BETA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome) 		5 THR H   1
GLY H 128
SER H 129
VAL H  97
ILE H 113
 CIB  H1001 (-1.9A)
None
CIB  H1001 ( 4.8A)
None
None
 1.15A 2b25B-1j2qH:
undetectable		 2b25B-1j2qH:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8t AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Enterococcus
faecalis) 		PF01636
(APH) 		5 THR A  54
GLY A 189
SER A 212
HIS A 188
ILE A 258
 None
 1.16A 2b25B-1l8tA:
undetectable		 2b25B-1l8tA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1leo NUCLEOSIDE
DIPHOSPHATE KINASE

(Dictyostelium
discoideum) 		PF00334
(NDK) 		5 THR A  11
GLY A 123
SER A 124
VAL A  15
ILE A 120
 None
 0.96A 2b25B-1leoA:
undetectable		 2b25B-1leoA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwd ISOCITRATE
DEHYDROGENASE

(Sus scrofa) 		PF00180
(Iso_dh) 		5 GLY A 263
SER A 262
GLY A 124
VAL A 266
ILE A 131
 None
 1.03A 2b25B-1lwdA:
undetectable		 2b25B-1lwdA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndl NUCLEOSIDE
DIPHOSPHATE KINASE

(Drosophila
melanogaster) 		PF00334
(NDK) 		5 THR A   8
GLY A 120
SER A 121
VAL A  12
ILE A 117
 None
 0.94A 2b25B-1ndlA:
undetectable		 2b25B-1ndlA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		5 THR A 145
GLY A 141
SER A 142
GLY A  96
ILE A 218
 NAP  A1800 (-3.2A)
None
NAP  A1800 (-3.3A)
NAP  A1800 (-3.3A)
None
 1.15A 2b25B-1o2dA:
undetectable		 2b25B-1o2dA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		5 GLY A 410
GLY A 460
ARG A 399
HIS A 408
ILE A 183
 None
 1.02A 2b25B-1pemA:
undetectable		 2b25B-1pemA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwy PEPTIDOGLYCAN
HYDROLASE

(Staphylococcus
aureus) 		PF01551
(Peptidase_M23) 		5 THR A 121
SER A 237
GLY A 242
VAL A 232
ILE A 247
 None
 1.02A 2b25B-1qwyA:
undetectable		 2b25B-1qwyA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s59 NUCLEOSIDE
DIPHOSPHATE KINASE
II

(Arabidopsis
thaliana) 		PF00334
(NDK) 		5 THR A  86
GLY A 198
SER A 199
VAL A  90
ILE A 195
 None
 0.96A 2b25B-1s59A:
undetectable		 2b25B-1s59A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5f PYRUVATE OXIDASE

(Aerococcus
viridans) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 THR A 239
SER A 280
GLY A 279
ASP A  91
ILE A  97
 FAD  A1601 (-2.8A)
FAD  A1601 (-2.6A)
FAD  A1601 (-3.5A)
None
None
 1.10A 2b25B-1v5fA:
undetectable		 2b25B-1v5fA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 GLY A 330
GLY A 324
VAL A 250
ARG A 248
ILE A 259
 GLY  A 330 ( 0.0A)
GLY  A 324 ( 0.0A)
VAL  A 250 ( 0.6A)
ARG  A 248 (-0.6A)
ILE  A 259 ( 0.4A)
 0.95A 2b25B-1wqaA:
undetectable		 2b25B-1wqaA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 THR A 283
GLY A 330
GLY A 324
VAL A 250
ILE A 259
 THR  A 283 ( 0.8A)
GLY  A 330 ( 0.0A)
GLY  A 324 ( 0.0A)
VAL  A 250 ( 0.6A)
ILE  A 259 ( 0.4A)
 0.87A 2b25B-1wqaA:
undetectable		 2b25B-1wqaA:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		6 GLY A 113
SER A 114
GLY A 116
ARG A 137
HIS A 140
ILE A 170
 SAM  A 601 (-3.2A)
SAM  A 601 (-4.8A)
SAM  A 601 (-3.5A)
None
SAM  A 601 (-4.0A)
None
 1.22A 2b25B-2b25A:
37.0		 2b25B-2b25A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		5 THR A  84
SER A 114
GLY A 115
ARG A 137
MET A 193
 SAM  A 601 (-3.8A)
SAM  A 601 (-4.8A)
SAM  A 601 (-4.1A)
None
SAM  A 601 ( 4.2A)
 1.16A 2b25B-2b25A:
37.0		 2b25B-2b25A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		12 THR A  84
THR A  87
GLY A 113
SER A 114
GLY A 116
MET A 117
VAL A 136
ARG A 137
HIS A 140
ASP A 173
ILE A 174
MET A 193
 SAM  A 601 (-3.8A)
SAM  A 601 (-3.7A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.8A)
SAM  A 601 (-3.5A)
None
SAM  A 601 (-4.0A)
None
SAM  A 601 (-4.0A)
SAM  A 601 (-3.4A)
SAM  A 601 (-4.2A)
SAM  A 601 ( 4.2A)
 0.34A 2b25B-2b25A:
37.0		 2b25B-2b25A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4n PROTEIN NAGD

(Escherichia
coli) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 THR A 119
GLY A  91
GLY A  93
VAL A 114
ILE A 141
 None
 1.18A 2b25B-2c4nA:
2.9		 2b25B-2c4nA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuc SH3 DOMAIN
CONTAINING RING
FINGER 2

(Mus musculus) 		PF00018
(SH3_1) 		5 GLY A   7
SER A   6
GLY A   4
VAL A  34
ILE A  32
 None
 1.06A 2b25B-2cucA:
undetectable		 2b25B-2cucA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dl4 PROTEIN STAC

(Homo sapiens) 		PF00018
(SH3_1) 		5 GLY A   7
SER A   6
GLY A   4
ARG A  61
ILE A  31
 None
 1.16A 2b25B-2dl4A:
undetectable		 2b25B-2dl4A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		5 THR A 390
GLY A  45
VAL A 279
ASP A 278
ILE A 227
 None
CTT  A 800 ( 3.7A)
None
None
None
 1.10A 2b25B-2e0pA:
undetectable		 2b25B-2e0pA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew9 COPPER-TRANSPORTING
ATPASE 2

(Homo sapiens) 		PF00403
(HMA) 		5 GLY A 142
GLY A  88
MET A  89
ASP A 133
ILE A 134
 None
 1.15A 2b25B-2ew9A:
undetectable		 2b25B-2ew9A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8g CAPSID

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		5 SER A 630
GLY A 634
HIS A 628
ILE A 478
MET A 523
 D5M  A  21 ( 4.3A)
None
D5M  A  21 (-4.0A)
None
None
 1.17A 2b25B-2g8gA:
undetectable		 2b25B-2g8gA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ory LIPASE

(Photobacterium
sp. M37) 		PF01764
(Lipase_3) 		5 GLY A 176
SER A 174
GLY A 208
ARG A  90
ILE A  87
 None
 1.17A 2b25B-2oryA:
undetectable		 2b25B-2oryA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		5 GLY A  58
MET A  57
VAL A 139
HIS A   9
ILE A 164
 None
 1.06A 2b25B-2rbcA:
2.6		 2b25B-2rbcA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]

(Methanocaldococcus
jannaschii) 		PF13847
(Methyltransf_31) 		5 THR A  19
GLY A  45
SER A  46
GLY A  48
MET A  49
 SO4  A1001 (-3.8A)
SO4  A1001 ( 3.8A)
SO4  A1001 (-4.5A)
SO4  A1001 (-3.0A)
None
 0.68A 2b25B-2yxdA:
17.8		 2b25B-2yxdA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai2 NADPH-SORBOSE
REDUCTASE

(Gluconobacter
frateurii) 		PF13561
(adh_short_C2) 		5 SER A   6
GLY A   4
MET A   3
HIS A  33
ILE A  12
 None
 1.14A 2b25B-3ai2A:
6.3		 2b25B-3ai2A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		5 THR A 220
GLY A 252
GLY A 280
MET A 279
ILE A   5
 AMP  A 502 (-3.4A)
AMP  A 502 (-3.6A)
AMP  A 502 (-3.3A)
None
None
 1.03A 2b25B-3b1rA:
undetectable		 2b25B-3b1rA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5q PUTATIVE SULFATASE
YIDJ

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 THR A 118
GLY A 122
VAL A 113
HIS A 129
ILE A 171
 None
 1.14A 2b25B-3b5qA:
undetectable		 2b25B-3b5qA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4w PUTATIVE HEXULOSE 6
PHOSPHATE SYNTHASE

(Salmonella
enterica) 		PF00215
(OMPdecase) 		5 THR A 137
GLY A 187
SER A 188
GLY A 167
ILE A  28
 MLI  A 300 ( 4.6A)
MLI  A 300 (-3.3A)
None
MLI  A 300 (-3.5A)
None
 1.01A 2b25B-3f4wA:
undetectable		 2b25B-3f4wA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3giu PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Staphylococcus
aureus) 		PF01470
(Peptidase_C15) 		5 THR A  42
GLY A  67
ARG A  72
HIS A 165
ILE A 169
 ACY  A 214 ( 3.5A)
ACY  A 214 (-3.6A)
None
ZN  A 213 (-3.5A)
None
 1.09A 2b25B-3giuA:
undetectable		 2b25B-3giuA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7k AGMATINE DEIMINASE

(Arabidopsis
thaliana) 		PF04371
(PAD_porph) 		5 THR A 221
GLY A 223
GLY A 217
VAL A 176
HIS A 224
 AGT  A 366 ( 4.5A)
None
NA  A 387 (-3.7A)
None
AGT  A 366 ( 4.1A)
 1.16A 2b25B-3h7kA:
undetectable		 2b25B-3h7kA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		5 THR A 384
GLY A 393
GLY A 391
MET A 368
VAL A 398
 None
 1.13A 2b25B-3hbjA:
3.9		 2b25B-3hbjA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		5 GLY A 252
SER A 253
GLY A  70
ASP A 232
ILE A 231
 None
 1.14A 2b25B-3hidA:
2.2		 2b25B-3hidA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imf SHORT CHAIN
DEHYDROGENASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		5 GLY A  11
SER A  12
GLY A  14
MET A  15
ILE A  83
 None
 0.83A 2b25B-3imfA:
5.9		 2b25B-3imfA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT

(Methanosarcina
mazei) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 THR A 228
GLY A 253
SER A 254
GLY A 256
ASP A 317
 None
 0.75A 2b25B-3khkA:
10.3		 2b25B-3khkA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN

(Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 THR A 263
SER A 231
HIS A 234
ASP A 213
ILE A 215
 None
 1.04A 2b25B-3kl4A:
undetectable		 2b25B-3kl4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3s ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Ruegeria
pomeroyi) 		PF00378
(ECH_1) 		5 GLY A 114
GLY A  59
ARG A 137
ASP A 178
ILE A 189
 None
 1.07A 2b25B-3l3sA:
undetectable		 2b25B-3l3sA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		5 GLY A 103
SER A 104
ARG A 127
ASP A 153
ILE A 154
 SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
None
SAH  A 301 (-3.1A)
SAH  A 301 (-4.3A)
 0.44A 2b25B-3lgaA:
25.2		 2b25B-3lgaA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		5 GLY B 345
SER B 346
GLY B 359
VAL B 297
ILE B 218
 None
F6P  B 980 ( 4.4A)
None
None
None
 1.12A 2b25B-3o8oB:
undetectable		 2b25B-3o8oB:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 GLY A 358
SER A 359
GLY A 372
VAL A 310
ILE A 215
 None
SO4  A 991 (-3.4A)
None
None
None
 1.07A 2b25B-3opyA:
undetectable		 2b25B-3opyA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8r GERANYLTRANSTRANSFER
ASE

(Vibrio cholerae) 		PF00348
(polyprenyl_synt) 		5 GLY A  37
VAL A  71
ARG A  46
HIS A  75
ILE A 122
 None
 1.17A 2b25B-3p8rA:
undetectable		 2b25B-3p8rA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgu LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF00155
(Aminotran_1_2) 		5 THR A 287
GLY A  77
GLY A 285
VAL A 400
ILE A  72
 SO4  A 450 ( 4.6A)
None
None
None
None
 1.15A 2b25B-3qguA:
2.3		 2b25B-3qguA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9l NUCLEOSIDE
DIPHOSPHATE KINASE

(Giardia
intestinalis) 		PF00334
(NDK) 		5 THR A   6
GLY A 118
SER A 119
VAL A  10
ILE A 115
 None
 0.94A 2b25B-3r9lA:
undetectable		 2b25B-3r9lA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj8 CARBOHYDRATE OXIDASE

(Microdochium
nivale) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 GLY A 191
SER A 192
GLY A 195
VAL A 157
ASP A 158
 None
FAD  A 501 (-4.0A)
None
None
None
 1.19A 2b25B-3rj8A:
undetectable		 2b25B-3rj8A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpc POSSIBLE
METAL-DEPENDENT
HYDROLASE

(Veillonella
parvula) 		PF12706
(Lactamase_B_2) 		5 THR A  68
THR A 125
GLY A 164
GLY A 127
VAL A 222
 None
 1.15A 2b25B-3rpcA:
undetectable		 2b25B-3rpcA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 GLY A  26
GLY A 180
ARG A 187
HIS A  27
ILE A  32
 None
 1.12A 2b25B-3syjA:
undetectable		 2b25B-3syjA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 THR A 244
GLY A 287
GLY A 238
ASP A 316
ILE A 315
 None
 1.15A 2b25B-3u4aA:
undetectable		 2b25B-3u4aA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT

(Thermus
aquaticus) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		5 THR B 370
GLY B 251
GLY B 304
ASP B 279
ILE B 280
 None
 1.19A 2b25B-3ufxB:
undetectable		 2b25B-3ufxB:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc7 PUTATIVE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 THR A 186
GLY A  18
MET A  19
ASP A  61
ILE A  62
 None
 1.18A 2b25B-3vc7A:
6.8		 2b25B-3vc7A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 THR A 566
GLY A 245
SER A 246
ASP A 324
ILE A 325
 None
 1.18A 2b25B-3vf1A:
undetectable		 2b25B-3vf1A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4k D-AMINO-ACID OXIDASE

(Homo sapiens) 		PF01266
(DAO) 		5 THR A  44
GLY A 281
GLY A 198
ARG A 279
ILE A 259
 FAD  A 401 (-4.0A)
FAD  A 401 (-4.3A)
None
None
None
 1.18A 2b25B-3w4kA:
3.0		 2b25B-3w4kA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		5 THR A  56
SER A  53
GLY A  86
VAL A 749
ILE A 751
 None
 1.17A 2b25B-3w9iA:
undetectable		 2b25B-3w9iA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF04166
(PdxA) 		5 THR A 343
GLY A 337
VAL A  57
ASP A  95
ILE A  94
 None
 1.05A 2b25B-4atyA:
undetectable		 2b25B-4atyA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		5 THR A 612
GLY A 636
GLY A 638
VAL A 713
ILE A 668
 None
 1.17A 2b25B-4c4vA:
undetectable		 2b25B-4c4vA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgs PROBABLE
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		5 GLY A 137
SER A 138
GLY A 141
VAL A 134
ILE A 176
 None
 1.16A 2b25B-4fgsA:
6.8		 2b25B-4fgsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flm S-FORMYLGLUTATHIONE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF00756
(Esterase) 		5 GLY A  57
SER A  56
GLY A 159
ASP A 103
ILE A 197
 SDP  A 161 ( 3.5A)
None
None
None
None
 0.92A 2b25B-4flmA:
undetectable		 2b25B-4flmA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15892
(BNR_4) 		5 GLY A 161
SER A 162
GLY A 164
ASP A 185
ILE A 186
 None
 1.12A 2b25B-4irtA:
undetectable		 2b25B-4irtA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 THR A 168
THR A 162
GLY A 405
SER A 397
GLY A 399
 None
None
None
K  A 501 ( 4.6A)
None
 0.92A 2b25B-4jb6A:
undetectable		 2b25B-4jb6A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo0 CMLA

(Streptomyces
venezuelae) 		PF12706
(Lactamase_B_2) 		5 THR A 405
GLY A 460
SER A 461
GLY A 428
ILE A 439
 None
 1.17A 2b25B-4jo0A:
undetectable		 2b25B-4jo0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jro FABG PROTEIN

(Listeria
monocytogenes) 		PF13561
(adh_short_C2) 		5 GLY A  13
SER A  14
GLY A  16
VAL A   9
ILE A  86
 None
 1.14A 2b25B-4jroA:
6.3		 2b25B-4jroA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf2 ORNITHINE
CARBAMOYLTRANSFERASE

(Bacillus
anthracis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 SER A  63
GLY A  67
MET A  68
ASP A  54
ILE A  52
 None
 1.18A 2b25B-4nf2A:
3.8		 2b25B-4nf2A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qa9 EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		5 THR A 293
GLY A 137
GLY A 135
VAL A 103
ILE A 130
 None
 1.16A 2b25B-4qa9A:
undetectable		 2b25B-4qa9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r37 PUTATIVE
ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Bacteroides
fragilis) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 GLY A 113
SER A 131
GLY A 129
VAL A  61
ILE A  56
 None
 1.12A 2b25B-4r37A:
undetectable		 2b25B-4r37A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE

(Homo sapiens) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A 129
SER A 130
GLY A 135
VAL A  31
ILE A  41
 None
 1.15A 2b25B-4ruhA:
undetectable		 2b25B-4ruhA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoh NUCLEOSIDE
DIPHOSPHATE KINASE

(Litopenaeus
vannamei) 		PF00334
(NDK) 		5 THR A   6
GLY A 118
SER A 119
VAL A  10
ILE A 115
 None
 0.98A 2b25B-4uohA:
undetectable		 2b25B-4uohA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wct FRUCTOSYL
AMINE:OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		5 THR A 347
GLY A 368
GLY A 371
VAL A 365
ILE A 384
 None
None
FAD  A 500 (-3.7A)
None
None
 1.07A 2b25B-4wctA:
undetectable		 2b25B-4wctA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yac C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		5 GLY A  15
GLY A  21
ARG A  40
HIS A  43
ASP A  64
 NAI  A 500 ( 4.2A)
None
None
NAI  A 500 (-3.5A)
NAI  A 500 (-3.6A)
 1.16A 2b25B-4yacA:
6.4		 2b25B-4yacA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amz THAUMATIN-1

(Thaumatococcus
daniellii) 		PF00314
(Thaumatin) 		5 THR A  68
GLY A 107
GLY A 144
ASP A 101
ILE A 102
 None
 1.19A 2b25B-5amzA:
undetectable		 2b25B-5amzA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxi NUCLEOSIDE
DIPHOSPHATE KINASE

(Toxoplasma
gondii) 		PF00334
(NDK) 		5 THR A   9
GLY A 121
SER A 122
VAL A  13
ILE A 118
 None
 0.96A 2b25B-5bxiA:
undetectable		 2b25B-5bxiA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI

(Thermus
thermophilus) 		PF08704
(GCD14) 		5 GLY A 103
SER A 104
GLY A 106
ARG A 127
HIS A 130
 None
 1.13A 2b25B-5c1iA:
27.0		 2b25B-5c1iA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI

(Thermus
thermophilus) 		PF08704
(GCD14) 		5 THR A  77
GLY A 103
SER A 104
GLY A 106
HIS A 130
 None
 0.97A 2b25B-5c1iA:
27.0		 2b25B-5c1iA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola) 		PF01344
(Kelch_1)
PF09118
(DUF1929) 		5 GLY A 279
SER A 250
GLY A 242
MET A 222
VAL A 294
 None
 1.07A 2b25B-5c92A:
undetectable		 2b25B-5c92A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		5 THR A  84
GLY A 113
SER A 114
GLY A 115
ASP A 163
 SAH  A 301 (-3.4A)
SAH  A 301 (-2.9A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.9A)
SAH  A 301 (-2.7A)
 0.93A 2b25B-5ccxA:
24.2		 2b25B-5ccxA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esr HALOALKANE
DEHALOGENASE

(Caulobacter
vibrioides) 		PF00561
(Abhydrolase_1) 		5 THR A 148
GLY A 126
GLY A  54
VAL A 133
ILE A 117
 None
 0.79A 2b25B-5esrA:
undetectable		 2b25B-5esrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 346
GLY A 184
ARG A  46
ILE A  85
MET A 339
 EDO  A1876 (-3.6A)
EDO  A1880 ( 4.3A)
EDO  A1876 (-3.9A)
None
None
 1.13A 2b25B-5fjiA:
undetectable		 2b25B-5fjiA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gju ATP-DEPENDENT RNA
HELICASE DEAD

(Escherichia
coli) 		PF00270
(DEAD) 		5 GLY A 152
SER A 151
GLY A 180
VAL A  79
ASP A 156
 None
 0.97A 2b25B-5gjuA:
undetectable		 2b25B-5gjuA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdf HYDROLASE

(Streptomyces
flocculus) 		no annotation 5 THR B 207
GLY B 183
SER B 188
GLY B 101
VAL B 180
 None
 1.10A 2b25B-5hdfB:
undetectable		 2b25B-5hdfB:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN

(Bordetella
parapertussis) 		PF13407
(Peripla_BP_4) 		5 THR A 245
THR A 230
GLY A 251
GLY A 226
MET A 227
 None
 0.88A 2b25B-5ix8A:
2.1		 2b25B-5ix8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kob PEPTIDE DEFORMYLASE

(Paraburkholderia
xenovorans) 		PF01327
(Pep_deformylase) 		5 THR A 164
GLY A  98
GLY A 104
VAL A 138
ARG A 137
 None
FMT  A 202 ( 4.3A)
None
FMT  A 202 ( 3.9A)
None
 1.16A 2b25B-5kobA:
undetectable		 2b25B-5kobA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le9 DD_OFF7_09_3G124

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 GLY A 180
GLY A 213
ARG A 184
HIS A 181
ILE A 189
 None
 1.08A 2b25B-5le9A:
undetectable		 2b25B-5le9A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 5 THR A 312
GLY A 176
SER A 177
GLY A 332
ILE A 162
 None
 1.16A 2b25B-5n94A:
undetectable		 2b25B-5n94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vh6 ELONGATION FACTOR G

(Bacillus
subtilis) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 THR A  26
GLY A 259
SER A 260
ASP A 177
ILE A 162
 None
 1.14A 2b25B-5vh6A:
undetectable		 2b25B-5vh6A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Homo sapiens) 		PF01370
(Epimerase) 		5 THR J 235
GLY J 229
SER J 230
GLY J 232
ILE J 314
 None
 0.96A 2b25B-5xtdJ:
undetectable		 2b25B-5xtdJ:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvd HYDROGENASE-2 SMALL
CHAIN

(Citrobacter sp.
MGH106) 		no annotation 5 GLY S 118
SER S 119
GLY S 125
VAL S  79
ILE S  17
 8JU  S 404 (-3.6A)
8JU  S 404 ( 4.9A)
None
None
None
 1.16A 2b25B-5xvdS:
undetectable		 2b25B-5xvdS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6t ENDO-1,4-BETA-MANNAN
ASE

(Eisenia fetida) 		no annotation 5 GLY A 308
GLY A 334
MET A  36
HIS A 278
ILE A  41
 None
 1.09A 2b25B-5y6tA:
undetectable		 2b25B-5y6tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		no annotation 5 GLY A   8
GLY A  10
MET A  12
VAL A  61
ILE A  89
 None
 1.13A 2b25B-5y8pA:
5.5		 2b25B-5y8pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 5 THR A 144
GLY A 100
SER A 102
HIS A  99
ILE A 377
 None
 1.17A 2b25B-5z9sA:
undetectable		 2b25B-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9u DNA GYRASE, SUBUNIT
B:SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
abortus) 		no annotation 5 GLY A  15
GLY A  21
MET A  22
ASP A  60
ILE A  61
 NAI  A 301 ( 4.3A)
None
None
NAI  A 301 (-3.4A)
NAI  A 301 (-3.9A)
 1.12A 2b25B-6b9uA:
5.7		 2b25B-6b9uA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk6 HENDRA VIRUS MATRIX
PROTEIN

(Hendra
henipavirus) 		no annotation 5 THR A 179
GLY A 269
SER A 270
GLY A 272
ILE A 278
 None
 0.89A 2b25B-6bk6A:
undetectable		 2b25B-6bk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk6 HENDRA VIRUS MATRIX
PROTEIN

(Hendra
henipavirus) 		no annotation 5 THR A 179
GLY A 269
SER A 270
GLY A 273
ILE A 278
 None
 0.92A 2b25B-6bk6A:
undetectable		 2b25B-6bk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis) 		no annotation 5 THR A  26
GLY A 259
SER A 260
ASP A 177
ILE A 162
 None
 1.05A 2b25B-6bk7A:
undetectable		 2b25B-6bk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE

(Schizosaccharomyces
pombe) 		no annotation 5 GLY A  15
GLY A  18
MET A  19
ASP A  58
ILE A  59
 SAH  A 401 (-3.4A)
SAH  A 401 (-3.6A)
None
SAH  A 401 (-3.8A)
SAH  A 401 (-3.7A)
 0.85A 2b25B-6fdfA:
7.3		 2b25B-6fdfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7v CALCIUM VECTOR
PROTEIN

(Branchiostoma
lanceolatum) 		PF13499
(EF-hand_7) 		3 GLY A 101
GLU A 109
ASP A 102
 None
 0.64A 2b25B-1c7vA:
undetectable		 2b25B-1c7vA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbn MJ FIBRILLARIN
HOMOLOGUE

(Methanocaldococcus
jannaschii) 		PF01269
(Fibrillarin) 		3 GLY A  82
GLU A 105
ASP A 150
 None
 0.70A 2b25B-1fbnA:
14.1		 2b25B-1fbnA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 GLY A 393
GLU A 391
ASP A 394
 None
 0.58A 2b25B-1hplA:
undetectable		 2b25B-1hplA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		3 GLY A 107
GLU A 131
ASP A 178
 SAM  A 301 (-2.7A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.4A)
 0.20A 2b25B-1i9gA:
27.3		 2b25B-1i9gA:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		3 GLY A 138
GLU A 136
ASP A 139
 None
 0.68A 2b25B-1ikpA:
undetectable		 2b25B-1ikpA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLY A  98
GLU A 121
ASP A 170
 None
 0.62A 2b25B-1inlA:
10.5		 2b25B-1inlA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3v CAPSID PROTEIN VP2

(Ungulate
protoparvovirus
1) 		PF00740
(Parvo_coat) 		3 GLY A 300
GLU A 299
ASP A 301
 None
 0.70A 2b25B-1k3vA:
undetectable		 2b25B-1k3vA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khh GUANIDINOACETATE
METHYLTRANSFERASE

(Rattus
norvegicus) 		no annotation 3 GLY A  67
GLU A  89
ASP A 134
 SAH  A 236 (-3.3A)
SAH  A 236 (-2.8A)
SAH  A 236 (-3.4A)
 0.39A 2b25B-1khhA:
12.3		 2b25B-1khhA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLY A  82
GLU A 104
ASP A 158
 None
 0.68A 2b25B-1mjfA:
10.5		 2b25B-1mjfA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN

(Archaeoglobus
fulgidus) 		PF01269
(Fibrillarin) 		3 GLY A  65
GLU A  88
ASP A 133
 SAM  A 301 ( 3.8A)
SAM  A 301 (-2.4A)
SAM  A 301 (-3.7A)
 0.32A 2b25B-1nt2A:
13.7		 2b25B-1nt2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		3 GLY A 108
GLU A 132
ASP A 176
 None
 0.39A 2b25B-1o54A:
25.6		 2b25B-1o54A:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzq EQUINATOXIN II

(Actinia equina) 		PF06369
(Anemone_cytotox) 		3 GLY A  11
GLU A  40
ASP A  10
 None
 0.67A 2b25B-1tzqA:
undetectable		 2b25B-1tzqA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 GLY A  19
GLU A 220
ASP A 256
 None
 0.70A 2b25B-1wl4A:
undetectable		 2b25B-1wl4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE

(Rattus
norvegicus) 		no annotation 3 GLY A  67
GLU A  89
ASP A 134
 SAH  A 236 (-3.4A)
SAH  A 236 (-2.9A)
NMG  A 237 ( 3.0A)
 0.36A 2b25B-1xcjA:
12.5		 2b25B-1xcjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhl SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY MEMBER
(5L265), PUTATIVE
TROPINONE
REDUCTASE-II

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		3 GLY A  72
GLU A  69
ASP A  75
 None
 0.68A 2b25B-1xhlA:
6.1		 2b25B-1xhlA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME

(Thermotoga
maritima) 		PF10396
(TrmE_N) 		3 GLY B  23
GLU B  74
ASP B  25
 None
 0.69A 2b25B-1xzqB:
undetectable		 2b25B-1xzqB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb2 HYPOTHETICAL PROTEIN
TA0852

(Thermoplasma
acidophilum) 		PF08704
(GCD14) 		3 GLY A  98
GLU A 122
ASP A 166
 None
 0.46A 2b25B-1yb2A:
15.9		 2b25B-1yb2A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avd CATECHOL-O-METHYLTRA
NSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		3 GLY A 110
GLU A 134
ASP A 185
 SAM  A 501 (-3.4A)
SAM  A 501 (-2.9A)
SAM  A 501 (-3.4A)
 0.19A 2b25B-2avdA:
15.0		 2b25B-2avdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLY A 209
GLU A 111
ASP A 189
 None
 0.42A 2b25B-2b1pA:
undetectable		 2b25B-2b1pA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		3 GLY A 111
GLU A 135
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-2.9A)
SAM  A 601 (-3.5A)
 0.12A 2b25B-2b25A:
37.0		 2b25B-2b25A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9l PROPHENOLOXIDASE
ACTIVATING FACTOR

(Holotrichia
diomphalia) 		PF00089
(Trypsin) 		3 GLY A  59
GLU A 104
ASP A  63
 None
 0.61A 2b25B-2b9lA:
undetectable		 2b25B-2b9lA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		3 GLY A 125
GLU A 181
ASP A 122
 None
None
MN  A 302 (-2.5A)
 0.65A 2b25B-2cevA:
undetectable		 2b25B-2cevA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90) 		3 GLY A 559
GLU A 556
ASP A 560
 None
 0.69A 2b25B-2cgeA:
undetectable		 2b25B-2cgeA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzm FAS-ASSOCIATED
FACTOR 1

(Homo sapiens) 		no annotation 3 GLY A  32
GLU A  33
ASP A  61
 None
 0.62A 2b25B-2dzmA:
undetectable		 2b25B-2dzmA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6s E3 UBIQUITIN-PROTEIN
LIGASE UHRF2

(Homo sapiens) 		PF00628
(PHD) 		3 GLY A  18
GLU A  12
ASP A  19
 None
 0.69A 2b25B-2e6sA:
undetectable		 2b25B-2e6sA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7u TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		3 GLY A 110
GLU A 161
ASP A 109
 None
 0.58A 2b25B-2g7uA:
undetectable		 2b25B-2g7uA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 GLY A  53
GLU A 254
ASP A 288
 None
 0.63A 2b25B-2ibuA:
undetectable		 2b25B-2ibuA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN

(Homo sapiens) 		PF01269
(Fibrillarin) 		3 GLY A 168
GLU A 192
ASP A 237
 MTA  A4001 (-3.3A)
MTA  A4001 (-2.7A)
MTA  A4001 (-4.3A)
 0.29A 2b25B-2ipxA:
14.6		 2b25B-2ipxA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mw1 LIPOCALIN-LIKE
PROTEIN

(Bacteroides
thetaiotaomicron) 		no annotation 3 GLY A  69
GLU A  54
ASP A  68
 None
 0.64A 2b25B-2mw1A:
undetectable		 2b25B-2mw1A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n4i SELECTION AND UPKEEP
OF INTRAEPITHELIAL
T-CELLS PROTEIN 1

(Mus musculus) 		PF07686
(V-set) 		3 GLY A 128
GLU A  61
ASP A 129
 None
 0.61A 2b25B-2n4iA:
undetectable		 2b25B-2n4iA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyp BETA-LACTAMASE II

(Bacillus cereus) 		PF00753
(Lactamase_B) 		3 GLY A 214
GLU A 212
ASP A 215
 None
 0.70A 2b25B-2nypA:
undetectable		 2b25B-2nypA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oo4 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2

(Homo sapiens) 		PF00066
(Notch)
PF06816
(NOD)
PF07684
(NODP) 		3 GLY A1453
GLU A1460
ASP A1454
 None
None
CA  A5001 (-3.4A)
 0.68A 2b25B-2oo4A:
undetectable		 2b25B-2oo4A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7n PATHOGENICITY ISLAND
1 EFFECTOR PROTEIN

(Chromobacterium
violaceum) 		PF06511
(IpaD) 		3 GLY A 198
GLU A 201
ASP A 194
 None
 0.55A 2b25B-2p7nA:
undetectable		 2b25B-2p7nA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLY A 124
GLU A 147
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-2.6A)
 0.63A 2b25B-2pt6A:
9.7		 2b25B-2pt6A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		3 GLY A 233
GLU A 258
ASP A 341
 UNL  A 414 (-4.0A)
None
None
 0.37A 2b25B-2py6A:
9.6		 2b25B-2py6A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 3 GLY A   2
GLU A  11
ASP A 336
 None
 0.44A 2b25B-2quaA:
undetectable		 2b25B-2quaA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		3 GLY A  86
GLU A 121
ASP A 198
 None
 0.34A 2b25B-2qy6A:
10.0		 2b25B-2qy6A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmo LMO2642 PROTEIN

(Listeria
monocytogenes) 		PF00149
(Metallophos) 		3 GLY A 106
GLU A 107
ASP A 136
 None
 0.68A 2b25B-2xmoA:
undetectable		 2b25B-2xmoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		3 GLY A 248
GLU A 379
ASP A 249
 None
 0.59A 2b25B-2yg1A:
undetectable		 2b25B-2yg1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		3 GLY A  99
GLU A 120
ASP A 165
 SAM  A 601 (-3.2A)
SAM  A 601 (-2.7A)
SAM  A 601 (-3.4A)
 0.38A 2b25B-2yvlA:
26.6		 2b25B-2yvlA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbc 83AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR ASNC

(Sulfurisphaera
tokodaii) 		PF01037
(AsnC_trans_reg) 		3 GLY A  14
GLU A  17
ASP A  11
 None
 0.68A 2b25B-2zbcA:
undetectable		 2b25B-2zbcA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLY A  84
GLU A 107
ASP A 161
 None
None
AG3  A1001 (-2.8A)
 0.59A 2b25B-2zsuA:
10.5		 2b25B-2zsuA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5q PUTATIVE SULFATASE
YIDJ

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 GLY A 116
GLU A 131
ASP A 175
 None
 0.70A 2b25B-3b5qA:
undetectable		 2b25B-3b5qA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwm CATECHOL
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		3 GLY A  66
GLU A  90
ASP A 141
 SAM  A 301 (-3.2A)
SAM  A 301 (-2.8A)
MG  A 300 (-2.4A)
 0.25A 2b25B-3bwmA:
15.3		 2b25B-3bwmA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLY A 198
GLU A 220
ASP A 276
 MTA  A 401 (-3.3A)
MTA  A 401 (-2.5A)
SPM  A 501 ( 3.2A)
 0.64A 2b25B-3c6mA:
11.6		 2b25B-3c6mA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3caw O-SUCCINYLBENZOATE
SYNTHASE

(Bdellovibrio
bacteriovorus) 		no annotation 3 GLY A 275
GLU A  97
ASP A 276
 None
 0.65A 2b25B-3cawA:
undetectable		 2b25B-3cawA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION

(Ruegeria
pomeroyi) 		no annotation 3 GLY A  37
GLU A  57
ASP A 128
 None
 0.25A 2b25B-3cvoA:
10.6		 2b25B-3cvoA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dho STREPTOGRAMIN A
ACETYLTRANSFERASE

(Enterococcus
faecium) 		PF00132
(Hexapep) 		3 GLY A  72
GLU A  44
ASP A 125
 None
 0.70A 2b25B-3dhoA:
undetectable		 2b25B-3dhoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dv9 BETA-PHOSPHOGLUCOMUT
ASE

(Bacteroides
vulgatus) 		PF13419
(HAD_2) 		3 GLY A  29
GLU A  62
ASP A  33
 MG  A 301 ( 4.6A)
MG  A 301 ( 3.1A)
None
 0.68A 2b25B-3dv9A:
2.3		 2b25B-3dv9A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdi UNCHARACTERIZED
PROTEIN

(Eubacterium
ventriosum) 		PF13189
(Cytidylate_kin2) 		3 GLY A 122
GLU A  11
ASP A 123
 None
 0.65A 2b25B-3fdiA:
undetectable		 2b25B-3fdiA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN

(Bacteroides
thetaiotaomicron) 		PF10282
(Lactonase) 		3 GLY A 284
GLU A 252
ASP A 285
 None
 0.70A 2b25B-3fgbA:
undetectable		 2b25B-3fgbA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum) 		no annotation 3 GLY A  94
GLU A 117
ASP A 163
 None
FMT  A 315 (-3.6A)
None
 0.35A 2b25B-3gjyA:
11.0		 2b25B-3gjyA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goa 3-KETOACYL-COA
THIOLASE

(Salmonella
enterica) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 GLY A  15
GLU A 208
ASP A 243
 None
 0.59A 2b25B-3goaA:
undetectable		 2b25B-3goaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE

(Ruegeria
pomeroyi) 		PF12692
(Methyltransf_17) 		3 GLY A  47
GLU A  70
ASP A 112
 SAM  A 200 (-3.3A)
SAM  A 200 (-2.7A)
SAM  A 200 (-3.7A)
 0.58A 2b25B-3ihtA:
9.8		 2b25B-3ihtA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipw HYDROLASE TATD
FAMILY PROTEIN

(Entamoeba
histolytica) 		PF01026
(TatD_DNase) 		3 GLY A 180
GLU A 184
ASP A 179
 None
 0.65A 2b25B-3ipwA:
undetectable		 2b25B-3ipwA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		3 GLY A 101
GLU A 125
ASP A 169
 SAH  A 301 (-3.1A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.6A)
 0.39A 2b25B-3lgaA:
25.2		 2b25B-3lgaA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lim FRAGACEATOXIN C

(Actinia
fragacea) 		PF06369
(Anemone_cytotox) 		3 GLY A  11
GLU A  40
ASP A  10
 None
 0.62A 2b25B-3limA:
undetectable		 2b25B-3limA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE

(Ehrlichia
chaffeensis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 GLY A 350
GLU A 352
ASP A 406
 None
 0.56A 2b25B-3lp8A:
2.8		 2b25B-3lp8A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m65 ATP-DEPENDENT
PROTEASE LA 1

(Bacillus
subtilis) 		PF02190
(LON_substr_bdg) 		3 GLY A  62
GLU A 103
ASP A  64
 None
 0.57A 2b25B-3m65A:
undetectable		 2b25B-3m65A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca PROTEIN DOM34

(Schizosaccharomyces
pombe) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		3 GLY B 353
GLU B 274
ASP B 357
 None
 0.65A 2b25B-3mcaB:
undetectable		 2b25B-3mcaB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on2 PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13305
(WHG) 		3 GLY A  29
GLU A 106
ASP A  31
 None
 0.59A 2b25B-3on2A:
undetectable		 2b25B-3on2A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orh GUANIDINOACETATE
N-METHYLTRANSFERASE

(Homo sapiens) 		no annotation 3 GLY A  68
GLU A  90
ASP A 135
 SAH  A4000 (-3.4A)
SAH  A4000 (-2.7A)
SAH  A4000 (-3.7A)
 0.39A 2b25B-3orhA:
12.0		 2b25B-3orhA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pge SUMO-MODIFIED
PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF02747
(PCNA_C)
PF11976
(Rad60-SLD) 		3 GLY A  69
GLU A 101
ASP A  68
 None
 0.67A 2b25B-3pgeA:
undetectable		 2b25B-3pgeA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		3 GLY A  66
GLU A 101
ASP A 178
 SAM  A 670 (-3.5A)
SAM  A 670 (-2.6A)
SAM  A 670 (-3.4A)
 0.32A 2b25B-3ps9A:
9.6		 2b25B-3ps9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		3 GLY A  66
GLU A 101
ASP A 178
 None
 0.37A 2b25B-3pvcA:
10.0		 2b25B-3pvcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		3 GLY A1313
GLU A1349
ASP A1317
 None
 0.65A 2b25B-3pvlA:
undetectable		 2b25B-3pvlA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLY A 101
GLU A 124
ASP A 173
 DSH  A 303 (-3.4A)
DSH  A 303 (-2.6A)
DSH  A 303 (-3.0A)
 0.61A 2b25B-3rw9A:
9.7		 2b25B-3rw9A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfw PUTATIVE
O-METHYLTRANSFERASE

(Klebsiella
pneumoniae) 		PF01596
(Methyltransf_3) 		3 GLY A  69
GLU A  93
ASP A 141
 None
 0.26A 2b25B-3tfwA:
15.3		 2b25B-3tfwA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 GLY A 567
GLU A 570
ASP A 566
 None
 0.64A 2b25B-3ulzA:
undetectable		 2b25B-3ulzA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpj TSE1-SPECIFIC
IMMUNITY PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 3 GLY E  84
GLU E 105
ASP E  83
 None
 0.69A 2b25B-3vpjE:
undetectable		 2b25B-3vpjE:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		3 GLY A 104
GLU A 133
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.8A)
 0.30A 2b25B-3vywA:
9.7		 2b25B-3vywA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arp PESTICIN

(Yersinia pestis) 		PF16754
(Pesticin) 		3 GLY A 104
GLU A  66
ASP A 103
 None
 0.41A 2b25B-4arpA:
undetectable		 2b25B-4arpA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Pyrococcus
furiosus) 		PF01269
(Fibrillarin) 		3 GLY E  81
GLU E 105
ASP E 150
 None
None
C  X   5 ( 3.2A)
 0.59A 2b25B-4by9E:
12.0		 2b25B-4by9E:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 GLY A  18
GLU A 221
ASP A 255
 None
 0.69A 2b25B-4c2kA:
undetectable		 2b25B-4c2kA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 GLY A  20
GLU A 222
ASP A 256
 None
 0.69A 2b25B-4dd5A:
undetectable		 2b25B-4dd5A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		3 GLY A  85
GLU A 109
ASP A 154
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.6A)
 0.26A 2b25B-4df3A:
14.1		 2b25B-4df3A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Campylobacter
jejuni) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		3 GLY A 375
GLU A 373
ASP A 377
 None
 0.65A 2b25B-4ehiA:
2.1		 2b25B-4ehiA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emy AMINOTRANSFERASE
CLASS I AND II

(Anaerococcus
prevotii) 		PF00155
(Aminotran_1_2) 		3 GLY A 231
GLU A 226
ASP A 232
 None
 0.57A 2b25B-4emyA:
2.3		 2b25B-4emyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcx ISOCITRATE
DEHYDROGENASE [NADP]

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		3 GLY A  48
GLU A  50
ASP A  17
 None
 0.61A 2b25B-4hcxA:
undetectable		 2b25B-4hcxA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 GLY A 966
GLU A 852
ASP A 967
 None
 0.70A 2b25B-4lglA:
2.5		 2b25B-4lglA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmh HEPARINASE III
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		3 GLY A 641
GLU A 661
ASP A 637
 None
 0.56A 2b25B-4mmhA:
undetectable		 2b25B-4mmhA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo2 UDP-GALACTOPYRANOSE
MUTASE

(Campylobacter
jejuni) 		no annotation 3 GLY B 149
GLU B 152
ASP B 270
 None
 0.63A 2b25B-4mo2B:
2.8		 2b25B-4mo2B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		3 GLY A 109
GLU A 133
ASP A 184
 2F6  A 301 (-3.6A)
2F6  A 301 (-2.7A)
None
 0.19A 2b25B-4p58A:
15.5		 2b25B-4p58A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN

(Anaplasma
phagocytophilum) 		PF01596
(Methyltransf_3) 		3 GLY A  64
GLU A  88
ASP A 136
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.6A)
MN  A 303 ( 2.7A)
 0.15A 2b25B-4pclA:
15.0		 2b25B-4pclA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLY A 124
GLU A 147
ASP A 196
 MTA  A 401 (-3.5A)
MTA  A 401 (-2.7A)
4ZY  A 501 ( 3.6A)
 0.67A 2b25B-4uoeA:
9.6		 2b25B-4uoeA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w78 HYDRATASE CHSH1

(Mycobacterium
tuberculosis) 		PF13452
(MaoC_dehydrat_N) 		3 GLY A 128
GLU A 126
ASP A 129
 None
 0.57A 2b25B-4w78A:
undetectable		 2b25B-4w78A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymg PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE

(Podospora
anserina) 		PF01596
(Methyltransf_3) 		3 GLY A  73
GLU A  98
ASP A 144
 SAM  A1001 (-3.3A)
SAM  A1001 (-2.7A)
SAM  A1001 (-3.6A)
 0.22A 2b25B-4ymgA:
14.3		 2b25B-4ymgA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		3 GLY A 169
GLU A  71
ASP A 149
 None
MG  A 403 (-3.4A)
None
 0.44A 2b25B-5awmA:
undetectable		 2b25B-5awmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 GLY A  17
GLU A 223
ASP A 260
 None
 0.67A 2b25B-5bz4A:
undetectable		 2b25B-5bz4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		3 GLY A 111
GLU A 135
ASP A 181
 SAH  A 301 (-3.2A)
SAH  A 301 (-2.2A)
SAH  A 301 (-2.4A)
 0.33A 2b25B-5ccxA:
24.2		 2b25B-5ccxA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		3 GLY B 118
GLU B 139
ASP B 203
 SAM  B 401 (-3.4A)
SAM  B 401 (-2.9A)
SAM  B 401 (-3.3A)
 0.35A 2b25B-5ergB:
20.6		 2b25B-5ergB:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01269
(Fibrillarin) 		3 GLY E  84
GLU E 108
ASP E 153
 SAH  E 301 (-3.8A)
SAH  E 301 (-3.0A)
SAH  E 301 (-3.7A)
 0.42A 2b25B-5ginE:
14.5		 2b25B-5ginE:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxd AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Dinoroseobacter
shibae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 GLY A 534
GLU A 366
ASP A 530
 None
 0.67A 2b25B-5gxdA:
undetectable		 2b25B-5gxdA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 3 GLY A 284
GLU A 392
ASP A 266
 None
None
CA  A 614 (-3.0A)
 0.68A 2b25B-5k8gA:
undetectable		 2b25B-5k8gA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE

(Arabidopsis
thaliana) 		PF03254
(XG_FTase) 		3 GLY A 312
GLU A 283
ASP A 315
 None
 0.60A 2b25B-5kx6A:
undetectable		 2b25B-5kx6A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		3 GLY A1157
GLU A1012
ASP A1158
 None
 0.68A 2b25B-5lsuA:
undetectable		 2b25B-5lsuA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		3 GLY A 945
GLU A1001
ASP A 944
 None
 0.63A 2b25B-5mqsA:
undetectable		 2b25B-5mqsA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5d METHYLTRANSFERASE

(Streptomyces
regensis) 		PF01596
(Methyltransf_3) 		3 GLY A  65
GLU A  89
ASP A 139
 SAM  A 306 (-3.2A)
SAM  A 306 (-2.4A)
SAM  A 306 (-2.3A)
 0.12A 2b25B-5n5dA:
15.6		 2b25B-5n5dA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		3 GLY A  39
GLU A  37
ASP A  40
 None
 0.69A 2b25B-5tzbA:
undetectable		 2b25B-5tzbA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfk UNCHARACTERIZED
PROTEIN

(Sulfolobus
solfataricus) 		no annotation 3 GLY A   9
GLU A   7
ASP A  12
 None
 0.63A 2b25B-5vfkA:
undetectable		 2b25B-5vfkA:
undetectable