SIMILAR PATTERNS OF AMINO ACIDS FOR 2AZY_A_CHDA237_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ae7 PHOSPHOLIPASE A2

(Notechis
scutatus)
PF00068
(Phospholip_A2_1)
6 ILE A   9
TYR A  25
GLY A  30
LEU A  41
PHE A 106
TYR A 111
None
0.58A 2azyA-1ae7A:
16.8
2azyA-1ae7A:
48.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg5 FUSION PROTEIN OF
ALPHA-NA,K-ATPASE
WITH GLUTATHIONE
S-TRANSFERASE


(Rattus
norvegicus)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 ARG A  73
ILE A  72
HIS A  79
MET A  81
TYR A  23
None
1.19A 2azyA-1bg5A:
undetectable
2azyA-1bg5A:
17.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpq PHOSPHOLIPASE A2

(Bos taurus)
PF00068
(Phospholip_A2_1)
6 ILE A   9
ILE A  13
TYR A  25
GLY A  30
LEU A  41
PHE A 106
None
None
None
CA  A 124 (-4.2A)
None
None
0.41A 2azyA-1bpqA:
19.9
2azyA-1bpqA:
83.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpq PHOSPHOLIPASE A2

(Bos taurus)
PF00068
(Phospholip_A2_1)
6 ILE A   9
ILE A  13
TYR A  25
GLY A  30
LEU A  41
TYR A 111
None
None
None
CA  A 124 (-4.2A)
None
None
0.63A 2azyA-1bpqA:
19.9
2azyA-1bpqA:
83.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bun BETA2-BUNGAROTOXIN

(Bungarus
multicinctus)
PF00068
(Phospholip_A2_1)
5 ILE A   9
TYR A  25
GLY A  30
LEU A  41
PHE A 101
None
None
NA  A 121 (-4.4A)
NA  A 122 (-4.5A)
None
0.55A 2azyA-1bunA:
17.4
2azyA-1bunA:
45.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bun BETA2-BUNGAROTOXIN

(Bungarus
multicinctus)
PF00068
(Phospholip_A2_1)
5 ILE A   9
TYR A  25
GLY A  30
LEU A  41
TYR A 106
None
None
NA  A 121 (-4.4A)
NA  A 122 (-4.5A)
None
0.58A 2azyA-1bunA:
17.4
2azyA-1bunA:
45.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dpy PHOSPHOLIPASE A2

(Bungarus
caeruleus)
PF00068
(Phospholip_A2_1)
6 ILE A   9
TYR A  25
GLY A  30
LEU A  41
PHE A 101
TYR A 106
None
None
NA  A 150 (-4.5A)
None
None
None
0.58A 2azyA-1dpyA:
17.4
2azyA-1dpyA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g0z PHOSPHOLIPASE A2

(Bungarus
caeruleus)
PF00068
(Phospholip_A2_1)
6 ILE A   9
TYR A  25
GLY A  30
LEU A  41
PHE A 101
TYR A 106
None
0.59A 2azyA-1g0zA:
16.9
2azyA-1g0zA:
50.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6g PROTEIN KINASE RAD53

(Saccharomyces
cerevisiae)
PF00498
(FHA)
5 ILE A 147
ASP A  47
GLY A  29
LEU A  93
PHE A 151
None
1.18A 2azyA-1g6gA:
undetectable
2azyA-1g6gA:
15.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gp7 PHOSPHOLIPASE A2

(Ophiophagus
hannah)
PF00068
(Phospholip_A2_1)
5 ILE A   9
TYR A  25
GLY A  30
LEU A  41
PHE A 106
None
None
CA  A1125 (-4.5A)
None
None
0.47A 2azyA-1gp7A:
20.3
2azyA-1gp7A:
45.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gp7 PHOSPHOLIPASE A2

(Ophiophagus
hannah)
PF00068
(Phospholip_A2_1)
5 ILE A   9
TYR A  25
GLY A  30
LEU A  41
TYR A 111
None
None
CA  A1125 (-4.5A)
None
None
0.73A 2azyA-1gp7A:
20.3
2azyA-1gp7A:
45.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkx CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN


(Mus musculus)
PF08332
(CaMKII_AD)
5 ARG A 346
ILE A 350
ILE A 429
HIS A 420
MET A 422
DTT  A1475 ( 3.7A)
None
None
None
None
1.20A 2azyA-1hkxA:
undetectable
2azyA-1hkxA:
17.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m8t PHOSPHOLIPASE A2

(Ophiophagus
hannah)
PF00068
(Phospholip_A2_1)
6 ILE A   9
ILE A  13
TYR A  25
GLY A  30
LEU A  41
PHE A 106
None
None
None
CA  A1001 (-4.3A)
None
None
0.41A 2azyA-1m8tA:
19.6
2azyA-1m8tA:
58.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m8t PHOSPHOLIPASE A2

(Ophiophagus
hannah)
PF00068
(Phospholip_A2_1)
5 ILE A  13
TYR A  25
GLY A  30
LEU A  41
TYR A 111
None
None
CA  A1001 (-4.3A)
None
None
0.74A 2azyA-1m8tA:
19.6
2azyA-1m8tA:
58.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh2 PHOSPHOLIPASE A2

(Naja
sagittifera)
PF00068
(Phospholip_A2_1)
5 ILE A   9
TYR A  25
GLY A  30
LEU A  41
PHE A 101
None
0.42A 2azyA-1mh2A:
19.5
2azyA-1mh2A:
46.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh2 PHOSPHOLIPASE A2

(Naja
sagittifera)
PF00068
(Phospholip_A2_1)
5 ILE A   9
TYR A  25
GLY A  30
LEU A  41
TYR A 106
None
0.68A 2azyA-1mh2A:
19.5
2azyA-1mh2A:
46.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh8 PHOSPHOLIPASE A2

(Naja
sagittifera)
PF00068
(Phospholip_A2_1)
5 ILE A   9
TYR A  25
GLY A  30
LEU A  41
PHE A 101
None
0.28A 2azyA-1mh8A:
19.2
2azyA-1mh8A:
49.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh8 PHOSPHOLIPASE A2

(Naja
sagittifera)
PF00068
(Phospholip_A2_1)
5 ILE A   9
TYR A  25
GLY A  30
LEU A  41
TYR A 106
None
0.59A 2azyA-1mh8A:
19.2
2azyA-1mh8A:
49.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ozy PHOSPHOLIPASE A2

(Micropechis
ikaheca)
PF00068
(Phospholip_A2_1)
6 ILE A   9
ILE A  13
TYR A  25
GLY A  30
LEU A  41
PHE A 106
None
0.78A 2azyA-1ozyA:
16.5
2azyA-1ozyA:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ozy PHOSPHOLIPASE A2

(Micropechis
ikaheca)
PF00068
(Phospholip_A2_1)
6 ILE A   9
ILE A  13
TYR A  25
GLY A  30
LEU A  41
TYR A 111
None
0.94A 2azyA-1ozyA:
16.5
2azyA-1ozyA:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p7o PHOSPHOLIPASE A2

(Micropechis
ikaheca)
PF00068
(Phospholip_A2_1)
5 ARG A   6
ILE A   9
TYR A  25
LEU A  41
PHE A 106
None
1.21A 2azyA-1p7oA:
18.9
2azyA-1p7oA:
60.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p7o PHOSPHOLIPASE A2

(Micropechis
ikaheca)
PF00068
(Phospholip_A2_1)
6 ILE A   9
ILE A  13
TYR A  25
GLY A  30
LEU A  41
PHE A 106
None
0.49A 2azyA-1p7oA:
18.9
2azyA-1p7oA:
60.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p7o PHOSPHOLIPASE A2

(Micropechis
ikaheca)
PF00068
(Phospholip_A2_1)
6 ILE A   9
ILE A  13
TYR A  25
GLY A  30
LEU A  41
TYR A 111
None
0.70A 2azyA-1p7oA:
18.9
2azyA-1p7oA:
60.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1po8 PHOSPHOLIPASE A2

(Bungarus
caeruleus)
PF00068
(Phospholip_A2_1)
5 ILE A   9
TYR A  25
GLY A  30
LEU A  41
PHE A 101
None
None
SHV  A 122 ( 3.7A)
None
None
0.32A 2azyA-1po8A:
17.7
2azyA-1po8A:
53.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1po8 PHOSPHOLIPASE A2

(Bungarus
caeruleus)
PF00068
(Phospholip_A2_1)
5 ILE A   9
TYR A  25
GLY A  30
LEU A  41
TYR A 106
None
None
SHV  A 122 ( 3.7A)
None
None
0.58A 2azyA-1po8A:
17.7
2azyA-1po8A:
53.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ppy ASPARTATE
1-DECARBOXYLASE
PRECURSOR


(Escherichia
coli)
PF02261
(Asp_decarbox)
5 ILE A  69
ILE A  87
MET A 114
GLY A  65
LEU A  33
None
1.13A 2azyA-1ppyA:
undetectable
2azyA-1ppyA:
23.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1psh PHOSPHOLIPASE A2

(Naja naja)
PF00068
(Phospholip_A2_1)
6 ILE A   9
TYR A  24
GLY A  29
LEU A  40
PHE A 100
TYR A 105
None
None
CA  A 120 (-4.4A)
None
None
None
0.65A 2azyA-1pshA:
19.3
2azyA-1pshA:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pwo PHOSPHOLIPASE A2

(Micropechis
ikaheca)
PF00068
(Phospholip_A2_1)
6 ILE A   9
ILE A  13
TYR A  25
GLY A  30
LEU A  41
PHE A 106
None
0.38A 2azyA-1pwoA:
18.5
2azyA-1pwoA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pwo PHOSPHOLIPASE A2

(Micropechis
ikaheca)
PF00068
(Phospholip_A2_1)
6 ILE A   9
ILE A  13
TYR A  25
GLY A  30
LEU A  41
TYR A 111
None
0.72A 2azyA-1pwoA:
18.5
2azyA-1pwoA:
56.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1


(Canis lupus)
PF00151
(Lipase)
PF01477
(PLAT)
5 ILE A 344
ILE A 420
GLY A 348
LEU A 444
PHE A 400
None
1.22A 2azyA-1rp1A:
undetectable
2azyA-1rp1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmk PURINE NUCLEOSIDE
PHOSPHORYLASE


(Thermotoga
maritima)
PF01048
(PNP_UDP_1)
5 ILE A 191
ILE A 115
GLY A 182
PHE A 194
TYR A 177
None
1.15A 2azyA-1vmkA:
undetectable
2azyA-1vmkA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvs PROTEIN APAG

(Vibrio cholerae)
PF04379
(DUF525)
5 ILE A 114
ILE A  10
GLY A  65
LEU A  46
TYR A  81
None
1.19A 2azyA-1xvsA:
undetectable
2azyA-1xvsA:
17.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y75 PHOSPHOLIPASE A2
ISOFORM 5


(Naja
sagittifera)
PF00068
(Phospholip_A2_1)
5 ILE A   9
TYR A  25
GLY A  30
LEU A  41
PHE A 101
None
None
NAG  A 301 (-4.0A)
None
None
0.41A 2azyA-1y75A:
18.6
2azyA-1y75A:
51.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y75 PHOSPHOLIPASE A2
ISOFORM 6


(Naja
sagittifera)
PF00068
(Phospholip_A2_1)
6 ILE B   9
TYR B  25
GLY B  30
LEU B  41
PHE B 101
TYR B 106
None
0.60A 2azyA-1y75B:
18.7
2azyA-1y75B:
47.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bud MALES-ABSENT ON THE
FIRST PROTEIN


(Drosophila
melanogaster)
PF11717
(Tudor-knot)
5 ARG A 387
ILE A 385
ILE A 432
GLY A 418
TYR A 413
None
1.23A 2azyA-2budA:
undetectable
2azyA-2budA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs7 PNEUMOCOCCAL
HISTIDINE TRIAD A
PROTEIN


(Streptococcus
pneumoniae)
PF04270
(Strep_his_triad)
5 ILE A  16
HIS A  33
GLY A  21
LEU A  40
TYR A   3
None
ZN  A 201 (-3.2A)
None
None
None
1.23A 2azyA-2cs7A:
undetectable
2azyA-2cs7A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gvi CONSERVED
HYPOTHETICAL PROTEIN


(Thermoplasma
acidophilum)
PF02663
(FmdE)
5 ARG A 104
ILE A 151
ILE A 143
MET A 108
TYR A  22
ACY  A 407 ( 4.3A)
None
None
None
UNL  A 400 (-4.8A)
0.96A 2azyA-2gviA:
undetectable
2azyA-2gviA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzq PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN


(Plasmodium
vivax)
PF01161
(PBP)
5 ILE A 135
ILE A 181
ASP A  90
LEU A  10
PHE A 184
None
1.20A 2azyA-2gzqA:
undetectable
2azyA-2gzqA:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h4c PHOSPHOLIPASE A2-II

(Daboia
siamensis)
PF00068
(Phospholip_A2_1)
5 ILE B   9
TYR B  25
GLY B  30
PHE B 106
TYR B 113
None
0.60A 2azyA-2h4cB:
14.9
2azyA-2h4cB:
36.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana)
PF00291
(PALP)
5 ILE A 165
ILE A 173
GLY A 184
LEU A 202
PHE A 176
None
None
PLP  A 400 ( 4.1A)
None
None
1.16A 2azyA-2isqA:
undetectable
2azyA-2isqA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7p FILAMIN-A

(Homo sapiens)
PF00630
(Filamin)
5 ARG A1845
ILE A1851
ILE A1795
GLY A1802
PHE A1797
None
1.23A 2azyA-2k7pA:
undetectable
2azyA-2k7pA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nw0 PLYB

(unidentified
phage)
PF01183
(Glyco_hydro_25)
5 ARG A 174
ILE A   4
ILE A  27
GLY A 177
PHE A 184
None
1.21A 2azyA-2nw0A:
undetectable
2azyA-2nw0A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW


(Escherichia
virus T4)
PF00271
(Helicase_C)
PF04851
(ResIII)
5 ILE A  68
ILE A   3
HIS A   6
GLY A  63
LEU A  54
None
1.20A 2azyA-2ocaA:
undetectable
2azyA-2ocaA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW


(Escherichia
virus T4)
PF00271
(Helicase_C)
PF04851
(ResIII)
5 ILE A  68
ILE A   3
HIS A   6
GLY A 274
LEU A  54
None
0.99A 2azyA-2ocaA:
undetectable
2azyA-2ocaA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes)
PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
5 ILE A 103
ILE A 125
GLY A  93
LEU A 110
PHE A 105
None
1.21A 2azyA-2omvA:
undetectable
2azyA-2omvA:
12.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2osn PHOSPHOLIPASE A2
ISOFORM 3


(Bungarus
caeruleus)
PF00068
(Phospholip_A2_1)
6 ILE A  11
TYR A  25
GLY A  30
LEU A  41
PHE A 101
TYR A 106
None
0.56A 2azyA-2osnA:
16.8
2azyA-2osnA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1


(Arabidopsis
thaliana)
PF00724
(Oxidored_FMN)
5 ILE A 102
GLY A 233
LEU A 322
PHE A  59
TYR A  16
None
1.04A 2azyA-2q3rA:
undetectable
2azyA-2q3rA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1


(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
5 ILE A 429
MET A 366
ASP A 371
GLY A 377
TYR A 245
None
1.20A 2azyA-2yd0A:
undetectable
2azyA-2yd0A:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE


(Thermotoga
maritima)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
5 ARG A 174
ILE A 173
HIS A 177
GLY A 205
LEU A 161
None
None
PLP  A 401 ( 4.8A)
None
None
1.14A 2azyA-2yxxA:
undetectable
2azyA-2yxxA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 ASP H  62
GLY H  65
LEU H  80
PHE H  69
TYR H  90
None
GOL  H 214 ( 3.7A)
None
None
None
1.14A 2azyA-2zpkH:
undetectable
2azyA-2zpkH:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1


(Aeropyrum
pernix)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
5 ARG A 311
ILE A 309
ILE A 308
PHE A 283
TYR A 257
None
1.19A 2azyA-3a31A:
undetectable
2azyA-3a31A:
11.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elo PHOSPHOLIPASE A2

(Homo sapiens)
PF00068
(Phospholip_A2_1)
5 ILE A   9
ILE A  13
TYR A  25
LEU A  41
PHE A 106
None
0.72A 2azyA-3eloA:
16.1
2azyA-3eloA:
81.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elo PHOSPHOLIPASE A2

(Homo sapiens)
PF00068
(Phospholip_A2_1)
5 ILE A   9
TYR A  25
GLY A  30
LEU A  41
TYR A 111
None
1.14A 2azyA-3eloA:
16.1
2azyA-3eloA:
81.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elo PHOSPHOLIPASE A2

(Homo sapiens)
PF00068
(Phospholip_A2_1)
5 ILE A  13
TYR A  25
GLY A  30
LEU A  41
PHE A 106
None
0.64A 2azyA-3eloA:
16.1
2azyA-3eloA:
81.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgo 12-OXOPHYTODIENOATE
REDUCTASE 3


(Solanum
lycopersicum)
PF00724
(Oxidored_FMN)
5 ARG A 233
ASP A 232
GLY A 235
PHE A  59
TYR A  16
None
1.14A 2azyA-3hgoA:
undetectable
2azyA-3hgoA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgo 12-OXOPHYTODIENOATE
REDUCTASE 3


(Solanum
lycopersicum)
PF00724
(Oxidored_FMN)
5 ARG A 233
GLY A 235
LEU A 338
PHE A  59
TYR A  16
None
0.94A 2azyA-3hgoA:
undetectable
2azyA-3hgoA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrv PROTEIN K7

(Vaccinia virus)
PF06227
(Poxvirus)
5 ILE A  26
ILE A  20
TYR A  33
LEU A  57
TYR A  54
None
1.05A 2azyA-3jrvA:
undetectable
2azyA-3jrvA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE


(Babesia bovis)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 ILE A 120
ASP A  10
TYR A   5
GLY A   7
LEU A 104
None
None
None
None
NAP  A 512 (-4.8A)
1.20A 2azyA-3kjrA:
undetectable
2azyA-3kjrA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp RNA-DIRECTED RNA
POLYMERASE BETA
CHAIN


(Escherichia
virus Qbeta)
no annotation 5 ILE G 139
ILE G 135
TYR G 327
GLY G 235
LEU G 299
None
1.04A 2azyA-3mmpG:
undetectable
2azyA-3mmpG:
12.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p2p PHOSPHOLIPASE A2

(Sus scrofa)
PF00068
(Phospholip_A2_1)
6 ILE A   9
ILE A  13
HIS A  17
GLY A  30
LEU A  41
PHE A 106
None
None
None
CA  A 125 (-4.3A)
None
None
0.83A 2azyA-3p2pA:
19.9
2azyA-3p2pA:
93.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p2p PHOSPHOLIPASE A2

(Sus scrofa)
PF00068
(Phospholip_A2_1)
7 ILE A   9
ILE A  13
TYR A  25
GLY A  30
LEU A  41
PHE A 106
TYR A 111
None
None
None
CA  A 125 (-4.3A)
None
None
None
0.38A 2azyA-3p2pA:
19.9
2azyA-3p2pA:
93.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN


(Streptococcus
pneumoniae)
PF06824
(Glyco_hydro_125)
5 ARG A  82
ILE A  85
HIS A  73
LEU A  37
TYR A  33
None
None
EDO  A 435 (-4.5A)
None
None
1.18A 2azyA-3qpfA:
undetectable
2azyA-3qpfA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvq PHOSPHODIESTERASE
OLEI02445


(Oleispira
antarctica)
PF03009
(GDPD)
5 ILE A  96
ILE A  54
TYR A  71
GLY A  68
PHE A  55
None
None
None
CL  A 257 (-3.9A)
None
1.23A 2azyA-3qvqA:
undetectable
2azyA-3qvqA:
18.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9m PHOSPHOLIPASE A2
ISOZYME PA-11


(Pseudechis
australis)
PF00068
(Phospholip_A2_1)
6 ILE A   9
TYR A  25
GLY A  30
LEU A  41
PHE A  99
TYR A 104
None
None
EDO  A 201 (-3.5A)
None
None
None
0.60A 2azyA-3v9mA:
17.9
2azyA-3v9mA:
55.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vbz PHOSPHOLIPASE A2
HOMOLOG, TAIPOXIN
BETA CHAIN


(Oxyuranus
scutellatus)
PF00068
(Phospholip_A2_1)
5 ILE A   9
ILE A  13
TYR A  25
GLY A  30
LEU A  41
None
0.57A 2azyA-3vbzA:
17.7
2azyA-3vbzA:
45.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vbz PHOSPHOLIPASE A2
HOMOLOG, TAIPOXIN
BETA CHAIN


(Oxyuranus
scutellatus)
PF00068
(Phospholip_A2_1)
5 ILE A  13
TYR A  25
GLY A  30
LEU A  41
TYR A 104
None
0.93A 2azyA-3vbzA:
17.7
2azyA-3vbzA:
45.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9u PUTATIVE LIPASE

(Proteus
mirabilis)
PF00561
(Abhydrolase_1)
5 ARG A  86
ILE A  76
HIS A  78
GLY A  54
PHE A  75
None
1.23A 2azyA-3w9uA:
undetectable
2azyA-3w9uA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zcb ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VBHT


(Bartonella
schoenbuchensis)
PF02661
(Fic)
5 ARG A 191
ILE A 190
ILE A 150
TYR A 127
TYR A 128
None
1.15A 2azyA-3zcbA:
undetectable
2azyA-3zcbA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azd ASPARTATE
1-DECARBOXYLASE


(Escherichia
coli)
PF02261
(Asp_decarbox)
5 ILE A  69
ILE A  87
MET A 114
GLY A  65
LEU A  33
None
1.14A 2azyA-4azdA:
undetectable
2azyA-4azdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0e NOT1

(Chaetomium
thermophilum)
PF04054
(Not1)
5 ILE A1838
MET A1784
ASP A1785
GLY A1791
LEU A1819
None
1.22A 2azyA-4c0eA:
undetectable
2azyA-4c0eA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c76 FMN REDUCTASE
(NADPH)


(Pseudomonas
putida)
PF03358
(FMN_red)
5 ILE A  73
HIS A  96
TYR A  90
GLY A  82
LEU A 133
None
1.02A 2azyA-4c76A:
undetectable
2azyA-4c76A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnh UNCHARACTERIZED
PROTEIN


(Sinorhizobium
meliloti)
PF06187
(DUF993)
5 ILE A 154
ILE A 144
GLY A 229
LEU A 180
TYR A 176
None
1.10A 2azyA-4dnhA:
undetectable
2azyA-4dnhA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efh ACTIN-1

(Acanthamoeba
castellanii)
PF00022
(Actin)
5 ILE A 309
HIS A 275
GLY A 156
LEU A 185
PHE A 306
None
None
ADP  A 403 (-3.3A)
None
ADP  A 403 (-3.7A)
1.20A 2azyA-4efhA:
undetectable
2azyA-4efhA:
15.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h0s BASIC PHOSPHOLIPASE
A2 HOMOLOG CTS-R6


(Trimeresurus
stejnegeri)
PF00068
(Phospholip_A2_1)
5 ARG A   6
ILE A   9
TYR A  25
GLY A  30
PHE A 106
None
0.88A 2azyA-4h0sA:
14.6
2azyA-4h0sA:
34.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE


(Vitis vinifera)
PF00701
(DHDPS)
5 ILE A 166
ILE A 171
GLY A 103
LEU A 148
PHE A 144
None
1.21A 2azyA-4hnnA:
undetectable
2azyA-4hnnA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j34 KYNURENINE
3-MONOOXYGENASE


(Saccharomyces
cerevisiae)
PF01494
(FAD_binding_3)
5 ILE A 232
TYR A 374
GLY A 324
LEU A 193
PHE A 246
None
0.99A 2azyA-4j34A:
undetectable
2azyA-4j34A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE


(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
5 ILE A 470
MET A 406
ASP A 411
GLY A 417
TYR A 285
None
1.20A 2azyA-4kxbA:
undetectable
2azyA-4kxbA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgc BILE ACID-COENZYME A
LIGASE


([Clostridium]
scindens)
PF00501
(AMP-binding)
5 ILE A  99
ILE A 100
GLY A 235
LEU A  36
PHE A 103
None
1.15A 2azyA-4lgcA:
undetectable
2azyA-4lgcA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT


(Francisella
tularensis)
PF02222
(ATP-grasp)
5 ILE A 230
HIS A 108
TYR A 240
GLY A 194
LEU A 244
None
1.20A 2azyA-4ma5A:
undetectable
2azyA-4ma5A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkb PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE ZYG-1


(Caenorhabditis
elegans)
no annotation 5 ILE A 506
MET A 501
ASP A 502
GLY A 462
TYR A 532
None
1.16A 2azyA-4nkbA:
undetectable
2azyA-4nkbA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A


(Staphylococcus
aureus)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
5 ARG B 479
ILE B 478
ILE B 461
GLY B 488
PHE B 523
None
1.18A 2azyA-4plbB:
undetectable
2azyA-4plbB:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv1 CYTOCHROME B6-F
COMPLEX IRON-SULFUR
SUBUNIT


(Mastigocladus
laminosus)
PF00355
(Rieske)
PF08802
(CytB6-F_Fe-S)
5 ILE D  91
ILE D 160
GLY D  76
LEU D  70
PHE D  69
None
1.16A 2azyA-4pv1D:
undetectable
2azyA-4pv1D:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus)
PF00710
(Asparaginase)
5 ILE A 227
ILE A 205
MET A 259
GLY A 283
LEU A 244
None
0.97A 2azyA-4q0mA:
undetectable
2azyA-4q0mA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qku HYDROLASE

(Burkholderia
cenocepacia)
PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N)
5 ILE A 312
HIS A 336
MET A 337
GLY A 362
LEU A 215
None
1.06A 2azyA-4qkuA:
undetectable
2azyA-4qkuA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE


(Francisella
tularensis)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 ILE A 328
ILE A 284
GLY A 146
LEU A 278
PHE A 338
None
1.19A 2azyA-4wojA:
undetectable
2azyA-4wojA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME


(Schistosoma
japonicum)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 ILE A  71
ILE A  74
GLY A  11
LEU A   4
TYR A  27
None
BYR  A  73 ( 4.3A)
None
BYR  A  57 ( 4.4A)
None
1.09A 2azyA-4wr4A:
undetectable
2azyA-4wr4A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2


(Saccharomyces
cerevisiae)
no annotation 5 ARG G 524
ILE G 520
ILE G 519
MET G 529
GLY G 551
None
1.21A 2azyA-4xr7G:
undetectable
2azyA-4xr7G:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE


(Artemisia annua)
PF00724
(Oxidored_FMN)
5 ARG A 228
GLY A 230
LEU A 335
PHE A  54
TYR A  11
None
1.15A 2azyA-5dxxA:
undetectable
2azyA-5dxxA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1


(Fervidobacterium
islandicum)
PF02074
(Peptidase_M32)
5 ILE A 248
ILE A 244
TYR A 304
GLY A 302
LEU A 322
None
1.18A 2azyA-5e3xA:
undetectable
2azyA-5e3xA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA


(Homo sapiens)
PF08332
(CaMKII_AD)
5 ARG A 346
ILE A 350
ILE A 429
HIS A 420
MET A 422
None
1.20A 2azyA-5ig3A:
undetectable
2azyA-5ig3A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
5 ILE A 245
ILE A 248
GLY A 208
LEU A 275
TYR A 272
None
1.21A 2azyA-5j0aA:
undetectable
2azyA-5j0aA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8q CYSTEINE DESULFURASE
SUFS


(Bacillus
subtilis)
PF00266
(Aminotran_5)
5 ARG A  75
ILE A  86
ILE A  87
GLY A  69
PHE A  88
None
1.07A 2azyA-5j8qA:
undetectable
2azyA-5j8qA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxx ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Moraxella
catarrhalis)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 ILE A  81
ILE A  63
HIS A  94
GLY A 125
LEU A 112
None
1.15A 2azyA-5jxxA:
undetectable
2azyA-5jxxA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE


(Streptomyces
violaceusniger)
PF04820
(Trp_halogenase)
5 ARG A  53
ILE A  52
ILE A 363
GLY A  60
LEU A 183
None
1.06A 2azyA-5lv9A:
undetectable
2azyA-5lv9A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxe F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE 1


(Rhodococcus
jostii)
PF00296
(Bac_luciferase)
5 ARG A 297
ILE A 296
ILE A 284
TYR A 202
GLY A 303
None
1.20A 2azyA-5lxeA:
undetectable
2azyA-5lxeA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT


(Oryctolagus
cuniculus)
no annotation 5 ILE B 256
ILE B 364
TYR B 416
GLY B 264
LEU B 543
None
1.17A 2azyA-5w7aB:
undetectable
2azyA-5w7aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wl2 -

(-)
no annotation 5 ARG H  98
ILE H  34
ILE H  51
GLY H 112
TYR H  80
None
1.21A 2azyA-5wl2H:
undetectable
2azyA-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhw PUTATIVE
6-DEOXY-D-MANNOHEPTO
SE PATHWAY PROTEIN


(Yersinia
pseudotuberculosis)
no annotation 5 ILE A 177
ILE A  90
GLY A 197
LEU A 192
PHE A 191
None
1.21A 2azyA-5xhwA:
undetectable
2azyA-5xhwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S4


(Trichomonas
vaginalis)
PF00900
(Ribosomal_S4e)
PF01479
(S4)
PF08071
(RS4NT)
PF16121
(40S_S4_C)
5 ARG E 100
ILE E 101
GLY E  91
PHE E  47
TYR E  82
None
1.19A 2azyA-5xyiE:
undetectable
2azyA-5xyiE:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens)
no annotation 5 ARG A1000
ILE A 909
HIS A1007
GLY A1040
LEU A1025
None
1.04A 2azyA-6ez8A:
undetectable
2azyA-6ez8A:
undetectable