SIMILAR PATTERNS OF AMINO ACIDS FOR 2AVV_E_MK1E902_4
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b65 | PROTEIN(AMINOPEPTIDASE) (Ochrobactrumanthropi) |
PF03576(Peptidase_S58) | 3 | ARG A 53VAL A 158GLY A 181 | None | 0.58A | 2avvE-1b65A:0.0 | 2avvE-1b65A:13.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c1d | L-PHENYLALANINEDEHYDROGENASE (Rhodococcus sp.) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | ARG A 277VAL A 243GLY A 259 | None | 0.65A | 2avvE-1c1dA:0.0 | 2avvE-1c1dA:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ci9 | PROTEIN(CARBOXYLESTERASE) (Burkholderiagladioli) |
PF00144(Beta-lactamase) | 3 | ARG A 240VAL A 264GLY A 279 | None | 0.60A | 2avvE-1ci9A:0.0 | 2avvE-1ci9A:12.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1crz | TOLB PROTEIN (Escherichiacoli) |
PF04052(TolB_N)PF07676(PD40) | 3 | ARG A 14VAL A 37GLY A 81 | None | 0.63A | 2avvE-1crzA:0.0 | 2avvE-1crzA:14.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dgj | ALDEHYDEOXIDOREDUCTASE (Desulfovibriodesulfuricans) |
PF00111(Fer2)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2) | 3 | ARG A 182VAL A 391GLY A 699 | NoneNoneMCN A 914 (-4.6A) | 0.65A | 2avvE-1dgjA:0.0 | 2avvE-1dgjA:8.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1efp | PROTEIN (ELECTRONTRANSFERFLAVOPROTEIN) (Paracoccusdenitrificans) |
PF00766(ETF_alpha)PF01012(ETF) | 3 | ARG B 230VAL A 241GLY A 199 | None | 0.64A | 2avvE-1efpB:0.0 | 2avvE-1efpB:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ej6 | LAMBDA1 (Reovirus sp.) |
no annotation | 3 | ARG B 462VAL B 450GLY B 377 | None | 0.61A | 2avvE-1ej6B:0.0 | 2avvE-1ej6B:5.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g7r | TRANSLATIONINITIATION FACTORIF2/EIF5B (Methanothermobacterthermautotrophicus) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF11987(IF-2)PF14578(GTP_EFTU_D4) | 3 | ARG A 119VAL A 127GLY A 106 | None | 0.65A | 2avvE-1g7rA:0.0 | 2avvE-1g7rA:10.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h7k | CATALASE (Proteusmirabilis) |
PF00199(Catalase)PF06628(Catalase-rel) | 3 | ARG A 333VAL A 211GLY A 321 | HEM A 600 (-3.5A)NoneNone | 0.64A | 2avvE-1h7kA:undetectable | 2avvE-1h7kA:13.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iaw | TYPE II RESTRICTIONENZYME NAEI (Lechevalieriaaerocolonigenes) |
PF09126(NaeI) | 3 | ARG A 215VAL A 201GLY A 235 | None | 0.62A | 2avvE-1iawA:undetectable | 2avvE-1iawA:13.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iov | D-ALA:D-ALA LIGASE (Escherichiacoli) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 3 | ARG A 288VAL A 298GLY A 23 | None | 0.65A | 2avvE-1iovA:undetectable | 2avvE-1iovA:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jvb | NAD(H)-DEPENDENTALCOHOLDEHYDROGENASE (Sulfolobussolfataricus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | ARG A 342VAL A 314GLY A 304 | None | 0.42A | 2avvE-1jvbA:undetectable | 2avvE-1jvbA:14.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k2w | SORBITOLDEHYDROGENASE (Rhodobactersphaeroides) |
PF13561(adh_short_C2) | 3 | ARG A 210VAL A 184GLY A 252 | None | 0.56A | 2avvE-1k2wA:undetectable | 2avvE-1k2wA:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kfw | CHITINASE B (Arthrobactersp. TAD20) |
PF00704(Glyco_hydro_18) | 3 | ARG A 431VAL A 438GLY A 322 | None | 0.53A | 2avvE-1kfwA:undetectable | 2avvE-1kfwA:13.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lox | 15-LIPOXYGENASE (Oryctolaguscuniculus) |
PF00305(Lipoxygenase)PF01477(PLAT) | 3 | ARG A 64VAL A 83GLY A 2 | None | 0.57A | 2avvE-1loxA:undetectable | 2avvE-1loxA:11.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m2w | MANNITOLDEHYDROGENASE (Pseudomonasfluorescens) |
PF01232(Mannitol_dh)PF08125(Mannitol_dh_C) | 3 | ARG A 39VAL A 96GLY A 249 | None | 0.63A | 2avvE-1m2wA:undetectable | 2avvE-1m2wA:11.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhs | PLASMA MEMBRANEATPASE (Neurosporacrassa) |
PF00122(E1-E2_ATPase)PF00690(Cation_ATPase_N)PF00702(Hydrolase) | 3 | ARG A 715VAL A 723GLY A 145 | None | 0.45A | 2avvE-1mhsA:undetectable | 2avvE-1mhsA:8.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mty | METHANEMONOOXYGENASEHYDROXYLASE (Methylococcuscapsulatus) |
PF02332(Phenol_Hydrox) | 3 | ARG B 168VAL D 112GLY D 183 | None | 0.48A | 2avvE-1mtyB:undetectable | 2avvE-1mtyB:13.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n76 | LACTOFERRIN (Homo sapiens) |
PF00405(Transferrin) | 3 | ARG A 690VAL A 399GLY A 664 | None | 0.64A | 2avvE-1n76A:undetectable | 2avvE-1n76A:9.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nl3 | PREPROTEINTRANSLOCASE SECA 1SUBUNIT (Mycobacteriumtuberculosis) |
PF01043(SecA_PP_bind)PF07516(SecA_SW)PF07517(SecA_DEAD) | 3 | ARG A 661VAL A 774GLY A 828 | None | 0.57A | 2avvE-1nl3A:undetectable | 2avvE-1nl3A:7.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pn3 | GLYCOSYLTRANSFERASEGTFA (Amycolatopsisorientalis) |
PF03033(Glyco_transf_28) | 3 | ARG A 157VAL A 86GLY A 7 | None | 0.61A | 2avvE-1pn3A:undetectable | 2avvE-1pn3A:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5a | EP-CADHERIN (Mus musculus) |
PF00028(Cadherin) | 3 | ARG A 347VAL A 381GLY A 372 | None | 0.39A | 2avvE-1q5aA:undetectable | 2avvE-1q5aA:8.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5a | EP-CADHERIN (Mus musculus) |
PF00028(Cadherin) | 3 | ARG A 347VAL A 388GLY A 372 | None | 0.60A | 2avvE-1q5aA:undetectable | 2avvE-1q5aA:8.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qd1 | FORMIMINOTRANSFERASE-CYCLODEAMINASE (Sus scrofa) |
PF02971(FTCD)PF07837(FTCD_N) | 3 | ARG A 67VAL A 123GLY A 177 | None | 0.61A | 2avvE-1qd1A:undetectable | 2avvE-1qd1A:13.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qf7 | PROTEIN (CATALASEHPII) (Escherichiacoli) |
PF00199(Catalase)PF06628(Catalase-rel) | 3 | ARG A 411VAL A 289GLY A 399 | HEM A 754 (-3.5A)NoneNone | 0.64A | 2avvE-1qf7A:undetectable | 2avvE-1qf7A:9.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t6x | RIBOFLAVINKINASE/FMNADENYLYLTRANSFERASE (Thermotogamaritima) |
PF01687(Flavokinase)PF06574(FAD_syn) | 3 | ARG A 103VAL A 86GLY A 119 | None | 0.58A | 2avvE-1t6xA:undetectable | 2avvE-1t6xA:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqj | RIBULOSE-PHOSPHATE3-EPIMERASE (Synechocystissp.) |
PF00834(Ribul_P_3_epim) | 3 | ARG A 218VAL A 190GLY A 181 | None | 0.59A | 2avvE-1tqjA:undetectable | 2avvE-1tqjA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u3d | CRYPTOCHROME 1APOPROTEIN (Arabidopsisthaliana) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 3 | ARG A 20VAL A 261GLY A 295 | None | 0.66A | 2avvE-1u3dA:undetectable | 2avvE-1u3dA:11.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uaq | CYTOSINE DEAMINASE (Saccharomycescerevisiae) |
PF00383(dCMP_cyt_deam_1) | 3 | ARG A 105VAL A 45GLY A 49 | None | 0.64A | 2avvE-1uaqA:undetectable | 2avvE-1uaqA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ufv | PANTOATE-BETA-ALANINE LIGASE (Thermusthermophilus) |
PF02569(Pantoate_ligase) | 3 | ARG A 154VAL A 22GLY A 31 | None | 0.60A | 2avvE-1ufvA:undetectable | 2avvE-1ufvA:15.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vgw | 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL SYNTHASE (Neisseriagonorrhoeae) |
PF01128(IspD) | 3 | ARG A 82VAL A 194GLY A 173 | None | 0.62A | 2avvE-1vgwA:undetectable | 2avvE-1vgwA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w55 | ISPD/ISPFBIFUNCTIONAL ENZYME (Campylobacterjejuni) |
PF01128(IspD)PF02542(YgbB) | 3 | ARG A 27VAL A 97GLY A 12 | None C A1373 (-4.4A) C A1373 ( 4.1A) | 0.59A | 2avvE-1w55A:undetectable | 2avvE-1w55A:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w8o | BACTERIAL SIALIDASE (Micromonosporaviridifaciens) |
PF00754(F5_F8_type_C)PF10633(NPCBM_assoc)PF13088(BNR_2) | 3 | ARG A 200VAL A 148GLY A 95 | None | 0.32A | 2avvE-1w8oA:undetectable | 2avvE-1w8oA:9.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xap | RETINOIC ACIDRECEPTOR BETA (Homo sapiens) |
PF00104(Hormone_recep) | 3 | ARG A 269VAL A 302GLY A 294 | TTB A 1 (-3.3A)NoneNone | 0.61A | 2avvE-1xapA:undetectable | 2avvE-1xapA:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xu1 | TUMOR NECROSISFACTOR LIGANDSUPERFAMILY MEMBER13 (Mus musculus) |
PF00229(TNF) | 3 | ARG A 189VAL A 173GLY A 237 | None | 0.56A | 2avvE-1xu1A:undetectable | 2avvE-1xu1A:24.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ya0 | SMG-7 TRANSCRIPTVARIANT 2 (Homo sapiens) |
PF10373(EST1_DNA_bind)PF10374(EST1) | 3 | ARG A 455VAL A 299GLY A 423 | None | 0.45A | 2avvE-1ya0A:undetectable | 2avvE-1ya0A:10.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ybt | HYDROLASE,ALPHA/BETA HYDROLASEFOLD FAMILY (Mycobacteriumtuberculosis) |
PF00211(Guanylate_cyc) | 3 | ARG A 430VAL A 422GLY A 379 | None | 0.53A | 2avvE-1ybtA:undetectable | 2avvE-1ybtA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ye9 | CATALASE HPII (Escherichiacoli) |
PF00199(Catalase)PF06628(Catalase-rel) | 3 | ARG E 411VAL A 289GLY E 399 | HDD E 760 (-3.8A)NoneNone | 0.62A | 2avvE-1ye9E:undetectable | 2avvE-1ye9E:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ym0 | FIBRINOTIC ENZYMECOMPONENT B (Eisenia fetida) |
PF00089(Trypsin) | 3 | ARG A 134VAL A 231GLY A 197 | SO4 A 502 ( 3.6A)NoneNone | 0.49A | 2avvE-1ym0A:undetectable | 2avvE-1ym0A:16.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ysj | PROTEIN YXEP (Bacillussubtilis) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 3 | ARG A 233VAL A 229GLY A 212 | None | 0.62A | 2avvE-1ysjA:undetectable | 2avvE-1ysjA:13.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yz4 | DUAL SPECIFICITYPHOSPHATASE-LIKE 15ISOFORM A (Homo sapiens) |
PF00782(DSPc) | 3 | ARG A 132VAL A 99GLY A 15 | None | 0.54A | 2avvE-1yz4A:undetectable | 2avvE-1yz4A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z2z | PROBABLE TRNAPSEUDOURIDINESYNTHASE D (Methanosarcinamazei) |
PF01142(TruD) | 3 | ARG A 259VAL A 270GLY A 370 | None | 0.58A | 2avvE-1z2zA:undetectable | 2avvE-1z2zA:12.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zvu | TOPOISOMERASE IVSUBUNIT A (Escherichiacoli) |
PF00521(DNA_topoisoIV)PF03989(DNA_gyraseA_C) | 3 | ARG A 29VAL A 340GLY A 237 | None | 0.57A | 2avvE-1zvuA:undetectable | 2avvE-1zvuA:10.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ab4 | TRNA PSEUDOURIDINESYNTHASE B (Thermotogamaritima) |
PF01472(PUA)PF01509(TruB_N)PF16198(TruB_C_2) | 3 | ARG A 218VAL A 19GLY A 36 | NoneNone U B 9 ( 3.3A) | 0.62A | 2avvE-2ab4A:undetectable | 2avvE-2ab4A:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ako | GLUTAMATE 5-KINASE (Campylobacterjejuni) |
PF00696(AA_kinase) | 3 | ARG A 23VAL A 79GLY A 72 | None | 0.59A | 2avvE-2akoA:undetectable | 2avvE-2akoA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2amc | PHENYLALANYL-TRNASYNTHETASE ALPHACHAINPHENYLALANYL-TRNASYNTHETASE BETACHAIN (Thermusthermophilus) |
PF01409(tRNA-synt_2d)PF01588(tRNA_bind)PF03147(FDX-ACB)PF03483(B3_4)PF03484(B5) | 3 | ARG B 486VAL A 223GLY A 227 | None | 0.62A | 2avvE-2amcB:undetectable | 2avvE-2amcB:8.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3x | IRON-RESPONSIVEELEMENT BINDINGPROTEIN 1 (Homo sapiens) |
PF00330(Aconitase)PF00694(Aconitase_C) | 3 | ARG A 134VAL A 531GLY A 427 | None | 0.65A | 2avvE-2b3xA:undetectable | 2avvE-2b3xA:7.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bii | NITRATE REDUCTASE[NADPH] (Ogataea angusta) |
PF00174(Oxidored_molyb)PF03404(Mo-co_dimer) | 3 | ARG A 216VAL A 138GLY A 329 | None | 0.42A | 2avvE-2biiA:undetectable | 2avvE-2biiA:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bs4 | QUINOL-FUMARATEREDUCTASE DIHEMECYTOCHROME B SUBUNITC (Wolinellasuccinogenes) |
PF01127(Sdh_cyt) | 3 | ARG C 99VAL C 89GLY C 38 | NoneNoneHEM C1255 ( 4.2A) | 0.60A | 2avvE-2bs4C:undetectable | 2avvE-2bs4C:16.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cvj | THIOREDOXINREDUCTASE RELATEDPROTEIN (Thermusthermophilus) |
PF00890(FAD_binding_2)PF07992(Pyr_redox_2) | 3 | ARG A 68VAL A 73GLY A 10 | NoneNoneFAD A2304 (-3.4A) | 0.65A | 2avvE-2cvjA:undetectable | 2avvE-2cvjA:16.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d1y | HYPOTHETICAL PROTEINTT0321 (Thermusthermophilus) |
PF13561(adh_short_C2) | 3 | ARG A 28VAL A 45GLY A 13 | NoneNoneNAD A1001 (-3.5A) | 0.62A | 2avvE-2d1yA:undetectable | 2avvE-2d1yA:15.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dkj | SERINEHYDROXYMETHYLTRANSFERASE (Thermusthermophilus) |
PF00464(SHMT) | 3 | ARG A 394VAL A 377GLY A 360 | None | 0.61A | 2avvE-2dkjA:undetectable | 2avvE-2dkjA:13.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eer | NAD-DEPENDENTALCOHOLDEHYDROGENASE (Sulfurisphaeratokodaii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | ARG A 342VAL A 314GLY A 304 | NAD A 401 (-3.0A)NoneNone | 0.52A | 2avvE-2eerA:undetectable | 2avvE-2eerA:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2epg | HYPOTHETICAL PROTEINTTHA1785 (Thermusthermophilus) |
PF01139(RtcB) | 3 | ARG A 191VAL A 250GLY A 91 | None | 0.63A | 2avvE-2epgA:undetectable | 2avvE-2epgA:11.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eq9 | PYRUVATEDEHYDROGENASECOMPLEX,DIHYDROLIPOAMIDEDEHYDROGENASE E3COMPONENT (Thermusthermophilus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 3 | ARG A 235VAL A 268GLY A 156 | None | 0.43A | 2avvE-2eq9A:undetectable | 2avvE-2eq9A:12.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fkn | UROCANATE HYDRATASE (Bacillussubtilis) |
PF01175(Urocanase)PF17391(Urocanase_N)PF17392(Urocanase_C) | 3 | ARG A 358VAL A 446GLY A 487 | ACT A 553 (-2.7A)NoneNone | 0.63A | 2avvE-2fknA:undetectable | 2avvE-2fknA:12.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gid | MITOCHONDRIALRNA-BINDING PROTEIN1 (Trypanosomabrucei) |
PF09387(MRP) | 3 | ARG B 48VAL B 37GLY B 65 | None | 0.65A | 2avvE-2gidB:undetectable | 2avvE-2gidB:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2grk | EVM001 (Ectromeliavirus) |
PF02250(Orthopox_35kD) | 3 | ARG A 164VAL A 186GLY A 170 | None | 0.52A | 2avvE-2grkA:undetectable | 2avvE-2grkA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h0q | SUPPRESSOR OF T-CELLRECEPTOR SIGNALING 1 (Mus musculus) |
PF00300(His_Phos_1) | 3 | ARG A 405VAL A 387GLY A 381 | None | 0.66A | 2avvE-2h0qA:undetectable | 2avvE-2h0qA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hc8 | CATION-TRANSPORTINGATPASE, P-TYPE (Archaeoglobusfulgidus) |
PF00122(E1-E2_ATPase) | 3 | ARG A 252VAL A 264GLY A 246 | None | 0.51A | 2avvE-2hc8A:undetectable | 2avvE-2hc8A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hcs | RNA-DIRECTED RNAPOLYMERASE (NS5) (West Nile virus) |
PF00972(Flavi_NS5) | 3 | ARG A 328VAL A 753GLY A 880 | None | 0.62A | 2avvE-2hcsA:undetectable | 2avvE-2hcsA:10.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hg4 | 6-DEOXYERYTHRONOLIDEB SYNTHASE (Saccharopolysporaerythraea) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF08990(Docking)PF16197(KAsynt_C_assoc) | 3 | ARG A 215VAL A 293GLY A 202 | None | 0.50A | 2avvE-2hg4A:undetectable | 2avvE-2hg4A:8.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hpi | DNA POLYMERASE IIIALPHA SUBUNIT (Thermusaquaticus) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 3 | ARG A1164VAL A1015GLY A1075 | None | 0.65A | 2avvE-2hpiA:undetectable | 2avvE-2hpiA:5.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hrz | NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE (Agrobacteriumfabrum) |
PF01370(Epimerase) | 3 | ARG A 285VAL A 213GLY A 194 | None | 0.66A | 2avvE-2hrzA:undetectable | 2avvE-2hrzA:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hwx | TELOMERASE-BINDINGPROTEIN EST1A (Homo sapiens) |
PF13638(PIN_4) | 3 | ARG A1321VAL A1274GLY A1332 | None | 0.50A | 2avvE-2hwxA:undetectable | 2avvE-2hwxA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i2x | METHYLTRANSFERASE 1 (Methanosarcinabarkeri) |
PF12176(MtaB) | 3 | ARG A 5VAL A 276GLY A 264 | None | 0.62A | 2avvE-2i2xA:undetectable | 2avvE-2i2xA:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9e | TRIOSEPHOSPHATEISOMERASE (Tenebriomolitor) |
PF00121(TIM) | 3 | ARG A 144VAL A 183GLY A 208 | None | 0.61A | 2avvE-2i9eA:undetectable | 2avvE-2i9eA:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iec | UNCHARACTERIZEDPROTEIN CONSERVED INARCHAEA (Methanopyruskandleri) |
PF04038(DHNA) | 3 | ARG A 51VAL A 66GLY A 34 | None | 0.62A | 2avvE-2iecA:undetectable | 2avvE-2iecA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ihd | REGULATOR OFG-PROTEIN SIGNALING8 (Homo sapiens) |
PF00615(RGS) | 3 | ARG A 71VAL A 121GLY A 148 | NoneNone CL A 1 ( 4.2A) | 0.43A | 2avvE-2ihdA:undetectable | 2avvE-2ihdA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iic | ALPHA-11 GIARDIN (Giardiaintestinalis) |
no annotation | 3 | ARG A 105VAL A 79GLY A 257 | None | 0.60A | 2avvE-2iicA:undetectable | 2avvE-2iicA:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ipi | ACLACINOMYCINOXIDOREDUCTASE(AKNOX) (Streptomycesgalilaeus) |
PF01565(FAD_binding_4)PF08031(BBE) | 3 | ARG A 27VAL A 49GLY A 201 | None | 0.57A | 2avvE-2ipiA:undetectable | 2avvE-2ipiA:11.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iqf | CATALASE (Helicobacterpylori) |
PF00199(Catalase)PF06628(Catalase-rel) | 3 | ARG A 335VAL A 213GLY A 323 | HEM A 550 (-3.5A)NoneNone | 0.61A | 2avvE-2iqfA:undetectable | 2avvE-2iqfA:9.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isa | CATALASE (Aliivibriosalmonicida) |
PF00199(Catalase)PF06628(Catalase-rel) | 3 | ARG A 333VAL A 211GLY A 321 | HEM A 486 (-3.5A)NoneNone | 0.52A | 2avvE-2isaA:undetectable | 2avvE-2isaA:12.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2itb | TRNA-(MS(2)IO(6)A)-HYDROXYLASE, PUTATIVE (Pseudomonasputida) |
PF06175(MiaE) | 3 | ARG A 173VAL A 117GLY A 98 | EDO A 509 (-4.6A)EDO A 506 (-4.2A)None | 0.63A | 2avvE-2itbA:undetectable | 2avvE-2itbA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jb1 | L-AMINO ACID OXIDASE (Rhodococcusopacus) |
PF01593(Amino_oxidase) | 3 | ARG A 55VAL A 368GLY A 322 | None | 0.56A | 2avvE-2jb1A:undetectable | 2avvE-2jb1A:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2le1 | UNCHARACTERIZEDPROTEIN (Thermobifidafusca) |
PF10604(Polyketide_cyc2) | 3 | ARG A 68VAL A 105GLY A 133 | None | 0.43A | 2avvE-2le1A:undetectable | 2avvE-2le1A:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n7p | PUTATIVEUNCHARACTERIZEDPROTEIN (Trypanosomabrucei) |
no annotation | 3 | ARG A 90VAL A 28GLY A 43 | None | 0.48A | 2avvE-2n7pA:undetectable | 2avvE-2n7pA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nrj | HBL B PROTEIN (Bacillus cereus) |
PF05791(Bacillus_HBL) | 3 | ARG A 250VAL A 223GLY A 229 | None | 0.65A | 2avvE-2nrjA:undetectable | 2avvE-2nrjA:13.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o7q | BIFUNCTIONAL3-DEHYDROQUINATEDEHYDRATASE/SHIKIMATE DEHYDROGENASE (Arabidopsisthaliana) |
PF01487(DHquinase_I)PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 3 | ARG A 488VAL A 458GLY A 471 | NoneNoneCSO A 424 ( 3.4A) | 0.62A | 2avvE-2o7qA:undetectable | 2avvE-2o7qA:13.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2owo | DNA LIGASE (Escherichiacoli) |
PF01653(DNA_ligase_aden)PF03119(DNA_ligase_ZBD)PF03120(DNA_ligase_OB)PF12826(HHH_2)PF14520(HHH_5) | 3 | ARG A 366VAL A 402GLY A 372 | None | 0.65A | 2avvE-2owoA:undetectable | 2avvE-2owoA:8.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p0q | ALR1010 PROTEIN (Nostoc sp. PCC7120) |
PF11535(Calci_bind_CcbP) | 3 | ARG A 13VAL A 4GLY A 123 | None | 0.57A | 2avvE-2p0qA:undetectable | 2avvE-2p0qA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p68 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Aquifexaeolicus) |
PF13561(adh_short_C2) | 3 | ARG A 43VAL A 34GLY A 56 | None | 0.55A | 2avvE-2p68A:undetectable | 2avvE-2p68A:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q01 | URONATE ISOMERASE (Caulobactervibrioides) |
PF02614(UxaC) | 3 | ARG A 20VAL A 429GLY A 393 | None | 0.60A | 2avvE-2q01A:undetectable | 2avvE-2q01A:11.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q6u | NIKD PROTEIN (Streptomycestendae) |
PF01266(DAO) | 3 | ARG A 29VAL A 200GLY A 11 | NoneNoneFAD A 401 ( 3.3A) | 0.56A | 2avvE-2q6uA:undetectable | 2avvE-2q6uA:12.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qbu | PRECORRIN-2METHYLTRANSFERASE (Methanothermobacterthermautotrophicus) |
PF00590(TP_methylase) | 3 | ARG A 143VAL A 209GLY A 217 | None | 0.63A | 2avvE-2qbuA:undetectable | 2avvE-2qbuA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qpw | PR DOMAIN ZINCFINGER PROTEIN 2 (Homo sapiens) |
PF00856(SET) | 3 | ARG A 40VAL A 29GLY A 24 | None | 0.65A | 2avvE-2qpwA:undetectable | 2avvE-2qpwA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qvw | GLP_546_48378_50642 (Giardiaintestinalis) |
PF00636(Ribonuclease_3)PF02170(PAZ) | 3 | ARG A 569VAL A 588GLY A 508 | None | 0.64A | 2avvE-2qvwA:undetectable | 2avvE-2qvwA:9.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qw8 | EUGENOL SYNTHASE 1 (Ocimumbasilicum) |
PF05368(NmrA) | 3 | ARG A 136VAL A 197GLY A 191 | None | 0.59A | 2avvE-2qw8A:undetectable | 2avvE-2qw8A:14.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vod | LUPUS LA PROTEIN (Homo sapiens) |
PF00076(RRM_1)PF05383(La) | 3 | ARG A 57VAL A 156GLY A 135 | None | 0.35A | 2avvE-2vodA:undetectable | 2avvE-2vodA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vpj | KELCH-LIKE PROTEIN12 (Homo sapiens) |
PF01344(Kelch_1) | 3 | ARG A 320VAL A 285GLY A 554 | None | 0.61A | 2avvE-2vpjA:undetectable | 2avvE-2vpjA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w40 | GLYCEROL KINASE,PUTATIVE (Plasmodiumfalciparum) |
PF00370(FGGY_N)PF02782(FGGY_C) | 3 | ARG A 83VAL A 441GLY A 414 | GOL A1511 (-3.8A)NoneNone | 0.61A | 2avvE-2w40A:undetectable | 2avvE-2w40A:11.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w92 | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE D (Streptococcuspneumoniae) |
PF03644(Glyco_hydro_85) | 3 | ARG A 210VAL A 273GLY A 286 | None | 0.60A | 2avvE-2w92A:undetectable | 2avvE-2w92A:9.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wdw | PUTATIVE HEXOSEOXIDASE (Nonomuraeagerenzanensis) |
PF01565(FAD_binding_4)PF08031(BBE) | 3 | ARG A 48VAL A 70GLY A 222 | None | 0.60A | 2avvE-2wdwA:undetectable | 2avvE-2wdwA:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wgp | DUAL SPECIFICITYPROTEIN PHOSPHATASE14 (Homo sapiens) |
PF00782(DSPc) | 3 | ARG A 117VAL A 147GLY A 25 | PO4 A 200 (-3.9A)NoneNone | 0.57A | 2avvE-2wgpA:undetectable | 2avvE-2wgpA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x5d | PROBABLEAMINOTRANSFERASE (Pseudomonasaeruginosa) |
PF00155(Aminotran_1_2) | 3 | ARG A 163VAL A 152GLY A 365 | None | 0.66A | 2avvE-2x5dA:undetectable | 2avvE-2x5dA:13.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yoy | RBAM17540 (Bacillusamyloliquefaciens) |
PF03067(LPMO_10) | 3 | ARG A 37VAL A 186GLY A 77 | None | 0.64A | 2avvE-2yoyA:undetectable | 2avvE-2yoyA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yw4 | 4-HYDROXY-2-OXOGLUTARATEALDOLASE/2-DEYDRO-3-DEOXYPHOSPHOGLUCONATE ALDOLASE (Thermusthermophilus) |
PF01081(Aldolase) | 3 | ARG A 143VAL A 177GLY A 159 | None | 0.61A | 2avvE-2yw4A:undetectable | 2avvE-2yw4A:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zcv | UNCHARACTERIZEDOXIDOREDUCTASE YTFG (Escherichiacoli) |
PF05368(NmrA) | 3 | ARG A 171VAL A 77GLY A 113 | NDP A 400 (-4.1A)NoneNone | 0.57A | 2avvE-2zcvA:undetectable | 2avvE-2zcvA:16.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zfu | CEREBRAL PROTEIN 1 (Homo sapiens) |
PF05148(Methyltransf_8) | 3 | ARG A 298VAL A 415GLY A 386 | None | 0.66A | 2avvE-2zfuA:undetectable | 2avvE-2zfuA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zwv | PROBABLE RIBOSOMALRNA SMALL SUBUNITMETHYLTRANSFERASE (Thermusthermophilus) |
PF05175(MTS) | 3 | ARG A 163VAL A 106GLY A 57 | None | 0.53A | 2avvE-2zwvA:undetectable | 2avvE-2zwvA:14.63 |