SIMILAR PATTERNS OF AMINO ACIDS FOR 2AVV_E_MK1E902_4

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b65 PROTEIN
(AMINOPEPTIDASE)


(Ochrobactrum
anthropi)
PF03576
(Peptidase_S58)
3 ARG A  53
VAL A 158
GLY A 181
None
0.58A 2avvE-1b65A:
0.0
2avvE-1b65A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1d L-PHENYLALANINE
DEHYDROGENASE


(Rhodococcus sp.)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
3 ARG A 277
VAL A 243
GLY A 259
None
0.65A 2avvE-1c1dA:
0.0
2avvE-1c1dA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)


(Burkholderia
gladioli)
PF00144
(Beta-lactamase)
3 ARG A 240
VAL A 264
GLY A 279
None
0.60A 2avvE-1ci9A:
0.0
2avvE-1ci9A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crz TOLB PROTEIN

(Escherichia
coli)
PF04052
(TolB_N)
PF07676
(PD40)
3 ARG A  14
VAL A  37
GLY A  81
None
0.63A 2avvE-1crzA:
0.0
2avvE-1crzA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE


(Desulfovibrio
desulfuricans)
PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
3 ARG A 182
VAL A 391
GLY A 699
None
None
MCN  A 914 (-4.6A)
0.65A 2avvE-1dgjA:
0.0
2avvE-1dgjA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)


(Paracoccus
denitrificans)
PF00766
(ETF_alpha)
PF01012
(ETF)
3 ARG B 230
VAL A 241
GLY A 199
None
0.64A 2avvE-1efpB:
0.0
2avvE-1efpB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.)
no annotation 3 ARG B 462
VAL B 450
GLY B 377
None
0.61A 2avvE-1ej6B:
0.0
2avvE-1ej6B:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7r TRANSLATION
INITIATION FACTOR
IF2/EIF5B


(Methanothermobacter
thermautotrophicus)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4)
3 ARG A 119
VAL A 127
GLY A 106
None
0.65A 2avvE-1g7rA:
0.0
2avvE-1g7rA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7k CATALASE

(Proteus
mirabilis)
PF00199
(Catalase)
PF06628
(Catalase-rel)
3 ARG A 333
VAL A 211
GLY A 321
HEM  A 600 (-3.5A)
None
None
0.64A 2avvE-1h7kA:
undetectable
2avvE-1h7kA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iaw TYPE II RESTRICTION
ENZYME NAEI


(Lechevalieria
aerocolonigenes)
PF09126
(NaeI)
3 ARG A 215
VAL A 201
GLY A 235
None
0.62A 2avvE-1iawA:
undetectable
2avvE-1iawA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iov D-ALA:D-ALA LIGASE

(Escherichia
coli)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
3 ARG A 288
VAL A 298
GLY A  23
None
0.65A 2avvE-1iovA:
undetectable
2avvE-1iovA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Sulfolobus
solfataricus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 ARG A 342
VAL A 314
GLY A 304
None
0.42A 2avvE-1jvbA:
undetectable
2avvE-1jvbA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2w SORBITOL
DEHYDROGENASE


(Rhodobacter
sphaeroides)
PF13561
(adh_short_C2)
3 ARG A 210
VAL A 184
GLY A 252
None
0.56A 2avvE-1k2wA:
undetectable
2avvE-1k2wA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20)
PF00704
(Glyco_hydro_18)
3 ARG A 431
VAL A 438
GLY A 322
None
0.53A 2avvE-1kfwA:
undetectable
2avvE-1kfwA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
3 ARG A  64
VAL A  83
GLY A   2
None
0.57A 2avvE-1loxA:
undetectable
2avvE-1loxA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE


(Pseudomonas
fluorescens)
PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C)
3 ARG A  39
VAL A  96
GLY A 249
None
0.63A 2avvE-1m2wA:
undetectable
2avvE-1m2wA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE


(Neurospora
crassa)
PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase)
3 ARG A 715
VAL A 723
GLY A 145
None
0.45A 2avvE-1mhsA:
undetectable
2avvE-1mhsA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE


(Methylococcus
capsulatus)
PF02332
(Phenol_Hydrox)
3 ARG B 168
VAL D 112
GLY D 183
None
0.48A 2avvE-1mtyB:
undetectable
2avvE-1mtyB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens)
PF00405
(Transferrin)
3 ARG A 690
VAL A 399
GLY A 664
None
0.64A 2avvE-1n76A:
undetectable
2avvE-1n76A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT


(Mycobacterium
tuberculosis)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD)
3 ARG A 661
VAL A 774
GLY A 828
None
0.57A 2avvE-1nl3A:
undetectable
2avvE-1nl3A:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn3 GLYCOSYLTRANSFERASE
GTFA


(Amycolatopsis
orientalis)
PF03033
(Glyco_transf_28)
3 ARG A 157
VAL A  86
GLY A   7
None
0.61A 2avvE-1pn3A:
undetectable
2avvE-1pn3A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus)
PF00028
(Cadherin)
3 ARG A 347
VAL A 381
GLY A 372
None
0.39A 2avvE-1q5aA:
undetectable
2avvE-1q5aA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus)
PF00028
(Cadherin)
3 ARG A 347
VAL A 388
GLY A 372
None
0.60A 2avvE-1q5aA:
undetectable
2avvE-1q5aA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE


(Sus scrofa)
PF02971
(FTCD)
PF07837
(FTCD_N)
3 ARG A  67
VAL A 123
GLY A 177
None
0.61A 2avvE-1qd1A:
undetectable
2avvE-1qd1A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)


(Escherichia
coli)
PF00199
(Catalase)
PF06628
(Catalase-rel)
3 ARG A 411
VAL A 289
GLY A 399
HEM  A 754 (-3.5A)
None
None
0.64A 2avvE-1qf7A:
undetectable
2avvE-1qf7A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE


(Thermotoga
maritima)
PF01687
(Flavokinase)
PF06574
(FAD_syn)
3 ARG A 103
VAL A  86
GLY A 119
None
0.58A 2avvE-1t6xA:
undetectable
2avvE-1t6xA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqj RIBULOSE-PHOSPHATE
3-EPIMERASE


(Synechocystis
sp.)
PF00834
(Ribul_P_3_epim)
3 ARG A 218
VAL A 190
GLY A 181
None
0.59A 2avvE-1tqjA:
undetectable
2avvE-1tqjA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3d CRYPTOCHROME 1
APOPROTEIN


(Arabidopsis
thaliana)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
3 ARG A  20
VAL A 261
GLY A 295
None
0.66A 2avvE-1u3dA:
undetectable
2avvE-1u3dA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaq CYTOSINE DEAMINASE

(Saccharomyces
cerevisiae)
PF00383
(dCMP_cyt_deam_1)
3 ARG A 105
VAL A  45
GLY A  49
None
0.64A 2avvE-1uaqA:
undetectable
2avvE-1uaqA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufv PANTOATE-BETA-ALANIN
E LIGASE


(Thermus
thermophilus)
PF02569
(Pantoate_ligase)
3 ARG A 154
VAL A  22
GLY A  31
None
0.60A 2avvE-1ufvA:
undetectable
2avvE-1ufvA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE


(Neisseria
gonorrhoeae)
PF01128
(IspD)
3 ARG A  82
VAL A 194
GLY A 173
None
0.62A 2avvE-1vgwA:
undetectable
2avvE-1vgwA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME


(Campylobacter
jejuni)
PF01128
(IspD)
PF02542
(YgbB)
3 ARG A  27
VAL A  97
GLY A  12
None
C  A1373 (-4.4A)
C  A1373 ( 4.1A)
0.59A 2avvE-1w55A:
undetectable
2avvE-1w55A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens)
PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2)
3 ARG A 200
VAL A 148
GLY A  95
None
0.32A 2avvE-1w8oA:
undetectable
2avvE-1w8oA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xap RETINOIC ACID
RECEPTOR BETA


(Homo sapiens)
PF00104
(Hormone_recep)
3 ARG A 269
VAL A 302
GLY A 294
TTB  A   1 (-3.3A)
None
None
0.61A 2avvE-1xapA:
undetectable
2avvE-1xapA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xu1 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13


(Mus musculus)
PF00229
(TNF)
3 ARG A 189
VAL A 173
GLY A 237
None
0.56A 2avvE-1xu1A:
undetectable
2avvE-1xu1A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ya0 SMG-7 TRANSCRIPT
VARIANT 2


(Homo sapiens)
PF10373
(EST1_DNA_bind)
PF10374
(EST1)
3 ARG A 455
VAL A 299
GLY A 423
None
0.45A 2avvE-1ya0A:
undetectable
2avvE-1ya0A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybt HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY


(Mycobacterium
tuberculosis)
PF00211
(Guanylate_cyc)
3 ARG A 430
VAL A 422
GLY A 379
None
0.53A 2avvE-1ybtA:
undetectable
2avvE-1ybtA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye9 CATALASE HPII

(Escherichia
coli)
PF00199
(Catalase)
PF06628
(Catalase-rel)
3 ARG E 411
VAL A 289
GLY E 399
HDD  E 760 (-3.8A)
None
None
0.62A 2avvE-1ye9E:
undetectable
2avvE-1ye9E:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ym0 FIBRINOTIC ENZYME
COMPONENT B


(Eisenia fetida)
PF00089
(Trypsin)
3 ARG A 134
VAL A 231
GLY A 197
SO4  A 502 ( 3.6A)
None
None
0.49A 2avvE-1ym0A:
undetectable
2avvE-1ym0A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
3 ARG A 233
VAL A 229
GLY A 212
None
0.62A 2avvE-1ysjA:
undetectable
2avvE-1ysjA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A


(Homo sapiens)
PF00782
(DSPc)
3 ARG A 132
VAL A  99
GLY A  15
None
0.54A 2avvE-1yz4A:
undetectable
2avvE-1yz4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D


(Methanosarcina
mazei)
PF01142
(TruD)
3 ARG A 259
VAL A 270
GLY A 370
None
0.58A 2avvE-1z2zA:
undetectable
2avvE-1z2zA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvu TOPOISOMERASE IV
SUBUNIT A


(Escherichia
coli)
PF00521
(DNA_topoisoIV)
PF03989
(DNA_gyraseA_C)
3 ARG A  29
VAL A 340
GLY A 237
None
0.57A 2avvE-1zvuA:
undetectable
2avvE-1zvuA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ab4 TRNA PSEUDOURIDINE
SYNTHASE B


(Thermotoga
maritima)
PF01472
(PUA)
PF01509
(TruB_N)
PF16198
(TruB_C_2)
3 ARG A 218
VAL A  19
GLY A  36
None
None
U  B   9 ( 3.3A)
0.62A 2avvE-2ab4A:
undetectable
2avvE-2ab4A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ako GLUTAMATE 5-KINASE

(Campylobacter
jejuni)
PF00696
(AA_kinase)
3 ARG A  23
VAL A  79
GLY A  72
None
0.59A 2avvE-2akoA:
undetectable
2avvE-2akoA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN


(Thermus
thermophilus)
PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5)
3 ARG B 486
VAL A 223
GLY A 227
None
0.62A 2avvE-2amcB:
undetectable
2avvE-2amcB:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1


(Homo sapiens)
PF00330
(Aconitase)
PF00694
(Aconitase_C)
3 ARG A 134
VAL A 531
GLY A 427
None
0.65A 2avvE-2b3xA:
undetectable
2avvE-2b3xA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bii NITRATE REDUCTASE
[NADPH]


(Ogataea angusta)
PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer)
3 ARG A 216
VAL A 138
GLY A 329
None
0.42A 2avvE-2biiA:
undetectable
2avvE-2biiA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C


(Wolinella
succinogenes)
PF01127
(Sdh_cyt)
3 ARG C  99
VAL C  89
GLY C  38
None
None
HEM  C1255 ( 4.2A)
0.60A 2avvE-2bs4C:
undetectable
2avvE-2bs4C:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN


(Thermus
thermophilus)
PF00890
(FAD_binding_2)
PF07992
(Pyr_redox_2)
3 ARG A  68
VAL A  73
GLY A  10
None
None
FAD  A2304 (-3.4A)
0.65A 2avvE-2cvjA:
undetectable
2avvE-2cvjA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1y HYPOTHETICAL PROTEIN
TT0321


(Thermus
thermophilus)
PF13561
(adh_short_C2)
3 ARG A  28
VAL A  45
GLY A  13
None
None
NAD  A1001 (-3.5A)
0.62A 2avvE-2d1yA:
undetectable
2avvE-2d1yA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE


(Thermus
thermophilus)
PF00464
(SHMT)
3 ARG A 394
VAL A 377
GLY A 360
None
0.61A 2avvE-2dkjA:
undetectable
2avvE-2dkjA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Sulfurisphaera
tokodaii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 ARG A 342
VAL A 314
GLY A 304
NAD  A 401 (-3.0A)
None
None
0.52A 2avvE-2eerA:
undetectable
2avvE-2eerA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785


(Thermus
thermophilus)
PF01139
(RtcB)
3 ARG A 191
VAL A 250
GLY A  91
None
0.63A 2avvE-2epgA:
undetectable
2avvE-2epgA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT


(Thermus
thermophilus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
3 ARG A 235
VAL A 268
GLY A 156
None
0.43A 2avvE-2eq9A:
undetectable
2avvE-2eq9A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis)
PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C)
3 ARG A 358
VAL A 446
GLY A 487
ACT  A 553 (-2.7A)
None
None
0.63A 2avvE-2fknA:
undetectable
2avvE-2fknA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gid MITOCHONDRIAL
RNA-BINDING PROTEIN
1


(Trypanosoma
brucei)
PF09387
(MRP)
3 ARG B  48
VAL B  37
GLY B  65
None
0.65A 2avvE-2gidB:
undetectable
2avvE-2gidB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grk EVM001

(Ectromelia
virus)
PF02250
(Orthopox_35kD)
3 ARG A 164
VAL A 186
GLY A 170
None
0.52A 2avvE-2grkA:
undetectable
2avvE-2grkA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0q SUPPRESSOR OF T-CELL
RECEPTOR SIGNALING 1


(Mus musculus)
PF00300
(His_Phos_1)
3 ARG A 405
VAL A 387
GLY A 381
None
0.66A 2avvE-2h0qA:
undetectable
2avvE-2h0qA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hc8 CATION-TRANSPORTING
ATPASE, P-TYPE


(Archaeoglobus
fulgidus)
PF00122
(E1-E2_ATPase)
3 ARG A 252
VAL A 264
GLY A 246
None
0.51A 2avvE-2hc8A:
undetectable
2avvE-2hc8A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)


(West Nile virus)
PF00972
(Flavi_NS5)
3 ARG A 328
VAL A 753
GLY A 880
None
0.62A 2avvE-2hcsA:
undetectable
2avvE-2hcsA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE


(Saccharopolyspora
erythraea)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc)
3 ARG A 215
VAL A 293
GLY A 202
None
0.50A 2avvE-2hg4A:
undetectable
2avvE-2hg4A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT


(Thermus
aquaticus)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
3 ARG A1164
VAL A1015
GLY A1075
None
0.65A 2avvE-2hpiA:
undetectable
2avvE-2hpiA:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE


(Agrobacterium
fabrum)
PF01370
(Epimerase)
3 ARG A 285
VAL A 213
GLY A 194
None
0.66A 2avvE-2hrzA:
undetectable
2avvE-2hrzA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwx TELOMERASE-BINDING
PROTEIN EST1A


(Homo sapiens)
PF13638
(PIN_4)
3 ARG A1321
VAL A1274
GLY A1332
None
0.50A 2avvE-2hwxA:
undetectable
2avvE-2hwxA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri)
PF12176
(MtaB)
3 ARG A   5
VAL A 276
GLY A 264
None
0.62A 2avvE-2i2xA:
undetectable
2avvE-2i2xA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9e TRIOSEPHOSPHATE
ISOMERASE


(Tenebrio
molitor)
PF00121
(TIM)
3 ARG A 144
VAL A 183
GLY A 208
None
0.61A 2avvE-2i9eA:
undetectable
2avvE-2i9eA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iec UNCHARACTERIZED
PROTEIN CONSERVED IN
ARCHAEA


(Methanopyrus
kandleri)
PF04038
(DHNA)
3 ARG A  51
VAL A  66
GLY A  34
None
0.62A 2avvE-2iecA:
undetectable
2avvE-2iecA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihd REGULATOR OF
G-PROTEIN SIGNALING
8


(Homo sapiens)
PF00615
(RGS)
3 ARG A  71
VAL A 121
GLY A 148
None
None
CL  A   1 ( 4.2A)
0.43A 2avvE-2ihdA:
undetectable
2avvE-2ihdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iic ALPHA-11 GIARDIN

(Giardia
intestinalis)
no annotation 3 ARG A 105
VAL A  79
GLY A 257
None
0.60A 2avvE-2iicA:
undetectable
2avvE-2iicA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)


(Streptomyces
galilaeus)
PF01565
(FAD_binding_4)
PF08031
(BBE)
3 ARG A  27
VAL A  49
GLY A 201
None
0.57A 2avvE-2ipiA:
undetectable
2avvE-2ipiA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqf CATALASE

(Helicobacter
pylori)
PF00199
(Catalase)
PF06628
(Catalase-rel)
3 ARG A 335
VAL A 213
GLY A 323
HEM  A 550 (-3.5A)
None
None
0.61A 2avvE-2iqfA:
undetectable
2avvE-2iqfA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida)
PF00199
(Catalase)
PF06628
(Catalase-rel)
3 ARG A 333
VAL A 211
GLY A 321
HEM  A 486 (-3.5A)
None
None
0.52A 2avvE-2isaA:
undetectable
2avvE-2isaA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2itb TRNA-(MS(2)IO(6)A)-H
YDROXYLASE, PUTATIVE


(Pseudomonas
putida)
PF06175
(MiaE)
3 ARG A 173
VAL A 117
GLY A  98
EDO  A 509 (-4.6A)
EDO  A 506 (-4.2A)
None
0.63A 2avvE-2itbA:
undetectable
2avvE-2itbA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jb1 L-AMINO ACID OXIDASE

(Rhodococcus
opacus)
PF01593
(Amino_oxidase)
3 ARG A  55
VAL A 368
GLY A 322
None
0.56A 2avvE-2jb1A:
undetectable
2avvE-2jb1A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2le1 UNCHARACTERIZED
PROTEIN


(Thermobifida
fusca)
PF10604
(Polyketide_cyc2)
3 ARG A  68
VAL A 105
GLY A 133
None
0.43A 2avvE-2le1A:
undetectable
2avvE-2le1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7p PUTATIVE
UNCHARACTERIZED
PROTEIN


(Trypanosoma
brucei)
no annotation 3 ARG A  90
VAL A  28
GLY A  43
None
0.48A 2avvE-2n7pA:
undetectable
2avvE-2n7pA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrj HBL B PROTEIN

(Bacillus cereus)
PF05791
(Bacillus_HBL)
3 ARG A 250
VAL A 223
GLY A 229
None
0.65A 2avvE-2nrjA:
undetectable
2avvE-2nrjA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE


(Arabidopsis
thaliana)
PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
3 ARG A 488
VAL A 458
GLY A 471
None
None
CSO  A 424 ( 3.4A)
0.62A 2avvE-2o7qA:
undetectable
2avvE-2o7qA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owo DNA LIGASE

(Escherichia
coli)
PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5)
3 ARG A 366
VAL A 402
GLY A 372
None
0.65A 2avvE-2owoA:
undetectable
2avvE-2owoA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0q ALR1010 PROTEIN

(Nostoc sp. PCC
7120)
PF11535
(Calci_bind_CcbP)
3 ARG A  13
VAL A   4
GLY A 123
None
0.57A 2avvE-2p0qA:
undetectable
2avvE-2p0qA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p68 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Aquifex
aeolicus)
PF13561
(adh_short_C2)
3 ARG A  43
VAL A  34
GLY A  56
None
0.55A 2avvE-2p68A:
undetectable
2avvE-2p68A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides)
PF02614
(UxaC)
3 ARG A  20
VAL A 429
GLY A 393
None
0.60A 2avvE-2q01A:
undetectable
2avvE-2q01A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae)
PF01266
(DAO)
3 ARG A  29
VAL A 200
GLY A  11
None
None
FAD  A 401 ( 3.3A)
0.56A 2avvE-2q6uA:
undetectable
2avvE-2q6uA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qbu PRECORRIN-2
METHYLTRANSFERASE


(Methanothermobacter
thermautotrophicus)
PF00590
(TP_methylase)
3 ARG A 143
VAL A 209
GLY A 217
None
0.63A 2avvE-2qbuA:
undetectable
2avvE-2qbuA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpw PR DOMAIN ZINC
FINGER PROTEIN 2


(Homo sapiens)
PF00856
(SET)
3 ARG A  40
VAL A  29
GLY A  24
None
0.65A 2avvE-2qpwA:
undetectable
2avvE-2qpwA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis)
PF00636
(Ribonuclease_3)
PF02170
(PAZ)
3 ARG A 569
VAL A 588
GLY A 508
None
0.64A 2avvE-2qvwA:
undetectable
2avvE-2qvwA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw8 EUGENOL SYNTHASE 1

(Ocimum
basilicum)
PF05368
(NmrA)
3 ARG A 136
VAL A 197
GLY A 191
None
0.59A 2avvE-2qw8A:
undetectable
2avvE-2qw8A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vod LUPUS LA PROTEIN

(Homo sapiens)
PF00076
(RRM_1)
PF05383
(La)
3 ARG A  57
VAL A 156
GLY A 135
None
0.35A 2avvE-2vodA:
undetectable
2avvE-2vodA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpj KELCH-LIKE PROTEIN
12


(Homo sapiens)
PF01344
(Kelch_1)
3 ARG A 320
VAL A 285
GLY A 554
None
0.61A 2avvE-2vpjA:
undetectable
2avvE-2vpjA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE


(Plasmodium
falciparum)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
3 ARG A  83
VAL A 441
GLY A 414
GOL  A1511 (-3.8A)
None
None
0.61A 2avvE-2w40A:
undetectable
2avvE-2w40A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D


(Streptococcus
pneumoniae)
PF03644
(Glyco_hydro_85)
3 ARG A 210
VAL A 273
GLY A 286
None
0.60A 2avvE-2w92A:
undetectable
2avvE-2w92A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE


(Nonomuraea
gerenzanensis)
PF01565
(FAD_binding_4)
PF08031
(BBE)
3 ARG A  48
VAL A  70
GLY A 222
None
0.60A 2avvE-2wdwA:
undetectable
2avvE-2wdwA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgp DUAL SPECIFICITY
PROTEIN PHOSPHATASE
14


(Homo sapiens)
PF00782
(DSPc)
3 ARG A 117
VAL A 147
GLY A  25
PO4  A 200 (-3.9A)
None
None
0.57A 2avvE-2wgpA:
undetectable
2avvE-2wgpA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5d PROBABLE
AMINOTRANSFERASE


(Pseudomonas
aeruginosa)
PF00155
(Aminotran_1_2)
3 ARG A 163
VAL A 152
GLY A 365
None
0.66A 2avvE-2x5dA:
undetectable
2avvE-2x5dA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoy RBAM17540

(Bacillus
amyloliquefaciens)
PF03067
(LPMO_10)
3 ARG A  37
VAL A 186
GLY A  77
None
0.64A 2avvE-2yoyA:
undetectable
2avvE-2yoyA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw4 4-HYDROXY-2-OXOGLUTA
RATE
ALDOLASE/2-DEYDRO-3-
DEOXYPHOSPHOGLUCONAT
E ALDOLASE


(Thermus
thermophilus)
PF01081
(Aldolase)
3 ARG A 143
VAL A 177
GLY A 159
None
0.61A 2avvE-2yw4A:
undetectable
2avvE-2yw4A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcv UNCHARACTERIZED
OXIDOREDUCTASE YTFG


(Escherichia
coli)
PF05368
(NmrA)
3 ARG A 171
VAL A  77
GLY A 113
NDP  A 400 (-4.1A)
None
None
0.57A 2avvE-2zcvA:
undetectable
2avvE-2zcvA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfu CEREBRAL PROTEIN 1

(Homo sapiens)
PF05148
(Methyltransf_8)
3 ARG A 298
VAL A 415
GLY A 386
None
0.66A 2avvE-2zfuA:
undetectable
2avvE-2zfuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE


(Thermus
thermophilus)
PF05175
(MTS)
3 ARG A 163
VAL A 106
GLY A  57
None
0.53A 2avvE-2zwvA:
undetectable
2avvE-2zwvA:
14.63