SIMILAR PATTERNS OF AMINO ACIDS FOR 2AVV_E_MK1E902_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 ASP A 355
ILE A  49
VAL A  96
 None
 0.67A 2avvD-1a2vA:
0.0		 2avvD-1a2vA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		3 ASP A 174
ILE A  34
VAL A 282
 None
 0.68A 2avvD-1amyA:
undetectable		 2avvD-1amyA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b74 GLUTAMATE RACEMASE

(Aquifex
pyrophilus) 		PF01177
(Asp_Glu_race) 		3 ASP A  33
ILE A  48
VAL A  89
 None
 0.68A 2avvD-1b74A:
0.0		 2avvD-1b74A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ASP B 226
ILE A  37
VAL B 321
 None
 0.70A 2avvD-1bplB:
0.0		 2avvD-1bplB:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides) 		PF01266
(DAO) 		3 ASP A1036
ILE A1186
VAL A1008
 FAD  A1363 (-3.4A)
FAD  A1363 (-4.7A)
None
 0.59A 2avvD-1c0iA:
0.0		 2avvD-1c0iA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		3 ASP A 346
ILE A 447
VAL A 443
 None
 0.71A 2avvD-1c7tA:
0.0		 2avvD-1c7tA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7v CALCIUM VECTOR
PROTEIN

(Branchiostoma
lanceolatum) 		PF13499
(EF-hand_7) 		3 ASP A 124
ILE A 113
VAL A 141
 None
 0.65A 2avvD-1c7vA:
undetectable		 2avvD-1c7vA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cdo ALCOHOL
DEHYDROGENASE

(Gadus morhua) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASP A 337
ILE A 161
VAL A 177
 None
 0.62A 2avvD-1cdoA:
0.0		 2avvD-1cdoA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cov COXSACKIEVIRUS COAT
PROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		3 ASP 3  50
ILE 3 168
VAL 3  94
 None
 0.70A 2avvD-1cov3:
0.0		 2avvD-1cov3:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		3 ASP A 374
ILE A 105
VAL A 389
 None
 0.71A 2avvD-1d8cA:
undetectable		 2avvD-1d8cA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 ASP B 433
ILE B 145
VAL B 372
 None
 0.56A 2avvD-1e9yB:
undetectable		 2avvD-1e9yB:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg3 DYSTROPHIN

(Homo sapiens) 		PF00397
(WW)
PF09068
(EF-hand_2)
PF09069
(EF-hand_3) 		3 ASP A 187
ILE A  65
VAL A 175
 None
 0.66A 2avvD-1eg3A:
undetectable		 2avvD-1eg3A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehi D-ALANINE:D-LACTATE
LIGASE

(Leuconostoc
mesenteroides) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 ASP A  18
ILE A  68
VAL A  41
 None
 0.65A 2avvD-1ehiA:
undetectable		 2avvD-1ehiA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 ASP A  85
ILE A 252
VAL A 260
 None
None
C8E  A 456 ( 4.0A)
 0.54A 2avvD-1ethA:
undetectable		 2avvD-1ethA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		3 ASP A  26
ILE A  10
VAL A 105
 None
 0.68A 2avvD-1ex9A:
undetectable		 2avvD-1ex9A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gui LAMINARINASE 16A

(Thermotoga
maritima) 		PF02018
(CBM_4_9) 		3 ASP A  59
ILE A  91
VAL A  39
 None
 0.58A 2avvD-1guiA:
undetectable		 2avvD-1guiA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdf SPHERULIN 3A

(Physarum
polycephalum) 		PF08964
(Crystall_3) 		3 ASP A  81
ILE A  91
VAL A  52
 None
 0.68A 2avvD-1hdfA:
undetectable		 2avvD-1hdfA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 ASP O 323
ILE O 271
VAL O 217
 None
 0.58A 2avvD-1hdgO:
undetectable		 2avvD-1hdgO:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg8 ENDOPOLYGALACTURONAS
E

(Fusarium
verticillioides) 		PF00295
(Glyco_hydro_28) 		3 ASP A 191
ILE A 238
VAL A 201
 None
 0.68A 2avvD-1hg8A:
undetectable		 2avvD-1hg8A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv5 STROMELYSIN 3

(Mus musculus) 		PF00413
(Peptidase_M10) 		3 ASP A 194
ILE A 118
VAL A 216
 None
None
RXP  A6001 (-3.7A)
 0.71A 2avvD-1hv5A:
undetectable		 2avvD-1hv5A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		3 ASP A  62
ILE A  54
VAL A  84
 None
 0.64A 2avvD-1i8dA:
undetectable		 2avvD-1i8dA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia5 POLYGALACTURONASE

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		3 ASP A 159
ILE A 206
VAL A 169
 None
 0.69A 2avvD-1ia5A:
undetectable		 2avvD-1ia5A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		3 ASP A   7
ILE A 288
VAL A 278
 None
 0.71A 2avvD-1jjiA:
undetectable		 2avvD-1jjiA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME

(Homo sapiens) 		PF01536
(SAM_decarbox) 		3 ASP A 155
ILE A 179
VAL A 321
 None
 0.67A 2avvD-1jl0A:
undetectable		 2avvD-1jl0A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js4 ENDO/EXOCELLULASE E4

(Thermobifida
fusca) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		3 ASP A 170
ILE A  78
VAL A 179
 None
 0.63A 2avvD-1js4A:
undetectable		 2avvD-1js4A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		3 ASP A 168
ILE A  93
VAL A  97
 None
 0.70A 2avvD-1k32A:
undetectable		 2avvD-1k32A:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A  29
ILE A  35
VAL A 204
 None
 0.69A 2avvD-1kcwA:
undetectable		 2avvD-1kcwA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khh GUANIDINOACETATE
METHYLTRANSFERASE

(Rattus
norvegicus) 		no annotation 3 ASP A 134
ILE A 228
VAL A 232
 SAH  A 236 (-3.4A)
None
None
 0.63A 2avvD-1khhA:
undetectable		 2avvD-1khhA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkc MANGANESE SUPEROXIDE
DISMUTASE

(Aspergillus
fumigatus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ASP A 174
ILE A  86
VAL A 145
 MN  A2001 (-2.7A)
None
None
 0.47A 2avvD-1kkcA:
undetectable		 2avvD-1kkcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		3 ASP A 118
ILE A 287
VAL A 322
 None
None
ODP  A2458 ( 3.8A)
 0.66A 2avvD-1lqtA:
undetectable		 2avvD-1lqtA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6z CYTOCHROME C4

(Pseudomonas
stutzeri) 		PF00034
(Cytochrom_C) 		3 ASP A  75
ILE A  47
VAL A  11
 None
 0.60A 2avvD-1m6zA:
undetectable		 2avvD-1m6zA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ASP A 420
ILE A 349
VAL A 217
 None
 0.69A 2avvD-1mdfA:
undetectable		 2avvD-1mdfA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN CAPSID
PROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		3 ASP C  50
ILE C 168
VAL C  94
 None
 0.58A 2avvD-1mqtC:
undetectable		 2avvD-1mqtC:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf1 PROTEIN
(NEUROFIBROMIN)

(Homo sapiens) 		PF00616
(RasGAP) 		3 ASP A1516
ILE A1497
VAL A1212
 None
 0.67A 2avvD-1nf1A:
undetectable		 2avvD-1nf1A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		3 ASP A 186
ILE A 233
VAL A 196
 None
 0.66A 2avvD-1nhcA:
undetectable		 2avvD-1nhcA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhy ELONGATION FACTOR
1-GAMMA 1

(Saccharomyces
cerevisiae) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 ASP A 130
ILE A 115
VAL A 140
 None
 0.68A 2avvD-1nhyA:
undetectable		 2avvD-1nhyA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1noz DNA POLYMERASE

(Escherichia
virus T4) 		PF03104
(DNA_pol_B_exo1) 		3 ASP A 363
ILE A  91
VAL A 341
 None
 0.67A 2avvD-1nozA:
undetectable		 2avvD-1nozA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogo DEXTRANASE

(Talaromyces
minioluteus) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		3 ASP X 395
ILE X 421
VAL X 389
 GLC  X1576 (-2.7A)
None
None
 0.69A 2avvD-1ogoX:
undetectable		 2avvD-1ogoX:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p27 MAGO NASHI PROTEIN
HOMOLOG
RNA-BINDING PROTEIN
8A

(Homo sapiens) 		PF00076
(RRM_1)
PF02792
(Mago_nashi) 		3 ASP B 107
ILE A  64
VAL A 133
 None
 0.71A 2avvD-1p27B:
undetectable		 2avvD-1p27B:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q40 MRNA TRANSPORT
REGULATOR MTR2

(Candida
albicans) 		PF10429
(Mtr2) 		3 ASP A  66
ILE A 163
VAL A  54
 None
 0.52A 2avvD-1q40A:
undetectable		 2avvD-1q40A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 ASP A 405
ILE A 425
VAL A 388
 None
 0.58A 2avvD-1q5nA:
undetectable		 2avvD-1q5nA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 ASP A 151
ILE A 142
VAL A  69
 None
 0.69A 2avvD-1r6xA:
undetectable		 2avvD-1r6xA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxm DNA POLYMERASE
SLIDING CLAMP

(Archaeoglobus
fulgidus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 ASP A 209
ILE A  51
VAL A  47
 None
 0.67A 2avvD-1rxmA:
undetectable		 2avvD-1rxmA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE

(Archaeoglobus
fulgidus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 ASP A 147
ILE A 143
VAL A 165
 None
 0.66A 2avvD-1rxwA:
undetectable		 2avvD-1rxwA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 ASP B 492
ILE B 531
VAL B 521
 None
 0.56A 2avvD-1t3qB:
undetectable		 2avvD-1t3qB:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp9 PEROXIREDOXIN

(Populus
trichocarpa) 		PF08534
(Redoxin) 		3 ASP A 103
ILE A   4
VAL A  38
 None
 0.57A 2avvD-1tp9A:
undetectable		 2avvD-1tp9A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud3 AMYLASE

(Bacillus sp.
KSM-K38) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ASP A 328
ILE A 233
VAL A 321
 None
 0.61A 2avvD-1ud3A:
undetectable		 2avvD-1ud3A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujj ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1

(Homo sapiens) 		PF00790
(VHS) 		3 ASP A  40
ILE A  14
VAL A  85
 None
 0.62A 2avvD-1ujjA:
undetectable		 2avvD-1ujjA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ul1 FLAP ENDONUCLEASE-1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 ASP X 154
ILE X 150
VAL X 172
 None
 0.54A 2avvD-1ul1X:
undetectable		 2avvD-1ul1X:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upn ECHOVIRUS 11 COAT
PROTEIN VP3

(Enterovirus B) 		PF00073
(Rhv) 		3 ASP C  50
ILE C 168
VAL C  94
 None
 0.67A 2avvD-1upnC:
undetectable		 2avvD-1upnC:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		3 ASP A  35
ILE A  74
VAL A  66
 None
 0.66A 2avvD-1upxA:
undetectable		 2avvD-1upxA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 ASP A 624
ILE A 749
VAL A 745
 MG  A2000 ( 3.7A)
None
None
 0.70A 2avvD-1vbgA:
undetectable		 2avvD-1vbgA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ASP A 226
ILE A  37
VAL A 321
 None
 0.70A 2avvD-1vjsA:
undetectable		 2avvD-1vjsA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		3 ASP A 354
ILE A 389
VAL A 364
 None
 0.60A 2avvD-1vljA:
undetectable		 2avvD-1vljA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Thermotoga
maritima) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 ASP A 328
ILE A 444
VAL A 317
 None
 0.65A 2avvD-1vrdA:
undetectable		 2avvD-1vrdA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Thermotoga
maritima) 		PF01039
(Carboxyl_trans) 		3 ASP A 418
ILE A 346
VAL A 360
 None
 0.48A 2avvD-1vrgA:
undetectable		 2avvD-1vrgA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		3 ASP A 325
ILE A  12
VAL A 318
 None
 0.60A 2avvD-1wpwA:
undetectable		 2avvD-1wpwA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		3 ASP A 426
ILE A 354
VAL A 368
 None
 0.28A 2avvD-1x0uA:
undetectable		 2avvD-1x0uA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE

(Rattus
norvegicus) 		no annotation 3 ASP A 134
ILE A 228
VAL A 232
 NMG  A 237 ( 3.0A)
None
None
 0.71A 2avvD-1xcjA:
undetectable		 2avvD-1xcjA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		3 ASP A 308
ILE A  95
VAL A 555
 None
 0.69A 2avvD-1xl8A:
undetectable		 2avvD-1xl8A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II

(Sporidiobolus
salmonicolor) 		PF01370
(Epimerase) 		3 ASP A 311
ILE A 318
VAL A 248
 None
 0.67A 2avvD-1y1pA:
undetectable		 2avvD-1y1pA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj7 ESCJ

(Escherichia
coli) 		PF01514
(YscJ_FliF) 		3 ASP A 126
ILE A 114
VAL A 159
 None
 0.59A 2avvD-1yj7A:
undetectable		 2avvD-1yj7A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw1 PROTEIN YTNJ

(Bacillus
subtilis) 		PF00296
(Bac_luciferase) 		3 ASP A 391
ILE A 387
VAL A 400
 None
 0.70A 2avvD-1yw1A:
undetectable		 2avvD-1yw1A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyr TRICHODIENE SYNTHASE

(Fusarium
sporotrichioides) 		PF06330
(TRI5) 		3 ASP A 101
ILE A  70
VAL A 131
 None
 0.69A 2avvD-1yyrA:
undetectable		 2avvD-1yyrA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY

(Vibrio cholerae) 		PF00480
(ROK) 		3 ASP A 193
ILE A 218
VAL A 214
 SO4  A 408 ( 4.3A)
None
None
 0.69A 2avvD-1z05A:
undetectable		 2avvD-1z05A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		3 ASP A 207
ILE A 473
VAL A  29
 None
 0.54A 2avvD-1z45A:
undetectable		 2avvD-1z45A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		3 ASP A 115
ILE A  82
VAL A  29
 None
 0.70A 2avvD-1zapA:
7.0		 2avvD-1zapA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zo1 TRANSLATION
INITIATION FACTOR 2

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		3 ASP I 600
ILE I 611
VAL I 552
 None
 0.56A 2avvD-1zo1I:
undetectable		 2avvD-1zo1I:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A 146
ILE A 142
VAL A 234
 None
NAG  A2002 ( 4.8A)
None
 0.57A 2avvD-1zpuA:
undetectable		 2avvD-1zpuA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		3 ASP C 252
ILE C 213
VAL C  56
 None
 0.63A 2avvD-1zrtC:
undetectable		 2avvD-1zrtC:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zu4 FTSY

(Mycoplasma
mycoides) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		3 ASP A 190
ILE A 311
VAL A 202
 None
 0.51A 2avvD-1zu4A:
undetectable		 2avvD-1zu4A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bma GLUTAMATE
DEHYDROGENASE
(NADP+)

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 ASP A 261
ILE A 281
VAL A 256
 None
 0.60A 2avvD-2bmaA:
undetectable		 2avvD-2bmaA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1d SOXX

(Paracoccus
pantotrophus) 		PF00034
(Cytochrom_C) 		3 ASP B  88
ILE B  67
VAL B  99
 None
None
HEC  B1158 ( 4.6A)
 0.61A 2avvD-2c1dB:
undetectable		 2avvD-2c1dB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		3 ASP A 428
ILE A 544
VAL A 553
 None
 0.71A 2avvD-2c3oA:
undetectable		 2avvD-2c3oA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 ASP A 268
ILE A 230
VAL A 273
 None
 0.68A 2avvD-2cu0A:
undetectable		 2avvD-2cu0A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvh DNA REPAIR AND
RECOMBINATION
PROTEIN RADB

(Thermococcus
kodakarensis) 		PF08423
(Rad51) 		3 ASP A 178
ILE A 147
VAL A 111
 None
 0.65A 2avvD-2cvhA:
undetectable		 2avvD-2cvhA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dch PUTATIVE HOMING
ENDONUCLEASE

(Thermoproteus) 		PF14528
(LAGLIDADG_3) 		3 ASP X  14
ILE X 100
VAL X 109
 None
 0.59A 2avvD-2dchX:
undetectable		 2avvD-2dchX:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dch PUTATIVE HOMING
ENDONUCLEASE

(Thermoproteus) 		PF14528
(LAGLIDADG_3) 		3 ASP X  94
ILE X 139
VAL X  77
 SO4  X 302 ( 4.7A)
None
None
 0.52A 2avvD-2dchX:
undetectable		 2avvD-2dchX:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg0 DRP35

(Staphylococcus
aureus) 		PF08450
(SGL) 		3 ASP A 214
ILE A 178
VAL A 141
 None
 0.64A 2avvD-2dg0A:
undetectable		 2avvD-2dg0A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		3 ASP A 128
ILE A 179
VAL A 203
 None
 0.71A 2avvD-2dh3A:
undetectable		 2avvD-2dh3A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ASP A 231
ILE A  39
VAL A 326
 None
 0.68A 2avvD-2dieA:
undetectable		 2avvD-2dieA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 ASP A 327
ILE A  66
VAL A 294
 None
 0.64A 2avvD-2dkkA:
undetectable		 2avvD-2dkkA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4o PEPTIDE N-GLYCANASE

(Mus musculus) 		PF01841
(Transglut_core) 		3 ASP A 332
ILE A 168
VAL A 395
 None
 0.66A 2avvD-2f4oA:
undetectable		 2avvD-2f4oA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		3 ASP A 312
ILE A 301
VAL A 434
 NA  A 997 ( 4.9A)
PO4  A 900 (-4.6A)
None
 0.66A 2avvD-2f6dA:
undetectable		 2avvD-2f6dA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		3 ASP A  16
ILE A 142
VAL A 138
 NA  A3000 (-2.9A)
None
None
 0.70A 2avvD-2ftpA:
undetectable		 2avvD-2ftpA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		3 ASP A 731
ILE A 687
VAL A 739
 None
 0.68A 2avvD-2fuqA:
undetectable		 2avvD-2fuqA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		3 ASP A 317
ILE A 264
VAL A  55
 None
 0.69A 2avvD-2gouA:
undetectable		 2avvD-2gouA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gy7 ANGIOPOIETIN-2

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		3 ASP A 314
ILE A 373
VAL A 360
 None
 0.63A 2avvD-2gy7A:
undetectable		 2avvD-2gy7A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ha9 UPF0210 PROTEIN
SP0239

(Streptococcus
pneumoniae) 		PF05167
(DUF711) 		3 ASP A 163
ILE A 156
VAL A 395
 None
 0.57A 2avvD-2ha9A:
undetectable		 2avvD-2ha9A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwj HYPOTHETICAL PROTEIN
ATU1540

(Agrobacterium
fabrum) 		PF08857
(ParBc_2) 		3 ASP A  97
ILE A 124
VAL A  56
 None
 0.65A 2avvD-2hwjA:
undetectable		 2avvD-2hwjA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		3 ASP A 157
ILE A  18
VAL A  72
 None
 0.38A 2avvD-2i5gA:
undetectable		 2avvD-2i5gA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 ASP A 324
ILE A 206
VAL A 352
 None
 0.55A 2avvD-2ibuA:
undetectable		 2avvD-2ibuA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isn NYSGXRC-8828Z,
PHOSPHATASE

(Toxoplasma
gondii) 		PF00481
(PP2C) 		3 ASP A 286
ILE A 188
VAL A 327
 None
 0.58A 2avvD-2isnA:
undetectable		 2avvD-2isnA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		3 ASP A 422
ILE A 193
VAL A 132
 None
 0.65A 2avvD-2j3zA:
undetectable		 2avvD-2j3zA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)

(Homo sapiens) 		no annotation 3 ASP A 298
ILE A 229
VAL A 272
 None
 0.70A 2avvD-2jdxA:
undetectable		 2avvD-2jdxA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jft SER-THR PHOSPHATASE
MSPP

(Mycolicibacterium
smegmatis) 		PF13672
(PP2C_2) 		3 ASP A 127
ILE A 172
VAL A  33
 None
 0.70A 2avvD-2jftA:
undetectable		 2avvD-2jftA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		3 ASP A  71
ILE A   9
VAL A 155
 None
 0.70A 2avvD-2jkyA:
undetectable		 2avvD-2jkyA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4m UPF0146 PROTEIN
MTH_1000

(Methanothermobacter
thermautotrophicus) 		PF03686
(UPF0146) 		3 ASP A  61
ILE A  74
VAL A  50
 None
 0.70A 2avvD-2k4mA:
undetectable		 2avvD-2k4mA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4w SUPEROXIDE DISMUTASE
[CU-ZN]

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		3 ASP A  93
ILE A 127
VAL A 109
 ZN  A 156 (-1.6A)
None
None
 0.68A 2avvD-2k4wA:
undetectable		 2avvD-2k4wA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kg4 GROWTH ARREST AND
DNA-DAMAGE-INDUCIBLE
PROTEIN GADD45 ALPHA

(Homo sapiens) 		PF01248
(Ribosomal_L7Ae) 		3 ASP A  68
ILE A  78
VAL A  92
 None
 0.66A 2avvD-2kg4A:
undetectable		 2avvD-2kg4A:
18.52