SIMILAR PATTERNS OF AMINO ACIDS FOR 2AVO_B_MK1B902_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e5f | METHIONINEGAMMA-LYASE (Trichomonasvaginalis) |
PF01053(Cys_Met_Meta_PP) | 5 | LEU A 229ILE A 240ILE A 90VAL A 81ILE A 232 | None | 1.12A | 2avoA-1e5fA:undetectable | 2avoA-1e5fA:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fxl | PARANEOPLASTICENCEPHALOMYELITISANTIGEN HUD (Homo sapiens) |
PF00076(RRM_1) | 5 | LEU A 186GLY A 167ILE A 156VAL A 200ILE A 198 | None | 1.07A | 2avoA-1fxlA:undetectable | 2avoA-1fxlA:23.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ARG A 8LEU A 23ASP A 25ILE A 47VAL A 82 | A79 A 800 (-3.6A)A79 A 800 ( 4.0A)A79 A 800 (-2.8A)A79 A 800 ( 3.4A)A79 A 800 (-4.5A) | 0.84A | 2avoA-1hvcA:14.4 | 2avoA-1hvcA:46.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25ILE A 47GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | A79 A 800 ( 3.8A)A79 A 800 (-2.7A)A79 A 800 ( 3.2A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-4.5A)A79 A 800 (-3.6A) | 0.59A | 2avoA-1hvcA:14.4 | 2avoA-1hvcA:46.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25ILE A 47GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | A79 A 800 ( 4.0A)A79 A 800 (-2.8A)A79 A 800 ( 3.4A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A)A79 A 800 (-4.5A)A79 A 800 (-3.8A) | 0.66A | 2avoA-1hvcA:14.4 | 2avoA-1hvcA:46.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ibq | ASPERGILLOPEPSIN (Aspergillusphoenicis) |
PF00026(Asp) | 5 | LEU A 156ASP A 302ILE A 212GLY A 34VAL A 154 | NoneNoneNone ZN A1457 (-3.6A)None | 1.05A | 2avoA-1ibqA:6.3 | 2avoA-1ibqA:15.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1id8 | METHYLASPARTATEMUTASE S CHAIN (Clostridiumtetanomorphum) |
PF02310(B12-binding) | 5 | LEU A 88ILE A 37ILE A 69VAL A 90ILE A 58 | None | 0.98A | 2avoA-1id8A:undetectable | 2avoA-1id8A:26.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ize | ASPARTIC PROTEINASE (Aspergillusoryzae) |
PF00026(Asp) | 5 | LEU A 157ASP A 300ILE A 212GLY A 35VAL A 155 | None | 1.01A | 2avoA-1izeA:6.5 | 2avoA-1izeA:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqe | HISTAMINEN-METHYLTRANSFERASE (Homo sapiens) |
PF13489(Methyltransf_23) | 5 | LEU A 71ASP A 67ILE A 171ILE A 59ILE A 70 | None | 1.01A | 2avoA-1jqeA:undetectable | 2avoA-1jqeA:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k4y | LIVERCARBOXYLESTERASE (Oryctolaguscuniculus) |
PF00135(COesterase) | 5 | LEU A 475GLY A 223ILE A 139VAL A 474ILE A 471 | None | 1.10A | 2avoA-1k4yA:undetectable | 2avoA-1k4yA:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lk5 | D-RIBOSE-5-PHOSPHATEISOMERASE (Pyrococcushorikoshii) |
PF06026(Rib_5-P_isom_A) | 5 | LEU A 161ILE A 200GLY A 202ILE A 141ILE A 180 | None | 1.01A | 2avoA-1lk5A:undetectable | 2avoA-1lk5A:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o94 | TRIMETHYLAMINEDEHYDROGENASE (Methylophilusmethylotrophus) |
PF00724(Oxidored_FMN)PF07992(Pyr_redox_2) | 5 | LEU A 650GLY A 668ILE A 666VAL A 395ILE A 485 | ADP A1731 ( 4.6A)NoneNoneADP A1731 (-4.7A)None | 1.02A | 2avoA-1o94A:undetectable | 2avoA-1o94A:10.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1poi | GLUTACONATE COENZYMEA-TRANSFERASE (Acidaminococcusfermentans) |
PF01144(CoA_trans) | 5 | ILE B 21GLY B 37ILE B 36VAL B 53ILE B 51 | None | 0.98A | 2avoA-1poiB:undetectable | 2avoA-1poiB:16.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q90 | APOCYTOCHROME F (Chlamydomonasreinhardtii) |
PF01333(Apocytochr_F_C)PF16639(Apocytochr_F_N) | 5 | LEU A 83ILE A 244ILE A 76VAL A 128ILE A 130 | None | 1.05A | 2avoA-1q90A:undetectable | 2avoA-1q90A:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qrp | PEPSIN 3A (Homo sapiens) |
PF00026(Asp) | 5 | LEU E 155ASP E 303ILE E 213GLY E 34VAL E 153 | NoneNoneNoneHH0 E 327 (-4.1A)None | 1.01A | 2avoA-1qrpE:6.7 | 2avoA-1qrpE:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sd5 | PUTATIVEANTITERMINATOR (Mycobacteriumtuberculosis) |
PF00072(Response_reg)PF03861(ANTAR) | 5 | LEU A 61ILE A 25ILE A 118VAL A 16ILE A 63 | NoneIOD A 414 ( 4.4A)NoneNoneNone | 1.01A | 2avoA-1sd5A:undetectable | 2avoA-1sd5A:18.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 7 | ARG A 8LEU A 23ASP A 25GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.68A | 2avoA-1sivA:18.1 | 2avoA-1sivA:50.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sr8 | COBALAMINBIOSYNTHESIS PROTEIN(CBID) (Archaeoglobusfulgidus) |
PF01888(CbiD) | 5 | LEU A 243ASP A 240ILE A 260GLY A 263ILE A 239 | None | 1.12A | 2avoA-1sr8A:undetectable | 2avoA-1sr8A:15.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u3b | AMYLOID BETA A4PRECURSORPROTEIN-BINDING,FAMILY A, MEMBER 1 (Homo sapiens) |
PF00595(PDZ) | 5 | LEU A 101GLY A 67ILE A 66VAL A 21ILE A 103 | None | 1.08A | 2avoA-1u3bA:undetectable | 2avoA-1u3bA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2afv | COBALAMINBIOSYNTHESISPRECORRIN ISOMERASE (Leptospirainterrogans) |
PF02570(CbiC) | 5 | ILE A 194GLY A 165ILE A 139PRO A 160ILE A 136 | None | 0.91A | 2avoA-2afvA:undetectable | 2avoA-2afvA:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bty | ACETYLGLUTAMATEKINASE (Thermotogamaritima) |
PF00696(AA_kinase) | 5 | LEU A 199ILE A 213ILE A 225VAL A 252ILE A 254 | None | 1.04A | 2avoA-2btyA:undetectable | 2avoA-2btyA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bws | XAA-PROAMINOPEPTIDASE P (Escherichiacoli) |
PF00557(Peptidase_M24)PF05195(AMP_N) | 5 | LEU A 433ILE A 403ILE A 259VAL A 424ILE A 430 | None | 1.11A | 2avoA-2bwsA:undetectable | 2avoA-2bwsA:13.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1d | SOXASOXX (Paracoccusdenitrificans;Paracoccuspantotrophus) |
PF00034(Cytochrom_C)no annotation | 5 | ARG A 219GLY B 49ILE B 52VAL B 73ILE B 67 | None | 0.95A | 2avoA-2c1dA:undetectable | 2avoA-2c1dA:14.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cev | PROTEIN (ARGINASE) ([Bacillus]caldovelox) |
PF00491(Arginase) | 5 | LEU A 36GLY A 47ILE A 7VAL A 32ILE A 33 | None | 1.04A | 2avoA-2cevA:undetectable | 2avoA-2cevA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cev | PROTEIN (ARGINASE) ([Bacillus]caldovelox) |
PF00491(Arginase) | 5 | LEU A 46ILE A 101GLY A 104PRO A 92ILE A 7 | None | 1.10A | 2avoA-2cevA:undetectable | 2avoA-2cevA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cun | PHOSPHOGLYCERATEKINASE (Pyrococcushorikoshii) |
PF00162(PGK) | 5 | LEU A 316ILE A 376GLY A 357VAL A 343ILE A 347 | None | 0.81A | 2avoA-2cunA:undetectable | 2avoA-2cunA:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cv6 | SEED STORAGE PROTEIN (Vigna radiata) |
PF00190(Cupin_1) | 5 | LEU A 296ILE A 287ILE A 284VAL A 336ILE A 294 | None | 1.10A | 2avoA-2cv6A:undetectable | 2avoA-2cv6A:14.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e8y | AMYX PROTEIN (Bacillussubtilis) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | LEU A 36GLY A 88ILE A 87VAL A 75ILE A 18 | None | 1.10A | 2avoA-2e8yA:undetectable | 2avoA-2e8yA:8.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f2l | PEPTIDOGLYCAN-RECOGNITION PROTEIN-LCISOFORM LCA (Drosophilamelanogaster) |
PF01510(Amidase_2) | 5 | LEU A 403ASP A 407ILE A 370GLY A 438ILE A 416 | None | 1.09A | 2avoA-2f2lA:undetectable | 2avoA-2f2lA:18.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ASP A 25ILE A 53PRO A 86ILE A 89 | LP1 A 201 (-3.5A)NoneLP1 A 201 (-2.3A)LP1 A 201 (-4.6A)LP1 A 201 (-3.9A)LP1 A 201 (-4.2A) | 0.76A | 2avoA-2fmbA:14.8 | 2avoA-2fmbA:33.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ILE A 53GLY A 55PRO A 86VAL A 87ILE A 89 | NoneLP1 A 201 (-2.3A)LP1 A 201 (-4.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 ( 4.9A)LP1 A 201 (-4.2A) | 0.73A | 2avoA-2fmbA:14.8 | 2avoA-2fmbA:33.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gwr | DNA-BINDING RESPONSEREGULATOR MTRA (Mycobacteriumtuberculosis) |
PF00072(Response_reg)PF00486(Trans_reg_C) | 5 | ARG A 167LEU A 131ILE A 152VAL A 140ILE A 138 | GOL A2648 (-4.0A)NoneNoneNoneNone | 1.08A | 2avoA-2gwrA:undetectable | 2avoA-2gwrA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jir | PERIPLASMIC NITRATEREDUCTASE (Desulfovibriodesulfuricans) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 5 | LEU A 613ILE A 655ILE A 662VAL A 687ILE A 685 | None | 0.94A | 2avoA-2jirA:undetectable | 2avoA-2jirA:10.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lnv | GENERAL SECRETIONPATHWAY PROTEIN C (Dickeyadadantii) |
PF11356(T2SSC) | 5 | LEU A 145ILE A 110PRO A 129VAL A 128ILE A 135 | None | 0.97A | 2avoA-2lnvA:undetectable | 2avoA-2lnvA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nr7 | SECRETION ACTIVATORPROTEIN, PUTATIVE (Porphyromonasgingivalis) |
PF05838(Glyco_hydro_108)PF09374(PG_binding_3) | 5 | LEU A 134GLY A 102ILE A 103VAL A 87ILE A 138 | None | 0.81A | 2avoA-2nr7A:undetectable | 2avoA-2nr7A:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pcr | INOSITOL-1-MONOPHOSPHATASE (Aquifexaeolicus) |
PF00459(Inositol_P) | 5 | ARG A 82ILE A 221ILE A 215PRO A 113VAL A 108 | None | 1.11A | 2avoA-2pcrA:undetectable | 2avoA-2pcrA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q7x | UPF0052 PROTEINSP_1565 (Streptococcuspneumoniae) |
PF01933(UPF0052) | 5 | ARG A 300GLY A 192PRO A 16VAL A 17ILE A 18 | None | 1.11A | 2avoA-2q7xA:undetectable | 2avoA-2q7xA:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qde | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Aromatoleumaromaticum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 369ILE A 31GLY A 33VAL A 374ILE A 345 | None | 1.02A | 2avoA-2qdeA:undetectable | 2avoA-2qdeA:13.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8LEU A 23ASP A 25GLY A 49ILE A 50PRO A 81ILE A 84 | AB1 A 501 ( 4.7A)NoneAB1 A 501 (-2.4A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.70A | 2avoA-2rkfA:20.7 | 2avoA-2rkfA:81.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w20 | SIALIDASE A (Streptococcuspneumoniae) |
PF13088(BNR_2) | 5 | LEU A 536GLY A 613ILE A 585VAL A 558ILE A 554 | None | 0.94A | 2avoA-2w20A:undetectable | 2avoA-2w20A:12.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wed | PENICILLOPEPSIN (Penicilliumjanthinellum) |
PF00026(Asp) | 5 | LEU A 157ASP A 300ILE A 211GLY A 35VAL A 155 | NoneNoneNonePP6 A 327 (-4.0A)None | 0.99A | 2avoA-2wedA:7.4 | 2avoA-2wedA:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wfd | LEUCYL-TRNASYNTHETASE,CYTOPLASMIC (Homo sapiens) |
PF00133(tRNA-synt_1) | 5 | ILE A 287GLY A 315ILE A 314VAL A 307ILE A 357 | None | 1.00A | 2avoA-2wfdA:undetectable | 2avoA-2wfdA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y23 | MYOMESIN (Homo sapiens) |
PF07679(I-set) | 5 | ASP A1401GLY A1409ILE A1410VAL A1428ILE A1389 | None | 0.75A | 2avoA-2y23A:undetectable | 2avoA-2y23A:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zj4 | GLUCOSAMINE--FRUCTOSE-6-PHOSPHATEAMINOTRANSFERASE[ISOMERIZING] 1 (Homo sapiens) |
PF01380(SIS) | 5 | ILE A 634ILE A 592PRO A 615VAL A 588ILE A 589 | None | 1.07A | 2avoA-2zj4A:undetectable | 2avoA-2zj4A:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cdk | SUCCINYL-COA:3-KETOACID-COENZYME ATRANSFERASE SUBUNITB (Bacillussubtilis) |
PF01144(CoA_trans) | 5 | LEU B 44ILE B 67GLY B 70ILE B 26ILE B 53 | None | 1.06A | 2avoA-3cdkB:undetectable | 2avoA-3cdkB:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clj | PROTEIN NRD1 (Saccharomycescerevisiae) |
PF04818(CTD_bind) | 5 | LEU A 108GLY A 73ILE A 72VAL A 104ILE A 105 | None | 0.97A | 2avoA-3cljA:undetectable | 2avoA-3cljA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3euj | CHROMOSOME PARTITIONPROTEIN MUKB, LINKER ([Haemophilus]ducreyi) |
PF04310(MukB)PF13558(SbcCD_C) | 5 | LEU A1290GLY A1396ILE A1399VAL A1301ILE A1293 | None | 1.06A | 2avoA-3eujA:undetectable | 2avoA-3eujA:12.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i0m | DNA REPAIR ANDTELOMERE MAINTENANCEPROTEIN NBS1 (Schizosaccharomycespombe) |
PF00498(FHA) | 5 | ILE A 52GLY A 137ILE A 138VAL A 191ILE A 17 | None | 0.85A | 2avoA-3i0mA:undetectable | 2avoA-3i0mA:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lun | ULILYSIN (Methanosarcinaacetivorans) |
PF05572(Peptidase_M43) | 5 | LEU A 171GLY A 211ILE A 93VAL A 69ILE A 173 | None | 1.02A | 2avoA-3lunA:undetectable | 2avoA-3lunA:17.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | ARG A 8LEU A 23ASP A 25ILE A 47GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | None | 0.68A | 2avoA-3mwsA:19.4 | 2avoA-3mwsA:78.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nvs | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Vibrio cholerae) |
PF00275(EPSP_synthase) | 5 | ILE A 271GLY A 273ILE A 312VAL A 295ILE A 266 | None | 1.04A | 2avoA-3nvsA:undetectable | 2avoA-3nvsA:12.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ARG A 8ASP A 25ILE A 47GLY A 49ILE A 50 | SO4 A 101 (-3.8A)017 A 201 (-2.6A)None017 A 201 (-4.0A)017 A 201 (-3.3A) | 0.76A | 2avoA-3t3cA:18.7 | 2avoA-3t3cA:73.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | LEU A 23ASP A 25ILE A 47GLY A 49ILE A 50 | SO4 A 101 (-4.2A)017 A 201 (-2.6A)None017 A 201 (-4.0A)017 A 201 (-3.3A) | 0.48A | 2avoA-3t3cA:18.7 | 2avoA-3t3cA:73.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | LEU A 23ASP A 25ILE A 47GLY A 49PRO A 81 | SO4 A 101 (-4.2A)017 A 201 (-2.6A)None017 A 201 (-4.0A)None | 0.76A | 2avoA-3t3cA:18.7 | 2avoA-3t3cA:73.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8LEU A 23ASP A 25GLY A 49ILE A 50PRO A 81ILE A 84 | 017 A 201 ( 4.8A)None017 A 201 (-2.6A)017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.61A | 2avoA-3ttpA:19.2 | 2avoA-3ttpA:75.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8LEU A 23ASP A 25ILE A 47GLY A 49ILE A 50PRO A 81 | NoneNone017 A 202 ( 2.5A)017 A 202 (-3.6A)017 A 202 (-2.9A)017 A 201 ( 3.5A)017 A 202 (-4.0A) | 0.74A | 2avoA-3u7sA:19.8 | 2avoA-3u7sA:75.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vzq | ACETOACETYL-COAREDUCTASE (Cupriavidusnecator) |
PF00106(adh_short) | 5 | LEU A 199GLY A 184ILE A 186VAL A 203ILE A 202 | None | 1.10A | 2avoA-3vzqA:undetectable | 2avoA-3vzqA:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a9a | RIBOSOME-INTERACTINGGTPASE 1 (Saccharomycescerevisiae) |
PF01926(MMR_HSR1)PF02824(TGS)PF16897(MMR_HSR1_Xtn) | 5 | LEU A 145ILE A 122GLY A 72ILE A 149VAL A 68 | None | 0.95A | 2avoA-4a9aA:undetectable | 2avoA-4a9aA:15.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4avo | BETA-1,4-EXOCELLULASE (Thermobifidafusca) |
PF01341(Glyco_hydro_6) | 5 | LEU A 178GLY A 313ILE A 315VAL A 217ILE A 219 | None | 0.95A | 2avoA-4avoA:undetectable | 2avoA-4avoA:14.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4azw | WBDD (Escherichiacoli) |
PF00069(Pkinase)PF13847(Methyltransf_31) | 5 | LEU A 117GLY A 127ILE A 126VAL A 113ILE A 114 | None | 0.97A | 2avoA-4azwA:undetectable | 2avoA-4azwA:13.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4clc | UPF0303 PROTEINYBR137W (Saccharomycescerevisiae) |
PF03928(Haem_degrading) | 5 | LEU E 151ILE E 63GLY E 43VAL E 59ILE E 148 | None | 1.09A | 2avoA-4clcE:undetectable | 2avoA-4clcE:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ex9 | ALNA (Streptomycessp. CM020) |
PF04227(Indigoidine_A) | 5 | LEU A 9ILE A 87GLY A 108ILE A 110VAL A 68 | None | 0.93A | 2avoA-4ex9A:undetectable | 2avoA-4ex9A:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fe9 | OUTER MEMBRANEPROTEIN SUSF (Bacteroidesthetaiotaomicron) |
PF16411(SusF_SusE)PF17142(DUF5115) | 5 | LEU A 387ILE A 453GLY A 482VAL A 427ILE A 429 | None | 0.94A | 2avoA-4fe9A:undetectable | 2avoA-4fe9A:13.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fmz | INTERNALIN (Listeriamonocytogenes) |
PF12354(Internalin_N)PF12799(LRR_4)PF13855(LRR_8) | 5 | LEU A 343ILE A 356ILE A 310VAL A 339ILE A 340 | NoneEDO A 405 (-3.8A)NoneNoneNone | 0.89A | 2avoA-4fmzA:undetectable | 2avoA-4fmzA:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gt6 | CELL SURFACE PROTEIN (Faecalibacteriumprausnitzii) |
PF13306(LRR_5) | 5 | LEU A 148ILE A 80GLY A 105VAL A 151ILE A 147 | None | 1.11A | 2avoA-4gt6A:undetectable | 2avoA-4gt6A:13.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h0o | ACETATE KINASE (Entamoebahistolytica) |
PF00871(Acetate_kinase) | 5 | LEU A 183GLY A 208ILE A 195VAL A 179ILE A 180 | None | 0.87A | 2avoA-4h0oA:undetectable | 2avoA-4h0oA:13.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hci | CUPREDOXIN 1 (Bacillusanthracis) |
PF13473(Cupredoxin_1) | 5 | LEU A 69ILE A 127PRO A 56VAL A 47ILE A 45 | None | 1.10A | 2avoA-4hciA:undetectable | 2avoA-4hciA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jwy | GLUTAMATE RECEPTORIONOTROPIC, NMDA 2D (Rattusnorvegicus) |
PF10613(Lig_chan-Glu_bd) | 5 | LEU A 264ASP A 260ILE A 112GLY A 246ILE A 117 | None | 1.01A | 2avoA-4jwyA:undetectable | 2avoA-4jwyA:17.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mea | PREDICTED PROTEIN (Acinetobacternosocomialis) |
PF00561(Abhydrolase_1) | 5 | ILE A 66GLY A 141ILE A 140PRO A 117ILE A 114 | None | 1.10A | 2avoA-4meaA:undetectable | 2avoA-4meaA:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mk0 | BETA-ADRENERGICRECEPTOR KINASE 1 (Homo sapiens) |
PF00069(Pkinase)PF00169(PH)PF00615(RGS) | 5 | LEU A 279ILE A 254GLY A 304ILE A 302ILE A 323 | None | 1.08A | 2avoA-4mk0A:undetectable | 2avoA-4mk0A:10.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ASP A 25ILE A 47ILE A 50ILE A 84 | RIT A 500 (-3.2A)NoneRIT A 500 (-2.4A)RIT A 500 ( 4.5A)RIT A 500 (-4.3A)RIT A 500 (-4.3A) | 0.69A | 2avoA-4njvA:20.4 | 2avoA-4njvA:83.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | NoneRIT A 500 (-2.4A)RIT A 500 ( 4.5A)RIT A 500 (-3.4A)RIT A 500 (-4.3A)RIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.69A | 2avoA-4njvA:20.4 | 2avoA-4njvA:83.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pxq | D-GLUCURONYL C5EPIMERASE B (Danio rerio) |
PF06662(C5-epim_C) | 6 | LEU A 322ASP A 325GLY A 308ILE A 309VAL A 276ILE A 289 | None | 1.28A | 2avoA-4pxqA:undetectable | 2avoA-4pxqA:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q66 | PROTEIN BCH1 (Saccharomycescerevisiae) |
no annotation | 5 | LEU K 615ILE K 668ILE K 672VAL K 656ILE K 659 | None | 1.09A | 2avoA-4q66K:undetectable | 2avoA-4q66K:9.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4re2 | BETA-MANNOSIDASE/BETA-GLUCOSIDASE (Oryza sativa) |
PF00232(Glyco_hydro_1) | 5 | LEU A 438ILE A 410PRO A 466VAL A 455ILE A 454 | None | 1.09A | 2avoA-4re2A:undetectable | 2avoA-4re2A:11.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w7s | PRE-MRNA-SPLICINGATP-DEPENDENT RNAHELICASE PRP28 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | LEU A 359ILE A 294ILE A 259VAL A 362ILE A 358 | None | 1.07A | 2avoA-4w7sA:undetectable | 2avoA-4w7sA:14.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xcu | FIBROBLAST GROWTHFACTOR RECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A 526ILE A 628ILE A 609VAL A 523ILE A 527 | None | 0.96A | 2avoA-4xcuA:undetectable | 2avoA-4xcuA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xvx | ACYL-[ACYL-CARRIER-PROTEIN]DEHYDROGENASE MBTN (Mycobacteriumtuberculosis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | LEU A 93GLY A 119ILE A 161VAL A 220ILE A 92 | NoneFDA A 402 ( 4.2A)NoneNoneNone | 1.09A | 2avoA-4xvxA:undetectable | 2avoA-4xvxA:12.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 5 | ARG A 10LEU A 30ASP A 32GLY A 58ILE A 100 | NoneNone4B1 A 201 (-2.9A)4B1 A 201 (-3.4A)4B1 A 201 (-4.8A) | 0.72A | 2avoA-4ydfA:13.1 | 2avoA-4ydfA:31.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ywl | CELL DIVISIONCONTROL PROTEIN 21 (Pyrococcusfuriosus) |
PF14551(MCM_N)PF17207(MCM_OB) | 5 | ILE A 187GLY A 205ILE A 206VAL A 214ILE A 249 | None | 0.86A | 2avoA-4ywlA:undetectable | 2avoA-4ywlA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5awm | STRESS-ACTIVATEDPROTEIN KINASE JNK (Drosophilamelanogaster) |
PF00069(Pkinase) | 5 | LEU A 113ILE A 83GLY A 136VAL A 157ILE A 155 | None | 1.12A | 2avoA-5awmA:undetectable | 2avoA-5awmA:13.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5boe | ENOLASE (Staphylococcusaureus) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | ILE A 384ILE A 347PRO A 38VAL A 37ILE A 118 | None | 1.04A | 2avoA-5boeA:undetectable | 2avoA-5boeA:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cxu | FERULIC ACIDESTERASE AMCE1/FAE1A (Anaeromycesmucronatus) |
PF00756(Esterase) | 5 | ARG A 90LEU A 85ILE A 258PRO A 11ILE A 81 | None | 1.08A | 2avoA-5cxuA:undetectable | 2avoA-5cxuA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dlq | EXPORTIN-4 (Mus musculus) |
no annotation | 5 | LEU B 608ILE B 578ILE B 660VAL B 604ILE B 605 | None | 0.93A | 2avoA-5dlqB:undetectable | 2avoA-5dlqB:6.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h1k | GEM-ASSOCIATEDPROTEIN 5 (Homo sapiens) |
PF00400(WD40)PF12894(ANAPC4_WD40) | 5 | LEU A 147ILE A 175ILE A 178VAL A 134ILE A 149 | None | 1.11A | 2avoA-5h1kA:undetectable | 2avoA-5h1kA:8.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h42 | UNCHARACTERIZEDPROTEIN (Lachnoclostridiumphytofermentans) |
PF17167(Glyco_hydro_36) | 5 | LEU A 146GLY A 242ILE A 243VAL A 129ILE A 127 | None | 1.04A | 2avoA-5h42A:undetectable | 2avoA-5h42A:7.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikb | GLUTAMATE RECEPTORIONOTROPIC, KAINATE4,GLUTAMATE RECEPTORIONOTROPIC, KAINATE4 (Rattusnorvegicus) |
PF10613(Lig_chan-Glu_bd) | 5 | LEU A 235ASP A 231GLY A 217ILE A 91ILE A 234 | None | 1.00A | 2avoA-5ikbA:undetectable | 2avoA-5ikbA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mz9 | - (-) |
no annotation | 5 | LEU A 552GLY A 387ILE A 385VAL A 547ILE A 395 | None | 1.10A | 2avoA-5mz9A:undetectable | 2avoA-5mz9A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n7q | PUTATIVE CATHEPSIN D (Ixodes ricinus) |
no annotation | 5 | LEU A 160ASP A 316ILE A 225GLY A 38VAL A 158 | None | 0.93A | 2avoA-5n7qA:6.0 | 2avoA-5n7qA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n9m | COBYRIC ACIDSYNTHASE (Staphylococcusaureus) |
no annotation | 5 | LEU A 203ILE A 135GLY A 177ILE A 178ILE A 199 | None | 1.05A | 2avoA-5n9mA:undetectable | 2avoA-5n9mA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nr1 | FTSZ-BINDING PROTEINFZLA (Caulobactervibrioides) |
PF00043(GST_C)PF13417(GST_N_3) | 5 | LEU A 176GLY A 139PRO A 186VAL A 185ILE A 179 | None | 1.06A | 2avoA-5nr1A:undetectable | 2avoA-5nr1A:17.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5pep | PEPSIN (Sus scrofa) |
PF00026(Asp) | 5 | LEU A 155ASP A 304ILE A 213GLY A 34VAL A 153 | None | 1.09A | 2avoA-5pepA:6.7 | 2avoA-5pepA:18.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8LEU A 23ASP A 25ILE A 47ILE A 50PRO A 81ILE A 84 | None | 0.87A | 2avoA-5t2zA:19.7 | 2avoA-5t2zA:79.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ILE A 47GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.71A | 2avoA-5t2zA:19.7 | 2avoA-5t2zA:79.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5i | TUNGSTENFORMYLMETHANOFURANDEHYDROGENASESUBUNIT FWDG (Methanothermobacterwolfeii) |
PF12838(Fer4_7) | 5 | LEU G 60ILE G 76PRO G 23VAL G 24ILE G 45 | NoneSF4 G 101 ( 3.8A)NoneNoneSF4 G 102 ( 3.9A) | 1.06A | 2avoA-5t5iG:undetectable | 2avoA-5t5iG:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xir | HEAT SHOCK 70 KDAPROTEIN 1A (Homo sapiens) |
no annotation | 5 | LEU A 22ILE A 41GLY A 105PRO A 19ILE A 35 | None | 1.08A | 2avoA-5xirA:undetectable | 2avoA-5xirA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eki | CARBONIC ANHYDRASE (Persephonellamarina) |
no annotation | 5 | ARG A 247ILE A 152GLY A 150VAL A 63ILE A 65 | None | 0.92A | 2avoA-6ekiA:undetectable | 2avoA-6ekiA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en4 | SPLICING FACTOR 3BSUBUNIT 3 (Homo sapiens) |
no annotation | 5 | LEU A 6ILE A 412ILE A1092VAL A1112ILE A1110 | None | 0.92A | 2avoA-6en4A:undetectable | 2avoA-6en4A:22.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ASP A 25GLY A 49ILE A 50ILE A 84 | NoneNoneNIU A 100 (-2.8A)NIU A 100 ( 3.8A)NIU A 100 (-3.9A)None | 0.82A | 2avoA-6upjA:17.6 | 2avoA-6upjA:48.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 6 | LEU A 23ASP A 25GLY A 49ILE A 50PRO A 81ILE A 84 | NoneNIU A 100 (-2.8A)NIU A 100 ( 3.8A)NIU A 100 (-3.9A)NoneNone | 0.85A | 2avoA-6upjA:17.6 | 2avoA-6upjA:48.48 |