SIMILAR PATTERNS OF AMINO ACIDS FOR 2ARM_A_OINA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a2a PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		4 GLY A  30
HIS A  48
ASP A  49
TYR A  52
 None
 0.27A 2armA-1a2aA:
22.5		 2armA-1a2aA:
62.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a2a PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		4 GLY A  31
HIS A  48
ASP A  49
TYR A  52
 None
 0.89A 2armA-1a2aA:
22.5		 2armA-1a2aA:
62.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ae7 PHOSPHOLIPASE A2

(Notechis
scutatus) 		PF00068
(Phospholip_A2_1) 		4 GLY A  30
HIS A  48
ASP A  49
TYR A  52
 None
 0.51A 2armA-1ae7A:
16.2		 2armA-1ae7A:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aok VIPOXIN COMPLEX

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		6 GLY B  30
HIS B  48
ASP B  49
TYR B  52
PRO B  68
LYS B  69
 ACT  B 134 (-3.7A)
ACT  B 134 (-3.6A)
ACT  B 134 ( 4.9A)
None
None
None
 1.01A 2armA-1aokB:
20.8		 2armA-1aokB:
56.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE

(Arthrobacter
sp. 1C) 		PF02317
(Octopine_DH)
PF02558
(ApbA) 		4 HIS A 202
ASP A 297
TYR A 293
PRO A 286
 None
 1.03A 2armA-1bg6A:
undetectable		 2armA-1bg6A:
17.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpq PHOSPHOLIPASE A2

(Bos taurus) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  68
 CA  A 124 (-4.2A)
None
CA  A 124 (-2.1A)
None
None
 0.42A 2armA-1bpqA:
18.0		 2armA-1bpqA:
39.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpq PHOSPHOLIPASE A2

(Bos taurus) 		PF00068
(Phospholip_A2_1) 		4 GLY A  32
ASP A  49
TYR A  52
PRO A  68
 CA  A 124 (-4.2A)
CA  A 124 (-2.1A)
None
None
 1.12A 2armA-1bpqA:
18.0		 2armA-1bpqA:
39.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bun BETA2-BUNGAROTOXIN

(Bungarus
multicinctus) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  63
 NA  A 121 (-4.4A)
None
NA  A 121 (-2.6A)
None
None
 0.76A 2armA-1bunA:
17.3		 2armA-1bunA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bun BETA2-BUNGAROTOXIN

(Bungarus
multicinctus) 		PF00068
(Phospholip_A2_1) 		5 HIS A  48
ASP A  49
TYR A  52
PRO A  63
LYS A  64
 None
NA  A 121 (-2.6A)
None
None
None
 0.56A 2armA-1bunA:
17.3		 2armA-1bunA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dpy PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  63
 NA  A 150 (-4.5A)
None
NA  A 150 (-2.5A)
None
None
 0.71A 2armA-1dpyA:
17.3		 2armA-1dpyA:
39.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTM, FLAVOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 GLY C 180
TRP C 181
HIS C 211
PRO C 173
 None
 1.10A 2armA-1ffvC:
undetectable		 2armA-1ffvC:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fl5 ANTIBODY GERMLINE
PRECURSOR TO
ANTIBODY 28B4

(Homo sapiens) 		no annotation 4 GLY H  49
TRP H  36
ASP H  95
TYR H  33
 None
None
None
SO4  H 301 (-4.3A)
 1.20A 2armA-1fl5H:
undetectable		 2armA-1fl5H:
16.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g0z PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  63
 None
 0.79A 2armA-1g0zA:
17.1		 2armA-1g0zA:
39.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gmz PHOSPHOLIPASE A2

(Bothrops
pirajai) 		PF00068
(Phospholip_A2_1) 		4 HIS A  47
ASP A  48
TYR A  51
PRO A  59
 None
 0.36A 2armA-1gmzA:
20.1		 2armA-1gmzA:
64.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1god PROTEIN
(PHOSPHOLIPASE A2)

(Cerrophidion
godmani) 		PF00068
(Phospholip_A2_1) 		4 HIS A  48
TYR A  52
PRO A  68
LYS A  69
 None
 0.55A 2armA-1godA:
20.9		 2armA-1godA:
57.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gp7 PHOSPHOLIPASE A2

(Ophiophagus
hannah) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  68
 CA  A1125 (-4.5A)
None
CA  A1125 (-2.4A)
None
None
 0.64A 2armA-1gp7A:
16.9		 2armA-1gp7A:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 GLY A  84
ASP A 536
TYR A 595
PRO A 594
 None
 1.14A 2armA-1h39A:
undetectable		 2armA-1h39A:
10.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ijl PHOSPHOLIPASE A2

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		4 GLY A  29
HIS A  47
ASP A  48
TYR A  51
 CA  A 203 (-4.5A)
None
CA  A 203 (-2.6A)
None
 0.58A 2armA-1ijlA:
20.9		 2armA-1ijlA:
52.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ijl PHOSPHOLIPASE A2

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		5 GLY A  31
ASP A  48
TYR A  51
PRO A  59
LYS A  60
 CA  A 203 (-4.0A)
CA  A 203 (-2.6A)
None
None
None
 1.45A 2armA-1ijlA:
20.9		 2armA-1ijlA:
52.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ijl PHOSPHOLIPASE A2

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		5 HIS A  47
ASP A  48
TYR A  51
PRO A  59
LYS A  60
 None
CA  A 203 (-2.6A)
None
None
None
 0.89A 2armA-1ijlA:
20.9		 2armA-1ijlA:
52.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jia PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  68
 CA  A 134 (-4.5A)
None
CA  A 134 (-2.4A)
None
None
 0.71A 2armA-1jiaA:
22.1		 2armA-1jiaA:
61.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jia PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		4 GLY A  32
ASP A  49
TYR A  52
PRO A  68
 CA  A 134 (-4.2A)
CA  A 134 (-2.4A)
None
None
 1.19A 2armA-1jiaA:
22.1		 2armA-1jiaA:
61.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1d D-HYDANTOINASE

(Geobacillus
stearothermophilus) 		PF01979
(Amidohydro_1) 		4 GLY A 323
ASP A 414
TYR A 415
PRO A 340
 None
 1.19A 2armA-1k1dA:
undetectable		 2armA-1k1dA:
12.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m8r PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		4 GLY A  30
HIS A  48
ASP A  49
TYR A  52
 BU1  A1002 (-4.3A)
None
CD  A1001 (-2.4A)
None
 0.45A 2armA-1m8rA:
21.0		 2armA-1m8rA:
54.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m8r PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		4 GLY A  32
HIS A  48
TYR A  52
PRO A  68
 CD  A1001 (-3.9A)
None
None
None
 0.97A 2armA-1m8rA:
21.0		 2armA-1m8rA:
54.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m8r PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		4 HIS A  48
ASP A  49
TYR A  52
PRO A  68
 None
CD  A1001 (-2.4A)
None
None
 0.38A 2armA-1m8rA:
21.0		 2armA-1m8rA:
54.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m8t PHOSPHOLIPASE A2

(Ophiophagus
hannah) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  68
 CA  A1001 (-4.3A)
None
CA  A1001 (-2.1A)
None
None
 0.59A 2armA-1m8tA:
18.1		 2armA-1m8tA:
40.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh2 PHOSPHOLIPASE A2

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  63
 None
ACY  A 302 (-3.4A)
ACY  A 302 (-3.4A)
None
None
 0.65A 2armA-1mh2A:
18.1		 2armA-1mh2A:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh8 PHOSPHOLIPASE A2

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  63
 None
 0.62A 2armA-1mh8A:
18.6		 2armA-1mh8A:
38.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh8 PHOSPHOLIPASE A2

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		4 GLY A  31
ASP A  49
TYR A  28
PRO A  37
 None
 1.18A 2armA-1mh8A:
18.6		 2armA-1mh8A:
38.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLY B 701
HIS B 766
TYR B 386
PRO B 214
 None
 1.18A 2armA-1n60B:
undetectable		 2armA-1n60B:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 GLY A 321
ASP A 411
TYR A 412
PRO A 338
 None
 1.19A 2armA-1nfgA:
undetectable		 2armA-1nfgA:
15.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oz6 PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		4 GLY A  30
HIS A  48
ASP A  49
TYR A  52
 CA  A 134 (-4.9A)
None
CA  A 134 (-2.6A)
None
 0.74A 2armA-1oz6A:
20.7		 2armA-1oz6A:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oz6 PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		5 HIS A  48
ASP A  49
TYR A  52
PRO A  68
LYS A  69
 None
CA  A 134 (-2.6A)
None
None
None
 0.55A 2armA-1oz6A:
20.7		 2armA-1oz6A:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p7o PHOSPHOLIPASE A2

(Micropechis
ikaheca) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  68
 None
 0.50A 2armA-1p7oA:
18.1		 2armA-1p7oA:
38.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1po8 PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  63
 SHV  A 122 ( 3.7A)
SHV  A 122 (-4.1A)
NA  A 121 (-2.4A)
None
None
 0.70A 2armA-1po8A:
17.4		 2armA-1po8A:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1po8 PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		4 GLY A  32
HIS A  48
TYR A  52
PRO A  63
 NA  A 121 (-3.3A)
SHV  A 122 (-4.1A)
None
None
 1.00A 2armA-1po8A:
17.4		 2armA-1po8A:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2

(Crotalus atrox) 		no annotation 6 GLY R  30
HIS R  48
ASP R  49
TYR R  52
PRO R  68
LYS R  69
 None
 1.28A 2armA-1pp2R:
21.4		 2armA-1pp2R:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2

(Crotalus atrox) 		no annotation 6 GLY R  30
TRP R  31
HIS R  48
ASP R  49
TYR R  52
PRO R  68
 None
 1.42A 2armA-1pp2R:
21.4		 2armA-1pp2R:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1psh PHOSPHOLIPASE A2

(Naja naja) 		PF00068
(Phospholip_A2_1) 		4 GLY A  29
HIS A  47
ASP A  48
TYR A  51
 CA  A 120 (-4.4A)
None
CA  A 120 (-2.0A)
None
 0.67A 2armA-1pshA:
18.2		 2armA-1pshA:
38.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1psh PHOSPHOLIPASE A2

(Naja naja) 		PF00068
(Phospholip_A2_1) 		4 HIS A  47
ASP A  48
TYR A  51
PRO A  62
 None
CA  A 120 (-2.0A)
None
None
 0.31A 2armA-1pshA:
18.2		 2armA-1pshA:
38.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pwo PHOSPHOLIPASE A2

(Micropechis
ikaheca) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  68
 None
 0.73A 2armA-1pwoA:
17.6		 2armA-1pwoA:
36.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q6v PHOSPHOLIPASE A2
VRV-PL-VIIIA

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		4 GLY A  30
HIS A  48
TYR A  52
PRO A  68
 None
 0.24A 2armA-1q6vA:
25.3		 2armA-1q6vA:
95.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE

(Escherichia
coli) 		PF03411
(Peptidase_M74) 		4 GLY A 109
HIS A 209
ASP A  97
PRO A 138
 None
SO4  A 500 (-4.0A)
None
None
 1.14A 2armA-1u10A:
undetectable		 2armA-1u10A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE

(Escherichia
coli) 		PF03411
(Peptidase_M74) 		4 GLY A 109
HIS A 209
ASP A 120
PRO A 138
 None
SO4  A 500 (-4.0A)
ZN  A 400 (-2.2A)
None
 1.14A 2armA-1u10A:
undetectable		 2armA-1u10A:
17.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vap PHOSPHOLIPASE A2

(Agkistrodon
piscivorus) 		PF00068
(Phospholip_A2_1) 		6 GLY A  29
TRP A  30
HIS A  47
ASP A  48
TYR A  51
PRO A  59
 None
 0.72A 2armA-1vapA:
21.5		 2armA-1vapA:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vip PHOSPHOLIPASE A2

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
LYS A  69
 None
 1.16A 2armA-1vipA:
21.6		 2armA-1vipA:
57.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vip PHOSPHOLIPASE A2

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		5 HIS A  48
ASP A  49
TYR A  52
PRO A  68
LYS A  69
 None
 0.99A 2armA-1vipA:
21.6		 2armA-1vipA:
57.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vpi PHOSPHOLIPASE A2
INHIBITOR

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
ASP A  49
TYR A  52
PRO A  68
LYS A  69
 None
 0.99A 2armA-1vpiA:
21.3		 2armA-1vpiA:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y75 PHOSPHOLIPASE A2
ISOFORM 6

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		5 GLY B  30
HIS B  48
ASP B  49
TYR B  52
PRO B  63
 None
 0.74A 2armA-1y75B:
17.9		 2armA-1y75B:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zl7 HYPOTENSIVE
PHOSPHOLIPASE A2

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		5 GLY A  29
ASP A  48
TYR A  51
PRO A  59
LYS A  60
 None
CA  A1001 ( 2.3A)
None
None
None
 0.96A 2armA-1zl7A:
19.6		 2armA-1zl7A:
53.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zl7 HYPOTENSIVE
PHOSPHOLIPASE A2

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		5 HIS A  47
ASP A  48
TYR A  51
PRO A  59
LYS A  60
 None
CA  A1001 ( 2.3A)
None
None
None
 0.61A 2armA-1zl7A:
19.6		 2armA-1zl7A:
53.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ask ARTEMIN

(Homo sapiens) 		PF00019
(TGF_beta) 		4 GLY A 113
HIS A  54
ASP A  55
PRO A  75
 None
 1.17A 2armA-2askA:
undetectable		 2armA-2askA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0y PROCATHEPSIN S

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 GLY A  61
HIS A  47
ASP A  59
TYR A  58
 None
 1.16A 2armA-2c0yA:
undetectable		 2armA-2c0yA:
17.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h4c PHOSPHOLIPASE A2-II

(Daboia
siamensis) 		PF00068
(Phospholip_A2_1) 		5 GLY B  30
HIS B  48
ASP B  49
TYR B  52
PRO B  68
 None
 0.73A 2armA-2h4cB:
19.1		 2armA-2h4cB:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h4c PHOSPHOLIPASE A2-II

(Daboia
siamensis) 		PF00068
(Phospholip_A2_1) 		4 HIS B  48
TYR B  52
PRO B  68
LYS B  69
 None
 1.16A 2armA-2h4cB:
19.1		 2armA-2h4cB:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h4c PHOSPHOLIPASE A2-III

(Daboia
siamensis) 		PF00068
(Phospholip_A2_1) 		5 HIS A  48
ASP A  49
TYR A  52
PRO A  68
LYS A  69
 None
 0.90A 2armA-2h4cA:
20.1		 2armA-2h4cA:
55.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0s AROMATIC AMINE
DEHYDROGENASE

(Alcaligenes
faecalis) 		PF06433
(Me-amine-dh_H) 		4 GLY A 327
HIS A 353
TYR A 291
PRO A 274
 None
 1.12A 2armA-2i0sA:
undetectable		 2armA-2i0sA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4w SUPEROXIDE DISMUTASE
[CU-ZN]

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		4 GLY A  71
HIS A  73
ASP A  75
PRO A 140
 None
ZN  A 156 ( 3.2A)
None
None
 1.16A 2armA-2k4wA:
undetectable		 2armA-2k4wA:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2osn PHOSPHOLIPASE A2
ISOFORM 3

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  63
 None
 0.99A 2armA-2osnA:
17.1		 2armA-2osnA:
36.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ph4 ZHAOERMIATOXIN

(Protobothrops
mangshanensis) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
TYR A  52
PRO A  68
LYS A  69
 PEG  A 401 ( 4.5A)
PEG  A 401 ( 4.9A)
None
None
None
 0.66A 2armA-2ph4A:
19.4		 2armA-2ph4A:
55.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		4 GLY A  30
HIS A  48
TYR A  52
PRO A  68
 None
 0.39A 2armA-2qheA:
22.5		 2armA-2qheA:
66.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		4 GLY A  31
HIS A  48
TYR A  52
PRO A  68
 None
 0.72A 2armA-2qheA:
22.5		 2armA-2qheA:
66.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8d AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 1

(Homo sapiens) 		PF00640
(PID) 		4 GLY A 414
TRP A 416
HIS A 409
ASP A 410
 None
 1.13A 2armA-3d8dA:
undetectable		 2armA-3d8dA:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dih PHOSPHOLIPASE A2
HOMOLOG, AMMODYTIN L

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 GLY A  29
HIS A  47
TYR A  51
PRO A  59
 None
 0.43A 2armA-3dihA:
22.4		 2armA-3dihA:
65.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dih PHOSPHOLIPASE A2
HOMOLOG, AMMODYTIN L

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 HIS A  47
TYR A  51
PRO A  59
LYS A  60
 None
 0.77A 2armA-3dihA:
22.4		 2armA-3dihA:
65.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		5 GLY A1200
TRP A 654
HIS A 854
TYR A1210
PRO A 228
 None
 1.47A 2armA-3egwA:
undetectable		 2armA-3egwA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		4 GLY A 380
HIS A 276
TYR A 277
PRO A 237
 None
 1.20A 2armA-3fcrA:
undetectable		 2armA-3fcrA:
12.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8g PHOSPHOLIPASE A2,
AMMODYTOXIN A

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 HIS A  47
ASP A  48
TYR A  51
PRO A  59
 None
 0.36A 2armA-3g8gA:
22.2		 2armA-3g8gA:
80.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8g PHOSPHOLIPASE A2,
AMMODYTOXIN A

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 HIS A  47
TYR A  51
PRO A  59
LYS A  60
 None
 0.86A 2armA-3g8gA:
22.2		 2armA-3g8gA:
80.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 GLY A 300
HIS A  85
ASP A 297
TYR A 328
 CA  A 603 (-4.3A)
None
CA  A 603 (-3.4A)
None
 1.10A 2armA-3hjrA:
undetectable		 2armA-3hjrA:
9.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p2p PHOSPHOLIPASE A2

(Sus scrofa) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  68
 CA  A 125 (-4.3A)
None
CA  A 125 (-2.1A)
None
None
 0.54A 2armA-3p2pA:
18.1		 2armA-3p2pA:
41.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 GLY A1177
ASP A  69
PRO A  77
LYS A  76
 None
 1.12A 2armA-3pieA:
undetectable		 2armA-3pieA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sut BETA-HEXOSAMINIDASE

(Paenibacillus
sp. TS12) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 GLY A 360
ASP A 332
TYR A 331
PRO A 256
 None
 0.88A 2armA-3sutA:
undetectable		 2armA-3sutA:
11.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9m PHOSPHOLIPASE A2
ISOZYME PA-11

(Pseudechis
australis) 		PF00068
(Phospholip_A2_1) 		6 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  62
LYS A  63
 EDO  A 201 (-3.5A)
EDO  A 201 ( 4.0A)
CA  A 205 (-2.2A)
EDO  A 201 ( 4.8A)
None
PEG  A 206 (-2.2A)
 0.66A 2armA-3v9mA:
17.9		 2armA-3v9mA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vbz PHOSPHOLIPASE A2
HOMOLOG, TAIPOXIN
BETA CHAIN

(Oxyuranus
scutellatus) 		PF00068
(Phospholip_A2_1) 		4 HIS A  48
ASP A  49
TYR A  52
PRO A  62
 None
 0.52A 2armA-3vbzA:
17.8		 2armA-3vbzA:
36.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		4 GLY A 130
HIS A 257
ASP A 258
TYR A 317
 None
 1.14A 2armA-3vsvA:
undetectable		 2armA-3vsvA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Sphingopyxis
sp. 113P3) 		no annotation 4 GLY A  49
TRP A 108
HIS A 279
TYR A 251
 SO4  A 901 ( 3.7A)
None
SO4  A 901 ( 4.4A)
None
 1.17A 2armA-3wlaA:
undetectable		 2armA-3wlaA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aef NEOPULLULANASE
(ALPHA-AMYLASE II)

(Pyrococcus
furiosus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16561
(AMPK1_CBM) 		4 GLY A 123
HIS A 126
TYR A 119
PRO A 489
 None
 1.19A 2armA-4aefA:
undetectable		 2armA-4aefA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbw SIALIDASE
(NEURAMINIDASE)

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		4 GLY A 269
TRP A 290
ASP A 235
PRO A 273
 None
 1.01A 2armA-4bbwA:
undetectable		 2armA-4bbwA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE

(Parabacteroides
distasonis) 		PF13859
(BNR_3)
PF14873
(BNR_assoc_N) 		4 GLY A 265
TRP A 286
ASP A 231
PRO A 269
 None
 1.02A 2armA-4fj6A:
undetectable		 2armA-4fj6A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcm THIOREDOXIN
REDUCTASE

(Staphylococcus
aureus) 		PF07992
(Pyr_redox_2) 		4 GLY A 282
ASP A 280
TYR A 258
PRO A 242
 None
 1.10A 2armA-4gcmA:
undetectable		 2armA-4gcmA:
15.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h0s BASIC PHOSPHOLIPASE
A2 HOMOLOG CTS-R6

(Trimeresurus
stejnegeri) 		PF00068
(Phospholip_A2_1) 		4 GLY A  30
HIS A  48
TYR A  52
LYS A  69
 None
 1.01A 2armA-4h0sA:
20.5		 2armA-4h0sA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6k BNR/ASP-BOX REPEAT
PROTEIN

(Bacteroides
caccae) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		4 GLY A 285
TRP A 306
ASP A 251
PRO A 289
 None
 0.99A 2armA-4q6kA:
undetectable		 2armA-4q6kA:
13.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rfp ACIDIC PHOSPHOLIPASE
A2 5

(Trimeresurus
stejnegeri) 		PF00068
(Phospholip_A2_1) 		4 HIS A  47
ASP A  48
TYR A  51
PRO A  59
 None
 0.45A 2armA-4rfpA:
20.1		 2armA-4rfpA:
53.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wtb BASIC PHOSPHOLIPASE
A2 HOMOLOG
BOTHROPSTOXIN-1

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		4 GLY A  29
HIS A  47
TYR A  51
PRO A  59
 None
ZN  A 201 (-3.1A)
None
None
 0.47A 2armA-4wtbA:
21.3		 2armA-4wtbA:
55.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egn ESTERASE

(uncultured
bacterium) 		PF12697
(Abhydrolase_6) 		4 GLY A  33
TRP A  35
ASP A  52
TYR A  12
 None
 1.04A 2armA-5egnA:
undetectable		 2armA-5egnA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 GLY A 888
TRP A 965
TYR A 892
PRO A 880
 None
 1.02A 2armA-5ihrA:
undetectable		 2armA-5ihrA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owc -

(-) 		no annotation 6 GLY A  28
HIS A  46
ASP A  47
TYR A  50
PRO A  60
LYS A  61
 AYZ  A 202 ( 3.5A)
AYZ  A 202 (-4.0A)
CA  A 201 ( 2.2A)
AYZ  A 202 ( 4.9A)
None
None
 0.59A 2armA-5owcA:
19.4		 2armA-5owcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swj PROBABLE ATP
SYNTHASE SPAL/MXIB

(Shigella
flexneri) 		PF00006
(ATP-synt_ab) 		4 GLY A 190
ASP A 217
TYR A 218
PRO A  98
 None
 0.96A 2armA-5swjA:
undetectable		 2armA-5swjA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tfv BASIC PHOSPHOLIPASE
A2 MYOTOXIN III

(Bothrops asper) 		PF00068
(Phospholip_A2_1) 		4 HIS A  48
ASP A  49
TYR A  52
PRO A  68
 None
 0.88A 2armA-5tfvA:
20.8		 2armA-5tfvA:
68.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tfv BASIC PHOSPHOLIPASE
A2 MYOTOXIN III

(Bothrops asper) 		PF00068
(Phospholip_A2_1) 		4 HIS A  48
TYR A  52
PRO A  68
LYS A  69
 None
 0.63A 2armA-5tfvA:
20.8		 2armA-5tfvA:
68.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txw PEPTIDASE

(Thermococcus
thioreducens) 		PF01965
(DJ-1_PfpI) 		4 GLY A  10
HIS A  44
ASP A  13
PRO A 151
 None
 1.14A 2armA-5txwA:
undetectable		 2armA-5txwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 4 GLY A 369
HIS A 231
PRO A 171
LYS A 170
 None
 1.12A 2armA-5ww1A:
undetectable		 2armA-5ww1A:
14.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wzm GROUP IIE SECRETORY
PHOSPHOLIPASE A2

(Homo sapiens) 		no annotation 6 GLY A  28
HIS A  46
ASP A  47
TYR A  50
PRO A  60
LYS A  61
 CA  A 210 (-4.3A)
None
CA  A 210 (-2.2A)
None
CL  A 201 (-3.7A)
CL  A 201 (-4.0A)
 1.05A 2armA-5wzmA:
20.3		 2armA-5wzmA:
34.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8z PENICILLIN V
ACYLASE-LIKE PROTEIN

(Shewanella
loihica) 		no annotation 4 GLY A 221
HIS A 198
ASP A 192
LYS A   1
 None
 1.18A 2armA-5x8zA:
undetectable		 2armA-5x8zA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y51 -

(-) 		no annotation 4 GLY A  47
HIS A  41
TYR A  57
PRO A 178
 None
 1.18A 2armA-5y51A:
undetectable		 2armA-5y51A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9r HYDROXYETHYLPHOSPHON
ATE DIOXYGENASE

(Streptomyces
albus) 		no annotation 4 GLY A 335
HIS A 339
TYR A 152
PRO A 186
 None
 1.11A 2armA-6b9rA:
undetectable		 2armA-6b9rA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ce2 -

(-) 		no annotation 4 GLY A  30
HIS A  48
TYR A  52
PRO A  68
 PE4  A 201 ( 3.6A)
None
None
None
 0.34A 2armA-6ce2A:
21.1		 2armA-6ce2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE

(Schizosaccharomyces
pombe) 		no annotation 4 GLY A  15
HIS A  50
TYR A  21
PRO A 289
 SAH  A 401 (-3.4A)
None
None
None
 0.98A 2armA-6fdfA:
undetectable		 2armA-6fdfA:
22.31