SIMILAR PATTERNS OF AMINO ACIDS FOR 2AOU_A_CQAA403_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF02463
(SMC_N) 		4 ASP A  42
GLY A  49
ASP A 129
THR A 124
 None
 1.04A 2aouA-1e69A:
undetectable		 2aouA-1e69A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 ASP A 107
GLY A 572
PHE A  52
ASP A  54
 None
 1.02A 2aouA-1flgA:
undetectable		 2aouA-1flgA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 TRP A 558
GLY A 498
ASP A 447
TYR A 495
 None
 0.94A 2aouA-1h39A:
undetectable		 2aouA-1h39A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iom CITRATE SYNTHASE

(Thermus
thermophilus) 		PF00285
(Citrate_synt) 		4 ASP A 123
LYS A 127
PHE A  43
THR A  46
 None
 0.93A 2aouA-1iomA:
undetectable		 2aouA-1iomA:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jqe HISTAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF13489
(Methyltransf_23) 		6 ASP A 180
TRP A 183
LYS A 184
GLY A 187
PHE A 190
THR A 247
 None
QUN  A 500 (-4.9A)
None
None
None
None
 1.07A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jqe HISTAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF13489
(Methyltransf_23) 		6 ASP A 180
TRP A 183
LYS A 184
PHE A 190
TYR A 198
THR A 247
 None
QUN  A 500 (-4.9A)
None
None
None
None
 1.09A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jqe HISTAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF13489
(Methyltransf_23) 		5 TRP A 183
LYS A 181
PHE A 190
TYR A 198
THR A 247
 QUN  A 500 (-4.9A)
None
None
None
None
 1.25A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js4 ENDO/EXOCELLULASE E4

(Thermobifida
fusca) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		4 ASP A 151
GLY A  63
TYR A 206
THR A 427
 None
 1.05A 2aouA-1js4A:
undetectable		 2aouA-1js4A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkh MEVALONATE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ASP A 139
LYS A 143
GLY A 145
THR A  10
 None
 1.00A 2aouA-1kkhA:
undetectable		 2aouA-1kkhA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqv CYTOCHROME C'

(Rhodopseudomonas
palustris) 		PF01322
(Cytochrom_C_2) 		4 ASP A 118
LYS A 114
PHE A  82
ASP A  80
 None
None
HEM  A 150 (-3.4A)
None
 0.93A 2aouA-1mqvA:
undetectable		 2aouA-1mqvA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 ASP A 570
GLY A 556
ASP A 560
THR A 638
 None
 0.98A 2aouA-1n76A:
undetectable		 2aouA-1n76A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pou OCT-1

(Homo sapiens) 		PF00157
(Pou) 		4 ASP A  73
TRP A  70
GLY A  35
THR A  46
 None
 0.99A 2aouA-1pouA:
undetectable		 2aouA-1pouA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpa LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 ASP A  23
LYS A 100
GLY A 102
ASP A 107
 None
 1.00A 2aouA-1qpaA:
undetectable		 2aouA-1qpaA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qsp YPD1

(Saccharomyces
cerevisiae) 		PF01627
(Hpt) 		4 ASP A 120
LYS A 153
PHE A  35
ASP A  37
 None
 0.99A 2aouA-1qspA:
undetectable		 2aouA-1qspA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)
RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (SMALL CHAIN)

(Synechococcus
elongatus;
Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
no annotation 		4 ASP A 396
GLY M 103
PHE M 104
TYR A 165
 None
 1.05A 2aouA-1rblA:
undetectable		 2aouA-1rblA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum) 		PF00150
(Cellulase) 		4 ASP A 158
GLY A 139
PHE A  90
TYR A 144
 None
 0.97A 2aouA-1rh9A:
undetectable		 2aouA-1rh9A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ASP A 388
GLY A 376
ASP A 427
THR A 423
 None
 0.93A 2aouA-1v7vA:
undetectable		 2aouA-1v7vA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg8 HYPOTHETICAL PROTEIN
SA0798

(Staphylococcus
aureus) 		PF07315
(DUF1462) 		4 ASP A  21
GLY A   5
ASP A  83
THR A  75
 None
 0.97A 2aouA-1xg8A:
undetectable		 2aouA-1xg8A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE

(Spinacia
oleracea) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 GLY I 231
PHE I 228
ASP I 315
THR I 520
 None
None
MG  I 602 (-2.7A)
None
 0.86A 2aouA-1yveI:
4.2		 2aouA-1yveI:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2c SPERMIDINE SYNTHASE

(Caenorhabditis
elegans) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 TRP A  43
GLY A  45
ASP A  16
THR A  10
 None
 1.05A 2aouA-2b2cA:
11.2		 2aouA-2b2cA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d04 CURCULIN

(Molineria
latifolia) 		PF01453
(B_lectin) 		4 ASP B  46
LYS B  28
GLY B  51
THR B  55
 None
 1.05A 2aouA-2d04B:
undetectable		 2aouA-2d04B:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Gallus gallus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ASP A 298
GLY A 131
PHE A 130
THR A 265
 None
None
None
TEO  A1002 (-3.7A)
 0.99A 2aouA-2h88A:
undetectable		 2aouA-2h88A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imz ENDONUCLEASE PI-MTUI

(Mycobacterium
tuberculosis) 		no annotation 4 ASP A  55
GLY A  52
PHE A 421
ASP A 422
 None
 1.05A 2aouA-2imzA:
undetectable		 2aouA-2imzA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpb BA42

(Bizionia
argentinensis) 		PF04536
(TPM_phosphatase) 		4 ASP A  81
PHE A  92
ASP A  90
THR A  95
 None
 0.82A 2aouA-2mpbA:
undetectable		 2aouA-2mpbA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		4 ASP A  34
PHE A  50
ASP A  54
THR A  59
 None
 0.96A 2aouA-2nx4A:
undetectable		 2aouA-2nx4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP A 217
LYS A 221
GLY A 186
THR A 161
 None
 1.03A 2aouA-2oq5A:
undetectable		 2aouA-2oq5A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owy RECOMBINATION-ASSOCI
ATED PROTEIN RDGC

(Pseudomonas
aeruginosa) 		PF04381
(RdgC) 		4 ASP A  20
LYS A  24
GLY A  27
PHE A  44
 None
 1.03A 2aouA-2owyA:
undetectable		 2aouA-2owyA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmx PREPHENATE
DEHYDRATASE

(Chlorobaculum
tepidum) 		PF00800
(PDT) 		4 ASP A  45
LYS A   3
GLY A  24
THR A  77
 None
 0.78A 2aouA-2qmxA:
undetectable		 2aouA-2qmxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN LIGHT CHAIN
3, SKELETAL MUSCLE
ISOFORM
MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT

(Gallus gallus;
Gallus gallus) 		no annotation
PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 LYS M 742
PHE M 720
ASP C  95
TYR C 139
 None
 0.93A 2aouA-2w4gM:
undetectable		 2aouA-2w4gM:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ASP A 281
GLY A 669
PHE A 664
TYR A 667
 None
 1.04A 2aouA-2wtbA:
5.9		 2aouA-2wtbA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ASP A 287
GLY A 120
PHE A 119
THR A 254
 None
None
None
TEO  A1589 (-3.8A)
 0.96A 2aouA-2wu5A:
undetectable		 2aouA-2wu5A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN

(Streptomyces
coelicolor) 		PF01497
(Peripla_BP_2) 		4 TRP A 122
GLY A  94
PHE A  75
THR A 141
 None
 0.99A 2aouA-2x4lA:
undetectable		 2aouA-2x4lA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 ASP A 315
LYS A 321
PHE A 324
ASP A 309
 None
 0.94A 2aouA-2xr1A:
undetectable		 2aouA-2xr1A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 ASP A 818
TRP A 821
LYS A 822
GLY A 825
 None
 0.86A 2aouA-2y3aA:
undetectable		 2aouA-2y3aA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 ASP B 582
LYS B 297
GLY B 299
THR B 304
 None
 1.05A 2aouA-2z2mB:
undetectable		 2aouA-2z2mB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		4 ASP A 398
LYS A 396
GLY A 408
THR A 451
 None
 1.03A 2aouA-3afgA:
undetectable		 2aouA-3afgA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		4 GLY A 859
PHE A 860
ASP A 665
TYR A 658
 None
 1.01A 2aouA-3aibA:
undetectable		 2aouA-3aibA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Mus musculus) 		PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind) 		4 ASP A 259
GLY A 130
PHE A  93
TYR A 133
 None
 1.01A 2aouA-3d45A:
undetectable		 2aouA-3d45A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddu PROLYL ENDOPEPTIDASE

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 ASP A 582
GLY A 592
ASP A 598
TYR A 599
 None
 0.97A 2aouA-3dduA:
2.6		 2aouA-3dduA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euk CHROMOSOME PARTITION
PROTEIN MUKF

([Haemophilus]
ducreyi) 		PF17193
(MukF_C) 		4 ASP E 404
LYS E 408
GLY E 410
ASP E 415
 None
 0.93A 2aouA-3eukE:
undetectable		 2aouA-3eukE:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)

(Oryza sativa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 GLY A 231
PHE A 228
ASP A 315
THR A 520
 None
None
MG  A   1 ( 3.5A)
None
 0.93A 2aouA-3fr8A:
undetectable		 2aouA-3fr8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g12 PUTATIVE
LACTOYLGLUTATHIONE
LYASE

(Bdellovibrio
bacteriovorus) 		no annotation 4 GLY A  20
ASP A 107
TYR A  22
THR A  12
 None
 1.00A 2aouA-3g12A:
undetectable		 2aouA-3g12A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyi FAT ACID-BINDING
PROTEIN

(Eubacterium
ventriosum) 		PF02645
(DegV) 		4 ASP A  21
LYS A   3
PHE A  87
ASP A   7
 None
 0.95A 2aouA-3nyiA:
undetectable		 2aouA-3nyiA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzu ENDOGLUCANASE

(Bacillus
subtilis) 		PF00150
(Cellulase) 		4 ASP A 129
ASP A 195
TYR A 164
THR A 159
 None
 1.05A 2aouA-3pzuA:
undetectable		 2aouA-3pzuA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ASP A 636
GLY A 663
ASP A 570
TYR A 641
 None
 1.01A 2aouA-3sdqA:
undetectable		 2aouA-3sdqA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Rhodobacteraceae
bacterium KLH11) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 147
LYS A 151
GLY A 154
ASP A 392
 None
 0.95A 2aouA-3sszA:
undetectable		 2aouA-3sszA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 124
LYS A 128
GLY A 131
ASP A 369
 None
 0.99A 2aouA-3stpA:
undetectable		 2aouA-3stpA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty1 HYPOTHETICAL ALDOSE
1-EPIMERASE

(Klebsiella
pneumoniae) 		PF14486
(DUF4432) 		4 ASP A 255
LYS A 258
GLY A 260
THR A 322
 CL  A 504 ( 4.3A)
None
None
None
 1.00A 2aouA-3ty1A:
undetectable		 2aouA-3ty1A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zog FMN-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF01613
(Flavin_Reduct) 		4 ASP A  69
LYS A 151
PHE A 141
ASP A 138
 None
 1.05A 2aouA-3zogA:
undetectable		 2aouA-3zogA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 ASP A 242
LYS A 215
GLY A 218
THR A 171
 None
 0.98A 2aouA-3zu0A:
undetectable		 2aouA-3zu0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		4 GLY A1408
PHE A1409
ASP A1211
TYR A1204
 None
 0.91A 2aouA-4aygA:
undetectable		 2aouA-4aygA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA

(Brucella
abortus) 		PF00677
(Lum_binding) 		4 LYS A   1
GLY A   4
ASP A 146
THR A 172
 None
 1.02A 2aouA-4e0fA:
undetectable		 2aouA-4e0fA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl4 GLYCOSIDE HYDROLASE
FAMILY 9
CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION

(Ruminiclostridium
thermocellum;
Ruminiclostridium
thermocellum) 		PF00404
(Dockerin_1)
PF00963
(Cohesin) 		4 ASP A  35
GLY C  41
PHE C  87
ASP C  73
 CA  A 101 (-2.4A)
None
None
None
 0.89A 2aouA-4fl4A:
undetectable		 2aouA-4fl4A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqu PUTATIVE GLUTATHIONE
TRANSFERASE

(Sphingobium
chlorophenolicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 ASP A  35
GLY A  40
PHE A 149
ASP A 150
 None
 0.90A 2aouA-4fquA:
undetectable		 2aouA-4fquA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		4 ASP A 174
GLY A 336
PHE A 346
TYR A 129
 EDO  A 816 ( 3.2A)
None
GOL  A 806 ( 4.2A)
None
 0.80A 2aouA-4fusA:
undetectable		 2aouA-4fusA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g5e 2,4,6-TRICHLOROPHENO
L 4-MONOOXYGENASE

(Cupriavidus
pinatubonensis) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ASP A 214
GLY A 187
PHE A 259
THR A 221
 None
 1.03A 2aouA-4g5eA:
undetectable		 2aouA-4g5eA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js5 EXODEOXYRIBONUCLEASE
I

(Escherichia
coli) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		4 ASP A  55
PHE A  19
ASP A  26
TYR A  57
 None
 0.94A 2aouA-4js5A:
undetectable		 2aouA-4js5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3b OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Neisseria
gonorrhoeae) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		4 GLY A  69
PHE A  71
ASP A  73
TYR A  66
 None
 0.88A 2aouA-4k3bA:
undetectable		 2aouA-4k3bA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASP E  14
GLY E 151
ASP E 145
TYR E  12
 None
 0.92A 2aouA-4md8E:
undetectable		 2aouA-4md8E:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		4 GLY A 510
PHE A 513
ASP A 233
THR A 498
 None
 0.67A 2aouA-4mzdA:
2.0		 2aouA-4mzdA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Roseobacter
denitrificans) 		PF03480
(DctP) 		4 LYS A  53
GLY A  55
ASP A  25
TYR A  58
 None
 1.00A 2aouA-4ovqA:
undetectable		 2aouA-4ovqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmn TAT-SECRETED PROTEIN
RV2525C

(Mycobacterium
tuberculosis) 		PF08924
(DUF1906) 		4 ASP A  68
GLY A  78
ASP A  43
TYR A  65
 None
None
MES  A 301 ( 4.2A)
None
 0.84A 2aouA-4pmnA:
undetectable		 2aouA-4pmnA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmr TAT-SECRETED PROTEIN
RV2525C

(Mycobacterium
tuberculosis) 		PF08924
(DUF1906) 		4 ASP A  68
GLY A  78
ASP A  43
TYR A  65
 None
 0.88A 2aouA-4pmrA:
undetectable		 2aouA-4pmrA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C

(Zea mays) 		PF00171
(Aldedh) 		4 ASP A  62
LYS A  58
GLY A  56
ASP A  32
 None
 1.02A 2aouA-4pxlA:
3.1		 2aouA-4pxlA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		4 GLY A 122
PHE A 170
ASP A 201
TYR A 127
 None
 0.89A 2aouA-4raeA:
4.9		 2aouA-4raeA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 ASP P 472
TRP P 475
LYS P 476
GLY P 478
 None
 0.83A 2aouA-4s2tP:
undetectable		 2aouA-4s2tP:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tuf MAJOR EXTRACELLULAR
ENDOGLUCANASE

(Xanthomonas
campestris) 		PF00150
(Cellulase) 		4 ASP A 320
LYS A 316
PHE A 273
ASP A 275
 None
 0.97A 2aouA-4tufA:
1.4		 2aouA-4tufA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN

(Zobellia
galactanivorans) 		PF04616
(Glyco_hydro_43) 		4 ASP A 249
LYS A 264
GLY A 282
TYR A 262
 PEG  A 503 (-3.9A)
PEG  A 503 (-3.1A)
None
None
 0.93A 2aouA-4u6bA:
undetectable		 2aouA-4u6bA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE

(Colias
eurytheme) 		PF00342
(PGI) 		4 ASP A 238
GLY A 260
PHE A 259
THR A 226
 None
 1.00A 2aouA-4wmjA:
1.6		 2aouA-4wmjA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs SIMILARITY TO
HELICASE MOT1

(Encephalitozoon
cuniculi) 		no annotation 4 ASP C 224
GLY C 261
PHE C 249
ASP C 254
 None
 0.98A 2aouA-4wzsC:
undetectable		 2aouA-4wzsC:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4za3 RRNA N-GLYCOSIDASE

(Momordica
charantia) 		PF00652
(Ricin_B_lectin) 		4 GLY B 226
PHE B 122
ASP B 178
THR B  94
 None
 0.96A 2aouA-4za3B:
undetectable		 2aouA-4za3B:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 ASP A 954
PHE A 669
ASP A 560
THR A 665
 None
GLY  A1402 (-4.8A)
None
None
 1.05A 2aouA-4zxiA:
undetectable		 2aouA-4zxiA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF02775
(TPP_enzyme_C)
PF12367
(PFO_beta_C) 		4 LYS B 125
GLY B 122
TYR B 121
THR B 131
 None
TDN  B 402 (-3.5A)
TDN  B 402 (-4.4A)
None
 1.02A 2aouA-5b48B:
2.6		 2aouA-5b48B:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz0 REPLICASE
POLYPROTEIN 1AB

(Avian
coronavirus) 		PF08715
(Viral_protease) 		4 GLY A 252
ASP A 247
TYR A 294
THR A 202
 None
 0.87A 2aouA-5bz0A:
undetectable		 2aouA-5bz0A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cz3 M64R

(Myxoma virus) 		PF03287
(Pox_C7_F8A) 		4 ASP A  29
GLY A  32
ASP A  10
THR A 135
 None
 0.90A 2aouA-5cz3A:
undetectable		 2aouA-5cz3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LYS L 126
GLY L 128
ASP L 185
THR L 180
 None
 0.99A 2aouA-5dd5L:
undetectable		 2aouA-5dd5L:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 LYS A 240
GLY A 244
PHE A 296
ASP A 123
 None
 0.95A 2aouA-5df0A:
undetectable		 2aouA-5df0A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 LYS A 240
GLY A 244
PHE A 296
ASP A 125
 None
 0.93A 2aouA-5df0A:
undetectable		 2aouA-5df0A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzz DESMOPLAKIN

(Homo sapiens) 		PF00681
(Plectin) 		4 ASP A2136
GLY A2095
PHE A2096
ASP A2098
 None
 1.03A 2aouA-5dzzA:
undetectable		 2aouA-5dzzA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		4 ASP B 241
LYS B 245
GLY B 247
ASP B 250
 None
 1.05A 2aouA-5ergB:
12.1		 2aouA-5ergB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF01855
(POR_N)
PF17147
(PFOR_II) 		4 ASP A 168
GLY A 360
PHE A 117
ASP A 116
 None
None
None
5SR  C 402 (-3.3A)
 0.92A 2aouA-5exeA:
2.2		 2aouA-5exeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5feu NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE

(Narcissus
pseudonarcissus) 		PF13561
(adh_short_C2) 		4 ASP A 126
LYS A 117
GLY A 171
TYR A 175
 None
None
None
NAP  A 301 (-4.6A)
 1.05A 2aouA-5feuA:
7.1		 2aouA-5feuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE

(Narcissus
pseudonarcissus) 		PF13561
(adh_short_C2) 		4 ASP A 126
LYS A 117
GLY A 171
TYR A 175
 None
None
None
NAP  A 301 (-4.5A)
 1.03A 2aouA-5ff9A:
7.2		 2aouA-5ff9A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 LYS A 243
GLY A 247
PHE A 299
ASP A 127
 LYS  A 243 ( 0.0A)
GLY  A 247 ( 0.0A)
PHE  A 299 ( 1.3A)
ASP  A 127 ( 0.5A)
 1.03A 2aouA-5gprA:
undetectable		 2aouA-5gprA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho9 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 ASP A 473
GLY A 330
TYR A 470
THR A 322
 None
 1.01A 2aouA-5ho9A:
undetectable		 2aouA-5ho9A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		4 ASP A 557
PHE A 608
ASP A 606
THR A 309
 None
 1.04A 2aouA-5k3jA:
undetectable		 2aouA-5k3jA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2d SURFACE-ASSOCIATED
PROTEIN CSHA

(Streptococcus
gordonii) 		no annotation 4 ASP A  14
GLY A  88
PHE A   4
ASP A   6
 None
 0.99A 2aouA-5l2dA:
undetectable		 2aouA-5l2dA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mek CYTOSOLIC
SULFOTRANSFERASE 18

(Arabidopsis
thaliana) 		PF00685
(Sulfotransfer_1) 		4 ASP A 163
LYS A 167
GLY A 169
THR A 150
 None
None
None
EDO  A 414 ( 4.9A)
 0.98A 2aouA-5mekA:
undetectable		 2aouA-5mekA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE TLDD

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		4 ASP A 298
GLY A 268
PHE A 281
TYR A 332
 None
 0.95A 2aouA-5njfA:
undetectable		 2aouA-5njfA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oom 39S RIBOSOMAL
PROTEIN L23,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L47,
MITOCHONDRIAL

(Homo sapiens;
Homo sapiens) 		PF00276
(Ribosomal_L23)
PF06984
(MRP-L47) 		4 ASP Y  70
TRP Y  74
GLY Y  75
PHE U 111
 None
 0.88A 2aouA-5oomY:
undetectable		 2aouA-5oomY:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tp4 AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Burkholderia
ambifaria) 		PF01546
(Peptidase_M20) 		4 ASP A 184
LYS A 119
GLY A  71
THR A  56
 None
None
None
EDO  A 507 (-4.2A)
 0.93A 2aouA-5tp4A:
undetectable		 2aouA-5tp4A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		PF04095
(NAPRTase) 		4 ASP A 474
GLY A 122
PHE A 123
TYR A 471
 None
 0.85A 2aouA-5u2nA:
2.6		 2aouA-5u2nA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 4 ASP A 302
GLY A 142
PHE A 141
THR A 269
 None
None
FUM  A 702 (-4.3A)
FUM  A 702 (-3.4A)
 0.90A 2aouA-5xmjA:
undetectable		 2aouA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 ASP A  18
GLY A 155
ASP A 149
TYR A  16
 None
 0.90A 2aouA-5xvuA:
undetectable		 2aouA-5xvuA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		no annotation 4 GLY A 145
PHE A 148
ASP A 151
THR A 260
 None
 0.94A 2aouA-6bacA:
undetectable		 2aouA-6bacA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccu GLUCOSE-INDUCED
DEGRADATION PROTEIN
4 HOMOLOG

(Homo sapiens) 		no annotation 4 ASP A 196
LYS A 200
GLY A 203
PHE A 208
 None
 1.04A 2aouA-6ccuA:
undetectable		 2aouA-6ccuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckg D-GLYCERATE 3-KINASE

(Cryptococcus
neoformans) 		no annotation 4 ASP A  77
GLY A 145
ASP A  69
TYR A  72
 None
 0.95A 2aouA-6ckgA:
2.7		 2aouA-6ckgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1


(;
) 		no annotation
no annotation 		4 ASP D 110
GLY E 127
ASP E  43
THR D 216
 None
 1.04A 2aouA-6dw1D:
undetectable		 2aouA-6dw1D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emz INT PROTEIN

(Enterococcus
faecalis) 		no annotation 4 ASP A 234
GLY A 231
ASP A 298
TYR A 300
 None
 0.94A 2aouA-6emzA:
undetectable		 2aouA-6emzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 5 ASP g 181
LYS g 162
GLY g 164
PHE g 168
TYR g 179
 None
 1.39A 2aouA-6fkhg:
undetectable		 2aouA-6fkhg:
undetectable