SIMILAR PATTERNS OF AMINO ACIDS FOR 2AOT_B_2PMB401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jqe HISTAMINE
N-METHYLTRANSFERASE


(Homo sapiens)
PF13489
(Methyltransf_23)
9 PHE A  22
GLN A 143
TYR A 146
TYR A 147
TRP A 179
TRP A 183
CYH A 196
TYR A 198
PHE A 243
None
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
None
QUN  A 500 (-4.1A)
0.60A 2aotB-1jqeA:
42.5
2aotB-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jqe HISTAMINE
N-METHYLTRANSFERASE


(Homo sapiens)
PF13489
(Methyltransf_23)
8 PHE A  22
TYR A 146
TYR A 147
TRP A 183
CYH A 196
TYR A 198
PHE A 243
GLU A 246
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
None
QUN  A 500 (-4.1A)
QUN  A 500 (-3.9A)
0.84A 2aotB-1jqeA:
42.5
2aotB-1jqeA:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
5 PHE A1020
TYR A1018
PHE A1038
TYR A 989
GLU A1015
None
1.40A 2aotB-4g34A:
0.0
2aotB-4g34A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqs BETA-AMYLASE

(Ipomoea batatas)
no annotation 5 PHE A 264
TYR A 210
CYH A 209
TYR A 190
PHE A 250
None
1.46A 2aotB-5wqsA:
0.0
2aotB-5wqsA:
19.53