SIMILAR PATTERNS OF AMINO ACIDS FOR 2AOT_A_2PMA400_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1jqe	HISTAMINE N-METHYLTRANSFERASE (Homo sapiens)	PF13489 (Methyltransf_23)	8	GLN A 143 TYR A 146 TYR A 147 VAL A 173 TRP A 179 TRP A 183 TYR A 198 PHE A 243	None QUN A 500 (-3.3A) QUN A 500 ( 3.6A) None QUN A 500 (-3.6A) QUN A 500 (-4.9A) None QUN A 500 (-4.1A)	0.48A	2aotA-1jqeA: 42.6	2aotA-1jqeA: 99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1jqe	HISTAMINE N-METHYLTRANSFERASE (Homo sapiens)	PF13489 (Methyltransf_23)	5	TYR A 146 TYR A 147 VAL A 173 TRP A 179 PHE A 22	QUN A 500 (-3.3A) QUN A 500 ( 3.6A) None QUN A 500 (-3.6A) None	1.29A	2aotA-1jqeA: 42.6	2aotA-1jqeA: 99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3b74	UNCHARACTERIZED PROTEIN YKL091C (Saccharomyces cerevisiae)	PF00650 (CRAL_TRIO) PF03765 (CRAL_TRIO_N)	5	PHE A 57 TYR A 207 VAL A 150 TRP A 78 TYR A 206	None	1.38A	2aotA-3b74A: 0.1	2aotA-3b74A: 23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5iai	SUGAR ABC TRANSPORTER (Agrobacterium tumefaciens)	PF01547 (SBP_bac_1)	5	PHE A 49 GLN A 208 TYR A 154 VAL A 101 TRP A 102	None RB0 A 501 (-3.1A) None None None	1.40A	2aotA-5iaiA: 1.6	2aotA-5iaiA: 19.29

[["2AOT_A_2PMA400_1","1jqe","Homo sapiens","HISTAMINE N-METHYLTRANSFERASE","PF13489(Methyltransf_23)",8,"GLN A 143;TYR A 146;TYR A 147;VAL A 173;TRP A 179;TRP A 183;TYR A 198;PHE A 243","None;QUN A 500 (-3.3A);QUN A 500 ( 3.6A);None;QUN A 500 (-3.6A);QUN A 500 (-4.9A);None;QUN A 500 (-4.1A)","0.48A","2aotA-1jqeA:42.6","2aotA-1jqeA:99.66"],["2AOT_A_2PMA400_1","1jqe","Homo sapiens","HISTAMINE N-METHYLTRANSFERASE","PF13489(Methyltransf_23)",5,"TYR A 146;TYR A 147;VAL A 173;TRP A 179;PHE A  22","QUN A 500 (-3.3A);QUN A 500 ( 3.6A);None;QUN A 500 (-3.6A);None","1.29A","2aotA-1jqeA:42.6","2aotA-1jqeA:99.66"],["2AOT_A_2PMA400_1","3b74","Saccharomyces cerevisiae","UNCHARACTERIZED PROTEIN YKL091C","PF00650(CRAL_TRIO);PF03765(CRAL_TRIO_N)",5,"PHE A  57;TYR A 207;VAL A 150;TRP A  78;TYR A 206","None","1.38A","2aotA-3b74A:0.1","2aotA-3b74A:23.85"],["2AOT_A_2PMA400_1","5iai","Agrobacterium tumefaciens","SUGAR ABC TRANSPORTER","PF01547(SBP_bac_1)",5,"PHE A  49;GLN A 208;TYR A 154;VAL A 101;TRP A 102","None;RB0 A 501 (-3.1A);None;None;None","1.40A","2aotA-5iaiA:1.6","2aotA-5iaiA:19.29"]]