SIMILAR PATTERNS OF AMINO ACIDS FOR 2AOJ_C_FRDC305_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)

(Escherichia
coli) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain) 		4 LEU B1555
GLY B1521
ILE B1607
ILE B1582
 None
 0.67A 2aojB-1a9xB:
0.0		 2aojB-1a9xB:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agx GLUTAMINASE-ASPARAGI
NASE

(Acinetobacter
glutaminasificans) 		PF00710
(Asparaginase) 		4 LEU A  70
GLY A  51
ILE A   6
VAL A  74
 None
 0.76A 2aojB-1agxA:
0.0		 2aojB-1agxA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 LEU A 201
GLY A 253
ILE A 255
VAL A 246
ILE A 247
 None
 1.46A 2aojB-1ayeA:
undetectable		 2aojB-1ayeA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4j ANTIBODY

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.79A 2aojB-1b4jL:
0.0		 2aojB-1b4jL:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbj IGG4-KAPPA B72.3 FAB
(LIGHT CHAIN)

(Homo sapiens;
Mus musculus) 		no annotation 4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.78A 2aojB-1bbjL:
0.0		 2aojB-1bbjL:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgp BARLEY GRAIN
PEROXIDASE

(Hordeum vulgare) 		PF00141
(peroxidase) 		5 LEU A   9
GLY A 278
ILE A 281
PRO A   4
VAL A   5
 None
 1.41A 2aojB-1bgpA:
undetectable		 2aojB-1bgpA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		4 ASP A 296
GLY A 302
ILE A 303
VAL A 490
 None
 0.79A 2aojB-1cu1A:
1.4		 2aojB-1cu1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0q DNA PRIMASE

(Geobacillus
stearothermophilus) 		PF01807
(zf-CHC2) 		5 LEU A  29
GLY A  67
PRO A  41
VAL A  27
ILE A  23
 None
 1.29A 2aojB-1d0qA:
0.0		 2aojB-1d0qA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6v CHIMERIC GERMLINE
PRECURSOR OF
OXY-COPE CATALYTIC
ANTIBODY AZ-28
(LIGHT CHAIN)

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.80A 2aojB-1d6vL:
0.0		 2aojB-1d6vL:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9a HU ANTIGEN C

(Mus musculus) 		PF00076
(RRM_1) 		5 LEU A  63
GLY A  44
ILE A  33
VAL A  77
ILE A  75
 None
 1.39A 2aojB-1d9aA:
0.0		 2aojB-1d9aA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU A  90
GLY A 211
ILE A 213
VAL A 105
 None
 0.79A 2aojB-1ezvA:
undetectable		 2aojB-1ezvA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0k UDP-N-ACETYLGLUCOSAM
INE-N-ACETYLMURAMYL-
(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Escherichia
coli) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 LEU A 138
GLY A 119
ILE A 120
ILE A 141
 None
 0.77A 2aojB-1f0kA:
undetectable		 2aojB-1f0kA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb) 		4 LEU A 267
GLY A 161
ILE A 142
PRO A 138
 None
FAD  A 600 ( 4.0A)
FAD  A 600 (-3.7A)
None
 0.78A 2aojB-1f0xA:
undetectable		 2aojB-1f0xA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxl PARANEOPLASTIC
ENCEPHALOMYELITIS
ANTIGEN HUD

(Homo sapiens) 		PF00076
(RRM_1) 		5 LEU A 186
GLY A 167
ILE A 156
VAL A 200
ILE A 198
 None
 1.12A 2aojB-1fxlA:
undetectable		 2aojB-1fxlA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ

(Escherichia
virus G4) 		PF02306
(Phage_G) 		5 LEU 2  79
GLY 2  55
PRO 2  83
VAL 2  82
ILE 2 157
 None
 1.43A 2aojB-1gff2:
undetectable		 2aojB-1gff2:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 302
GLY A  31
ILE A  29
VAL A 257
ILE A 301
 None
FAD  A 600 (-3.2A)
None
None
None
 1.22A 2aojB-1gpeA:
undetectable		 2aojB-1gpeA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqp DOC1/APC10

(Saccharomyces
cerevisiae) 		PF03256
(ANAPC10) 		4 LEU A  67
GLY A 249
ILE A 250
PRO A 183
 None
 0.72A 2aojB-1gqpA:
undetectable		 2aojB-1gqpA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 281
GLY A 236
ILE A 258
PRO A 177
ILE A 245
 None
 1.36A 2aojB-1h74A:
undetectable		 2aojB-1h74A:
14.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		7 LEU A  23
ASP A  25
GLY A  49
ILE A  50
PRO A  81
VAL A  82
ILE A  84
 A79  A 800 ( 3.8A)
A79  A 800 (-2.7A)
A79  A 800 ( 3.7A)
A79  A 800 (-3.8A)
A79  A 800 ( 3.9A)
A79  A 800 (-4.5A)
A79  A 800 (-3.6A)
 0.60A 2aojB-1hvcA:
14.0		 2aojB-1hvcA:
46.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		7 LEU A  23
ASP A  25
GLY A  49
ILE A  50
PRO A  81
VAL A  82
ILE A  84
 A79  A 800 ( 4.0A)
A79  A 800 (-2.8A)
A79  A 800 (-3.4A)
A79  A 800 ( 4.0A)
A79  A 800 ( 3.4A)
A79  A 800 (-4.5A)
A79  A 800 (-3.8A)
 0.45A 2aojB-1hvcA:
14.0		 2aojB-1hvcA:
46.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 LEU A  23
GLY A  48
PRO A  81
VAL A  82
ILE A  84
 A79  A 800 ( 4.0A)
A79  A 800 (-4.1A)
A79  A 800 ( 3.4A)
A79  A 800 (-4.5A)
A79  A 800 (-3.8A)
 0.90A 2aojB-1hvcA:
14.0		 2aojB-1hvcA:
46.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipk BETA-CONGLYCININ,
BETA CHAIN

(Glycine max) 		PF00190
(Cupin_1)
PF07883
(Cupin_2) 		5 LEU A  33
GLY A 339
ILE A 271
VAL A 316
ILE A  51
 None
 1.34A 2aojB-1ipkA:
undetectable		 2aojB-1ipkA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1

(Streptomyces
coelicolor) 		PF01183
(Glyco_hydro_25) 		4 LEU A  97
GLY A 153
VAL A 135
ILE A 137
 None
 0.60A 2aojB-1jfxA:
undetectable		 2aojB-1jfxA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE

(Rattus
norvegicus) 		PF00459
(Inositol_P) 		4 LEU A 306
ILE A 207
PRO A 299
ILE A 265
 None
 0.79A 2aojB-1jp4A:
undetectable		 2aojB-1jp4A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum) 		PF03063
(Prismane) 		4 GLY A 513
ILE A 512
PRO A 243
ILE A 409
 None
 0.79A 2aojB-1jqkA:
undetectable		 2aojB-1jqkA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		5 LEU A 475
GLY A 223
ILE A 139
VAL A 474
ILE A 471
 None
 1.19A 2aojB-1k4yA:
undetectable		 2aojB-1k4yA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcv PC282 IMMUNOGLOBULIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.78A 2aojB-1kcvL:
undetectable		 2aojB-1kcvL:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE

(Pyrococcus
horikoshii) 		PF06026
(Rib_5-P_isom_A) 		4 LEU A 197
ILE A 149
VAL A 203
ILE A 200
 None
 0.79A 2aojB-1lk5A:
undetectable		 2aojB-1lk5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw7 TRANSCRIPTIONAL
REGULATOR NADR

(Haemophilus
influenzae) 		PF01467
(CTP_transf_like)
PF13521
(AAA_28) 		5 LEU A  88
GLY A  73
ILE A  75
VAL A  90
ILE A  63
 None
NAD  A 601 ( 4.2A)
None
None
None
 1.35A 2aojB-1lw7A:
undetectable		 2aojB-1lw7A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		5 LEU A  65
GLY A  18
PRO A 402
VAL A  23
ILE A  70
 None
 1.15A 2aojB-1lxyA:
undetectable		 2aojB-1lxyA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nba N-CARBAMOYLSARCOSINE
AMIDOHYDROLASE

(Arthrobacter
sp.) 		PF00857
(Isochorismatase) 		5 LEU A  52
ASP A 130
PRO A  73
VAL A  75
ILE A 133
 None
 1.39A 2aojB-1nbaA:
undetectable		 2aojB-1nbaA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npc NEUTRAL PROTEASE

(Bacillus cereus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 LEU A 165
GLY A 265
ILE A 267
ILE A 169
 None
 0.75A 2aojB-1npcA:
undetectable		 2aojB-1npcA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu5 CHLOROMUCONATE
CYCLOISOMERASE

(Pseudomonas sp.
P51) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 315
GLY A 290
ILE A 291
PRO A 319
 None
 0.73A 2aojB-1nu5A:
undetectable		 2aojB-1nu5A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		4 LEU A  80
GLY A  67
VAL A 449
ILE A  77
 None
FAD  A 652 (-3.4A)
None
None
 0.69A 2aojB-1o5wA:
undetectable		 2aojB-1o5wA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 TRIMETHYLAMINE
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 LEU A 650
GLY A 668
ILE A 666
VAL A 395
ILE A 485
 ADP  A1731 ( 4.6A)
None
None
ADP  A1731 (-4.7A)
None
 0.95A 2aojB-1o94A:
undetectable		 2aojB-1o94A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obf GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Achromobacter
xylosoxidans) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 LEU O 159
GLY O 136
ILE O 274
PRO O 165
VAL O 163
 None
 1.48A 2aojB-1obfO:
undetectable		 2aojB-1obfO:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 LEU B 186
GLY B 161
VAL B 200
ILE B 189
 None
 0.76A 2aojB-1pjmB:
undetectable		 2aojB-1pjmB:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 296
GLY A  72
ILE A  71
VAL A  39
 None
 0.65A 2aojB-1pxtA:
undetectable		 2aojB-1pxtA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51

(Pyrococcus
furiosus) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 LEU A 234
GLY A 346
ILE A 347
VAL A 155
 None
 0.80A 2aojB-1pznA:
undetectable		 2aojB-1pznA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		4 LEU A 404
ASP A 408
GLY A 376
VAL A 390
 None
 0.77A 2aojB-1q50A:
undetectable		 2aojB-1q50A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		5 LEU A 588
GLY A 481
ILE A 480
VAL A 681
ILE A 605
 None
 1.30A 2aojB-1qafA:
undetectable		 2aojB-1qafA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrp PEPSIN 3A

(Homo sapiens) 		PF00026
(Asp) 		5 LEU E 155
ASP E 303
GLY E  34
VAL E 153
ILE E 306
 None
None
HH0  E 327 (-4.1A)
None
None
 1.09A 2aojB-1qrpE:
6.8		 2aojB-1qrpE:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A 108
ILE A  71
PRO A  75
VAL A  78
ILE A 112
 None
 1.36A 2aojB-1rpnA:
undetectable		 2aojB-1rpnA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2j PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 LEU A  58
GLY A 108
ILE A 109
ILE A  74
 None
 0.78A 2aojB-1s2jA:
undetectable		 2aojB-1s2jA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1scj SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 LEU A 250
GLY A   7
ILE A   8
VAL A 227
ILE A 268
 None
 1.49A 2aojB-1scjA:
undetectable		 2aojB-1scjA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		4 LEU A 116
GLY A 136
ILE A 135
ILE A 117
 None
None
SAM  A 301 (-4.8A)
None
 0.79A 2aojB-1sg9A:
undetectable		 2aojB-1sg9A:
16.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		6 LEU A  23
ASP A  25
GLY A  49
ILE A  50
PRO A  81
ILE A  84
 None
 0.54A 2aojB-1sivA:
18.6		 2aojB-1sivA:
51.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 LEU A  58
GLY A 108
ILE A 109
ILE A  74
 None
 0.78A 2aojB-1sxrA:
undetectable		 2aojB-1sxrA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 LEU A 528
GLY A 692
ILE A 691
VAL A 669
ILE A 698
 None
 1.33A 2aojB-1t6pA:
undetectable		 2aojB-1t6pA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS

(Escherichia
coli) 		PF01614
(IclR) 		5 LEU A 180
GLY A  46
ILE A  45
VAL A  16
ILE A 176
 None
 1.11A 2aojB-1tf1A:
undetectable		 2aojB-1tf1A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 233
GLY A 152
VAL A 243
ILE A 237
 None
 0.74A 2aojB-1tt7A:
undetectable		 2aojB-1tt7A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3b AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING,
FAMILY A, MEMBER 1

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A 101
GLY A  67
ILE A  66
VAL A  21
ILE A 103
 None
 1.15A 2aojB-1u3bA:
undetectable		 2aojB-1u3bA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A  67
GLY A  17
PRO A  31
VAL A   8
 None
 0.77A 2aojB-1uagA:
undetectable		 2aojB-1uagA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		4 LEU A 515
GLY A 399
VAL A 509
ILE A 507
 None
 0.73A 2aojB-1uc4A:
undetectable		 2aojB-1uc4A:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 OUTER CAPSID PROTEIN
P8

(Rice dwarf
virus) 		no annotation 5 LEU P 273
GLY P 195
PRO P 212
VAL P 211
ILE P 278
 None
 1.42A 2aojB-1uf2P:
undetectable		 2aojB-1uf2P:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 441
GLY A 500
ILE A 499
ILE A 445
 None
 0.76A 2aojB-1uhlA:
undetectable		 2aojB-1uhlA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX

(Helicobacter
pylori) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 LEU A 337
GLY A 283
ILE A 287
ILE A 148
 None
 0.79A 2aojB-1um8A:
undetectable		 2aojB-1um8A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdm PURINE
PHOSPHORIBOSYLTRANSF
ERASE

(Pyrococcus
horikoshii) 		PF00156
(Pribosyltran) 		5 GLY A  49
ILE A  47
PRO A  27
VAL A  87
ILE A  30
 None
 1.49A 2aojB-1vdmA:
undetectable		 2aojB-1vdmA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 LEU A  68
GLY A 151
ILE A  14
VAL A  80
ILE A 140
 None
 1.15A 2aojB-1ve5A:
undetectable		 2aojB-1ve5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ASP A  46
GLY A 135
ILE A  62
PRO A  58
VAL A  57
 None
 1.37A 2aojB-1vj0A:
undetectable		 2aojB-1vj0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 135
ILE A  62
PRO A  58
VAL A  57
ILE A 123
 None
None
None
None
UNL  A2001 ( 4.8A)
 1.45A 2aojB-1vj0A:
undetectable		 2aojB-1vj0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vr0 PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE

(Clostridium
acetobutylicum) 		PF04029
(2-ph_phosp) 		5 LEU A  38
ILE A 118
PRO A  47
VAL A  45
ILE A  34
 None
 1.17A 2aojB-1vr0A:
undetectable		 2aojB-1vr0A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 LEU A 166
GLY A 178
ILE A 102
PRO A 169
VAL A 168
 None
FAD  A1561 ( 3.8A)
FAD  A1561 (-3.7A)
FAD  A1561 (-4.7A)
None
 1.22A 2aojB-1w1kA:
undetectable		 2aojB-1w1kA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5f CELL DIVISION
PROTEIN FTSZ

(Thermotoga
maritima) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 LEU A  93
GLY A 118
PRO A 125
VAL A 126
 None
G2P  A 500 (-3.4A)
None
None
 0.78A 2aojB-1w5fA:
undetectable		 2aojB-1w5fA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		4 LEU A 644
GLY A 593
ILE A 594
ILE A 585
 None
 0.79A 2aojB-1w7cA:
undetectable		 2aojB-1w7cA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8a SLIT PROTEIN

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 GLY A 609
ILE A 610
VAL A 658
ILE A 655
 None
 0.74A 2aojB-1w8aA:
undetectable		 2aojB-1w8aA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		4 LEU A 252
PRO A 261
VAL A 260
ILE A 258
 None
 0.77A 2aojB-1wacA:
undetectable		 2aojB-1wacA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu7 HISTIDYL-TRNA
SYNTHETASE

(Thermoplasma
acidophilum) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 LEU A 202
GLY A 174
ILE A 171
VAL A 212
ILE A 207
 None
 1.27A 2aojB-1wu7A:
undetectable		 2aojB-1wu7A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvg CDP-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		4 LEU A  51
GLY A 341
VAL A  55
ILE A  54
 None
 0.75A 2aojB-1wvgA:
undetectable		 2aojB-1wvgA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		no annotation 5 LEU A  96
GLY A  85
ILE A 128
PRO A  89
VAL A  92
 None
 1.44A 2aojB-1xksA:
undetectable		 2aojB-1xksA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN
ASPERGILLOPEPSIN II
LIGHT CHAIN

(Aspergillus
niger) 		PF01828
(Peptidase_A4) 		5 ASP B  14
GLY A  14
ILE A  13
VAL A  20
ILE B  13
 None
 1.50A 2aojB-1y43B:
undetectable		 2aojB-1y43B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii) 		PF01266
(DAO) 		5 LEU B  90
GLY B 265
ILE B 264
VAL B 242
ILE B 243
 None
 1.44A 2aojB-1y56B:
undetectable		 2aojB-1y56B:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 LEU A 224
GLY A 220
ILE A 217
VAL A 205
ILE A 203
 None
 1.35A 2aojB-1ydfA:
undetectable		 2aojB-1ydfA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytu HYPOTHETICAL PROTEIN
AF1318

(Archaeoglobus
fulgidus) 		PF02171
(Piwi) 		4 LEU A  64
GLY A 110
ILE A 111
ILE A  68
 None
 0.79A 2aojB-1ytuA:
undetectable		 2aojB-1ytuA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zan FAB AD11 LIGHT CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 180
GLY L 129
PRO L 121
VAL L 133
 None
 0.75A 2aojB-1zanL:
undetectable		 2aojB-1zanL:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a33 HYPOTHETICAL PROTEIN

(Arabidopsis
thaliana) 		PF03641
(Lysine_decarbox) 		4 GLY A 136
ILE A 137
VAL A 142
ILE A 174
 None
 0.60A 2aojB-2a33A:
undetectable		 2aojB-2a33A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmf RNA HELICASE

(Dengue virus) 		PF07652
(Flavi_DEAD) 		5 LEU A 204
GLY A 311
ILE A 281
VAL A 208
ILE A 207
 None
 1.10A 2aojB-2bmfA:
undetectable		 2aojB-2bmfA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwa ENDOGLUCANASE

(Rhodothermus
marinus) 		PF01670
(Glyco_hydro_12) 		4 LEU A   5
GLY A 205
VAL A  36
ILE A  34
 None
 0.74A 2aojB-2bwaA:
undetectable		 2aojB-2bwaA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bws XAA-PRO
AMINOPEPTIDASE P

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 LEU A 433
ILE A 259
VAL A 424
ILE A 430
 None
 0.69A 2aojB-2bwsA:
undetectable		 2aojB-2bwsA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Sulfolobus
solfataricus) 		PF00218
(IGPS) 		4 LEU A  38
GLY A 178
ILE A 177
ILE A  37
 None
 0.66A 2aojB-2c3zA:
undetectable		 2aojB-2c3zA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		5 LEU A  36
GLY A  47
ILE A   7
VAL A  32
ILE A  33
 None
 1.11A 2aojB-2cevA:
undetectable		 2aojB-2cevA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 LEU A 277
ILE A 200
VAL A 218
ILE A 288
 None
 0.77A 2aojB-2cvzA:
undetectable		 2aojB-2cvzA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Synechococcus
sp.) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LEU A  29
ILE A 150
VAL A   5
ILE A   3
 None
 0.79A 2aojB-2d2iA:
undetectable		 2aojB-2d2iA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 LEU A  36
GLY A  88
ILE A  87
VAL A  75
ILE A  18
 None
 1.20A 2aojB-2e8yA:
undetectable		 2aojB-2e8yA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5a PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.70A 2aojB-2f5aL:
undetectable		 2aojB-2f5aL:
16.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		6 LEU A  23
ASP A  25
GLY A  55
PRO A  86
VAL A  87
ILE A  89
 None
LP1  A 201 (-2.3A)
LP1  A 201 (-3.4A)
LP1  A 201 (-3.9A)
LP1  A 201 ( 4.9A)
LP1  A 201 (-4.2A)
 0.41A 2aojB-2fmbA:
15.1		 2aojB-2fmbA:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A  50
GLY A 113
VAL A  88
ILE A  90
 None
 0.72A 2aojB-2fqdA:
undetectable		 2aojB-2fqdA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0t CONSERVED
HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF07755
(DUF1611)
PF17396
(DUF1611_N) 		4 GLY A 202
ILE A 201
VAL A 208
ILE A 138
 None
 0.71A 2aojB-2g0tA:
undetectable		 2aojB-2g0tA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h39 PROBABLE
GALACTOSE-1-PHOSPHAT
E URIDYL TRANSFERASE

(Arabidopsis
thaliana) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		4 GLY A 144
PRO A 131
VAL A 132
ILE A 135
 None
 0.63A 2aojB-2h39A:
undetectable		 2aojB-2h39A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		5 LEU A 268
ASP A 211
GLY A   9
VAL A 285
ILE A 228
 None
ADP  A 472 ( 4.3A)
ADP  A 472 (-3.9A)
None
None
 1.41A 2aojB-2hmfA:
undetectable		 2aojB-2hmfA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE

(Pyrococcus
horikoshii) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A 231
GLY A  16
ILE A  20
VAL A 123
ILE A 227
 None
 1.43A 2aojB-2hunA:
undetectable		 2aojB-2hunA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0o SER/THR PHOSPHATASE

(Anopheles
gambiae) 		PF00481
(PP2C) 		4 ASP A 479
GLY A 470
PRO A 445
ILE A 495
 None
 0.79A 2aojB-2i0oA:
undetectable		 2aojB-2i0oA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jil GLUTAMATE RECEPTOR
INTERACTING
PROTEIN-1

(Homo sapiens) 		PF00595
(PDZ) 		4 LEU A 223
GLY A 213
VAL A 206
ILE A 222
 None
 0.76A 2aojB-2jilA:
undetectable		 2aojB-2jilA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum) 		PF00710
(Asparaginase) 		4 LEU A  73
GLY A  14
ILE A  16
VAL A  57
 None
ASP  A1328 (-3.2A)
None
None
 0.77A 2aojB-2jk0A:
undetectable		 2aojB-2jk0A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4m UPF0146 PROTEIN
MTH_1000

(Methanothermobacter
thermautotrophicus) 		PF03686
(UPF0146) 		4 LEU A  92
GLY A  43
ILE A  96
VAL A  39
 None
 0.71A 2aojB-2k4mA:
undetectable		 2aojB-2k4mA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lnv GENERAL SECRETION
PATHWAY PROTEIN C

(Dickeya
dadantii) 		PF11356
(T2SSC) 		4 LEU A 145
GLY A  99
PRO A 129
ILE A 135
 None
 0.79A 2aojB-2lnvA:
undetectable		 2aojB-2lnvA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nr4 CONSERVED
HYPOTHETICAL PROTEIN

(Methanosarcina
mazei) 		PF04289
(DUF447) 		5 LEU A 112
GLY A  47
ILE A  48
VAL A  80
ILE A  33
 None
FMN  A 401 (-3.6A)
None
None
None
 1.49A 2aojB-2nr4A:
1.2		 2aojB-2nr4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nr7 SECRETION ACTIVATOR
PROTEIN, PUTATIVE

(Porphyromonas
gingivalis) 		PF05838
(Glyco_hydro_108)
PF09374
(PG_binding_3) 		5 LEU A 134
GLY A 102
ILE A 103
VAL A  87
ILE A 138
 None
 0.85A 2aojB-2nr7A:
undetectable		 2aojB-2nr7A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 300
ILE A 102
VAL A 322
ILE A 320
 None
 0.78A 2aojB-2o56A:
undetectable		 2aojB-2o56A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obx 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1

(Mesorhizobium
loti) 		PF00885
(DMRL_synthase) 		4 LEU A  75
GLY A  41
ILE A  40
ILE A  14
 None
 0.75A 2aojB-2obxA:
undetectable		 2aojB-2obxA:
21.19