SIMILAR PATTERNS OF AMINO ACIDS FOR 2AOJ_C_FRDC305_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad9 IGG CTM01 FAB (LIGHT
CHAIN)

(Homo sapiens) 		no annotation 4 LEU L 178
GLY L 127
PRO L 119
VAL L 131
 None
 0.92A 2aojA-1ad9L:
undetectable		 2aojA-1ad9L:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4j ANTIBODY

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.84A 2aojA-1b4jL:
undetectable		 2aojA-1b4jL:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbj IGG4-KAPPA B72.3 FAB
(LIGHT CHAIN)

(Homo sapiens;
Mus musculus) 		no annotation 4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.83A 2aojA-1bbjL:
undetectable		 2aojA-1bbjL:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6v CHIMERIC GERMLINE
PRECURSOR OF
OXY-COPE CATALYTIC
ANTIBODY AZ-28
(LIGHT CHAIN)

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.85A 2aojA-1d6vL:
undetectable		 2aojA-1d6vL:
15.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 LEU A  23
ASP A  25
GLY A  49
PRO A  81
VAL A  82
 A79  A 800 ( 3.8A)
A79  A 800 (-2.7A)
A79  A 800 ( 3.7A)
A79  A 800 ( 3.9A)
A79  A 800 (-4.5A)
 0.57A 2aojA-1hvcA:
14.1		 2aojA-1hvcA:
46.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 LEU A  23
ASP A  25
GLY A  49
PRO A  81
VAL A  82
 A79  A 800 ( 4.0A)
A79  A 800 (-2.8A)
A79  A 800 (-3.4A)
A79  A 800 ( 3.4A)
A79  A 800 (-4.5A)
 0.40A 2aojA-1hvcA:
14.1		 2aojA-1hvcA:
46.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
GLY A  48
PRO A  81
VAL A  82
 A79  A 800 ( 3.8A)
A79  A 800 (-4.1A)
A79  A 800 ( 3.9A)
A79  A 800 (-4.5A)
 0.88A 2aojA-1hvcA:
14.1		 2aojA-1hvcA:
46.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcv PC282 IMMUNOGLOBULIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.84A 2aojA-1kcvL:
undetectable		 2aojA-1kcvL:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mim CHIMERIC SDZ CHI621

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 176
GLY L 125
PRO L 117
VAL L 129
 None
 0.92A 2aojA-1mimL:
undetectable		 2aojA-1mimL:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pie GALACTOKINASE

(Lactococcus
lactis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 LEU A 198
ASP A 199
GLY A 257
VAL A  51
 None
 0.90A 2aojA-1pieA:
undetectable		 2aojA-1pieA:
12.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
 None
 0.50A 2aojA-1sivA:
18.5		 2aojA-1sivA:
51.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A  67
GLY A  12
PRO A  31
VAL A   8
 None
UMA  A 963 ( 4.1A)
None
None
 0.83A 2aojA-1uagA:
undetectable		 2aojA-1uagA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A  67
GLY A  17
PRO A  31
VAL A   8
 None
 0.70A 2aojA-1uagA:
undetectable		 2aojA-1uagA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 LEU A 500
GLY A  25
PRO A 135
VAL A 134
 None
 0.91A 2aojA-1vkoA:
undetectable		 2aojA-1vkoA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5f CELL DIVISION
PROTEIN FTSZ

(Thermotoga
maritima) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 LEU A  93
GLY A 118
PRO A 125
VAL A 126
 None
G2P  A 500 (-3.4A)
None
None
 0.82A 2aojA-1w5fA:
undetectable		 2aojA-1w5fA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zan FAB AD11 LIGHT CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 180
GLY L 129
PRO L 121
VAL L 133
 None
 0.80A 2aojA-1zanL:
undetectable		 2aojA-1zanL:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2x ANTIBODY AQC2 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 183
GLY L 132
PRO L 124
VAL L 136
 None
 0.92A 2aojA-2b2xL:
undetectable		 2aojA-2b2xL:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq3 SERYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 LEU A 382
GLY A 190
PRO A 251
VAL A 290
 None
 0.91A 2aojA-2dq3A:
undetectable		 2aojA-2dq3A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5a PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.82A 2aojA-2f5aL:
undetectable		 2aojA-2f5aL:
16.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		5 LEU A  23
ASP A  25
GLY A  55
PRO A  86
VAL A  87
 None
LP1  A 201 (-2.3A)
LP1  A 201 (-3.4A)
LP1  A 201 (-3.9A)
LP1  A 201 ( 4.9A)
 0.50A 2aojA-2fmbA:
14.9		 2aojA-2fmbA:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE

(Azospirillum
brasilense) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 207
GLY A 239
PRO A 250
VAL A 233
 None
PPY  A5003 ( 4.1A)
None
None
 0.82A 2aojA-2q5oA:
undetectable		 2aojA-2q5oA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ

(Aquifex
aeolicus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 LEU 1  79
GLY 1 104
PRO 1 111
VAL 1 112
 None
GDP  1 339 (-3.4A)
None
None
 0.81A 2aojA-2r6r1:
undetectable		 2aojA-2r6r1:
16.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
 None
AB1  A 501 (-2.4A)
AB1  A 501 (-3.5A)
AB1  A 501 (-4.2A)
 0.50A 2aojA-2rkfA:
20.7		 2aojA-2rkfA:
82.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfk CATALYTIC ANTIBODY
FAB 34E4 LIGHT
CHAIN,UNCHARACTERIZE
D PROTEIN

(Homo sapiens;
Mus musculus) 		no annotation 4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.92A 2aojA-3cfkL:
undetectable		 2aojA-3cfkL:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvh 25-D1.16 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 178
GLY L 127
PRO L 119
VAL L 131
 None
 0.91A 2aojA-3cvhL:
undetectable		 2aojA-3cvhL:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxj PYRROLO-QUINOLINE
QUINONE

(Methanococcus
maripaludis) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13570
(PQQ_3) 		5 LEU A  35
ASP A 303
GLY A 263
PRO A 300
VAL A 301
 None
 1.40A 2aojA-3hxjA:
undetectable		 2aojA-3hxjA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ian CHITINASE

(Lactococcus
lactis) 		PF00704
(Glyco_hydro_18) 		4 LEU A 121
ASP A 158
GLY A 282
VAL A  79
 None
 0.84A 2aojA-3ianA:
undetectable		 2aojA-3ianA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikc IMMUNOGLOBULIN LIGHT
CHAIN (IGG3)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU A 178
GLY A 127
PRO A 119
VAL A 131
 None
 0.92A 2aojA-3ikcA:
undetectable		 2aojA-3ikcA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1l 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		4 LEU A  49
GLY A 101
PRO A 108
VAL A 109
 None
 0.79A 2aojA-3m1lA:
undetectable		 2aojA-3m1lA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU A 179
GLY A 128
PRO A 120
VAL A 132
 None
 0.81A 2aojA-3mnzA:
undetectable		 2aojA-3mnzA:
17.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 LEU A  23
ASP A  25
GLY A  49
PRO A  81
VAL A  82
 None
 0.49A 2aojA-3mwsA:
20.2		 2aojA-3mwsA:
79.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntc FAB LIGHT CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.88A 2aojA-3ntcL:
undetectable		 2aojA-3ntcL:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpx FAB C2507 LIGHT
CHAIN

(Homo sapiens;
Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 178
GLY L 127
PRO L 119
VAL L 131
 None
 0.90A 2aojA-3qpxL:
undetectable		 2aojA-3qpxL:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru8 ANTIBODY B12, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 180
GLY L 129
PRO L 121
VAL L 133
 None
 0.81A 2aojA-3ru8L:
undetectable		 2aojA-3ru8L:
15.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
 SO4  A 101 (-4.2A)
017  A 201 (-2.6A)
017  A 201 (-4.0A)
None
 0.59A 2aojA-3t3cA:
18.7		 2aojA-3t3cA:
74.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
 None
017  A 201 (-2.6A)
017  A 201 (-3.0A)
017  A 201 (-4.1A)
 0.37A 2aojA-3ttpA:
19.8		 2aojA-3ttpA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 LEU A 513
ASP A 542
GLY A 522
PRO A 567
 None
 0.87A 2aojA-3u1kA:
undetectable		 2aojA-3u1kA:
10.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u7s POL POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
 None
017  A 202 ( 2.5A)
017  A 202 (-2.9A)
017  A 202 (-4.0A)
 0.34A 2aojA-3u7sA:
20.0		 2aojA-3u7sA:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uhl PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
PRO A  81
VAL A  82
 None
 0.54A 2aojA-3uhlA:
16.1		 2aojA-3uhlA:
80.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4alq CHITIN BINDING
PROTEIN

(Enterococcus
faecalis) 		PF03067
(LPMO_10) 		4 ASP A 180
GLY A 177
PRO A 152
VAL A 151
 None
 0.82A 2aojA-4alqA:
undetectable		 2aojA-4alqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axn CHITINASE C1

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		4 LEU A 100
ASP A 137
GLY A 261
VAL A  61
 None
 0.89A 2aojA-4axnA:
undetectable		 2aojA-4axnA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bof ARGININE DEIMINASE

(Streptococcus
pyogenes) 		PF02274
(Amidinotransf) 		4 LEU A  61
GLY A  14
PRO A 405
VAL A  19
 None
 0.89A 2aojA-4bofA:
undetectable		 2aojA-4bofA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 LEU A  85
ASP A  99
PRO A 180
VAL A 179
 None
 0.87A 2aojA-4e4gA:
undetectable		 2aojA-4e4gA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE

(Lechevalieria
aerocolonigenes) 		PF01494
(FAD_binding_3) 		4 LEU A  25
ASP A  24
GLY A 454
VAL A  30
 None
 0.91A 2aojA-4eipA:
undetectable		 2aojA-4eipA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6a AP33 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU D 179
GLY D 128
PRO D 120
VAL D 132
 None
 0.79A 2aojA-4g6aD:
undetectable		 2aojA-4g6aD:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjj ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 293
GLY L 242
PRO L 234
VAL L 246
 None
 0.83A 2aojA-4hjjL:
undetectable		 2aojA-4hjjL:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht1 CHIMERIC ANTIBODY
FAB

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 183
GLY L 132
PRO L 124
VAL L 136
 None
 0.91A 2aojA-4ht1L:
undetectable		 2aojA-4ht1L:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		4 LEU B 547
ASP B 546
GLY B 289
VAL B 472
 None
 0.84A 2aojA-4i0wB:
undetectable		 2aojA-4i0wB:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3r LIGHT CHAIN OF
VRC-PG04 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.91A 2aojA-4i3rL:
undetectable		 2aojA-4i3rL:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)

(Homo sapiens) 		no annotation 4 LEU H 201
GLY H 150
PRO H 142
VAL H 154
 None
 0.82A 2aojA-4imlH:
undetectable		 2aojA-4imlH:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6r LIGHT CHAIN OF
ANTIBODY VRC23

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.80A 2aojA-4j6rL:
undetectable		 2aojA-4j6rL:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jfz FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.89A 2aojA-4jfzL:
undetectable		 2aojA-4jfzL:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jm4 PGT 135 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.89A 2aojA-4jm4L:
undetectable		 2aojA-4jm4L:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr9 IMMUNOGLOBULIN
KAPPA, LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 178
GLY L 127
PRO L 119
VAL L 131
 None
 0.91A 2aojA-4jr9L:
undetectable		 2aojA-4jr9L:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzn ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B 178
GLY B 127
PRO B 119
VAL B 131
 None
 0.91A 2aojA-4jznB:
undetectable		 2aojA-4jznB:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjz TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2) 		4 ASP A 416
GLY A 410
PRO A 435
VAL A 438
 None
 0.83A 2aojA-4kjzA:
undetectable		 2aojA-4kjzA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsq LIGHT CHAIN OF
ANTIBODY VRC-CH31
WITH N70D MUTATION

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.86A 2aojA-4lsqL:
undetectable		 2aojA-4lsqL:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ma3 C2095 LIGHT CHAIN

(Homo sapiens;
Oryctolagus
cuniculus) 		no annotation 4 LEU L 185
GLY L 134
PRO L 126
VAL L 138
 None
 0.86A 2aojA-4ma3L:
undetectable		 2aojA-4ma3L:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb5 CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18)
PF16403
(DUF5011) 		4 LEU A 112
ASP A 149
GLY A 272
VAL A  65
 None
 0.84A 2aojA-4mb5A:
undetectable		 2aojA-4mb5A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0n REPLICASE
POLYPROTEIN 1AB

(Equine
arteritis virus) 		PF01443
(Viral_helicase1) 		4 LEU A 181
GLY A 263
PRO A 184
VAL A 183
 None
 0.90A 2aojA-4n0nA:
undetectable		 2aojA-4n0nA:
13.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
 None
RIT  A 500 (-2.4A)
RIT  A 500 (-3.4A)
RIT  A 500 (-3.9A)
 0.45A 2aojA-4njvA:
21.0		 2aojA-4njvA:
84.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Mycobacterium
tuberculosis) 		PF01497
(Peripla_BP_2) 		4 LEU A 100
GLY A  38
PRO A  52
VAL A  34
 None
 0.88A 2aojA-4pm4A:
undetectable		 2aojA-4pm4A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmu ENDO-1,4-BETA-XYLANA
SE A

(Xanthomonas
citri) 		PF00331
(Glyco_hydro_10) 		4 LEU A 295
GLY A 274
PRO A 347
VAL A 348
 None
 0.92A 2aojA-4pmuA:
undetectable		 2aojA-4pmuA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r96 LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET L
CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU A 185
GLY A 134
PRO A 126
VAL A 138
 None
 0.88A 2aojA-4r96A:
undetectable		 2aojA-4r96A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rx4 8ANC134 LIGHT CHAIN

(Homo sapiens) 		no annotation 4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.90A 2aojA-4rx4L:
undetectable		 2aojA-4rx4L:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 4 ASP A 437
GLY A 494
PRO A 261
VAL A 262
 None
 0.86A 2aojA-4tz5A:
undetectable		 2aojA-4tz5A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18) 		4 LEU A 112
ASP A 149
GLY A 272
VAL A  65
 None
 0.83A 2aojA-4w5zA:
undetectable		 2aojA-4w5zA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmp LIGHT CHAIN OF
ANTIBODY VRC08

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.89A 2aojA-4xmpL:
undetectable		 2aojA-4xmpL:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xny LIGHT CHAIN OF
ANTIBODY VRC08C

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.92A 2aojA-4xnyL:
undetectable		 2aojA-4xnyL:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydi LIGHT CHAIN OF
ANTIBODY
Z258-VRC27.01

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.83A 2aojA-4ydiL:
undetectable		 2aojA-4ydiL:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydk LIGHT CHAIN OF
ANTIBODY
C38-VRC16.01

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.86A 2aojA-4ydkL:
undetectable		 2aojA-4ydkL:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydl LIGHT CHAIN OF
ANTIBODY
C38-VRC18.02

(Homo sapiens) 		no annotation 4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.83A 2aojA-4ydlL:
undetectable		 2aojA-4ydlL:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydv HIV ANTIBODY 7B2
LIGHT CHAIN,IG KAPPA
CHAIN C REGION

(Homo sapiens) 		no annotation 4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.88A 2aojA-4ydvL:
undetectable		 2aojA-4ydvL:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye4 LIGHT CHAIN OF HJ16

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 186
GLY L 135
PRO L 127
VAL L 139
 None
 0.85A 2aojA-4ye4L:
undetectable		 2aojA-4ye4L:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ado FAB A.17

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 181
GLY L 130
PRO L 122
VAL L 134
 None
 0.91A 2aojA-5adoL:
undetectable		 2aojA-5adoL:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum) 		no annotation 4 ASP B 442
GLY B 266
PRO B 260
VAL B 394
 None
 0.92A 2aojA-5cwwB:
undetectable		 2aojA-5cwwB:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.84A 2aojA-5dd5L:
undetectable		 2aojA-5dd5L:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5drz HIV ANTIBODY F240
LIGHT CHAIN

(Homo sapiens) 		no annotation 4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.83A 2aojA-5drzL:
undetectable		 2aojA-5drzL:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqn FRBJ

(Streptomyces
rubellomurinus) 		PF02668
(TauD) 		4 LEU A  85
GLY A  33
PRO A  89
VAL A  88
 None
 0.88A 2aojA-5eqnA:
undetectable		 2aojA-5eqnA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es6 LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00551
(Formyl_trans_N) 		4 LEU A 388
GLY A 226
PRO A 416
VAL A 415
 None
 0.89A 2aojA-5es6A:
undetectable		 2aojA-5es6A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgc ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B 179
GLY B 128
PRO B 120
VAL B 132
 None
 0.88A 2aojA-5fgcB:
undetectable		 2aojA-5fgcB:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htv PUTATIVE XYLULOSE
KINASE

(Arabidopsis
thaliana) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A  13
GLY A  39
PRO A  70
VAL A  73
 None
 0.90A 2aojA-5htvA:
undetectable		 2aojA-5htvA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8k HHH1 FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 182
GLY L 131
PRO L 123
VAL L 135
 None
 0.81A 2aojA-5i8kL:
undetectable		 2aojA-5i8kL:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8o HMM5 ANTIBODY LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 182
GLY L 131
PRO L 123
VAL L 135
 None
 0.81A 2aojA-5i8oL:
undetectable		 2aojA-5i8oL:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		no annotation 4 LEU C 388
GLY C 226
PRO C 416
VAL C 415
 None
 0.91A 2aojA-5jnfC:
undetectable		 2aojA-5jnfC:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kan 16.G.07 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU I 179
GLY I 128
PRO I 120
VAL I 132
 None
 0.91A 2aojA-5kanI:
undetectable		 2aojA-5kanI:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbi DESIGN OF ANTIBODIES

(Escherichia
coli) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 183
GLY L 132
PRO L 124
VAL L 136
 None
 0.84A 2aojA-5nbiL:
undetectable		 2aojA-5nbiL:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN

(Chaetomium
thermophilum) 		no annotation 4 LEU A1824
GLY A1842
PRO A1811
VAL A1810
 None
 0.90A 2aojA-5nnlA:
undetectable		 2aojA-5nnlA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ock HUMAN ACPA E4 FAB
FRAGMENT - LIGHT
CHAIN

(Homo sapiens) 		no annotation 4 LEU L 182
GLY L 131
PRO L 123
VAL L 135
 None
 0.89A 2aojA-5ockL:
undetectable		 2aojA-5ockL:
22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t2z PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
 None
 0.46A 2aojA-5t2zA:
20.1		 2aojA-5t2zA:
80.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te6 LIGHT CHAIN OF N6

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.91A 2aojA-5te6L:
undetectable		 2aojA-5te6L:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3n DH511.12P FAB LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.83A 2aojA-5u3nL:
undetectable		 2aojA-5u3nL:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3p DH511.4 FAB LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.84A 2aojA-5u3pL:
undetectable		 2aojA-5u3pL:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uem 354NC37 FAB LIGHT
CHAIN

(Homo sapiens) 		no annotation 4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.86A 2aojA-5uemL:
undetectable		 2aojA-5uemL:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5z 3C10 FAB LIGHT CHAIN

(Rattus
norvegicus) 		no annotation 4 LEU L 178
GLY L 127
PRO L 119
VAL L 131
 None
 0.90A 2aojA-5w5zL:
undetectable		 2aojA-5w5zL:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqw FAB FRAGMENT OF
CATALYTIC ANTIBODY
7B9, LIGHT CHAIN

(Mus musculus) 		no annotation 4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.90A 2aojA-5xqwL:
undetectable		 2aojA-5xqwL:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apb ADI-14359 FAB LIGHT
CHAIN

(Homo sapiens) 		no annotation 4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.87A 2aojA-6apbL:
undetectable		 2aojA-6apbL:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bb4 MOUSE MONOCLONAL
ANTIBODY C5.2 FAB
LIGHT CHAIN

(Mus musculus) 		no annotation 4 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.92A 2aojA-6bb4L:
undetectable		 2aojA-6bb4L:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6y JC57-14 LIGHT CHAIN

(Macaca mulatta) 		no annotation 4 LEU B 179
GLY B 128
PRO B 120
VAL B 132
 None
 0.83A 2aojA-6c6yB:
undetectable		 2aojA-6c6yB:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6upj HIV-2 PROTEASE

(Human
immunodeficiency
virus 2) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
 None
NIU  A 100 (-2.8A)
NIU  A 100 ( 3.8A)
None
 0.59A 2aojA-6upjA:
18.1		 2aojA-6upjA:
49.49