SIMILAR PATTERNS OF AMINO ACIDS FOR 2AOI_C_FRDC305_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ap8 TRANSLATION
INITIATION FACTOR
EIF4E

(Saccharomyces
cerevisiae) 		PF01652
(IF4E) 		4 ASP A 145
GLY A 179
VAL A 152
ILE A 149
 None
 0.84A 2aoiA-1ap8A:
undetectable		 2aoiA-1ap8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		4 ASP E 303
GLY E  34
VAL E 153
ILE E 306
 None
 0.91A 2aoiA-1cziE:
6.8		 2aoiA-1cziE:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 GLY A 194
PRO A 111
VAL A 109
ILE A 107
 None
 0.92A 2aoiA-1f4hA:
undetectable		 2aoiA-1f4hA:
6.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ASP A  25
GLY A  49
PRO A  81
VAL A  82
ILE A  84
 A79  A 800 (-2.7A)
A79  A 800 ( 3.7A)
A79  A 800 ( 3.9A)
A79  A 800 (-4.5A)
A79  A 800 (-3.6A)
 0.58A 2aoiA-1hvcA:
14.1		 2aoiA-1hvcA:
46.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ASP A  25
GLY A  49
PRO A  81
VAL A  82
ILE A  84
 A79  A 800 (-2.8A)
A79  A 800 (-3.4A)
A79  A 800 ( 3.4A)
A79  A 800 (-4.5A)
A79  A 800 (-3.8A)
 0.29A 2aoiA-1hvcA:
14.1		 2aoiA-1hvcA:
46.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 GLY A  48
PRO A  81
VAL A  82
ILE A  84
 A79  A 800 (-4.1A)
A79  A 800 ( 3.4A)
A79  A 800 (-4.5A)
A79  A 800 (-3.8A)
 0.91A 2aoiA-1hvcA:
14.1		 2aoiA-1hvcA:
46.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 GLY A 715
PRO A 739
VAL A 737
ILE A 707
 None
 0.92A 2aoiA-1l5jA:
undetectable		 2aoiA-1l5jA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrp PEPSIN 3A

(Homo sapiens) 		PF00026
(Asp) 		4 ASP E 303
GLY E  34
VAL E 153
ILE E 306
 None
HH0  E 327 (-4.1A)
None
None
 0.98A 2aoiA-1qrpE:
6.6		 2aoiA-1qrpE:
15.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		4 ASP A  25
GLY A  49
PRO A  81
ILE A  84
 None
 0.38A 2aoiA-1sivA:
18.5		 2aoiA-1sivA:
51.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzs CATHEPSIN E

(Homo sapiens) 		PF00026
(Asp) 		4 ASP A 319
GLY A  45
VAL A 164
ILE A 322
 None
 0.96A 2aoiA-1tzsA:
8.2		 2aoiA-1tzsA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2m HISTONE-LIKE PROTEIN
HLP-1

(Escherichia
coli) 		PF03938
(OmpH) 		4 ASP A 151
GLY A  30
VAL A 136
ILE A  26
 None
 1.00A 2aoiA-1u2mA:
undetectable		 2aoiA-1u2mA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd9 CORE HISTONE
MACRO-H2A.1

(Rattus
norvegicus) 		PF01661
(Macro) 		4 ASP A  27
GLY A  51
PRO A 133
VAL A 173
 None
 0.86A 2aoiA-1yd9A:
undetectable		 2aoiA-1yd9A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aoq DNA MISMATCH REPAIR
PROTEIN MUTH

(Haemophilus
influenzae) 		PF02976
(MutH) 		4 GLY A  49
PRO A  41
VAL A  40
ILE A  38
 None
 0.94A 2aoiA-2aoqA:
undetectable		 2aoiA-2aoqA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		4 ASP A 237
GLY A 211
VAL A 202
ILE A 216
 None
 0.97A 2aoiA-2bwgA:
undetectable		 2aoiA-2bwgA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzn GMP REDUCTASE 2

(Homo sapiens) 		PF00478
(IMPDH) 		4 ASP A 237
GLY A 211
VAL A 202
ILE A 216
 None
 1.00A 2aoiA-2bznA:
undetectable		 2aoiA-2bznA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 GLY A 308
PRO A 217
VAL A 220
ILE A 221
 None
 0.84A 2aoiA-2e3jA:
undetectable		 2aoiA-2e3jA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		4 GLY A  73
PRO A 168
VAL A 167
ILE A  29
 None
 0.89A 2aoiA-2f2aA:
undetectable		 2aoiA-2f2aA:
12.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		5 ASP A  25
GLY A  55
PRO A  86
VAL A  87
ILE A  89
 LP1  A 201 (-2.3A)
LP1  A 201 (-3.4A)
LP1  A 201 (-3.9A)
LP1  A 201 ( 4.9A)
LP1  A 201 (-4.2A)
 0.56A 2aoiA-2fmbA:
14.8		 2aoiA-2fmbA:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0f THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE

(Escherichia
coli) 		PF08534
(Redoxin) 		4 GLY A 139
PRO A  46
VAL A  45
ILE A 155
 None
 0.90A 2aoiA-2g0fA:
undetectable		 2aoiA-2g0fA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h39 PROBABLE
GALACTOSE-1-PHOSPHAT
E URIDYL TRANSFERASE

(Arabidopsis
thaliana) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		4 GLY A 144
PRO A 131
VAL A 132
ILE A 135
 None
 0.83A 2aoiA-2h39A:
undetectable		 2aoiA-2h39A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0o SER/THR PHOSPHATASE

(Anopheles
gambiae) 		PF00481
(PP2C) 		4 ASP A 479
GLY A 470
PRO A 445
ILE A 495
 None
 0.81A 2aoiA-2i0oA:
undetectable		 2aoiA-2i0oA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Thermotoga
maritima) 		PF01680
(SOR_SNZ) 		4 GLY A 134
PRO A 207
VAL A 208
ILE A 147
 None
 1.00A 2aoiA-2issA:
undetectable		 2aoiA-2issA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pth PEPTIDYL-TRNA
HYDROLASE

(Escherichia
coli) 		PF01195
(Pept_tRNA_hydro) 		4 ASP A  93
GLY A 151
PRO A 139
ILE A 136
 None
 0.97A 2aoiA-2pthA:
undetectable		 2aoiA-2pthA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 4 GLY A 165
PRO A 239
VAL A 258
ILE A 305
 None
 0.92A 2aoiA-2quaA:
undetectable		 2aoiA-2quaA:
9.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 ASP A  25
GLY A  49
PRO A  81
ILE A  84
 AB1  A 501 (-2.4A)
AB1  A 501 (-3.5A)
AB1  A 501 (-4.2A)
AB1  A 501 ( 4.2A)
 0.39A 2aoiA-2rkfA:
20.7		 2aoiA-2rkfA:
82.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y23 MYOMESIN

(Homo sapiens) 		PF07679
(I-set) 		4 ASP A1401
GLY A1409
VAL A1428
ILE A1389
 None
 0.75A 2aoiA-2y23A:
undetectable		 2aoiA-2y23A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4y PILP PROTEIN

(Pseudomonas
aeruginosa) 		PF04351
(PilP) 		4 ASP A 137
PRO A 155
VAL A 154
ILE A 153
 None
 0.97A 2aoiA-2y4yA:
undetectable		 2aoiA-2y4yA:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zdi PREFOLDIN SUBUNIT
ALPHA
PREFOLDIN SUBUNIT
BETA

(Pyrococcus
horikoshii) 		PF01920
(Prefoldin_2)
PF02996
(Prefoldin) 		4 GLY A  60
PRO C  65
VAL C  64
ILE C  62
 None
 0.96A 2aoiA-2zdiA:
undetectable		 2aoiA-2zdiA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 GLY A 368
PRO A  73
VAL A  72
ILE A  70
 None
 0.84A 2aoiA-3b1bA:
undetectable		 2aoiA-3b1bA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		4 GLY A 834
PRO A 779
VAL A 778
ILE A 776
 None
 1.00A 2aoiA-3bdlA:
undetectable		 2aoiA-3bdlA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		4 GLY A 118
PRO A  64
VAL A 269
ILE A 270
 PMP  A 431 (-3.6A)
None
None
None
 1.00A 2aoiA-3bs8A:
undetectable		 2aoiA-3bs8A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cne PUTATIVE PROTEASE I

(Bacteroides
thetaiotaomicron) 		PF01965
(DJ-1_PfpI) 		4 ASP A  92
GLY A  62
VAL A  56
ILE A  57
 None
 0.94A 2aoiA-3cneA:
undetectable		 2aoiA-3cneA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC

(Oryza sativa) 		no annotation 4 ASP O 291
GLY O 274
VAL O 279
ILE O 296
 None
 0.94A 2aoiA-3e6aO:
undetectable		 2aoiA-3e6aO:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 GLY A 155
PRO A 365
VAL A 368
ILE A 372
 None
 0.97A 2aoiA-3eb0A:
undetectable		 2aoiA-3eb0A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ele AMINO TRANSFERASE

([Eubacterium]
rectale) 		PF00155
(Aminotran_1_2) 		4 ASP A 330
PRO A 230
VAL A 229
ILE A 227
 None
 0.89A 2aoiA-3eleA:
undetectable		 2aoiA-3eleA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epf PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		4 GLY 2  93
PRO 2 268
VAL 2 267
ILE 2 265
 None
 0.97A 2aoiA-3epf2:
undetectable		 2aoiA-3epf2:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE

(Pseudomonas
putida) 		PF00180
(Iso_dh) 		4 GLY X 346
PRO X 117
VAL X 116
ILE X 335
 None
 0.86A 2aoiA-3fmxX:
undetectable		 2aoiA-3fmxX:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3b VARIABLE LYMPHOCYTE
RECEPTOR VLRB.2D

(Petromyzon
marinus) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		4 GLY A  17
PRO A  24
VAL A  23
ILE A  41
 None
 0.78A 2aoiA-3g3bA:
undetectable		 2aoiA-3g3bA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		4 ASP W 490
GLY W 520
VAL W 532
ILE W 533
 None
 0.99A 2aoiA-3iylW:
undetectable		 2aoiA-3iylW:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4y ISOPENTENYL
PHOSPHATE KINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase) 		4 GLY A  54
PRO A  61
VAL A  62
ILE A  86
 IPE  A 300 (-2.9A)
None
None
None
 0.94A 2aoiA-3k4yA:
undetectable		 2aoiA-3k4yA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF00356
(LacI)
PF00532
(Peripla_BP_1) 		4 GLY A  87
PRO A  99
VAL A  69
ILE A 127
 None
 0.67A 2aoiA-3kjxA:
undetectable		 2aoiA-3kjxA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7h PUTIDACIN L1

(Pseudomonas
putida) 		PF01453
(B_lectin) 		4 GLY A 224
PRO A 151
VAL A 229
ILE A 240
 None
 0.98A 2aoiA-3m7hA:
undetectable		 2aoiA-3m7hA:
14.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ASP A  25
GLY A  49
PRO A  81
VAL A  82
ILE A  84
 None
 0.41A 2aoiA-3mwsA:
20.3		 2aoiA-3mwsA:
79.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 GLY A  48
PRO A  81
VAL A  82
ILE A  84
 None
 0.98A 2aoiA-3mwsA:
20.3		 2aoiA-3mwsA:
79.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3og9 PROTEIN YAHD A
COPPER INDUCIBLE
HYDROLASE

(Lactococcus
lactis) 		PF01738
(DLH) 		4 GLY A  65
PRO A 161
VAL A 160
ILE A 159
 None
None
None
MLT  A 500 ( 4.6A)
 0.98A 2aoiA-3og9A:
undetectable		 2aoiA-3og9A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm8 CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF13499
(EF-hand_7) 		4 ASP A 482
GLY A 472
VAL A 464
ILE A 485
 None
 0.95A 2aoiA-3pm8A:
undetectable		 2aoiA-3pm8A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm9 PUTATIVE
OXIDOREDUCTASE

(Rhodopseudomonas
palustris) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 ASP A 315
GLY A 248
VAL A 318
ILE A 317
 None
 0.96A 2aoiA-3pm9A:
undetectable		 2aoiA-3pm9A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE

(Maricaulis
maris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		4 GLY A 129
PRO A  71
VAL A  73
ILE A 174
 None
 0.92A 2aoiA-3s6hA:
undetectable		 2aoiA-3s6hA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6c PUTATIVE MAND FAMILY
DEHYDRATASE

(Pantoea
ananatis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 342
PRO A 368
VAL A 377
ILE A 122
 None
 0.88A 2aoiA-3t6cA:
undetectable		 2aoiA-3t6cA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkk PREDICTED
ACETAMIDASE/FORMAMID
ASE

(Caldanaerobacter
subterraneus) 		PF03069
(FmdA_AmdA) 		4 GLY A 201
PRO A 130
VAL A 128
ILE A 113
 None
 0.95A 2aoiA-3tkkA:
undetectable		 2aoiA-3tkkA:
18.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 ASP A  25
GLY A  49
PRO A  81
ILE A  84
 017  A 201 (-2.6A)
017  A 201 (-3.0A)
017  A 201 (-4.1A)
017  A 201 (-4.7A)
 0.41A 2aoiA-3ttpA:
19.7		 2aoiA-3ttpA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvi ASPARTOKINASE

(Clostridium
acetobutylicum) 		PF00696
(AA_kinase)
PF01842
(ACT) 		4 GLY A 185
PRO A 252
VAL A 253
ILE A 250
 None
 0.89A 2aoiA-3tviA:
undetectable		 2aoiA-3tviA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PYRIDOXINE
BIOSYNTHETIC ENZYME
PDX1 HOMOLOGUE,
PUTATIVE

(Plasmodium
berghei) 		PF01680
(SOR_SNZ) 		4 GLY A 136
PRO A 209
VAL A 210
ILE A 149
 None
 0.85A 2aoiA-4adsA:
undetectable		 2aoiA-4adsA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4alq CHITIN BINDING
PROTEIN

(Enterococcus
faecalis) 		PF03067
(LPMO_10) 		4 ASP A 180
GLY A 177
PRO A 152
VAL A 151
 None
 0.87A 2aoiA-4alqA:
undetectable		 2aoiA-4alqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN

(Thermotoga
maritima) 		PF06964
(Alpha-L-AF_C) 		4 GLY A 274
PRO A 320
VAL A 319
ILE A 318
 None
 0.99A 2aoiA-4atwA:
undetectable		 2aoiA-4atwA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 GLY A 626
PRO A  47
VAL A  48
ILE A  45
 None
 0.95A 2aoiA-4byfA:
undetectable		 2aoiA-4byfA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1y PUTATIVE PROTEASE I

(Bacteroides
thetaiotaomicron) 		PF01965
(DJ-1_PfpI) 		4 ASP A  92
GLY A  62
VAL A  56
ILE A  57
 None
 0.81A 2aoiA-4d1yA:
undetectable		 2aoiA-4d1yA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg5 PHOSPHOGLYCERATE
KINASE

(Staphylococcus
aureus) 		PF00162
(PGK) 		4 ASP A 296
GLY A 319
VAL A 302
ILE A 297
 None
 0.91A 2aoiA-4dg5A:
undetectable		 2aoiA-4dg5A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 ASP A 131
GLY A 113
VAL A 143
ILE A 139
 None
 0.97A 2aoiA-4dykA:
undetectable		 2aoiA-4dykA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1

(Rhodopseudomonas
palustris) 		PF01590
(GAF)
PF08446
(PAS_2) 		4 GLY A  88
PRO A 216
VAL A 217
ILE A 248
 None
 0.84A 2aoiA-4e04A:
undetectable		 2aoiA-4e04A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ew5 CIGR PROTEIN

(Salmonella
enterica) 		no annotation 4 GLY A  87
PRO A 118
VAL A 117
ILE A 135
 None
 0.95A 2aoiA-4ew5A:
undetectable		 2aoiA-4ew5A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)

(Mycobacteroides
abscessus) 		PF00202
(Aminotran_3) 		4 GLY A 412
PRO A 389
VAL A 382
ILE A 381
 EDO  A 502 (-4.0A)
None
None
None
 0.95A 2aoiA-4ffcA:
undetectable		 2aoiA-4ffcA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fno PEPTIDYL-TRNA
HYDROLASE

(Pseudomonas
aeruginosa) 		PF01195
(Pept_tRNA_hydro) 		4 ASP A  95
GLY A 153
PRO A 141
ILE A 138
 None
 0.96A 2aoiA-4fnoA:
undetectable		 2aoiA-4fnoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gou EHRGS-RHOGEF

(Entamoeba
histolytica) 		PF00615
(RGS)
PF00621
(RhoGEF) 		4 GLY A 297
PRO A 304
VAL A 305
ILE A 221
 None
 0.75A 2aoiA-4gouA:
undetectable		 2aoiA-4gouA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0f LAMININ-BINDING
SURFACE PROTEIN

(Streptococcus
agalactiae) 		PF01297
(ZnuA) 		4 ASP A 140
GLY A 222
PRO A 228
ILE A 226
 None
 0.93A 2aoiA-4h0fA:
undetectable		 2aoiA-4h0fA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN

(Pseudomonas) 		PF01804
(Penicil_amidase) 		4 ASP B 232
GLY B 183
VAL B 230
ILE B 231
 None
 0.99A 2aoiA-4hstB:
undetectable		 2aoiA-4hstB:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Dickeya
paradisiaca) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 342
PRO A 368
VAL A 377
ILE A 122
 None
 0.92A 2aoiA-4ihcA:
undetectable		 2aoiA-4ihcA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Mycobacterium
tuberculosis) 		PF01680
(SOR_SNZ) 		4 GLY A 138
PRO A 211
VAL A 212
ILE A 151
 None
 0.88A 2aoiA-4jdyA:
undetectable		 2aoiA-4jdyA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR
HEPATOCYTE GROWTH
FACTOR BETA CHAIN

(Homo sapiens) 		PF00089
(Trypsin)
PF01403
(Sema)
PF01437
(PSI) 		4 ASP B 123
GLY A 696
VAL B 188
ILE B 193
 None
 0.88A 2aoiA-4k3jB:
undetectable		 2aoiA-4k3jB:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5u VARIABLE LYMPHOCYTE
RECEPTOR

(Petromyzon
marinus) 		no annotation 4 GLY B  18
PRO B  25
VAL B  24
ILE B  42
 None
 0.79A 2aoiA-4k5uB:
undetectable		 2aoiA-4k5uB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 GLY A  45
PRO A  52
VAL A  51
ILE A  69
 None
 0.87A 2aoiA-4kt1A:
undetectable		 2aoiA-4kt1A:
10.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 ASP A  25
GLY A  49
PRO A  81
ILE A  84
 RIT  A 500 (-2.4A)
RIT  A 500 (-3.4A)
RIT  A 500 (-3.9A)
RIT  A 500 (-4.3A)
 0.33A 2aoiA-4njvA:
20.9		 2aoiA-4njvA:
84.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p81 ANCESTRAL PYRR
PROTEIN (ORANGE)

(synthetic
construct) 		PF00156
(Pribosyltran) 		4 GLY A  39
PRO A  93
VAL A  94
ILE A  96
 None
 0.84A 2aoiA-4p81A:
undetectable		 2aoiA-4p81A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe3 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		4 ASP A 231
GLY A 197
PRO A 210
VAL A 192
 ZN  A 405 (-2.3A)
None
None
None
 1.00A 2aoiA-4pe3A:
undetectable		 2aoiA-4pe3A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B

(Danio rerio) 		PF06662
(C5-epim_C) 		4 ASP A 325
GLY A 308
VAL A 276
ILE A 289
 None
 0.91A 2aoiA-4pxqA:
undetectable		 2aoiA-4pxqA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 GLY A  45
PRO A  52
VAL A  51
ILE A  69
 None
 0.91A 2aoiA-4qxeA:
undetectable		 2aoiA-4qxeA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxf LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		4 GLY A  45
PRO A  52
VAL A  51
ILE A  69
 None
 0.83A 2aoiA-4qxfA:
undetectable		 2aoiA-4qxfA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		4 GLY A 206
PRO A 158
VAL A 157
ILE A 217
 None
 0.96A 2aoiA-4tpnA:
undetectable		 2aoiA-4tpnA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 ASP A 508
GLY A 422
VAL A 518
ILE A 520
 EDO  A 714 (-4.7A)
None
None
None
 0.77A 2aoiA-4wd1A:
undetectable		 2aoiA-4wd1A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		4 GLY A 137
PRO A 149
VAL A 148
ILE A 409
 None
 0.81A 2aoiA-4wj3A:
undetectable		 2aoiA-4wj3A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 GLY A 183
PRO A 250
VAL A 249
ILE A 291
 None
 1.00A 2aoiA-4xwhA:
undetectable		 2aoiA-4xwhA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bux 3-HYDROXYACYL-[ACYL-
CARRIER-PROTEIN]
DEHYDRATASE FABZ

(Yersinia pestis) 		PF07977
(FabA) 		4 GLY A  57
PRO A 107
VAL A 106
ILE A  60
 None
 1.00A 2aoiA-5buxA:
undetectable		 2aoiA-5buxA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa9 PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Treponema
denticola) 		PF01625
(PMSR)
PF01641
(SelR) 		4 GLY A 305
PRO A 218
VAL A 211
ILE A 294
 None
 0.97A 2aoiA-5fa9A:
undetectable		 2aoiA-5fa9A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3

(Arabidopsis
thaliana) 		PF01680
(SOR_SNZ) 		4 GLY A 149
PRO A 222
VAL A 223
ILE A 162
 None
None
EDO  A 406 (-4.6A)
None
 0.90A 2aoiA-5k2zA:
undetectable		 2aoiA-5k2zA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnt PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.1

(Arabidopsis
thaliana) 		PF01680
(SOR_SNZ) 		4 GLY A 150
PRO A 223
VAL A 224
ILE A 163
 None
 0.87A 2aoiA-5lntA:
undetectable		 2aoiA-5lntA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loi RAD26

(Thermothelomyces
thermophila) 		PF12331
(DUF3636) 		4 ASP A 439
PRO A 481
VAL A 482
ILE A 438
 None
 0.93A 2aoiA-5loiA:
undetectable		 2aoiA-5loiA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m9o STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		4 GLY A 859
PRO A 804
VAL A 803
ILE A 801
 None
 0.94A 2aoiA-5m9oA:
undetectable		 2aoiA-5m9oA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oki SISTER CHROMATID
COHESION PROTEIN
DCC1

(Saccharomyces
cerevisiae) 		no annotation 4 GLY C 175
PRO C 123
VAL C 122
ILE C 144
 None
 1.01A 2aoiA-5okiC:
undetectable		 2aoiA-5okiC:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t2z PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 ASP A  25
GLY A  49
PRO A  81
ILE A  84
 None
 0.43A 2aoiA-5t2zA:
20.1		 2aoiA-5t2zA:
80.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf4 UNCHARACTERIZED
PROTEIN

(Thermus
aquaticus) 		PF03781
(FGE-sulfatase) 		4 GLY A 251
PRO A 313
VAL A 312
ILE A 310
 None
 0.80A 2aoiA-5vf4A:
undetectable		 2aoiA-5vf4A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vl1 LYSINE--TRNA LIGASE

(Mycobacterium
ulcerans) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ASP A 435
GLY A 360
PRO A 387
VAL A 388
 None
 0.98A 2aoiA-5vl1A:
undetectable		 2aoiA-5vl1A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybw ASPARTATE RACEMASE

(Scapharca
broughtonii) 		no annotation 4 GLY A 245
PRO A 216
VAL A 270
ILE A 275
 LLP  A  63 ( 4.2A)
None
None
None
 0.98A 2aoiA-5ybwA:
undetectable		 2aoiA-5ybwA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a31 PEPTIDYL-TRNA
HYDROLASE

(Acinetobacter
baumannii) 		no annotation 4 ASP A  95
GLY A 151
PRO A 139
ILE A 136
 None
 1.00A 2aoiA-6a31A:
undetectable		 2aoiA-6a31A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6al7 12-EPI-HAPALINDOLE
C/U SYNTHASE

(Fischerella sp.
ATCC 43239) 		no annotation 4 ASP A 216
GLY A  83
VAL A  79
ILE A  99
 CA  A 302 (-2.4A)
None
None
None
 1.01A 2aoiA-6al7A:
undetectable		 2aoiA-6al7A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		no annotation 4 GLY A 355
PRO A 113
VAL A 114
ILE A 252
 None
SO4  A 405 (-3.8A)
None
None
 0.90A 2aoiA-6bacA:
undetectable		 2aoiA-6bacA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa VARIABLE LYMPHOCYTE
RECEPTOR 2

(Petromyzon
marinus) 		no annotation 4 GLY C  37
PRO C  44
VAL C  43
ILE C  61
 None
 0.78A 2aoiA-6bxaC:
undetectable		 2aoiA-6bxaC:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxe VARIABLE LYMPHOCYTE
RECEPTOR DIVERSITY
REGION

(Petromyzon
marinus) 		no annotation 4 GLY A  37
PRO A  44
VAL A  43
ILE A  61
 None
 0.78A 2aoiA-6bxeA:
undetectable		 2aoiA-6bxeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteichus
tenebrarius) 		no annotation 4 GLY B 221
PRO B 252
VAL B 253
ILE B 224
 None
None
MET  B 503 ( 4.9A)
None
 1.00A 2aoiA-6fd2B:
undetectable		 2aoiA-6fd2B:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpe TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE

(Thermotoga
maritima) 		no annotation 4 GLY B 161
PRO B 179
VAL B 180
ILE B 181
 PEG  B 402 ( 3.8A)
PEG  B 402 (-3.4A)
None
None
 0.93A 2aoiA-6fpeB:
undetectable		 2aoiA-6fpeB:
20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6upj HIV-2 PROTEASE

(Human
immunodeficiency
virus 2) 		PF00077
(RVP) 		4 ASP A  25
GLY A  49
PRO A  81
ILE A  84
 NIU  A 100 (-2.8A)
NIU  A 100 ( 3.8A)
None
None
 0.60A 2aoiA-6upjA:
18.1		 2aoiA-6upjA:
49.49