SIMILAR PATTERNS OF AMINO ACIDS FOR 2AOH_C_FRDC305_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d7b | CELLOBIOSEDEHYDROGENASE (Phanerochaetechrysosporium) |
PF16010(CDH-cyt) | 4 | ASP A 68GLY A 58PRO A 93ALA A 87 | NoneHEM A 401 (-3.5A)HEM A 401 (-4.5A)None | 0.68A | 2aohA-1d7bA:undetectable | 2aohA-1d7bA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fps | FARNESYL DIPHOSPHATESYNTHASE (Gallus gallus) |
PF00348(polyprenyl_synt) | 4 | LEU A 108GLY A 33PRO A 68ALA A 67 | None | 0.95A | 2aohA-1fpsA:undetectable | 2aohA-1fpsA:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hrd | GLUTAMATEDEHYDROGENASE ([Clostridium]symbiosum) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 4 | LEU A 166GLY A 134PRO A 96ALA A 95 | None | 0.95A | 2aohA-1hrdA:undetectable | 2aohA-1hrdA:14.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | LEU A 23ASP A 25GLY A 49PRO A 81 | A79 A 800 ( 4.0A)A79 A 800 (-2.8A)A79 A 800 (-3.4A)A79 A 800 ( 3.4A) | 0.40A | 2aohA-1hvcA:13.9 | 2aohA-1hvcA:46.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1knx | PROBABLE HPR(SER)KINASE/PHOSPHATASE (Mycoplasmapneumoniae) |
PF02603(Hpr_kinase_N)PF07475(Hpr_kinase_C) | 4 | LEU A 111GLY A 34PRO A 85ALA A 86 | None | 0.89A | 2aohA-1knxA:undetectable | 2aohA-1knxA:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ktn | 2-DEOXYRIBOSE-5-PHOSPHATE ALDOLASE (Escherichiacoli) |
PF01791(DeoC) | 4 | ASP A 102GLY A 199PRO A 202ALA A 203 | None | 0.97A | 2aohA-1ktnA:undetectable | 2aohA-1ktnA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lf9 | GLUCOAMYLASE (Thermoanaerobacteriumthermosaccharolyticum) |
PF00723(Glyco_hydro_15)PF09137(Glucodextran_N) | 4 | LEU A 652GLY A 582PRO A 324ALA A 649 | None | 0.71A | 2aohA-1lf9A:undetectable | 2aohA-1lf9A:10.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mlz | 7,8-DIAMINO-PELARGONIC ACIDAMINOTRANSFERASE (Escherichiacoli) |
PF00202(Aminotran_3) | 4 | LEU A 37ASP A 47GLY A 279ALA A 32 | None | 0.92A | 2aohA-1mlzA:undetectable | 2aohA-1mlzA:13.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nkv | HYPOTHETICAL PROTEINYJHP (Escherichiacoli) |
PF13847(Methyltransf_31) | 4 | LEU A 186GLY A 111PRO A 19ALA A 187 | None | 0.97A | 2aohA-1nkvA:undetectable | 2aohA-1nkvA:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1po0 | IRON(III) DICITRATETRANSPORT PROTEINFECA PRECURSOR (Escherichiacoli) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 4 | LEU A 124GLY A 151PRO A 133ALA A 132 | None | 0.97A | 2aohA-1po0A:undetectable | 2aohA-1po0A:11.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qqe | VESICULAR TRANSPORTPROTEIN SEC17 (Saccharomycescerevisiae) |
PF14938(SNAP) | 4 | LEU A 61ASP A 58GLY A 90ALA A 83 | None | 0.86A | 2aohA-1qqeA:undetectable | 2aohA-1qqeA:19.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 4 | LEU A 23ASP A 25GLY A 49PRO A 81 | None | 0.60A | 2aohA-1sivA:18.6 | 2aohA-1sivA:51.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1te5 | CONSERVEDHYPOTHETICAL PROTEIN (Pseudomonasaeruginosa) |
PF13230(GATase_4) | 4 | LEU A 54ASP A 35GLY A 28PRO A 32 | None | 0.93A | 2aohA-1te5A:undetectable | 2aohA-1te5A:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ulv | GLUCODEXTRANASE (Arthrobacterglobiformis) |
PF00723(Glyco_hydro_15)PF09136(Glucodextran_B)PF09137(Glucodextran_N)PF09985(Glucodextran_C) | 4 | LEU A 653GLY A 574PRO A 312ALA A 650 | None | 0.77A | 2aohA-1ulvA:undetectable | 2aohA-1ulvA:7.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wcx | UROPORPHYRINOGEN IIISYNTHASE (Thermusthermophilus) |
PF02602(HEM4) | 4 | LEU A 187GLY A 222PRO A 236ALA A 218 | None | 0.93A | 2aohA-1wcxA:undetectable | 2aohA-1wcxA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wqa | PHOSPHO-SUGAR MUTASE (Pyrococcushorikoshii) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 4 | LEU A 310ASP A 309GLY A 330ALA A 313 | LEU A 310 ( 0.6A)ASP A 309 ( 0.5A)GLY A 330 ( 0.0A)ALA A 313 ( 0.0A) | 0.90A | 2aohA-1wqaA:undetectable | 2aohA-1wqaA:14.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wyt | GLYCINEDEHYDROGENASESUBUNIT 2(P-PROTEIN) (Thermusthermophilus) |
PF02347(GDC-P) | 4 | LEU B 445GLY B 398PRO B 449ALA B 448 | None | 0.85A | 2aohA-1wytB:undetectable | 2aohA-1wytB:11.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2am2 | UDP-N-ACETYLMURAMOYLALANINE-D-GLUTAMYL-LYSINE-D-ALANYL-D-ALANINE LIGASE, MURFPROTEIN (Streptococcuspneumoniae) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 4 | LEU A 215GLY A 107PRO A 218ALA A 217 | None | 0.88A | 2aohA-2am2A:undetectable | 2aohA-2am2A:11.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cwj | PUTATIVEENDONUCLEASE (Aeropyrumpernix) |
PF01042(Ribonuc_L-PSP) | 4 | LEU A 49GLY A 40PRO A 28ALA A 48 | None | 0.92A | 2aohA-2cwjA:undetectable | 2aohA-2cwjA:22.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 4 | LEU A 23ASP A 25GLY A 55PRO A 86 | NoneLP1 A 201 (-2.3A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A) | 0.48A | 2aohA-2fmbA:15.0 | 2aohA-2fmbA:33.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g17 | N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Salmonellaenterica) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 4 | LEU A 310ASP A 307GLY A 188ALA A 314 | None | 0.92A | 2aohA-2g17A:undetectable | 2aohA-2g17A:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gko | SUBTILISINMICROBIAL SERINEPROTEINASES (Bacillussubtilis) |
PF00082(Peptidase_S8) | 4 | LEU A 288ASP A 286GLY A 215ALA A 293 | None CA A 612 (-3.1A)NoneNone | 0.97A | 2aohA-2gkoA:undetectable | 2aohA-2gkoA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gz3 | ASPARTATEBETA-SEMIALDEHYDEDEHYDROGENASE (Streptococcuspneumoniae) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 4 | LEU A 327ASP A 324GLY A 159ALA A 331 | NoneNoneNAP A 367 ( 3.1A)None | 0.90A | 2aohA-2gz3A:undetectable | 2aohA-2gz3A:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n0s | FE-HYDROGENASE (Chlamydomonasreinhardtii) |
PF02256(Fe_hyd_SSU)PF02906(Fe_hyd_lg_C) | 4 | LEU A 91ASP A 89PRO A 154ALA A 94 | None | 0.94A | 2aohA-2n0sA:undetectable | 2aohA-2n0sA:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pby | GLUTAMINASE (Geobacilluskaustophilus) |
PF04960(Glutaminase) | 5 | LEU A 290ASP A 284GLY A 261PRO A 281ALA A 282 | None | 1.36A | 2aohA-2pbyA:undetectable | 2aohA-2pbyA:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q0o | PROBABLETRANSCRIPTIONALACTIVATOR PROTEINTRAR (Sinorhizobiumfredii) |
PF00196(GerE)PF03472(Autoind_bind) | 4 | LEU A 75ASP A 72GLY A 115ALA A 78 | NoneLAE A1001 (-3.0A)NoneNone | 0.70A | 2aohA-2q0oA:undetectable | 2aohA-2q0oA:17.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | LEU A 23ASP A 25GLY A 49PRO A 81ALA A 82 | NoneAB1 A 501 (-2.4A)AB1 A 501 (-3.5A)AB1 A 501 (-4.2A)AB1 A 501 (-3.6A) | 0.43A | 2aohA-2rkfA:20.8 | 2aohA-2rkfA:83.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdc | GLUTAMATE SYNTHASE[NADPH] SMALL CHAIN (Azospirillumbrasilense) |
PF07992(Pyr_redox_2)PF14691(Fer4_20) | 4 | LEU G 262ASP G 263GLY G 252ALA G 245 | None | 0.97A | 2aohA-2vdcG:undetectable | 2aohA-2vdcG:13.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3brq | HTH-TYPETRANSCRIPTIONALREGULATOR ASCG (Escherichiacoli) |
PF13377(Peripla_BP_3) | 4 | LEU A 20GLY A 270PRO A 101ALA A 78 | None | 0.80A | 2aohA-3brqA:undetectable | 2aohA-3brqA:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d8n | UROPORPHYRINOGEN-IIISYNTHASE (Thermusthermophilus) |
PF02602(HEM4) | 4 | LEU A 179GLY A 214PRO A 228ALA A 210 | None | 0.87A | 2aohA-3d8nA:undetectable | 2aohA-3d8nA:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dpr | PROTEIN VP2PROTEIN VP3 (Rhinovirus A) |
PF00073(Rhv) | 4 | LEU B 126GLY C 38PRO B 205ALA B 204 | None | 0.97A | 2aohA-3dprB:undetectable | 2aohA-3dprB:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3emy | TRICHODERMA REESEIASPARTIC PROTEASE (Trichodermareesei) |
PF00026(Asp) | 4 | LEU A 155ASP A 304GLY A 34ALA A 153 | None | 0.88A | 2aohA-3emyA:6.6 | 2aohA-3emyA:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i8o | KH DOMAIN-CONTAININGPROTEIN MJ1533 (Methanocaldococcusjannaschii) |
PF01850(PIN) | 4 | LEU A 132ASP A 32GLY A 115ALA A 143 | None | 0.96A | 2aohA-3i8oA:undetectable | 2aohA-3i8oA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iml | S-ADENOSYLMETHIONINESYNTHETASE (Burkholderiapseudomallei) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 4 | LEU A 29ASP A 26GLY A 247ALA A 43 | None | 0.83A | 2aohA-3imlA:undetectable | 2aohA-3imlA:14.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j09 | COPPER-EXPORTINGP-TYPE ATPASE A (Archaeoglobusfulgidus) |
PF00122(E1-E2_ATPase)PF00403(HMA)PF00702(Hydrolase) | 4 | ASP A 424GLY A 277PRO A 624ALA A 625 | None | 0.78A | 2aohA-3j09A:undetectable | 2aohA-3j09A:8.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kfu | NON-DISCRIMINATINGAND ARCHAEAL-TYPEASPARTYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 4 | LEU A 255GLY A 403PRO A 124ALA A 123 | None | 0.83A | 2aohA-3kfuA:undetectable | 2aohA-3kfuA:13.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l7y | PUTATIVEUNCHARACTERIZEDPROTEIN SMU.1108C (Streptococcusmutans) |
PF08282(Hydrolase_3) | 4 | ASP A 9GLY A 182PRO A 239ALA A 238 | MG A 271 (-2.9A)NoneNoneNone | 0.95A | 2aohA-3l7yA:undetectable | 2aohA-3l7yA:15.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lrk | ALPHA-GALACTOSIDASE1 (Saccharomycescerevisiae) |
PF16499(Melibiase_2) | 4 | LEU A 439ASP A 436GLY A 418ALA A 310 | NoneNoneNoneGOL A7003 (-3.6A) | 0.89A | 2aohA-3lrkA:undetectable | 2aohA-3lrkA:12.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lye | OXALOACETATE ACETYLHYDROLASE (Cryphonectriaparasitica) |
PF13714(PEP_mutase) | 4 | ASP A 95GLY A 92PRO A 314ALA A 315 | None | 0.91A | 2aohA-3lyeA:undetectable | 2aohA-3lyeA:15.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m6x | RRNA METHYLASE (Thermusthermophilus) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N)PF17126(RsmF_methylt_CI) | 4 | LEU A 358GLY A 136PRO A 361ALA A 360 | None | 0.97A | 2aohA-3m6xA:undetectable | 2aohA-3m6xA:12.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | LEU A 23ASP A 25GLY A 49PRO A 81 | None | 0.28A | 2aohA-3mwsA:20.3 | 2aohA-3mwsA:78.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oa2 | WBPB (Pseudomonasaeruginosa) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | ASP A 33GLY A 39PRO A 15ALA A 14 | NAD A 317 (-2.7A)NoneNoneNone | 0.95A | 2aohA-3oa2A:undetectable | 2aohA-3oa2A:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ooq | AMIDOHYDROLASE (Thermotogamaritima) |
PF01979(Amidohydro_1) | 4 | ASP A 232GLY A 174PRO A 124ALA A 153 | None | 0.97A | 2aohA-3ooqA:undetectable | 2aohA-3ooqA:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pnz | PHOSPHOTRIESTERASEFAMILY PROTEIN (Listeriamonocytogenes) |
PF02126(PTE) | 4 | LEU A 40ASP A 39GLY A 285ALA A 274 | NoneNoneNonePO4 A 336 ( 4.3A) | 0.88A | 2aohA-3pnzA:undetectable | 2aohA-3pnzA:15.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pzr | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Vibrio cholerae) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 4 | LEU A 352ASP A 349GLY A 165ALA A 356 | NoneNoneCYS A 371 (-3.4A)None | 0.95A | 2aohA-3pzrA:undetectable | 2aohA-3pzrA:14.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t33 | G PROTEIN COUPLEDRECEPTOR (Arabidopsisthaliana) |
PF05147(LANC_like) | 4 | LEU A 149ASP A 146GLY A 140ALA A 133 | None | 0.96A | 2aohA-3t33A:undetectable | 2aohA-3t33A:15.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | LEU A 23ASP A 25GLY A 49PRO A 81ALA A 82 | SO4 A 101 (-4.2A)017 A 201 (-2.6A)017 A 201 (-4.0A)NoneSO4 A 101 (-3.5A) | 0.55A | 2aohA-3t3cA:18.8 | 2aohA-3t3cA:75.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | LEU A 23ASP A 25GLY A 49PRO A 81 | None017 A 201 (-2.6A)017 A 201 (-3.0A)017 A 201 (-4.1A) | 0.40A | 2aohA-3ttpA:19.8 | 2aohA-3ttpA:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u1k | POLYRIBONUCLEOTIDENUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL (Homo sapiens) |
PF00013(KH_1)PF01138(RNase_PH)PF03725(RNase_PH_C)PF03726(PNPase) | 4 | LEU A 513ASP A 542GLY A 522PRO A 567 | None | 0.88A | 2aohA-3u1kA:undetectable | 2aohA-3u1kA:10.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | LEU A 23ASP A 25GLY A 49PRO A 81 | None017 A 202 ( 2.5A)017 A 202 (-2.9A)017 A 202 (-4.0A) | 0.40A | 2aohA-3u7sA:20.2 | 2aohA-3u7sA:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uw3 | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Burkholderiathailandensis) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 4 | LEU A 356ASP A 353GLY A 165ALA A 360 | None | 0.93A | 2aohA-3uw3A:undetectable | 2aohA-3uw3A:13.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wjp | HYDROGENASEEXPRESSION/FORMATIONPROTEIN HYPE (Thermococcuskodakarensis) |
PF00586(AIRS)PF02769(AIRS_C) | 4 | LEU A 231GLY A 174PRO A 222ALA A 230 | None | 0.96A | 2aohA-3wjpA:undetectable | 2aohA-3wjpA:14.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bzi | SEC23P (Saccharomycescerevisiae) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 4 | LEU A 371ASP A 604GLY A 292ALA A 347 | None | 0.94A | 2aohA-4bziA:undetectable | 2aohA-4bziA:9.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c2k | 3-KETOACYL-COATHIOLASE,MITOCHONDRIAL (Homo sapiens) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 4 | ASP A 180GLY A 243PRO A 325ALA A 324 | None | 0.91A | 2aohA-4c2kA:undetectable | 2aohA-4c2kA:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hjh | PHOSPHOMANNOMUTASE (Brucellamelitensis) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 4 | LEU A 156GLY A 243PRO A 85ALA A 86 | NoneSEP A 104 ( 4.6A)NoneNone | 0.69A | 2aohA-4hjhA:undetectable | 2aohA-4hjhA:11.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ix1 | HYPOTHETICAL PROTEIN (Rhodococcusopacus) |
no annotation | 4 | LEU A 30GLY A 244PRO A 35ALA A 34 | None | 0.96A | 2aohA-4ix1A:undetectable | 2aohA-4ix1A:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jkw | BUTYROPHILINSUBFAMILY 3 MEMBERA1 (Homo sapiens) |
PF07686(V-set) | 4 | LEU A 73ASP A 75PRO A 24ALA A 83 | None | 0.92A | 2aohA-4jkwA:undetectable | 2aohA-4jkwA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ljp | E3 UBIQUITIN-PROTEINLIGASE RNF31 (Homo sapiens) |
no annotation | 4 | LEU A1057GLY A1064PRO A1017ALA A1018 | None | 0.80A | 2aohA-4ljpA:undetectable | 2aohA-4ljpA:15.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lrs | ACETALDEHYDEDEHYDROGENASE (Thermomonosporacurvata) |
PF01118(Semialdhyde_dh)PF09290(AcetDehyd-dimer) | 4 | LEU B 101GLY B 181PRO B 119ALA B 120 | NonePEG B 409 ( 3.5A)NAD B 401 (-4.8A)None | 0.93A | 2aohA-4lrsB:undetectable | 2aohA-4lrsB:14.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | LEU A 23ASP A 25GLY A 49PRO A 81 | NoneRIT A 500 (-2.4A)RIT A 500 (-3.4A)RIT A 500 (-3.9A) | 0.53A | 2aohA-4njvA:21.1 | 2aohA-4njvA:84.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1i | TRANSCRIPTIONALREGULATORY PROTEIN (Mycobacteriumtuberculosis) |
no annotation | 4 | LEU A 4GLY A 113PRO A 72ALA A 45 | None | 0.96A | 2aohA-4o1iA:undetectable | 2aohA-4o1iA:25.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2c | CRISPR-ASSOCIATEDHELICASE CAS3 (Thermobaculumterrenum) |
PF00271(Helicase_C) | 4 | LEU A 660ASP A 626GLY A 938ALA A 662 | None | 0.93A | 2aohA-4q2cA:undetectable | 2aohA-4q2cA:7.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q7a | N-ACETYL-ORNITHINE/N-ACETYL-LYSINEDEACETYLASE (Sphaerobacterthermophilus) |
PF01546(Peptidase_M20) | 4 | ASP A 328GLY A 154PRO A 99ALA A 96 | SO4 A 401 ( 4.6A)NoneNoneNone | 0.93A | 2aohA-4q7aA:undetectable | 2aohA-4q7aA:14.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r27 | GLYCOSIDE HYDROLASE (Microbacteriumsp. Gsoil167) |
PF00232(Glyco_hydro_1) | 4 | LEU A 46ASP A 42GLY A 138ALA A 201 | None | 0.96A | 2aohA-4r27A:undetectable | 2aohA-4r27A:13.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w1w | ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE (Mycobacteriumtuberculosis) |
PF00202(Aminotran_3) | 4 | LEU A 46ASP A 59GLY A 288ALA A 41 | None | 0.85A | 2aohA-4w1wA:undetectable | 2aohA-4w1wA:14.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wep | PUTATIVEOSMOPROTECTANTUPTAKE SYSTEMSUBSTRATE-BINDINGPROTEIN OSMF (Escherichiacoli) |
PF04069(OpuAC) | 4 | ASP A 272GLY A 220PRO A 245ALA A 124 | None | 0.95A | 2aohA-4wepA:undetectable | 2aohA-4wepA:15.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4woj | ASPARTATESEMIALDEHYDEDEHYDROGENASE (Francisellatularensis) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 4 | LEU A 348ASP A 345GLY A 166ALA A 352 | None | 0.88A | 2aohA-4wojA:undetectable | 2aohA-4wojA:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yhs | MONOSACCHARIDE ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN, CUT2 FAMILY (Bradyrhizobiumsp. BTAi1) |
PF13407(Peripla_BP_4) | 4 | LEU A 60GLY A 315PRO A 142ALA A 118 | None | 0.89A | 2aohA-4yhsA:undetectable | 2aohA-4yhsA:12.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yn2 | FUSOLIN (unidentifiedentomopoxvirus) |
PF03067(LPMO_10) | 4 | LEU A 45ASP A 42GLY A 25ALA A 54 | None | 0.94A | 2aohA-4yn2A:undetectable | 2aohA-4yn2A:15.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bnt | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Pseudomonasaeruginosa) |
no annotation | 4 | LEU C 353ASP C 350GLY C 166ALA C 357 | None | 0.97A | 2aohA-5bntC:undetectable | 2aohA-5bntC:15.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwd | BENZYLSUCCINATESYNTHASE ALPHA CHAIN (Thaueraaromatica) |
PF01228(Gly_radical)PF02901(PFL-like) | 4 | ASP A 733GLY A 706PRO A 517ALA A 518 | None | 0.75A | 2aohA-5bwdA:undetectable | 2aohA-5bwdA:8.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwi | GLYCOSIDE HYDROLASEFAMILY 79 (Burkholderiapseudomallei) |
PF12891(Glyco_hydro_44) | 4 | LEU A 275GLY A 266PRO A 319ALA A 274 | None | 0.90A | 2aohA-5bwiA:undetectable | 2aohA-5bwiA:13.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c2i | ALR1585 PROTEIN (Nostoc sp. PCC7120) |
PF04261(Dyp_perox) | 4 | LEU A 255GLY A 103PRO A 460ALA A 459 | None | 0.96A | 2aohA-5c2iA:undetectable | 2aohA-5c2iA:14.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5djs | TETRATRICOPEPTIDETPR_2 REPEAT PROTEIN (Thermobaculumterrenum) |
PF13181(TPR_8)PF13844(Glyco_transf_41) | 4 | LEU A 354GLY A 474PRO A 331ALA A 360 | None | 0.89A | 2aohA-5djsA:undetectable | 2aohA-5djsA:10.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epe | SAM-DEPENDENTMETHYLTRANSFERASE (Thiobacillusdenitrificans) |
PF13847(Methyltransf_31) | 4 | LEU A 186GLY A 111PRO A 19ALA A 187 | NoneSAH A 301 (-4.9A)NoneNone | 0.96A | 2aohA-5epeA:undetectable | 2aohA-5epeA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g10 | HDAH (Pseudomonasaeruginosa) |
PF00850(Hist_deacetyl) | 4 | LEU A 75ASP A 72PRO A 69ALA A 70 | None | 0.98A | 2aohA-5g10A:undetectable | 2aohA-5g10A:13.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hct | ENDOTHIAPEPSIN (Cryphonectriaparasitica) |
PF00026(Asp) | 4 | LEU A 161ASP A 307GLY A 37ALA A 159 | NoneNone61P A 406 ( 4.0A)None | 0.89A | 2aohA-5hctA:7.3 | 2aohA-5hctA:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5im5 | DESIGNEDKETO-HYDROXYGLUTARATE-ALDOLASE/KETO-DEOXY-PHOSPHOGLUCONATEALDOLASE (VibrionalesbacteriumSWAT-3) |
no annotation | 4 | LEU P 56GLY P 36PRO P 15ALA P 40 | None | 0.96A | 2aohA-5im5P:undetectable | 2aohA-5im5P:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kf4 | COLLAGEN ALPHA-1(XX)CHAIN (Homo sapiens) |
PF00041(fn3) | 4 | LEU A 377GLY A 426PRO A 380ALA A 379 | None | 0.92A | 2aohA-5kf4A:undetectable | 2aohA-5kf4A:16.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nof | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Thermococcuskodakarensis) |
no annotation | 4 | LEU A 66GLY A 103PRO A 177ALA A 178 | None | 0.90A | 2aohA-5nofA:undetectable | 2aohA-5nofA:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o96 | RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE E (Legionellapneumophila) |
no annotation | 4 | ASP A 203GLY A 200PRO A 175ALA A 176 | NoneSAM A 501 (-2.9A)SAM A 501 (-3.4A)None | 0.78A | 2aohA-5o96A:undetectable | 2aohA-5o96A:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5p60 | ENDOTHIAPEPSIN (Cryphonectriaparasitica) |
PF00026(Asp) | 4 | LEU A 161ASP A 307GLY A 37ALA A 159 | None | 0.88A | 2aohA-5p60A:7.3 | 2aohA-5p60A:15.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5swi | SUGAR HYDROLASE (Streptococcuspneumoniae) |
no annotation | 4 | LEU B 212GLY B 34PRO B 125ALA B 130 | None | 0.91A | 2aohA-5swiB:undetectable | 2aohA-5swiB:9.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | LEU A 23ASP A 25GLY A 49PRO A 81 | None | 0.51A | 2aohA-5t2zA:20.2 | 2aohA-5t2zA:80.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t8t | S-ADENOSYLMETHIONINESYNTHASE (Neisseriagonorrhoeae) |
PF00438(S-AdoMet_synt_N)PF02772(S-AdoMet_synt_M)PF02773(S-AdoMet_synt_C) | 4 | LEU A 28ASP A 25GLY A 248ALA A 42 | None | 0.84A | 2aohA-5t8tA:undetectable | 2aohA-5t8tA:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ti8 | AMINOTRANSFERASE (Pseudomonas sp.M1) |
PF00202(Aminotran_3) | 4 | LEU A 46ASP A 56GLY A 295ALA A 41 | None | 0.95A | 2aohA-5ti8A:undetectable | 2aohA-5ti8A:13.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tjr | METHYLMALONATE-SEMIALDEHYDEDEHYDROGENASE (Pseudomonas sp.AAC) |
PF00171(Aldedh) | 4 | LEU A 101GLY A 91PRO A 151ALA A 152 | None | 0.88A | 2aohA-5tjrA:undetectable | 2aohA-5tjrA:10.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u39 | UDP-3-O-ACYL-N-ACETYLGLUCOSAMINEDEACETYLASE (Pseudomonasaeruginosa) |
PF03331(LpxC) | 4 | LEU A 240ASP A 241GLY A 192ALA A 188 | None ZN A 501 ( 2.0A)C90 A 502 ( 4.5A)None | 0.90A | 2aohA-5u39A:undetectable | 2aohA-5u39A:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uc7 | ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE (environmentalsamples) |
PF00202(Aminotran_3) | 4 | LEU A 37ASP A 47GLY A 279ALA A 32 | NoneNoneLLP A 274 ( 4.1A)None | 0.94A | 2aohA-5uc7A:undetectable | 2aohA-5uc7A:13.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wgc | DAUNORUBICIN-DOXORUBICIN POLYKETIDESYNTHASE (Streptomycespeucetius) |
no annotation | 4 | LEU A 298ASP A 302GLY A 268ALA A 166 | None | 0.97A | 2aohA-5wgcA:undetectable | 2aohA-5wgcA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wqn | PROBABLEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00106(adh_short) | 4 | ASP A 58GLY A 8PRO A 113ALA A 112 | None | 0.92A | 2aohA-5wqnA:undetectable | 2aohA-5wqnA:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x2q | TASTE RECEPTOR, TYPE1, MEMBER 2A (Oryzias latipes) |
PF01094(ANF_receptor) | 4 | LEU A 431ASP A 289GLY A 217ALA A 191 | None | 0.88A | 2aohA-5x2qA:undetectable | 2aohA-5x2qA:11.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x9r | CITRATE-SODIUMSYMPORTER (Klebsiellapneumoniae) |
PF03390(2HCT) | 4 | LEU A 375GLY A 234PRO A 388ALA A 378 | None | 0.80A | 2aohA-5x9rA:undetectable | 2aohA-5x9rA:13.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xoy | [LYSW]-LYSINEHYDROLASE (Thermusthermophilus) |
PF01546(Peptidase_M20) | 4 | ASP A 325GLY A 151PRO A 95ALA A 92 | None | 0.91A | 2aohA-5xoyA:undetectable | 2aohA-5xoyA:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | 40S RIBOSOMALPROTEIN S2140S RIBOSOMALPROTEIN SA (Trichomonasvaginalis) |
PF00318(Ribosomal_S2)PF01249(Ribosomal_S21e) | 4 | LEU V 68ASP A 156GLY V 56ALA V 67 | None | 0.70A | 2aohA-5xyiV:undetectable | 2aohA-5xyiV:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y7r | IRON/ALPHA-KETOGLUTARATE-DEPENDENTDIOXYGENASE ASQJ (Aspergillusnidulans) |
no annotation | 4 | LEU B 204GLY B 177PRO B 12ALA B 33 | None | 0.96A | 2aohA-5y7rB:undetectable | 2aohA-5y7rB:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bac | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Neisseriagonorrhoeae) |
no annotation | 4 | LEU A 353ASP A 350GLY A 166ALA A 357 | None | 0.95A | 2aohA-6bacA:undetectable | 2aohA-6bacA:13.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bcq | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY MMEMBER 4 (Mus musculus) |
no annotation | 4 | LEU B 395ASP B 396GLY B 387ALA B 391 | None | 0.90A | 2aohA-6bcqB:undetectable | 2aohA-6bcqB:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6egt | GLYCOPROTEIN (Rift Valleyfeverphlebovirus) |
no annotation | 4 | LEU A1034ASP A1081GLY A1078ALA A1032 | NAG A1302 ( 4.4A)NAG A1302 (-3.5A)FUL A1304 ( 4.2A)None | 0.97A | 2aohA-6egtA:undetectable | 2aohA-6egtA:12.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 4 | LEU A 23ASP A 25GLY A 49PRO A 81 | NoneNIU A 100 (-2.8A)NIU A 100 ( 3.8A)None | 0.58A | 2aohA-6upjA:18.2 | 2aohA-6upjA:49.49 |