SIMILAR PATTERNS OF AMINO ACIDS FOR 2AOH_C_FRDC305_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7b CELLOBIOSE
DEHYDROGENASE


(Phanerochaete
chrysosporium)
PF16010
(CDH-cyt)
4 ASP A  68
GLY A  58
PRO A  93
ALA A  87
None
HEM  A 401 (-3.5A)
HEM  A 401 (-4.5A)
None
0.68A 2aohA-1d7bA:
undetectable
2aohA-1d7bA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE


(Gallus gallus)
PF00348
(polyprenyl_synt)
4 LEU A 108
GLY A  33
PRO A  68
ALA A  67
None
0.95A 2aohA-1fpsA:
undetectable
2aohA-1fpsA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hrd GLUTAMATE
DEHYDROGENASE


([Clostridium]
symbiosum)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 LEU A 166
GLY A 134
PRO A  96
ALA A  95
None
0.95A 2aohA-1hrdA:
undetectable
2aohA-1hrdA:
14.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
A79  A 800 ( 4.0A)
A79  A 800 (-2.8A)
A79  A 800 (-3.4A)
A79  A 800 ( 3.4A)
0.40A 2aohA-1hvcA:
13.9
2aohA-1hvcA:
46.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knx PROBABLE HPR(SER)
KINASE/PHOSPHATASE


(Mycoplasma
pneumoniae)
PF02603
(Hpr_kinase_N)
PF07475
(Hpr_kinase_C)
4 LEU A 111
GLY A  34
PRO A  85
ALA A  86
None
0.89A 2aohA-1knxA:
undetectable
2aohA-1knxA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE


(Escherichia
coli)
PF01791
(DeoC)
4 ASP A 102
GLY A 199
PRO A 202
ALA A 203
None
0.97A 2aohA-1ktnA:
undetectable
2aohA-1ktnA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum)
PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N)
4 LEU A 652
GLY A 582
PRO A 324
ALA A 649
None
0.71A 2aohA-1lf9A:
undetectable
2aohA-1lf9A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE


(Escherichia
coli)
PF00202
(Aminotran_3)
4 LEU A  37
ASP A  47
GLY A 279
ALA A  32
None
0.92A 2aohA-1mlzA:
undetectable
2aohA-1mlzA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkv HYPOTHETICAL PROTEIN
YJHP


(Escherichia
coli)
PF13847
(Methyltransf_31)
4 LEU A 186
GLY A 111
PRO A  19
ALA A 187
None
0.97A 2aohA-1nkvA:
undetectable
2aohA-1nkvA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR


(Escherichia
coli)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
4 LEU A 124
GLY A 151
PRO A 133
ALA A 132
None
0.97A 2aohA-1po0A:
undetectable
2aohA-1po0A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqe VESICULAR TRANSPORT
PROTEIN SEC17


(Saccharomyces
cerevisiae)
PF14938
(SNAP)
4 LEU A  61
ASP A  58
GLY A  90
ALA A  83
None
0.86A 2aohA-1qqeA:
undetectable
2aohA-1qqeA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus)
PF00077
(RVP)
4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
None
0.60A 2aohA-1sivA:
18.6
2aohA-1sivA:
51.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te5 CONSERVED
HYPOTHETICAL PROTEIN


(Pseudomonas
aeruginosa)
PF13230
(GATase_4)
4 LEU A  54
ASP A  35
GLY A  28
PRO A  32
None
0.93A 2aohA-1te5A:
undetectable
2aohA-1te5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis)
PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C)
4 LEU A 653
GLY A 574
PRO A 312
ALA A 650
None
0.77A 2aohA-1ulvA:
undetectable
2aohA-1ulvA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE


(Thermus
thermophilus)
PF02602
(HEM4)
4 LEU A 187
GLY A 222
PRO A 236
ALA A 218
None
0.93A 2aohA-1wcxA:
undetectable
2aohA-1wcxA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
4 LEU A 310
ASP A 309
GLY A 330
ALA A 313
LEU  A 310 ( 0.6A)
ASP  A 309 ( 0.5A)
GLY  A 330 ( 0.0A)
ALA  A 313 ( 0.0A)
0.90A 2aohA-1wqaA:
undetectable
2aohA-1wqaA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)


(Thermus
thermophilus)
PF02347
(GDC-P)
4 LEU B 445
GLY B 398
PRO B 449
ALA B 448
None
0.85A 2aohA-1wytB:
undetectable
2aohA-1wytB:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN


(Streptococcus
pneumoniae)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
4 LEU A 215
GLY A 107
PRO A 218
ALA A 217
None
0.88A 2aohA-2am2A:
undetectable
2aohA-2am2A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwj PUTATIVE
ENDONUCLEASE


(Aeropyrum
pernix)
PF01042
(Ribonuc_L-PSP)
4 LEU A  49
GLY A  40
PRO A  28
ALA A  48
None
0.92A 2aohA-2cwjA:
undetectable
2aohA-2cwjA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE


(Equine
infectious
anemia virus)
PF00077
(RVP)
4 LEU A  23
ASP A  25
GLY A  55
PRO A  86
None
LP1  A 201 (-2.3A)
LP1  A 201 (-3.4A)
LP1  A 201 (-3.9A)
0.48A 2aohA-2fmbA:
15.0
2aohA-2fmbA:
33.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g17 N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE


(Salmonella
enterica)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
4 LEU A 310
ASP A 307
GLY A 188
ALA A 314
None
0.92A 2aohA-2g17A:
undetectable
2aohA-2g17A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES


(Bacillus
subtilis)
PF00082
(Peptidase_S8)
4 LEU A 288
ASP A 286
GLY A 215
ALA A 293
None
CA  A 612 (-3.1A)
None
None
0.97A 2aohA-2gkoA:
undetectable
2aohA-2gkoA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE


(Streptococcus
pneumoniae)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
4 LEU A 327
ASP A 324
GLY A 159
ALA A 331
None
None
NAP  A 367 ( 3.1A)
None
0.90A 2aohA-2gz3A:
undetectable
2aohA-2gz3A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE

(Chlamydomonas
reinhardtii)
PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
4 LEU A  91
ASP A  89
PRO A 154
ALA A  94
None
0.94A 2aohA-2n0sA:
undetectable
2aohA-2n0sA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus)
PF04960
(Glutaminase)
5 LEU A 290
ASP A 284
GLY A 261
PRO A 281
ALA A 282
None
1.36A 2aohA-2pbyA:
undetectable
2aohA-2pbyA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR


(Sinorhizobium
fredii)
PF00196
(GerE)
PF03472
(Autoind_bind)
4 LEU A  75
ASP A  72
GLY A 115
ALA A  78
None
LAE  A1001 (-3.0A)
None
None
0.70A 2aohA-2q0oA:
undetectable
2aohA-2q0oA:
17.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 LEU A  23
ASP A  25
GLY A  49
PRO A  81
ALA A  82
None
AB1  A 501 (-2.4A)
AB1  A 501 (-3.5A)
AB1  A 501 (-4.2A)
AB1  A 501 (-3.6A)
0.43A 2aohA-2rkfA:
20.8
2aohA-2rkfA:
83.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN


(Azospirillum
brasilense)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
4 LEU G 262
ASP G 263
GLY G 252
ALA G 245
None
0.97A 2aohA-2vdcG:
undetectable
2aohA-2vdcG:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG


(Escherichia
coli)
PF13377
(Peripla_BP_3)
4 LEU A  20
GLY A 270
PRO A 101
ALA A  78
None
0.80A 2aohA-3brqA:
undetectable
2aohA-3brqA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8n UROPORPHYRINOGEN-III
SYNTHASE


(Thermus
thermophilus)
PF02602
(HEM4)
4 LEU A 179
GLY A 214
PRO A 228
ALA A 210
None
0.87A 2aohA-3d8nA:
undetectable
2aohA-3d8nA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpr PROTEIN VP2
PROTEIN VP3


(Rhinovirus A)
PF00073
(Rhv)
4 LEU B 126
GLY C  38
PRO B 205
ALA B 204
None
0.97A 2aohA-3dprB:
undetectable
2aohA-3dprB:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE


(Trichoderma
reesei)
PF00026
(Asp)
4 LEU A 155
ASP A 304
GLY A  34
ALA A 153
None
0.88A 2aohA-3emyA:
6.6
2aohA-3emyA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8o KH DOMAIN-CONTAINING
PROTEIN MJ1533


(Methanocaldococcus
jannaschii)
PF01850
(PIN)
4 LEU A 132
ASP A  32
GLY A 115
ALA A 143
None
0.96A 2aohA-3i8oA:
undetectable
2aohA-3i8oA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE


(Burkholderia
pseudomallei)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
4 LEU A  29
ASP A  26
GLY A 247
ALA A  43
None
0.83A 2aohA-3imlA:
undetectable
2aohA-3imlA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A


(Archaeoglobus
fulgidus)
PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase)
4 ASP A 424
GLY A 277
PRO A 624
ALA A 625
None
0.78A 2aohA-3j09A:
undetectable
2aohA-3j09A:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE


(Thermus
thermophilus)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
4 LEU A 255
GLY A 403
PRO A 124
ALA A 123
None
0.83A 2aohA-3kfuA:
undetectable
2aohA-3kfuA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C


(Streptococcus
mutans)
PF08282
(Hydrolase_3)
4 ASP A   9
GLY A 182
PRO A 239
ALA A 238
MG  A 271 (-2.9A)
None
None
None
0.95A 2aohA-3l7yA:
undetectable
2aohA-3l7yA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1


(Saccharomyces
cerevisiae)
PF16499
(Melibiase_2)
4 LEU A 439
ASP A 436
GLY A 418
ALA A 310
None
None
None
GOL  A7003 (-3.6A)
0.89A 2aohA-3lrkA:
undetectable
2aohA-3lrkA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lye OXALOACETATE ACETYL
HYDROLASE


(Cryphonectria
parasitica)
PF13714
(PEP_mutase)
4 ASP A  95
GLY A  92
PRO A 314
ALA A 315
None
0.91A 2aohA-3lyeA:
undetectable
2aohA-3lyeA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus)
PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI)
4 LEU A 358
GLY A 136
PRO A 361
ALA A 360
None
0.97A 2aohA-3m6xA:
undetectable
2aohA-3m6xA:
12.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
None
0.28A 2aohA-3mwsA:
20.3
2aohA-3mwsA:
78.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa2 WBPB

(Pseudomonas
aeruginosa)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 ASP A  33
GLY A  39
PRO A  15
ALA A  14
NAD  A 317 (-2.7A)
None
None
None
0.95A 2aohA-3oa2A:
undetectable
2aohA-3oa2A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooq AMIDOHYDROLASE

(Thermotoga
maritima)
PF01979
(Amidohydro_1)
4 ASP A 232
GLY A 174
PRO A 124
ALA A 153
None
0.97A 2aohA-3ooqA:
undetectable
2aohA-3ooqA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnz PHOSPHOTRIESTERASE
FAMILY PROTEIN


(Listeria
monocytogenes)
PF02126
(PTE)
4 LEU A  40
ASP A  39
GLY A 285
ALA A 274
None
None
None
PO4  A 336 ( 4.3A)
0.88A 2aohA-3pnzA:
undetectable
2aohA-3pnzA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Vibrio cholerae)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
4 LEU A 352
ASP A 349
GLY A 165
ALA A 356
None
None
CYS  A 371 (-3.4A)
None
0.95A 2aohA-3pzrA:
undetectable
2aohA-3pzrA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR


(Arabidopsis
thaliana)
PF05147
(LANC_like)
4 LEU A 149
ASP A 146
GLY A 140
ALA A 133
None
0.96A 2aohA-3t33A:
undetectable
2aohA-3t33A:
15.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 LEU A  23
ASP A  25
GLY A  49
PRO A  81
ALA A  82
SO4  A 101 (-4.2A)
017  A 201 (-2.6A)
017  A 201 (-4.0A)
None
SO4  A 101 (-3.5A)
0.55A 2aohA-3t3cA:
18.8
2aohA-3t3cA:
75.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
None
017  A 201 (-2.6A)
017  A 201 (-3.0A)
017  A 201 (-4.1A)
0.40A 2aohA-3ttpA:
19.8
2aohA-3ttpA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL


(Homo sapiens)
PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase)
4 LEU A 513
ASP A 542
GLY A 522
PRO A 567
None
0.88A 2aohA-3u1kA:
undetectable
2aohA-3u1kA:
10.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u7s POL POLYPROTEIN

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
None
017  A 202 ( 2.5A)
017  A 202 (-2.9A)
017  A 202 (-4.0A)
0.40A 2aohA-3u7sA:
20.2
2aohA-3u7sA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Burkholderia
thailandensis)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
4 LEU A 356
ASP A 353
GLY A 165
ALA A 360
None
0.93A 2aohA-3uw3A:
undetectable
2aohA-3uw3A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE


(Thermococcus
kodakarensis)
PF00586
(AIRS)
PF02769
(AIRS_C)
4 LEU A 231
GLY A 174
PRO A 222
ALA A 230
None
0.96A 2aohA-3wjpA:
undetectable
2aohA-3wjpA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
4 LEU A 371
ASP A 604
GLY A 292
ALA A 347
None
0.94A 2aohA-4bziA:
undetectable
2aohA-4bziA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL


(Homo sapiens)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
4 ASP A 180
GLY A 243
PRO A 325
ALA A 324
None
0.91A 2aohA-4c2kA:
undetectable
2aohA-4c2kA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
4 LEU A 156
GLY A 243
PRO A  85
ALA A  86
None
SEP  A 104 ( 4.6A)
None
None
0.69A 2aohA-4hjhA:
undetectable
2aohA-4hjhA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix1 HYPOTHETICAL PROTEIN

(Rhodococcus
opacus)
no annotation 4 LEU A  30
GLY A 244
PRO A  35
ALA A  34
None
0.96A 2aohA-4ix1A:
undetectable
2aohA-4ix1A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkw BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1


(Homo sapiens)
PF07686
(V-set)
4 LEU A  73
ASP A  75
PRO A  24
ALA A  83
None
0.92A 2aohA-4jkwA:
undetectable
2aohA-4jkwA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ljp E3 UBIQUITIN-PROTEIN
LIGASE RNF31


(Homo sapiens)
no annotation 4 LEU A1057
GLY A1064
PRO A1017
ALA A1018
None
0.80A 2aohA-4ljpA:
undetectable
2aohA-4ljpA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs ACETALDEHYDE
DEHYDROGENASE


(Thermomonospora
curvata)
PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer)
4 LEU B 101
GLY B 181
PRO B 119
ALA B 120
None
PEG  B 409 ( 3.5A)
NAD  B 401 (-4.8A)
None
0.93A 2aohA-4lrsB:
undetectable
2aohA-4lrsB:
14.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
None
RIT  A 500 (-2.4A)
RIT  A 500 (-3.4A)
RIT  A 500 (-3.9A)
0.53A 2aohA-4njvA:
21.1
2aohA-4njvA:
84.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1i TRANSCRIPTIONAL
REGULATORY PROTEIN


(Mycobacterium
tuberculosis)
no annotation 4 LEU A   4
GLY A 113
PRO A  72
ALA A  45
None
0.96A 2aohA-4o1iA:
undetectable
2aohA-4o1iA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3


(Thermobaculum
terrenum)
PF00271
(Helicase_C)
4 LEU A 660
ASP A 626
GLY A 938
ALA A 662
None
0.93A 2aohA-4q2cA:
undetectable
2aohA-4q2cA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE


(Sphaerobacter
thermophilus)
PF01546
(Peptidase_M20)
4 ASP A 328
GLY A 154
PRO A  99
ALA A  96
SO4  A 401 ( 4.6A)
None
None
None
0.93A 2aohA-4q7aA:
undetectable
2aohA-4q7aA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167)
PF00232
(Glyco_hydro_1)
4 LEU A  46
ASP A  42
GLY A 138
ALA A 201
None
0.96A 2aohA-4r27A:
undetectable
2aohA-4r27A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE


(Mycobacterium
tuberculosis)
PF00202
(Aminotran_3)
4 LEU A  46
ASP A  59
GLY A 288
ALA A  41
None
0.85A 2aohA-4w1wA:
undetectable
2aohA-4w1wA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF


(Escherichia
coli)
PF04069
(OpuAC)
4 ASP A 272
GLY A 220
PRO A 245
ALA A 124
None
0.95A 2aohA-4wepA:
undetectable
2aohA-4wepA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE


(Francisella
tularensis)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
4 LEU A 348
ASP A 345
GLY A 166
ALA A 352
None
0.88A 2aohA-4wojA:
undetectable
2aohA-4wojA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY


(Bradyrhizobium
sp. BTAi1)
PF13407
(Peripla_BP_4)
4 LEU A  60
GLY A 315
PRO A 142
ALA A 118
None
0.89A 2aohA-4yhsA:
undetectable
2aohA-4yhsA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn2 FUSOLIN

(unidentified
entomopoxvirus)
PF03067
(LPMO_10)
4 LEU A  45
ASP A  42
GLY A  25
ALA A  54
None
0.94A 2aohA-4yn2A:
undetectable
2aohA-4yn2A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Pseudomonas
aeruginosa)
no annotation 4 LEU C 353
ASP C 350
GLY C 166
ALA C 357
None
0.97A 2aohA-5bntC:
undetectable
2aohA-5bntC:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN


(Thauera
aromatica)
PF01228
(Gly_radical)
PF02901
(PFL-like)
4 ASP A 733
GLY A 706
PRO A 517
ALA A 518
None
0.75A 2aohA-5bwdA:
undetectable
2aohA-5bwdA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79


(Burkholderia
pseudomallei)
PF12891
(Glyco_hydro_44)
4 LEU A 275
GLY A 266
PRO A 319
ALA A 274
None
0.90A 2aohA-5bwiA:
undetectable
2aohA-5bwiA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120)
PF04261
(Dyp_perox)
4 LEU A 255
GLY A 103
PRO A 460
ALA A 459
None
0.96A 2aohA-5c2iA:
undetectable
2aohA-5c2iA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN


(Thermobaculum
terrenum)
PF13181
(TPR_8)
PF13844
(Glyco_transf_41)
4 LEU A 354
GLY A 474
PRO A 331
ALA A 360
None
0.89A 2aohA-5djsA:
undetectable
2aohA-5djsA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE


(Thiobacillus
denitrificans)
PF13847
(Methyltransf_31)
4 LEU A 186
GLY A 111
PRO A  19
ALA A 187
None
SAH  A 301 (-4.9A)
None
None
0.96A 2aohA-5epeA:
undetectable
2aohA-5epeA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g10 HDAH

(Pseudomonas
aeruginosa)
PF00850
(Hist_deacetyl)
4 LEU A  75
ASP A  72
PRO A  69
ALA A  70
None
0.98A 2aohA-5g10A:
undetectable
2aohA-5g10A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
4 LEU A 161
ASP A 307
GLY A  37
ALA A 159
None
None
61P  A 406 ( 4.0A)
None
0.89A 2aohA-5hctA:
7.3
2aohA-5hctA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im5 DESIGNED
KETO-HYDROXYGLUTARAT
E-ALDOLASE/KETO-DEOX
Y-PHOSPHOGLUCONATE
ALDOLASE


(Vibrionales
bacterium
SWAT-3)
no annotation 4 LEU P  56
GLY P  36
PRO P  15
ALA P  40
None
0.96A 2aohA-5im5P:
undetectable
2aohA-5im5P:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf4 COLLAGEN ALPHA-1(XX)
CHAIN


(Homo sapiens)
PF00041
(fn3)
4 LEU A 377
GLY A 426
PRO A 380
ALA A 379
None
0.92A 2aohA-5kf4A:
undetectable
2aohA-5kf4A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE


(Thermococcus
kodakarensis)
no annotation 4 LEU A  66
GLY A 103
PRO A 177
ALA A 178
None
0.90A 2aohA-5nofA:
undetectable
2aohA-5nofA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E


(Legionella
pneumophila)
no annotation 4 ASP A 203
GLY A 200
PRO A 175
ALA A 176
None
SAM  A 501 (-2.9A)
SAM  A 501 (-3.4A)
None
0.78A 2aohA-5o96A:
undetectable
2aohA-5o96A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
4 LEU A 161
ASP A 307
GLY A  37
ALA A 159
None
0.88A 2aohA-5p60A:
7.3
2aohA-5p60A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae)
no annotation 4 LEU B 212
GLY B  34
PRO B 125
ALA B 130
None
0.91A 2aohA-5swiB:
undetectable
2aohA-5swiB:
9.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t2z PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
None
0.51A 2aohA-5t2zA:
20.2
2aohA-5t2zA:
80.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE


(Neisseria
gonorrhoeae)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
4 LEU A  28
ASP A  25
GLY A 248
ALA A  42
None
0.84A 2aohA-5t8tA:
undetectable
2aohA-5t8tA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti8 AMINOTRANSFERASE

(Pseudomonas sp.
M1)
PF00202
(Aminotran_3)
4 LEU A  46
ASP A  56
GLY A 295
ALA A  41
None
0.95A 2aohA-5ti8A:
undetectable
2aohA-5ti8A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE


(Pseudomonas sp.
AAC)
PF00171
(Aldedh)
4 LEU A 101
GLY A  91
PRO A 151
ALA A 152
None
0.88A 2aohA-5tjrA:
undetectable
2aohA-5tjrA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE


(Pseudomonas
aeruginosa)
PF03331
(LpxC)
4 LEU A 240
ASP A 241
GLY A 192
ALA A 188
None
ZN  A 501 ( 2.0A)
C90  A 502 ( 4.5A)
None
0.90A 2aohA-5u39A:
undetectable
2aohA-5u39A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE


(environmental
samples)
PF00202
(Aminotran_3)
4 LEU A  37
ASP A  47
GLY A 279
ALA A  32
None
None
LLP  A 274 ( 4.1A)
None
0.94A 2aohA-5uc7A:
undetectable
2aohA-5uc7A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE


(Streptomyces
peucetius)
no annotation 4 LEU A 298
ASP A 302
GLY A 268
ALA A 166
None
0.97A 2aohA-5wgcA:
undetectable
2aohA-5wgcA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqn PROBABLE
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00106
(adh_short)
4 ASP A  58
GLY A   8
PRO A 113
ALA A 112
None
0.92A 2aohA-5wqnA:
undetectable
2aohA-5wqnA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A


(Oryzias latipes)
PF01094
(ANF_receptor)
4 LEU A 431
ASP A 289
GLY A 217
ALA A 191
None
0.88A 2aohA-5x2qA:
undetectable
2aohA-5x2qA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER


(Klebsiella
pneumoniae)
PF03390
(2HCT)
4 LEU A 375
GLY A 234
PRO A 388
ALA A 378
None
0.80A 2aohA-5x9rA:
undetectable
2aohA-5x9rA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoy [LYSW]-LYSINE
HYDROLASE


(Thermus
thermophilus)
PF01546
(Peptidase_M20)
4 ASP A 325
GLY A 151
PRO A  95
ALA A  92
None
0.91A 2aohA-5xoyA:
undetectable
2aohA-5xoyA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S21
40S RIBOSOMAL
PROTEIN SA


(Trichomonas
vaginalis)
PF00318
(Ribosomal_S2)
PF01249
(Ribosomal_S21e)
4 LEU V  68
ASP A 156
GLY V  56
ALA V  67
None
0.70A 2aohA-5xyiV:
undetectable
2aohA-5xyiV:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ


(Aspergillus
nidulans)
no annotation 4 LEU B 204
GLY B 177
PRO B  12
ALA B  33
None
0.96A 2aohA-5y7rB:
undetectable
2aohA-5y7rB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Neisseria
gonorrhoeae)
no annotation 4 LEU A 353
ASP A 350
GLY A 166
ALA A 357
None
0.95A 2aohA-6bacA:
undetectable
2aohA-6bacA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4


(Mus musculus)
no annotation 4 LEU B 395
ASP B 396
GLY B 387
ALA B 391
None
0.90A 2aohA-6bcqB:
undetectable
2aohA-6bcqB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egt GLYCOPROTEIN

(Rift Valley
fever
phlebovirus)
no annotation 4 LEU A1034
ASP A1081
GLY A1078
ALA A1032
NAG  A1302 ( 4.4A)
NAG  A1302 (-3.5A)
FUL  A1304 ( 4.2A)
None
0.97A 2aohA-6egtA:
undetectable
2aohA-6egtA:
12.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6upj HIV-2 PROTEASE

(Human
immunodeficiency
virus 2)
PF00077
(RVP)
4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
None
NIU  A 100 (-2.8A)
NIU  A 100 ( 3.8A)
None
0.58A 2aohA-6upjA:
18.2
2aohA-6upjA:
49.49