SIMILAR PATTERNS OF AMINO ACIDS FOR 2AOH_C_FRDC305

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7b CELLOBIOSE
DEHYDROGENASE

(Phanerochaete
chrysosporium) 		PF16010
(CDH-cyt) 		4 ASP A  68
GLY A  58
PRO A  93
ALA A  87
 None
HEM  A 401 (-3.5A)
HEM  A 401 (-4.5A)
None
 0.68A 2aohA-1d7bA:
undetectable		 2aohA-1d7bA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		4 LEU A 108
GLY A  33
PRO A  68
ALA A  67
 None
 0.95A 2aohA-1fpsA:
undetectable		 2aohA-1fpsA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hrd GLUTAMATE
DEHYDROGENASE

([Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A 166
GLY A 134
PRO A  96
ALA A  95
 None
 0.95A 2aohA-1hrdA:
undetectable		 2aohA-1hrdA:
14.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
 A79  A 800 ( 4.0A)
A79  A 800 (-2.8A)
A79  A 800 (-3.4A)
A79  A 800 ( 3.4A)
 0.40A 2aohA-1hvcA:
13.9		 2aohA-1hvcA:
46.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knx PROBABLE HPR(SER)
KINASE/PHOSPHATASE

(Mycoplasma
pneumoniae) 		PF02603
(Hpr_kinase_N)
PF07475
(Hpr_kinase_C) 		4 LEU A 111
GLY A  34
PRO A  85
ALA A  86
 None
 0.89A 2aohA-1knxA:
undetectable		 2aohA-1knxA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		4 ASP A 102
GLY A 199
PRO A 202
ALA A 203
 None
 0.97A 2aohA-1ktnA:
undetectable		 2aohA-1ktnA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 LEU A 652
GLY A 582
PRO A 324
ALA A 649
 None
 0.71A 2aohA-1lf9A:
undetectable		 2aohA-1lf9A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 LEU A  37
ASP A  47
GLY A 279
ALA A  32
 None
 0.92A 2aohA-1mlzA:
undetectable		 2aohA-1mlzA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkv HYPOTHETICAL PROTEIN
YJHP

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		4 LEU A 186
GLY A 111
PRO A  19
ALA A 187
 None
 0.97A 2aohA-1nkvA:
undetectable		 2aohA-1nkvA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 LEU A 124
GLY A 151
PRO A 133
ALA A 132
 None
 0.97A 2aohA-1po0A:
undetectable		 2aohA-1po0A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqe VESICULAR TRANSPORT
PROTEIN SEC17

(Saccharomyces
cerevisiae) 		PF14938
(SNAP) 		4 LEU A  61
ASP A  58
GLY A  90
ALA A  83
 None
 0.86A 2aohA-1qqeA:
undetectable		 2aohA-1qqeA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
 None
 0.60A 2aohA-1sivA:
18.6		 2aohA-1sivA:
51.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te5 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF13230
(GATase_4) 		4 LEU A  54
ASP A  35
GLY A  28
PRO A  32
 None
 0.93A 2aohA-1te5A:
undetectable		 2aohA-1te5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		4 LEU A 653
GLY A 574
PRO A 312
ALA A 650
 None
 0.77A 2aohA-1ulvA:
undetectable		 2aohA-1ulvA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		4 LEU A 187
GLY A 222
PRO A 236
ALA A 218
 None
 0.93A 2aohA-1wcxA:
undetectable		 2aohA-1wcxA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A 310
ASP A 309
GLY A 330
ALA A 313
 LEU  A 310 ( 0.6A)
ASP  A 309 ( 0.5A)
GLY  A 330 ( 0.0A)
ALA  A 313 ( 0.0A)
 0.90A 2aohA-1wqaA:
undetectable		 2aohA-1wqaA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 LEU B 445
GLY B 398
PRO B 449
ALA B 448
 None
 0.85A 2aohA-1wytB:
undetectable		 2aohA-1wytB:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN

(Streptococcus
pneumoniae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 215
GLY A 107
PRO A 218
ALA A 217
 None
 0.88A 2aohA-2am2A:
undetectable		 2aohA-2am2A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwj PUTATIVE
ENDONUCLEASE

(Aeropyrum
pernix) 		PF01042
(Ribonuc_L-PSP) 		4 LEU A  49
GLY A  40
PRO A  28
ALA A  48
 None
 0.92A 2aohA-2cwjA:
undetectable		 2aohA-2cwjA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  55
PRO A  86
 None
LP1  A 201 (-2.3A)
LP1  A 201 (-3.4A)
LP1  A 201 (-3.9A)
 0.48A 2aohA-2fmbA:
15.0		 2aohA-2fmbA:
33.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g17 N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Salmonella
enterica) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A 310
ASP A 307
GLY A 188
ALA A 314
 None
 0.92A 2aohA-2g17A:
undetectable		 2aohA-2g17A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 LEU A 288
ASP A 286
GLY A 215
ALA A 293
 None
CA  A 612 (-3.1A)
None
None
 0.97A 2aohA-2gkoA:
undetectable		 2aohA-2gkoA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A 327
ASP A 324
GLY A 159
ALA A 331
 None
None
NAP  A 367 ( 3.1A)
None
 0.90A 2aohA-2gz3A:
undetectable		 2aohA-2gz3A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		4 LEU A  91
ASP A  89
PRO A 154
ALA A  94
 None
 0.94A 2aohA-2n0sA:
undetectable		 2aohA-2n0sA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus) 		PF04960
(Glutaminase) 		5 LEU A 290
ASP A 284
GLY A 261
PRO A 281
ALA A 282
 None
 1.36A 2aohA-2pbyA:
undetectable		 2aohA-2pbyA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR

(Sinorhizobium
fredii) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		4 LEU A  75
ASP A  72
GLY A 115
ALA A  78
 None
LAE  A1001 (-3.0A)
None
None
 0.70A 2aohA-2q0oA:
undetectable		 2aohA-2q0oA:
17.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 LEU A  23
ASP A  25
GLY A  49
PRO A  81
ALA A  82
 None
AB1  A 501 (-2.4A)
AB1  A 501 (-3.5A)
AB1  A 501 (-4.2A)
AB1  A 501 (-3.6A)
 0.43A 2aohA-2rkfA:
20.8		 2aohA-2rkfA:
83.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		4 LEU G 262
ASP G 263
GLY G 252
ALA G 245
 None
 0.97A 2aohA-2vdcG:
undetectable		 2aohA-2vdcG:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 LEU A  20
GLY A 270
PRO A 101
ALA A  78
 None
 0.80A 2aohA-3brqA:
undetectable		 2aohA-3brqA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8n UROPORPHYRINOGEN-III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		4 LEU A 179
GLY A 214
PRO A 228
ALA A 210
 None
 0.87A 2aohA-3d8nA:
undetectable		 2aohA-3d8nA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpr PROTEIN VP2
PROTEIN VP3

(Rhinovirus A) 		PF00073
(Rhv) 		4 LEU B 126
GLY C  38
PRO B 205
ALA B 204
 None
 0.97A 2aohA-3dprB:
undetectable		 2aohA-3dprB:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		4 LEU A 155
ASP A 304
GLY A  34
ALA A 153
 None
 0.88A 2aohA-3emyA:
6.6		 2aohA-3emyA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8o KH DOMAIN-CONTAINING
PROTEIN MJ1533

(Methanocaldococcus
jannaschii) 		PF01850
(PIN) 		4 LEU A 132
ASP A  32
GLY A 115
ALA A 143
 None
 0.96A 2aohA-3i8oA:
undetectable		 2aohA-3i8oA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iml S-ADENOSYLMETHIONINE
SYNTHETASE

(Burkholderia
pseudomallei) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 LEU A  29
ASP A  26
GLY A 247
ALA A  43
 None
 0.83A 2aohA-3imlA:
undetectable		 2aohA-3imlA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase) 		4 ASP A 424
GLY A 277
PRO A 624
ALA A 625
 None
 0.78A 2aohA-3j09A:
undetectable		 2aohA-3j09A:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 255
GLY A 403
PRO A 124
ALA A 123
 None
 0.83A 2aohA-3kfuA:
undetectable		 2aohA-3kfuA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C

(Streptococcus
mutans) 		PF08282
(Hydrolase_3) 		4 ASP A   9
GLY A 182
PRO A 239
ALA A 238
 MG  A 271 (-2.9A)
None
None
None
 0.95A 2aohA-3l7yA:
undetectable		 2aohA-3l7yA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1

(Saccharomyces
cerevisiae) 		PF16499
(Melibiase_2) 		4 LEU A 439
ASP A 436
GLY A 418
ALA A 310
 None
None
None
GOL  A7003 (-3.6A)
 0.89A 2aohA-3lrkA:
undetectable		 2aohA-3lrkA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lye OXALOACETATE ACETYL
HYDROLASE

(Cryphonectria
parasitica) 		PF13714
(PEP_mutase) 		4 ASP A  95
GLY A  92
PRO A 314
ALA A 315
 None
 0.91A 2aohA-3lyeA:
undetectable		 2aohA-3lyeA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		4 LEU A 358
GLY A 136
PRO A 361
ALA A 360
 None
 0.97A 2aohA-3m6xA:
undetectable		 2aohA-3m6xA:
12.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
 None
 0.28A 2aohA-3mwsA:
20.3		 2aohA-3mwsA:
78.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa2 WBPB

(Pseudomonas
aeruginosa) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ASP A  33
GLY A  39
PRO A  15
ALA A  14
 NAD  A 317 (-2.7A)
None
None
None
 0.95A 2aohA-3oa2A:
undetectable		 2aohA-3oa2A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooq AMIDOHYDROLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		4 ASP A 232
GLY A 174
PRO A 124
ALA A 153
 None
 0.97A 2aohA-3ooqA:
undetectable		 2aohA-3ooqA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnz PHOSPHOTRIESTERASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF02126
(PTE) 		4 LEU A  40
ASP A  39
GLY A 285
ALA A 274
 None
None
None
PO4  A 336 ( 4.3A)
 0.88A 2aohA-3pnzA:
undetectable		 2aohA-3pnzA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A 352
ASP A 349
GLY A 165
ALA A 356
 None
None
CYS  A 371 (-3.4A)
None
 0.95A 2aohA-3pzrA:
undetectable		 2aohA-3pzrA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR

(Arabidopsis
thaliana) 		PF05147
(LANC_like) 		4 LEU A 149
ASP A 146
GLY A 140
ALA A 133
 None
 0.96A 2aohA-3t33A:
undetectable		 2aohA-3t33A:
15.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 LEU A  23
ASP A  25
GLY A  49
PRO A  81
ALA A  82
 SO4  A 101 (-4.2A)
017  A 201 (-2.6A)
017  A 201 (-4.0A)
None
SO4  A 101 (-3.5A)
 0.55A 2aohA-3t3cA:
18.8		 2aohA-3t3cA:
75.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
 None
017  A 201 (-2.6A)
017  A 201 (-3.0A)
017  A 201 (-4.1A)
 0.40A 2aohA-3ttpA:
19.8		 2aohA-3ttpA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 LEU A 513
ASP A 542
GLY A 522
PRO A 567
 None
 0.88A 2aohA-3u1kA:
undetectable		 2aohA-3u1kA:
10.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u7s POL POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
 None
017  A 202 ( 2.5A)
017  A 202 (-2.9A)
017  A 202 (-4.0A)
 0.40A 2aohA-3u7sA:
20.2		 2aohA-3u7sA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Burkholderia
thailandensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A 356
ASP A 353
GLY A 165
ALA A 360
 None
 0.93A 2aohA-3uw3A:
undetectable		 2aohA-3uw3A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Thermococcus
kodakarensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 231
GLY A 174
PRO A 222
ALA A 230
 None
 0.96A 2aohA-3wjpA:
undetectable		 2aohA-3wjpA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 LEU A 371
ASP A 604
GLY A 292
ALA A 347
 None
 0.94A 2aohA-4bziA:
undetectable		 2aohA-4bziA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ASP A 180
GLY A 243
PRO A 325
ALA A 324
 None
 0.91A 2aohA-4c2kA:
undetectable		 2aohA-4c2kA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A 156
GLY A 243
PRO A  85
ALA A  86
 None
SEP  A 104 ( 4.6A)
None
None
 0.69A 2aohA-4hjhA:
undetectable		 2aohA-4hjhA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix1 HYPOTHETICAL PROTEIN

(Rhodococcus
opacus) 		no annotation 4 LEU A  30
GLY A 244
PRO A  35
ALA A  34
 None
 0.96A 2aohA-4ix1A:
undetectable		 2aohA-4ix1A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkw BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1

(Homo sapiens) 		PF07686
(V-set) 		4 LEU A  73
ASP A  75
PRO A  24
ALA A  83
 None
 0.92A 2aohA-4jkwA:
undetectable		 2aohA-4jkwA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ljp E3 UBIQUITIN-PROTEIN
LIGASE RNF31

(Homo sapiens) 		no annotation 4 LEU A1057
GLY A1064
PRO A1017
ALA A1018
 None
 0.80A 2aohA-4ljpA:
undetectable		 2aohA-4ljpA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs ACETALDEHYDE
DEHYDROGENASE

(Thermomonospora
curvata) 		PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		4 LEU B 101
GLY B 181
PRO B 119
ALA B 120
 None
PEG  B 409 ( 3.5A)
NAD  B 401 (-4.8A)
None
 0.93A 2aohA-4lrsB:
undetectable		 2aohA-4lrsB:
14.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
 None
RIT  A 500 (-2.4A)
RIT  A 500 (-3.4A)
RIT  A 500 (-3.9A)
 0.53A 2aohA-4njvA:
21.1		 2aohA-4njvA:
84.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1i TRANSCRIPTIONAL
REGULATORY PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A   4
GLY A 113
PRO A  72
ALA A  45
 None
 0.96A 2aohA-4o1iA:
undetectable		 2aohA-4o1iA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		4 LEU A 660
ASP A 626
GLY A 938
ALA A 662
 None
 0.93A 2aohA-4q2cA:
undetectable		 2aohA-4q2cA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus) 		PF01546
(Peptidase_M20) 		4 ASP A 328
GLY A 154
PRO A  99
ALA A  96
 SO4  A 401 ( 4.6A)
None
None
None
 0.93A 2aohA-4q7aA:
undetectable		 2aohA-4q7aA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		4 LEU A  46
ASP A  42
GLY A 138
ALA A 201
 None
 0.96A 2aohA-4r27A:
undetectable		 2aohA-4r27A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		4 LEU A  46
ASP A  59
GLY A 288
ALA A  41
 None
 0.85A 2aohA-4w1wA:
undetectable		 2aohA-4w1wA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wep PUTATIVE
OSMOPROTECTANT
UPTAKE SYSTEM
SUBSTRATE-BINDING
PROTEIN OSMF

(Escherichia
coli) 		PF04069
(OpuAC) 		4 ASP A 272
GLY A 220
PRO A 245
ALA A 124
 None
 0.95A 2aohA-4wepA:
undetectable		 2aohA-4wepA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Francisella
tularensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A 348
ASP A 345
GLY A 166
ALA A 352
 None
 0.88A 2aohA-4wojA:
undetectable		 2aohA-4wojA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp. BTAi1) 		PF13407
(Peripla_BP_4) 		4 LEU A  60
GLY A 315
PRO A 142
ALA A 118
 None
 0.89A 2aohA-4yhsA:
undetectable		 2aohA-4yhsA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn2 FUSOLIN

(unidentified
entomopoxvirus) 		PF03067
(LPMO_10) 		4 LEU A  45
ASP A  42
GLY A  25
ALA A  54
 None
 0.94A 2aohA-4yn2A:
undetectable		 2aohA-4yn2A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		no annotation 4 LEU C 353
ASP C 350
GLY C 166
ALA C 357
 None
 0.97A 2aohA-5bntC:
undetectable		 2aohA-5bntC:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN

(Thauera
aromatica) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ASP A 733
GLY A 706
PRO A 517
ALA A 518
 None
 0.75A 2aohA-5bwdA:
undetectable		 2aohA-5bwdA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79

(Burkholderia
pseudomallei) 		PF12891
(Glyco_hydro_44) 		4 LEU A 275
GLY A 266
PRO A 319
ALA A 274
 None
 0.90A 2aohA-5bwiA:
undetectable		 2aohA-5bwiA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120) 		PF04261
(Dyp_perox) 		4 LEU A 255
GLY A 103
PRO A 460
ALA A 459
 None
 0.96A 2aohA-5c2iA:
undetectable		 2aohA-5c2iA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN

(Thermobaculum
terrenum) 		PF13181
(TPR_8)
PF13844
(Glyco_transf_41) 		4 LEU A 354
GLY A 474
PRO A 331
ALA A 360
 None
 0.89A 2aohA-5djsA:
undetectable		 2aohA-5djsA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE

(Thiobacillus
denitrificans) 		PF13847
(Methyltransf_31) 		4 LEU A 186
GLY A 111
PRO A  19
ALA A 187
 None
SAH  A 301 (-4.9A)
None
None
 0.96A 2aohA-5epeA:
undetectable		 2aohA-5epeA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g10 HDAH

(Pseudomonas
aeruginosa) 		PF00850
(Hist_deacetyl) 		4 LEU A  75
ASP A  72
PRO A  69
ALA A  70
 None
 0.98A 2aohA-5g10A:
undetectable		 2aohA-5g10A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 LEU A 161
ASP A 307
GLY A  37
ALA A 159
 None
None
61P  A 406 ( 4.0A)
None
 0.89A 2aohA-5hctA:
7.3		 2aohA-5hctA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im5 DESIGNED
KETO-HYDROXYGLUTARAT
E-ALDOLASE/KETO-DEOX
Y-PHOSPHOGLUCONATE
ALDOLASE

(Vibrionales
bacterium
SWAT-3) 		no annotation 4 LEU P  56
GLY P  36
PRO P  15
ALA P  40
 None
 0.96A 2aohA-5im5P:
undetectable		 2aohA-5im5P:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf4 COLLAGEN ALPHA-1(XX)
CHAIN

(Homo sapiens) 		PF00041
(fn3) 		4 LEU A 377
GLY A 426
PRO A 380
ALA A 379
 None
 0.92A 2aohA-5kf4A:
undetectable		 2aohA-5kf4A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermococcus
kodakarensis) 		no annotation 4 LEU A  66
GLY A 103
PRO A 177
ALA A 178
 None
 0.90A 2aohA-5nofA:
undetectable		 2aohA-5nofA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila) 		no annotation 4 ASP A 203
GLY A 200
PRO A 175
ALA A 176
 None
SAM  A 501 (-2.9A)
SAM  A 501 (-3.4A)
None
 0.78A 2aohA-5o96A:
undetectable		 2aohA-5o96A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 LEU A 161
ASP A 307
GLY A  37
ALA A 159
 None
 0.88A 2aohA-5p60A:
7.3		 2aohA-5p60A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 4 LEU B 212
GLY B  34
PRO B 125
ALA B 130
 None
 0.91A 2aohA-5swiB:
undetectable		 2aohA-5swiB:
9.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t2z PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
 None
 0.51A 2aohA-5t2zA:
20.2		 2aohA-5t2zA:
80.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8t S-ADENOSYLMETHIONINE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 LEU A  28
ASP A  25
GLY A 248
ALA A  42
 None
 0.84A 2aohA-5t8tA:
undetectable		 2aohA-5t8tA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti8 AMINOTRANSFERASE

(Pseudomonas sp.
M1) 		PF00202
(Aminotran_3) 		4 LEU A  46
ASP A  56
GLY A 295
ALA A  41
 None
 0.95A 2aohA-5ti8A:
undetectable		 2aohA-5ti8A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
AAC) 		PF00171
(Aldedh) 		4 LEU A 101
GLY A  91
PRO A 151
ALA A 152
 None
 0.88A 2aohA-5tjrA:
undetectable		 2aohA-5tjrA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE

(Pseudomonas
aeruginosa) 		PF03331
(LpxC) 		4 LEU A 240
ASP A 241
GLY A 192
ALA A 188
 None
ZN  A 501 ( 2.0A)
C90  A 502 ( 4.5A)
None
 0.90A 2aohA-5u39A:
undetectable		 2aohA-5u39A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(environmental
samples) 		PF00202
(Aminotran_3) 		4 LEU A  37
ASP A  47
GLY A 279
ALA A  32
 None
None
LLP  A 274 ( 4.1A)
None
 0.94A 2aohA-5uc7A:
undetectable		 2aohA-5uc7A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 4 LEU A 298
ASP A 302
GLY A 268
ALA A 166
 None
 0.97A 2aohA-5wgcA:
undetectable		 2aohA-5wgcA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqn PROBABLE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		4 ASP A  58
GLY A   8
PRO A 113
ALA A 112
 None
 0.92A 2aohA-5wqnA:
undetectable		 2aohA-5wqnA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		4 LEU A 431
ASP A 289
GLY A 217
ALA A 191
 None
 0.88A 2aohA-5x2qA:
undetectable		 2aohA-5x2qA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER

(Klebsiella
pneumoniae) 		PF03390
(2HCT) 		4 LEU A 375
GLY A 234
PRO A 388
ALA A 378
 None
 0.80A 2aohA-5x9rA:
undetectable		 2aohA-5x9rA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoy [LYSW]-LYSINE
HYDROLASE

(Thermus
thermophilus) 		PF01546
(Peptidase_M20) 		4 ASP A 325
GLY A 151
PRO A  95
ALA A  92
 None
 0.91A 2aohA-5xoyA:
undetectable		 2aohA-5xoyA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S21
40S RIBOSOMAL
PROTEIN SA

(Trichomonas
vaginalis) 		PF00318
(Ribosomal_S2)
PF01249
(Ribosomal_S21e) 		4 LEU V  68
ASP A 156
GLY V  56
ALA V  67
 None
 0.70A 2aohA-5xyiV:
undetectable		 2aohA-5xyiV:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ

(Aspergillus
nidulans) 		no annotation 4 LEU B 204
GLY B 177
PRO B  12
ALA B  33
 None
 0.96A 2aohA-5y7rB:
undetectable		 2aohA-5y7rB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		no annotation 4 LEU A 353
ASP A 350
GLY A 166
ALA A 357
 None
 0.95A 2aohA-6bacA:
undetectable		 2aohA-6bacA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Mus musculus) 		no annotation 4 LEU B 395
ASP B 396
GLY B 387
ALA B 391
 None
 0.90A 2aohA-6bcqB:
undetectable		 2aohA-6bcqB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egt GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		no annotation 4 LEU A1034
ASP A1081
GLY A1078
ALA A1032
 NAG  A1302 ( 4.4A)
NAG  A1302 (-3.5A)
FUL  A1304 ( 4.2A)
None
 0.97A 2aohA-6egtA:
undetectable		 2aohA-6egtA:
12.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6upj HIV-2 PROTEASE

(Human
immunodeficiency
virus 2) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
PRO A  81
 None
NIU  A 100 (-2.8A)
NIU  A 100 ( 3.8A)
None
 0.58A 2aohA-6upjA:
18.2		 2aohA-6upjA:
49.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axn ANNEXIN III

(Homo sapiens) 		PF00191
(Annexin) 		4 ASP A 112
GLY A 235
ALA A 243
ILE A 115
 None
 0.73A 2aohB-1axnA:
undetectable		 2aohB-1axnA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdb CIS-BIPHENYL-2,3-DIH
YDRODIOL-2,3-DEHYDRO
GENASE

(Pseudomonas sp.) 		PF00106
(adh_short) 		4 LEU A 165
GLY A  88
ALA A 161
ILE A 162
 None
NAD  A 300 ( 3.9A)
None
None
 0.81A 2aohB-1bdbA:
undetectable		 2aohB-1bdbA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwz PROTEIN
(DIAMINOPIMELATE
EPIMERASE)

(Haemophilus
influenzae) 		PF01678
(DAP_epimerase) 		4 LEU A 247
GLY A 119
ALA A 221
ILE A 249
 None
 0.76A 2aohB-1bwzA:
0.0		 2aohB-1bwzA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 ASP A 207
GLY A 217
ALA A 242
ILE A 243
 None
 0.81A 2aohB-1d9zA:
0.0		 2aohB-1d9zA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpb DIHYDROLIPOYL-TRANSA
CETYLASE

(Azotobacter
vinelandii) 		PF00198
(2-oxoacid_dh) 		4 LEU A 629
GLY A 561
ALA A 441
ILE A 443
 None
 0.81A 2aohB-1dpbA:
undetectable		 2aohB-1dpbA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3b GLUTATHIONE
S-TRANSFERASE YA
CHAIN

(Mus musculus) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A  71
GLY A  26
ALA A  75
ILE A  74
 None
 0.80A 2aohB-1f3bA:
undetectable		 2aohB-1f3bA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 LEU A 112
GLY A  65
ALA A 108
ILE A 109
 None
 0.70A 2aohB-1h74A:
undetectable		 2aohB-1h74A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsj FUSION PROTEIN
CONSISTING OF
STAPHYLOCOCCUS
ACCESSORY REGULATOR
PROTEIN R AND
MALTOSE BINDING
PROTEIN

(Escherichia
coli;
Staphylococcus
aureus) 		PF01547
(SBP_bac_1) 		4 LEU A 262
GLY A 289
ALA A 109
ILE A 108
 None
 0.80A 2aohB-1hsjA:
undetectable		 2aohB-1hsjA:
12.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
ILE A  84
 A79  A 800 ( 3.8A)
A79  A 800 (-2.7A)
A79  A 800 ( 3.7A)
A79  A 800 (-3.6A)
 0.23A 2aohB-1hvcA:
13.9		 2aohB-1hvcA:
46.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
ILE A  84
 A79  A 800 ( 4.0A)
A79  A 800 (-2.8A)
A79  A 800 (-3.4A)
A79  A 800 (-3.8A)
 0.31A 2aohB-1hvcA:
13.9		 2aohB-1hvcA:
46.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 LEU A 111
GLY A 339
ALA A 114
ILE A 110
 None
 0.72A 2aohB-1hwwA:
undetectable		 2aohB-1hwwA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir6 EXONUCLEASE RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 LEU A 131
GLY A  95
ALA A  68
ILE A  75
 None
 0.82A 2aohB-1ir6A:
undetectable		 2aohB-1ir6A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kng THIOL:DISULFIDE
INTERCHANGE PROTEIN
CYCY

(Bradyrhizobium
japonicum) 		PF08534
(Redoxin) 		4 LEU A  57
ASP A 142
GLY A 152
ILE A 116
 None
 0.86A 2aohB-1kngA:
undetectable		 2aohB-1kngA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgf P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 LEU A 195
ASP A 223
GLY A 218
ALA A 199
ILE A 198
 None
 1.34A 2aohB-1lgfA:
undetectable		 2aohB-1lgfA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		4 LEU A 535
GLY A 402
ALA A 538
ILE A 534
 None
 0.73A 2aohB-1mt5A:
undetectable		 2aohB-1mt5A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0w RIBONUCLEASE III

(Thermotoga
maritima) 		PF00035
(dsrm)
PF14622
(Ribonucleas_3_3) 		4 LEU A 125
GLY A 110
ALA A 128
ILE A 124
 None
 0.85A 2aohB-1o0wA:
undetectable		 2aohB-1o0wA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odi PURINE NUCLEOSIDE
PHOSPHORYLASE

(Thermus
thermophilus) 		PF01048
(PNP_UDP_1) 		4 LEU A 200
GLY A 174
ALA A 106
ILE A 104
 None
 0.86A 2aohB-1odiA:
undetectable		 2aohB-1odiA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p74 SHIKIMATE
5-DEHYDROGENASE

(Haemophilus
influenzae) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 LEU A 147
GLY A 103
ALA A 127
ILE A 124
 None
 0.83A 2aohB-1p74A:
undetectable		 2aohB-1p74A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Drosophila
melanogaster;
Escherichia
coli) 		no annotation 4 LEU P 261
GLY P 288
ALA P 108
ILE P 107
 None
 0.84A 2aohB-1r6zP:
undetectable		 2aohB-1r6zP:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7g NAD-DEPENDENT
DEACETYLASE 2

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		4 LEU A  88
GLY A 191
ALA A  84
ILE A  85
 None
NAD  A 703 (-3.5A)
None
None
 0.84A 2aohB-1s7gA:
undetectable		 2aohB-1s7gA:
13.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
ILE A  84
 None
 0.38A 2aohB-1sivA:
18.6		 2aohB-1sivA:
51.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 LEU A 174
GLY A 101
ALA A 146
ILE A 148
 None
SO4  A 401 (-3.4A)
None
None
 0.84A 2aohB-1sxrA:
undetectable		 2aohB-1sxrA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tol PROTEIN (FUSION
PROTEIN CONSISTING
OF MINOR COAT
PROTEIN, GLYCINE
RICH LINKER, TOLA,
AND A HIS TAG)

(Escherichia
coli;
Escherichia
virus M13) 		PF05357
(Phage_Coat_A)
PF06519
(TolA) 		4 LEU A 209
GLY A 165
ALA A 207
ILE A 159
 None
 0.85A 2aohB-1tolA:
undetectable		 2aohB-1tolA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		4 LEU A 806
GLY A 954
ALA A 869
ILE A 867
 None
 0.78A 2aohB-1uf2A:
undetectable		 2aohB-1uf2A:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufb TT1696 PROTEIN

(Thermus
thermophilus) 		PF05168
(HEPN) 		5 LEU A  82
ASP A  83
GLY A  55
ALA A  38
ILE A  58
 None
 1.35A 2aohB-1ufbA:
undetectable		 2aohB-1ufbA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN

(Pyrococcus
horikoshii) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 LEU A   9
GLY A 299
ALA A  12
ILE A 279
 None
 0.83A 2aohB-1uz5A:
undetectable		 2aohB-1uz5A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf1 GLUTATHIONE
S-TRANSFERASE 3

(Gallus gallus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A  72
GLY A  27
ALA A  76
ILE A  75
 None
 0.82A 2aohB-1vf1A:
undetectable		 2aohB-1vf1A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w4t ARYLAMINE
N-ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00797
(Acetyltransf_2) 		4 LEU A  29
GLY A 130
ALA A 139
ILE A  33
 None
 0.78A 2aohB-1w4tA:
undetectable		 2aohB-1w4tA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wol 122AA LONG CONSERVED
HYPOTHETICAL PROTEIN

(Sulfurisphaera
tokodaii) 		PF05168
(HEPN) 		5 LEU A  76
ASP A  77
GLY A  55
ALA A  38
ILE A  58
 None
 1.43A 2aohB-1wolA:
undetectable		 2aohB-1wolA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfb ALDOLASE C

(Homo sapiens) 		PF00274
(Glycolytic) 		4 LEU A  16
GLY A 106
ALA A  20
ILE A  19
 None
 0.86A 2aohB-1xfbA:
undetectable		 2aohB-1xfbA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE

(Escherichia
coli) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 LEU A  31
GLY A  54
ALA A  37
ILE A  30
 None
 0.75A 2aohB-1xrcA:
undetectable		 2aohB-1xrcA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4c MALTOSE BINDING
PROTEIN FUSED WITH
DESIGNED HELICAL
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 LEU A 262
GLY A 289
ALA A 109
ILE A 108
 None
 0.84A 2aohB-1y4cA:
undetectable		 2aohB-1y4cA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		4 LEU A 216
ASP A 218
ALA A 303
ILE A 305
 None
A70  A 500 ( 2.3A)
A70  A 500 ( 3.8A)
A70  A 500 (-4.8A)
 0.80A 2aohB-1zapA:
7.0		 2aohB-1zapA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zem XYLITOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF13561
(adh_short_C2) 		4 LEU A 167
GLY A  93
ALA A 163
ILE A 164
 None
NAD  A2263 (-3.6A)
None
None
 0.77A 2aohB-1zemA:
undetectable		 2aohB-1zemA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkd DUF185

(Rhodopseudomonas
palustris) 		PF02636
(Methyltransf_28) 		4 LEU A 225
ASP A 221
ALA A 228
ILE A 224
 None
 0.70A 2aohB-1zkdA:
undetectable		 2aohB-1zkdA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A   9
GLY A 282
ALA A 138
ILE A 140
 FAD  A 480 (-4.1A)
None
None
None
 0.83A 2aohB-2a8xA:
undetectable		 2aohB-2a8xA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4n PROTEIN NAGD

(Escherichia
coli) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 LEU A  41
GLY A 214
ALA A 185
ILE A   7
 None
 0.78A 2aohB-2c4nA:
undetectable		 2aohB-2c4nA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c8j FERROCHELATASE 1

(Bacillus
anthracis) 		PF00762
(Ferrochelatase) 		4 LEU A   8
GLY A 136
ALA A 107
ILE A 140
 None
 0.86A 2aohB-2c8jA:
undetectable		 2aohB-2c8jA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE

(Thermus
thermophilus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A 252
GLY A 263
ALA A 272
ILE A 274
 None
 0.86A 2aohB-2cukA:
undetectable		 2aohB-2cukA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyu TWITCHING MOTILITY
PROTEIN PILT

(Aquifex
aeolicus) 		PF00437
(T2SSE) 		4 LEU A 305
GLY A 321
ALA A 301
ILE A 302
 None
 0.74A 2aohB-2eyuA:
undetectable		 2aohB-2eyuA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhe GLUTATHIONE
S-TRANSFERASE

(Fasciola
hepatica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A  71
GLY A  24
ALA A  75
ILE A  74
 None
 0.82A 2aohB-2fheA:
undetectable		 2aohB-2fheA:
18.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  55
ILE A  89
 None
LP1  A 201 (-2.3A)
LP1  A 201 (-3.4A)
LP1  A 201 (-4.2A)
 0.33A 2aohB-2fmbA:
15.0		 2aohB-2fmbA:
33.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5d GNA33

(Neisseria
gonorrhoeae) 		PF03562
(MltA)
PF06725
(3D) 		4 LEU A 372
GLY A 139
ALA A 391
ILE A 389
 None
 0.82A 2aohB-2g5dA:
undetectable		 2aohB-2g5dA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)

(West Nile virus) 		PF00972
(Flavi_NS5) 		4 LEU A 521
GLY A 511
ALA A 664
ILE A 520
 None
 0.85A 2aohB-2hcsA:
undetectable		 2aohB-2hcsA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 LEU A 152
ASP A 150
GLY A 135
ALA A 126
 URE  A 578 (-4.7A)
None
None
None
 0.82A 2aohB-2i1jA:
undetectable		 2aohB-2i1jA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iir ACETATE KINASE

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		4 LEU A  56
GLY A 129
ALA A  31
ILE A  34
 None
 0.85A 2aohB-2iirA:
undetectable		 2aohB-2iirA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jz1 PROTEIN DOUBLESEX

(Drosophila
melanogaster) 		PF08828
(DSX_dimer) 		4 LEU A  34
GLY A  51
ALA A  37
ILE A  33
 None
 0.84A 2aohB-2jz1A:
undetectable		 2aohB-2jz1A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otn DIAMINOPIMELATE
EPIMERASE

(Bacillus
anthracis) 		PF01678
(DAP_epimerase) 		4 LEU A 258
GLY A 126
ALA A 230
ILE A 260
 None
 0.67A 2aohB-2otnA:
undetectable		 2aohB-2otnA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 LEU A  19
GLY A  53
ALA A  22
ILE A  18
 None
 0.70A 2aohB-2p4qA:
undetectable		 2aohB-2p4qA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Pseudomonas
savastanoi) 		PF01966
(HD) 		4 LEU A 370
GLY A 153
ALA A 123
ILE A 124
 None
 0.84A 2aohB-2pgsA:
undetectable		 2aohB-2pgsA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR

(Sinorhizobium
fredii) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		4 LEU A  75
ASP A  72
GLY A 115
ALA A  78
 None
LAE  A1001 (-3.0A)
None
None
 0.66A 2aohB-2q0oA:
undetectable		 2aohB-2q0oA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		4 LEU A 216
ASP A 218
ALA A 303
ILE A 305
 None
 0.84A 2aohB-2qzwA:
7.7		 2aohB-2qzwA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2re7 UNCHARACTERIZED
PROTEIN

(Psychrobacter
arcticus) 		PF16242
(Pyrid_ox_like) 		4 LEU A  70
GLY A  52
ALA A  20
ILE A  22
 None
 0.75A 2aohB-2re7A:
undetectable		 2aohB-2re7A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		4 LEU A 156
GLY A 163
ALA A 146
ILE A 144
 None
 0.75A 2aohB-2rgjA:
undetectable		 2aohB-2rgjA:
16.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 LEU A  23
ASP A  25
GLY A  49
ALA A  82
ILE A  84
 None
AB1  A 501 (-2.4A)
AB1  A 501 (-3.5A)
AB1  A 501 (-3.6A)
AB1  A 501 ( 4.2A)
 0.43A 2aohB-2rkfA:
20.8		 2aohB-2rkfA:
83.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8n LACTOSE PERMEASE

(Escherichia
coli) 		PF01306
(LacY_symp) 		4 LEU A  76
GLY A 115
ALA A 124
ILE A  80
 None
 0.84A 2aohB-2v8nA:
undetectable		 2aohB-2v8nA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		4 LEU A 262
GLY A 289
ALA A 109
ILE A 108
 None
 0.86A 2aohB-2vgqA:
undetectable		 2aohB-2vgqA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 LEU A 494
GLY A 513
ALA A 465
ILE A 467
 None
 0.81A 2aohB-2wyhA:
undetectable		 2aohB-2wyhA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine leukemia
virus;
Escherichia
coli) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		4 LEU A 288
GLY A 315
ALA A 135
ILE A 134
 None
EDO  A1491 ( 3.7A)
None
None
 0.81A 2aohB-2xz3A:
undetectable		 2aohB-2xz3A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z55 ARCHAERHODOPSIN-2

(Halobacterium
sp. AUS-2) 		PF01036
(Bac_rhodopsin) 		4 LEU A 235
GLY A 225
ALA A  43
ILE A 234
 None
 0.83A 2aohB-2z55A:
undetectable		 2aohB-2z55A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 LEU A 131
GLY A  95
ALA A  68
ILE A  75
 None
 0.81A 2aohB-2zxoA:
undetectable		 2aohB-2zxoA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3c MALTOSE-BINDING
PERIPLASMIC PROTEIN,
LINKER,
MITOCHONDRIAL
INTERMEMBRANE SPACE
IMPORT AND ASSEMBLY
PROTEIN 40

(Escherichia
coli;
Saccharomyces
cerevisiae;
synthetic
construct) 		PF06747
(CHCH)
PF13416
(SBP_bac_8) 		4 LEU A 262
GLY A 289
ALA A 109
ILE A 108
 None
 0.77A 2aohB-3a3cA:
undetectable		 2aohB-3a3cA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8l UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		4 LEU A  14
GLY A  85
ALA A  10
ILE A  11
 None
 0.84A 2aohB-3b8lA:
undetectable		 2aohB-3b8lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgg SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		5 LEU A  63
ASP A  51
GLY A 145
ALA A  36
ILE A  59
 None
 1.48A 2aohB-3cggA:
undetectable		 2aohB-3cggA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 LEU A 521
ASP A 525
ALA A 516
ILE A 517
 None
 0.82A 2aohB-3cghA:
undetectable		 2aohB-3cghA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Arabidopsis
thaliana;
Escherichia
coli) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		4 LEU A 262
GLY A 289
ALA A 109
ILE A 108
 None
 0.86A 2aohB-3dm0A:
undetectable		 2aohB-3dm0A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		4 LEU A 234
GLY A  81
ALA A   9
ILE A 233
 None
 0.72A 2aohB-3e53A:
undetectable		 2aohB-3e53A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01678
(DAP_epimerase) 		4 LEU A 284
GLY A 146
ALA A 258
ILE A 286
 None
 0.79A 2aohB-3ekmA:
undetectable		 2aohB-3ekmA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5b AMINOGLYCOSIDE
N(6')ACETYLTRANSFERA
SE

(Legionella
pneumophila) 		PF13523
(Acetyltransf_8) 		4 ASP A  95
GLY A  42
ALA A  61
ILE A  77
 CHX  A 182 (-4.0A)
None
None
None
 0.84A 2aohB-3f5bA:
undetectable		 2aohB-3f5bA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 LEU A 262
GLY A 289
ALA A 109
ILE A 108
 None
 0.82A 2aohB-3f5fA:
undetectable		 2aohB-3f5fA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE

(Pseudomonas
putida) 		PF00180
(Iso_dh) 		4 LEU X 172
GLY X 249
ALA X 175
ILE X 171
 None
 0.68A 2aohB-3fmxX:
undetectable		 2aohB-3fmxX:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fna POSSIBLE ARABINOSE
5-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00571
(CBS) 		5 LEU A 329
ASP A 328
GLY A 322
ALA A 297
ILE A 216
 None
 1.40A 2aohB-3fnaA:
undetectable		 2aohB-3fnaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		4 LEU A 525
ASP A 529
ALA A 520
ILE A 521
 None
 0.78A 2aohB-3gzsA:
undetectable		 2aohB-3gzsA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		4 LEU A1299
GLY A1317
ALA A1307
ILE A1295
 None
 0.84A 2aohB-3jroA:
undetectable		 2aohB-3jroA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3q BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 LEU B 151
GLY B 104
ALA B 228
ILE B 111
 None
 0.84A 2aohB-3k3qB:
undetectable		 2aohB-3k3qB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke6 PROTEIN
RV1364C/MT1410

(Mycobacterium
tuberculosis) 		PF07228
(SpoIIE)
PF13581
(HATPase_c_2) 		4 LEU A 425
GLY A 470
ALA A 430
ILE A 428
 None
 0.80A 2aohB-3ke6A:
undetectable		 2aohB-3ke6A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khz PUTATIVE DIPEPTIDASE
SACOL1801

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20) 		4 LEU A 130
GLY A  80
ALA A 126
ILE A 127
 None
 0.86A 2aohB-3khzA:
undetectable		 2aohB-3khzA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krz NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Thermoanaerobacter
pseudethanolicus) 		PF00724
(Oxidored_FMN) 		4 LEU A 296
GLY A 284
ALA A 301
ILE A 295
 None
FMN  A 401 ( 3.7A)
None
None
 0.82A 2aohB-3krzA:
undetectable		 2aohB-3krzA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2j FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PARATHYROID
HORMONE/PARATHYROID
HORMONE-RELATED
PEPTIDE RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 LEU A -82
GLY A -55
ALA A-235
ILE A-236
 None
 0.79A 2aohB-3l2jA:
undetectable		 2aohB-3l2jA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF00117
(GATase) 		4 LEU A  49
GLY A  98
ALA A  80
ILE A  87
 None
 0.74A 2aohB-3l7nA:
undetectable		 2aohB-3l7nA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljy PUTATIVE ADHESIN

(Parabacteroides
distasonis) 		PF10988
(DUF2807) 		4 LEU A 151
GLY A 205
ALA A 168
ILE A 171
 None
 0.77A 2aohB-3ljyA:
undetectable		 2aohB-3ljyA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lom GERANYLTRANSTRANSFER
ASE

(Legionella
pneumophila) 		PF00348
(polyprenyl_synt) 		4 LEU A 135
GLY A 160
ALA A 131
ILE A 132
 None
 0.84A 2aohB-3lomA:
undetectable		 2aohB-3lomA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbf FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Encephalitozoon
cuniculi) 		PF00274
(Glycolytic) 		4 LEU A  72
GLY A  23
ALA A  27
ILE A  71
 None
None
None
2FP  A 345 ( 4.7A)
 0.84A 2aohB-3mbfA:
undetectable		 2aohB-3mbfA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 LEU A   5
GLY A  95
ALA A   9
ILE A   8
 None
 0.80A 2aohB-3mmtA:
undetectable		 2aohB-3mmtA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 546
GLY A 569
ALA A 549
ILE A 545
 None
 0.81A 2aohB-3mosA:
undetectable		 2aohB-3mosA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp6 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,LINKER,SAGA-
ASSOCIATED FACTOR 29

(Escherichia
coli;
Saccharomyces
cerevisiae;
unidentified) 		PF07039
(DUF1325)
PF13416
(SBP_bac_8) 		4 LEU A1000
GLY A1027
ALA A 847
ILE A 846
 None
 0.83A 2aohB-3mp6A:
undetectable		 2aohB-3mp6A:
10.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ASP A  25
GLY A  49
ILE A  84
 None
 0.33A 2aohB-3mwsA:
19.6		 2aohB-3mwsA:
78.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n93 MALTOSE BINDING
PROTEIN-CRFR2 ALPHA

(Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 LEU A-108
GLY A -81
ALA A-261
ILE A-262
 None
 0.82A 2aohB-3n93A:
undetectable		 2aohB-3n93A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 LEU A -86
GLY A -59
ALA A-239
ILE A-240
 None
 0.80A 2aohB-3n94A:
undetectable		 2aohB-3n94A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		4 LEU A 151
GLY A 137
ALA A 103
ILE A 153
 None
 0.78A 2aohB-3nvsA:
undetectable		 2aohB-3nvsA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF08205
(C2-set_2)
PF13416
(SBP_bac_8) 		4 LEU N 262
GLY N 289
ALA N 109
ILE N 108
 None
 0.82A 2aohB-3o3uN:
undetectable		 2aohB-3o3uN:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		4 ASP A 119
GLY A  91
ALA A 304
ILE A 308
 None
 0.83A 2aohB-3o75A:
undetectable		 2aohB-3o75A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Arachis
duranensis;
Escherichia
coli) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		4 LEU A 262
GLY A 289
ALA A 109
ILE A 108
 None
 0.86A 2aohB-3ob4A:
undetectable		 2aohB-3ob4A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		4 LEU A 545
GLY A 589
ALA A 541
ILE A 542
 None
 0.64A 2aohB-3opbA:
undetectable		 2aohB-3opbA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ops MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Paenibacillus
sp. Y412MC10) 		PF13378
(MR_MLE_C) 		4 LEU A  22
GLY A  57
ALA A  20
ILE A  47
 None
 0.86A 2aohB-3opsA:
undetectable		 2aohB-3opsA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 LEU A 510
GLY A 537
ALA A 109
ILE A 108
 None
 0.83A 2aohB-3osqA:
undetectable		 2aohB-3osqA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		4 LEU A 262
GLY A 289
ALA A 109
ILE A 108
 None
 0.81A 2aohB-3osrA:
undetectable		 2aohB-3osrA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus) 		PF13649
(Methyltransf_25) 		4 LEU A  64
GLY A 140
ALA A  68
ILE A  46
 None
 0.84A 2aohB-3ou6A:
undetectable		 2aohB-3ou6A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqs TRANSFERRIN-BINDING
PROTEIN

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 LEU A  87
ASP A 125
GLY A 122
ALA A  91
ILE A  90
 None
 1.19A 2aohB-3pqsA:
undetectable		 2aohB-3pqsA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py7 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PAXILLIN
LD1,PROTEIN E6
CHIMERA

(Deltapapillomavirus
4;
Escherichia
coli;
Homo sapiens) 		PF00518
(E6)
PF01547
(SBP_bac_1) 		4 LEU A 263
GLY A 290
ALA A 110
ILE A 109
 None
 0.85A 2aohB-3py7A:
undetectable		 2aohB-3py7A:
12.47