SIMILAR PATTERNS OF AMINO ACIDS FOR 2AOF_C_FRDC305_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1axn | ANNEXIN III (Homo sapiens) |
PF00191(Annexin) | 4 | ASP A 112GLY A 235ALA A 243ILE A 115 | None | 0.80A | 2aofA-1axnA:undetectable | 2aofA-1axnA:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b3q | PROTEIN (CHEMOTAXISPROTEIN CHEA) (Thermotogamaritima) |
PF01584(CheW)PF02518(HATPase_c)PF02895(H-kinase_dim) | 4 | GLY A 652PRO A 559ALA A 546ILE A 635 | None | 0.92A | 2aofA-1b3qA:undetectable | 2aofA-1b3qA:15.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cp2 | NITROGENASE IRONPROTEIN (Clostridiumpasteurianum) |
PF00142(Fer4_NifH) | 4 | GLY A 125PRO A 135ALA A 141ILE A 144 | None | 0.91A | 2aofA-1cp2A:undetectable | 2aofA-1cp2A:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d7b | CELLOBIOSEDEHYDROGENASE (Phanerochaetechrysosporium) |
PF16010(CDH-cyt) | 4 | ASP A 68GLY A 58PRO A 93ALA A 87 | NoneHEM A 401 (-3.5A)HEM A 401 (-4.5A)None | 0.82A | 2aofA-1d7bA:undetectable | 2aofA-1d7bA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d9z | EXCINUCLEASE UVRABCCOMPONENT UVRB ([Bacillus]caldotenax) |
PF00271(Helicase_C)PF04851(ResIII)PF12344(UvrB) | 4 | ASP A 207GLY A 217ALA A 242ILE A 243 | None | 0.90A | 2aofA-1d9zA:undetectable | 2aofA-1d9zA:9.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dcj | YHHP PROTEIN (Escherichiacoli) |
PF01206(TusA) | 4 | GLY A 54PRO A 22ALA A 14ILE A 41 | None | 0.89A | 2aofA-1dcjA:undetectable | 2aofA-1dcjA:20.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ASP A 25GLY A 49PRO A 81ILE A 84 | A79 A 800 (-2.7A)A79 A 800 ( 3.7A)A79 A 800 ( 3.9A)A79 A 800 (-3.6A) | 0.65A | 2aofA-1hvcA:14.0 | 2aofA-1hvcA:46.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ASP A 25GLY A 49PRO A 81ILE A 84 | A79 A 800 (-2.8A)A79 A 800 (-3.4A)A79 A 800 ( 3.4A)A79 A 800 (-3.8A) | 0.39A | 2aofA-1hvcA:14.0 | 2aofA-1hvcA:46.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ktn | 2-DEOXYRIBOSE-5-PHOSPHATE ALDOLASE (Escherichiacoli) |
PF01791(DeoC) | 4 | ASP A 102GLY A 199PRO A 202ALA A 203 | None | 0.95A | 2aofA-1ktnA:undetectable | 2aofA-1ktnA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lf9 | GLUCOAMYLASE (Thermoanaerobacteriumthermosaccharolyticum) |
PF00723(Glyco_hydro_15)PF09137(Glucodextran_N) | 4 | ASP A 673GLY A 607ALA A 657ILE A 661 | None | 0.91A | 2aofA-1lf9A:undetectable | 2aofA-1lf9A:10.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nmo | HYPOTHETICAL PROTEINYBGI (Escherichiacoli) |
PF01784(NIF3) | 4 | GLY A 139PRO A 154ALA A 213ILE A 191 | None | 0.96A | 2aofA-1nmoA:undetectable | 2aofA-1nmoA:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ope | SUCCINYL-COA:3-KETOACID-COENZYME ATRANSFERASE (Sus scrofa) |
PF01144(CoA_trans) | 4 | GLY A 90PRO A 132ALA A 144ILE A 143 | None | 0.92A | 2aofA-1opeA:undetectable | 2aofA-1opeA:15.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pcv | OSMOTIN (Nicotianatabacum) |
PF00314(Thaumatin) | 4 | GLY A 118PRO A 112ALA A 111ILE A 123 | None | 0.81A | 2aofA-1pcvA:undetectable | 2aofA-1pcvA:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qvz | YDR533C PROTEIN (Saccharomycescerevisiae) |
PF01965(DJ-1_PfpI) | 4 | ASP A 206GLY A 169PRO A 221ALA A 222 | NoneNoneCSO A 138 ( 4.9A)None | 0.93A | 2aofA-1qvzA:undetectable | 2aofA-1qvzA:20.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 4 | ASP A 25GLY A 48PRO A 81ILE A 84 | None | 0.93A | 2aofA-1sivA:18.6 | 2aofA-1sivA:51.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 4 | ASP A 25GLY A 49PRO A 81ILE A 84 | None | 0.36A | 2aofA-1sivA:18.6 | 2aofA-1sivA:51.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1txc | PATHOGENESIS-RELATEDCLASS 10 PROTEINSPE-16 (Pachyrhizuserosus) |
PF00407(Bet_v_1) | 4 | GLY A 139PRO A 36ALA A 57ILE A 55 | 2AN A 716 (-3.7A)2AN A 715 (-4.4A)2AN A 716 (-3.4A)2AN A 716 (-4.2A) | 0.96A | 2aofA-1txcA:undetectable | 2aofA-1txcA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uyv | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF01039(Carboxyl_trans) | 4 | ASP A1601GLY A1626ALA A1712ILE A1711 | None | 0.89A | 2aofA-1uyvA:undetectable | 2aofA-1uyvA:8.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w6j | LANOSTEROL SYNTHASE (Homo sapiens) |
PF13243(SQHop_cyclase_C)PF13249(SQHop_cyclase_N) | 4 | ASP A 138GLY A 142ALA A 176ILE A 179 | None | 0.92A | 2aofA-1w6jA:undetectable | 2aofA-1w6jA:7.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wiw | GLUCOSE-6-PHOSPHATEISOMERASE LIKEPROTEIN (Thermusthermophilus) |
PF10432(bact-PGI_C) | 4 | GLY A 43PRO A 111ALA A 110ILE A 104 | None | 0.89A | 2aofA-1wiwA:undetectable | 2aofA-1wiwA:14.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wkb | LEUCYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1) | 4 | GLY A 84PRO A 122ALA A 91ILE A 90 | SO4 A 901 (-3.3A)NoneNoneNone | 0.91A | 2aofA-1wkbA:undetectable | 2aofA-1wkbA:10.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bfr | HYPOTHETICAL PROTEINAF1521 (Archaeoglobusfulgidus) |
PF01661(Macro) | 4 | GLY A 19PRO A 25ALA A 26ILE A 29 | None | 0.94A | 2aofA-2bfrA:undetectable | 2aofA-2bfrA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bty | ACETYLGLUTAMATEKINASE (Thermotogamaritima) |
PF00696(AA_kinase) | 4 | GLY A 29PRO A 64ALA A 65ILE A 102 | NLG A1284 (-3.0A)NoneNoneNone | 0.93A | 2aofA-2btyA:undetectable | 2aofA-2btyA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ctz | O-ACETYL-L-HOMOSERINE SULFHYDRYLASE (Thermusthermophilus) |
PF01053(Cys_Met_Meta_PP) | 4 | ASP A 221GLY A 252ALA A 260ILE A 257 | None | 0.93A | 2aofA-2ctzA:undetectable | 2aofA-2ctzA:12.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f2a | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A (Staphylococcusaureus) |
PF01425(Amidase) | 4 | ASP A 37GLY A 77ALA A 32ILE A 33 | None | 0.93A | 2aofA-2f2aA:undetectable | 2aofA-2f2aA:12.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 4 | ASP A 25GLY A 55PRO A 86ILE A 89 | LP1 A 201 (-2.3A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 (-4.2A) | 0.35A | 2aofA-2fmbA:15.0 | 2aofA-2fmbA:33.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g0t | CONSERVEDHYPOTHETICAL PROTEIN (Thermotogamaritima) |
PF07755(DUF1611)PF17396(DUF1611_N) | 4 | GLY A 31PRO A 41ALA A 13ILE A 82 | None | 0.88A | 2aofA-2g0tA:undetectable | 2aofA-2g0tA:14.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i0o | SER/THR PHOSPHATASE (Anophelesgambiae) |
PF00481(PP2C) | 4 | ASP A 479GLY A 470PRO A 445ILE A 495 | None | 0.88A | 2aofA-2i0oA:undetectable | 2aofA-2i0oA:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iae | SERINE/THREONINE-PROTEIN PHOSPHATASE 2A56 KDA REGULATORYSUBUNIT GAMMAISOFORM (Homo sapiens) |
PF01603(B56) | 4 | GLY B 191PRO B 152ALA B 155ILE B 159 | None | 0.90A | 2aofA-2iaeB:undetectable | 2aofA-2iaeB:12.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jak | SERINE/THREONINE-PROTEIN PHOSPHATASE 2A56 KDA REGULATORYSUBUNIT GAMMAISOFORM (Homo sapiens) |
PF01603(B56) | 4 | GLY A 191PRO A 152ALA A 155ILE A 159 | None | 0.95A | 2aofA-2jakA:undetectable | 2aofA-2jakA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o3j | UDP-GLUCOSE6-DEHYDROGENASE (Caenorhabditiselegans) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 4 | ASP A 386GLY A 281ALA A 357ILE A 358 | None | 0.93A | 2aofA-2o3jA:undetectable | 2aofA-2o3jA:14.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25GLY A 49PRO A 81ALA A 82ILE A 84 | AB1 A 501 (-2.4A)AB1 A 501 (-3.5A)AB1 A 501 (-4.2A)AB1 A 501 (-3.6A)AB1 A 501 ( 4.2A) | 0.37A | 2aofA-2rkfA:20.9 | 2aofA-2rkfA:83.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | GLY A 48PRO A 81ALA A 82ILE A 84 | AB1 A 501 (-4.2A)AB1 A 501 (-4.2A)AB1 A 501 (-3.6A)AB1 A 501 ( 4.2A) | 0.81A | 2aofA-2rkfA:20.9 | 2aofA-2rkfA:83.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v8n | LACTOSE PERMEASE (Escherichiacoli) |
PF01306(LacY_symp) | 4 | GLY A 115PRO A 123ALA A 124ILE A 80 | None | 0.95A | 2aofA-2v8nA:undetectable | 2aofA-2v8nA:12.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vun | ENAMIDASE (Eubacteriumbarkeri) |
PF01979(Amidohydro_1) | 4 | GLY A 38PRO A 327ALA A 326ILE A 325 | None | 0.86A | 2aofA-2vunA:undetectable | 2aofA-2vunA:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y5j | DIHYDROPTEROATESYNTHASE (Burkholderiacenocepacia) |
PF00809(Pterin_bind) | 4 | GLY A 140PRO A 225ALA A 265ILE A 266 | None | 0.85A | 2aofA-2y5jA:undetectable | 2aofA-2y5jA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bf0 | PROTEASE 4 (Escherichiacoli) |
PF01343(Peptidase_S49) | 4 | GLY A 411PRO A 417ALA A 418ILE A 421 | None | 0.67A | 2aofA-3bf0A:undetectable | 2aofA-3bf0A:11.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bio | OXIDOREDUCTASE,GFO/IDH/MOCA FAMILY (Porphyromonasgingivalis) |
PF01408(GFO_IDH_MocA)PF16654(DAPDH_C) | 4 | GLY A 151PRO A 256ALA A 257ILE A 253 | NoneACT A3001 ( 4.1A)NoneNone | 0.90A | 2aofA-3bioA:undetectable | 2aofA-3bioA:15.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f5b | AMINOGLYCOSIDEN(6')ACETYLTRANSFERASE (Legionellapneumophila) |
PF13523(Acetyltransf_8) | 4 | ASP A 95GLY A 42ALA A 61ILE A 77 | CHX A 182 (-4.0A)NoneNoneNone | 0.84A | 2aofA-3f5bA:undetectable | 2aofA-3f5bA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ff6 | ACETYL-COACARBOXYLASE 2 (Homo sapiens) |
PF01039(Carboxyl_trans) | 4 | ASP A1807GLY A1832ALA A1915ILE A1914 | None | 0.88A | 2aofA-3ff6A:undetectable | 2aofA-3ff6A:8.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g25 | GLYCEROL KINASE (Staphylococcusaureus) |
PF00370(FGGY_N)PF02782(FGGY_C) | 4 | ASP A 294GLY A 447ALA A 218ILE A 293 | None | 0.92A | 2aofA-3g25A:undetectable | 2aofA-3g25A:15.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gka | N-ETHYLMALEIMIDEREDUCTASE (Burkholderiapseudomallei) |
PF00724(Oxidored_FMN) | 4 | GLY A 231PRO A 31ALA A 30ILE A 28 | NoneFMN A 362 (-3.6A)FMN A 362 (-3.4A)None | 0.78A | 2aofA-3gkaA:undetectable | 2aofA-3gkaA:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdc | THIOREDOXIN FAMILYPROTEIN (Geobactermetallireducens) |
PF00578(AhpC-TSA) | 4 | GLY A 130PRO A 40ALA A 39ILE A 146 | None | 0.95A | 2aofA-3hdcA:undetectable | 2aofA-3hdcA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j09 | COPPER-EXPORTINGP-TYPE ATPASE A (Archaeoglobusfulgidus) |
PF00122(E1-E2_ATPase)PF00403(HMA)PF00702(Hydrolase) | 4 | ASP A 424GLY A 277PRO A 624ALA A 625 | None | 0.60A | 2aofA-3j09A:undetectable | 2aofA-3j09A:8.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jzz | TYPE IV PILINSTRUCTURAL SUBUNIT (Pseudomonasaeruginosa) |
PF00114(Pilin) | 4 | GLY A 36PRO A 42ALA A 43ILE A 92 | None | 0.86A | 2aofA-3jzzA:undetectable | 2aofA-3jzzA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kl0 | GLUCURONOXYLANASEXYNC (Bacillussubtilis) |
PF17189(Glyco_hydro_30C) | 4 | ASP A 224GLY A 18ALA A 134ILE A 198 | None | 0.91A | 2aofA-3kl0A:undetectable | 2aofA-3kl0A:12.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ASP A 25GLY A 49PRO A 81ILE A 84 | None | 0.37A | 2aofA-3mwsA:20.3 | 2aofA-3mwsA:78.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o75 | FRUCTOSE TRANSPORTSYSTEM REPRESSORFRUR (Pseudomonasputida) |
PF00532(Peripla_BP_1) | 4 | ASP A 119GLY A 91ALA A 304ILE A 308 | None | 0.81A | 2aofA-3o75A:undetectable | 2aofA-3o75A:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rv6 | ISOCHORISMATESYNTHASE/ISOCHORISMATE-PYRUVATE LYASEMBTI (Mycobacteriumtuberculosis) |
PF00425(Chorismate_bind) | 4 | ASP A 378GLY A 421ALA A 373ILE A 374 | NoneVAE A 451 ( 4.2A)NoneNone | 0.91A | 2aofA-3rv6A:undetectable | 2aofA-3rv6A:12.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sy8 | ROCR (Pseudomonasaeruginosa) |
PF00072(Response_reg)PF00563(EAL) | 4 | GLY A 391PRO A 162ALA A 174ILE A 228 | None | 0.80A | 2aofA-3sy8A:undetectable | 2aofA-3sy8A:12.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ASP A 25GLY A 49PRO A 81ALA A 82 | 017 A 201 (-2.6A)017 A 201 (-4.0A)NoneSO4 A 101 (-3.5A) | 0.67A | 2aofA-3t3cA:18.6 | 2aofA-3t3cA:75.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ASP A 25GLY A 49PRO A 81ILE A 84 | 017 A 201 (-2.6A)017 A 201 (-3.0A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.34A | 2aofA-3ttpA:19.8 | 2aofA-3ttpA:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wnp | CYCLOISOMALTOOLIGOSACCHARIDEGLUCANOTRANSFERASE (Bacilluscirculans) |
PF13199(Glyco_hydro_66)PF16990(CBM_35) | 4 | GLY A 420PRO A 465ALA A 464ILE A 462 | None | 0.91A | 2aofA-3wnpA:undetectable | 2aofA-3wnpA:9.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zre | THIOL PEROXIDASE (Yersiniapseudotuberculosis) |
PF08534(Redoxin) | 4 | ASP A 57GLY A 96ALA A 62ILE A 56 | None | 0.95A | 2aofA-3zreA:undetectable | 2aofA-3zreA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zz1 | BETA-D-GLUCOSIDEGLUCOHYDROLASE (Trichodermareesei) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | GLY A 574PRO A 569ALA A 533ILE A 532 | None | 0.92A | 2aofA-3zz1A:undetectable | 2aofA-3zz1A:9.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a01 | PROTONPYROPHOSPHATASE (Vigna radiata) |
PF03030(H_PPase) | 4 | ASP A 8GLY A 316PRO A 385ALA A 4 | None | 0.93A | 2aofA-4a01A:undetectable | 2aofA-4a01A:10.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dg8 | PA1221 (Pseudomonasaeruginosa) |
PF00501(AMP-binding) | 4 | ASP A 400GLY A 306ALA A 363ILE A 361 | AMP A 701 (-2.6A)AMP A 701 (-4.7A)NoneNone | 0.91A | 2aofA-4dg8A:undetectable | 2aofA-4dg8A:11.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f2a | CHOLESTERYL ESTERTRANSFER PROTEIN (Homo sapiens) |
PF01273(LBP_BPI_CETP)PF02886(LBP_BPI_CETP_C) | 4 | GLY A 256PRO A 18ALA A 19ILE A 15 | NoneNoneNone2OB A 605 (-3.8A) | 0.87A | 2aofA-4f2aA:undetectable | 2aofA-4f2aA:12.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gvl | TRKA DOMAIN PROTEIN (Geobactersulfurreducens) |
PF02080(TrkA_C)PF02254(TrkA_N) | 4 | GLY A 502PRO A 524ALA A 523ILE A 521 | None | 0.92A | 2aofA-4gvlA:undetectable | 2aofA-4gvlA:11.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h7u | PYRANOSEDEHYDROGENASE (Leucoagaricusmeleagris) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 4 | ASP A 198GLY A 162ALA A 171ILE A 156 | None | 0.93A | 2aofA-4h7uA:undetectable | 2aofA-4h7uA:12.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hn9 | IRON COMPLEXTRANSPORT SYSTEMSUBSTRATE-BINDINGPROTEIN ([Eubacterium]eligens) |
PF01497(Peripla_BP_2) | 4 | ASP A 93GLY A 350PRO A 113ALA A 114 | None | 0.77A | 2aofA-4hn9A:undetectable | 2aofA-4hn9A:14.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igl | YENB (Yersiniaentomophaga) |
PF03534(SpvB)PF12255(TcdB_toxin_midC)PF12256(TcdB_toxin_midN) | 4 | GLY A 158PRO A 188ALA A 183ILE A 191 | None | 0.94A | 2aofA-4iglA:undetectable | 2aofA-4iglA:6.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iws | PA0254 (Pseudomonasaeruginosa) |
PF01977(UbiD) | 4 | GLY A 152PRO A 67ALA A 68ILE A 321 | None | 0.84A | 2aofA-4iwsA:undetectable | 2aofA-4iwsA:11.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jgb | PUTATIVE EXPORTEDPROTEIN (Burkholderiapseudomallei) |
PF13460(NAD_binding_10) | 4 | GLY A 11PRO A 158ALA A 157ILE A 156 | SO4 A 302 (-3.3A)NoneNoneNone | 0.79A | 2aofA-4jgbA:undetectable | 2aofA-4jgbA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jgb | PUTATIVE EXPORTEDPROTEIN (Burkholderiapseudomallei) |
PF13460(NAD_binding_10) | 4 | GLY A 14PRO A 158ALA A 157ILE A 156 | None | 0.77A | 2aofA-4jgbA:undetectable | 2aofA-4jgbA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n0q | LEU/ILE/VAL-BINDINGPROTEIN HOMOLOG 3 (Brucellamelitensis) |
PF13458(Peripla_BP_6) | 4 | GLY A 102PRO A 32ALA A 31ILE A 30 | None | 0.95A | 2aofA-4n0qA:undetectable | 2aofA-4n0qA:14.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n2p | PROTEIN ARCHEASE (Pyrococcushorikoshii) |
PF01951(Archease) | 4 | ASP A 83GLY A 20ALA A 31ILE A 32 | None | 0.96A | 2aofA-4n2pA:undetectable | 2aofA-4n2pA:21.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ASP A 25GLY A 49PRO A 81ILE A 84 | RIT A 500 (-2.4A)RIT A 500 (-3.4A)RIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.35A | 2aofA-4njvA:21.1 | 2aofA-4njvA:84.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o48 | UNCHARACTERIZEDPROTEIN (Cavia porcellus) |
PF01112(Asparaginase_2) | 4 | ASP A 199GLY A 10ALA A 231ILE A 225 | ASP A 402 (-3.0A)NoneNoneNone | 0.96A | 2aofA-4o48A:undetectable | 2aofA-4o48A:14.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovk | PERIPLASMIC BINDINGPROTEIN (Veillonellaparvula) |
PF01497(Peripla_BP_2) | 4 | GLY A 318PRO A 297ALA A 296ILE A 260 | None | 0.82A | 2aofA-4ovkA:undetectable | 2aofA-4ovkA:15.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p56 | PUTATIVEEXTRACELLULARSOLUTE-BINDINGPROTEIN (Bordetellabronchiseptica) |
PF03480(DctP) | 4 | ASP A 340GLY A 147ALA A 120ILE A 336 | None | 0.85A | 2aofA-4p56A:undetectable | 2aofA-4p56A:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q8h | PAB-DEPENDENTPOLY(A)-SPECIFICRIBONUCLEASE SUBUNITPAN2 (Saccharomycescerevisiae) |
PF00929(RNase_T)PF13423(UCH_1) | 4 | ASP A 959GLY A 977ALA A1072ILE A1069 | None | 0.94A | 2aofA-4q8hA:undetectable | 2aofA-4q8hA:9.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qnw | CHANOCLAVINE-IALDEHYDE REDUCTASE (Aspergillusfumigatus) |
PF00724(Oxidored_FMN) | 4 | GLY A 223PRO A 29ALA A 28ILE A 26 | NoneFMN A 401 (-3.7A)FMN A 401 (-3.4A)None | 0.68A | 2aofA-4qnwA:undetectable | 2aofA-4qnwA:14.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rs3 | ABC TRANSPORTER,CARBOHYDRATE UPTAKETRANSPORTER-2 (CUT2)FAMILY, PERIPLASMICSUGAR-BINDINGPROTEIN (Mycolicibacteriumsmegmatis) |
PF13407(Peripla_BP_4) | 4 | ASP A 249GLY A 163ALA A 140ILE A 248 | XYL A 401 (-2.7A)NoneNoneNone | 0.85A | 2aofA-4rs3A:undetectable | 2aofA-4rs3A:15.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rsm | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Mycolicibacteriumsmegmatis) |
PF13407(Peripla_BP_4) | 4 | ASP A 249GLY A 163ALA A 140ILE A 248 | 3VB A 401 (-2.7A)NoneNoneNone | 0.86A | 2aofA-4rsmA:undetectable | 2aofA-4rsmA:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tr4 | TYPE IIIIODOTHYRONINEDEIODINASE (Mus musculus) |
PF00837(T4_deiodinase) | 4 | GLY A 255PRO A 136ALA A 135ILE A 269 | None | 0.91A | 2aofA-4tr4A:undetectable | 2aofA-4tr4A:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wwv | AMINOPEPTIDASE FROMFAMILY M42 (Desulfurococcusamylolyticus) |
PF05343(Peptidase_M42) | 4 | ASP A 231GLY A 61ALA A 354ILE A 359 | None | 0.77A | 2aofA-4wwvA:undetectable | 2aofA-4wwvA:14.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ax0 | RHODOPSIN I (Acetabulariaacetabulum) |
PF01036(Bac_rhodopsin) | 4 | ASP A 204GLY A 67ALA A 15ILE A 207 | None | 0.92A | 2aofA-5ax0A:undetectable | 2aofA-5ax0A:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwd | BENZYLSUCCINATESYNTHASE ALPHA CHAIN (Thaueraaromatica) |
PF01228(Gly_radical)PF02901(PFL-like) | 4 | ASP A 733GLY A 706PRO A 517ALA A 518 | None | 0.71A | 2aofA-5bwdA:undetectable | 2aofA-5bwdA:8.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bz3 | NA(+)/H(+)ANTIPORTER (Thermusthermophilus) |
PF00999(Na_H_Exchanger) | 4 | GLY A 217PRO A 260ALA A 263ILE A 264 | None | 0.89A | 2aofA-5bz3A:undetectable | 2aofA-5bz3A:15.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c04 | PUTATIVEPEROXIREDOXIN MT2298 (Mycobacteriumtuberculosis) |
PF00578(AhpC-TSA) | 4 | GLY A 105PRO A 9ALA A 8ILE A 127 | None | 0.92A | 2aofA-5c04A:undetectable | 2aofA-5c04A:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c5y | DEOXYRIBOSE-PHOSPHATE ALDOLASE (Colwelliapsychrerythraea) |
PF01791(DeoC) | 4 | ASP A 102GLY A 196PRO A 199ALA A 200 | UNL A 301 ( 4.9A)NoneNoneUNL A 301 ( 4.2A) | 0.95A | 2aofA-5c5yA:undetectable | 2aofA-5c5yA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eco | JASMONIC ACID-AMIDOSYNTHETASE JAR1 (Arabidopsisthaliana) |
PF03321(GH3) | 4 | GLY A 91PRO A 95ALA A 96ILE A 97 | None | 0.95A | 2aofA-5ecoA:undetectable | 2aofA-5ecoA:10.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ept | PEROXIREDOXIN TSA2 (Saccharomycescerevisiae) |
no annotation | 4 | GLY H 113PRO H 10ALA H 9ILE H 135 | None | 0.88A | 2aofA-5eptH:undetectable | 2aofA-5eptH:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fjj | BETA-GLUCOSIDASE (Aspergillusoryzae) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | ASP A 730GLY A 320ALA A 738ILE A 734 | NoneNAG A1301 (-3.6A)NoneNone | 0.83A | 2aofA-5fjjA:undetectable | 2aofA-5fjjA:7.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i51 | TRANSKETOLASE (Scheffersomycesstipitis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | ASP A 183GLY A 249PRO A 36ALA A 37 | None | 0.84A | 2aofA-5i51A:undetectable | 2aofA-5i51A:9.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6g | ACETYL-COACARBOXYLASE-LIKEPROTEIN,ACETYL-COACARBOXYLASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01039(Carboxyl_trans)PF08326(ACC_central) | 4 | ASP A1646GLY A1671ALA A1752ILE A1751 | None | 0.88A | 2aofA-5i6gA:undetectable | 2aofA-5i6gA:6.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6h | ACETYL-COACARBOXYLASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01039(Carboxyl_trans)PF08326(ACC_central) | 4 | ASP A1646GLY A1671ALA A1752ILE A1751 | None | 0.85A | 2aofA-5i6hA:undetectable | 2aofA-5i6hA:6.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6i | ACETYL-COACARBOXYLASE-LIKEPROTEIN,ACETYL-COACARBOXYLASE-LIKEPROTEIN,ACETYL-COACARBOXYLASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01039(Carboxyl_trans)PF08326(ACC_central) | 4 | ASP A1646GLY A1671ALA A1752ILE A1751 | None | 0.84A | 2aofA-5i6iA:undetectable | 2aofA-5i6iA:4.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jja | SERINE/THREONINE-PROTEIN PHOSPHATASE 2A56 KDA REGULATORYSUBUNIT GAMMAISOFORM (Homo sapiens) |
PF01603(B56) | 4 | GLY A 191PRO A 152ALA A 155ILE A 159 | GLY A 191 ( 0.0A)PRO A 152 ( 1.1A)ALA A 155 ( 0.0A)ILE A 159 ( 0.7A) | 0.88A | 2aofA-5jjaA:undetectable | 2aofA-5jjaA:16.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ASP A 25GLY A 49PRO A 81ILE A 84 | None | 0.34A | 2aofA-5t2zA:20.2 | 2aofA-5t2zA:80.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5i | TUNGSTEN-CONTAININGFORMYLMETHANOFURANDEHYDROGENASE 2SUBUNIT C (Methanothermobacterwolfeii) |
PF01493(GXGXG) | 4 | GLY C 221PRO C 270ALA C 269ILE C 268 | None | 0.90A | 2aofA-5t5iC:undetectable | 2aofA-5t5iC:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t9t | PROTOCADHERIN GAMMAB2-ALPHA C (Mus musculus) |
PF00028(Cadherin)PF08266(Cadherin_2) | 4 | ASP A 448GLY A 508ALA A 504ILE A 457 | CA A 612 (-2.5A)NoneNoneNone | 0.90A | 2aofA-5t9tA:undetectable | 2aofA-5t9tA:11.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tcb | PELA (Pseudomonasaeruginosa) |
PF03537(Glyco_hydro_114) | 4 | GLY A 295PRO A 284ALA A 258ILE A 259 | None | 0.83A | 2aofA-5tcbA:undetectable | 2aofA-5tcbA:13.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2g | PENICILLIN-BINDINGPROTEIN 1A (Haemophilusinfluenzae) |
PF00905(Transpeptidase)PF00912(Transgly)PF17092(PCB_OB) | 4 | ASP A 756GLY A 432PRO A 410ALA A 411 | CL A 909 ( 4.5A)NoneNoneNone | 0.95A | 2aofA-5u2gA:undetectable | 2aofA-5u2gA:8.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u99 | ATPPHOSPHORIBOSYLTRANSFERASE (Mycobacteriumtuberculosis) |
PF01634(HisG)PF08029(HisG_C) | 4 | GLY A 147PRO A 97ALA A 96ILE A 152 | None | 0.90A | 2aofA-5u99A:undetectable | 2aofA-5u99A:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x6o | DNA DAMAGECHECKPOINT PROTEINLCD1 (Saccharomycescerevisiae) |
no annotation | 4 | ASP G 497GLY G 526ALA G 534ILE G 537 | None | 0.89A | 2aofA-5x6oG:undetectable | 2aofA-5x6oG:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6acd | - (-) |
no annotation | 4 | GLY A 418PRO A 399ALA A 398ILE A 397 | None | 0.91A | 2aofA-6acdA:undetectable | 2aofA-6acdA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bz0 | DIHYDROLIPOYLDEHYDROGENASE (Acinetobacterbaumannii) |
no annotation | 4 | GLY A 385PRO A 421ALA A 422ILE A 426 | None | 0.92A | 2aofA-6bz0A:undetectable | 2aofA-6bz0A:23.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 4 | ASP A 25GLY A 49PRO A 81ILE A 84 | NIU A 100 (-2.8A)NIU A 100 ( 3.8A)NoneNone | 0.61A | 2aofA-6upjA:18.2 | 2aofA-6upjA:49.49 |